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chr7:75,059,331-78,122,616

Best TWAS P=1.59e-24 · Best GWAS P=3.24e-60 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RSBN1L	0.09	0.09	enet	9	0.09	2.0e-11	6.59	6.3	2.4e-10	-0.11	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	TMEM60	0.08	0.05	lasso	4	0.05	7.3e-05	6.57	7.2	7.5e-13	-0.12	0.02	0.97	FALSE
3	GTEx	Adipose Subcutaneous	TRIM73	0.20	0.12	enet	26	0.12	2.0e-10	-0.07	-5.9	4.7e-09	-0.21	1.00	0.00	TRUE
4	GTEx	Adipose Subcutaneous	RSBN1L-AS1	0.23	0.13	enet	33	0.22	9.2e-18	-3.92	5.7	1.0e-08	-0.06	0.06	0.94	FALSE
5	GTEx	Adipose Visceral Omentum	TMEM60	0.20	0.13	lasso	8	0.11	2.3e-06	6.28	7.1	1.6e-12	-0.11	0.02	0.98	FALSE
6	GTEx	Adipose Visceral Omentum	RSBN1L-AS1	0.18	0.12	lasso	2	0.14	1.0e-07	-4.08	5.3	1.4e-07	-0.03	0.63	0.34	FALSE
7	GTEx	Adrenal Gland	TMEM120A	0.11	-0.01	lasso	6	0.00	5.0e-01	-5.69	6.5	9.5e-11	0.06	0.13	0.07	FALSE
8	GTEx	Artery Aorta	POR	0.09	0.09	lasso	4	0.05	1.3e-03	-5.14	-5.2	1.8e-07	-0.06	0.58	0.04	FALSE
9	GTEx	Artery Aorta	RSBN1L-AS1	0.26	0.18	lasso	10	0.25	5.0e-14	-3.98	5.2	1.5e-07	-0.03	0.83	0.17	FALSE
10	GTEx	Artery Tibial	ZP3	0.72	0.63	enet	32	0.71	4.3e-77	-3.52	-5.8	5.7e-09	0.03	1.00	0.00	TRUE
11	GTEx	Artery Tibial	RSBN1L-AS1	0.28	0.13	enet	13	0.28	5.5e-22	-4.08	6.2	6.0e-10	-0.05	0.03	0.97	FALSE
12	GTEx	Brain Caudate basal ganglia	RSBN1L-AS1	0.28	0.06	lasso	4	0.08	2.7e-03	-3.98	5.2	2.3e-07	-0.02	0.09	0.54	FALSE
13	GTEx	Brain Cerebellum	POR	0.15	0.06	lasso	4	0.04	3.3e-02	-9.40	-9.1	1.4e-19	-0.05	0.11	0.05	TRUE
14	GTEx	Brain Cerebellum	RSBN1L	0.14	0.12	lasso	2	0.13	1.3e-04	-4.95	-5.4	6.7e-08	0.06	0.06	0.89	FALSE
15	GTEx	Brain Cortex	RSBN1L-AS1	0.34	0.15	enet	23	0.23	5.8e-07	-4.08	6.2	5.2e-10	-0.06	0.05	0.94	FALSE
16	GTEx	Breast Mammary Tissue	RSBN1L-AS1	0.32	0.22	lasso	5	0.24	1.9e-12	-3.98	5.8	6.4e-09	-0.04	0.40	0.60	FALSE
17	GTEx	Breast Mammary Tissue (Female)	RSBN1L-AS1	0.27	0.25	lasso	4	0.20	1.2e-06	-3.98	5.2	2.3e-07	-0.02	0.14	0.72	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	RSBN1L-AS1	0.23	0.11	enet	6	0.18	1.2e-06	-3.98	5.2	2.5e-07	-0.04	0.08	0.78	FALSE
19	GTEx	Cells Transformed fibroblasts	TMEM60	0.25	0.20	lasso	4	0.20	1.5e-14	6.11	6.2	4.1e-10	-0.11	0.09	0.91	FALSE
20	GTEx	Cells Transformed fibroblasts	ZP3	0.53	0.46	enet	26	0.49	8.2e-42	-3.52	-5.7	1.6e-08	0.02	1.00	0.00	FALSE
21	GTEx	Cells Transformed fibroblasts	RSBN1L-AS1	0.23	0.19	lasso	6	0.21	5.7e-16	7.09	7.0	2.1e-12	-0.07	0.00	1.00	FALSE
22	GTEx	Colon Sigmoid	RHBDD2	0.23	0.12	lasso	5	0.10	2.2e-04	6.98	5.8	5.9e-09	0.19	0.07	0.06	TRUE
23	GTEx	Colon Sigmoid	RSBN1L	0.17	0.09	lasso	2	0.05	5.5e-03	6.49	6.9	5.8e-12	-0.11	0.03	0.87	FALSE
24	GTEx	Colon Sigmoid	RSBN1L-AS1	0.46	0.48	lasso	6	0.50	5.0e-20	7.09	7.2	5.1e-13	-0.10	0.01	0.99	FALSE
25	GTEx	Colon Transverse	RSBN1L-AS1	0.32	0.24	lasso	9	0.22	5.7e-11	7.09	7.0	2.8e-12	-0.09	0.01	0.99	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	POR	0.26	0.17	lasso	4	0.13	1.9e-05	-4.94	-5.9	4.1e-09	-0.09	0.78	0.01	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	RSBN1L-AS1	0.38	0.41	lasso	12	0.44	1.2e-17	6.28	6.6	5.0e-11	-0.11	0.01	0.99	FALSE
28	GTEx	Esophagus Mucosa	POR	0.11	0.05	enet	17	0.07	1.7e-05	-9.40	-6.3	3.0e-10	0.03	0.38	0.07	FALSE
29	GTEx	Esophagus Mucosa	TMEM60	0.06	0.04	lasso	2	0.04	1.0e-03	6.11	6.2	4.3e-10	-0.10	0.02	0.98	FALSE
30	GTEx	Esophagus Mucosa	TMEM120A	0.07	0.01	enet	10	0.02	2.6e-02	-9.40	-9.2	4.0e-20	-0.09	0.26	0.04	FALSE
31	GTEx	Esophagus Mucosa	RSBN1L-AS1	0.26	0.22	enet	26	0.22	2.0e-14	-3.98	5.2	1.9e-07	-0.04	1.00	0.00	FALSE
32	GTEx	Esophagus Muscularis	HIP1	0.07	0.03	lasso	3	0.00	6.6e-01	-5.66	-7.0	3.2e-12	-0.18	0.22	0.04	TRUE
33	GTEx	Esophagus Muscularis	RSBN1L	0.07	0.03	lasso	3	0.01	4.3e-02	6.13	6.2	7.0e-10	-0.10	0.05	0.89	FALSE
34	GTEx	Esophagus Muscularis	ZP3	0.72	0.47	enet	48	0.52	8.4e-37	-3.52	-5.6	1.9e-08	0.01	1.00	0.00	FALSE
35	GTEx	Esophagus Muscularis	RSBN1L-AS1	0.35	0.51	lasso	5	0.52	3.8e-36	7.09	7.2	4.2e-13	-0.10	0.00	1.00	FALSE
36	GTEx	Heart Left Ventricle	RSBN1L-AS1	0.24	0.15	lasso	7	0.14	6.3e-08	-3.98	5.4	5.6e-08	-0.04	0.48	0.51	FALSE
37	GTEx	Muscle Skeletal	TMEM60	0.11	0.12	lasso	4	0.12	4.6e-12	6.11	-6.0	1.8e-09	0.10	0.02	0.98	FALSE
38	GTEx	Muscle Skeletal	RSBN1L-AS1	0.22	0.18	lasso	4	0.22	7.3e-21	-4.95	5.4	6.7e-08	-0.03	0.99	0.01	FALSE
39	GTEx	Nerve Tibial	RHBDD2	0.14	0.00	lasso	3	0.00	6.0e-01	-6.51	-8.5	2.0e-17	-0.20	0.05	0.06	FALSE
40	GTEx	Nerve Tibial	POR	0.11	0.07	enet	28	0.06	4.4e-05	-4.93	-6.5	6.1e-11	-0.21	0.64	0.05	FALSE
41	GTEx	Nerve Tibial	TMEM60	0.14	0.14	lasso	8	0.12	1.1e-08	6.11	6.4	1.7e-10	-0.11	0.02	0.98	FALSE
42	GTEx	Nerve Tibial	MDH2	0.05	0.00	lasso	4	0.00	5.8e-01	-4.83	5.6	2.1e-08	0.09	0.16	0.04	FALSE
43	GTEx	Nerve Tibial	RSBN1L-AS1	0.35	0.20	lasso	12	0.27	1.8e-19	-3.92	5.9	3.5e-09	-0.05	0.76	0.24	FALSE
44	GTEx	Ovary	TMEM60	0.23	0.19	enet	7	0.13	5.2e-04	5.60	6.2	4.9e-10	-0.07	0.05	0.77	FALSE
45	GTEx	Ovary	RSBN1L-AS1	0.21	0.22	enet	20	0.16	8.1e-05	7.09	7.5	4.5e-14	-0.11	0.02	0.94	TRUE
46	GTEx	Pituitary	TMEM60	0.19	0.06	lasso	6	0.04	2.8e-02	-4.89	5.5	3.9e-08	-0.08	0.04	0.90	FALSE
47	GTEx	Prostate	AC004980.7	0.67	0.03	lasso	10	0.02	1.0e-01	-3.52	-5.2	1.8e-07	-0.02	0.03	0.28	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	TMEM60	0.14	0.08	lasso	4	0.03	1.4e-02	6.11	6.6	3.4e-11	-0.10	0.01	0.98	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	RSBN1L-AS1	0.34	0.14	enet	25	0.29	2.8e-16	-3.92	6.5	7.9e-11	-0.06	0.15	0.85	FALSE
50	GTEx	Skin Sun Exposed Lower leg	HIP1	0.20	0.01	enet	43	0.04	5.3e-04	-2.87	-7.0	2.9e-12	0.05	0.10	0.03	TRUE
51	GTEx	Skin Sun Exposed Lower leg	POR	0.06	0.02	lasso	3	0.02	4.8e-03	-4.94	-8.7	3.1e-18	-0.13	0.35	0.02	TRUE
52	GTEx	Skin Sun Exposed Lower leg	TMEM60	0.10	0.10	lasso	3	0.09	1.4e-07	6.11	6.1	9.9e-10	-0.11	0.04	0.96	FALSE
53	GTEx	Skin Sun Exposed Lower leg	RSBN1L-AS1	0.25	0.18	enet	22	0.28	4.1e-23	-4.38	5.8	7.5e-09	-0.06	0.68	0.32	FALSE
54	GTEx	Spleen	RSBN1L-AS1	0.36	0.02	enet	20	0.06	1.5e-02	-5.53	5.5	3.1e-08	-0.09	0.04	0.66	FALSE
55	GTEx	Stomach	RSBN1L-AS1	0.11	0.04	enet	5	0.11	9.0e-06	7.09	6.7	1.6e-11	-0.06	0.01	0.98	FALSE
56	GTEx	Testis	MDH2	0.14	0.07	lasso	3	0.05	3.6e-03	-4.94	5.6	2.0e-08	0.07	0.22	0.04	FALSE
57	GTEx	Testis	RSBN1L-AS1	0.16	0.12	lasso	8	0.16	1.5e-07	6.80	6.4	1.4e-10	-0.13	0.02	0.98	FALSE
58	GTEx	Thyroid	TMEM60	0.06	0.04	lasso	8	0.04	8.2e-04	6.09	6.2	4.6e-10	-0.08	0.03	0.97	FALSE
59	GTEx	Uterus	RSBN1L-AS1	0.33	0.08	lasso	7	0.05	3.0e-02	-4.95	6.0	2.1e-09	-0.04	0.06	0.41	FALSE
60	GTEx	Whole Blood	TMEM60	0.05	0.04	enet	7	0.03	5.4e-04	6.59	6.9	3.8e-12	-0.11	0.04	0.96	FALSE
61	GTEx	Whole Blood	ZP3	0.42	0.21	enet	47	0.28	6.0e-26	-3.52	-5.2	1.7e-07	-0.03	1.00	0.00	FALSE
62	METSIM	Adipose	POR	0.04	0.01	bslmm	324	0.01	4.9e-03	-5.14	-8.3	1.3e-16	-0.03	0.18	0.03	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	POR	0.13	0.02	lasso	3	0.09	4.1e-11	-7.63	-10.0	1.1e-23	-0.19	0.72	0.01	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	RSBN1L	0.09	0.07	enet	42	0.08	9.9e-11	7.09	6.1	1.2e-09	-0.13	0.01	0.99	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	ZP3	0.40	0.23	enet	24	0.36	1.3e-48	-3.81	-6.2	5.6e-10	0.04	1.00	0.00	TRUE
66	ROSMAP	Brain Pre-frontal Cortex	TMEM120A	0.05	0.01	bslmm	102	0.02	1.4e-03	-5.85	6.8	1.3e-11	0.12	0.34	0.02	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	RSBN1L-AS1	0.25	0.24	lasso	6	0.26	1.3e-33	-3.98	5.5	3.9e-08	-0.03	1.00	0.00	FALSE
68	ROSMAP	Brain Pre-frontal Cortex	AC005077.14	0.04	0.04	lasso	7	0.04	6.9e-06	-5.71	-5.2	1.7e-07	-0.15	0.87	0.01	FALSE
69	YFS	Blood	HSPB1	0.35	0.02	enet	49	0.16	1.5e-49	0.28	-6.5	6.3e-11	0.01	1.00	0.00	FALSE
70	YFS	Blood	MDH2	0.01	0.00	enet	4	0.01	3.1e-03	-6.51	6.3	2.4e-10	0.12	0.32	0.02	TRUE
71	YFS	Blood	POR	0.15	0.12	enet	19	0.17	2.8e-53	-5.14	-9.1	9.9e-20	-0.17	1.00	0.00	FALSE
72	YFS	Blood	TMEM60	0.14	0.16	lasso	4	0.18	1.8e-55	6.11	6.9	6.1e-12	-0.09	0.01	0.99	FALSE
73	The Cancer Genome Atlas	Breast Invasive Carcinoma	POR	0.02	0.00	blup	16	0.01	1.6e-03	-7.63	-10.2	1.6e-24	-0.20	0.01	0.55	TRUE
74	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM60	0.02	0.02	lasso	1	0.02	2.3e-05	-5.76	5.8	8.3e-09	-0.07	0.02	0.97	FALSE
75	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MDH2	0.09	0.00	blup	14	0.00	3.4e-01	-5.85	6.6	3.1e-11	0.16	0.00	0.32	TRUE
76	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TMEM60	0.08	0.06	blup	29	0.05	2.1e-03	-5.76	5.7	9.5e-09	-0.08	0.01	0.43	FALSE
77	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM60	0.08	0.02	blup	29	0.04	1.2e-05	6.80	6.7	1.5e-11	-0.08	0.00	0.99	FALSE
78	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MDH2	0.03	0.03	enet	5	0.02	9.7e-04	-5.85	6.2	4.0e-10	0.16	0.01	0.94	FALSE
79	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	POR	0.04	0.00	enet	7	0.02	2.1e-03	8.58	-7.2	6.3e-13	-0.19	0.00	0.74	FALSE
80	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM60	0.05	0.01	enet	7	0.02	1.9e-03	6.59	6.3	3.8e-10	-0.10	0.00	0.98	FALSE
81	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM60	0.05	0.02	blup	29	0.03	7.9e-03	-5.76	6.2	4.0e-10	-0.09	0.01	0.73	FALSE
82	The Cancer Genome Atlas	Brain Lower Grade Glioma	RSBN1L	0.02	0.02	blup	58	0.02	3.4e-03	6.11	-5.6	1.8e-08	0.11	0.03	0.78	FALSE
83	The Cancer Genome Atlas	Lung Adenocarcinoma	MDH2	0.03	0.04	lasso	4	0.04	2.2e-05	-5.85	6.0	2.0e-09	0.15	0.01	0.99	FALSE
84	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM60	0.02	0.03	blup	29	0.02	6.8e-03	-5.76	6.4	1.5e-10	-0.09	0.01	0.82	FALSE
85	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM60	0.12	0.05	blup	29	0.02	3.1e-02	6.79	6.8	1.3e-11	-0.11	0.00	0.87	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	MDH2	0.02	0.03	lasso	2	0.03	8.4e-04	-5.85	5.9	4.5e-09	0.14	0.01	0.88	TRUE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM60	0.03	0.01	blup	29	0.01	1.1e-02	6.11	6.5	1.0e-10	-0.06	0.01	0.48	FALSE
88	The Cancer Genome Atlas	Soft Tissue Sarcoma	MDH2	0.03	0.04	lasso	3	0.04	2.8e-03	-5.93	5.9	3.1e-09	0.16	0.01	0.77	FALSE
89	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM60	0.20	0.01	enet	15	0.06	2.4e-05	6.59	5.2	1.6e-07	-0.10	0.01	0.58	FALSE
90	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM60	0.12	0.06	enet	6	0.06	1.2e-06	6.11	5.9	2.9e-09	-0.12	0.01	0.99	FALSE
91	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	MDH2	0.11	0.10	lasso	1	0.09	1.6e-03	-5.85	5.8	4.9e-09	0.14	0.01	0.61	FALSE