Hub : Genes

CCM2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.2140 0.0830 4.9e-03 0.058 NA 0.054 NA 0.065 8.3e-03 NA 1.1e-02 NA 5.5e-03
2 GTEx Lung 0.1022 0.0347 4.4e-04 0.061 NA 0.032 NA 0.042 1.8e-05 NA 1.7e-03 NA 3.6e-04
3 GTEx Muscle Skeletal 0.0903 0.0288 9.7e-05 0.088 NA 0.063 NA 0.064 5.5e-09 NA 8.0e-07 NA 7.4e-07
4 GTEx Spleen 0.2860 0.0980 4.5e-03 0.114 NA 0.037 NA 0.069 7.4e-04 NA 4.0e-02 NA 7.8e-03
5 GTEx Whole Blood 0.1240 0.0320 1.1e-07 0.127 NA 0.137 NA 0.133 9.4e-12 NA 1.3e-12 NA 3.0e-12
6 METSIM Adipose 0.0424 0.0172 1.0e-03 0.009 0.019 0.005 0.019 0.008 1.6e-02 5.9e-04 5.5e-02 5.5e-04 1.7e-02
7 ROSMAP Brain Pre-frontal Cortex 0.1182 0.0306 6.9e-09 0.109 0.078 0.098 0.092 0.104 7.1e-14 2.7e-10 1.5e-12 8.1e-12 3.1e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.9 3.0 7.6 -1.4 -1.7 -1.4 -1.4 -1.7 -2.8 1.5
Bipolar Disorder or Schizophrenia 1.7 4.2 8.2 -2.0 -2.1 -2.1 -1.6 -1.8 -2.9 1.6
Depressed Affect (Nagel 2018) 0.6 1.3 2.6 1.1 1.5 1.6 1.0 0.9 0.6 -0.9
Depression (Nagel 2018) 0.8 1.2 2.0 1.0 1.2 1.4 0.9 1.0 1.2 -0.9
Intelligence (Savage-Jansen 2018) 0.3 0.9 3.1 0.3 1.5 1.8 -0.7 -0.0 0.1 0.3
Neuroticism (Nagel 2018) 0.8 1.8 2.3 -1.5 -1.0 -0.8 -1.5 -1.5 -1.5 1.5
Schizophrenia (2018) 0.8 1.6 2.4 -1.5 -1.3 -1.5 -1.0 -1.0 -1.5 0.9
Schizophrenia vs Biploar Disorder 1.5 1.9 2.6 1.2 1.2 0.9 1.4 1.6 1.6 -1.6
Worry (Nagel 2018) 2.1 4.5 6.0 -2.1 -1.5 -1.3 -2.5 -2.4 -2.4 2.3
Alzheimer’s Disease (in mother) 0.2 0.3 0.5 -0.0 0.7 0.4 -0.5 -0.2 0.7 0.7
Alzheimer’s Disease (in father) 1.1 1.2 2.2 -0.4 1.0 1.3 -1.3 -1.2 -0.4 1.5
Alzheimer’s Disease (including proxy) 0.6 0.8 2.0 -0.0 1.4 1.1 -0.9 -0.6 0.2 1.0
Crohns Disease (2017) 1.9 4.2 6.8 -2.2 -2.2 -2.6 -1.3 -1.7 -2.6 1.4
Irritable Bowel Disease (IBD) 0.7 1.6 4.7 -1.2 -0.9 -1.5 -0.8 -0.9 -2.2 0.8
Ulcerative Colitis (UC) 0.2 0.4 2.4 -0.1 0.5 -0.1 -0.5 -0.2 -1.5 0.3
Major Depression (MDD) 0.7 0.9 1.3 0.9 1.2 1.2 0.6 1.0 0.4 -1.0
Reaction Time 1.6 3.0 7.6 1.4 0.9 1.0 1.6 1.9 2.8 -2.0
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.6 0.2 0.4 0.7 -0.4 0.3 -0.5 -0.2
Breast Cancer 0.1 0.2 0.7 -0.2 -0.3 -0.3 -0.4 -0.3 0.9 0.1
Ovarian Cancer 0.2 0.3 1.3 0.4 1.1 0.7 -0.1 -0.0 -0.3 -0.5
Prostate Cancer 0.7 1.0 1.4 1.1 1.2 0.7 1.2 1.1 -0.1 -1.1
Age at First Birth 2.2 3.2 8.5 -1.0 -0.4 -0.4 -1.9 -1.9 -2.9 2.3
Bipolar Disorder (2011) 3.6 3.5 5.4 -1.9 -1.2 -1.4 -1.9 -2.3 -2.2 1.9
Body Mass Index (BMI) (2010) 3.5 4.8 7.1 2.2 1.6 1.6 2.6 2.7 2.1 -2.2
Coronary Artery Disease (CAD) 0.7 0.9 1.9 0.7 1.4 1.3 -0.5 -0.1 -1.2 -0.3
Crohns Disease (2012) 1.3 2.1 4.8 -1.5 -1.8 -2.2 -0.5 -0.9 -1.6 0.7
Mean Putamen Volume 2.8 3.2 7.2 1.8 2.7 2.6 0.8 1.0 1.6 -1.1
Fasting Glucose 1.5 1.8 4.9 1.1 1.2 1.3 1.0 1.1 2.2 -1.1
HbA1C 0.6 0.6 1.6 -0.6 -1.3 -1.1 -0.3 -0.7 -0.7 0.3
HDL Cholesterol 0.9 1.5 4.0 1.4 2.0 1.7 0.4 0.7 0.8 -0.9
LDL Cholesterol 0.3 0.5 0.9 -0.3 0.4 0.7 -0.8 -0.4 0.8 0.9
Lupus 0.9 1.4 4.3 -1.2 -2.1 -1.7 -0.3 -0.5 0.3 0.6
Neuroticism (2016) 4.7 6.7 8.5 -2.8 -2.1 -2.4 -2.3 -2.9 -2.9 2.6
Primary Biliary Cirrhosis 2.6 3.6 5.6 2.1 1.8 2.4 1.9 2.0 1.0 -1.9
Rheumatoid Arthritis 1.0 1.3 2.1 1.3 0.7 1.3 1.0 1.2 1.4 -1.1
Schizophrenia (2014) 0.6 1.3 2.1 -1.3 -1.2 -1.5 -0.8 -0.8 -1.4 0.7
Triglycerides 0.4 0.6 1.0 -0.9 -1.0 -0.8 -0.5 -0.3 -0.8 0.8
Type 2 Diabetes (T2D) (2012) 4.7 5.5 9.7 2.2 1.9 1.3 2.3 2.3 3.1 -2.8
Ulcerative Colitis 0.4 0.6 2.1 -0.3 0.4 0.2 -0.8 -0.6 -1.4 0.8
Blood Eosinophil Count 6.0 45.9 75.9 6.7 3.1 3.1 8.7 8.3 6.5 -8.4
Blood Platelet Count 0.8 9.6 26.7 -1.9 -5.1 -5.2 0.9 -0.3 3.1 -1.0
Blood Red Count 0.3 3.3 8.1 -1.5 -1.9 -2.0 -1.1 -1.5 2.9 1.1
Blood White Count 1.9 14.2 42.0 -0.9 -5.2 -6.5 3.6 2.0 0.7 -3.3
Heel T-Score 0.4 3.3 7.2 0.8 -0.6 -1.2 2.5 2.1 1.7 -2.7
BMI 1.2 6.8 12.7 2.5 0.5 0.6 3.6 3.2 2.8 -3.2
Height 0.2 4.3 16.4 1.4 3.3 4.0 -0.6 0.6 0.1 0.4
Waist Hip Ratio (WHR) 1.9 8.6 11.0 3.1 2.9 2.5 3.3 3.3 2.6 -2.8
Systolic Blood Pressure 2.0 10.1 14.8 3.3 2.5 3.1 3.2 3.0 3.9 -3.1
Smoking Status 2.2 5.3 7.6 2.8 2.4 2.4 2.4 2.4 1.2 -2.1
Allergy or Eczema 0.6 1.5 3.6 1.0 -0.1 0.1 1.9 1.7 1.1 -1.4
Cardiovascular Disease 1.6 5.3 12.0 2.3 1.1 1.7 2.4 2.4 3.5 -2.2
Hypothyroidism (self reported) 0.3 0.7 1.5 1.1 -0.3 0.4 1.2 1.0 -0.1 -1.1
Respiratory disease 3.9 8.7 16.6 3.0 1.8 1.9 4.1 3.3 2.5 -3.4
Type 2 Diabetes (T2D) (2018) 1.2 2.3 8.4 1.2 1.0 1.1 1.2 1.1 2.9 -1.2
Lung FEV1/FVC ratio 0.1 0.7 1.9 0.7 1.0 0.9 0.3 0.6 1.4 -0.6
Lung FVC 1.3 6.6 11.4 -2.8 -2.9 -3.4 -1.8 -2.2 -2.5 2.0
Neuroticism 1.0 2.4 3.4 -1.7 -1.1 -1.3 -1.4 -1.8 -1.8 1.6
Chronotype (morning person) 3.8 8.9 16.3 -3.2 -3.3 -4.0 -2.2 -2.5 -2.9 2.2
Hair Pigment 0.0 0.9 1.6 0.9 0.4 0.5 1.1 1.2 1.2 -1.0
Tanning 0.0 0.2 0.3 -0.0 0.4 0.5 -0.6 -0.2 0.5 0.2
Hand grip strength (left) 0.1 0.1 0.5 0.3 0.5 0.7 -0.3 0.1 0.0 0.1
Number of treatments/medications taken 2.4 4.3 5.6 2.2 1.2 1.6 2.2 2.3 2.4 -2.3
Average weekly spirits intake 1.1 1.3 2.4 1.0 0.8 0.5 1.1 1.4 1.4 -1.6
Sensitivity / hurt feelings 0.7 1.3 2.5 -1.4 -1.4 -1.6 -0.8 -0.8 -0.1 1.0
Frequency of depressed mood in last 2 weeks 2.1 2.9 5.7 1.8 2.1 2.4 1.3 1.5 1.2 -1.3
Hearing difficulty/problems: Yes 0.8 1.2 2.2 1.1 0.8 0.3 1.4 1.5 0.0 -1.5
Relative age of first facial hair 1.2 2.6 4.9 1.3 0.8 0.5 2.1 2.2 1.1 -2.2
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.7 0.8 -0.0 0.3 0.8 0.8 0.7 -0.6
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.0 0.5 1.0 0.7 -0.3 -0.2 0.5 0.1
Ever had hysterectomy (womb removed) 0.3 0.3 0.6 -0.7 -0.1 -0.4 -0.6 -0.8 -0.2 0.7
Systolic blood pressure, automated reading 2.5 7.3 9.5 3.0 2.1 2.4 2.8 2.7 3.1 -2.7
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 1.6 -1.3 -1.1 -1.1 -1.3 -1.3 -0.8 1.1
Angina 0.7 0.9 1.0 -0.8 -0.9 -1.0 -0.9 -0.9 -0.9 1.0
Medication for hormone replacement therapy 0.1 0.1 0.3 -0.3 -0.5 -0.5 -0.4 -0.4 0.0 0.3
Vitamin and mineral supplements 0.4 0.6 1.4 0.7 1.2 1.0 0.5 0.8 0.1 -0.6
Supplements: Zinc 0.0 0.1 0.3 -0.1 0.1 0.1 -0.0 -0.1 -0.5 0.2
Medication: Co-codamol 0.1 0.2 0.4 0.2 -0.4 -0.3 0.4 0.3 0.6 -0.4
Medication: Metformin 0.4 0.6 2.6 0.1 1.0 0.8 0.1 -0.1 1.6 0.1
Diabetes (father) 1.7 2.1 3.3 1.3 0.3 0.7 1.8 1.7 1.6 -1.8
Diabetes (mother) 1.0 1.3 3.1 1.1 1.4 1.8 0.7 0.6 1.4 -0.3
Severe depression (siblings) 0.8 0.9 2.2 -0.9 -1.3 -1.1 -0.3 -0.5 -1.5 0.5
Pack years adult smoking proportion 1.4 2.1 2.9 1.6 1.2 1.0 1.7 1.4 1.5 -1.6
Impedance of leg (right) 1.4 6.6 12.7 2.5 3.6 3.5 1.5 2.0 2.5 -1.6
Leg fat-free mass (left) 0.1 0.3 1.0 -0.5 -1.0 -0.7 -0.3 -0.4 -0.5 0.3
Trunk fat percentage 2.3 9.4 11.9 3.3 2.3 2.4 3.3 3.4 3.4 -3.1
Hand grip strength (right) 0.1 0.3 1.0 0.3 0.6 1.0 -0.6 0.1 0.6 0.5
Townsend deprivation index at recruitment 2.2 3.1 6.2 1.7 1.6 0.7 1.8 1.6 2.5 -2.1
Current tobacco smoking 8.4 13.7 17.5 4.2 3.9 3.8 3.7 3.7 2.6 -3.8
Average weekly fortified wine intake 0.8 1.0 2.6 -0.7 -0.3 -0.0 -1.6 -1.2 -0.4 1.4
Maternal smoking around birth 1.8 2.6 4.2 1.9 1.2 1.0 1.7 2.1 1.2 -1.8
Fed-up feelings 0.2 0.3 0.8 0.5 0.9 0.8 0.3 0.2 0.1 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.1 2.8 1.5 1.1 1.3 1.5 1.5 1.7 -1.5
Relative age voice broke 2.0 3.1 4.2 1.9 1.8 1.6 2.0 2.0 0.7 -1.9
Taking other prescription medications 2.4 3.6 6.1 2.2 1.1 1.3 2.5 2.3 1.3 -2.2
Age when periods started (menarche) 0.7 1.6 2.2 -1.3 -1.5 -1.2 -1.0 -1.0 -1.3 1.3
Bilateral oophorectomy (both ovaries removed) 2.8 3.2 5.1 -2.3 -1.6 -1.9 -1.7 -2.0 -1.2 1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 4.2 0.9 0.0 -0.8 1.9 1.6 0.6 -2.0
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.6 -0.4 -0.4 -0.2 -0.7 -0.5 1.3 0.6
Qualifications: CSEs or equivalent 0.4 0.5 1.4 0.4 0.0 -0.3 1.2 1.0 0.6 -0.9
Serious illness, injury or assault to yourself 1.0 1.3 2.2 -1.0 -1.0 -1.3 -0.9 -1.1 -1.5 0.9
High blood pressure 1.0 2.7 9.2 1.5 1.3 1.7 0.9 1.1 3.0 -1.1
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.7 0.6 -0.1 0.1 1.3 1.1 0.7 -0.8
Multivitamins +/- minerals 0.2 0.2 0.5 -0.4 -0.4 -0.2 -0.7 -0.7 0.3 0.4
Stomach or abdominal pain in last month 0.5 0.6 1.8 -0.6 -1.3 -1.1 -0.2 -0.2 -0.6 0.2
Supplements: Glucosamine 0.8 1.1 1.8 -0.9 -1.1 -0.8 -1.0 -1.1 -1.1 1.3
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.5 0.7 0.1 0.0 1.0 1.2 1.2 -1.1
Medication: Atenolol 0.2 0.2 0.5 -0.4 -0.7 -0.6 -0.5 -0.1 -0.5 0.1
Medication: Levothyroxine sodium 1.4 2.3 3.7 1.9 0.8 1.5 1.7 1.9 0.5 -1.7
Sitting height 0.5 3.8 9.5 -1.5 0.0 0.5 -3.1 -2.3 -1.4 2.7
Chronic bronchitis/emphysema (father) 3.0 3.5 5.7 2.0 1.3 1.1 2.2 2.4 1.0 -2.4
High blood pressure (mother) 0.6 0.8 3.0 -0.4 -1.3 -1.7 0.7 0.5 -0.1 -0.5
Body mass index (BMI) 0.4 1.7 3.2 1.0 -0.4 -0.2 1.8 1.4 1.7 -1.5
Impedance of leg (left) 1.2 6.0 12.7 2.3 3.6 3.5 1.2 1.8 2.2 -1.4
Leg predicted mass (left) 0.1 0.4 1.1 -0.6 -1.1 -0.8 -0.3 -0.4 -0.5 0.4
Trunk fat mass 1.6 7.0 9.7 2.8 2.0 2.1 2.8 2.9 3.1 -2.6
Waist circumference 1.7 6.1 8.8 2.7 1.7 1.8 3.0 2.8 2.5 -2.6
Number of incorrect matches in round 1.6 2.7 4.0 1.8 1.6 1.9 1.2 1.5 2.0 -1.4
Past tobacco smoking 1.0 1.8 3.0 -1.7 -1.2 -1.0 -1.6 -1.7 -0.3 1.4
Alcohol usually taken with meals 0.9 1.5 2.9 -0.8 0.0 0.4 -1.7 -1.4 -1.4 1.7
Nervous feelings 0.5 1.0 1.6 -0.9 -0.8 -0.9 -0.9 -1.0 -1.3 1.0
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 2.2 0.6 1.5 1.4 -0.2 -0.1 1.0 0.1
Hearing difficulty/problems with background noise 0.1 0.1 0.3 -0.3 -0.1 -0.5 0.2 0.3 -0.5 -0.3
Hair/balding pattern: Pattern 2 0.3 0.4 0.9 -0.8 -0.4 -0.2 -0.8 -0.9 0.5 0.7
Had menopause 0.6 0.8 1.5 -0.8 -0.3 -0.6 -1.2 -1.1 -0.8 1.0
Had other major operations 0.3 0.4 1.0 0.5 -0.5 -0.1 1.0 0.9 -0.1 -0.8
Forced vital capacity (FVC) 1.0 3.7 4.7 -2.2 -2.2 -2.1 -1.8 -1.6 -2.0 1.7
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.7 0.5 0.2 -0.7 1.2 1.0 0.5 -1.3
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.6 -0.1 0.5 0.8 -0.5 -0.6 0.3 0.7
Qualifications: None of the above 2.3 4.9 7.2 2.1 1.3 1.1 2.5 2.7 2.5 -2.7
Financial difficulties in last 2 years 0.1 0.2 0.9 0.2 -0.3 0.1 0.1 -0.3 -0.9 0.2
Mouth/teeth dental problems 0.3 0.5 1.0 -0.7 -0.9 -0.4 -0.9 -0.6 -0.1 1.0
Heart attack 0.0 0.1 0.2 0.1 0.1 0.2 -0.5 -0.1 0.3 0.2
Allergy 0.9 2.2 4.4 -1.3 -0.4 -0.6 -2.1 -1.9 -1.5 1.7
Pain all over the body in last month 0.1 0.1 0.8 0.1 -0.2 -0.1 0.3 0.1 -0.9 -0.2
Diabetes (self-reported) 0.3 0.5 3.4 -0.1 0.0 0.1 -0.1 -0.2 1.8 0.2
Hayfever/allergic rhinitis (self-reported) 3.2 4.2 7.6 2.4 1.2 1.4 2.7 2.8 0.6 -2.3
Medication: Ramipril 0.1 0.1 0.5 0.2 0.1 0.7 -0.1 -0.1 0.5 -0.3
Medication: Simvastatin 1.2 1.7 7.0 1.1 1.0 1.4 0.4 0.5 2.6 -0.5
Fluid intelligence score 0.2 0.3 1.0 0.4 0.5 1.0 -0.6 -0.1 -0.7 0.1
Illnesses of siblings 0.8 1.1 5.0 -0.3 -0.5 -0.1 -0.9 -1.0 -2.2 0.9
Neuroticism score 0.9 2.0 2.7 -1.5 -0.9 -1.1 -1.4 -1.6 -1.5 1.6
Weight 0.3 1.4 2.2 1.2 0.5 0.8 1.4 1.4 1.5 -1.2
Impedance of arm (right) 1.4 6.7 8.8 2.9 3.0 2.7 2.5 2.7 1.5 -2.7
Arm fat percentage (right) 1.8 7.3 10.8 2.9 1.6 1.7 3.3 3.1 2.9 -2.9
Trunk fat-free mass 0.2 1.4 2.1 -1.2 -0.9 -0.6 -1.5 -1.4 -0.9 1.4
Hip circumference 0.3 1.3 2.1 1.4 0.3 0.8 1.5 1.4 0.8 -1.4
Time employed in main current job 3.4 3.9 7.5 -2.2 -2.7 -2.3 -1.6 -1.8 -1.0 1.7
Alcohol intake versus 10 years previously 0.0 0.1 0.1 0.2 0.3 0.3 -0.2 0.1 0.3 0.2
Father’s age at death 4.6 6.2 11.2 -2.5 -1.9 -2.0 -2.4 -2.5 -3.3 2.5
Worrier / anxious feelings 1.9 3.6 4.9 -2.2 -2.1 -2.0 -2.0 -2.0 -1.0 1.8
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 2.5 1.4 1.5 1.6 1.0 1.1 0.6 -1.0
Falls in the last year 0.4 0.6 1.1 -0.8 -0.9 -0.7 -1.0 -0.8 0.4 0.6
Hair/balding pattern: Pattern 3 0.4 0.5 1.4 0.5 -0.4 -0.3 0.8 1.1 -0.3 -1.2
Number of live births 0.2 0.2 0.6 0.3 0.1 0.0 0.5 0.8 0.2 -0.8
Forced expiratory volume in 1-second (FEV1) 1.2 4.0 5.4 -2.3 -2.1 -2.0 -2.0 -1.8 -1.7 1.9
Pulse rate 1.5 2.6 5.1 1.8 1.7 2.2 1.3 1.6 1.1 -1.2
Happiness 0.3 0.4 0.6 -0.1 0.6 0.7 -0.8 -0.5 -0.7 0.6
Noisy workplace 0.1 0.1 0.4 -0.6 -0.0 -0.2 -0.2 -0.4 -0.1 0.6
Qualifications: A levels/AS levels or equivalent 2.0 4.4 7.3 -1.9 -1.7 -1.1 -2.3 -2.4 -2.7 2.2
Serious illness, injury or assault of a close relative in last 2 years 2.7 3.2 4.6 -1.9 -1.7 -1.4 -2.1 -1.9 -1.3 2.0
Mouth/teeth dental problems: Dentures 1.5 2.5 3.5 1.7 1.4 1.5 1.4 1.5 1.9 -1.5
Asthma 1.6 3.2 5.4 1.8 1.1 1.2 2.3 2.0 1.6 -2.1
Medication: Ibuprofen (e.g. Nurofen) 2.2 2.8 5.5 -1.6 -0.7 -0.3 -2.3 -2.2 -0.8 2.3
Medication: Cholesterol lowering 1.1 1.7 5.8 0.9 1.4 1.8 -0.2 0.0 2.4 -0.1
Depression (self-reported) 0.3 0.4 2.0 0.4 0.4 0.4 0.3 0.1 -1.4 -0.3
Medication: Lansoprazole 0.1 0.2 0.5 0.2 -0.4 -0.3 0.7 0.3 -0.0 -0.4
Prospective memory result 0.6 0.8 1.4 -1.1 -0.9 -1.2 -0.5 -0.7 -0.8 0.8
Lung cancer (father) 0.5 0.6 1.3 0.7 1.0 0.7 0.6 0.4 1.2 -0.4
Illnesses of mother 0.8 1.0 1.4 -1.1 -1.0 -0.7 -1.2 -1.2 -1.2 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 2.6 8.3 11.0 -3.3 -3.1 -2.9 -2.9 -2.8 -2.3 2.9
Pulse wave Arterial Stiffness index 0.3 0.4 0.9 -0.5 -0.2 -0.3 -0.5 -0.9 -0.5 0.9
Impedance of arm (left) 1.8 8.5 12.6 3.2 3.6 3.4 2.5 2.9 1.8 -2.7
Arm fat mass (right) 1.0 4.2 6.2 2.1 1.2 1.3 2.5 2.3 2.4 -2.2
Trunk predicted mass 0.2 1.3 2.1 -1.2 -0.9 -0.5 -1.4 -1.4 -0.9 1.4
Standing height 0.2 1.7 6.5 0.8 2.1 2.5 -0.6 0.2 0.1 0.3
Length of working week for main job 0.7 0.8 1.9 -1.0 -1.2 -1.4 -0.4 -0.6 -0.3 0.6
Exposure to tobacco smoke at home 0.6 0.7 1.6 -0.6 0.0 0.0 -1.3 -1.1 -0.5 1.2
Breastfed as a baby 1.9 2.3 3.2 1.7 1.4 1.4 1.2 1.5 1.8 -1.5
Tense / ‘highly strung’ 1.9 3.1 5.5 -1.7 -0.6 -0.5 -2.4 -2.2 -1.5 2.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.4 -0.5 -0.2 -0.1 -0.4 -0.3 -0.6 0.6
Hair/balding pattern: Pattern 4 0.8 2.0 4.8 -1.1 -0.4 -0.1 -1.9 -1.6 -1.2 2.2
Birth weight of first child 0.9 1.6 2.9 1.7 0.9 1.2 1.1 1.4 1.2 -1.2
Peak expiratory flow (PEF) 0.7 1.6 2.4 -1.6 -1.0 -1.1 -1.3 -1.3 -1.1 1.4
Pulse wave reflection index 1.4 1.8 3.0 -1.5 -0.8 -1.2 -1.4 -1.7 -1.2 1.3
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.2 -0.5 0.5 0.2 -1.1 -1.0 0.6 0.9
Loud music exposure frequency 0.2 0.2 1.3 -0.1 -0.2 0.0 0.2 0.0 1.1 -0.1
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 2.9 -1.3 -0.9 -0.5 -1.5 -1.5 -1.7 1.4
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 1.3 0.3 1.2 0.7 0.5 0.3 0.1 -0.2
Blood clot in the leg (DVT) 3.4 4.4 5.5 2.2 2.2 2.0 1.8 1.9 2.3 -2.0
Medication: Paracetamol 1.6 2.7 3.9 -1.8 -2.0 -1.7 -1.5 -1.5 -1.6 1.5
Headache pain in last month 1.6 2.7 4.2 -1.6 -1.8 -2.0 -1.3 -1.7 -1.6 1.3
Medication for cholesterol, blood pressure or diabetes 3.9 6.4 11.4 -2.6 -2.9 -3.1 -1.4 -1.8 -3.4 1.8
Glaucoma (self-reported) 0.7 0.8 1.7 -0.7 -0.5 -0.8 -0.9 -1.0 -1.0 1.3
Gout (self-reported) 0.2 0.3 1.1 0.1 1.0 0.7 -0.3 -0.4 -0.2 0.1
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.4 1.2 -0.2 0.5 1.1 1.1 -0.3 -1.1
Medication: Amlodipine 0.5 0.7 1.6 0.7 0.2 0.2 1.3 1.0 0.4 -1.1
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.3 1.0 0.7 0.7 0.8 1.1 1.1 -1.1
Birth weight 0.1 0.2 0.6 -0.5 -0.6 -0.4 -0.2 0.2 0.8 0.0
Chronic bronchitis/emphysema (mother) 1.4 1.6 3.1 1.8 1.0 1.1 1.5 1.5 0.3 -1.2
High blood pressure (siblings) 0.4 0.6 1.2 0.0 -0.3 -0.6 1.1 0.9 0.9 -0.9
Forced vital capacity (FVC), Best measure 1.7 6.2 8.4 -2.8 -2.9 -2.6 -2.2 -2.2 -2.4 2.2
Body fat percentage 2.5 9.8 12.9 3.3 2.4 2.4 3.4 3.4 3.6 -3.1
Leg fat percentage (right) 1.6 5.7 9.6 2.4 1.4 1.5 2.7 2.6 3.1 -2.4
Arm fat-free mass (right) 0.1 0.5 0.9 -0.8 -0.5 -0.2 -0.9 -0.8 0.2 0.9
Exposure to tobacco smoke outside home 1.0 1.3 1.9 -1.1 -0.7 -0.7 -1.4 -1.3 1.2 1.4
Comparative body size at age 10 0.2 0.4 1.0 -0.0 -0.8 -1.0 0.6 0.6 0.0 -0.7
Number of full brothers 0.2 0.2 0.6 0.3 0.5 0.0 0.3 0.5 0.8 -0.6
Worry too long after embarrassment 4.6 7.7 10.1 -3.1 -2.3 -2.5 -2.9 -3.0 -2.2 3.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 3.9 1.5 0.6 0.3 2.0 1.5 0.1 -1.5
Wheeze or whistling in the chest in last year 5.0 9.0 15.6 3.2 1.8 1.5 3.9 3.5 2.4 -3.7
Number of children fathered 3.7 4.2 5.0 -2.2 -2.1 -2.1 -2.1 -2.1 -1.4 2.2
Reason for reducing amount of alcohol drunk: Health precaution 2.1 2.4 5.5 -1.4 -0.5 -0.3 -2.2 -2.0 0.2 2.3
Age at first live birth 0.9 1.7 3.2 -0.9 -0.1 0.0 -1.8 -1.7 -1.4 1.6
Pulse wave peak to peak time 0.5 0.6 1.2 0.7 0.5 0.5 0.7 1.1 0.7 -1.1
Health satisfaction 0.2 0.2 1.1 0.1 0.2 0.3 -0.5 -0.2 1.0 0.3
Shortness of breath walking on level ground 0.6 0.7 1.2 -0.9 -0.8 -0.3 -1.1 -1.1 -0.2 1.1
Qualifications: College or University degree 2.2 6.9 13.1 -2.5 -2.1 -1.9 -2.5 -2.9 -3.6 2.6
Eye problems/disorders: None of the above 0.1 0.2 0.4 -0.2 -0.5 -0.6 0.2 0.1 -0.6 -0.2
Mouth/teeth dental problems: Loose teeth 1.1 1.3 2.2 1.2 0.9 0.3 1.3 1.5 0.6 -1.5
Emphysema/chronic bronchitis 1.8 2.0 3.6 1.3 1.4 1.3 1.4 1.2 1.9 -1.4
Medication for pain relief, constipation, heartburn 0.2 0.3 0.9 -0.7 -0.2 -0.4 -0.3 -0.6 -0.9 0.4
Neck or shoulder pain in last month 0.8 1.1 1.8 -1.0 -1.3 -1.1 -1.0 -1.0 -0.8 1.0
Medication: Blood pressure 2.0 3.5 6.4 1.9 2.2 2.3 0.9 1.3 2.5 -1.3
Angina (self-reported) 0.5 0.7 1.0 -0.7 -0.8 -0.8 -0.9 -0.8 -0.8 1.0
Migraine (self-reported) 0.5 0.7 1.1 -1.1 -0.8 -0.8 -1.0 -0.8 -0.4 0.7
Medication: Ibuprofen 3.7 4.5 8.4 -2.2 -1.1 -0.8 -2.7 -2.7 -1.1 2.9
Medication: Allopurinol 0.2 0.3 0.4 -0.0 0.6 0.5 -0.6 -0.6 0.6 0.4
Medication: Omeprazole 9.4 11.2 14.9 3.6 2.4 2.1 3.7 3.9 3.5 -3.8
Medication: Seretide 50 evohaler 2.5 2.8 6.1 1.5 1.6 1.6 1.6 1.6 2.5 -1.1
Mean time to correctly identify matches 1.5 2.9 9.4 1.2 0.7 0.9 1.4 1.7 3.1 -1.7
Heart disease (mother) 0.8 1.0 2.1 1.0 0.5 0.5 1.5 0.7 1.4 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.7 0.5 0.6 0.4 0.8 0.6 0.1 -0.6
Whole body fat mass 1.6 6.5 9.6 2.7 1.9 2.0 2.7 2.8 3.1 -2.5
Leg fat mass (right) 1.2 4.6 7.7 2.2 1.2 1.4 2.5 2.4 2.8 -2.2
Arm predicted mass (right) 0.1 0.3 0.5 -0.5 -0.2 0.1 -0.7 -0.5 0.4 0.7
Pulse rate, automated reading 0.5 1.6 3.3 1.3 1.4 1.8 0.8 1.0 1.5 -0.6
Alcohol intake frequency. 0.4 0.9 2.9 -0.7 -1.4 -1.7 0.4 0.1 0.7 -0.3
Comparative height size at age 10 0.2 1.2 3.5 1.0 1.4 1.9 0.1 0.7 1.0 -0.5
Number of full sisters 0.5 0.6 1.1 0.7 0.1 0.4 0.8 1.0 0.7 -1.0
Suffer from ‘nerves’ 0.5 0.8 3.5 -0.4 -0.3 -0.1 -0.8 -0.7 -1.9 0.7
Overall health rating 0.1 0.2 0.3 0.5 0.5 0.5 0.4 0.3 0.5 -0.2
Chest pain or discomfort 0.4 0.6 1.3 -0.0 -0.8 -1.2 0.8 0.4 0.8 -0.8
Had major operations 0.6 0.8 1.6 -0.7 -0.5 -0.2 -1.2 -1.0 -0.7 1.3
Age at last live birth 1.6 2.3 3.3 -1.6 -1.3 -1.3 -1.7 -1.8 -1.0 1.6
Family relationship satisfaction 0.4 0.5 0.9 0.8 0.9 0.6 0.6 0.7 -0.5 -0.7
Leg pain on walking 1.4 1.8 4.0 1.0 0.6 0.5 1.7 1.4 2.0 -1.4
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 2.7 -1.5 -1.6 -1.5 -1.0 -1.1 -0.4 1.1
Commuting to job workplace: Car/motor vehicle 5.1 5.9 8.4 2.3 1.5 2.0 2.8 2.9 2.7 -2.4
Illness, injury, bereavement, stress in last 2 years 3.0 3.7 5.0 2.0 1.9 1.8 1.9 2.2 1.4 -2.1
Medication: Aspirin 1.1 1.4 2.0 1.4 0.8 1.0 1.2 1.2 1.4 -1.2
Supplements: Vitamin C 1.6 1.9 5.0 -1.4 -2.2 -2.1 -0.5 -0.9 -0.5 0.9
Knee pain experienced in last month 0.4 0.7 1.3 -0.8 -0.2 -0.3 -1.0 -0.9 -0.8 1.2
Hypertension (Self-reported) 1.0 2.7 8.9 1.5 1.2 1.7 0.8 1.1 3.0 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.8 2.1 3.4 1.7 1.0 1.1 1.8 1.7 0.5 -1.7
Illnesses of father: Heart disease 0.3 0.4 0.9 -0.7 -0.9 -0.9 -0.6 -0.3 0.3 0.3
Illnesses of siblings: Diabetes 0.7 0.9 3.3 0.6 0.5 0.3 1.1 0.8 1.8 -0.8
Smoking status: Previous 0.1 0.1 0.3 0.1 -0.3 -0.4 0.3 0.4 -0.5 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.9 2.0 3.3 -1.4 -1.4 -1.5 -1.1 -1.3 -1.8 1.2
Whole body fat-free mass 0.2 1.0 1.3 -1.1 -1.1 -0.8 -1.1 -1.1 -0.7 1.1
Leg fat-free mass (right) 0.2 0.9 1.8 -0.9 -1.3 -1.0 -0.7 -0.8 -0.9 0.8
Arm fat percentage (left) 2.0 8.0 11.1 3.0 1.9 1.9 3.3 3.2 3.1 -3.0
Average weekly red wine intake 1.4 2.1 4.3 -1.4 -1.0 -0.6 -2.1 -1.8 -0.6 1.7
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.2 -0.9 -1.1 -1.0 -0.4 -0.6 -1.1 0.4
Mood swings 0.0 0.1 0.2 -0.5 0.2 -0.4 -0.2 -0.4 -0.1 0.3
Loneliness, isolation 0.2 0.3 0.6 0.4 0.7 0.7 0.5 0.2 -0.8 -0.3
Long-standing illness, disability or infirmity 1.2 1.9 4.5 1.3 0.7 0.7 1.6 1.4 2.1 -1.3
Ever had bowel cancer screening 2.1 2.4 4.9 -1.4 -0.7 -0.4 -2.1 -1.8 -1.4 2.2
Diabetes diagnosed by doctor 0.4 0.7 4.1 0.1 0.6 0.7 -0.2 -0.2 2.0 0.2
Ever had stillbirth, spontaneous miscarriage or termination 4.5 4.8 6.9 -2.3 -1.8 -1.3 -2.6 -2.5 -2.0 2.4
Friendships satisfaction 0.3 0.3 1.3 0.1 0.5 0.5 -0.5 -0.3 -1.1 0.3
Qualifications: nursing, teaching 0.8 1.3 2.0 -1.0 -1.4 -0.9 -1.0 -1.2 -1.3 1.0
Commuting to job workplace: Walk 0.8 0.9 2.6 -0.7 0.3 0.0 -1.0 -1.1 -1.6 1.0
Eye problems/disorders: Cataract 1.9 2.1 4.1 1.5 1.8 2.0 0.8 1.0 1.7 -0.7
Mouth/teeth dental problems: Mouth ulcers 3.2 5.0 9.8 -2.1 -2.8 -3.1 -1.3 -1.6 -2.8 1.0
Medication for cholesterol 0.2 0.3 0.9 0.1 0.9 0.4 -0.1 0.1 -1.0 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.5 -0.4 -0.7 -0.7 -0.4 -0.1 -0.7 0.2
Back pain experienced in last month 3.2 4.6 7.0 -2.5 -1.5 -1.7 -2.6 -2.5 -1.6 2.3
Mineral and other dietary supplements 0.7 0.9 1.9 0.8 0.9 0.4 1.2 1.2 0.2 -1.4
Breast cancer (self-reported) 0.1 0.1 0.3 -0.3 -0.5 -0.6 -0.1 -0.2 -0.2 0.0
Asthma (self-reported) 1.7 3.3 6.0 1.8 1.1 1.1 2.4 2.1 1.6 -2.2
Osteoporosis (self-reported) 0.5 0.6 1.6 -0.5 -1.2 -0.9 -0.1 -0.5 -1.3 0.3
Osteoarthritis (self-reported) 0.9 1.1 2.2 1.3 1.5 1.3 0.9 0.9 0.5 -0.7
Medication: Aspirin 1.0 1.4 2.1 1.4 0.8 1.1 1.2 1.2 1.1 -1.2
Medication: Gliclazide 1.3 1.5 6.6 0.8 1.0 1.3 0.2 0.5 2.6 -0.4
Illnesses of father: None of the above (group 1) 1.0 1.2 2.1 -1.0 -0.6 -0.6 -1.2 -1.4 -1.5 1.3
Smoking status: Current 8.5 13.5 17.4 4.2 3.8 3.9 3.7 3.7 2.6 -3.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 5.3 11.1 13.8 -3.7 -3.5 -3.5 -3.4 -3.4 -2.2 3.4
Whole body water mass 0.1 0.7 1.0 -0.9 -0.9 -0.6 -0.9 -0.9 -0.6 1.0
Leg predicted mass (right) 0.2 0.8 1.6 -0.9 -1.3 -1.0 -0.7 -0.8 -0.9 0.7
Arm fat mass (left) 1.3 5.3 7.1 2.4 1.5 1.6 2.7 2.5 2.7 -2.4
Number of self-reported non-cancer illnesses 1.2 2.0 2.9 1.7 0.7 1.2 1.4 1.6 1.6 -1.5
Average weekly champagne plus white wine intake 0.7 1.0 2.8 -0.5 0.2 0.5 -1.0 -1.1 -1.7 1.2
Miserableness 2.1 3.6 7.5 2.0 2.7 2.6 1.2 1.6 1.4 -1.1
Guilty feelings 0.9 1.4 1.9 -1.3 -0.6 -0.9 -1.3 -1.4 -1.3 1.4
Wears glasses or contact lenses 0.4 0.5 0.9 0.9 0.7 0.9 0.5 0.8 0.3 -0.6
Ever taken oral contraceptive pill 2.0 2.2 4.0 1.5 1.2 0.8 1.8 2.0 0.8 -1.8
Hearing aid user 0.3 0.4 1.1 0.2 -0.2 -0.4 0.5 0.6 1.1 -0.7
Mother’s age at death 3.8 4.7 6.2 -2.5 -2.2 -2.4 -2.2 -2.2 -1.5 1.9
Financial situation satisfaction 0.5 0.6 1.0 -0.1 0.9 1.0 -0.9 -0.7 -0.0 1.0
Tinnitus: Yes, now most or all of the time 1.1 1.2 3.5 1.1 1.9 1.6 0.5 0.7 0.8 -0.5
Commuting to job workplace: Public transport 1.3 1.5 2.6 -1.0 -0.4 -0.6 -1.6 -1.5 -1.6 1.4
Eye problems/disorders: Glaucoma 0.9 1.1 1.6 -1.0 -0.9 -0.9 -1.0 -1.0 -1.1 1.2
Medication: Blood pressure 0.2 0.5 1.7 0.4 -0.0 0.2 0.8 0.5 1.3 -0.6
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.5 0.7 0.0 0.3 1.2 1.1 0.1 -1.1
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.4 0.1 -0.4 -0.2 -0.0 0.0 0.6 0.0
High cholesterol (Self-reported) 0.4 0.7 2.7 0.6 0.6 0.9 0.2 0.6 1.6 -0.4
Medication: Bendroflumethiazide 2.5 3.8 8.7 1.7 1.8 1.8 1.6 1.7 2.9 -1.7
Medication: Paracetamol 1.7 2.6 4.1 -1.8 -2.0 -1.6 -1.3 -1.4 -1.7 1.4
Medication: Lisinopril 0.8 1.0 1.7 1.1 0.6 0.6 1.1 1.1 1.0 -1.3
Medication: Atorvastatin 0.1 0.2 0.2 -0.3 -0.4 -0.1 -0.5 -0.5 0.4 0.5
Illnesses of father: High blood pressure 2.4 3.0 3.9 1.9 1.7 1.4 1.8 2.0 1.3 -1.9
Alcohol drinker status: Never 4.3 5.1 8.5 -2.6 -2.6 -2.9 -1.7 -1.9 -2.1 1.7
Ever smoked 0.7 1.2 2.0 1.4 1.1 0.9 1.2 1.3 0.0 -1.0
Basal metabolic rate 0.0 0.1 0.3 -0.4 -0.5 -0.2 -0.4 -0.4 -0.1 0.5
Leg fat percentage (left) 1.4 4.9 8.4 2.3 1.3 1.5 2.5 2.5 2.9 -2.2
Arm fat-free mass (left) 0.1 0.5 0.7 -0.8 -0.8 -0.5 -0.8 -0.8 0.0 0.9
Number of operations (self-reported) 0.2 0.4 1.2 -0.5 -0.6 -0.3 -0.4 -0.3 -1.1 0.7
Average weekly beer plus cider intake 0.1 0.2 0.4 -0.4 -0.7 -0.4 -0.2 -0.1 -0.6 0.3
Irritability 0.4 0.7 2.1 -0.8 -0.2 -0.8 -0.5 -0.8 -1.5 0.6
Risk taking 1.9 2.8 4.1 -1.8 -1.7 -2.0 -1.2 -1.6 -1.9 1.4
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.0 -0.8 -0.9 -0.7 -0.8 -0.9 -1.4 0.9
Fractured/broken bones in last 5 years 0.4 0.5 1.1 -0.6 0.4 0.1 -0.8 -1.1 -0.4 0.9
Age started oral contraceptive pill 2.3 2.9 5.2 -1.8 -1.1 -1.5 -2.3 -2.1 -0.9 1.8
Diastolic blood pressure, automated reading 1.1 3.4 5.9 2.1 1.1 2.1 1.5 1.9 2.4 -1.4
Ever depressed for a whole week 1.4 1.7 3.3 -1.4 -0.5 -0.6 -1.5 -1.6 -1.2 1.8
Unable to work because of sickness or disability 1.3 1.7 2.8 1.7 1.5 1.6 1.1 1.2 0.6 -1.2
Commuting to job workplace: Cycle 3.2 3.9 4.9 -2.1 -2.2 -2.1 -1.8 -1.7 -2.2 1.8
Myopia 0.2 0.3 0.6 0.8 0.5 0.7 0.5 0.6 -0.1 -0.6
Vascular/heart problems diagnosed by doctor 1.2 3.2 7.7 -1.9 -1.5 -1.9 -1.1 -1.4 -2.8 1.4
Cholesterol lowering medication 0.4 0.6 1.5 0.4 -0.5 -0.3 1.0 0.9 1.2 -0.7
Medication: Omeprazole (e.g. Zanprol) 9.8 12.0 16.0 3.8 2.5 2.2 3.9 4.0 3.5 -4.0
Pain experienced in last month 2.3 3.8 4.8 2.2 1.9 2.1 1.9 2.0 1.7 -1.9
Supplements: Calcium 0.3 0.3 1.2 0.5 0.0 -0.1 1.1 0.6 -0.3 -0.5
Basal cell carcinoma (self-reported) 5.3 6.4 11.1 -2.7 -1.9 -1.5 -3.3 -3.0 -1.7 2.9
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.2 0.3 0.1 0.2 -0.4 0.0 0.4 -0.0
Deep venous thrombosis (DVT) (self-reported) 3.6 4.7 7.3 2.2 2.2 2.1 1.8 1.9 2.7 -2.1
Heart disease (siblings) 2.3 2.8 4.5 -2.1 -1.5 -1.9 -1.8 -1.7 -0.4 1.6
Alcohol drinker status: Previous 0.5 0.5 0.8 0.8 0.7 0.9 0.9 0.7 0.5 -0.7
Pack years of smoking 1.6 2.3 3.4 1.6 1.1 0.8 1.8 1.6 1.6 -1.8
Impedance of whole body 1.7 8.7 15.0 3.1 3.9 3.8 2.1 2.6 2.5 -2.3
Leg fat mass (left) 1.1 4.5 7.5 2.2 1.2 1.4 2.4 2.3 2.7 -2.1
Arm predicted mass (left) 0.1 0.3 0.6 -0.6 -0.4 -0.2 -0.7 -0.7 0.3 0.8