TWAS hub - ZC3HAV1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0770	0.0320	8.9e-03	0.027	NA	0.022	NA	0.023	2.6e-03	NA	6.3e-03	NA	5.3e-03
2	GTEx	Cells Transformed fibroblasts	0.3240	0.0610	3.4e-08	0.143	NA	0.200	NA	0.184	7.5e-11	NA	6.4e-15	NA	9.0e-14
3	ROSMAP	Brain Pre-frontal Cortex	0.1124	0.0277	1.4e-07	0.071	0.054	0.082	0.066	0.074	1.8e-09	1.6e-07	9.5e-11	6.9e-09	9.6e-10
4	YFS	Blood	0.3200	0.0364	0.0e+00	0.143	0.225	0.240	0.238	0.231	2.6e-44	3.4e-72	2.4e-77	1.4e-76	2.7e-74
5	TCGA	Brain Lower Grade Glioma	0.0906	0.0373	5.6e-06	0.017	0.053	0.048	NA	0.027	3.9e-03	1.1e-06	3.4e-06	NA	4.0e-04
6	TCGA	Lung Adenocarcinoma	0.0328	0.0179	3.4e-03	0.005	0.009	0.009	NA	0.006	8.0e-02	2.8e-02	2.8e-02	NA	5.7e-02
7	TCGA	Lung Squamous Cell Carcinoma	0.0387	0.0220	5.1e-03	0.009	0.020	0.005	NA	0.010	3.0e-02	2.4e-03	8.4e-02	NA	2.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2011)	10.2	9.9	13.4	-3.4	-2.5	-3.7	-2.9	-2.9	-3.2	-3.4
Primary Biliary Cirrhosis	7.3	10.3	17.7	4.2	2.2	3.9	1.6	2.1	4.0	3.4
Hypothyroidism/myxoedema (self-reported)	4.8	9.5	15.2	3.5	2.9	3.5	0.2	3.0	3.0	3.9
Basal cell carcinoma (self-reported)	4.3	5.1	7.3	2.7	1.8	2.6	1.8	1.4	2.5	2.6
Smoking status: Previous	4.0	6.0	9.1	-2.7	-1.8	-3.0	-1.8	-2.0	-2.4	-3.0
Crohns Disease (2012)	3.9	6.4	9.7	-2.6	-1.9	-2.8	-1.9	-2.7	-2.3	-3.1
Hypothyroidism (self reported)	3.9	9.1	14.2	3.5	2.5	3.5	0.1	2.7	3.4	3.8
Multivitamins +/- minerals	3.9	4.9	12.0	-2.1	-1.3	-2.0	-1.5	-3.5	-2.0	-2.5
Commuting to job workplace: Cycle	3.9	4.8	7.3	-2.5	-2.6	-1.7	-0.4	-2.3	-2.2	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.8	4.4	9.4	-2.3	-3.1	-2.2	0.1	-1.9	-1.7	-2.3
Hair/balding pattern: Pattern 3	3.7	5.5	9.4	2.4	1.1	2.6	2.4	2.2	2.1	3.1
Cholesterol lowering medication	3.5	5.1	8.0	-2.8	-1.1	-2.6	-1.6	-2.0	-2.6	-2.5
Mouth/teeth dental problems: Loose teeth	3.4	4.1	8.8	-1.9	-2.2	-1.5	-0.5	-2.6	-1.4	-3.0
Ever taken oral contraceptive pill	3.4	3.7	9.1	1.7	1.4	2.3	0.8	3.0	1.2	2.3
Ever had prostate specific antigen (PSA) test	3.4	3.9	5.5	2.3	2.3	2.3	0.2	1.9	1.6	2.3
Medication: Levothyroxine sodium	3.2	5.5	8.0	2.6	2.8	2.7	-0.4	2.1	2.0	2.8
Miserableness	3.2	5.5	15.4	-1.9	-3.9	-1.2	2.3	-2.7	-1.3	-2.0
Alzheimer’s Disease (in father)	3.1	3.4	11.3	1.6	3.4	1.7	0.3	1.6	0.8	1.9
High blood pressure (siblings)	3.1	4.5	6.5	-2.4	-1.9	-2.4	-1.8	-1.7	-2.0	-2.5
Blood Eosinophil Count	3.0	23.0	44.9	5.0	6.7	3.6	0.3	5.4	2.9	6.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.9	4.4	7.6	-2.0	-2.7	-1.4	0.7	-2.8	-1.3	-2.7
HbA1C	2.8	3.1	5.3	1.7	2.3	2.1	0.1	2.0	1.4	1.8
Lupus	2.7	4.1	9.7	2.8	1.0	2.1	-0.5	1.1	3.1	2.0
Medication: Seretide 50 evohaler	2.7	3.1	10.6	1.8	3.2	1.2	-0.3	0.7	1.0	2.2
Medication: Gliclazide	2.6	2.9	5.7	2.4	0.6	2.1	1.5	0.5	2.2	1.7
Number of operations (self-reported)	2.5	3.7	5.7	-2.4	-1.3	-2.0	-2.0	-1.0	-2.4	-2.0
Medication: Metformin	2.2	3.1	5.6	2.2	-0.1	1.9	2.1	-0.1	2.4	1.7
Had other major operations	2.1	2.6	5.2	-2.3	-1.5	-1.5	-0.6	-1.0	-1.8	-1.9
Taking other prescription medications	2.0	3.1	6.8	2.0	1.9	1.5	0.8	1.8	1.3	2.6
Past tobacco smoking	2.0	3.7	7.2	2.1	1.4	2.7	1.6	0.8	1.9	2.4
Alzheimer’s Disease (including proxy)	1.9	2.7	6.2	2.2	1.7	2.5	0.1	-0.1	1.8	1.4
Ever had hysterectomy (womb removed)	1.9	2.2	6.3	-1.2	-0.4	-1.4	-2.5	-1.4	-1.5	-1.2
Impedance of leg (right)	1.9	9.3	26.2	2.4	5.1	1.6	-0.5	3.8	0.6	4.0
Age when periods started (menarche)	1.9	4.6	13.0	1.7	3.6	1.9	0.4	2.7	0.9	2.0
Vitamin and mineral supplements	1.8	2.4	3.9	1.4	1.0	1.8	1.4	2.0	1.1	1.9
Loud music exposure frequency	1.8	2.0	4.2	-1.1	-2.1	-1.4	-0.3	-1.7	-1.1	-1.4
Hypertension (Self-reported)	1.8	5.0	7.8	-2.6	-1.3	-2.8	-1.6	-1.7	-2.5	-2.6
Relative age of first facial hair	1.7	3.6	7.7	1.5	2.6	1.5	0.3	2.8	0.6	2.4
Allergy	1.7	3.9	5.8	-2.3	-2.4	-2.4	-0.8	-1.5	-1.6	-2.2
Pack years of smoking	1.7	2.5	5.1	-1.8	-0.7	-2.3	-1.4	-1.2	-1.7	-1.6
High blood pressure	1.6	4.5	6.9	-2.5	-1.4	-2.6	-1.3	-1.6	-2.3	-2.5
Impedance of leg (left)	1.6	7.8	23.6	1.9	4.9	1.3	-0.7	3.5	0.2	3.6
Wears glasses or contact lenses	1.6	1.9	4.6	0.9	2.1	0.7	-1.1	1.9	0.4	1.4
Vascular/heart problems diagnosed by doctor	1.6	4.3	7.2	2.6	1.5	2.7	1.2	1.2	2.5	2.2
Supplements: Calcium	1.6	1.7	2.9	1.6	1.6	1.7	1.0	0.3	1.3	1.1
Crohns Disease (2017)	1.5	3.2	5.6	-1.4	-0.7	-2.0	-2.4	-2.0	-1.5	-2.0
Blood Platelet Count	1.5	17.1	27.1	4.6	-1.1	4.4	4.6	1.8	5.1	5.2
BMI	1.5	8.5	18.2	-2.5	-4.3	-2.3	-0.7	-3.6	-1.1	-3.9
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	4.2	1.5	-0.9	1.3	2.0	1.5	2.0	1.4
Loneliness, isolation	1.5	2.1	7.4	0.0	-2.1	0.3	-0.1	-2.7	0.8	-1.4
Number of self-reported non-cancer illnesses	1.5	2.6	7.9	-1.4	1.3	-1.5	-2.8	-0.2	-2.1	-0.6
Mean Putamen Volume	1.4	1.6	3.6	1.3	1.0	1.5	-0.4	1.9	1.2	1.1
Ever used hormone-replacement therapy (HRT)	1.4	1.7	4.2	1.5	-0.4	1.8	1.1	0.1	2.1	1.1
Pack years adult smoking proportion	1.4	2.2	4.4	-1.7	-0.4	-2.1	-1.5	-1.1	-1.5	-1.5
Hayfever, allergic rhinitis or eczema	1.4	3.0	6.0	1.8	2.2	2.4	0.8	1.4	1.0	1.8
Medication: Ramipril	1.4	1.8	3.0	-1.6	0.1	-1.7	-1.3	-1.1	-1.7	-1.1
Medication: Simvastatin	1.4	2.0	4.9	-1.1	1.2	-1.7	-2.2	-0.9	-1.5	-1.1
Illnesses of siblings	1.4	2.0	3.4	1.1	0.8	1.7	1.9	1.6	1.1	1.3
Impedance of arm (right)	1.4	6.7	12.1	2.7	3.5	2.1	1.0	2.9	1.4	3.5
Exposure to tobacco smoke at home	1.4	1.6	4.8	-1.3	-2.2	-1.0	1.6	-0.3	-0.9	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.4	2.7	1.6	0.5	0.9	1.6	-0.4	1.5	1.1
Osteoporosis (self-reported)	1.4	1.7	5.6	1.1	0.7	1.8	2.4	-0.2	0.8	0.8
Smoking status: Current	1.4	2.2	4.8	2.0	0.1	1.2	1.4	1.4	2.2	1.2
Bipolar Disorder (2018)	1.3	2.1	4.0	-1.6	-1.1	-1.7	-0.5	-2.0	-1.3	-1.3
Bipolar Disorder or Schizophrenia	1.3	3.2	7.2	-2.2	-1.2	-2.7	-1.1	-1.2	-2.1	-1.3
Hearing difficulty/problems with background noise	1.3	2.1	4.0	-1.6	-1.4	-1.2	-0.3	-1.8	-1.2	-2.0
Exposure to tobacco smoke outside home	1.3	1.7	5.4	-1.1	-0.4	-0.8	-2.3	-0.9	-1.1	-1.6
Diastolic blood pressure, automated reading	1.3	4.0	7.0	-2.5	0.6	-2.1	-2.6	-0.8	-2.7	-1.8
Ulcerative Colitis (UC)	1.2	2.3	6.2	1.3	2.5	0.4	-1.9	1.3	0.6	1.4
Blood White Count	1.2	8.9	18.1	3.6	-1.8	3.2	3.5	0.8	4.2	2.2
Allergy or Eczema	1.2	3.1	9.4	1.2	3.1	1.9	-0.3	2.1	0.1	1.6
Current tobacco smoking	1.2	1.9	4.9	1.9	-0.0	1.3	1.2	0.9	2.2	0.9
Comparative height size at age 10	1.2	6.6	10.0	2.9	-0.1	2.5	3.2	1.8	3.0	3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.9	-1.6	-0.4	-1.7	-0.3	-0.8	-1.7	-0.8
Financial situation satisfaction	1.2	1.5	4.8	1.4	-0.9	1.0	0.5	-0.1	2.2	1.3
Impedance of whole body	1.2	6.1	15.2	2.1	3.9	1.6	0.4	3.0	0.6	3.3
Average weekly spirits intake	1.1	1.3	4.5	1.7	0.2	1.3	-0.2	-0.0	2.1	0.3
Hearing difficulty/problems: Yes	1.1	1.7	3.6	-1.9	-0.7	-1.0	-0.2	-0.5	-1.8	-1.7
Impedance of arm (left)	1.1	5.1	8.6	2.3	2.9	1.8	1.2	2.6	1.2	2.9
Medication: Ibuprofen	1.1	1.4	7.1	0.5	0.3	0.9	0.3	2.7	0.5	0.9
Suffer from ‘nerves’	1.1	1.8	3.4	1.6	0.2	1.8	1.6	-0.3	1.9	0.6
Long-standing illness, disability or infirmity	1.1	1.7	2.8	1.6	0.8	1.7	1.0	1.0	1.4	1.3
Hearing aid user	1.1	1.2	2.0	-1.2	-1.0	-0.8	0.1	-1.4	-1.1	-1.4
Medication: Blood pressure	1.1	2.1	4.2	-1.9	-0.8	-1.6	-0.8	-1.1	-1.4	-2.0
High cholesterol (Self-reported)	1.1	2.0	3.1	-1.7	0.2	-1.4	-1.1	-1.5	-1.8	-1.5
Fasting Glucose	1.0	1.1	2.0	0.9	0.1	1.1	-0.4	1.4	1.4	1.4
Triglycerides	1.0	1.7	3.9	-1.6	-0.2	-2.0	-1.4	0.2	-1.5	-1.0
Respiratory disease	1.0	2.3	7.9	0.8	2.8	0.2	-1.5	1.8	0.1	1.5
Body mass index (BMI)	1.0	4.3	8.8	-2.3	-1.6	-2.5	-1.7	-1.6	-1.5	-3.0
Depression (self-reported)	1.0	1.2	3.7	-0.8	-1.9	-0.5	-0.3	-1.5	-0.7	-1.0
Lung cancer (father)	1.0	1.1	3.3	-1.2	0.3	-1.0	-1.0	0.1	-1.8	-1.0
Medication for cholesterol	1.0	1.5	2.8	1.7	0.8	1.5	0.9	0.9	1.3	1.3
Fractured/broken bones in last 5 years	1.0	1.3	2.2	1.5	-0.0	1.2	1.3	-0.6	1.5	0.8
Schizophrenia vs Biploar Disorder	0.9	1.2	3.6	0.2	1.3	-0.1	-1.5	1.9	-0.1	0.8
Body Mass Index (BMI) (2010)	0.9	1.2	3.6	0.4	-1.9	0.7	1.3	-1.2	1.0	-0.0
Coronary Artery Disease (CAD)	0.9	1.1	2.3	-0.9	-0.3	-1.5	-1.5	-0.8	-0.9	-1.0
Cardiovascular Disease	0.9	2.8	5.2	-2.1	-1.2	-2.3	-0.8	-1.3	-2.0	-1.4
Hand grip strength (left)	0.9	2.4	4.6	-1.4	0.9	-1.7	-2.1	1.0	-2.1	-0.7
Maternal smoking around birth	0.9	1.3	3.5	-0.9	-1.6	-0.5	-0.2	-1.3	-0.5	-1.9
Stomach or abdominal pain in last month	0.9	1.1	3.2	-0.1	-1.6	1.0	-0.3	-1.8	0.4	-0.9
Number of incorrect matches in round	0.9	1.5	3.6	-0.5	-1.9	0.0	1.6	-0.5	-0.0	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	4.3	0.9	-0.2	1.0	0.6	2.1	0.9	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.6	-1.3	-0.8	-1.2	0.5	-1.2	-0.8	-1.6
Pulse rate, automated reading	0.9	2.9	6.8	2.1	1.6	2.6	1.0	0.6	2.0	1.1
Overall health rating	0.9	2.0	3.4	1.9	0.7	1.6	0.7	1.3	1.8	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.8	-1.2	-0.8	-0.6	-1.2	-1.4	-0.7	-1.1
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	4.1	-1.2	0.5	-1.1	-0.6	-0.2	-2.0	-0.4
Average weekly red wine intake	0.9	1.3	2.3	-1.4	-1.5	-0.7	0.3	-1.1	-1.2	-1.3
Leg fat percentage (left)	0.9	3.2	6.7	-1.6	1.7	-2.2	-2.6	0.1	-1.8	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	3.9	1.6	0.1	1.1	0.0	0.1	2.0	0.6
Depressed Affect (Nagel 2018)	0.8	1.7	5.1	0.0	-2.2	0.6	1.0	-2.0	0.5	-1.0
Schizophrenia (2018)	0.8	1.6	4.5	-1.5	-0.6	-2.1	-1.0	-0.0	-1.6	-0.6
Prostate Cancer	0.8	1.1	3.3	0.6	0.6	0.5	1.8	1.1	0.1	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.5	0.8	-1.3	0.4	1.6	-0.9	1.3	-0.1
Financial difficulties in last 2 years	0.8	1.1	3.6	1.3	-0.4	1.0	0.3	-0.9	1.9	0.7
Neuroticism score	0.8	1.6	3.1	-1.2	-1.6	-0.8	0.8	-1.8	-0.8	-1.4
Time employed in main current job	0.8	0.9	1.8	0.7	-0.7	0.9	1.0	1.3	0.9	1.0
Peak expiratory flow (PEF)	0.8	1.8	6.6	-0.9	-2.6	-1.0	-1.1	-1.3	-0.4	-1.2
Birth weight	0.8	1.7	3.9	-1.6	-1.0	-1.8	-0.8	0.0	-2.0	-0.7
Leg fat percentage (right)	0.8	2.9	6.5	-1.3	1.9	-2.1	-2.6	0.4	-1.6	-1.1
Chest pain or discomfort	0.8	1.1	2.4	-0.3	1.1	-1.1	-1.5	1.2	-1.2	0.3
Risk taking	0.8	1.2	4.4	-1.0	0.5	-0.6	-2.1	0.8	-1.3	-0.3
Intelligence (Savage-Jansen 2018)	0.7	2.0	4.0	-2.0	-0.6	-1.5	-0.8	-0.1	-1.9	-1.7
Severe depression (siblings)	0.7	0.8	3.0	-1.0	-1.7	-0.9	0.6	-0.4	-0.7	-0.3
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.1	-0.6	1.4	-0.2	-1.4	0.1	-1.1	-0.7
Number of live births	0.7	1.0	3.5	-0.5	-1.7	0.1	1.9	-0.7	-0.2	-0.2
Commuting to job workplace: Car/motor vehicle	0.7	0.9	4.2	-0.5	-0.9	-0.6	0.1	-2.0	-0.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.0	1.6	0.2	1.5	0.4	1.2	1.7	1.1
Osteoarthritis (self-reported)	0.7	0.9	1.7	1.3	0.4	1.2	0.5	0.3	1.0	1.2
Mother’s age at death	0.7	0.9	1.8	1.0	-0.4	1.1	1.3	-1.2	0.9	-0.2
Commuting to job workplace: Public transport	0.7	0.9	2.0	0.8	0.6	0.6	-1.4	1.2	0.7	0.8
Ever smoked	0.7	1.3	2.6	-1.0	-1.2	-1.6	-1.0	-0.3	-0.8	-1.5
Pain experienced in last month	0.7	1.2	3.3	1.0	1.8	1.2	0.1	0.7	0.6	1.4
Alcohol drinker status: Previous	0.7	0.8	2.5	-0.8	0.3	-0.7	-1.6	-0.1	-0.8	-1.0
Irritable Bowel Disease (IBD)	0.6	1.5	7.0	0.1	1.5	-0.9	-2.6	-0.1	-0.5	0.0
Ovarian Cancer	0.6	0.8	1.1	-1.1	-0.9	-1.0	-0.5	-0.9	-1.1	-0.7
Schizophrenia (2014)	0.6	1.3	4.5	-1.3	-0.4	-2.1	-0.8	-0.1	-1.4	-0.7
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.5	-0.8	-0.4	-0.8	-1.2	-0.5	-0.9	-0.8
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.6	1.2	0.3	1.2	1.6	0.3	0.9	1.4
Neuroticism	0.6	1.4	3.6	-1.1	-1.3	-0.8	0.4	-1.9	-0.8	-1.4
Angina	0.6	0.8	1.6	-0.5	1.2	-1.1	-0.7	0.5	-1.3	0.1
Chronic bronchitis/emphysema (father)	0.6	0.7	2.1	-0.5	-1.5	-0.0	0.4	-1.1	-0.2	-1.0
Asthma	0.6	1.1	4.7	0.4	2.2	0.1	-0.6	1.2	-0.2	1.1
Hair/balding pattern: Pattern 4	0.6	1.5	3.6	-0.6	-1.7	-0.5	0.4	-1.7	0.1	-1.9
Headache pain in last month	0.6	1.0	5.1	-0.8	-2.3	-0.7	0.5	-0.0	-0.3	-0.8
Glaucoma (self-reported)	0.6	0.7	1.4	1.1	0.2	0.9	0.1	0.6	1.2	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.9	-1.0	-0.3	-0.6	0.2	-0.8	-1.4	-0.8
Shortness of breath walking on level ground	0.6	0.7	1.6	1.3	0.4	1.1	0.3	0.1	1.2	0.7
Medication: Omeprazole	0.6	0.7	1.8	-1.0	0.4	-0.9	-0.2	-0.9	-1.4	-0.6
Mood swings	0.6	1.1	4.0	-0.6	-2.0	-0.4	0.7	-1.2	-0.1	-1.1
Mineral and other dietary supplements	0.6	0.8	2.6	0.5	-1.6	0.3	1.3	-0.8	0.7	0.5
Age started oral contraceptive pill	0.6	0.7	1.8	0.3	1.4	1.2	-1.0	0.9	0.0	0.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	0.5	-0.5	1.0	-0.5	-1.3	0.8	-0.1
Major Depression (MDD)	0.5	0.7	1.5	-0.8	-0.8	-1.1	-0.0	-0.4	-0.8	-1.2
Reaction Time	0.5	0.9	2.2	0.2	-1.1	0.2	0.9	-1.5	0.5	-1.2
Age at First Birth	0.5	0.7	1.6	-0.8	0.6	-0.2	0.2	-0.9	-1.3	-1.3
Ulcerative Colitis	0.5	0.8	2.9	0.4	1.7	-0.2	-1.3	0.6	-0.2	0.6
Number of treatments/medications taken	0.5	0.9	2.4	0.9	1.6	0.5	0.1	0.8	0.3	1.5
Supplements: Zinc	0.5	0.5	1.5	-0.2	1.2	-1.1	-0.3	-0.1	-0.8	0.5
Diabetes (father)	0.5	0.6	1.9	-0.8	-1.4	-1.0	-0.0	0.2	-0.5	-0.4
Fed-up feelings	0.5	1.0	2.1	0.7	-1.5	0.7	1.3	-1.0	1.1	0.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.3	-0.8	0.2	-0.5	-1.5	-0.4	-0.7	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	2.8	0.8	-1.7	0.6	0.1	-0.1	1.4	1.1
Serious illness, injury or assault to yourself	0.5	0.7	3.2	0.4	0.6	0.1	-0.5	1.8	0.7	0.2
High blood pressure (mother)	0.5	0.8	1.7	0.9	-0.5	1.0	1.3	-0.5	1.1	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.8	0.1	-1.7	0.4	0.1	-1.3	0.5	-0.6
Diabetes (self-reported)	0.5	0.8	1.5	1.1	-0.2	1.2	0.9	0.3	0.9	1.1
Mouth/teeth dental problems: Dentures	0.5	0.9	4.3	-0.1	2.1	-0.8	-0.8	0.2	-0.3	0.4
Standing height	0.5	5.0	9.1	2.7	0.8	3.0	2.0	1.5	2.4	2.4
Length of working week for main job	0.5	0.5	1.3	-0.9	-0.1	-0.8	-0.5	-0.7	-0.7	-1.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.8	0.7	0.1	1.3	1.4	0.6	1.1	0.9
Comparative body size at age 10	0.5	1.5	4.2	0.4	-2.0	0.3	1.1	-1.3	1.6	-0.8
Angina (self-reported)	0.5	0.6	2.2	-0.1	1.5	-0.8	-0.6	0.6	-0.9	0.4
Leg pain on walking	0.5	0.7	1.8	1.0	0.4	0.4	0.2	1.3	0.6	1.1
Supplements: Vitamin C	0.5	0.6	1.8	-0.4	0.6	-0.9	-1.3	0.4	-0.6	-0.3
Leg fat-free mass (right)	0.5	2.5	8.7	-0.7	-3.0	-0.2	0.6	-2.0	0.5	-2.0
Diabetes diagnosed by doctor	0.5	0.8	1.4	1.1	-0.1	1.1	1.2	0.1	0.9	0.9
Breast cancer (self-reported)	0.5	0.6	1.9	0.5	0.8	0.5	-0.2	1.0	0.3	1.4
Asthma (self-reported)	0.5	1.1	4.9	0.4	2.2	0.0	-0.7	1.0	-0.3	1.0
Leg predicted mass (right)	0.5	2.7	9.6	-0.7	-3.1	-0.2	0.5	-2.0	0.5	-2.0
Arm fat mass (left)	0.5	2.1	5.0	-1.6	-1.0	-1.9	-0.8	-1.0	-1.0	-2.2
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.2	-1.0	0.4	-0.8	-1.0	0.2	-1.1	-0.7
Illnesses of father: High blood pressure	0.5	0.6	1.5	-0.2	-1.2	0.3	1.0	-0.7	0.5	-0.8
Alcohol drinker status: Never	0.5	0.6	1.7	0.6	0.6	0.8	1.3	-0.4	0.9	0.2
Unable to work because of sickness or disability	0.5	0.7	1.5	-0.7	-0.2	-0.9	0.8	-1.2	-0.9	-0.6
Leg fat mass (left)	0.5	1.8	3.3	-1.4	0.2	-1.8	-1.8	-0.4	-1.1	-1.8
Blood Red Count	0.4	3.9	8.2	2.4	-0.4	2.8	0.8	0.2	2.9	2.2
Chronotype (morning person)	0.4	0.8	1.3	-1.1	-0.4	-1.2	-0.7	-0.8	-0.9	-1.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.5	0.3	-1.2	0.1	1.0	-1.1	0.6	-0.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.7	0.8	1.3	1.2	0.2	0.2	0.4	0.4
Systolic blood pressure, automated reading	0.4	1.2	2.7	-1.3	1.0	-1.6	-0.6	-0.2	-1.6	-0.4
Leg fat-free mass (left)	0.4	2.2	7.7	-0.5	-2.8	-0.1	0.6	-1.8	0.6	-1.8
Leg predicted mass (left)	0.4	2.2	7.7	-0.5	-2.8	-0.2	0.5	-1.8	0.6	-1.8
Pain all over the body in last month	0.4	0.4	1.1	-0.5	1.0	-0.1	-0.5	0.8	-0.6	-0.4
Worrier / anxious feelings	0.4	0.8	2.0	-0.2	-1.3	-0.4	1.3	-1.4	-0.0	-0.4
Pulse rate	0.4	0.7	2.1	-0.8	-0.7	-0.3	-0.6	-1.0	-0.4	-1.4
Happiness	0.4	0.5	2.1	0.2	1.1	-0.3	-0.5	0.3	-0.1	1.4
Noisy workplace	0.4	0.5	1.3	-1.1	0.3	-0.9	-0.0	0.2	-1.1	-0.7
Medication: Lansoprazole	0.4	0.5	1.7	0.2	0.8	-0.3	0.6	1.3	-0.1	0.5
Prospective memory result	0.4	0.6	1.5	-0.4	-0.2	-1.1	0.2	-1.2	-0.7	-0.7
Illnesses of mother	0.4	0.5	2.4	0.1	0.5	0.3	-0.1	1.6	0.3	0.7
Pulse wave Arterial Stiffness index	0.4	0.4	0.8	-0.5	0.9	-0.8	-0.7	0.4	-0.9	-0.2
Arm fat mass (right)	0.4	1.8	4.4	-1.4	-1.0	-1.6	-0.8	-1.2	-0.8	-2.1
Blood clot in the leg (DVT)	0.4	0.5	1.7	1.0	-0.1	0.6	-0.2	-0.3	1.3	0.0
Body fat percentage	0.4	1.5	2.9	-1.0	1.1	-1.7	-1.7	0.1	-1.1	-1.2
Age at first live birth	0.4	0.7	1.4	-0.7	0.8	-0.7	-1.2	-0.6	-0.8	-0.8
Pulse wave peak to peak time	0.4	0.5	0.8	0.5	-0.9	0.8	0.7	-0.5	0.9	0.1
Health satisfaction	0.4	0.5	0.8	-0.6	-0.6	-0.9	-0.6	-0.8	-0.6	-0.7
Neck or shoulder pain in last month	0.4	0.6	3.0	0.3	-1.7	0.6	0.4	0.4	0.6	-0.5
Medication: Allopurinol	0.4	0.6	2.2	0.0	-1.0	0.4	0.6	-1.5	0.3	-0.4
Mean time to correctly identify matches	0.4	0.8	2.1	-0.4	-1.1	-0.5	0.7	-1.1	-0.2	-1.4
Leg fat mass (right)	0.4	1.6	3.2	-1.2	0.3	-1.8	-1.8	-0.3	-0.9	-1.6
Illnesses of siblings: Diabetes	0.4	0.5	2.3	0.0	0.5	-0.5	-0.7	-1.5	-0.2	-0.2
Arm fat percentage (left)	0.4	1.5	3.1	-1.3	-0.1	-1.7	-1.1	-0.6	-1.0	-1.8
Eye problems/disorders: Cataract	0.4	0.4	2.2	-0.4	-0.0	-0.5	-1.5	-0.1	-0.4	-0.5
Back pain experienced in last month	0.4	0.5	1.5	0.8	0.0	-0.0	1.2	0.8	0.8	0.7
Guilty feelings	0.4	0.5	1.8	0.5	-0.1	0.8	1.3	0.3	0.7	0.7
Depression (Nagel 2018)	0.3	0.4	1.1	0.6	-0.4	0.5	1.0	-1.0	0.6	-0.0
Neuroticism (Nagel 2018)	0.3	0.8	2.7	-0.3	-1.2	0.3	0.7	-1.6	0.2	-0.9
Breast Cancer	0.3	0.8	1.9	1.2	-0.4	0.7	0.6	0.5	1.4	1.0
Height	0.3	5.7	11.5	2.9	2.1	2.4	0.5	2.6	1.7	3.4
Lung FEV1/FVC ratio	0.3	1.4	5.3	0.2	-2.3	0.2	0.7	-0.7	1.5	-1.0
Sensitivity / hurt feelings	0.3	0.5	1.6	-0.7	-0.6	-0.8	0.2	-1.3	-0.3	-0.7
Hand grip strength (right)	0.3	0.9	1.6	-1.1	-0.5	-1.2	-1.3	-0.1	-1.1	-0.9
Townsend deprivation index at recruitment	0.3	0.4	1.4	-0.3	-1.2	-1.0	-0.2	-0.1	0.1	-0.6
Waist circumference	0.3	1.0	1.5	-0.9	0.6	-1.2	-1.2	-0.7	-0.9	-1.2
Arm fat percentage (right)	0.3	1.3	2.7	-1.2	0.2	-1.6	-1.1	-0.4	-0.9	-1.6
Medication: Cholesterol lowering	0.3	0.5	1.4	-0.3	0.6	-0.9	-1.2	-0.2	-0.8	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.5	0.7	-1.6	0.7	0.2	0.3	1.1	1.0
Tense / ‘highly strung’	0.3	0.5	1.2	-0.8	-0.1	-1.1	-0.5	-0.3	-0.8	-0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.8	-0.8	-0.8	0.2	0.3	-0.9	-0.8	-0.8
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	-0.7	-0.4	-0.4	-0.6	0.4	-1.0	-0.8
Medication: Paracetamol	0.3	0.6	0.8	0.7	-0.9	0.6	0.9	0.8	0.8	0.6
Gout (self-reported)	0.3	0.4	1.3	0.1	-0.7	0.4	0.3	-1.2	0.4	-0.7
Arm fat-free mass (right)	0.3	1.4	3.8	-0.9	-1.9	-0.5	0.0	-1.5	-0.0	-1.7
Worry too long after embarrassment	0.3	0.4	1.2	-0.7	-1.1	-0.2	0.4	-0.8	-0.4	-0.5
Wheeze or whistling in the chest in last year	0.3	0.6	2.2	0.8	1.5	0.5	0.2	0.8	0.1	0.8
Emphysema/chronic bronchitis	0.3	0.3	0.9	-0.1	0.9	0.1	-0.9	-0.5	0.1	-0.5
Medication: Blood pressure	0.3	0.6	1.1	-0.7	-0.3	-1.0	-0.8	-0.7	-0.9	-0.9
Migraine (self-reported)	0.3	0.3	0.8	0.4	-0.1	0.3	0.8	0.9	0.5	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.9	-0.3	0.9	-0.2	-1.0	-0.3	-0.7	-0.3
Whole body fat mass	0.3	1.2	2.5	-1.1	-0.1	-1.5	-1.1	-0.6	-0.8	-1.6
Arm predicted mass (right)	0.3	1.5	4.6	-0.8	-2.1	-0.4	0.3	-1.5	0.1	-1.7
Age at last live birth	0.3	0.4	2.5	0.1	1.6	-0.2	-0.4	0.3	-0.3	0.5
Illnesses of father: Heart disease	0.3	0.4	1.0	-0.7	-0.2	-0.9	-0.2	-1.0	-0.7	-0.3
Whole body fat-free mass	0.3	1.7	6.2	-0.7	-2.5	-0.2	0.5	-1.4	0.3	-1.6
Friendships satisfaction	0.3	0.4	0.8	0.5	0.6	0.5	-0.8	-0.9	0.5	0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.5	0.7	0.1	1.2	0.6	-0.2	0.8	0.7
Illnesses of father: None of the above (group 1)	0.3	0.4	0.9	0.6	0.8	0.3	-0.9	0.6	0.4	0.6
Whole body water mass	0.3	1.6	6.1	-0.7	-2.5	-0.2	0.6	-1.4	0.4	-1.6
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.1	0.3	-1.0	0.0	0.2	-1.0	0.5	-0.5
Eye problems/disorders: Glaucoma	0.3	0.4	0.8	0.9	-0.3	0.3	0.5	0.2	0.9	0.9
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.6	-0.5	-0.6	-0.8	0.3	-0.6	-0.5	-0.8
Medication: Atorvastatin	0.3	0.4	1.4	-0.6	-0.6	-0.4	1.2	-0.3	-0.5	-0.1
Basal metabolic rate	0.3	1.5	4.8	-0.8	-2.2	-0.4	0.3	-1.4	0.2	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	-0.5	0.9	-0.5	-0.3	-0.6	-1.0	-0.2
Heart disease (siblings)	0.3	0.4	1.5	0.4	1.2	0.2	-0.1	0.7	0.0	0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.9	-0.9	0.1	-0.8	-0.3	0.7	-1.0	-0.6
Neuroticism (2016)	0.2	0.3	0.7	-0.6	-0.7	-0.6	0.5	-0.3	0.2	-0.9
Rheumatoid Arthritis	0.2	0.3	0.9	-0.3	-0.5	-0.9	-0.1	-0.8	-0.1	-0.2
Lung FVC	0.2	0.8	2.3	-0.7	0.8	-0.6	-1.5	1.0	-0.8	-0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.8	-0.2	-0.9	-0.5	0.6	-0.2	-0.1	0.5
Medication for hormone replacement therapy	0.2	0.3	1.5	0.2	-1.2	0.0	-0.1	-0.1	0.6	-0.1
Trunk fat percentage	0.2	0.9	1.6	-0.7	0.7	-1.3	-1.3	-0.1	-0.7	-1.2
Relative age voice broke	0.2	0.3	0.6	-0.7	-0.0	0.1	-0.7	0.6	-0.7	-0.1
Qualifications: CSEs or equivalent	0.2	0.2	0.9	0.3	1.0	0.1	0.1	0.1	0.3	0.6
Supplements: Glucosamine	0.2	0.3	0.8	-0.1	0.9	-0.0	-0.6	0.8	-0.3	-0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.7	0.3	-0.8	-0.2	-0.8	0.2	0.5	-0.2
Medication: Atenolol	0.2	0.2	0.5	0.6	-0.3	0.2	0.6	-0.2	0.7	0.6
Nervous feelings	0.2	0.3	1.4	-0.2	-0.7	0.1	1.2	-0.5	0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.4	0.3	-1.2	-0.3	-0.4	0.4	0.6	0.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	0.5	0.4	0.9	-0.5	-0.5	0.2	0.4
Qualifications: None of the above	0.2	0.3	0.7	0.8	-0.8	-0.4	0.5	0.0	0.8	-0.0
Heart attack	0.2	0.2	0.9	0.3	1.0	-0.6	-0.1	0.1	-0.1	0.6
Fluid intelligence score	0.2	0.4	0.9	-0.7	0.7	-0.1	-0.4	0.8	-0.9	-0.2
Weight	0.2	0.9	2.7	-0.9	-1.1	-0.9	-0.6	-0.8	-0.2	-1.6
Trunk fat-free mass	0.2	1.1	4.4	-0.6	-2.1	-0.1	0.6	-1.0	0.3	-1.2
Father’s age at death	0.2	0.3	0.7	0.2	-0.3	0.6	0.8	-0.6	0.4	-0.4
Falls in the last year	0.2	0.2	0.6	-0.2	0.8	0.0	-0.7	0.2	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	3.1	-0.2	-1.8	-0.3	-0.7	0.2	0.2	0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.7	-0.1	-0.8	0.7	0.1	-0.8	0.3	-0.8
Trunk predicted mass	0.2	1.0	4.1	-0.6	-2.0	-0.0	0.6	-0.9	0.3	-1.2
Breastfed as a baby	0.2	0.2	0.5	0.4	-0.3	0.7	-0.6	0.1	0.5	-0.2
Medication: Amlodipine	0.2	0.2	1.2	0.2	1.1	-0.4	-0.0	-0.4	-0.3	0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.7	0.2	0.8	0.4	0.1	0.8	-0.1	0.5
Chronic bronchitis/emphysema (mother)	0.2	0.2	1.1	-0.1	-0.2	-0.1	-1.1	-0.3	-0.6	0.1
Forced vital capacity (FVC), Best measure	0.2	0.8	1.5	0.9	-1.1	0.8	0.2	0.5	1.0	1.2
Eye problems/disorders: None of the above	0.2	0.2	0.6	-0.4	-0.1	0.1	0.8	-0.5	-0.4	-0.6
Medication for pain relief, constipation, heartburn	0.2	0.4	1.5	-0.5	0.6	-0.4	-0.4	-1.2	-0.3	-0.7
Heart disease (mother)	0.2	0.2	0.6	0.2	-0.8	-0.5	0.1	0.3	0.1	0.7
Family relationship satisfaction	0.2	0.2	0.7	-0.5	-0.3	-0.3	-0.9	-0.4	-0.2	-0.3
Medication: Aspirin	0.2	0.2	0.5	0.6	0.4	0.3	0.3	0.7	0.5	0.3
Knee pain experienced in last month	0.2	0.4	0.9	0.8	-0.5	0.6	0.3	-0.1	1.0	0.5
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.8	-0.2	0.2	-0.5	-0.9	-0.4	-0.3	-0.6
Ever had bowel cancer screening	0.2	0.2	1.4	-0.0	1.2	0.1	-0.5	0.2	-0.2	-0.0
Medication: Aspirin	0.2	0.3	0.7	0.5	0.8	0.4	-0.2	0.9	0.2	0.4
Average weekly champagne plus white wine intake	0.2	0.3	0.5	0.7	0.6	0.5	-0.0	-0.2	0.5	0.7
Medication: Bendroflumethiazide	0.2	0.4	1.0	-0.5	0.7	-0.3	-0.4	-0.0	-0.7	-1.0
Medication: Paracetamol	0.2	0.3	0.6	0.5	-0.8	0.4	0.7	0.4	0.7	0.2
Medication: Lisinopril	0.2	0.2	0.7	0.2	0.9	0.3	-0.5	0.4	0.1	-0.3
Arm fat-free mass (left)	0.2	0.9	2.0	-0.7	-1.4	-0.5	0.1	-1.2	-0.1	-1.4
Irritability	0.2	0.3	1.0	-0.6	-0.1	-1.0	0.3	-0.5	-0.4	-0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.8	0.2	0.9	-0.7	-0.3	0.0	-0.1	0.5
Arm predicted mass (left)	0.2	1.0	3.0	-0.7	-1.7	-0.3	-0.0	-1.2	0.1	-1.4
Worry (Nagel 2018)	0.1	0.2	0.8	0.1	-0.1	0.0	0.0	-0.9	0.3	-0.8
LDL Cholesterol	0.1	0.1	0.2	-0.4	0.2	-0.2	-0.5	-0.3	-0.3	-0.4
Heel T-Score	0.1	1.1	3.1	0.8	-1.5	0.9	-0.1	0.4	1.8	0.9
Waist Hip Ratio (WHR)	0.1	0.6	2.6	-0.1	1.6	-0.2	0.0	-0.6	-0.8	0.5
Systolic Blood Pressure	0.1	0.3	0.8	-0.4	0.9	-0.7	0.2	-0.2	-0.7	-0.2
Smoking Status	0.1	0.3	1.4	0.1	-0.2	-0.9	-0.2	1.2	0.1	-0.1
Tanning	0.1	1.4	4.3	-0.7	-2.1	-0.8	0.8	-1.4	-0.1	-1.3
Medication: Co-codamol	0.1	0.1	0.3	-0.4	-0.1	0.1	0.3	-0.1	-0.6	-0.2
Diabetes (mother)	0.1	0.1	0.2	-0.3	0.3	-0.4	0.2	-0.2	-0.4	-0.0
Average weekly fortified wine intake	0.1	0.1	0.7	-0.0	0.8	0.2	-0.2	-0.3	-0.1	-0.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.4	-0.1	0.2	-0.0	0.4	0.4	0.2
Sitting height	0.1	0.5	1.1	0.5	0.3	0.9	0.6	1.1	0.2	0.8
Trunk fat mass	0.1	0.6	1.6	-0.6	0.1	-1.1	-1.0	-0.3	-0.4	-1.2
Alcohol usually taken with meals	0.1	0.1	0.8	-0.1	-0.9	0.4	0.2	-0.2	-0.0	0.0
Hair/balding pattern: Pattern 2	0.1	0.2	0.6	-0.0	-0.4	0.3	-0.4	-0.4	-0.2	-0.8
Had menopause	0.1	0.1	0.4	0.2	0.0	-0.2	-0.7	-0.3	0.3	0.2
Forced vital capacity (FVC)	0.1	0.4	0.9	0.4	-0.9	0.3	-0.5	0.7	0.5	0.9
Mouth/teeth dental problems	0.1	0.2	0.9	0.2	-0.3	0.2	1.0	-0.5	0.3	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.5	0.4	0.0	0.1	-0.5	-0.5	0.7	0.0
Birth weight of first child	0.1	0.2	0.5	-0.3	-0.0	0.4	0.7	0.7	-0.4	0.3
Pulse wave reflection index	0.1	0.2	0.5	0.1	-0.3	-0.6	0.7	-0.0	0.3	-0.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.6	-0.2	-0.0	-0.4	-0.3	-0.8	-0.3	0.0
Number of full brothers	0.1	0.2	0.5	0.4	-0.2	-0.4	-0.0	0.7	0.2	0.5
Number of children fathered	0.1	0.1	0.2	0.4	-0.1	0.5	0.3	0.4	0.5	0.3
Qualifications: College or University degree	0.1	0.3	0.8	-0.7	-0.5	0.3	0.9	-0.1	-0.8	-0.4
Alcohol intake frequency.	0.1	0.2	1.4	0.2	1.2	0.1	0.3	0.2	-0.1	0.3
Number of full sisters	0.1	0.1	0.3	0.0	0.5	-0.5	-0.5	0.3	-0.3	0.1
Had major operations	0.1	0.2	0.6	0.3	0.8	-0.0	-0.0	0.0	-0.2	0.6
Qualifications: nursing, teaching	0.1	0.2	0.4	-0.4	0.5	0.5	0.7	-0.3	-0.5	-0.1
Commuting to job workplace: Walk	0.1	0.1	0.4	0.5	-0.1	0.4	0.3	0.2	0.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.7	-0.1	-0.8	0.0	0.0	0.8	0.3	0.1
Average weekly beer plus cider intake	0.1	0.2	0.4	-0.5	-0.6	-0.4	0.6	-0.1	-0.1	-0.1
Ever depressed for a whole week	0.1	0.1	0.8	0.1	0.2	0.1	0.1	-0.9	-0.3	-0.2
Myopia	0.1	0.2	0.4	-0.5	-0.6	-0.3	0.2	-0.1	-0.5	0.1
HDL Cholesterol	0.0	0.1	0.1	0.1	-0.4	0.2	-0.3	0.2	0.2	0.1
Hair Pigment	0.0	0.4	1.5	0.2	-0.9	1.2	0.7	-0.3	0.0	0.2
Hip circumference	0.0	0.2	0.7	-0.1	0.4	-0.4	-0.4	0.1	0.0	-0.8
Alcohol intake versus 10 years previously	0.0	0.1	0.2	0.4	-0.3	0.0	-0.1	0.1	0.2	0.4

Hub : Genes

ZC3HAV1

Models

Trait associations