Hub : Genes

TTC26

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.059	0.0260	0.01300	0.033	0.017	0.016	0.023	0.031	6.7e-05	3.1e-03	3.9e-03	7.3e-04	1.0e-04
2	GTEx	Testis	0.215	0.0820	0.00320	0.009	NA	0.017	NA	0.044	1.2e-01	NA	5.5e-02	NA	4.8e-03
3	YFS	Blood	0.122	0.0228	0.00000	0.053	0.088	0.088	0.094	0.085	5.5e-17	3.8e-27	2.6e-27	5.2e-29	2.1e-26
4	TCGA	Stomach Adenocarcinoma	0.089	0.0370	0.00011	0.041	0.040	0.024	NA	0.026	5.8e-04	6.6e-04	6.8e-03	NA	5.4e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.9	1.5	3.5	-1.1	1.1	0.1	1.9
Bipolar Disorder or Schizophrenia	0.2	0.5	1.1	-0.3	1.0	0.3	0.8
Depressed Affect (Nagel 2018)	2.1	4.4	8.9	-2.6	3.0	-1.5	-0.1
Depression (Nagel 2018)	1.5	2.2	6.1	-1.4	2.5	0.3	0.9
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.3	-0.4	-0.1	0.2	-1.1
Neuroticism (Nagel 2018)	1.9	4.5	10.3	-2.6	3.2	-1.0	0.3
Schizophrenia (2018)	0.1	0.2	0.2	0.5	0.5	0.3	-0.4
Schizophrenia vs Biploar Disorder	1.2	1.6	2.8	1.7	-1.2	-0.7	-1.3
Worry (Nagel 2018)	1.0	2.2	5.0	-1.7	2.2	-0.7	-0.5
Alzheimer’s Disease (in mother)	1.0	1.1	3.4	-0.6	-0.8	-1.8	0.3
Alzheimer’s Disease (in father)	1.2	1.3	2.0	1.4	-1.0	1.1	1.0
Alzheimer’s Disease (including proxy)	0.8	1.1	2.3	0.5	-1.5	-1.1	0.9
Crohns Disease (2017)	0.8	1.8	6.3	-0.6	-0.6	-2.5	-0.6
Irritable Bowel Disease (IBD)	1.0	2.4	4.5	0.8	-2.0	-2.1	-0.4
Ulcerative Colitis (UC)	1.2	2.2	5.2	1.4	-2.3	-1.2	-0.4
Major Depression (MDD)	0.8	1.0	3.3	0.5	0.1	-0.5	-1.8
Reaction Time	0.8	1.6	3.8	-1.9	1.6	-0.2	-0.3
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.1	0.2	-0.5	-0.2	-1.4
Breast Cancer	0.1	0.1	0.4	0.2	0.6	-0.3	0.1
Ovarian Cancer	0.4	0.5	1.0	-1.0	0.4	-0.1	0.8
Prostate Cancer	1.2	1.7	2.6	1.6	0.9	1.3	1.4
Age at First Birth	0.1	0.2	0.6	0.0	0.3	0.8	-0.1
Bipolar Disorder (2011)	1.5	1.5	3.5	-1.3	0.9	-1.9	0.0
Body Mass Index (BMI) (2010)	2.0	2.7	5.8	-1.4	2.4	-1.2	1.2
Coronary Artery Disease (CAD)	0.4	0.4	1.2	0.2	-0.3	-1.1	-0.6
Crohns Disease (2012)	0.7	1.2	3.2	-0.5	0.1	-1.8	-1.2
Mean Putamen Volume	2.7	3.1	8.1	0.5	-1.0	-1.7	-2.9
Fasting Glucose	1.2	1.4	2.6	1.5	-0.4	-1.6	-0.9
HbA1C	1.4	1.5	3.4	1.9	-0.7	-1.2	-0.7
HDL Cholesterol	0.2	0.3	0.5	0.3	0.7	-0.0	-0.7
LDL Cholesterol	0.7	1.1	2.5	1.0	-0.6	1.6	0.6
Lupus	2.3	3.5	10.3	-1.3	-1.1	-3.2	-0.9
Neuroticism (2016)	1.3	1.9	4.1	-1.8	2.0	-0.1	-0.6
Primary Biliary Cirrhosis	0.5	0.7	1.8	0.8	-1.4	-0.4	-0.1
Rheumatoid Arthritis	0.8	1.1	2.5	0.2	0.7	1.2	1.6
Schizophrenia (2014)	0.4	0.9	1.5	0.8	1.2	1.1	0.4
Triglycerides	0.3	0.6	1.7	0.3	-1.3	-0.5	-0.4
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.8	0.1	-0.9	-1.7	-0.7
Ulcerative Colitis	0.8	1.2	2.4	1.5	-1.5	0.1	0.1
Blood Eosinophil Count	1.8	13.6	32.1	5.7	-4.3	1.8	0.8
Blood Platelet Count	0.3	3.5	9.4	1.1	1.7	0.7	3.1
Blood Red Count	0.7	6.5	11.9	-3.2	-2.0	-3.5	0.2
Blood White Count	0.1	0.7	2.7	-0.2	1.6	0.3	0.1
Heel T-Score	0.4	3.3	10.2	-3.2	0.7	-1.6	-0.2
BMI	2.7	15.8	48.0	-6.9	3.0	-2.4	-0.3
Height	0.3	4.9	12.2	3.5	-1.8	1.8	1.0
Waist Hip Ratio (WHR)	0.3	1.5	3.6	0.8	-1.0	0.9	1.9
Systolic Blood Pressure	0.2	0.9	1.7	1.1	0.1	1.3	0.8
Smoking Status	0.6	1.5	4.3	-1.0	-0.9	-0.3	-2.1
Allergy or Eczema	1.0	2.7	5.8	2.1	-2.4	-0.1	-0.7
Cardiovascular Disease	0.2	0.8	1.4	-0.8	1.2	0.5	0.9
Hypothyroidism (self reported)	1.1	2.6	8.4	0.4	-2.9	-1.4	0.1
Respiratory disease	0.6	1.3	2.9	1.7	-1.5	-0.1	0.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.4	0.4	-0.4	1.0	1.6
Lung FEV1/FVC ratio	1.5	7.6	19.8	-4.5	3.2	-0.2	-0.4
Lung FVC	0.2	1.1	2.2	0.5	-0.2	-1.5	-1.4
Neuroticism	2.0	4.8	12.5	-2.4	3.5	-0.5	0.7
Chronotype (morning person)	0.2	0.5	1.9	0.3	-1.4	-0.3	-0.2
Hair Pigment	0.0	0.1	0.2	0.1	-0.4	-0.4	-0.4
Tanning	0.1	1.7	4.7	-2.2	1.3	0.7	-0.1
Hand grip strength (left)	1.6	4.3	5.7	2.4	-2.1	-1.3	-2.3
Number of treatments/medications taken	0.4	0.7	1.4	1.0	-1.2	0.2	0.6
Average weekly spirits intake	1.3	1.6	3.8	-0.7	-0.8	-1.9	-1.1
Sensitivity / hurt feelings	2.8	4.7	8.8	-2.4	3.0	1.2	1.6
Frequency of depressed mood in last 2 weeks	1.9	2.7	7.7	-1.6	2.8	0.1	0.7
Hearing difficulty/problems: Yes	1.0	1.6	2.7	-1.6	0.4	-0.9	-1.7
Relative age of first facial hair	2.9	6.0	18.0	4.2	-0.7	2.2	0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	-0.2	-0.6	0.3	-0.7
Ever used hormone-replacement therapy (HRT)	1.6	2.0	5.9	-2.4	-0.8	-1.1	0.5
Ever had hysterectomy (womb removed)	1.9	2.1	4.2	-0.6	-2.0	-2.1	0.2
Systolic blood pressure, automated reading	0.3	0.9	1.4	1.2	-0.4	1.0	1.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.8	-0.1	1.7	0.7	0.4
Angina	1.0	1.3	3.0	1.3	-0.6	1.7	0.6
Medication for hormone replacement therapy	1.1	1.2	2.3	-1.5	0.5	-1.3	-0.7
Vitamin and mineral supplements	0.6	0.8	1.4	1.1	-0.7	1.2	-0.2
Supplements: Zinc	0.6	0.7	1.2	0.8	-0.0	1.0	1.1
Medication: Co-codamol	0.3	0.4	0.9	-0.1	0.2	0.9	0.8
Medication: Metformin	1.1	1.5	3.1	-0.9	1.2	0.9	1.8
Diabetes (father)	0.8	0.9	2.5	-1.1	1.6	-0.3	0.1
Diabetes (mother)	0.2	0.2	0.4	0.3	-0.6	0.4	0.5
Severe depression (siblings)	0.5	0.5	1.1	-0.7	0.6	0.4	1.1
Pack years adult smoking proportion	0.2	0.3	0.8	-0.9	-0.2	-0.6	0.0
Impedance of leg (right)	3.4	16.5	44.0	6.6	-4.2	1.9	0.9
Leg fat-free mass (left)	1.4	7.3	22.8	-4.8	2.3	-1.0	0.1
Trunk fat percentage	0.2	0.6	2.4	-1.5	-0.3	0.3	0.3
Hand grip strength (right)	0.6	1.6	3.0	0.3	-0.4	-1.7	-1.7
Townsend deprivation index at recruitment	0.5	0.6	0.8	-0.7	-0.7	-0.9	-0.9
Current tobacco smoking	0.4	0.7	1.4	-1.1	-0.5	-0.1	-1.2
Average weekly fortified wine intake	0.2	0.2	0.5	0.7	-0.0	-0.2	0.6
Maternal smoking around birth	1.1	1.6	3.7	-1.9	1.5	-0.5	-0.5
Fed-up feelings	1.2	2.2	5.5	-1.7	2.3	-0.5	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.6	3.5	7.2	-2.7	2.3	0.5	1.0
Relative age voice broke	1.2	1.9	5.9	2.4	-0.1	1.1	0.7
Taking other prescription medications	1.6	2.4	4.1	2.0	-1.7	1.2	1.2
Age when periods started (menarche)	3.6	8.6	19.1	4.4	-2.9	2.6	-0.0
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	5.1	-2.3	-1.6	-1.6	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	4.1	-2.0	1.2	-1.5	0.7
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.6	0.0	0.3	-0.2
Qualifications: CSEs or equivalent	0.8	1.1	2.2	0.8	-1.1	0.6	1.5
Serious illness, injury or assault to yourself	0.6	0.8	1.6	-0.9	-0.6	0.4	-1.3
High blood pressure	0.3	0.9	2.6	-1.6	0.8	-0.2	-0.7
Hayfever, allergic rhinitis or eczema	0.7	1.6	4.0	2.0	-1.3	0.6	0.3
Multivitamins +/- minerals	1.0	1.3	2.1	-1.2	0.7	-1.4	1.1
Stomach or abdominal pain in last month	1.6	2.0	4.0	-2.0	1.2	-1.5	0.3
Supplements: Glucosamine	0.4	0.6	1.3	0.4	-1.1	0.3	-0.9
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	4.6	-1.3	-0.4	-2.1	-1.5
Medication: Atenolol	0.0	0.1	0.2	-0.2	-0.4	-0.2	0.1
Medication: Levothyroxine sodium	1.5	2.6	7.9	0.9	-2.8	-1.3	-0.1
Sitting height	0.1	0.5	1.3	0.0	0.0	1.1	0.9
Chronic bronchitis/emphysema (father)	1.2	1.4	3.0	-1.7	1.6	0.1	-0.2
High blood pressure (mother)	0.3	0.4	1.1	1.1	0.7	0.1	0.3
Body mass index (BMI)	1.5	6.5	20.1	-4.5	1.3	-1.8	-0.9
Impedance of leg (left)	3.1	15.0	38.0	6.2	-4.2	1.9	0.7
Leg predicted mass (left)	1.4	7.4	23.2	-4.8	2.3	-1.1	0.0
Trunk fat mass	0.4	1.6	6.2	-2.5	0.1	-0.3	0.2
Waist circumference	0.5	1.9	7.2	-2.7	0.3	-0.4	0.5
Number of incorrect matches in round	1.4	2.4	4.9	-0.8	1.8	0.8	-2.2
Past tobacco smoking	1.0	1.9	4.7	2.2	-0.8	0.9	1.2
Alcohol usually taken with meals	0.0	0.1	0.2	-0.2	0.4	-0.2	0.2
Nervous feelings	1.6	2.9	9.1	-0.5	3.0	1.4	0.6
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	4.3	-1.6	2.1	-1.6	-0.8
Hearing difficulty/problems with background noise	1.4	2.3	7.2	-2.7	0.5	-1.0	-0.9
Hair/balding pattern: Pattern 2	1.4	1.8	2.4	0.6	-1.5	-1.5	-1.5
Had menopause	0.9	1.1	1.8	-1.3	-1.3	-0.7	0.8
Had other major operations	3.0	3.7	12.1	-3.5	-0.0	-1.6	-0.3
Forced vital capacity (FVC)	0.2	0.7	2.1	0.6	0.1	-1.4	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	4.2	-2.1	1.0	-1.3	0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	0.0	0.6	-0.5	0.7
Qualifications: None of the above	0.2	0.4	0.8	-0.1	0.8	0.0	-0.9
Financial difficulties in last 2 years	0.8	1.0	2.6	-1.0	0.2	-1.6	0.8
Mouth/teeth dental problems	1.2	1.8	4.0	-0.2	2.0	1.2	1.3
Heart attack	0.5	0.6	1.5	0.3	-0.6	0.6	1.2
Allergy	0.5	1.1	2.3	-1.5	1.3	-0.3	-0.7
Pain all over the body in last month	0.5	0.6	1.1	-0.7	-1.1	-0.1	-0.8
Diabetes (self-reported)	0.1	0.1	0.1	-0.3	0.2	0.3	0.4
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.9	0.8	-1.0	-0.5	-1.4
Medication: Ramipril	0.7	0.9	1.7	-1.3	-1.0	-0.9	0.3
Medication: Simvastatin	0.4	0.6	2.3	0.1	-0.2	-1.5	-0.1
Fluid intelligence score	0.2	0.5	1.2	0.3	-0.7	-0.2	-1.1
Illnesses of siblings	2.7	3.8	6.7	2.6	1.3	2.6	-0.2
Neuroticism score	3.0	6.3	19.1	-2.4	4.4	0.3	0.8
Weight	0.9	4.4	15.3	-3.9	1.0	-1.1	-0.3
Impedance of arm (right)	3.1	14.6	37.0	6.1	-1.7	3.8	2.1
Arm fat percentage (right)	0.3	1.0	3.5	-1.9	0.7	0.1	0.4
Trunk fat-free mass	0.9	5.1	15.6	-4.0	1.6	-1.4	-0.4
Hip circumference	0.3	1.3	4.3	-2.1	1.0	-0.1	-0.2
Time employed in main current job	0.3	0.4	0.9	0.7	-0.3	-0.0	-1.0
Alcohol intake versus 10 years previously	0.1	0.1	0.3	-0.4	0.1	-0.5	-0.2
Father’s age at death	0.9	1.2	2.9	0.2	1.7	1.4	0.3
Worrier / anxious feelings	1.4	2.7	6.0	-1.3	2.4	1.0	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	4.4	-1.7	2.1	0.1	-0.7
Falls in the last year	0.6	0.8	3.0	0.4	-1.7	0.3	-0.1
Hair/balding pattern: Pattern 3	1.0	1.5	4.0	2.0	-0.5	1.2	0.5
Number of live births	0.2	0.3	0.9	-0.7	0.9	0.2	0.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.2	-0.5	1.1	-1.5	-0.7
Pulse rate	0.5	0.9	1.6	-0.8	-1.0	-0.5	-1.3
Happiness	1.3	1.6	5.5	0.4	0.9	-0.3	2.3
Noisy workplace	0.6	0.7	1.3	-0.8	-1.1	-0.0	-1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.0	1.6	-1.3	1.2	-0.8	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.3	-1.1	0.1	-1.1	-0.1
Mouth/teeth dental problems: Dentures	1.1	1.9	4.6	0.2	-2.1	0.7	1.5
Asthma	0.4	0.9	2.7	1.6	-0.5	0.4	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.3	0.0	-0.6	-0.2	-1.5
Medication: Cholesterol lowering	0.2	0.3	0.6	0.7	0.2	-0.8	-0.1
Depression (self-reported)	0.2	0.2	0.5	-0.1	0.4	0.4	0.7
Medication: Lansoprazole	0.2	0.2	0.5	0.3	-0.7	0.2	-0.3
Prospective memory result	1.8	2.3	5.1	1.4	-0.4	2.3	1.3
Lung cancer (father)	1.1	1.3	2.6	0.0	-0.5	-1.5	-1.6
Illnesses of mother	0.5	0.6	1.1	0.7	-0.9	0.1	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.9	-0.2	0.9	-1.4	-0.2
Pulse wave Arterial Stiffness index	0.7	0.8	1.8	1.3	-1.1	-0.3	-0.4
Impedance of arm (left)	2.7	12.3	30.0	5.5	-1.1	3.9	1.7
Arm fat mass (right)	0.9	3.8	13.0	-3.6	1.4	-0.6	0.2
Trunk predicted mass	0.9	5.0	15.1	-3.9	1.6	-1.4	-0.5
Standing height	0.1	1.0	1.6	0.7	-0.6	1.2	1.3
Length of working week for main job	0.6	0.7	1.6	-0.9	-0.1	-1.2	-0.7
Exposure to tobacco smoke at home	1.6	1.8	3.7	-0.4	1.9	1.9	0.1
Breastfed as a baby	1.8	2.2	3.4	-0.4	-1.7	-1.8	-1.5
Tense / ‘highly strung’	0.3	0.5	1.5	-0.5	1.2	-0.1	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	3.2	4.9	13.5	-2.1	3.7	1.0	0.6
Hair/balding pattern: Pattern 4	1.2	2.8	6.9	-2.6	2.0	0.6	-0.2
Birth weight of first child	0.1	0.2	0.3	-0.5	0.3	0.4	0.5
Peak expiratory flow (PEF)	1.1	2.5	6.7	-2.6	0.1	-1.8	-0.5
Pulse wave reflection index	0.4	0.4	1.6	0.0	1.2	-0.4	-0.1
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.5	-0.3	0.9	0.3	1.2
Loud music exposure frequency	1.0	1.1	2.1	-1.4	0.9	-1.2	-0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.5	-0.7	0.1	-0.2	0.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.8	0.2	-0.7	-0.4	-1.7
Blood clot in the leg (DVT)	2.3	3.0	4.0	-2.0	-1.5	-2.0	-1.4
Medication: Paracetamol	0.4	0.6	1.1	-0.8	0.4	-1.0	-0.7
Headache pain in last month	1.8	3.2	6.8	-2.6	0.4	-1.8	-1.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.1	0.0	-0.1	0.7	1.0
Glaucoma (self-reported)	0.7	0.8	2.5	-0.1	-1.6	-0.8	-0.1
Gout (self-reported)	1.3	1.8	4.5	-2.1	0.6	-1.4	-0.6
Hypothyroidism/myxoedema (self-reported)	1.6	3.0	9.4	1.3	-3.1	-1.1	-0.2
Medication: Amlodipine	0.7	0.9	1.3	1.1	0.9	0.8	1.0
Medication: Ventolin 100micrograms inhaler	0.8	1.1	3.4	1.9	0.4	0.9	-0.1
Birth weight	0.2	0.4	0.6	0.0	-0.8	0.5	0.7
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.7	-0.2	-0.8	-0.8	0.6
High blood pressure (siblings)	2.3	3.3	6.0	-2.5	-0.1	-2.4	-1.1
Forced vital capacity (FVC), Best measure	0.2	0.7	1.8	0.8	0.6	-1.3	-0.2
Body fat percentage	0.1	0.5	1.8	-1.3	-0.6	0.0	0.1
Leg fat percentage (right)	0.3	0.9	2.1	-1.0	-1.4	-0.7	-0.3
Arm fat-free mass (right)	1.4	6.9	23.3	-4.8	1.1	-1.8	-0.4
Exposure to tobacco smoke outside home	3.0	4.0	9.4	-0.9	-1.1	-3.1	-2.1
Comparative body size at age 10	3.2	8.9	30.6	-5.5	2.0	-1.1	0.2
Number of full brothers	0.1	0.2	0.5	0.1	-0.7	-0.2	0.3
Worry too long after embarrassment	1.0	1.7	4.1	-1.0	2.0	1.0	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	4.6	-0.9	2.2	0.8	0.5
Wheeze or whistling in the chest in last year	0.3	0.6	1.9	0.6	-0.0	1.4	0.1
Number of children fathered	0.3	0.3	0.8	-0.3	0.9	0.7	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.1	0.4	0.8	1.8	1.1
Age at first live birth	0.2	0.3	0.8	-0.0	0.9	-0.5	-0.3
Pulse wave peak to peak time	0.7	0.9	1.8	-1.4	1.2	0.4	0.4
Health satisfaction	0.5	0.6	1.4	-1.0	1.2	-0.1	0.2
Shortness of breath walking on level ground	0.2	0.3	0.7	-0.8	0.2	-0.2	0.6
Qualifications: College or University degree	0.4	1.2	2.9	0.1	1.3	1.7	0.5
Eye problems/disorders: None of the above	0.8	0.9	1.2	0.7	1.0	1.1	1.0
Mouth/teeth dental problems: Loose teeth	1.5	1.7	4.5	-2.1	0.8	-0.8	-1.1
Emphysema/chronic bronchitis	0.3	0.3	0.8	-0.9	-0.3	-0.2	0.5
Medication for pain relief, constipation, heartburn	0.3	0.4	1.2	-0.5	-0.3	-1.1	0.4
Neck or shoulder pain in last month	1.9	2.7	6.6	-1.2	-0.6	-1.6	-2.6
Medication: Blood pressure	0.1	0.1	0.2	-0.1	-0.3	0.4	-0.4
Angina (self-reported)	1.2	1.5	2.7	1.5	-0.9	1.6	0.7
Migraine (self-reported)	0.1	0.2	0.5	0.2	0.2	-0.7	-0.4
Medication: Ibuprofen	0.8	1.0	3.4	-0.3	-0.7	-0.3	-1.8
Medication: Allopurinol	1.0	1.3	3.0	-1.7	1.2	-0.7	0.5
Medication: Omeprazole	3.1	3.6	7.2	1.4	1.7	2.7	1.6
Medication: Seretide 50 evohaler	1.5	1.8	3.3	1.4	-1.3	0.3	1.8
Mean time to correctly identify matches	0.9	1.8	4.8	-2.2	1.0	-0.7	-1.0
Heart disease (mother)	1.1	1.3	2.2	0.0	1.5	1.1	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.7	1.3	-0.3	0.8	0.2
Whole body fat mass	0.5	2.2	8.6	-2.9	0.3	-0.4	0.2
Leg fat mass (right)	0.6	2.4	8.3	-2.9	-0.3	-1.1	-0.4
Arm predicted mass (right)	1.3	6.6	22.4	-4.7	1.4	-1.4	-0.3
Pulse rate, automated reading	0.2	0.8	2.1	0.8	-1.4	-0.1	-0.7
Alcohol intake frequency.	0.3	0.6	1.6	-0.1	-1.3	0.4	0.8
Comparative height size at age 10	0.1	0.5	1.4	-0.7	-0.1	0.4	1.2
Number of full sisters	0.5	0.6	0.8	-0.6	-0.8	0.9	0.8
Suffer from ‘nerves’	0.9	1.4	2.7	-1.4	1.6	0.6	0.8
Overall health rating	0.7	1.5	3.8	-2.0	-0.5	-1.1	-0.8
Chest pain or discomfort	1.2	1.8	5.4	0.6	-2.3	-0.5	-1.1
Had major operations	0.3	0.4	0.8	0.5	-0.9	0.5	0.3
Age at last live birth	0.1	0.1	0.2	0.4	0.0	0.0	0.3
Family relationship satisfaction	1.8	2.2	4.3	-1.8	1.2	-2.1	-0.2
Leg pain on walking	0.1	0.1	0.3	-0.5	-0.0	0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	6.0	-1.6	-0.4	-2.4	-0.3
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.7	-1.6	-0.2	-0.7	1.3
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	4.2	2.1	-0.9	1.1	0.4
Medication: Aspirin	1.2	1.6	4.6	1.4	0.2	2.1	-0.1
Supplements: Vitamin C	0.4	0.5	0.9	0.3	-0.8	-0.6	-0.9
Knee pain experienced in last month	1.1	1.7	4.1	-2.0	-0.5	-1.6	0.2
Hypertension (Self-reported)	0.4	1.0	2.6	-1.6	1.0	-0.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	2.1	0.4	1.4	0.5	1.4
Illnesses of father: Heart disease	0.8	1.1	2.9	-1.1	-0.6	0.2	1.7
Illnesses of siblings: Diabetes	1.0	1.3	1.9	-0.9	-1.0	-1.4	1.1
Smoking status: Previous	1.2	1.8	5.3	-2.3	0.8	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.2	0.8	-0.2	-1.5	-1.8
Whole body fat-free mass	1.2	6.6	20.8	-4.6	1.9	-1.4	-0.3
Leg fat-free mass (right)	1.4	7.7	23.7	-4.9	2.5	-0.9	0.0
Arm fat percentage (left)	0.3	1.4	5.0	-2.2	0.7	0.0	0.2
Average weekly red wine intake	0.1	0.2	0.3	0.2	0.6	0.4	0.5
Handedness (chirality/laterality): Left-handed	1.3	1.5	2.0	-0.7	-1.3	-1.4	-1.4
Mood swings	2.3	4.1	9.2	-2.7	3.0	-0.1	-0.0
Loneliness, isolation	4.5	6.2	17.0	-4.1	0.8	-2.7	-0.1
Long-standing illness, disability or infirmity	0.1	0.2	0.7	-0.8	-0.1	0.0	-0.3
Ever had bowel cancer screening	0.2	0.3	0.9	-0.1	-1.0	-0.2	-0.2
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.5	0.3	0.3	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.6	-0.1	0.8	1.0	1.6
Friendships satisfaction	0.9	1.1	3.2	-0.4	1.8	-0.9	0.7
Qualifications: nursing, teaching	0.4	0.7	1.8	-1.4	0.2	0.6	0.7
Commuting to job workplace: Walk	0.2	0.2	0.7	0.8	0.2	0.4	0.1
Eye problems/disorders: Cataract	0.7	0.8	1.4	-0.8	-1.2	-0.8	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.7	0.7	0.1	-0.8	0.8
Medication for cholesterol	1.0	1.4	4.5	2.1	-0.7	0.8	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.2	8.6	-1.6	2.9	1.2	0.7
Back pain experienced in last month	0.7	1.0	2.1	-0.4	1.5	1.2	0.7
Mineral and other dietary supplements	1.6	2.2	5.4	-0.4	2.3	0.8	1.6
Breast cancer (self-reported)	0.8	0.9	2.0	1.4	0.4	0.7	1.0
Asthma (self-reported)	0.4	0.8	1.8	1.4	-0.3	0.5	0.9
Osteoporosis (self-reported)	2.1	2.7	7.1	-0.5	0.5	2.7	1.7
Osteoarthritis (self-reported)	0.4	0.6	1.5	0.2	-1.2	-0.8	0.1
Medication: Aspirin	1.6	2.1	4.6	1.9	0.0	2.1	-0.0
Medication: Gliclazide	0.6	0.7	1.1	0.8	0.9	1.1	0.5
Illnesses of father: None of the above (group 1)	0.7	0.8	1.7	0.7	-1.0	-1.3	-0.4
Smoking status: Current	0.4	0.6	1.5	-0.8	-0.4	0.2	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.3	-0.0	-0.1	-1.0	-1.1
Whole body water mass	1.2	6.6	20.8	-4.6	2.0	-1.2	-0.2
Leg predicted mass (right)	1.5	8.1	24.9	-5.0	2.5	-1.0	-0.1
Arm fat mass (left)	0.9	3.8	13.0	-3.6	1.4	-0.4	-0.0
Number of self-reported non-cancer illnesses	0.3	0.6	1.1	0.7	-0.9	-1.1	-0.1
Average weekly champagne plus white wine intake	0.5	0.7	1.2	0.5	1.1	0.3	1.1
Miserableness	3.5	6.0	16.8	-2.0	4.1	1.0	1.5
Guilty feelings	1.8	2.8	8.6	-0.9	2.9	0.3	1.3
Wears glasses or contact lenses	2.0	2.3	5.2	0.8	-2.3	-1.6	-0.9
Ever taken oral contraceptive pill	1.5	1.7	2.6	1.6	-0.8	-1.1	-1.5
Hearing aid user	0.9	1.1	1.6	-1.2	1.3	0.7	0.9
Mother’s age at death	0.4	0.5	1.7	0.2	1.3	0.4	0.3
Financial situation satisfaction	1.9	2.4	6.8	-1.5	0.6	-2.6	0.3
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.4	-1.6	1.3	-0.8	0.2
Commuting to job workplace: Public transport	2.1	2.5	3.6	1.9	-1.6	-1.3	-1.4
Eye problems/disorders: Glaucoma	0.5	0.6	1.9	-0.4	-1.4	-0.5	0.3
Medication: Blood pressure	1.2	2.2	7.9	-2.8	0.9	-0.1	-0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.8	-0.9	-0.3	-0.1	0.1
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.0	0.5	-1.7	-1.5	-0.9
High cholesterol (Self-reported)	0.1	0.2	0.3	-0.6	0.5	-0.6	0.3
Medication: Bendroflumethiazide	1.3	2.0	3.3	-1.8	-0.0	-1.3	-1.8
Medication: Paracetamol	0.6	0.9	1.6	-1.2	0.4	-1.3	-0.5
Medication: Lisinopril	0.7	0.9	3.1	-0.3	-0.6	0.1	-1.8
Medication: Atorvastatin	1.2	1.5	2.2	-1.0	0.9	1.5	1.5
Illnesses of father: High blood pressure	0.8	1.0	1.7	-1.3	1.2	0.6	-0.7
Alcohol drinker status: Never	1.3	1.6	3.2	-0.8	0.4	1.6	1.8
Ever smoked	1.3	2.3	3.4	-1.7	1.0	-1.4	-1.9
Basal metabolic rate	1.1	6.3	20.3	-4.5	1.9	-1.2	-0.2
Leg fat percentage (left)	0.3	1.2	2.4	-1.6	-1.4	-0.7	-0.3
Arm fat-free mass (left)	1.0	5.0	17.2	-4.2	1.1	-1.3	-0.2
Number of operations (self-reported)	1.4	2.1	5.7	-2.4	-0.2	-1.4	-0.9
Average weekly beer plus cider intake	0.3	0.4	1.5	-1.2	-0.0	0.3	0.3
Irritability	1.1	1.8	4.0	-1.6	2.0	0.4	0.8
Risk taking	1.6	2.4	3.8	0.9	-1.9	-1.2	-1.9
Ever had prostate specific antigen (PSA) test	2.3	2.7	7.0	1.9	-2.6	0.1	-0.0
Fractured/broken bones in last 5 years	1.0	1.3	2.6	0.8	-0.6	1.2	1.6
Age started oral contraceptive pill	1.6	2.0	3.2	0.2	-1.8	-1.4	-1.6
Diastolic blood pressure, automated reading	0.3	1.1	2.4	0.1	-1.3	-1.5	-0.6
Ever depressed for a whole week	0.3	0.4	0.6	0.7	0.7	0.4	0.8
Unable to work because of sickness or disability	0.9	1.1	2.1	0.1	1.2	1.5	0.9
Commuting to job workplace: Cycle	1.8	2.1	6.2	-1.1	2.5	0.9	0.4
Myopia	0.5	0.7	1.3	-0.9	0.8	-0.1	1.2
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.4	1.2	-0.5	-0.1	0.4
Cholesterol lowering medication	0.9	1.3	3.9	-2.0	0.6	-0.7	0.4
Medication: Omeprazole (e.g. Zanprol)	2.8	3.4	7.5	1.3	1.2	2.7	1.7
Pain experienced in last month	1.9	3.2	10.6	3.2	-0.9	1.0	0.7
Supplements: Calcium	0.5	0.5	1.6	1.2	-0.5	0.5	0.3
Basal cell carcinoma (self-reported)	1.0	1.2	1.7	0.9	1.0	1.3	1.3
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.5	0.4	-0.8	0.3	1.2
Deep venous thrombosis (DVT) (self-reported)	2.6	3.3	5.0	-2.2	-1.5	-2.0	-1.3
Heart disease (siblings)	0.6	0.8	1.4	0.6	-0.6	1.0	1.2
Alcohol drinker status: Previous	0.9	1.0	2.3	-0.5	-1.5	-0.6	-1.1
Pack years of smoking	0.2	0.2	0.8	-0.9	-0.0	-0.4	0.1
Impedance of whole body	2.8	14.4	37.0	6.1	-2.5	3.4	1.7
Leg fat mass (left)	0.7	2.8	9.7	-3.1	-0.3	-1.0	-0.5
Arm predicted mass (left)	1.1	5.4	17.8	-4.2	1.0	-1.6	-0.3