Hub : Genes

TNFRSF11B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0583	0.0209	1.1e-04	0.038	0.043	0.037	0.043	0.034	1.0e-05	2.6e-06	1.3e-05	2.5e-06	2.7e-05
2	TCGA	Colon Adenocarcinoma	0.0990	0.0460	8.0e-04	-0.004	0.054	0.019	NA	0.006	7.7e-01	4.4e-04	2.7e-02	NA	1.3e-01
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0557	0.0277	1.4e-03	0.038	0.021	0.036	NA	0.041	4.0e-05	1.8e-03	5.5e-05	NA	1.8e-05
4	TCGA	Lung Adenocarcinoma	0.0457	0.0209	5.2e-05	0.050	0.025	0.029	NA	0.041	1.6e-06	5.4e-04	2.3e-04	NA	1.4e-05
5	TCGA	Stomach Adenocarcinoma	0.0470	0.0250	6.0e-03	0.025	0.019	0.011	NA	0.024	6.2e-03	1.5e-02	4.7e-02	NA	6.8e-03
6	TCGA	Thyroid Carcinoma	0.0580	0.0300	6.4e-04	0.047	0.033	0.014	NA	0.035	2.0e-05	3.3e-04	1.4e-02	NA	2.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.4	0.6	2.0	1.4	-0.9	-0.2	-0.6	0.6	-0.5
Bipolar Disorder or Schizophrenia	0.6	1.5	3.9	1.7	-0.4	-1.0	-0.9	-0.4	-2.0
Depressed Affect (Nagel 2018)	1.1	2.4	4.2	-2.0	0.4	1.4	2.1	-0.1	2.0
Depression (Nagel 2018)	0.9	1.4	3.1	-0.8	0.8	1.7	1.8	0.3	1.1
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.4	0.3	-1.5	-1.3	-1.3	0.8	-0.3
Neuroticism (Nagel 2018)	1.1	2.6	7.5	-1.4	0.2	1.3	2.7	0.1	2.2
Schizophrenia (2018)	0.7	1.4	4.6	1.1	0.2	-1.1	-0.8	-0.9	-2.1
Schizophrenia vs Biploar Disorder	1.6	2.1	5.4	0.3	-0.7	-0.5	-1.8	-1.8	-2.3
Worry (Nagel 2018)	1.6	3.3	7.6	-1.8	0.7	1.4	2.8	1.0	2.4
Alzheimer’s Disease (in mother)	0.3	0.4	1.2	-0.7	0.2	1.1	0.2	-0.0	0.8
Alzheimer’s Disease (in father)	0.5	0.5	1.4	-0.6	0.6	-0.4	1.2	0.8	0.6
Alzheimer’s Disease (including proxy)	0.4	0.6	1.5	-1.1	0.3	0.3	1.2	0.4	0.7
Crohns Disease (2017)	3.3	7.3	11.4	2.9	-2.2	-0.4	-3.1	-3.1	-3.4
Irritable Bowel Disease (IBD)	2.6	6.2	9.1	2.5	-3.0	-1.1	-2.4	-2.8	-2.6
Ulcerative Colitis (UC)	2.1	3.9	10.0	1.9	-3.2	-1.5	-1.6	-1.9	-1.3
Major Depression (MDD)	0.5	0.6	1.4	1.2	0.1	0.2	0.0	-1.1	-0.9
Reaction Time	0.3	0.6	1.8	-0.5	1.3	0.8	0.5	-0.8	0.3
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.6	-0.8	-0.3	-0.8	-0.1	1.6	-0.0
Breast Cancer	0.1	0.2	0.6	0.1	0.6	0.7	0.1	-0.7	0.1
Ovarian Cancer	0.4	0.6	1.6	0.4	0.2	-1.2	-0.4	1.3	0.2
Prostate Cancer	3.0	4.3	9.1	-1.9	2.2	-1.2	2.3	3.0	0.9
Age at First Birth	0.5	0.7	1.3	-0.8	-0.6	-1.0	0.8	1.1	0.3
Bipolar Disorder (2011)	0.3	0.3	0.9	0.2	0.6	0.4	-0.1	0.9	0.4
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	0.9	-0.7	-0.2	-0.7	-0.6	-0.7
Coronary Artery Disease (CAD)	0.6	0.7	2.0	-0.7	0.8	1.4	-0.9	-0.2	0.3
Crohns Disease (2012)	1.0	1.6	3.1	1.2	0.1	0.7	-1.8	-1.3	-1.7
Mean Putamen Volume	0.4	0.4	1.2	-0.6	-1.1	-0.1	-0.1	-0.6	0.7
Fasting Glucose	0.5	0.5	1.0	-1.0	-0.2	0.9	0.6	-0.2	1.0
HbA1C	1.4	1.6	4.4	0.9	-2.1	-2.0	-0.1	0.5	0.1
HDL Cholesterol	0.5	0.8	2.0	1.1	1.4	1.2	0.3	-0.2	0.3
LDL Cholesterol	0.3	0.5	1.7	-0.5	0.1	-0.4	0.2	1.3	0.7
Lupus	1.9	2.8	5.9	2.4	-1.0	-1.4	-1.9	-1.2	-1.8
Neuroticism (2016)	0.3	0.4	1.0	-0.5	1.0	-0.2	1.0	0.2	0.1
Primary Biliary Cirrhosis	1.2	1.7	3.2	-1.0	0.0	-0.6	1.8	1.7	1.6
Rheumatoid Arthritis	0.1	0.2	0.3	-0.1	0.1	0.5	0.3	0.6	0.5
Schizophrenia (2014)	0.7	1.6	5.4	1.3	-0.0	-1.0	-0.8	-1.0	-2.3
Triglycerides	0.2	0.4	1.0	0.2	-0.3	0.9	0.3	1.0	0.5
Type 2 Diabetes (T2D) (2012)	3.1	3.5	7.5	-0.4	2.7	2.0	1.9	1.1	2.2
Ulcerative Colitis	0.2	0.3	0.6	0.3	-0.8	-0.6	-0.4	-0.7	0.1
Blood Eosinophil Count	1.9	14.8	26.8	-5.2	-1.3	-1.6	4.4	4.0	4.7
Blood Platelet Count	0.1	0.8	2.3	0.2	-1.3	1.5	0.4	-0.1	0.7
Blood Red Count	0.6	6.0	11.9	1.4	-2.1	-3.1	-3.5	-0.7	-2.9
Blood White Count	0.3	2.2	3.8	1.6	-0.9	0.2	-1.6	-1.9	-1.9
Heel T-Score	1.8	14.7	53.4	-0.1	0.9	4.3	7.3	1.1	3.7
BMI	0.3	1.5	2.4	1.4	-1.0	-0.7	-1.6	-1.1	-1.5
Height	0.0	0.7	1.7	1.3	0.2	-0.9	1.1	0.0	-0.8
Waist Hip Ratio (WHR)	2.2	10.1	15.3	2.3	-3.7	-2.9	-3.9	-2.5	-3.4
Systolic Blood Pressure	0.7	3.4	14.1	-0.6	-0.4	-1.8	1.3	3.8	1.0
Smoking Status	0.1	0.3	0.4	0.7	0.6	0.5	0.6	-0.5	-0.1
Allergy or Eczema	0.4	1.1	2.6	0.0	-0.5	-1.6	-1.1	0.0	-1.6
Cardiovascular Disease	0.1	0.5	1.5	1.2	-0.6	-0.3	0.7	0.6	-0.0
Hypothyroidism (self reported)	4.4	10.1	19.8	-4.5	0.3	0.8	4.3	2.2	4.1
Respiratory disease	6.2	13.7	19.8	4.0	-3.3	-2.0	-3.8	-4.5	-4.0
Type 2 Diabetes (T2D) (2018)	1.0	1.8	4.8	-0.2	-0.6	1.5	2.2	0.9	1.6
Lung FEV1/FVC ratio	0.1	0.5	1.5	-0.0	0.1	-0.3	0.5	1.0	1.2
Lung FVC	0.1	0.6	1.5	1.2	-1.1	0.3	-0.4	-0.7	-0.1
Neuroticism	1.8	4.3	9.5	-2.6	0.5	1.8	3.1	0.2	2.5
Chronotype (morning person)	0.4	0.9	3.0	-1.7	0.1	0.0	0.5	1.1	1.1
Hair Pigment	0.0	0.7	2.2	0.4	-1.5	0.1	-0.6	-1.2	-0.2
Tanning	0.2	2.0	5.1	-1.8	-1.9	0.4	0.2	-2.2	0.3
Hand grip strength (left)	0.2	0.6	1.6	1.2	0.4	0.1	-1.1	-0.1	-0.9
Number of treatments/medications taken	0.9	1.6	3.8	-1.1	-0.0	-0.1	1.9	1.8	1.1
Average weekly spirits intake	0.7	0.8	1.5	-0.6	0.2	-1.2	1.2	1.2	0.6
Sensitivity / hurt feelings	1.8	3.0	6.3	-1.6	1.4	2.0	2.5	-0.2	1.8
Frequency of depressed mood in last 2 weeks	2.1	2.9	5.6	-1.3	1.0	2.0	2.4	0.9	2.1
Hearing difficulty/problems: Yes	2.0	3.0	8.9	1.2	-2.0	-0.2	-1.4	-3.0	-1.3
Relative age of first facial hair	0.8	1.7	3.7	1.2	-1.0	-1.9	-0.6	-0.5	-1.8
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	4.5	-2.1	0.3	0.3	1.2	0.5	1.4
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.7	0.4	0.6	-0.7	-0.2	0.4	-0.8
Ever had hysterectomy (womb removed)	0.2	0.3	0.5	0.5	-0.1	-0.6	0.7	0.7	0.3
Systolic blood pressure, automated reading	0.5	1.3	4.1	-0.8	-0.9	-1.5	0.6	2.0	0.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.1	1.1	-0.1	0.6	0.9	-0.2	0.9
Angina	1.1	1.5	2.3	1.5	-1.5	-0.3	-1.5	-1.2	-0.6
Medication for hormone replacement therapy	1.2	1.3	3.9	-1.2	2.0	0.8	0.9	1.0	0.2
Vitamin and mineral supplements	1.4	2.0	5.3	1.3	-2.3	-1.0	-1.4	-1.0	-0.7
Supplements: Zinc	2.2	2.4	3.5	1.8	-1.7	-0.6	-1.4	-1.9	-1.5
Medication: Co-codamol	0.7	0.9	2.5	0.1	1.1	-1.6	0.7	0.3	-0.9
Medication: Metformin	0.7	1.0	2.1	0.1	-1.5	0.1	1.0	1.2	1.2
Diabetes (father)	1.9	2.4	5.1	-1.6	1.2	1.1	2.3	1.2	1.7
Diabetes (mother)	0.3	0.4	2.2	0.4	-1.5	-0.1	-0.1	-0.1	0.3
Severe depression (siblings)	0.4	0.4	1.5	0.6	1.2	-0.1	-0.3	-0.3	-0.7
Pack years adult smoking proportion	0.3	0.4	1.2	0.3	1.1	-0.3	0.4	1.0	0.2
Impedance of leg (right)	0.8	4.1	7.1	2.7	-2.3	-1.0	-2.2	-1.5	-2.1
Leg fat-free mass (left)	0.0	0.2	0.4	-0.4	0.7	-0.6	-0.2	-0.4	-0.5
Trunk fat percentage	1.7	6.8	10.7	2.5	-3.0	-3.3	-2.5	-1.2	-2.6
Hand grip strength (right)	0.2	0.6	1.8	1.4	-0.1	1.1	-0.4	-0.4	-0.5
Townsend deprivation index at recruitment	0.6	0.8	1.5	0.5	-0.5	-0.6	-1.0	-1.2	-1.2
Current tobacco smoking	0.3	0.4	2.0	0.6	1.4	0.3	-0.1	0.0	0.1
Average weekly fortified wine intake	1.1	1.3	4.8	-2.2	0.7	-1.4	-0.3	0.6	-0.1
Maternal smoking around birth	0.4	0.5	1.4	0.2	-0.1	-0.6	-0.3	-1.2	-1.1
Fed-up feelings	0.8	1.4	3.0	-1.4	1.1	1.7	0.9	-0.7	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.3	-0.9	-1.1	0.7	0.6	-0.6	0.5
Relative age voice broke	2.7	4.1	7.0	2.4	-1.7	-2.3	-1.1	-1.5	-2.6
Taking other prescription medications	0.4	0.6	1.6	1.0	-0.8	-1.3	-0.2	-0.1	-0.7
Age when periods started (menarche)	0.3	0.6	2.1	0.2	-0.2	0.4	-1.1	-1.5	-0.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	-0.2	-0.3	-0.9	0.7	0.7	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	6.0	-0.5	0.2	2.4	2.1	-0.9	1.3
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.2	1.1	1.8	1.4	0.9	-0.9	-0.6
Qualifications: CSEs or equivalent	0.2	0.3	1.0	0.5	-0.4	0.6	-0.4	-1.0	-0.0
Serious illness, injury or assault to yourself	0.2	0.3	0.8	-0.9	0.1	-0.2	0.6	-0.2	-0.5
High blood pressure	0.4	1.1	2.8	-0.1	-0.2	0.3	1.7	1.6	1.0
Hayfever, allergic rhinitis or eczema	0.2	0.3	1.1	-0.0	0.2	-0.4	0.2	1.1	-0.8
Multivitamins +/- minerals	2.1	2.6	5.8	-1.3	2.4	1.5	1.5	1.7	1.0
Stomach or abdominal pain in last month	0.3	0.4	1.0	0.3	0.2	1.0	-0.8	-0.5	-0.3
Supplements: Glucosamine	0.2	0.2	1.1	-0.4	1.0	0.3	0.1	-0.0	-0.1
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.1	-1.4	-0.5	0.2	0.1	0.6	1.7
Medication: Atenolol	0.7	0.9	2.2	1.5	0.8	-0.2	-0.5	-0.2	-1.4
Medication: Levothyroxine sodium	2.0	3.4	7.6	-2.5	0.3	0.6	2.7	0.4	2.4
Sitting height	3.7	26.4	39.3	-5.6	4.7	4.2	6.3	4.2	5.5
Chronic bronchitis/emphysema (father)	0.4	0.5	1.9	-1.4	0.3	-0.7	0.3	0.4	0.4
High blood pressure (mother)	0.4	0.5	1.0	-0.7	0.8	0.4	1.0	0.8	0.4
Body mass index (BMI)	0.5	2.0	3.4	1.2	-1.2	-1.6	-1.9	-1.1	-1.5
Impedance of leg (left)	0.5	2.6	6.0	2.5	-1.9	-1.1	-1.4	-0.7	-1.6
Leg predicted mass (left)	0.0	0.2	0.4	-0.4	0.6	-0.6	-0.2	-0.4	-0.5
Trunk fat mass	1.4	5.9	9.9	2.4	-2.6	-3.1	-2.3	-1.3	-2.5
Waist circumference	1.9	7.0	11.0	1.9	-2.5	-3.3	-3.3	-1.5	-2.9
Number of incorrect matches in round	0.5	0.8	2.2	0.0	-1.5	-0.7	-0.9	-1.2	-0.1
Past tobacco smoking	0.1	0.3	0.6	0.5	0.6	-0.1	-0.8	0.6	-0.1
Alcohol usually taken with meals	0.9	1.5	3.1	-0.3	-1.4	-0.8	0.4	1.8	1.7
Nervous feelings	1.9	3.5	6.6	-1.9	0.0	0.5	2.5	2.2	2.6
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	3.8	-1.8	1.5	1.1	2.0	1.1	1.9
Hearing difficulty/problems with background noise	3.3	5.3	14.1	2.0	-2.5	0.1	-2.0	-3.8	-1.8
Hair/balding pattern: Pattern 2	3.9	5.0	9.4	1.7	-1.0	-0.4	-3.1	-2.8	-2.9
Had menopause	0.1	0.2	0.6	-0.8	0.1	0.2	0.1	0.5	-0.2
Had other major operations	2.1	2.6	5.8	-0.6	1.9	-1.8	1.4	2.4	0.6
Forced vital capacity (FVC)	0.2	0.8	3.1	1.8	0.1	-0.2	-0.7	-0.4	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.3	8.5	-0.9	0.6	2.6	2.9	-0.1	1.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.9	-0.2	-0.9	0.2	0.9	-0.7	0.0
Qualifications: None of the above	0.4	0.9	2.5	0.0	1.6	0.7	1.1	-1.0	0.2
Financial difficulties in last 2 years	0.2	0.2	0.3	0.6	-0.2	-0.6	0.6	0.5	-0.2
Mouth/teeth dental problems	0.3	0.5	1.5	0.7	-0.5	-1.2	0.4	0.8	-0.1
Heart attack	1.3	1.7	3.7	1.7	-0.7	0.2	-1.9	-1.5	-1.0
Allergy	0.8	1.8	4.7	-1.3	0.4	0.9	1.3	1.2	2.2
Pain all over the body in last month	0.9	1.0	2.7	-0.2	-1.0	-0.6	-0.5	-1.6	-1.3
Diabetes (self-reported)	1.0	1.6	4.5	0.2	-0.3	0.9	2.1	1.1	1.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.8	0.1	0.4	0.6	0.7	0.3	-0.9
Medication: Ramipril	1.9	2.4	8.6	-0.3	0.5	2.9	1.3	1.1	1.6
Medication: Simvastatin	1.0	1.4	3.0	-0.1	1.3	1.4	1.7	0.8	1.1
Fluid intelligence score	0.7	1.6	6.5	-1.1	0.4	-1.1	0.1	2.5	0.2
Illnesses of siblings	1.5	2.1	7.7	-0.2	-0.6	2.8	-0.7	-1.8	1.0
Neuroticism score	1.9	4.0	9.2	-2.0	1.1	2.3	3.0	0.3	2.1
Weight	0.5	2.2	3.6	1.3	-1.0	-1.9	-1.7	-1.1	-1.8
Impedance of arm (right)	0.6	2.6	7.2	2.0	-2.7	-0.4	-1.5	-0.6	-1.4
Arm fat percentage (right)	1.1	4.1	6.1	2.0	-2.5	-2.0	-2.3	-1.5	-1.9
Trunk fat-free mass	0.0	0.3	1.2	-0.5	1.1	-0.1	0.3	-0.3	-0.1
Hip circumference	0.9	3.8	5.9	2.2	-1.5	-2.0	-2.4	-1.2	-2.1
Time employed in main current job	0.3	0.4	1.2	-0.7	-0.7	-1.1	0.0	0.5	0.1
Alcohol intake versus 10 years previously	1.4	2.1	2.7	1.5	-1.3	-1.5	-1.6	-1.4	-1.5
Father’s age at death	0.4	0.5	1.6	-0.8	1.3	0.7	0.5	-0.1	-0.1
Worrier / anxious feelings	1.2	2.3	5.2	-1.3	0.6	1.6	1.9	0.8	2.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.2	0.5	0.4	0.5	1.0	0.2	1.5
Falls in the last year	0.1	0.2	0.5	-0.4	0.4	0.2	-0.1	0.7	-0.3
Hair/balding pattern: Pattern 3	1.0	1.5	4.6	-0.9	0.3	0.0	2.1	1.4	1.1
Number of live births	0.5	0.6	2.0	0.1	1.4	0.9	-0.2	-0.9	-0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.7	1.3	-0.1	0.2	-0.5	0.1	-0.3
Pulse rate	0.1	0.1	0.6	-0.8	-0.3	0.2	-0.3	-0.1	0.2
Happiness	0.6	0.8	1.2	-1.1	-0.3	0.9	1.1	0.2	1.1
Noisy workplace	0.4	0.4	1.3	1.1	0.7	0.6	0.1	-0.4	-0.5
Qualifications: A levels/AS levels or equivalent	0.7	1.7	4.0	1.0	-2.0	0.1	-1.8	-1.2	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.0	-1.4	-0.5	0.3	-0.2	0.6	1.2
Mouth/teeth dental problems: Dentures	0.7	1.2	2.6	-1.6	0.8	1.2	-0.2	-1.6	-0.1
Asthma	5.0	9.8	17.4	4.2	-2.9	-1.9	-2.8	-3.0	-3.5
Medication: Ibuprofen (e.g. Nurofen)	2.5	3.2	9.0	-3.0	0.9	1.6	1.4	1.3	1.7
Medication: Cholesterol lowering	0.2	0.3	1.0	0.4	-0.1	0.1	1.0	0.3	0.5
Depression (self-reported)	0.7	0.9	2.0	1.3	-0.0	-0.2	-1.0	-1.4	-0.9
Medication: Lansoprazole	6.2	7.1	13.2	2.9	-1.7	-1.9	-2.9	-2.5	-3.6
Prospective memory result	0.2	0.3	1.1	-0.2	0.5	0.2	-0.1	-1.0	0.6
Lung cancer (father)	0.0	0.0	0.1	0.3	0.1	-0.2	-0.0	0.1	0.3
Illnesses of mother	0.6	0.7	1.9	0.5	-0.9	0.3	-0.9	-1.4	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.8	0.3	0.6	0.9	0.3	0.3	0.4
Pulse wave Arterial Stiffness index	0.6	0.7	2.1	0.1	-1.2	-1.5	-0.6	-0.5	0.1
Impedance of arm (left)	0.5	2.3	8.4	1.6	-2.9	-0.4	-1.2	-0.3	-0.9
Arm fat mass (right)	1.0	4.0	5.2	1.9	-1.8	-2.1	-2.2	-1.6	-2.3
Trunk predicted mass	0.1	0.3	1.4	-0.6	1.2	-0.0	0.4	-0.3	-0.1
Standing height	0.0	0.2	0.6	0.2	0.4	-0.4	0.6	-0.1	-0.8
Length of working week for main job	0.3	0.3	0.6	-0.8	0.5	-0.1	0.6	0.6	-0.2
Exposure to tobacco smoke at home	4.3	4.8	12.2	-0.7	3.5	0.1	2.3	3.2	0.8
Breastfed as a baby	0.6	0.7	2.5	-0.2	-1.6	1.1	-0.6	-0.4	0.1
Tense / ‘highly strung’	0.3	0.5	1.6	-0.1	0.8	0.4	1.3	0.2	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.7	0.1	-0.8	0.3	-0.6	-1.3	-0.2
Hair/balding pattern: Pattern 4	0.2	0.4	1.0	0.2	1.0	0.6	0.3	-0.0	1.0
Birth weight of first child	0.6	1.2	3.6	-0.1	1.9	1.6	0.6	-0.5	-0.4
Peak expiratory flow (PEF)	0.1	0.1	0.5	0.7	0.2	0.3	0.1	-0.1	-0.4
Pulse wave reflection index	0.3	0.4	1.2	0.3	0.2	0.5	-0.8	-1.1	-0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.8	-1.4	1.1	-0.3	0.7	-0.0	-0.1
Loud music exposure frequency	0.2	0.2	0.9	0.3	-0.0	-0.4	0.1	0.9	0.3
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	4.0	-0.9	1.3	1.3	1.1	1.4	2.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.1	0.3	-0.2	0.6	-1.0	-0.5	-0.0
Blood clot in the leg (DVT)	0.6	0.8	2.2	-0.2	0.4	-1.5	-1.2	-0.5	-1.0
Medication: Paracetamol	3.4	5.7	11.1	-2.2	1.4	2.2	3.3	1.7	2.9
Headache pain in last month	1.1	1.9	3.6	-1.5	1.2	1.8	1.9	0.5	0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.6	0.3	-0.3	-0.2	-1.6	-1.2	-0.7
Glaucoma (self-reported)	0.7	0.8	2.4	-0.5	-1.4	-1.6	0.0	0.4	-0.1
Gout (self-reported)	0.8	1.1	4.8	-0.3	-0.6	2.2	0.2	-1.2	-0.0
Hypothyroidism/myxoedema (self-reported)	2.8	5.4	11.8	-3.0	-0.4	1.1	3.1	1.0	3.4
Medication: Amlodipine	1.3	1.8	4.0	-0.8	1.2	0.1	2.0	2.0	1.1
Medication: Ventolin 100micrograms inhaler	2.5	3.3	6.0	2.5	-1.1	-1.7	-2.1	-0.9	-2.1
Birth weight	0.4	1.0	2.6	-0.5	1.2	1.6	0.9	-0.6	0.5
Chronic bronchitis/emphysema (mother)	2.0	2.4	4.7	-0.9	1.8	0.6	2.2	1.2	1.9
High blood pressure (siblings)	0.8	1.2	2.6	-0.7	0.9	-1.3	1.3	1.6	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.2	0.5	0.7	0.5	0.4	0.0	-0.5	-0.3
Body fat percentage	1.9	7.3	9.6	2.6	-3.0	-3.1	-2.8	-1.6	-2.7
Leg fat percentage (right)	2.2	8.0	11.2	2.8	-2.7	-3.1	-3.4	-2.1	-2.8
Arm fat-free mass (right)	0.1	0.4	1.0	-0.3	0.9	-1.0	0.0	-0.2	-0.6
Exposure to tobacco smoke outside home	0.6	0.8	3.1	-0.0	0.5	0.1	1.8	1.0	0.5
Comparative body size at age 10	1.3	3.5	7.1	-1.5	1.3	1.6	2.1	1.7	2.7
Number of full brothers	0.3	0.4	1.0	0.6	-0.7	-1.0	-0.6	-0.3	-0.6
Worry too long after embarrassment	1.1	1.9	4.5	-2.1	-0.3	1.2	1.7	-0.5	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	3.1	0.0	-1.2	1.2	-0.8	-1.8	0.1
Wheeze or whistling in the chest in last year	1.2	2.2	5.7	2.4	-1.1	-0.5	-0.7	-1.9	-1.3
Number of children fathered	0.9	1.0	3.5	0.3	-0.1	-1.9	-0.7	0.2	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	3.6	-1.3	0.6	0.5	1.9	1.5	1.2
Age at first live birth	0.2	0.4	1.3	0.3	-0.3	-1.0	-0.3	1.1	0.2
Pulse wave peak to peak time	0.4	0.4	1.4	-0.0	0.9	1.2	0.4	0.4	-0.3
Health satisfaction	4.8	6.3	11.5	-2.0	2.7	2.3	3.4	1.9	2.5
Shortness of breath walking on level ground	0.5	0.7	1.5	0.9	1.2	0.7	0.8	-0.4	0.4
Qualifications: College or University degree	0.5	1.7	4.3	0.4	-1.6	-1.5	-2.1	0.5	-0.6
Eye problems/disorders: None of the above	0.4	0.5	1.9	0.4	0.7	1.4	-0.5	-0.4	-0.4
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.2	-0.7	0.3	-0.5	1.8	1.7	1.2
Emphysema/chronic bronchitis	0.5	0.6	2.4	0.3	0.3	0.7	-0.3	-1.5	-0.7
Medication for pain relief, constipation, heartburn	1.2	2.1	3.6	0.8	-0.7	-1.5	-1.9	-1.6	-1.9
Neck or shoulder pain in last month	0.9	1.3	1.9	-1.4	1.1	-0.2	1.4	1.3	1.0
Medication: Blood pressure	0.6	1.1	2.7	-0.1	0.5	1.6	1.6	0.6	0.9
Angina (self-reported)	0.5	0.7	1.5	1.0	-1.2	-0.3	-1.0	-0.8	-0.1
Migraine (self-reported)	1.3	1.7	3.3	-0.4	1.6	1.8	1.6	0.7	0.9
Medication: Ibuprofen	1.3	1.6	3.7	-1.9	0.7	1.3	0.9	1.2	1.2
Medication: Allopurinol	0.6	0.8	1.6	0.5	-0.5	1.2	-0.7	-1.3	-1.0
Medication: Omeprazole	1.2	1.5	2.9	0.9	-1.3	-0.2	-1.7	-1.6	-1.0
Medication: Seretide 50 evohaler	0.5	0.6	1.2	-0.5	-0.8	-1.1	0.8	0.6	0.5
Mean time to correctly identify matches	0.2	0.3	0.9	-0.9	-0.0	0.2	0.3	-1.0	0.1
Heart disease (mother)	0.3	0.3	0.6	0.8	0.6	-0.6	-0.2	0.8	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	4.9	-0.9	1.3	2.2	1.4	0.3	1.3
Whole body fat mass	1.4	5.7	7.6	2.3	-2.3	-2.8	-2.5	-1.6	-2.6
Leg fat mass (right)	1.5	5.6	7.4	2.1	-2.2	-2.7	-2.7	-1.8	-2.6
Arm predicted mass (right)	0.1	0.4	0.9	-0.3	0.8	-0.9	-0.1	-0.5	-0.5
Pulse rate, automated reading	0.4	1.2	4.5	0.3	-2.1	-0.4	-1.2	-0.8	-0.8
Alcohol intake frequency.	0.7	1.6	3.4	1.7	0.6	-0.2	-1.9	-1.0	-1.4
Comparative height size at age 10	0.6	3.5	5.3	2.3	-1.6	-0.9	-2.1	-2.0	-2.0
Number of full sisters	0.5	0.6	1.5	1.0	0.4	-0.4	-0.4	-0.7	-1.2
Suffer from ‘nerves’	1.7	2.6	5.6	-1.3	1.5	1.7	2.4	1.0	1.6
Overall health rating	1.1	2.4	4.1	-0.9	1.6	1.8	2.0	0.3	2.0
Chest pain or discomfort	2.1	3.0	5.4	1.9	-1.1	-0.3	-1.6	-2.3	-2.3
Had major operations	3.2	3.7	6.4	2.1	-0.4	-0.5	-2.3	-2.5	-2.5
Age at last live birth	0.5	0.8	2.0	-1.4	-0.0	-0.7	-0.0	1.2	0.8
Family relationship satisfaction	0.3	0.3	1.3	1.1	-0.7	-0.3	0.1	0.3	0.2
Leg pain on walking	0.6	0.8	2.2	1.2	1.5	0.9	-0.0	-0.5	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.6	-0.1	0.5	0.4	1.3	1.1	0.7
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.9	0.7	0.5	1.4	-0.6	-0.8	-0.4
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.3	0.2	-0.0	-0.5	0.2	0.4
Medication: Aspirin	0.4	0.6	2.5	1.6	0.2	-0.1	-0.1	0.7	-0.6
Supplements: Vitamin C	0.4	0.4	1.8	-0.0	-0.1	-1.3	0.3	-0.4	-0.7
Knee pain experienced in last month	0.5	0.7	2.6	-0.9	1.6	0.4	-0.5	-0.7	-0.4
Hypertension (Self-reported)	0.3	0.9	2.5	-0.1	0.1	0.3	1.5	1.6	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.7	3.2	5.8	1.7	-0.8	-1.1	-2.4	-1.7	-2.4
Illnesses of father: Heart disease	0.1	0.2	0.3	0.4	0.6	0.2	-0.0	0.5	0.5
Illnesses of siblings: Diabetes	1.4	1.7	5.0	0.1	-0.5	-2.2	0.7	2.1	0.5
Smoking status: Previous	0.5	0.8	2.3	-0.0	-1.5	-0.9	-0.0	-1.0	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.2	0.1	0.3	-0.3	0.4	-0.2	-0.4
Whole body fat-free mass	0.1	0.3	1.1	-0.5	1.1	-0.5	0.2	-0.1	-0.3
Leg fat-free mass (right)	0.1	0.3	1.0	-0.7	1.0	-0.5	0.4	0.2	-0.1
Arm fat percentage (left)	1.2	4.9	8.2	2.1	-2.9	-2.0	-2.6	-1.7	-1.9
Average weekly red wine intake	0.3	0.4	1.3	-0.4	-0.6	0.7	0.2	-1.1	-0.1
Handedness (chirality/laterality): Left-handed	1.1	1.4	3.1	0.2	1.5	-0.5	1.8	1.6	0.2
Mood swings	1.1	2.1	4.7	-1.8	-0.1	0.7	2.0	0.3	2.2
Loneliness, isolation	1.0	1.4	4.7	-0.0	0.1	2.2	0.5	-1.1	1.4
Long-standing illness, disability or infirmity	0.3	0.5	1.8	0.5	0.6	0.5	0.1	-1.3	-0.2
Ever had bowel cancer screening	0.4	0.5	1.7	0.6	-0.1	0.0	-0.6	-1.3	-0.9
Diabetes diagnosed by doctor	0.9	1.4	3.8	0.0	-0.8	1.0	2.0	0.8	1.6
Ever had stillbirth, spontaneous miscarriage or termination	3.4	3.7	6.8	1.0	-2.6	-2.3	-1.7	-1.7	-1.9
Friendships satisfaction	0.4	0.5	1.7	0.8	-1.3	-0.5	-0.1	-0.6	0.3
Qualifications: nursing, teaching	2.0	3.0	5.0	1.8	-1.9	-1.3	-2.2	-0.6	-2.1
Commuting to job workplace: Walk	0.7	0.7	1.4	-1.2	0.7	-0.2	0.9	1.2	0.4
Eye problems/disorders: Cataract	0.8	0.9	2.1	-1.3	-0.0	0.1	1.4	1.1	0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.0	0.9	-0.5	-0.5	-1.4	-0.1	-1.2
Medication for cholesterol	0.1	0.1	0.5	-0.4	-0.7	-0.1	-0.1	-0.3	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.0	-0.3	0.5	0.3	0.9	0.3	1.0
Back pain experienced in last month	5.9	8.6	16.6	-1.7	4.1	3.0	3.4	1.9	2.8
Mineral and other dietary supplements	0.3	0.3	1.4	0.2	-0.2	0.5	-0.5	-1.2	-0.4
Breast cancer (self-reported)	1.9	2.3	3.7	-1.9	1.7	-0.9	1.4	1.7	1.3
Asthma (self-reported)	5.2	10.3	19.0	4.4	-3.1	-2.1	-2.9	-2.9	-3.5
Osteoporosis (self-reported)	7.8	9.7	21.6	2.6	-1.4	-1.9	-4.6	-3.0	-4.0
Osteoarthritis (self-reported)	1.3	1.7	9.7	-0.6	3.1	-0.5	0.2	0.1	-0.2
Medication: Aspirin	0.5	0.6	2.9	1.7	-0.1	-0.3	0.0	0.7	-0.6
Medication: Gliclazide	2.5	2.9	4.5	-1.4	1.4	1.1	2.0	2.1	1.9
Illnesses of father: None of the above (group 1)	1.5	1.9	3.2	1.3	-0.9	-0.5	-1.6	-1.7	-1.8
Smoking status: Current	0.2	0.4	1.8	0.4	1.3	0.2	0.1	0.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.6	0.3	-0.4	-0.2	-0.8	-0.0	-0.0
Whole body water mass	0.1	0.3	1.1	-0.4	1.1	-0.5	0.1	-0.2	-0.4
Leg predicted mass (right)	0.1	0.3	0.9	-0.7	1.0	-0.5	0.4	0.2	-0.1
Arm fat mass (left)	1.0	3.9	5.2	1.8	-2.1	-1.9	-2.3	-1.7	-2.1
Number of self-reported non-cancer illnesses	0.5	0.8	2.9	-0.2	0.8	0.3	1.7	0.9	0.6
Average weekly champagne plus white wine intake	0.6	0.8	3.1	-0.5	-0.2	-1.8	-0.6	0.9	-0.2
Miserableness	0.6	1.1	2.6	-0.8	-0.5	0.9	1.6	0.6	1.4
Guilty feelings	0.3	0.5	2.2	0.2	0.3	0.3	1.5	0.6	0.1
Wears glasses or contact lenses	1.2	1.4	3.5	0.6	-0.9	-0.8	-1.1	-1.9	-1.4
Ever taken oral contraceptive pill	0.3	0.3	0.7	0.1	-0.9	-0.7	0.5	-0.7	0.2
Hearing aid user	1.7	1.9	3.0	1.7	0.2	1.1	-1.7	-1.6	-1.4
Mother’s age at death	0.6	0.7	1.8	-1.1	-1.3	-0.1	-0.7	-0.1	0.9
Financial situation satisfaction	0.9	1.1	4.2	-0.3	2.1	0.8	1.1	0.2	-0.3
Tinnitus: Yes, now most or all of the time	2.3	2.7	8.4	-1.2	0.3	2.0	1.2	0.7	2.9
Commuting to job workplace: Public transport	0.8	1.0	2.3	1.1	-0.9	-1.5	-0.5	0.6	-1.0
Eye problems/disorders: Glaucoma	0.3	0.4	0.8	-0.7	-0.8	-0.9	0.4	0.3	-0.1
Medication: Blood pressure	0.3	0.6	2.1	0.6	-0.3	-0.9	0.4	1.4	-0.1
Pain type(s) experienced in last month: Hip pain	0.9	1.2	3.3	1.8	1.4	-0.3	-0.9	-0.8	-0.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.7	-0.6	-0.1	-1.1	0.8	1.6	0.6
High cholesterol (Self-reported)	0.2	0.3	0.8	0.9	-0.4	-0.1	0.6	-0.7	-0.5
Medication: Bendroflumethiazide	0.4	0.6	1.2	0.2	-0.8	-0.8	-0.8	0.6	-1.1
Medication: Paracetamol	2.6	4.0	8.2	-1.6	0.9	1.9	2.9	1.4	2.6
Medication: Lisinopril	0.3	0.4	1.0	0.6	-0.3	0.2	-0.5	-1.0	-1.0
Medication: Atorvastatin	1.2	1.5	2.9	1.2	-1.3	-1.7	-0.8	-0.7	-1.3
Illnesses of father: High blood pressure	1.3	1.6	2.3	-1.1	1.2	1.4	1.2	1.5	1.1
Alcohol drinker status: Never	0.3	0.4	1.0	-1.0	0.4	0.3	-0.8	0.6	-0.0
Ever smoked	0.6	1.1	2.8	-1.1	0.8	0.7	1.7	0.5	1.2
Basal metabolic rate	0.1	0.3	0.7	0.0	0.6	-0.9	-0.3	-0.4	-0.7
Leg fat percentage (left)	1.7	6.3	9.9	2.6	-2.4	-3.1	-2.9	-1.5	-2.3
Arm fat-free mass (left)	0.1	0.5	1.5	-0.5	1.2	-1.0	-0.0	0.0	-0.6
Number of operations (self-reported)	0.6	0.9	2.1	0.3	1.5	-0.8	1.0	1.2	0.2
Average weekly beer plus cider intake	2.4	3.5	9.6	2.2	0.1	-1.3	-0.7	-2.0	-3.1
Irritability	0.1	0.2	0.6	0.5	-0.5	-0.1	0.8	-0.3	-0.1
Risk taking	1.9	2.8	5.7	1.6	-0.5	0.6	-1.5	-2.4	-2.3
Ever had prostate specific antigen (PSA) test	0.6	0.6	2.0	-0.5	-0.5	-1.4	0.6	0.9	0.5
Fractured/broken bones in last 5 years	1.7	2.2	6.1	-2.5	1.3	0.2	0.9	1.7	1.3
Age started oral contraceptive pill	0.7	0.8	2.5	-0.6	-1.6	-1.2	-0.7	-0.1	-0.5
Diastolic blood pressure, automated reading	0.1	0.3	0.9	-0.5	-0.2	-0.9	-0.2	0.3	-0.7
Ever depressed for a whole week	0.4	0.5	1.2	0.1	-0.8	-0.6	-0.3	-1.1	-1.0
Unable to work because of sickness or disability	0.4	0.5	1.3	-0.3	1.0	0.7	0.3	-1.1	-0.4
Commuting to job workplace: Cycle	0.4	0.5	0.9	-0.8	-1.0	-0.3	0.7	0.6	0.9
Myopia	0.1	0.2	0.7	0.1	-0.3	-0.3	-0.2	-0.9	-0.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.6	-0.7	0.6	0.0	-0.7	-0.8	-0.2
Cholesterol lowering medication	0.2	0.3	1.2	1.1	-0.2	-0.6	-0.3	-0.1	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.2	1.0	-1.1	-0.5	-1.4	-1.5	-0.6
Pain experienced in last month	1.1	1.9	9.1	0.6	-3.0	-0.9	-0.9	-0.1	0.1
Supplements: Calcium	5.5	6.0	9.9	2.3	-1.7	0.2	-2.9	-3.1	-3.1
Basal cell carcinoma (self-reported)	0.8	1.0	3.0	0.6	-0.0	1.1	-0.8	-1.7	-0.6
Heart attack/myocardial infarction (self-reported)	1.3	1.6	3.9	1.4	-0.8	0.2	-2.0	-1.6	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.7	-0.4	0.6	-1.3	-0.8	-0.0	-0.6
Heart disease (siblings)	1.2	1.5	3.0	1.6	-0.5	-1.7	0.0	-0.4	-1.7
Alcohol drinker status: Previous	0.6	0.7	2.2	0.2	1.0	1.5	-0.1	-1.0	-0.3
Pack years of smoking	0.3	0.4	1.1	0.2	1.0	-0.2	0.6	0.9	0.5
Impedance of whole body	0.3	1.5	4.6	1.7	-2.1	-0.5	-0.8	-0.1	-1.0
Leg fat mass (left)	1.2	4.7	7.4	1.9	-1.9	-2.7	-2.4	-1.4	-2.3
Arm predicted mass (left)	0.1	0.6	1.7	-0.4	1.3	-1.1	-0.2	-0.1	-0.8