Best TWAS P=3.44e-15 · Best GWAS P=3.17e-15 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RMI1 | 0.07 | 0.06 | lasso | 3 | 0.06 | 1.4e-07 | 7.6 | -7.6 | 2.8e-14 | -0.98 | 0.01 | 0.99 | FALSE |
2 | GTEx | Esophagus Mucosa | GKAP1 | 0.09 | 0.06 | lasso | 2 | 0.02 | 2.9e-02 | 7.0 | -7.0 | 2.5e-12 | -0.68 | 0.31 | 0.47 | FALSE |
3 | GTEx | Muscle Skeletal | GKAP1 | 0.07 | 0.04 | enet | 23 | 0.03 | 1.0e-03 | 7.0 | -5.7 | 9.6e-09 | -0.50 | 0.40 | 0.30 | FALSE |
4 | YFS | Blood | GKAP1 | 0.02 | 0.01 | blup | 614 | 0.01 | 3.2e-04 | 7.3 | -7.2 | 4.3e-13 | -0.70 | 0.01 | 0.98 | FALSE |
5 | YFS | Blood | RMI1 | 0.07 | 0.09 | bslmm | 528 | 0.09 | 1.5e-27 | 7.3 | 7.9 | 3.4e-15 | 0.95 | 0.03 | 0.97 | TRUE |
6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | UBQLN1 | 0.03 | 0.02 | lasso | 2 | 0.01 | 2.3e-02 | 5.4 | -6.2 | 5.3e-10 | -0.55 | 0.07 | 0.12 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RMI1 | 0.02 | 0.02 | blup | 31 | 0.01 | 8.8e-04 | 7.5 | -6.1 | 8.8e-10 | -0.93 | 0.01 | 0.92 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RMI1 | 0.03 | 0.03 | lasso | 4 | 0.04 | 4.1e-05 | 7.4 | -6.1 | 8.4e-10 | -0.92 | 0.01 | 0.96 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RMI1 | 0.03 | 0.03 | blup | 31 | 0.01 | 1.2e-02 | 7.7 | -7.1 | 1.6e-12 | -0.97 | 0.01 | 0.97 | FALSE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | UBQLN1 | 0.13 | 0.09 | blup | 60 | 0.10 | 4.9e-05 | -2.7 | -5.2 | 2.3e-07 | -0.31 | 0.27 | 0.04 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | GKAP1 | 0.05 | 0.06 | lasso | 3 | 0.06 | 1.2e-06 | 7.0 | -7.0 | 2.0e-12 | -0.73 | 0.39 | 0.60 | FALSE |