[Hub]/) : Traits : Blood Eosinophil Count : ← →

chr9:138,525,778-140,642,331

Best TWAS P=1.27e-20 · Best GWAS P=1.74e-20 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	INPP5E	0.18	0.14	enet	21	0.21	1.6e-24	9.2	-9.1	1.2e-19	-0.89	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SNAPC4	0.06	0.04	lasso	2	0.05	9.0e-07	4.8	-5.8	9.1e-09	-0.67	0.95	0.01	FALSE
3	GTEx	Adipose Subcutaneous	SDCCAG3	0.13	0.00	enet	21	0.04	4.8e-04	7.6	-6.3	3.8e-10	-0.48	0.17	0.18	FALSE
4	GTEx	Brain Caudate basal ganglia	INPP5E	0.23	0.20	enet	8	0.22	7.2e-07	7.8	-6.6	5.1e-11	-0.62	0.29	0.54	FALSE
5	GTEx	Brain Cerebellar Hemisphere	INPP5E	0.25	0.23	enet	6	0.17	3.4e-05	7.7	-7.3	2.0e-13	-0.68	0.52	0.24	FALSE
6	GTEx	Brain Cerebellar Hemisphere	GPSM1	0.26	0.07	lasso	4	0.11	9.6e-04	4.3	-8.5	1.3e-17	-0.70	0.01	0.90	FALSE
7	GTEx	Brain Cerebellum	INPP5E	0.40	0.30	enet	20	0.29	3.6e-09	7.8	-7.0	2.9e-12	-0.63	0.98	0.01	FALSE
8	GTEx	Brain Putamen basal ganglia	INPP5E	0.28	0.20	enet	6	0.01	2.2e-01	5.9	-5.8	8.4e-09	-0.59	0.29	0.14	FALSE
9	GTEx	Cells Transformed fibroblasts	SDCCAG3	0.12	0.03	enet	21	0.06	5.4e-05	7.6	-8.0	1.8e-15	-0.80	0.46	0.53	FALSE
10	GTEx	Colon Transverse	SEC16A	0.13	0.04	lasso	4	0.05	2.5e-03	7.4	-5.2	2.0e-07	-0.35	0.15	0.10	FALSE
11	GTEx	Colon Transverse	SDCCAG3	0.11	0.01	lasso	8	0.02	5.5e-02	7.6	-8.2	1.7e-16	-0.74	0.01	0.95	FALSE
12	GTEx	Esophagus Mucosa	INPP5E	0.11	0.12	lasso	3	0.12	1.0e-08	7.7	-7.5	8.5e-14	-0.67	0.96	0.04	FALSE
13	GTEx	Esophagus Mucosa	SDCCAG3	0.09	0.02	lasso	2	0.02	2.6e-02	6.1	-5.6	2.0e-08	-0.56	0.12	0.20	FALSE
14	GTEx	Esophagus Muscularis	SDCCAG3	0.10	0.02	enet	5	0.02	3.6e-02	5.6	-7.6	3.4e-14	-0.59	0.04	0.86	FALSE
15	GTEx	Heart Atrial Appendage	INPP5E	0.13	0.12	lasso	2	0.10	3.5e-05	7.4	-7.4	1.3e-13	-0.71	0.21	0.36	FALSE
16	GTEx	Liver	PMPCA	0.31	0.00	lasso	5	0.06	8.9e-03	-1.7	5.4	6.7e-08	0.50	0.04	0.60	FALSE
17	GTEx	Lung	INPP5E	0.10	0.05	enet	13	0.04	6.1e-04	7.8	-7.2	8.7e-13	-0.65	0.72	0.06	FALSE
18	GTEx	Lung	CARD9	0.08	0.04	enet	6	0.04	2.5e-04	3.8	5.8	8.8e-09	0.59	0.83	0.07	FALSE
19	GTEx	Nerve Tibial	INPP5E	0.13	0.17	enet	10	0.14	3.7e-10	7.8	-7.6	3.6e-14	-0.64	1.00	0.00	FALSE
20	GTEx	Ovary	INPP5E	0.24	0.13	enet	11	0.15	1.9e-04	5.7	-5.5	3.6e-08	-0.59	0.12	0.29	FALSE
21	GTEx	Pancreas	SEC16A	0.28	0.10	enet	16	0.16	4.1e-07	7.4	-7.6	3.0e-14	-0.67	0.13	0.86	FALSE
22	GTEx	Pancreas	SDCCAG3	0.21	0.03	lasso	4	0.01	9.5e-02	6.1	-5.9	3.8e-09	-0.68	0.04	0.65	FALSE
23	GTEx	Pituitary	INPP5E	0.21	0.24	lasso	3	0.14	1.8e-04	7.8	7.6	2.5e-14	0.68	0.26	0.12	FALSE
24	GTEx	Skin Sun Exposed Lower leg	INPP5E	0.10	0.10	lasso	2	0.09	5.2e-08	7.7	-7.1	1.2e-12	-0.66	0.82	0.18	FALSE
25	GTEx	Skin Sun Exposed Lower leg	SDCCAG3	0.16	0.08	lasso	4	0.07	1.0e-06	6.1	-6.5	1.0e-10	-0.70	0.62	0.20	FALSE
26	GTEx	Spleen	PMPCA	0.24	0.15	lasso	2	0.10	1.7e-03	7.4	7.0	1.8e-12	0.71	0.03	0.58	FALSE
27	GTEx	Stomach	SEC16A	0.15	0.09	lasso	4	0.10	1.8e-05	7.4	-7.2	8.5e-13	-0.69	0.32	0.63	FALSE
28	GTEx	Stomach	SDCCAG3	0.24	0.07	lasso	4	0.05	1.9e-03	-5.5	-7.0	3.4e-12	-0.69	0.04	0.83	FALSE
29	GTEx	Testis	INPP5E	0.24	0.32	enet	10	0.30	5.4e-14	7.8	-7.1	1.2e-12	-0.68	0.99	0.01	FALSE
30	GTEx	Testis	SDCCAG3	0.15	0.09	lasso	4	0.13	3.3e-06	7.6	-8.2	2.7e-16	-0.84	0.09	0.89	FALSE
31	GTEx	Thyroid	INPP5E	0.23	0.35	enet	16	0.37	8.2e-30	6.0	-7.6	2.9e-14	-0.74	1.00	0.00	FALSE
32	GTEx	Thyroid	SDCCAG3	0.16	0.11	lasso	3	0.12	9.4e-10	7.6	-7.0	3.2e-12	-0.78	0.99	0.01	FALSE
33	GTEx	Uterus	INPP5E	0.60	0.04	enet	10	0.22	3.4e-05	7.6	-5.5	4.8e-08	-0.53	0.08	0.26	FALSE
34	GTEx	Whole Blood	ENTPD2	0.11	0.03	enet	31	0.05	1.1e-05	4.2	-5.2	1.7e-07	-0.07	0.02	0.58	TRUE
35	GTEx	Whole Blood	SEC16A	0.07	0.05	lasso	5	0.04	1.3e-04	7.4	-7.2	4.7e-13	-0.72	0.08	0.92	FALSE
36	GTEx	Whole Blood	SDCCAG3	0.07	0.03	enet	6	0.02	3.4e-03	6.9	-6.8	7.3e-12	-0.79	0.09	0.88	FALSE
37	METSIM	Adipose	SDCCAG3	0.08	0.04	bslmm	357	0.05	3.9e-08	7.6	-5.9	3.4e-09	-0.72	0.02	0.98	FALSE
38	YFS	Blood	CARD9	0.22	0.37	lasso	5	0.39	1.3e-137	4.7	5.9	3.9e-09	0.64	1.00	0.00	FALSE
39	YFS	Blood	INPP5E	0.33	0.55	lasso	6	0.57	2.9e-235	7.6	-7.6	2.5e-14	-0.70	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	SDCCAG3	0.05	0.01	blup	61	0.01	7.9e-04	7.4	-5.6	2.0e-08	-0.61	0.07	0.17	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEC16A	0.02	0.00	blup	69	0.01	1.0e-03	7.8	-6.4	1.2e-10	-0.75	0.03	0.84	FALSE
42	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	INPP5E	0.25	0.10	lasso	3	0.09	4.9e-05	7.6	-8.0	1.9e-15	-0.73	0.06	0.85	FALSE
43	The Cancer Genome Atlas	Colon Adenocarcinoma	INPP5E	0.11	0.08	lasso	2	0.08	3.4e-05	7.6	-7.9	3.7e-15	-0.72	0.02	0.85	FALSE
44	The Cancer Genome Atlas	Colon Adenocarcinoma	SDCCAG3	0.08	0.01	lasso	4	0.02	3.1e-02	6.1	-7.9	2.4e-15	-0.79	0.03	0.50	FALSE
45	The Cancer Genome Atlas	Colon Adenocarcinoma	SNAPC4	0.15	0.03	enet	12	0.05	1.0e-03	6.0	-5.7	9.4e-09	-0.43	0.07	0.08	FALSE
46	The Cancer Genome Atlas	Esophageal Carcinoma	DNLZ	0.64	0.25	blup	43	0.34	1.8e-11	-3.8	-5.2	2.6e-07	-0.36	0.47	0.48	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SDCCAG3	0.04	0.05	enet	6	0.04	5.1e-05	6.1	-6.4	1.5e-10	-0.74	0.33	0.63	FALSE
48	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INPP5E	0.07	0.04	blup	54	0.07	6.0e-05	9.1	-7.9	2.7e-15	-0.84	0.01	0.96	FALSE
49	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SDCCAG3	0.05	0.01	blup	61	0.01	5.9e-02	9.2	-7.2	4.6e-13	-0.81	0.01	0.90	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	SDCCAG3	0.08	0.05	lasso	2	0.05	3.3e-06	6.1	-6.1	1.1e-09	-0.71	0.41	0.54	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEC16A	0.08	0.10	lasso	4	0.08	1.9e-08	9.3	-9.3	1.3e-20	-0.98	0.00	1.00	TRUE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	SNAPC4	0.16	0.02	blup	60	0.03	4.9e-04	5.3	-5.3	1.4e-07	-0.48	0.08	0.42	FALSE
53	The Cancer Genome Atlas	Testicular Germ Cell Tumors	INPP5E	0.10	0.06	blup	54	0.08	8.1e-04	7.7	-8.2	2.0e-16	-0.82	0.05	0.58	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	INPP5E	0.11	0.16	lasso	3	0.16	2.4e-15	5.7	-6.6	4.5e-11	-0.70	0.99	0.01	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	SDCCAG3	0.16	0.14	lasso	4	0.12	8.2e-12	6.1	-6.3	3.4e-10	-0.71	1.00	0.00	FALSE