Best TWAS P=5.59e-35 · Best GWAS P=3.39e-47 conditioned to 2.61e-11
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | IDI2 | 0.16 | 0.19 | bslmm | 511 | 0.20 | 2.5e-23 | 6.7 | -8.2 | 2.2e-16 | -0.55 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | IDI2-AS1 | 0.07 | 0.00 | blup | 523 | 0.03 | 2.6e-04 | -5.3 | 5.6 | 2.5e-08 | 0.37 | 0.47 | 0.04 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | WDR37 | 0.07 | 0.03 | bslmm | 606 | 0.05 | 2.9e-06 | -5.3 | -5.4 | 8.5e-08 | -0.35 | 0.96 | 0.00 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | WDR37 | 0.15 | 0.04 | lasso | 3 | 0.03 | 9.3e-04 | 10.1 | 9.8 | 1.6e-22 | 0.63 | 0.89 | 0.04 | FALSE |
| 5 | GTEx | Adipose Subcutaneous | GTPBP4 | 0.11 | 0.05 | enet | 40 | 0.04 | 1.7e-04 | -1.9 | -6.9 | 5.8e-12 | -0.29 | 0.55 | 0.31 | FALSE |
| 6 | GTEx | Adipose Visceral Omentum | GTPBP4 | 0.17 | -0.01 | lasso | 4 | 0.00 | 4.5e-01 | -3.7 | -5.7 | 9.9e-09 | -0.32 | 0.06 | 0.28 | FALSE |
| 7 | GTEx | Adrenal Gland | LARP4B | 0.21 | 0.09 | lasso | 6 | 0.11 | 6.8e-05 | -4.6 | -9.6 | 6.8e-22 | -0.60 | 0.20 | 0.50 | FALSE |
| 8 | GTEx | Breast Mammary Tissue | WDR37 | 0.17 | 0.03 | lasso | 5 | 0.02 | 4.5e-02 | -2.1 | 5.5 | 3.4e-08 | 0.35 | 0.20 | 0.13 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | GTPBP4 | 0.12 | 0.04 | enet | 27 | 0.07 | 3.2e-06 | 12.4 | -10.1 | 4.2e-24 | -0.59 | 0.04 | 0.92 | TRUE |
| 10 | GTEx | Colon Transverse | IDI1 | 0.14 | 0.00 | lasso | 4 | -0.01 | 9.2e-01 | 11.6 | 12.3 | 5.6e-35 | 0.83 | 0.04 | 0.81 | TRUE |
| 11 | GTEx | Lung | DIP2C | 0.07 | 0.01 | enet | 15 | 0.02 | 6.4e-03 | -5.8 | 5.6 | 2.6e-08 | 0.46 | 0.05 | 0.52 | FALSE |
| 12 | GTEx | Nerve Tibial | WDR37 | 0.31 | 0.20 | lasso | 8 | 0.25 | 1.3e-17 | 10.4 | 10.4 | 1.6e-25 | 0.67 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Pancreas | WDR37 | 0.17 | 0.14 | lasso | 2 | 0.09 | 8.9e-05 | 10.4 | 10.1 | 5.2e-24 | 0.66 | 0.39 | 0.26 | FALSE |
| 14 | YFS | Blood | LARP4B | 0.04 | 0.01 | enet | 26 | 0.02 | 9.7e-07 | 6.3 | -10.1 | 3.6e-24 | -0.68 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IDI2 | 0.08 | 0.02 | blup | 54 | 0.03 | 5.7e-04 | 6.7 | -7.6 | 2.6e-14 | -0.51 | 0.02 | 0.57 | FALSE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IDI2 | 0.06 | 0.07 | enet | 8 | 0.07 | 2.5e-14 | 6.7 | -5.5 | 3.2e-08 | -0.38 | 1.00 | 0.00 | FALSE |
| 17 | The Cancer Genome Atlas | Colon Adenocarcinoma | IDI2 | 0.15 | 0.12 | enet | 10 | 0.14 | 3.1e-08 | 6.7 | -8.6 | 7.0e-18 | -0.58 | 0.48 | 0.49 | FALSE |
| 18 | The Cancer Genome Atlas | Glioblastoma Multiforme | IDI2 | 0.15 | 0.11 | enet | 10 | 0.08 | 1.7e-03 | 6.7 | -7.9 | 2.3e-15 | -0.56 | 0.04 | 0.52 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IDI2 | 0.16 | 0.13 | enet | 10 | 0.13 | 2.4e-14 | 6.6 | -7.1 | 1.3e-12 | -0.46 | 1.00 | 0.00 | FALSE |
| 20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C10orf110 | 0.07 | 0.07 | lasso | 3 | 0.07 | 3.3e-08 | 10.4 | 10.8 | 4.7e-27 | 0.68 | 0.02 | 0.98 | FALSE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | IDI2 | 0.10 | 0.12 | lasso | 7 | 0.10 | 6.6e-12 | 6.7 | -6.0 | 1.5e-09 | -0.41 | 1.00 | 0.00 | FALSE |
| 22 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | IDI2 | 0.31 | 0.17 | enet | 9 | 0.24 | 7.7e-10 | 6.7 | -6.0 | 2.5e-09 | -0.38 | 0.73 | 0.20 | FALSE |
| 23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IDI2 | 0.13 | 0.14 | enet | 12 | 0.15 | 1.0e-15 | 6.7 | -6.9 | 5.0e-12 | -0.48 | 1.00 | 0.00 | FALSE |
| 24 | The Cancer Genome Atlas | Stomach Adenocarcinoma | IDI2 | 0.07 | 0.01 | enet | 13 | 0.03 | 2.5e-03 | 6.7 | -8.2 | 1.8e-16 | -0.58 | 0.03 | 0.72 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | IDI2 | 0.15 | 0.17 | enet | 8 | 0.19 | 8.7e-18 | 6.6 | -6.0 | 1.5e-09 | -0.42 | 1.00 | 0.00 | FALSE |