TWAS hub - CELF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.0810	0.0383	0.0012	0.020	NA	0.060	NA	0.035	1.3e-02	NA	4.3e-05	NA	0.00170
2	GTEx	Prostate	0.1750	0.0820	0.0060	0.159	NA	0.103	NA	0.121	8.6e-05	NA	1.5e-03	NA	0.00062
3	ROSMAP	Brain Pre-frontal Cortex	0.0275	0.0173	0.0150	0.011	0.003	0.004	0.008	0.005	1.1e-02	0.11	9.1e-02	0.029	0.05800

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
HDL Cholesterol	11.3	18.9	35.3	-1.3	4.4	5.9
Systolic Blood Pressure	11.3	56.8	112.4	-10.6	-7.4	-1.8
Depressed Affect (Nagel 2018)	10.9	22.9	39.3	-5.3	-6.3	-0.9
Miserableness	9.8	17.0	28.2	-4.6	-5.3	-1.3
High blood pressure	9.7	27.2	28.2	-5.3	-5.1	-5.2
Heel T-Score	9.5	75.3	219.0	-1.4	14.8	2.2
Fed-up feelings	9.2	16.7	38.4	-3.2	-6.2	-1.3
Hypertension (Self-reported)	9.1	25.2	27.5	-5.2	-4.8	-5.0
Heel bone mineral density (BMD) T-score, automated (right)	8.5	19.5	52.3	0.8	7.2	2.4
Vascular/heart problems diagnosed by doctor	8.0	21.7	24.0	4.6	4.9	4.5
Fasting Glucose	7.6	9.1	10.8	3.2	2.5	3.3
Illnesses of father: High blood pressure	7.5	9.2	21.9	-4.7	-0.3	-2.4
Neuroticism	7.1	17.1	34.2	-4.1	-5.9	0.7
Mean time to correctly identify matches	7.1	13.6	29.6	0.7	5.4	3.3
Heel bone mineral density (BMD) T-score, automated (left)	7.0	15.9	43.4	0.4	6.6	2.0
Neuroticism (Nagel 2018)	6.9	16.3	25.9	-4.8	-5.1	-0.6
Mood swings	6.8	12.4	22.5	-4.7	-3.5	-1.5
Neuroticism score	6.4	13.3	20.7	-4.4	-4.5	0.4
Loneliness, isolation	5.8	8.0	10.2	-2.7	-3.2	2.5
Medication: Bendroflumethiazide	5.7	8.7	13.8	-3.7	-2.4	-2.5
Suffer from ‘nerves’	5.6	8.9	13.1	-3.6	-3.3	1.6
Reaction Time	5.4	10.4	23.6	0.9	4.9	2.6
Systolic blood pressure, automated reading	5.4	15.6	26.3	-4.4	-5.1	-0.9
Arm fat percentage (left)	5.3	21.0	48.6	7.0	-0.9	-3.7
Hearing difficulty/problems with background noise	5.1	8.2	19.2	-1.7	-4.4	-1.6
Guilty feelings	5.1	7.7	16.6	-4.1	-2.4	1.0
Diastolic blood pressure, automated reading	5.0	15.5	27.4	-5.2	-3.4	-2.8
Neuroticism (2016)	4.9	7.1	10.7	-3.3	-3.3	-0.3
Arm fat percentage (right)	4.8	18.9	43.8	6.6	-0.4	-3.5
Standing height	4.8	48.1	132.2	-1.9	2.9	11.5
Forced vital capacity (FVC), Best measure	4.8	17.5	27.4	-2.6	4.3	5.2
High blood pressure (siblings)	4.7	6.7	11.4	-3.4	-0.7	-2.9
Frequency of depressed mood in last 2 weeks	4.6	6.5	11.0	-2.9	-3.3	-0.2
Blood White Count	4.5	33.3	99.0	-0.9	0.2	-9.9
Body Mass Index (BMI) (2010)	4.4	6.0	17.1	4.1	-0.4	-0.9
Trunk fat-free mass	4.4	25.1	65.0	1.3	3.0	8.1
Cardiovascular Disease	4.3	14.3	19.4	-4.4	-3.5	-3.3
Trunk predicted mass	4.3	24.8	64.2	1.3	2.9	8.0
Medication: Blood pressure	4.3	7.6	10.1	-3.2	-3.0	-2.0
Height	4.2	81.8	234.1	-1.2	3.1	15.3
Medication: Blood pressure	4.2	8.0	13.4	-2.6	-2.0	-3.7
Hand grip strength (left)	4.1	10.8	26.4	-5.1	1.3	2.1
Hayfever/allergic rhinitis (self-reported)	4.0	5.3	9.9	-1.2	-3.1	-2.1
Mouth/teeth dental problems: Bleeding gums	4.0	5.2	10.0	-2.1	1.1	-3.2
Eye problems/disorders: Glaucoma	4.0	4.7	11.5	1.0	1.3	3.4
Waist circumference	3.9	14.4	42.3	6.5	-0.9	0.3
Comparative height size at age 10	3.9	21.6	56.1	-0.7	2.9	7.5
Worry (Nagel 2018)	3.8	7.9	18.2	-4.3	-2.3	-0.4
Trunk fat percentage	3.8	15.3	37.7	6.1	-1.0	-2.7
Sitting height	3.8	26.7	53.1	-4.6	2.4	7.3
Frequency of tiredness / lethargy in last 2 weeks	3.8	6.2	11.7	-0.3	-3.4	2.6
Body fat percentage	3.8	15.1	30.5	5.5	-1.2	-3.7
Leg fat-free mass (right)	3.8	20.2	36.0	4.7	1.7	6.0
Whole body water mass	3.8	21.9	52.7	2.7	2.4	7.3
Whole body fat-free mass	3.7	21.2	51.0	2.6	2.4	7.1
Leg predicted mass (right)	3.7	19.9	35.3	4.6	1.8	5.9
Leg fat percentage (left)	3.7	13.2	24.3	3.8	-1.2	-4.9
Depression (Nagel 2018)	3.6	5.5	12.5	-1.8	-3.5	0.8
Alzheimer’s Disease (including proxy)	3.6	5.2	14.1	-3.8	0.9	-0.8
Blood Eosinophil Count	3.6	27.5	55.8	-5.0	1.3	-7.5
Leg fat-free mass (left)	3.6	18.9	32.2	4.6	1.7	5.7
Leg predicted mass (left)	3.6	19.0	31.9	4.7	1.7	5.6
Leg fat percentage (right)	3.5	12.8	24.0	3.6	-1.3	-4.9
Medication: Lisinopril	3.5	4.5	6.2	-2.0	-2.5	-1.8
Severe depression (siblings)	3.4	3.8	7.0	-0.6	2.0	2.6
Impedance of leg (left)	3.4	16.4	37.1	-6.1	-1.0	-3.4
Forced expiratory volume in 1-second (FEV1), predicted	3.4	7.0	14.8	-0.7	2.4	3.8
Impedance of leg (right)	3.3	16.1	37.0	-6.1	-0.9	-3.2
Body mass index (BMI)	3.3	14.0	36.0	6.0	-0.4	-2.4
Forced vital capacity (FVC)	3.3	12.6	21.6	-2.3	3.3	4.7
Arm fat mass (left)	3.3	13.4	39.3	6.3	0.0	-0.9
Average weekly beer plus cider intake	3.3	4.8	6.6	-2.6	1.6	2.2
Ever used hormone-replacement therapy (HRT)	3.2	4.1	5.9	2.4	-2.0	-1.5
Tense / ‘highly strung’	3.2	5.2	11.6	-3.4	-0.9	-1.8
Basal metabolic rate	3.2	17.8	38.1	3.4	2.0	6.2
Blood Platelet Count	3.1	35.6	70.2	-6.0	0.0	8.4
BMI	3.1	18.1	46.6	6.8	-0.2	-2.8
Forced expiratory volume in 1-second (FEV1), Best measure	3.1	9.8	13.8	-1.6	3.6	3.7
Arm fat mass (right)	3.1	12.7	37.1	6.1	0.0	-1.1
Number of self-reported non-cancer illnesses	3.1	5.4	14.0	-1.5	-3.7	0.1
Pulse rate, automated reading	3.0	9.9	18.2	4.3	0.3	3.4
Smoking status: Current	3.0	4.8	11.6	-3.4	-0.4	1.6
Hand grip strength (right)	2.9	8.0	21.5	-4.6	0.2	1.6
Current tobacco smoking	2.9	4.7	11.0	-3.3	-0.4	1.7
Commuting to job workplace: Car/motor vehicle	2.9	3.4	8.8	-0.4	3.0	-1.1
Number of incorrect matches in round	2.8	4.6	11.8	1.4	3.4	-0.3
Ever unenthusiastic/disinterested for a whole week	2.8	3.4	7.1	-0.4	1.7	2.7
Depression (self-reported)	2.8	3.3	8.8	0.2	-1.0	3.0
Breastfed as a baby	2.8	3.4	9.6	-0.1	0.8	3.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	7.8	-1.2	-2.8	1.3
Trunk fat mass	2.7	11.6	34.5	5.9	-0.2	-0.5
Hair/balding pattern: Pattern 4	2.7	6.6	15.2	1.6	-3.9	-1.4
Hip circumference	2.6	11.2	30.4	5.5	-1.7	-0.7
Comparative body size at age 10	2.6	7.1	21.2	4.6	0.0	-0.2
Arm predicted mass (right)	2.6	13.2	35.2	1.6	1.5	5.9
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	8.8	0.5	3.0	-0.6
Primary Biliary Cirrhosis	2.5	3.6	7.3	-1.2	1.4	2.7
Medication: Metformin	2.5	3.5	9.4	3.1	1.0	0.4
Medication: Amlodipine	2.5	3.4	5.2	-1.9	-2.3	-1.2
Arm fat-free mass (right)	2.5	12.8	34.7	1.4	1.3	5.9
Whole body fat mass	2.5	10.5	30.1	5.5	-0.3	-1.1
Arm fat-free mass (left)	2.5	12.6	32.5	1.7	1.6	5.7
Medication: Atenolol	2.4	3.0	5.5	-2.3	1.2	-1.4
Mouth/teeth dental problems	2.4	3.6	5.0	2.2	-1.4	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	7.0	-0.5	-2.0	2.6
Arm predicted mass (left)	2.4	12.3	31.8	1.7	1.5	5.6
Breast Cancer	2.3	5.5	9.3	-3.0	-1.0	-2.5
Angina	2.3	3.0	7.1	-0.2	-1.4	-2.7
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	7.6	-2.8	-1.6	0.6
Weight	2.3	11.3	24.3	4.9	0.7	3.0
Time employed in main current job	2.3	2.7	7.3	-0.6	2.7	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.7	3.9	-1.5	-1.5	-2.0
Alcohol intake frequency.	2.3	5.3	10.3	3.2	1.1	-2.1
Deep venous thrombosis (DVT) (self-reported)	2.3	2.9	4.0	-1.0	2.0	2.0
Nervous feelings	2.2	4.1	8.5	-2.9	-1.7	-0.9
Lung cancer (father)	2.2	2.5	3.0	-1.7	1.6	1.4
Angina (self-reported)	2.2	2.9	7.6	-0.3	-1.1	-2.8
Chest pain or discomfort	2.2	3.1	7.5	-2.7	-0.8	1.1
Myopia	2.2	3.2	7.1	-1.2	0.9	2.7
Waist Hip Ratio (WHR)	2.1	9.5	21.2	2.7	-0.0	4.6
Forced expiratory volume in 1-second (FEV1)	2.1	7.0	9.7	-1.7	2.9	3.1
Glaucoma (self-reported)	2.1	2.5	5.5	0.4	1.3	2.3
Birth weight	2.1	4.5	10.9	-1.5	0.6	3.3
Ever depressed for a whole week	2.1	2.6	6.9	0.6	0.7	2.6
Verbal and Numeric Reasoning (VNR)	2.0	4.9	11.6	-0.9	-1.5	3.4
Triglycerides	2.0	3.2	5.0	0.8	-2.2	-2.0
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	6.4	1.2	-0.1	2.5
Pulse rate	2.0	3.4	5.6	2.4	0.1	2.1
Happiness	2.0	2.4	6.4	0.2	-2.5	0.8
Blood clot in the leg (DVT)	2.0	2.6	4.0	-1.0	1.7	2.0
Leg fat mass (right)	2.0	7.9	20.0	4.5	-0.5	-1.9
Leg pain on walking	2.0	2.5	6.6	-2.6	-0.8	-0.4
Commuting to job workplace: Walk	2.0	2.1	5.6	-0.3	-2.4	0.8
Leg fat mass (left)	2.0	7.9	20.7	4.5	-0.1	-1.7
Alzheimer’s Disease (in mother)	1.9	2.2	3.8	-2.0	1.1	-1.2
Number of treatments/medications taken	1.9	3.4	7.4	1.6	-2.7	-0.3
Townsend deprivation index at recruitment	1.9	2.7	6.2	-0.9	-1.1	2.5
High blood pressure (mother)	1.9	2.6	6.5	-0.9	-2.6	-0.7
Hair/balding pattern: Pattern 2	1.9	2.4	5.2	-2.3	1.1	0.9
Number of children fathered	1.9	2.2	5.7	0.3	2.4	-0.8
Unable to work because of sickness or disability	1.9	2.4	7.1	-0.0	-0.4	2.7
Overall health rating	1.8	3.9	9.8	-0.9	-3.1	1.0
Average weekly champagne plus white wine intake	1.8	2.4	5.5	-2.4	1.3	-0.4
Alcohol drinker status: Never	1.8	2.1	3.9	1.6	-0.1	-2.0
Schizophrenia vs Biploar Disorder	1.7	2.2	3.7	-1.6	1.9	0.7
Schizophrenia (2014)	1.7	3.7	4.2	-2.0	1.7	2.0
Smoking Status	1.7	4.0	5.3	-2.3	1.3	2.3
Illnesses of mother	1.7	2.1	3.5	1.9	1.5	0.8
Knee pain experienced in last month	1.7	2.6	5.7	0.2	1.4	2.4
Osteoarthritis (self-reported)	1.7	2.2	4.5	1.1	-1.0	2.1
Lupus	1.6	2.4	6.3	0.9	-0.4	2.5
Illnesses of father: Heart disease	1.6	2.3	3.3	0.9	-1.8	1.6
Diabetes diagnosed by doctor	1.6	2.6	7.5	2.7	0.4	0.5
Major Depression (MDD)	1.5	1.8	3.2	-0.7	-1.3	1.8
Ever had hysterectomy (womb removed)	1.5	1.6	3.0	1.1	-0.9	-1.7
Hayfever, allergic rhinitis or eczema	1.5	3.2	7.1	-2.7	-0.2	-1.5
Supplements: Glucosamine	1.5	2.0	3.4	1.2	1.8	1.0
Fluid intelligence score	1.5	3.2	5.9	-1.8	-0.6	2.4
Ever had bowel cancer screening	1.5	1.8	3.2	1.8	1.2	-0.7
Qualifications: nursing, teaching	1.5	2.3	3.8	1.7	-1.9	0.4
Osteoporosis (self-reported)	1.5	1.9	5.5	0.2	-2.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	8.1	-0.8	2.8	-0.9
Supplements: Fish oil (including cod liver oil)	1.5	2.0	4.4	2.1	1.0	-0.7
Age when periods started (menarche)	1.4	3.4	10.0	-3.2	0.4	0.2
Alcohol intake versus 10 years previously	1.4	2.1	3.6	1.9	1.5	-0.7
Hair/balding pattern: Pattern 3	1.4	2.0	4.1	2.0	-1.0	-1.0
Number of live births	1.4	2.0	4.1	-2.0	1.3	-0.5
Mouth/teeth dental problems: Loose teeth	1.4	1.7	4.1	-2.0	-0.3	-0.9
Friendships satisfaction	1.4	1.7	2.4	-1.6	-1.4	1.0
Risk taking	1.4	2.1	4.0	0.3	1.4	2.0
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.7	1.0	-1.9	0.4
Intelligence (Savage-Jansen 2018)	1.3	3.9	8.9	-1.4	-0.9	3.0
Bipolar Disorder (2011)	1.3	1.3	2.0	-0.2	1.4	1.4
Rheumatoid Arthritis	1.3	1.8	2.9	1.7	-0.7	-1.3
Lung FVC	1.3	6.7	13.3	-2.6	3.6	0.3
Sensitivity / hurt feelings	1.3	2.2	5.9	0.9	-2.4	-0.0
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	3.2	1.8	0.8	-0.8
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.1	-1.4	-0.6	-1.3
Alcohol usually taken with meals	1.3	2.0	5.9	0.1	-0.4	-2.4
Diabetes (self-reported)	1.3	2.0	5.9	2.4	-0.1	-0.0
Falls in the last year	1.3	1.8	2.3	-1.5	-0.9	1.5
Loud music exposure frequency	1.3	1.4	3.0	1.0	0.4	-1.7
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	4.9	1.2	2.2	0.5
Medication: Seretide 50 evohaler	1.3	1.5	4.2	0.6	0.2	2.0
Supplements: Vitamin C	1.3	1.5	3.0	-0.4	1.7	-1.2
Back pain experienced in last month	1.3	1.9	3.4	-1.2	-1.8	-0.9
Illnesses of father: None of the above (group 1)	1.3	1.6	4.7	-0.3	2.2	-0.3
Hearing aid user	1.3	1.5	4.3	0.3	0.1	-2.1
Basal cell carcinoma (self-reported)	1.3	1.5	2.7	-0.3	-1.3	-1.7
Prostate Cancer	1.2	1.7	3.2	-1.8	-1.1	-0.9
Stomach or abdominal pain in last month	1.2	1.5	2.5	-1.6	1.4	0.2
Medication: Ramipril	1.2	1.5	4.3	-2.1	-0.4	-0.4
Asthma	1.2	2.3	6.7	-0.6	-2.6	-0.1
Qualifications: O levels/GCSEs or equivalent	1.2	1.8	3.2	1.5	-1.8	0.4
Emphysema/chronic bronchitis	1.2	1.3	3.9	0.3	-0.2	2.0
Medication for pain relief, constipation, heartburn	1.2	2.0	5.6	-0.1	0.6	2.4
Illnesses of siblings: Diabetes	1.2	1.5	3.9	2.0	0.2	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.2	0.8	1.8	-0.6
Impedance of whole body	1.2	6.1	9.8	-3.1	-1.0	-2.7
Mean Putamen Volume	1.1	1.2	2.0	-0.5	1.2	-1.4
Respiratory disease	1.1	2.5	5.3	-0.7	-2.3	1.3
Type 2 Diabetes (T2D) (2018)	1.1	2.0	5.2	2.3	-0.3	-0.9
Supplements: Zinc	1.1	1.2	2.6	-0.2	1.0	1.6
Medication: Levothyroxine sodium	1.1	1.9	4.0	0.8	-1.1	-2.0
Age at first live birth	1.1	1.9	3.4	1.8	-1.6	0.2
Shortness of breath walking on level ground	1.1	1.3	3.9	-0.0	-2.0	-0.1
Eye problems/disorders: None of the above	1.1	1.3	2.8	-1.7	-0.9	-0.6
Had major operations	1.1	1.3	3.9	-0.1	-2.0	0.0
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.8	2.0	0.2	-0.0
Asthma (self-reported)	1.1	2.1	5.9	-0.7	-2.4	0.1
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.9	-1.7	0.4	-0.9
Medication: Atorvastatin	1.1	1.3	2.1	1.4	0.3	1.4
Cholesterol lowering medication	1.1	1.6	2.6	0.6	-1.6	-1.4
Supplements: Calcium	1.1	1.2	2.0	0.9	-1.0	1.4
Bipolar Disorder or Schizophrenia	1.0	2.4	3.7	-1.9	1.0	1.6
Relative age voice broke	1.0	1.5	3.0	-1.2	1.7	-0.2
Illnesses of siblings	1.0	1.3	2.2	1.3	0.3	1.5
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.5	-0.1	-0.2	1.9
Health satisfaction	1.0	1.3	2.0	-1.4	-1.3	0.4
Family relationship satisfaction	1.0	1.3	1.9	-1.4	-0.7	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.3	-0.5	1.1	1.5
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.1	0.8	1.0	-1.4
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.2	-0.5	1.5	-0.7
Diabetes (father)	0.9	1.1	2.2	1.5	-0.3	-0.9
Financial difficulties in last 2 years	0.9	1.1	1.7	-1.3	-1.1	0.8
Medication: Simvastatin	0.9	1.3	3.3	0.7	-1.8	-0.5
Pulse wave Arterial Stiffness index	0.9	1.0	2.2	0.5	-1.5	0.8
Pulse wave peak to peak time	0.9	1.0	2.4	-0.8	1.6	-0.1
Heart disease (mother)	0.9	1.1	2.0	-1.4	0.5	-1.0
Eye problems/disorders: Cataract	0.9	1.0	2.8	1.7	-0.1	0.4
Medication for cholesterol	0.9	1.4	2.4	0.6	1.2	1.5
Medication: Gliclazide	0.9	1.0	2.4	1.6	0.7	0.2
Commuting to job workplace: Public transport	0.9	1.1	2.0	0.1	-1.4	1.1
Ever smoked	0.9	1.6	3.6	-1.9	-0.5	1.0
Fractured/broken bones in last 5 years	0.9	1.1	1.5	-1.2	-1.2	0.6
Heart disease (siblings)	0.9	1.0	2.4	0.1	1.5	0.9
Bipolar Disorder (2018)	0.8	1.3	3.1	-1.7	0.9	0.3
Allergy or Eczema	0.8	2.0	4.5	-2.1	-0.1	-1.3
Serious illness, injury or assault to yourself	0.8	1.0	2.7	-0.3	0.3	-1.7
Chronic bronchitis/emphysema (father)	0.8	0.9	2.5	0.4	0.0	1.6
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.0	1.7	-1.4	0.7
Peak expiratory flow (PEF)	0.8	1.9	3.9	-1.0	0.8	2.0
Worry too long after embarrassment	0.8	1.4	2.3	-1.5	-0.9	1.0
Medication: Omeprazole	0.8	1.0	1.6	1.2	0.9	-0.8
Smoking status: Previous	0.8	1.2	1.8	1.2	0.7	1.3
Long-standing illness, disability or infirmity	0.8	1.2	3.5	0.3	-0.1	1.9
Mineral and other dietary supplements	0.8	1.1	2.3	-1.1	-0.0	1.5
Pain experienced in last month	0.8	1.4	3.0	0.5	1.7	1.0
Alcohol drinker status: Previous	0.8	0.9	1.9	0.9	-1.4	0.5
Pack years of smoking	0.8	1.1	2.9	-0.6	0.3	1.7
Schizophrenia (2018)	0.7	1.5	3.1	-1.0	0.6	1.8
LDL Cholesterol	0.7	1.2	2.6	0.6	-1.6	-0.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.8	-0.3	-1.4	-0.7
Pulse wave reflection index	0.7	0.9	1.6	-0.6	-0.9	-1.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.5	0.3	-1.3	-1.6
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.1	-1.4	0.4	0.5
Neck or shoulder pain in last month	0.7	1.0	2.2	-0.8	-1.5	0.1
Medication: Aspirin	0.7	0.9	1.2	-1.1	-1.0	-0.7
Ever taken oral contraceptive pill	0.7	0.8	2.0	0.5	-0.5	1.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.2	-0.1	-0.6	1.5
Ulcerative Colitis	0.6	0.8	2.3	0.3	-0.1	-1.5
Relative age of first facial hair	0.6	1.2	1.7	-1.2	1.3	0.8
Vitamin and mineral supplements	0.6	0.9	2.4	-1.6	-0.4	-0.2
Pack years adult smoking proportion	0.6	0.9	1.7	-0.9	0.2	1.3
Past tobacco smoking	0.6	1.2	3.3	0.3	0.1	-1.8
Allergy	0.6	1.3	3.4	1.9	0.5	0.6
Worrier / anxious feelings	0.6	1.1	3.0	-1.7	-0.6	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.7	-0.2	-0.7	-1.3
Migraine (self-reported)	0.6	0.7	1.2	-1.1	0.1	1.0
Medication: Allopurinol	0.6	0.8	1.5	-0.8	-1.2	0.4
High cholesterol (Self-reported)	0.6	1.1	3.2	-0.3	-1.8	-0.2
Ovarian Cancer	0.5	0.7	1.4	1.2	0.6	0.4
Tanning	0.5	6.5	17.9	-4.2	1.3	0.2
Maternal smoking around birth	0.5	0.7	1.8	-1.3	-0.6	-0.1
Pain all over the body in last month	0.5	0.5	1.0	1.0	-0.7	0.1
Father’s age at death	0.5	0.7	1.0	0.7	-0.8	-1.0
Noisy workplace	0.5	0.7	0.8	-0.8	0.9	0.7
Medication: Lansoprazole	0.5	0.6	1.2	0.2	-0.8	-1.1
Exposure to tobacco smoke at home	0.5	0.5	1.5	0.1	-0.1	-1.2
Birth weight of first child	0.5	0.8	1.1	0.7	1.1	0.9
Exposure to tobacco smoke outside home	0.5	0.6	1.2	0.1	-1.1	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.7	-0.3	0.1	1.3
Wheeze or whistling in the chest in last year	0.5	0.9	2.2	-1.5	-0.6	-0.2
Medication: Ibuprofen	0.5	0.7	1.2	0.6	-0.6	-1.1
Number of full sisters	0.5	0.6	1.1	-1.0	0.9	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.6	-0.8	0.7	-0.7
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.7	-0.1	-1.3	0.3
Taking other prescription medications	0.4	0.7	1.8	1.4	0.1	0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.2	1.1	0.2	-0.2
Qualifications: None of the above	0.4	0.9	2.4	-1.5	-0.6	-0.1
Heart attack	0.4	0.5	1.2	0.1	-0.6	1.1
Mouth/teeth dental problems: Dentures	0.4	0.6	1.1	-0.7	1.1	0.5
Medication: Cholesterol lowering	0.4	0.6	0.9	0.6	-0.8	0.9
Medication: Paracetamol	0.4	0.6	1.2	0.7	-0.4	-1.1
Headache pain in last month	0.4	0.7	1.5	-0.9	-0.1	-1.2
Gout (self-reported)	0.4	0.6	0.9	-0.9	-0.8	0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.3	-0.4	-1.1	0.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.3	0.4	-0.2	1.1
Wears glasses or contact lenses	0.4	0.4	0.9	0.6	0.1	0.9
Financial situation satisfaction	0.4	0.5	0.9	-0.6	-0.5	0.9
Medication: Paracetamol	0.4	0.7	1.7	1.3	-0.0	-0.6
Number of operations (self-reported)	0.4	0.6	1.4	1.2	0.2	-0.5
Irritability	0.4	0.6	0.9	-1.0	-0.9	0.3
Age started oral contraceptive pill	0.4	0.5	1.1	1.0	-0.7	-0.1
Age at First Birth	0.3	0.5	0.9	0.6	-1.0	-0.2
Crohns Disease (2012)	0.3	0.6	1.1	1.0	0.3	-0.7
Hypothyroidism (self reported)	0.3	0.7	1.1	0.7	-0.8	-1.0
Average weekly spirits intake	0.3	0.4	0.8	0.9	-0.1	0.5
Medication for hormone replacement therapy	0.3	0.4	0.6	0.1	0.7	0.8
Medication: Co-codamol	0.3	0.4	0.7	-0.2	-0.7	-0.8
Diabetes (mother)	0.3	0.3	0.5	0.7	-0.7	-0.1
Had menopause	0.3	0.3	0.9	0.4	-0.0	0.9
Number of full brothers	0.3	0.4	0.8	-0.7	-0.0	0.9
Qualifications: College or University degree	0.3	0.8	1.5	0.9	-1.2	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.8	-0.7	0.9	-0.4
Commuting to job workplace: Cycle	0.3	0.4	0.7	0.9	-0.4	-0.5
Alzheimer’s Disease (in father)	0.2	0.2	0.6	-0.8	-0.0	0.2
Crohns Disease (2017)	0.2	0.4	0.9	1.0	-0.2	-0.4
Coronary Artery Disease (CAD)	0.2	0.3	0.7	0.8	-0.4	0.1
HbA1C	0.2	0.3	0.6	-0.8	-0.3	0.2
Blood Red Count	0.2	2.1	5.8	2.4	0.7	-0.4
Lung FEV1/FVC ratio	0.2	1.0	1.7	0.8	1.3	-0.8
Chronotype (morning person)	0.2	0.4	0.9	0.9	0.6	-0.0
Hair Pigment	0.2	6.8	15.8	-1.4	4.0	1.6
Average weekly fortified wine intake	0.2	0.2	0.4	0.4	-0.6	0.3
Multivitamins +/- minerals	0.2	0.3	0.7	0.1	-0.8	0.2
Prospective memory result	0.2	0.2	0.3	0.4	0.5	0.5
Length of working week for main job	0.2	0.3	0.6	-0.3	0.8	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	0.2	-0.3	0.8
Age at last live birth	0.2	0.2	0.4	-0.6	-0.6	-0.1
Breast cancer (self-reported)	0.2	0.3	0.7	0.1	0.8	-0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.4	0.1	-0.7
Ulcerative Colitis (UC)	0.1	0.1	0.3	-0.1	0.4	-0.5
Hearing difficulty/problems: Yes	0.1	0.2	0.3	-0.2	-0.6	-0.2
Qualifications: CSEs or equivalent	0.1	0.2	0.5	-0.3	-0.7	0.1
Impedance of arm (right)	0.1	0.4	1.1	0.1	0.3	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.3	-0.3	-0.4
Impedance of arm (left)	0.1	0.4	0.9	0.4	-0.3	-1.0
Medication: Aspirin	0.1	0.2	0.3	-0.4	-0.5	-0.1
Mother’s age at death	0.1	0.2	0.4	0.2	-0.2	-0.7
Had other major operations	0.0	0.0	0.1	-0.0	0.1	-0.2
Average weekly red wine intake	0.0	0.0	0.0	0.2	-0.1	0.0

Hub : Genes

CELF1

Models

Trait associations