Hub : Genes

CELF1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.0810 0.0383 0.0012 0.020 NA 0.060 NA 0.035 1.3e-02 NA 4.3e-05 NA 0.00170
2 GTEx Prostate 0.1750 0.0820 0.0060 0.159 NA 0.103 NA 0.121 8.6e-05 NA 1.5e-03 NA 0.00062
3 ROSMAP Brain Pre-frontal Cortex 0.0275 0.0173 0.0150 0.011 0.003 0.004 0.008 0.005 1.1e-02 0.11 9.1e-02 0.029 0.05800

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.8 1.3 3.1 -1.7 0.9 0.3
Bipolar Disorder or Schizophrenia 1.0 2.4 3.7 -1.9 1.0 1.6
Depressed Affect (Nagel 2018) 10.9 22.9 39.3 -5.3 -6.3 -0.9
Depression (Nagel 2018) 3.6 5.5 12.5 -1.8 -3.5 0.8
Intelligence (Savage-Jansen 2018) 1.3 3.9 8.9 -1.4 -0.9 3.0
Neuroticism (Nagel 2018) 6.9 16.3 25.9 -4.8 -5.1 -0.6
Schizophrenia (2018) 0.7 1.5 3.1 -1.0 0.6 1.8
Schizophrenia vs Biploar Disorder 1.7 2.2 3.7 -1.6 1.9 0.7
Worry (Nagel 2018) 3.8 7.9 18.2 -4.3 -2.3 -0.4
Alzheimer’s Disease (in mother) 1.9 2.2 3.8 -2.0 1.1 -1.2
Alzheimer’s Disease (in father) 0.2 0.2 0.6 -0.8 -0.0 0.2
Alzheimer’s Disease (including proxy) 3.6 5.2 14.1 -3.8 0.9 -0.8
Crohns Disease (2017) 0.2 0.4 0.9 1.0 -0.2 -0.4
Irritable Bowel Disease (IBD) 0.1 0.2 0.5 0.4 0.1 -0.7
Ulcerative Colitis (UC) 0.1 0.1 0.3 -0.1 0.4 -0.5
Major Depression (MDD) 1.5 1.8 3.2 -0.7 -1.3 1.8
Reaction Time 5.4 10.4 23.6 0.9 4.9 2.6
Verbal and Numeric Reasoning (VNR) 2.0 4.9 11.6 -0.9 -1.5 3.4
Breast Cancer 2.3 5.5 9.3 -3.0 -1.0 -2.5
Ovarian Cancer 0.5 0.7 1.4 1.2 0.6 0.4
Prostate Cancer 1.2 1.7 3.2 -1.8 -1.1 -0.9
Age at First Birth 0.3 0.5 0.9 0.6 -1.0 -0.2
Bipolar Disorder (2011) 1.3 1.3 2.0 -0.2 1.4 1.4
Body Mass Index (BMI) (2010) 4.4 6.0 17.1 4.1 -0.4 -0.9
Coronary Artery Disease (CAD) 0.2 0.3 0.7 0.8 -0.4 0.1
Crohns Disease (2012) 0.3 0.6 1.1 1.0 0.3 -0.7
Mean Putamen Volume 1.1 1.2 2.0 -0.5 1.2 -1.4
Fasting Glucose 7.6 9.1 10.8 3.2 2.5 3.3
HbA1C 0.2 0.3 0.6 -0.8 -0.3 0.2
HDL Cholesterol 11.3 18.9 35.3 -1.3 4.4 5.9
LDL Cholesterol 0.7 1.2 2.6 0.6 -1.6 -0.7
Lupus 1.6 2.4 6.3 0.9 -0.4 2.5
Neuroticism (2016) 4.9 7.1 10.7 -3.3 -3.3 -0.3
Primary Biliary Cirrhosis 2.5 3.6 7.3 -1.2 1.4 2.7
Rheumatoid Arthritis 1.3 1.8 2.9 1.7 -0.7 -1.3
Schizophrenia (2014) 1.7 3.7 4.2 -2.0 1.7 2.0
Triglycerides 2.0 3.2 5.0 0.8 -2.2 -2.0
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.2 -0.5 1.5 -0.7
Ulcerative Colitis 0.6 0.8 2.3 0.3 -0.1 -1.5
Blood Eosinophil Count 3.6 27.5 55.8 -5.0 1.3 -7.5
Blood Platelet Count 3.1 35.6 70.2 -6.0 0.0 8.4
Blood Red Count 0.2 2.1 5.8 2.4 0.7 -0.4
Blood White Count 4.5 33.3 99.0 -0.9 0.2 -9.9
Heel T-Score 9.5 75.3 219.0 -1.4 14.8 2.2
BMI 3.1 18.1 46.6 6.8 -0.2 -2.8
Height 4.2 81.8 234.1 -1.2 3.1 15.3
Waist Hip Ratio (WHR) 2.1 9.5 21.2 2.7 -0.0 4.6
Systolic Blood Pressure 11.3 56.8 112.4 -10.6 -7.4 -1.8
Smoking Status 1.7 4.0 5.3 -2.3 1.3 2.3
Allergy or Eczema 0.8 2.0 4.5 -2.1 -0.1 -1.3
Cardiovascular Disease 4.3 14.3 19.4 -4.4 -3.5 -3.3
Hypothyroidism (self reported) 0.3 0.7 1.1 0.7 -0.8 -1.0
Respiratory disease 1.1 2.5 5.3 -0.7 -2.3 1.3
Type 2 Diabetes (T2D) (2018) 1.1 2.0 5.2 2.3 -0.3 -0.9
Lung FEV1/FVC ratio 0.2 1.0 1.7 0.8 1.3 -0.8
Lung FVC 1.3 6.7 13.3 -2.6 3.6 0.3
Neuroticism 7.1 17.1 34.2 -4.1 -5.9 0.7
Chronotype (morning person) 0.2 0.4 0.9 0.9 0.6 -0.0
Hair Pigment 0.2 6.8 15.8 -1.4 4.0 1.6
Tanning 0.5 6.5 17.9 -4.2 1.3 0.2
Hand grip strength (left) 4.1 10.8 26.4 -5.1 1.3 2.1
Number of treatments/medications taken 1.9 3.4 7.4 1.6 -2.7 -0.3
Average weekly spirits intake 0.3 0.4 0.8 0.9 -0.1 0.5
Sensitivity / hurt feelings 1.3 2.2 5.9 0.9 -2.4 -0.0
Frequency of depressed mood in last 2 weeks 4.6 6.5 11.0 -2.9 -3.3 -0.2
Hearing difficulty/problems: Yes 0.1 0.2 0.3 -0.2 -0.6 -0.2
Relative age of first facial hair 0.6 1.2 1.7 -1.2 1.3 0.8
Other serious medical condition/disability diagnosed by doctor 2.0 2.6 6.4 1.2 -0.1 2.5
Ever used hormone-replacement therapy (HRT) 3.2 4.1 5.9 2.4 -2.0 -1.5
Ever had hysterectomy (womb removed) 1.5 1.6 3.0 1.1 -0.9 -1.7
Systolic blood pressure, automated reading 5.4 15.6 26.3 -4.4 -5.1 -0.9
Eye problems/disorders: Diabetes related eye disease 1.3 1.5 3.2 1.8 0.8 -0.8
Angina 2.3 3.0 7.1 -0.2 -1.4 -2.7
Medication for hormone replacement therapy 0.3 0.4 0.6 0.1 0.7 0.8
Vitamin and mineral supplements 0.6 0.9 2.4 -1.6 -0.4 -0.2
Supplements: Zinc 1.1 1.2 2.6 -0.2 1.0 1.6
Medication: Co-codamol 0.3 0.4 0.7 -0.2 -0.7 -0.8
Medication: Metformin 2.5 3.5 9.4 3.1 1.0 0.4
Diabetes (father) 0.9 1.1 2.2 1.5 -0.3 -0.9
Diabetes (mother) 0.3 0.3 0.5 0.7 -0.7 -0.1
Severe depression (siblings) 3.4 3.8 7.0 -0.6 2.0 2.6
Pack years adult smoking proportion 0.6 0.9 1.7 -0.9 0.2 1.3
Impedance of leg (right) 3.3 16.1 37.0 -6.1 -0.9 -3.2
Leg fat-free mass (left) 3.6 18.9 32.2 4.6 1.7 5.7
Trunk fat percentage 3.8 15.3 37.7 6.1 -1.0 -2.7
Hand grip strength (right) 2.9 8.0 21.5 -4.6 0.2 1.6
Townsend deprivation index at recruitment 1.9 2.7 6.2 -0.9 -1.1 2.5
Current tobacco smoking 2.9 4.7 11.0 -3.3 -0.4 1.7
Average weekly fortified wine intake 0.2 0.2 0.4 0.4 -0.6 0.3
Maternal smoking around birth 0.5 0.7 1.8 -1.3 -0.6 -0.1
Fed-up feelings 9.2 16.7 38.4 -3.2 -6.2 -1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 2.7 3.6 7.8 -1.2 -2.8 1.3
Relative age voice broke 1.0 1.5 3.0 -1.2 1.7 -0.2
Taking other prescription medications 0.4 0.7 1.8 1.4 0.1 0.3
Age when periods started (menarche) 1.4 3.4 10.0 -3.2 0.4 0.2
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.8 -0.3 -1.4 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 7.0 15.9 43.4 0.4 6.6 2.0
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 2.1 -1.4 -0.6 -1.3
Qualifications: CSEs or equivalent 0.1 0.2 0.5 -0.3 -0.7 0.1
Serious illness, injury or assault to yourself 0.8 1.0 2.7 -0.3 0.3 -1.7
High blood pressure 9.7 27.2 28.2 -5.3 -5.1 -5.2
Hayfever, allergic rhinitis or eczema 1.5 3.2 7.1 -2.7 -0.2 -1.5
Multivitamins +/- minerals 0.2 0.3 0.7 0.1 -0.8 0.2
Stomach or abdominal pain in last month 1.2 1.5 2.5 -1.6 1.4 0.2
Supplements: Glucosamine 1.5 2.0 3.4 1.2 1.8 1.0
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.2 1.1 0.2 -0.2
Medication: Atenolol 2.4 3.0 5.5 -2.3 1.2 -1.4
Medication: Levothyroxine sodium 1.1 1.9 4.0 0.8 -1.1 -2.0
Sitting height 3.8 26.7 53.1 -4.6 2.4 7.3
Chronic bronchitis/emphysema (father) 0.8 0.9 2.5 0.4 0.0 1.6
High blood pressure (mother) 1.9 2.6 6.5 -0.9 -2.6 -0.7
Body mass index (BMI) 3.3 14.0 36.0 6.0 -0.4 -2.4
Impedance of leg (left) 3.4 16.4 37.1 -6.1 -1.0 -3.4
Leg predicted mass (left) 3.6 19.0 31.9 4.7 1.7 5.6
Trunk fat mass 2.7 11.6 34.5 5.9 -0.2 -0.5
Waist circumference 3.9 14.4 42.3 6.5 -0.9 0.3
Number of incorrect matches in round 2.8 4.6 11.8 1.4 3.4 -0.3
Past tobacco smoking 0.6 1.2 3.3 0.3 0.1 -1.8
Alcohol usually taken with meals 1.3 2.0 5.9 0.1 -0.4 -2.4
Nervous feelings 2.2 4.1 8.5 -2.9 -1.7 -0.9
Frequency of tenseness / restlessness in last 2 weeks 2.3 3.6 7.6 -2.8 -1.6 0.6
Hearing difficulty/problems with background noise 5.1 8.2 19.2 -1.7 -4.4 -1.6
Hair/balding pattern: Pattern 2 1.9 2.4 5.2 -2.3 1.1 0.9
Had menopause 0.3 0.3 0.9 0.4 -0.0 0.9
Had other major operations 0.0 0.0 0.1 -0.0 0.1 -0.2
Forced vital capacity (FVC) 3.3 12.6 21.6 -2.3 3.3 4.7
Heel bone mineral density (BMD) T-score, automated (right) 8.5 19.5 52.3 0.8 7.2 2.4
Ever unenthusiastic/disinterested for a whole week 2.8 3.4 7.1 -0.4 1.7 2.7
Qualifications: None of the above 0.4 0.9 2.4 -1.5 -0.6 -0.1
Financial difficulties in last 2 years 0.9 1.1 1.7 -1.3 -1.1 0.8
Mouth/teeth dental problems 2.4 3.6 5.0 2.2 -1.4 2.0
Heart attack 0.4 0.5 1.2 0.1 -0.6 1.1
Allergy 0.6 1.3 3.4 1.9 0.5 0.6
Pain all over the body in last month 0.5 0.5 1.0 1.0 -0.7 0.1
Diabetes (self-reported) 1.3 2.0 5.9 2.4 -0.1 -0.0
Hayfever/allergic rhinitis (self-reported) 4.0 5.3 9.9 -1.2 -3.1 -2.1
Medication: Ramipril 1.2 1.5 4.3 -2.1 -0.4 -0.4
Medication: Simvastatin 0.9 1.3 3.3 0.7 -1.8 -0.5
Fluid intelligence score 1.5 3.2 5.9 -1.8 -0.6 2.4
Illnesses of siblings 1.0 1.3 2.2 1.3 0.3 1.5
Neuroticism score 6.4 13.3 20.7 -4.4 -4.5 0.4
Weight 2.3 11.3 24.3 4.9 0.7 3.0
Impedance of arm (right) 0.1 0.4 1.1 0.1 0.3 -1.0
Arm fat percentage (right) 4.8 18.9 43.8 6.6 -0.4 -3.5
Trunk fat-free mass 4.4 25.1 65.0 1.3 3.0 8.1
Hip circumference 2.6 11.2 30.4 5.5 -1.7 -0.7
Time employed in main current job 2.3 2.7 7.3 -0.6 2.7 0.6
Alcohol intake versus 10 years previously 1.4 2.1 3.6 1.9 1.5 -0.7
Father’s age at death 0.5 0.7 1.0 0.7 -0.8 -1.0
Worrier / anxious feelings 0.6 1.1 3.0 -1.7 -0.6 0.0
Frequency of tiredness / lethargy in last 2 weeks 3.8 6.2 11.7 -0.3 -3.4 2.6
Falls in the last year 1.3 1.8 2.3 -1.5 -0.9 1.5
Hair/balding pattern: Pattern 3 1.4 2.0 4.1 2.0 -1.0 -1.0
Number of live births 1.4 2.0 4.1 -2.0 1.3 -0.5
Forced expiratory volume in 1-second (FEV1) 2.1 7.0 9.7 -1.7 2.9 3.1
Pulse rate 2.0 3.4 5.6 2.4 0.1 2.1
Happiness 2.0 2.4 6.4 0.2 -2.5 0.8
Noisy workplace 0.5 0.7 0.8 -0.8 0.9 0.7
Qualifications: A levels/AS levels or equivalent 0.8 1.8 3.0 1.7 -1.4 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.2 -0.3 -0.3 -0.4
Mouth/teeth dental problems: Dentures 0.4 0.6 1.1 -0.7 1.1 0.5
Asthma 1.2 2.3 6.7 -0.6 -2.6 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 1.7 -0.2 -0.7 -1.3
Medication: Cholesterol lowering 0.4 0.6 0.9 0.6 -0.8 0.9
Depression (self-reported) 2.8 3.3 8.8 0.2 -1.0 3.0
Medication: Lansoprazole 0.5 0.6 1.2 0.2 -0.8 -1.1
Prospective memory result 0.2 0.2 0.3 0.4 0.5 0.5
Lung cancer (father) 2.2 2.5 3.0 -1.7 1.6 1.4
Illnesses of mother 1.7 2.1 3.5 1.9 1.5 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 3.1 9.8 13.8 -1.6 3.6 3.7
Pulse wave Arterial Stiffness index 0.9 1.0 2.2 0.5 -1.5 0.8
Impedance of arm (left) 0.1 0.4 0.9 0.4 -0.3 -1.0
Arm fat mass (right) 3.1 12.7 37.1 6.1 0.0 -1.1
Trunk predicted mass 4.3 24.8 64.2 1.3 2.9 8.0
Standing height 4.8 48.1 132.2 -1.9 2.9 11.5
Length of working week for main job 0.2 0.3 0.6 -0.3 0.8 0.2
Exposure to tobacco smoke at home 0.5 0.5 1.5 0.1 -0.1 -1.2
Breastfed as a baby 2.8 3.4 9.6 -0.1 0.8 3.1
Tense / ‘highly strung’ 3.2 5.2 11.6 -3.4 -0.9 -1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.7 7.0 -0.5 -2.0 2.6
Hair/balding pattern: Pattern 4 2.7 6.6 15.2 1.6 -3.9 -1.4
Birth weight of first child 0.5 0.8 1.1 0.7 1.1 0.9
Peak expiratory flow (PEF) 0.8 1.9 3.9 -1.0 0.8 2.0
Pulse wave reflection index 0.7 0.9 1.6 -0.6 -0.9 -1.3
Ever highly irritable/argumentative for 2 days 1.0 1.2 3.5 -0.1 -0.2 1.9
Loud music exposure frequency 1.3 1.4 3.0 1.0 0.4 -1.7
Qualifications: O levels/GCSEs or equivalent 1.2 1.8 3.2 1.5 -1.8 0.4
Mouth/teeth dental problems: Bleeding gums 4.0 5.2 10.0 -2.1 1.1 -3.2
Blood clot in the leg (DVT) 2.0 2.6 4.0 -1.0 1.7 2.0
Medication: Paracetamol 0.4 0.6 1.2 0.7 -0.4 -1.1
Headache pain in last month 0.4 0.7 1.5 -0.9 -0.1 -1.2
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 4.9 1.2 2.2 0.5
Glaucoma (self-reported) 2.1 2.5 5.5 0.4 1.3 2.3
Gout (self-reported) 0.4 0.6 0.9 -0.9 -0.8 0.6
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 2.5 0.3 -1.3 -1.6
Medication: Amlodipine 2.5 3.4 5.2 -1.9 -2.3 -1.2
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.3 -0.4 -1.1 0.2
Birth weight 2.1 4.5 10.9 -1.5 0.6 3.3
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.1 -1.4 0.4 0.5
High blood pressure (siblings) 4.7 6.7 11.4 -3.4 -0.7 -2.9
Forced vital capacity (FVC), Best measure 4.8 17.5 27.4 -2.6 4.3 5.2
Body fat percentage 3.8 15.1 30.5 5.5 -1.2 -3.7
Leg fat percentage (right) 3.5 12.8 24.0 3.6 -1.3 -4.9
Arm fat-free mass (right) 2.5 12.8 34.7 1.4 1.3 5.9
Exposure to tobacco smoke outside home 0.5 0.6 1.2 0.1 -1.1 -0.8
Comparative body size at age 10 2.6 7.1 21.2 4.6 0.0 -0.2
Number of full brothers 0.3 0.4 0.8 -0.7 -0.0 0.9
Worry too long after embarrassment 0.8 1.4 2.3 -1.5 -0.9 1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.7 -0.3 0.1 1.3
Wheeze or whistling in the chest in last year 0.5 0.9 2.2 -1.5 -0.6 -0.2
Number of children fathered 1.9 2.2 5.7 0.3 2.4 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.6 0.2 -0.3 0.8
Age at first live birth 1.1 1.9 3.4 1.8 -1.6 0.2
Pulse wave peak to peak time 0.9 1.0 2.4 -0.8 1.6 -0.1
Health satisfaction 1.0 1.3 2.0 -1.4 -1.3 0.4
Shortness of breath walking on level ground 1.1 1.3 3.9 -0.0 -2.0 -0.1
Qualifications: College or University degree 0.3 0.8 1.5 0.9 -1.2 -0.4
Eye problems/disorders: None of the above 1.1 1.3 2.8 -1.7 -0.9 -0.6
Mouth/teeth dental problems: Loose teeth 1.4 1.7 4.1 -2.0 -0.3 -0.9
Emphysema/chronic bronchitis 1.2 1.3 3.9 0.3 -0.2 2.0
Medication for pain relief, constipation, heartburn 1.2 2.0 5.6 -0.1 0.6 2.4
Neck or shoulder pain in last month 0.7 1.0 2.2 -0.8 -1.5 0.1
Medication: Blood pressure 4.3 7.6 10.1 -3.2 -3.0 -2.0
Angina (self-reported) 2.2 2.9 7.6 -0.3 -1.1 -2.8
Migraine (self-reported) 0.6 0.7 1.2 -1.1 0.1 1.0
Medication: Ibuprofen 0.5 0.7 1.2 0.6 -0.6 -1.1
Medication: Allopurinol 0.6 0.8 1.5 -0.8 -1.2 0.4
Medication: Omeprazole 0.8 1.0 1.6 1.2 0.9 -0.8
Medication: Seretide 50 evohaler 1.3 1.5 4.2 0.6 0.2 2.0
Mean time to correctly identify matches 7.1 13.6 29.6 0.7 5.4 3.3
Heart disease (mother) 0.9 1.1 2.0 -1.4 0.5 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.3 2.7 3.9 -1.5 -1.5 -2.0
Whole body fat mass 2.5 10.5 30.1 5.5 -0.3 -1.1
Leg fat mass (right) 2.0 7.9 20.0 4.5 -0.5 -1.9
Arm predicted mass (right) 2.6 13.2 35.2 1.6 1.5 5.9
Pulse rate, automated reading 3.0 9.9 18.2 4.3 0.3 3.4
Alcohol intake frequency. 2.3 5.3 10.3 3.2 1.1 -2.1
Comparative height size at age 10 3.9 21.6 56.1 -0.7 2.9 7.5
Number of full sisters 0.5 0.6 1.1 -1.0 0.9 -0.2
Suffer from ‘nerves’ 5.6 8.9 13.1 -3.6 -3.3 1.6
Overall health rating 1.8 3.9 9.8 -0.9 -3.1 1.0
Chest pain or discomfort 2.2 3.1 7.5 -2.7 -0.8 1.1
Had major operations 1.1 1.3 3.9 -0.1 -2.0 0.0
Age at last live birth 0.2 0.2 0.4 -0.6 -0.6 -0.1
Family relationship satisfaction 1.0 1.3 1.9 -1.4 -0.7 1.2
Leg pain on walking 2.0 2.5 6.6 -2.6 -0.8 -0.4
Qualifications: NVQ or HND or HNC or equivalent 2.6 3.1 8.8 0.5 3.0 -0.6
Commuting to job workplace: Car/motor vehicle 2.9 3.4 8.8 -0.4 3.0 -1.1
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 3.8 2.0 0.2 -0.0
Medication: Aspirin 0.7 0.9 1.2 -1.1 -1.0 -0.7
Supplements: Vitamin C 1.3 1.5 3.0 -0.4 1.7 -1.2
Knee pain experienced in last month 1.7 2.6 5.7 0.2 1.4 2.4
Hypertension (Self-reported) 9.1 25.2 27.5 -5.2 -4.8 -5.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 2.3 -0.5 1.1 1.5
Illnesses of father: Heart disease 1.6 2.3 3.3 0.9 -1.8 1.6
Illnesses of siblings: Diabetes 1.2 1.5 3.9 2.0 0.2 -0.6
Smoking status: Previous 0.8 1.2 1.8 1.2 0.7 1.3
Forced expiratory volume in 1-second (FEV1), predicted 3.4 7.0 14.8 -0.7 2.4 3.8
Whole body fat-free mass 3.7 21.2 51.0 2.6 2.4 7.1
Leg fat-free mass (right) 3.8 20.2 36.0 4.7 1.7 6.0
Arm fat percentage (left) 5.3 21.0 48.6 7.0 -0.9 -3.7
Average weekly red wine intake 0.0 0.0 0.0 0.2 -0.1 0.0
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.3 0.4 -0.2 1.1
Mood swings 6.8 12.4 22.5 -4.7 -3.5 -1.5
Loneliness, isolation 5.8 8.0 10.2 -2.7 -3.2 2.5
Long-standing illness, disability or infirmity 0.8 1.2 3.5 0.3 -0.1 1.9
Ever had bowel cancer screening 1.5 1.8 3.2 1.8 1.2 -0.7
Diabetes diagnosed by doctor 1.6 2.6 7.5 2.7 0.4 0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 0.6 -0.8 0.7 -0.7
Friendships satisfaction 1.4 1.7 2.4 -1.6 -1.4 1.0
Qualifications: nursing, teaching 1.5 2.3 3.8 1.7 -1.9 0.4
Commuting to job workplace: Walk 2.0 2.1 5.6 -0.3 -2.4 0.8
Eye problems/disorders: Cataract 0.9 1.0 2.8 1.7 -0.1 0.4
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.8 -0.7 0.9 -0.4
Medication for cholesterol 0.9 1.4 2.4 0.6 1.2 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 3.2 0.8 1.8 -0.6
Back pain experienced in last month 1.3 1.9 3.4 -1.2 -1.8 -0.9
Mineral and other dietary supplements 0.8 1.1 2.3 -1.1 -0.0 1.5
Breast cancer (self-reported) 0.2 0.3 0.7 0.1 0.8 -0.2
Asthma (self-reported) 1.1 2.1 5.9 -0.7 -2.4 0.1
Osteoporosis (self-reported) 1.5 1.9 5.5 0.2 -2.3 -0.2
Osteoarthritis (self-reported) 1.7 2.2 4.5 1.1 -1.0 2.1
Medication: Aspirin 0.1 0.2 0.3 -0.4 -0.5 -0.1
Medication: Gliclazide 0.9 1.0 2.4 1.6 0.7 0.2
Illnesses of father: None of the above (group 1) 1.3 1.6 4.7 -0.3 2.2 -0.3
Smoking status: Current 3.0 4.8 11.6 -3.4 -0.4 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.2 8.1 -0.8 2.8 -0.9
Whole body water mass 3.8 21.9 52.7 2.7 2.4 7.3
Leg predicted mass (right) 3.7 19.9 35.3 4.6 1.8 5.9
Arm fat mass (left) 3.3 13.4 39.3 6.3 0.0 -0.9
Number of self-reported non-cancer illnesses 3.1 5.4 14.0 -1.5 -3.7 0.1
Average weekly champagne plus white wine intake 1.8 2.4 5.5 -2.4 1.3 -0.4
Miserableness 9.8 17.0 28.2 -4.6 -5.3 -1.3
Guilty feelings 5.1 7.7 16.6 -4.1 -2.4 1.0
Wears glasses or contact lenses 0.4 0.4 0.9 0.6 0.1 0.9
Ever taken oral contraceptive pill 0.7 0.8 2.0 0.5 -0.5 1.4
Hearing aid user 1.3 1.5 4.3 0.3 0.1 -2.1
Mother’s age at death 0.1 0.2 0.4 0.2 -0.2 -0.7
Financial situation satisfaction 0.4 0.5 0.9 -0.6 -0.5 0.9
Tinnitus: Yes, now most or all of the time 1.1 1.3 2.9 -1.7 0.4 -0.9
Commuting to job workplace: Public transport 0.9 1.1 2.0 0.1 -1.4 1.1
Eye problems/disorders: Glaucoma 4.0 4.7 11.5 1.0 1.3 3.4
Medication: Blood pressure 4.2 8.0 13.4 -2.6 -2.0 -3.7
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.7 -0.1 -1.3 0.3
Supplements: Fish oil (including cod liver oil) 1.5 2.0 4.4 2.1 1.0 -0.7
High cholesterol (Self-reported) 0.6 1.1 3.2 -0.3 -1.8 -0.2
Medication: Bendroflumethiazide 5.7 8.7 13.8 -3.7 -2.4 -2.5
Medication: Paracetamol 0.4 0.7 1.7 1.3 -0.0 -0.6
Medication: Lisinopril 3.5 4.5 6.2 -2.0 -2.5 -1.8
Medication: Atorvastatin 1.1 1.3 2.1 1.4 0.3 1.4
Illnesses of father: High blood pressure 7.5 9.2 21.9 -4.7 -0.3 -2.4
Alcohol drinker status: Never 1.8 2.1 3.9 1.6 -0.1 -2.0
Ever smoked 0.9 1.6 3.6 -1.9 -0.5 1.0
Basal metabolic rate 3.2 17.8 38.1 3.4 2.0 6.2
Leg fat percentage (left) 3.7 13.2 24.3 3.8 -1.2 -4.9
Arm fat-free mass (left) 2.5 12.6 32.5 1.7 1.6 5.7
Number of operations (self-reported) 0.4 0.6 1.4 1.2 0.2 -0.5
Average weekly beer plus cider intake 3.3 4.8 6.6 -2.6 1.6 2.2
Irritability 0.4 0.6 0.9 -1.0 -0.9 0.3
Risk taking 1.4 2.1 4.0 0.3 1.4 2.0
Ever had prostate specific antigen (PSA) test 1.4 1.6 3.7 1.0 -1.9 0.4
Fractured/broken bones in last 5 years 0.9 1.1 1.5 -1.2 -1.2 0.6
Age started oral contraceptive pill 0.4 0.5 1.1 1.0 -0.7 -0.1
Diastolic blood pressure, automated reading 5.0 15.5 27.4 -5.2 -3.4 -2.8
Ever depressed for a whole week 2.1 2.6 6.9 0.6 0.7 2.6
Unable to work because of sickness or disability 1.9 2.4 7.1 -0.0 -0.4 2.7
Commuting to job workplace: Cycle 0.3 0.4 0.7 0.9 -0.4 -0.5
Myopia 2.2 3.2 7.1 -1.2 0.9 2.7
Vascular/heart problems diagnosed by doctor 8.0 21.7 24.0 4.6 4.9 4.5
Cholesterol lowering medication 1.1 1.6 2.6 0.6 -1.6 -1.4
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 2.1 0.8 1.0 -1.4
Pain experienced in last month 0.8 1.4 3.0 0.5 1.7 1.0
Supplements: Calcium 1.1 1.2 2.0 0.9 -1.0 1.4
Basal cell carcinoma (self-reported) 1.3 1.5 2.7 -0.3 -1.3 -1.7
Heart attack/myocardial infarction (self-reported) 0.7 0.9 2.2 -0.1 -0.6 1.5
Deep venous thrombosis (DVT) (self-reported) 2.3 2.9 4.0 -1.0 2.0 2.0
Heart disease (siblings) 0.9 1.0 2.4 0.1 1.5 0.9
Alcohol drinker status: Previous 0.8 0.9 1.9 0.9 -1.4 0.5
Pack years of smoking 0.8 1.1 2.9 -0.6 0.3 1.7
Impedance of whole body 1.2 6.1 9.8 -3.1 -1.0 -2.7
Leg fat mass (left) 2.0 7.9 20.7 4.5 -0.1 -1.7
Arm predicted mass (left) 2.4 12.3 31.8 1.7 1.5 5.6