Best TWAS P=3.52e-14 · Best GWAS P=3.14e-15 conditioned to 9.44e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RPS6KB1 | 0.04 | 0.00 | bslmm | 275 | 0.01 | 1.7e-02 | 3.2 | 7.6 | 3.5e-14 | -0.67 | 0.03 | 0.82 | TRUE |
2 | GTEx | Adipose Subcutaneous | SUPT4H1 | 0.07 | 0.08 | lasso | 2 | 0.07 | 2.5e-06 | 5.3 | -5.3 | 1.1e-07 | 0.01 | 0.03 | 0.96 | FALSE |
3 | GTEx | Adipose Visceral Omentum | SUPT4H1 | 0.10 | 0.04 | lasso | 6 | 0.04 | 3.7e-03 | 4.4 | -5.2 | 1.9e-07 | 0.07 | 0.03 | 0.83 | FALSE |
4 | GTEx | Artery Tibial | SUPT4H1 | 0.13 | 0.14 | lasso | 4 | 0.12 | 4.9e-10 | 5.2 | -5.4 | 6.3e-08 | 0.02 | 0.02 | 0.98 | FALSE |
5 | GTEx | Brain Cerebellum | SUPT4H1 | 0.26 | 0.10 | enet | 30 | 0.16 | 1.4e-05 | 5.6 | -5.8 | 6.3e-09 | 0.06 | 0.06 | 0.83 | FALSE |
6 | GTEx | Colon Transverse | SUPT4H1 | 0.24 | 0.17 | lasso | 4 | 0.14 | 5.8e-07 | 5.3 | -5.3 | 1.1e-07 | 0.01 | 0.03 | 0.97 | FALSE |
7 | GTEx | Esophagus Mucosa | SUPT4H1 | 0.07 | 0.04 | lasso | 3 | 0.04 | 6.1e-04 | 5.6 | -5.5 | 3.7e-08 | 0.01 | 0.02 | 0.97 | FALSE |
8 | GTEx | Esophagus Muscularis | SUPT4H1 | 0.14 | 0.15 | lasso | 2 | 0.13 | 2.3e-08 | 5.3 | -5.3 | 1.1e-07 | 0.01 | 0.03 | 0.97 | FALSE |
9 | GTEx | Heart Atrial Appendage | RAD51C | 0.14 | 0.06 | lasso | 6 | 0.07 | 4.5e-04 | 5.2 | -5.3 | 1.1e-07 | -0.01 | 0.06 | 0.69 | FALSE |
10 | GTEx | Muscle Skeletal | SUPT4H1 | 0.14 | 0.12 | enet | 24 | 0.12 | 1.2e-11 | 5.2 | -5.9 | 3.5e-09 | 0.01 | 0.02 | 0.98 | FALSE |
11 | GTEx | Nerve Tibial | SUPT4H1 | 0.21 | 0.10 | lasso | 4 | 0.07 | 6.8e-06 | 5.2 | -5.2 | 2.6e-07 | 0.00 | 0.03 | 0.96 | FALSE |
12 | GTEx | Testis | SUPT4H1 | 0.17 | 0.10 | lasso | 7 | 0.07 | 6.4e-04 | 5.2 | -6.0 | 2.2e-09 | -0.02 | 0.03 | 0.93 | TRUE |
13 | GTEx | Thyroid | SUPT4H1 | 0.07 | 0.05 | lasso | 2 | 0.08 | 1.5e-06 | 5.1 | -6.0 | 2.4e-09 | 0.01 | 0.04 | 0.93 | FALSE |
14 | GTEx | Vagina | HEATR6 | 0.28 | 0.02 | lasso | 10 | 0.01 | 1.8e-01 | -7.6 | -6.3 | 2.2e-10 | 0.91 | 0.02 | 0.71 | FALSE |
15 | NTR | Blood | MIR21 | 0.01 | 0.02 | lasso | 2 | 0.02 | 9.0e-06 | -4.2 | -5.5 | 3.3e-08 | 0.81 | 0.14 | 0.86 | FALSE |
16 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CLTC | 0.07 | 0.03 | lasso | 3 | 0.02 | 1.5e-02 | -7.0 | -7.1 | 1.6e-12 | 0.88 | 0.00 | 0.94 | FALSE |
17 | The Cancer Genome Atlas | Thyroid Carcinoma | BZRAP1 | 0.05 | 0.04 | blup | 59 | 0.03 | 2.7e-04 | -3.2 | 5.9 | 2.8e-09 | 0.00 | 0.02 | 0.67 | FALSE |
18 | The Cancer Genome Atlas | Thyroid Carcinoma | SUPT4H1 | 0.05 | 0.04 | lasso | 3 | 0.03 | 9.5e-04 | 5.2 | -5.3 | 1.3e-07 | -0.02 | 0.01 | 0.98 | FALSE |