[Hub]/) : Traits : Blood Eosinophil Count :

chr17:65,123,352-66,885,526

Best TWAS P=1.06e-38 · Best GWAS P=6.21e-39 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous LINC00674 0.12 0.13 enet 6 0.14 9.9e-12 11.7 12.3 6.8e-35 0.79 0.97 0.03 TRUE
2 GTEx Adipose Subcutaneous LRRC37A16P 0.10 0.10 enet 10 0.14 2.9e-11 11.9 8.4 3.7e-17 0.60 0.96 0.03 TRUE
3 GTEx Adipose Subcutaneous SH3GL1P3 0.08 0.06 lasso 5 0.04 2.5e-04 11.7 11.6 3.2e-31 0.80 0.08 0.87 FALSE
4 GTEx Adipose Subcutaneous RP11-147L13.8 0.28 0.09 enet 27 0.23 9.7e-19 7.1 7.1 9.2e-13 0.46 1.00 0.00 FALSE
5 GTEx Adipose Visceral Omentum LINC00674 0.29 0.03 enet 40 0.03 6.9e-03 10.6 8.2 2.9e-16 0.63 0.08 0.52 FALSE
6 GTEx Artery Aorta LINC00674 0.12 0.00 lasso 5 0.01 1.5e-01 7.1 9.2 3.6e-20 0.58 0.08 0.33 FALSE
7 GTEx Artery Aorta RP11-147L13.8 0.17 0.10 lasso 6 0.06 4.1e-04 7.1 7.0 3.3e-12 0.46 0.43 0.02 FALSE
8 GTEx Brain Cerebellum BPTF 0.22 -0.01 lasso 10 -0.01 6.9e-01 9.3 -10.3 5.3e-25 -0.85 0.03 0.48 FALSE
9 GTEx Brain Cortex C17orf58 0.34 0.09 lasso 6 0.13 2.4e-04 12.9 12.6 3.1e-36 0.95 0.03 0.96 FALSE
10 GTEx Cells Transformed fibroblasts LINC00674 0.30 0.31 enet 10 0.32 1.5e-24 11.7 11.9 7.6e-33 0.86 1.00 0.00 FALSE
11 GTEx Cells Transformed fibroblasts LRRC37A16P 0.50 0.46 lasso 8 0.47 1.1e-38 11.7 11.9 7.4e-33 0.84 1.00 0.00 FALSE
12 GTEx Cells Transformed fibroblasts SH3GL1P3 0.26 0.31 lasso 7 0.31 1.5e-23 11.7 12.7 1.0e-36 0.90 0.98 0.02 FALSE
13 GTEx Colon Sigmoid LINC00674 0.42 0.09 lasso 8 0.12 5.5e-05 10.6 10.9 7.8e-28 0.80 0.16 0.64 FALSE
14 GTEx Colon Sigmoid RP11-147L13.8 0.12 0.20 lasso 3 0.15 4.4e-06 7.1 7.6 2.5e-14 0.51 0.32 0.51 FALSE
15 GTEx Esophagus Mucosa LRRC37A16P 0.11 0.06 enet 13 0.08 7.5e-06 7.9 -8.4 4.7e-17 -0.67 0.13 0.81 FALSE
16 GTEx Esophagus Muscularis LINC00674 0.11 0.04 lasso 6 0.07 7.9e-05 7.1 10.2 1.8e-24 0.77 0.14 0.83 FALSE
17 GTEx Esophagus Muscularis LRRC37A16P 0.12 0.03 enet 21 0.02 3.2e-02 13.0 9.5 1.6e-21 0.64 0.02 0.82 TRUE
18 GTEx Heart Atrial Appendage LINC00674 0.14 0.08 lasso 17 0.09 1.1e-04 7.0 10.2 1.3e-24 0.73 0.05 0.88 FALSE
19 GTEx Lung LINC00674 0.14 0.03 enet 22 0.08 2.1e-06 12.9 9.5 2.0e-21 0.80 0.11 0.89 TRUE
20 GTEx Muscle Skeletal LRRC37A16P 0.14 0.04 lasso 5 0.08 3.3e-08 7.1 -8.0 1.0e-15 -0.59 0.99 0.00 FALSE
21 GTEx Nerve Tibial LINC00674 0.09 0.01 enet 13 0.03 2.2e-03 7.1 9.0 2.2e-19 0.65 0.21 0.20 FALSE
22 GTEx Nerve Tibial LRRC37A16P 0.09 0.08 lasso 4 0.06 2.7e-05 11.9 12.0 3.6e-33 0.84 0.09 0.81 FALSE
23 GTEx Skin Sun Exposed Lower leg BPTF 0.10 0.01 enet 14 0.03 2.7e-03 10.5 -9.9 6.2e-23 -0.69 0.06 0.75 FALSE
24 GTEx Spleen C17orf58 0.30 -0.01 lasso 8 -0.01 4.6e-01 8.5 12.5 9.3e-36 0.81 0.03 0.34 TRUE
25 GTEx Stomach RP11-147L13.8 0.23 -0.01 enet 9 0.01 8.1e-02 5.3 9.4 5.6e-21 0.57 0.04 0.20 FALSE
26 GTEx Thyroid LINC00674 0.09 0.10 enet 16 0.12 4.0e-09 7.1 7.9 2.3e-15 0.61 0.53 0.43 FALSE
27 GTEx Thyroid SH3GL1P3 0.08 0.00 lasso 3 0.00 2.8e-01 7.1 8.1 4.3e-16 0.56 0.05 0.47 FALSE
28 GTEx Thyroid RP11-147L13.8 0.23 0.17 lasso 3 0.16 3.5e-12 7.1 7.3 2.4e-13 0.49 1.00 0.00 FALSE
29 YFS Blood KPNA2 0.01 0.01 blup 312 0.01 2.8e-04 10.6 -11.3 1.2e-29 -0.86 0.05 0.93 FALSE
30 The Cancer Genome Atlas Bladder Urothelial Carcinoma LOC651250 0.02 0.02 blup 2 0.03 1.9e-03 6.0 -7.6 2.2e-14 -0.51 0.00 0.64 FALSE
31 The Cancer Genome Atlas Breast Invasive Carcinoma LOC651250 0.01 0.01 lasso 1 0.01 1.5e-03 6.0 -6.0 1.7e-09 -0.54 0.00 0.80 FALSE
32 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma LOC651250 0.07 0.05 lasso 1 0.05 1.8e-03 6.0 -6.0 1.7e-09 -0.54 0.00 0.77 FALSE
33 The Cancer Genome Atlas Colon Adenocarcinoma LOC440461 0.22 0.10 blup 10 0.12 2.8e-07 5.3 5.8 5.3e-09 0.17 0.00 1.00 TRUE
34 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma LOC440461 0.11 0.05 lasso 2 0.05 5.1e-04 5.3 5.8 5.7e-09 0.17 0.00 0.84 FALSE
35 The Cancer Genome Atlas Brain Lower Grade Glioma LOC440461 0.22 0.14 lasso 2 0.14 1.1e-15 5.3 5.2 1.8e-07 0.16 0.00 1.00 TRUE
36 The Cancer Genome Atlas Prostate Adenocarcinoma LOC440461 0.06 0.01 blup 10 0.02 2.9e-03 5.3 6.3 3.3e-10 0.19 0.00 0.79 TRUE
37 The Cancer Genome Atlas Prostate Adenocarcinoma LOC651250 0.03 0.02 enet 2 0.02 2.0e-03 6.0 -7.3 2.3e-13 -0.55 0.00 0.77 FALSE
38 The Cancer Genome Atlas Stomach Adenocarcinoma LOC440461 0.10 0.00 blup 10 0.05 2.9e-04 5.3 5.5 3.0e-08 0.20 0.00 0.47 FALSE
39 The Cancer Genome Atlas Thyroid Carcinoma C17orf58 0.02 0.02 lasso 2 0.01 1.8e-02 13.0 13.0 1.1e-38 1.00 0.00 0.76 TRUE