Hub : Genes

RPS6KB1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0380 0.0190 1.8e-03 -0.001 0.009 -0.001 0.010 0.001 4.7e-01 0.0230 0.39000 0.0170 0.26000
2 GTEx Cells Transformed fibroblasts 0.1110 0.0450 6.2e-05 0.069 NA 0.049 NA 0.062 7.3e-06 NA 0.00014 NA 0.00002
3 GTEx Nerve Tibial 0.0474 0.0261 8.6e-03 0.013 NA -0.002 NA 0.004 4.0e-02 NA 0.45000 NA 0.16000
4 GTEx Thyroid 0.1390 0.0620 1.4e-03 0.003 NA 0.020 NA 0.020 1.7e-01 NA 0.01100 NA 0.01100
5 METSIM Adipose 0.0281 0.0151 2.5e-03 0.019 0.014 0.020 0.017 0.022 5.6e-04 0.0027 0.00042 0.0012 0.00024
6 YFS Blood 0.0119 0.0062 1.8e-03 0.011 0.008 0.003 0.006 0.006 1.5e-04 0.0011 0.02400 0.0026 0.00460
7 TCGA Breast Invasive Carcinoma 0.0176 0.0118 5.7e-04 0.020 0.010 0.011 NA 0.012 5.0e-05 0.0036 0.00180 NA 0.00120
8 TCGA Head and Neck Squamous Cell Carcinoma 0.0238 0.0162 5.2e-03 0.020 0.016 0.014 NA 0.013 2.2e-03 0.0063 0.00990 NA 0.01200
9 TCGA Brain Lower Grade Glioma 0.0321 0.0215 4.2e-03 0.024 0.022 0.024 NA 0.020 7.7e-04 0.0013 0.00080 NA 0.00230
10 TCGA Prostate Adenocarcinoma 0.0314 0.0204 1.6e-03 0.029 0.025 0.029 NA 0.026 4.9e-04 0.0010 0.00052 NA 0.00094

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.9 1.4 2.4 1.2 -1.0 -0.9 -0.7 1.5 -1.2 1.3 1.6 0.6 1.4
Bipolar Disorder or Schizophrenia 0.7 1.7 2.9 1.0 -0.7 -1.7 1.7 1.5 -0.2 1.5 1.6 0.3 1.5
Depressed Affect (Nagel 2018) 1.5 3.2 7.5 2.7 -1.1 -0.8 0.3 2.3 0.5 2.3 2.1 -1.2 2.4
Depression (Nagel 2018) 1.1 1.6 2.9 1.1 -0.4 -0.8 0.6 1.7 1.0 1.7 1.3 -1.7 1.7
Intelligence (Savage-Jansen 2018) 2.7 8.3 15.7 -1.4 3.6 3.4 -0.1 -3.6 1.9 -3.2 -4.0 -0.9 -3.6
Neuroticism (Nagel 2018) 1.2 2.8 6.9 2.6 -0.7 -1.1 0.9 2.1 -0.1 2.1 1.8 -1.2 2.2
Schizophrenia (2018) 0.6 1.2 6.9 0.3 -0.1 -1.4 2.6 0.7 0.8 0.9 0.9 -0.1 0.9
Schizophrenia vs Biploar Disorder 1.8 2.4 4.5 -2.1 1.4 1.1 0.6 -1.6 1.6 -1.5 -1.9 -1.7 -1.6
Worry (Nagel 2018) 0.9 1.9 2.8 1.4 -1.4 -1.5 0.6 1.7 -1.4 1.5 1.6 -0.6 1.7
Alzheimer’s Disease (in mother) 1.2 1.5 2.4 -1.1 0.4 1.2 -1.1 -1.6 -0.4 -1.6 -1.3 1.3 -1.5
Alzheimer’s Disease (in father) 2.1 2.3 6.2 -0.5 2.0 1.8 2.2 -1.0 2.5 -0.6 -1.3 -0.2 -1.0
Alzheimer’s Disease (including proxy) 0.8 1.1 2.5 -0.8 0.9 1.6 0.0 -1.2 1.0 -1.1 -1.1 1.0 -1.2
Crohns Disease (2017) 4.4 9.6 14.5 0.7 -3.8 -3.8 -1.6 3.6 -2.8 3.3 3.1 -3.2 3.4
Irritable Bowel Disease (IBD) 4.1 9.7 14.6 1.3 -3.7 -3.8 -0.9 3.8 -2.6 3.8 3.5 -2.2 3.7
Ulcerative Colitis (UC) 2.0 3.7 7.3 1.9 -1.6 -1.8 0.8 2.5 -0.7 2.7 2.5 -0.3 2.5
Major Depression (MDD) 1.9 2.3 10.1 0.1 2.2 1.3 3.2 -0.3 2.3 -0.2 -0.7 -0.6 -0.4
Reaction Time 2.3 4.4 7.5 1.6 -2.2 -2.2 -0.4 2.7 -1.4 2.7 2.7 -0.5 2.7
Verbal and Numeric Reasoning (VNR) 1.5 3.5 6.8 -0.9 2.1 1.9 -1.0 -2.5 1.2 -2.1 -2.6 -0.6 -2.4
Breast Cancer 2.4 5.8 11.2 2.8 0.1 -1.0 2.4 3.1 1.9 3.4 2.7 -1.5 3.1
Ovarian Cancer 1.8 2.3 4.1 -1.5 0.4 1.6 -0.9 -2.0 0.3 -2.0 -1.7 1.5 -2.0
Prostate Cancer 0.9 1.3 2.4 -1.6 -0.6 -1.3 -0.3 -1.2 -1.2 -1.4 -1.2 -0.8 -1.2
Age at First Birth 0.5 0.8 2.0 0.5 1.3 0.7 1.4 -0.7 1.1 -0.6 -0.6 0.6 -0.5
Bipolar Disorder (2011) 0.9 0.9 2.8 0.9 1.3 0.8 1.7 0.4 1.2 0.6 0.3 0.3 0.5
Body Mass Index (BMI) (2010) 0.6 0.8 2.8 -1.6 -0.7 -0.6 -1.7 -0.3 -0.3 -0.4 -0.4 -1.0 -0.4
Coronary Artery Disease (CAD) 3.0 3.6 7.0 2.6 -0.4 -0.6 2.2 2.3 0.0 2.4 2.4 1.0 2.4
Crohns Disease (2012) 5.6 9.0 15.3 1.0 -3.9 -3.5 -2.0 3.6 -2.7 3.2 3.4 -2.0 3.4
Mean Putamen Volume 0.4 0.4 0.7 -0.6 -0.8 -0.2 -0.7 -0.7 -0.8 -0.7 -0.7 -0.3 -0.7
Fasting Glucose 0.4 0.5 3.3 -0.9 0.7 0.1 0.1 0.2 0.7 -0.0 -0.2 -1.8 0.0
HbA1C 5.6 6.2 10.7 1.2 -2.7 -3.0 -0.9 3.2 -1.2 3.2 3.3 -0.7 3.2
HDL Cholesterol 0.3 0.5 1.4 -0.8 -0.2 -0.1 0.0 -0.6 -0.5 -0.8 -0.8 -1.2 -0.7
LDL Cholesterol 0.7 1.1 3.4 0.8 1.6 1.3 1.3 0.2 1.8 0.5 0.0 -0.4 0.3
Lupus 1.7 2.6 4.3 1.8 -1.9 -1.7 -0.4 1.9 -0.9 1.9 2.0 0.2 2.1
Neuroticism (2016) 0.5 0.7 1.7 0.9 -0.2 -0.7 -0.1 1.2 0.1 0.9 0.8 -1.3 1.0
Primary Biliary Cirrhosis 2.5 3.6 5.9 2.2 -1.9 -2.1 -0.4 2.3 -1.0 2.3 2.4 -0.2 2.4
Rheumatoid Arthritis 0.5 0.7 2.9 -1.7 -0.8 -0.3 -1.3 -0.4 -0.9 -0.5 -0.4 -0.2 -0.5
Schizophrenia (2014) 0.7 1.6 9.3 0.4 0.3 -1.4 3.0 0.8 0.9 1.0 0.8 -0.6 0.9
Triglycerides 1.0 1.6 3.4 1.6 -0.3 -0.9 0.6 1.7 -0.2 1.8 1.7 0.1 1.8
Type 2 Diabetes (T2D) (2012) 1.3 1.5 5.4 0.4 1.6 1.4 2.3 -0.5 1.8 -0.2 -0.5 1.1 -0.4
Ulcerative Colitis 3.0 4.4 6.9 2.4 -2.2 -2.0 0.3 2.5 -1.5 2.5 2.6 0.3 2.5
Blood Eosinophil Count 2.0 15.1 57.5 7.6 2.6 3.9 1.9 2.7 2.0 3.4 3.3 5.0 3.1
Blood Platelet Count 2.0 23.1 80.1 -2.1 7.3 8.9 0.9 -4.0 5.6 -3.1 -4.3 1.3 -3.9
Blood Red Count 3.3 31.8 55.5 -3.0 5.3 6.5 0.5 -7.5 3.2 -7.4 -7.1 3.5 -7.4
Blood White Count 11.8 87.2 234.1 0.4 13.2 15.3 5.0 -8.9 9.2 -7.8 -8.2 8.8 -8.2
Heel T-Score 0.1 0.8 1.7 1.0 0.2 0.1 0.4 1.0 -0.1 1.2 1.2 1.3 1.1
BMI 1.0 5.5 14.2 -0.8 -3.8 -3.5 -2.1 2.3 -2.3 1.7 2.2 -1.1 2.0
Height 0.3 5.3 21.3 3.1 -1.1 0.6 -1.8 -1.2 -3.6 -1.2 -0.1 4.6 -1.1
Waist Hip Ratio (WHR) 0.2 1.1 2.5 -0.2 1.4 1.6 1.0 -0.7 1.4 -0.7 -0.6 1.3 -0.7
Systolic Blood Pressure 3.0 14.8 30.8 0.2 -4.9 -5.5 -1.4 4.8 -2.2 4.3 4.8 -0.7 4.6
Smoking Status 1.6 3.9 8.0 -1.9 1.7 1.4 0.5 -2.4 1.0 -2.6 -2.8 -1.5 -2.5
Allergy or Eczema 0.8 2.1 7.8 2.8 0.9 1.1 1.7 0.5 0.5 0.9 0.9 2.5 0.7
Cardiovascular Disease 0.4 1.2 2.5 -0.6 -0.5 -1.4 1.3 1.1 1.6 1.0 0.9 -1.1 1.2
Hypothyroidism (self reported) 0.6 1.4 4.8 -0.3 -2.2 -1.9 -1.7 0.4 -1.3 0.2 0.6 0.2 0.4
Respiratory disease 0.9 1.9 3.9 2.0 -1.5 -1.1 -1.1 1.5 -1.1 1.4 1.6 0.2 1.6
Type 2 Diabetes (T2D) (2018) 0.8 1.6 4.4 -0.4 1.9 1.7 1.6 -0.7 2.1 -0.6 -0.8 0.2 -0.6
Lung FEV1/FVC ratio 1.9 9.6 16.2 2.7 -3.4 -3.1 -0.5 4.0 -2.1 3.9 4.0 -0.5 3.9
Lung FVC 1.2 6.3 14.7 -1.3 1.6 1.9 -0.1 -3.7 0.2 -3.8 -3.4 1.4 -3.7
Neuroticism 2.4 5.7 10.0 2.4 -2.1 -2.2 -0.2 3.2 -1.3 3.0 2.8 -1.9 3.1
Chronotype (morning person) 2.2 5.0 10.7 2.4 -1.3 -1.2 0.0 2.8 -1.1 2.7 3.3 2.4 2.8
Hair Pigment 0.0 1.3 3.0 -0.3 0.4 1.1 -0.5 -1.5 -0.3 -1.7 -1.1 1.6 -1.5
Tanning 0.5 5.8 10.3 2.0 -2.7 -2.5 -0.1 3.0 -1.8 2.8 3.2 0.4 3.0
Hand grip strength (left) 1.6 4.1 8.9 -2.0 1.2 1.5 -0.1 -2.7 -0.4 -2.7 -3.0 -0.9 -2.9
Number of treatments/medications taken 2.5 4.5 9.0 2.4 -0.7 -0.6 1.2 2.9 1.4 3.0 2.9 0.6 3.0
Average weekly spirits intake 0.2 0.3 0.8 -0.7 0.6 0.9 -0.6 -0.2 0.7 -0.3 -0.4 -0.1 -0.3
Sensitivity / hurt feelings 2.2 3.8 12.4 0.4 -2.0 -3.5 0.5 1.8 -1.5 1.7 1.4 -2.9 1.7
Frequency of depressed mood in last 2 weeks 0.9 1.3 9.8 0.0 -0.1 -0.7 -0.3 0.9 0.8 0.8 0.2 -3.1 0.8
Hearing difficulty/problems: Yes 1.6 2.4 8.1 2.8 -0.2 0.0 2.3 1.2 -0.2 1.3 1.6 1.8 1.3
Relative age of first facial hair 1.6 3.2 9.1 0.1 2.9 3.0 0.1 -1.3 2.8 -1.0 -1.4 0.6 -1.3
Other serious medical condition/disability diagnosed by doctor 3.0 3.9 7.2 2.5 -1.5 -1.7 -0.3 2.7 -0.5 2.5 2.7 -0.6 2.6
Ever used hormone-replacement therapy (HRT) 2.0 2.6 5.2 0.9 -2.0 -2.3 1.6 1.7 -0.7 1.4 2.0 0.8 1.8
Ever had hysterectomy (womb removed) 3.2 3.6 5.7 1.9 -2.3 -2.4 -0.2 2.2 -1.7 1.9 2.4 0.1 2.2
Systolic blood pressure, automated reading 4.1 11.8 28.5 0.3 -4.7 -5.3 -1.0 4.0 -2.4 3.5 4.1 -0.8 3.9
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 3.9 0.5 1.6 2.0 1.2 -1.0 1.8 -0.7 -0.9 1.1 -0.8
Angina 1.1 1.4 3.3 1.3 1.1 1.8 1.3 0.8 1.7 0.8 0.8 1.0 0.8
Medication for hormone replacement therapy 0.3 0.3 1.4 -1.2 -0.5 -0.7 0.6 -0.3 -0.1 -0.4 -0.3 -0.4 -0.3
Vitamin and mineral supplements 0.6 0.8 4.1 0.5 -1.1 -0.7 -0.2 -0.1 -2.0 -0.2 0.3 1.2 -0.0
Supplements: Zinc 0.9 1.0 4.0 2.0 -0.5 -0.1 0.2 1.1 0.3 1.3 1.1 0.2 1.1
Medication: Co-codamol 0.8 1.0 1.7 1.2 -1.1 -1.3 -0.6 1.0 -0.4 1.2 1.1 -0.0 1.1
Medication: Metformin 0.5 0.7 2.3 1.5 0.8 1.0 0.5 0.0 0.8 0.3 0.3 1.5 0.2
Diabetes (father) 2.3 2.8 10.6 0.6 2.1 2.4 3.3 -0.3 2.4 0.1 -0.3 1.1 -0.1
Diabetes (mother) 0.1 0.1 0.3 -0.2 0.3 0.2 0.5 -0.3 0.4 -0.2 -0.3 -0.2 -0.2
Severe depression (siblings) 1.8 2.0 5.9 -2.2 1.1 0.5 -0.1 -1.0 1.6 -1.1 -1.5 -2.4 -1.1
Pack years adult smoking proportion 1.5 2.3 11.2 -0.1 -2.5 -1.0 -3.3 0.5 -2.0 0.3 0.7 -0.0 0.4
Impedance of leg (right) 3.0 14.6 30.5 -1.0 5.5 5.5 2.0 -4.0 4.6 -3.4 -4.2 0.7 -3.8
Leg fat-free mass (left) 0.5 2.8 6.2 1.1 -2.4 -1.9 -1.2 1.6 -2.5 1.3 1.8 0.8 1.4
Trunk fat percentage 0.0 0.1 0.3 -0.3 -0.3 -0.2 -0.4 -0.1 0.5 -0.3 0.0 0.5 -0.2
Hand grip strength (right) 1.9 5.1 10.5 -2.1 1.8 2.4 -0.2 -2.9 0.3 -2.9 -3.2 -0.8 -3.1
Townsend deprivation index at recruitment 1.8 2.6 5.2 1.5 -2.1 -2.3 -0.7 1.4 -2.2 1.1 1.7 0.5 1.4
Current tobacco smoking 0.6 0.9 5.5 -1.2 -0.2 -1.3 0.4 0.0 -0.2 -0.1 -0.4 -2.4 -0.0
Average weekly fortified wine intake 1.6 1.9 3.4 -1.7 1.0 1.3 0.4 -1.7 0.7 -1.8 -1.7 0.4 -1.8
Maternal smoking around birth 0.5 0.7 3.0 -0.3 -1.1 -1.7 0.8 0.5 -0.8 0.4 0.6 -0.4 0.5
Fed-up feelings 0.3 0.6 1.2 0.9 0.9 0.7 1.0 -0.2 1.1 -0.1 -0.5 -1.1 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.9 2.6 5.2 0.7 -1.4 -2.0 0.0 2.0 -0.3 1.9 1.7 -2.3 1.9
Relative age voice broke 1.8 2.7 9.8 0.6 3.1 2.7 1.4 -0.7 2.3 -0.3 -1.0 -0.2 -0.7
Taking other prescription medications 5.1 7.9 15.5 3.7 -1.8 -1.6 0.6 3.8 0.0 3.7 3.9 0.5 3.9
Age when periods started (menarche) 0.5 1.2 2.3 -0.3 1.0 1.5 -0.6 -1.4 -0.9 -1.5 -1.3 0.4 -1.3
Bilateral oophorectomy (both ovaries removed) 0.7 0.9 1.6 0.5 -0.4 -1.0 0.1 1.2 0.8 1.2 1.0 -1.0 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.3 -0.5 -0.1 0.2 -0.6 -0.4 0.4 -0.1 -0.6 -0.6 -0.4
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 1.8 -0.4 -0.7 -1.3 -0.2 -0.4 -0.5 -0.5 -0.2 0.4 -0.4
Qualifications: CSEs or equivalent 0.4 0.5 1.0 -0.7 0.4 -0.0 1.0 -0.8 -0.5 -0.9 -0.9 -0.4 -0.8
Serious illness, injury or assault to yourself 0.4 0.5 2.1 0.3 -0.4 0.4 -1.5 -0.4 -0.3 -0.7 -0.2 1.2 -0.5
High blood pressure 1.3 3.5 5.9 1.2 -1.4 -2.3 1.7 2.4 1.1 2.3 2.4 -0.1 2.4
Hayfever, allergic rhinitis or eczema 0.6 1.3 4.5 2.1 1.4 1.2 1.2 -0.1 0.9 0.3 0.2 1.7 0.1
Multivitamins +/- minerals 0.6 0.8 1.8 -0.9 0.9 0.6 0.8 -0.6 1.3 -0.4 -0.9 -1.4 -0.6
Stomach or abdominal pain in last month 0.7 0.8 1.6 1.1 0.0 0.6 -0.8 1.2 0.3 1.2 1.3 0.1 1.3
Supplements: Glucosamine 1.2 1.5 5.3 1.0 2.0 2.1 0.3 -0.4 2.3 -0.3 -0.5 0.4 -0.4
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 3.4 0.9 0.6 0.7 1.8 -0.2 0.9 0.1 -0.1 0.5 -0.0
Medication: Atenolol 3.2 4.0 6.4 2.5 -2.1 -1.4 -0.7 1.9 -2.2 1.7 2.5 2.3 2.0
Medication: Levothyroxine sodium 1.2 2.1 3.8 1.2 -1.8 -1.3 -1.1 1.6 -0.6 1.4 1.9 1.3 1.6
Sitting height 0.4 2.8 13.8 -0.5 -2.5 -2.2 -1.7 -0.1 -3.7 -0.4 0.2 0.0 -0.2
Chronic bronchitis/emphysema (father) 1.7 1.9 9.5 -1.0 -1.1 -2.4 -0.1 0.9 0.0 0.8 0.3 -3.1 0.7
High blood pressure (mother) 2.5 3.5 5.9 0.8 -0.7 -2.1 1.6 2.3 1.1 2.4 1.8 -2.4 2.3
Body mass index (BMI) 0.5 2.2 5.3 -0.2 -2.2 -2.3 -0.6 1.7 -0.9 1.3 1.7 -0.7 1.6
Impedance of leg (left) 2.6 12.5 24.0 -1.2 4.9 4.9 1.5 -3.9 3.8 -3.5 -4.1 0.7 -3.8
Leg predicted mass (left) 0.5 2.8 5.7 1.0 -2.3 -1.9 -1.2 1.6 -2.4 1.3 1.9 0.7 1.5
Trunk fat mass 0.0 0.2 0.6 0.1 -0.7 -0.4 -0.6 0.3 -0.1 0.0 0.4 0.8 0.2
Waist circumference 0.0 0.1 0.4 -0.1 -0.1 -0.2 -0.2 0.3 0.6 0.0 0.2 0.2 0.2
Number of incorrect matches in round 1.4 2.3 4.8 2.2 -0.1 -0.4 1.7 1.8 0.2 1.9 1.9 0.7 2.0
Past tobacco smoking 3.8 7.0 11.3 1.7 -3.1 -2.6 -2.2 3.0 -2.4 3.0 3.4 0.5 3.1
Alcohol usually taken with meals 1.7 2.8 6.5 -1.2 2.5 2.1 1.0 -1.3 2.5 -0.9 -1.7 -1.2 -1.3
Nervous feelings 1.8 3.4 5.2 1.4 -2.0 -2.2 -0.5 2.3 -2.0 2.0 2.0 -1.3 2.1
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.3 3.2 1.2 -1.6 -1.4 -1.3 1.8 -1.0 1.7 1.5 -1.6 1.7
Hearing difficulty/problems with background noise 3.2 5.0 20.3 4.5 1.5 1.7 2.6 1.5 1.4 1.8 1.7 2.3 1.6
Hair/balding pattern: Pattern 2 1.9 2.4 5.0 -0.6 1.5 2.2 -1.7 -1.8 1.1 -1.7 -1.7 0.6 -1.7
Had menopause 0.5 0.6 1.6 0.4 -1.2 -1.3 -0.6 0.4 -0.4 0.1 0.6 1.2 0.4
Had other major operations 0.5 0.6 1.7 0.2 0.7 0.6 -0.5 -1.0 0.3 -1.0 -0.7 1.3 -0.9
Forced vital capacity (FVC) 1.7 6.7 13.4 -0.6 2.0 2.7 -0.4 -3.7 -0.5 -3.7 -3.2 2.2 -3.6
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 2.3 -0.9 -0.3 0.0 -1.5 -0.5 -0.2 -0.4 -0.6 -0.6 -0.5
Ever unenthusiastic/disinterested for a whole week 1.2 1.4 3.4 -0.8 -0.3 -1.1 1.8 1.2 1.1 1.1 0.7 -1.9 1.1
Qualifications: None of the above 3.2 6.9 12.4 2.2 -3.1 -2.7 -0.1 3.2 -2.3 2.8 3.5 1.2 3.2
Financial difficulties in last 2 years 0.4 0.5 1.3 -1.0 0.4 0.4 -0.3 -0.4 1.1 -0.5 -0.7 -1.1 -0.5
Mouth/teeth dental problems 5.1 7.8 17.4 -1.2 4.2 3.9 1.0 -2.8 3.4 -2.5 -3.0 0.9 -2.7
Heart attack 2.1 2.6 6.4 2.5 -0.3 0.0 1.4 1.8 0.4 1.9 2.1 1.6 2.0
Allergy 0.5 1.2 5.5 -2.4 -0.7 -0.9 -0.2 -0.5 -0.9 -0.8 -0.8 -1.5 -0.7
Pain all over the body in last month 0.2 0.2 0.7 0.2 -0.8 -0.4 -0.7 -0.3 -0.4 -0.3 -0.2 0.2 -0.2
Diabetes (self-reported) 0.2 0.4 0.7 0.4 0.7 0.8 -0.1 0.5 0.7 0.5 0.5 0.9 0.5
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 2.7 0.1 1.6 1.2 0.3 -0.3 1.5 -0.1 -0.4 0.4 -0.2
Medication: Ramipril 1.2 1.5 5.5 2.3 -0.6 -0.0 -0.3 1.2 0.5 1.4 1.5 1.3 1.4
Medication: Simvastatin 0.3 0.5 2.7 0.6 0.3 0.5 1.6 0.1 0.3 0.2 0.2 0.9 0.3
Fluid intelligence score 1.9 3.8 7.3 -1.7 2.0 1.9 -1.2 -2.4 1.3 -2.0 -2.7 -1.6 -2.3
Illnesses of siblings 0.7 1.0 1.4 -1.2 1.0 1.1 -1.2 -1.1 0.4 -1.1 -1.2 -0.2 -1.1
Neuroticism score 1.6 3.3 6.3 1.7 -1.6 -1.9 0.2 2.3 -0.8 2.0 1.8 -2.5 2.1
Weight 0.1 0.7 2.0 -0.0 -1.4 -1.1 -1.1 0.6 -1.1 0.3 0.7 0.4 0.5
Impedance of arm (right) 2.8 13.1 25.5 -1.3 5.0 4.6 1.6 -4.2 3.9 -3.6 -4.3 0.7 -4.0
Arm fat percentage (right) 0.0 0.1 0.3 -0.3 -0.2 -0.4 -0.1 0.1 0.6 -0.1 0.1 0.1 0.1
Trunk fat-free mass 0.2 1.3 3.1 0.8 -1.4 -1.1 -1.1 1.1 -1.8 1.0 1.3 0.7 1.0
Hip circumference 0.1 0.5 1.4 -0.6 0.3 0.4 -0.4 -1.0 0.2 -1.2 -0.9 0.4 -1.0
Time employed in main current job 1.8 2.1 6.2 -0.1 -2.5 -2.0 -1.2 1.3 -1.6 0.9 1.3 -0.8 1.2
Alcohol intake versus 10 years previously 0.3 0.4 0.9 0.8 -0.2 -0.6 0.1 0.9 -0.1 0.9 0.9 -0.2 0.9
Father’s age at death 0.4 0.6 1.0 -0.2 0.9 0.9 0.9 -1.0 -0.1 -0.7 -1.0 0.2 -0.9
Worrier / anxious feelings 0.4 0.8 3.2 -0.6 -0.9 -1.8 0.3 0.2 -0.9 0.1 0.0 -1.6 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 4.1 -0.2 1.2 0.9 0.0 -0.1 2.0 -0.0 -0.6 -1.7 -0.1
Falls in the last year 0.2 0.3 0.9 0.3 0.6 0.6 -0.9 0.2 0.9 0.2 0.0 -0.4 0.2
Hair/balding pattern: Pattern 3 1.2 1.7 3.3 1.0 -1.2 -1.8 1.0 1.3 -1.3 1.5 1.6 0.5 1.3
Number of live births 1.4 2.0 3.3 1.4 -1.6 -1.8 0.5 1.4 -1.2 1.3 1.8 1.3 1.6
Forced expiratory volume in 1-second (FEV1) 1.0 3.2 6.3 0.2 1.1 1.9 -0.2 -2.5 -0.7 -2.5 -2.2 1.6 -2.5
Pulse rate 1.0 1.8 3.4 -1.0 0.9 1.1 -0.8 -1.9 1.0 -1.7 -1.8 0.4 -1.8
Happiness 0.4 0.5 2.2 -0.0 -0.4 -0.9 0.1 0.7 0.2 0.7 0.5 -1.5 0.7
Noisy workplace 0.1 0.1 0.6 -0.5 -0.1 0.3 0.1 0.1 0.8 0.2 0.0 -0.3 0.1
Qualifications: A levels/AS levels or equivalent 0.8 1.8 3.1 -1.3 1.8 1.3 -1.3 -1.4 1.0 -1.0 -1.7 -1.0 -1.4
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.6 -0.6 0.4 0.1 0.1 -0.7 0.7 -0.8 -0.7 -0.4 -0.7
Mouth/teeth dental problems: Dentures 6.5 11.0 24.3 1.7 -4.9 -4.6 -1.0 3.3 -4.3 2.8 3.7 0.6 3.2
Asthma 0.7 1.5 4.5 2.1 -1.1 -0.8 -1.1 1.0 -0.8 0.9 1.3 1.1 1.1
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.3 7.4 0.8 1.9 1.0 2.7 0.9 2.7 1.0 0.6 0.1 0.9
Medication: Cholesterol lowering 1.2 1.8 3.5 1.1 1.3 1.4 1.9 1.1 1.6 1.2 1.1 1.4 1.1
Depression (self-reported) 1.2 1.4 6.6 0.3 -0.9 -1.4 0.6 1.1 -0.3 1.1 0.7 -2.6 1.0
Medication: Lansoprazole 0.1 0.1 0.3 0.2 0.2 0.2 0.2 -0.4 0.1 -0.3 -0.2 0.5 -0.3
Prospective memory result 0.6 0.8 3.1 0.2 0.2 0.0 1.8 0.8 0.6 0.6 0.9 1.3 0.7
Lung cancer (father) 0.6 0.7 2.7 -0.1 -1.0 -1.6 0.5 -0.0 -1.6 -0.4 -0.0 -0.7 -0.1
Illnesses of mother 1.1 1.4 8.8 -0.2 -1.4 -0.6 -1.4 -0.3 -3.0 -0.7 -0.1 0.6 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.4 5.7 1.1 1.7 2.4 0.2 -2.2 -0.2 -2.3 -1.9 2.4 -2.2
Pulse wave Arterial Stiffness index 0.4 0.5 1.1 0.9 -0.2 0.3 -0.4 0.8 0.2 0.8 0.9 1.0 0.8
Impedance of arm (left) 2.3 10.6 18.8 -1.2 4.3 4.2 1.5 -3.8 3.7 -3.3 -3.9 0.5 -3.6
Arm fat mass (right) 0.1 0.6 1.5 -0.2 -1.2 -1.2 -0.6 0.8 -0.5 0.5 0.9 0.2 0.7
Trunk predicted mass 0.2 1.2 2.8 0.9 -1.3 -1.0 -0.9 1.1 -1.7 1.0 1.3 0.7 1.0
Standing height 0.3 2.6 5.3 0.7 1.2 2.2 -1.4 -1.8 -0.9 -1.7 -1.4 2.3 -1.8
Length of working week for main job 1.2 1.3 2.4 -0.8 1.5 1.4 0.9 -1.2 1.2 -1.1 -1.2 -0.0 -1.2
Exposure to tobacco smoke at home 1.3 1.4 4.3 -2.1 -0.3 -0.3 -1.7 -1.1 -0.9 -1.4 -1.0 -0.2 -1.2
Breastfed as a baby 0.6 0.7 3.5 -1.4 0.7 -0.1 0.3 -0.2 0.8 -0.1 -0.6 -1.9 -0.3
Tense / ‘highly strung’ 1.2 2.0 4.4 0.8 -1.0 -1.2 0.4 2.1 -0.5 1.9 1.9 -0.9 1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.6 6.9 1.6 -1.4 -2.0 -0.2 2.6 0.0 2.6 2.2 -1.9 2.5
Hair/balding pattern: Pattern 4 0.8 1.9 3.5 1.2 -1.9 -1.8 0.0 1.3 -1.4 1.1 1.7 1.3 1.3
Birth weight of first child 1.4 2.5 4.0 -0.1 -1.7 -2.0 -1.3 1.7 -1.8 1.8 1.7 -1.0 1.7
Peak expiratory flow (PEF) 1.6 3.8 11.3 0.7 2.4 3.4 0.7 -1.9 1.3 -1.8 -1.8 2.1 -1.9
Pulse wave reflection index 0.5 0.6 1.8 1.3 0.7 1.1 0.7 0.3 0.5 0.5 0.5 1.0 0.5
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.8 0.4 -0.6 -0.9 0.8 0.6 -0.7 0.3 0.7 0.7 0.5
Loud music exposure frequency 2.5 2.8 6.2 1.4 -1.4 -1.2 -0.6 2.5 -1.0 2.1 2.3 -0.8 2.3
Qualifications: O levels/GCSEs or equivalent 6.3 10.1 22.8 -0.5 4.8 4.8 0.8 -3.5 2.7 -3.0 -3.7 0.2 -3.4
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.8 0.6 -0.1 0.3 -0.9 -0.2 -0.8 -0.2 -0.1 0.4 -0.2
Blood clot in the leg (DVT) 0.6 0.8 2.4 0.4 0.8 1.6 -0.6 -0.9 0.4 -0.9 -0.7 1.1 -0.8
Medication: Paracetamol 3.1 5.2 9.1 2.8 -1.9 -2.1 0.4 2.9 -1.2 2.9 2.8 -0.9 3.0
Headache pain in last month 2.2 3.7 7.7 2.2 -0.0 -0.2 1.6 2.7 0.5 2.8 2.4 -1.0 2.8
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 1.9 -0.6 -0.3 -0.6 -0.7 -1.3 -1.1 -1.4 -1.4 -1.2 -1.3
Glaucoma (self-reported) 0.5 0.6 1.3 1.1 0.4 0.8 -0.6 0.7 0.1 0.7 0.9 1.0 0.8
Gout (self-reported) 1.1 1.5 4.5 -0.9 -2.1 -1.8 -1.0 0.6 -1.9 0.4 0.6 -0.5 0.5
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 3.3 1.4 -1.8 -1.2 -1.0 1.2 -0.7 1.1 1.5 1.1 1.3
Medication: Amlodipine 0.5 0.7 1.3 -0.2 -1.1 -1.2 -0.8 0.9 0.3 0.8 0.9 -0.2 0.9
Medication: Ventolin 100micrograms inhaler 0.2 0.3 1.2 -0.4 -1.0 -1.1 0.1 0.2 -0.4 0.0 0.1 -0.7 0.2
Birth weight 0.1 0.2 0.6 -0.2 0.8 0.6 -0.5 -0.5 -0.1 -0.4 -0.5 0.1 -0.6
Chronic bronchitis/emphysema (mother) 3.1 3.6 12.7 -0.1 -2.4 -3.6 0.7 1.7 -1.2 1.6 1.5 -2.3 1.7
High blood pressure (siblings) 0.2 0.3 1.5 0.9 0.3 -0.2 1.2 0.0 0.4 0.3 0.1 0.2 0.1
Forced vital capacity (FVC), Best measure 1.8 6.5 11.5 0.2 2.5 3.0 0.3 -3.4 0.3 -3.4 -3.0 2.5 -3.4
Body fat percentage 0.0 0.1 0.8 -0.4 -0.1 -0.0 -0.1 -0.2 0.9 -0.4 -0.1 0.4 -0.2
Leg fat percentage (right) 0.1 0.5 2.4 -0.4 0.6 0.6 0.5 -0.5 1.5 -0.6 -0.4 0.5 -0.5
Arm fat-free mass (right) 0.6 3.3 6.2 1.1 -2.5 -2.0 -1.2 1.9 -2.4 1.6 2.1 0.7 1.8
Exposure to tobacco smoke outside home 1.2 1.6 7.1 -1.3 -1.3 -2.1 -0.7 0.5 -0.4 0.1 0.1 -2.7 0.2
Comparative body size at age 10 0.4 1.2 3.0 0.8 -0.7 -0.1 -0.1 1.7 0.5 1.7 1.6 -0.1 1.6
Number of full brothers 0.1 0.2 0.4 0.2 0.5 0.3 0.3 -0.6 0.2 -0.5 -0.6 -0.1 -0.5
Worry too long after embarrassment 0.5 0.8 2.5 0.5 1.4 0.6 0.4 -0.4 1.6 -0.4 -0.8 -1.4 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 2.2 2.9 6.2 0.9 -0.3 -1.0 0.6 2.4 1.0 2.5 1.9 -2.1 2.3
Wheeze or whistling in the chest in last year 0.6 1.1 3.0 1.4 -1.1 -1.0 -1.1 0.7 -1.7 0.3 1.0 0.6 0.8
Number of children fathered 0.4 0.5 2.2 -0.2 0.4 1.5 -0.1 -0.7 0.3 -0.7 -0.6 0.8 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 2.3 2.7 5.0 0.4 2.1 1.9 2.2 -1.3 2.2 -1.0 -1.1 2.0 -1.1
Age at first live birth 0.6 1.1 2.5 1.2 -0.0 1.4 -1.6 0.5 -0.4 0.8 0.8 1.6 0.7
Pulse wave peak to peak time 0.4 0.5 1.1 -0.7 0.2 -0.1 0.2 -0.9 -0.3 -0.9 -1.0 -0.8 -1.0
Health satisfaction 0.2 0.2 1.0 -1.0 -0.1 -0.3 -0.2 0.4 0.5 0.3 0.2 -0.7 0.3
Shortness of breath walking on level ground 1.0 1.2 2.4 1.5 -1.4 -0.3 -0.5 1.0 -1.6 0.7 1.2 1.2 0.9
Qualifications: College or University degree 0.8 2.4 6.6 -1.1 2.6 2.4 -0.5 -1.2 1.8 -0.7 -1.5 -1.2 -1.2
Eye problems/disorders: None of the above 0.2 0.2 1.0 -0.5 0.4 -0.1 -0.4 -0.5 0.2 -0.2 -0.6 -1.0 -0.4
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.5 0.4 -0.3 -0.6 -0.1 0.5 -0.3 0.4 0.4 -0.7 0.4
Emphysema/chronic bronchitis 2.1 2.4 6.2 0.4 -2.2 -1.9 -2.5 1.0 -2.0 0.7 1.4 1.0 0.9
Medication for pain relief, constipation, heartburn 2.1 3.6 9.1 -3.0 -0.1 -0.0 -1.1 -2.5 -0.9 -2.5 -2.4 -0.5 -2.5
Neck or shoulder pain in last month 1.4 2.0 6.0 1.8 2.1 2.4 1.3 0.1 1.9 0.3 -0.0 0.4 0.3
Medication: Blood pressure 0.5 0.9 2.2 -0.0 -0.7 -0.5 0.2 1.4 0.5 1.3 1.5 1.0 1.3
Angina (self-reported) 1.3 1.7 3.3 1.4 1.2 1.7 1.6 1.0 1.8 1.1 1.0 0.6 1.1
Migraine (self-reported) 0.5 0.7 3.8 -1.0 0.2 -0.4 -0.0 -0.4 0.8 -0.2 -0.7 -1.9 -0.4
Medication: Ibuprofen 1.5 1.8 7.2 0.1 2.0 1.2 2.3 0.3 2.7 0.4 0.1 0.4 0.3
Medication: Allopurinol 0.6 0.8 2.7 0.1 -1.6 -1.2 -0.0 0.7 -1.4 0.6 0.8 0.6 0.7
Medication: Omeprazole 0.3 0.3 1.6 0.5 -0.2 0.2 -0.3 0.5 0.2 0.5 0.7 1.3 0.5
Medication: Seretide 50 evohaler 1.7 2.0 6.3 -0.8 -2.5 -2.3 -1.3 1.1 -1.1 0.8 1.1 -0.9 1.0
Mean time to correctly identify matches 3.0 5.7 9.2 1.4 -2.9 -2.6 -1.2 2.9 -2.0 2.9 3.0 -0.2 2.9
Heart disease (mother) 1.7 2.1 6.7 1.3 2.0 1.4 1.9 0.3 2.6 0.7 0.4 1.4 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.9 -0.5 0.8 0.0 1.4 -0.2 0.7 -0.1 -0.4 -0.4 -0.3
Whole body fat mass 0.1 0.3 0.7 0.1 -0.8 -0.7 -0.4 0.5 -0.1 0.3 0.7 0.6 0.4
Leg fat mass (right) 0.0 0.1 0.3 0.1 -0.4 -0.2 0.0 0.4 0.3 0.2 0.5 0.5 0.3
Arm predicted mass (right) 0.6 3.1 5.8 0.9 -2.4 -2.1 -1.1 1.9 -2.3 1.6 2.0 0.2 1.7
Pulse rate, automated reading 0.4 1.4 4.2 -2.0 0.0 -0.5 -1.0 -1.4 -0.3 -1.4 -1.5 -0.5 -1.4
Alcohol intake frequency. 3.7 8.5 23.7 -0.4 -4.8 -4.9 -2.3 2.0 -4.1 1.5 2.1 -1.5 1.9
Comparative height size at age 10 1.0 5.6 17.9 4.1 -1.7 0.1 -1.6 1.5 -1.9 1.5 2.4 4.2 1.7
Number of full sisters 0.9 1.1 6.4 -0.8 0.4 -0.9 2.5 -0.5 0.9 -0.5 -0.6 -1.1 -0.4
Suffer from ‘nerves’ 1.0 1.6 3.9 2.0 -0.9 -0.5 -0.6 1.4 -1.7 1.3 1.3 -0.7 1.4
Overall health rating 3.3 7.1 13.2 2.4 -3.0 -2.8 -1.5 3.3 -1.4 3.0 3.6 0.7 3.4
Chest pain or discomfort 0.8 1.2 4.8 0.4 1.5 1.1 0.9 0.6 2.2 0.8 0.3 -1.1 0.7
Had major operations 0.5 0.5 2.2 -0.7 0.4 -0.6 1.5 -0.8 0.6 -0.7 -0.7 0.1 -0.6
Age at last live birth 1.1 1.6 3.3 1.6 -0.8 0.3 -1.2 1.2 -0.9 1.2 1.6 1.8 1.3
Family relationship satisfaction 0.2 0.2 0.6 -0.8 0.4 0.1 -0.1 -0.5 0.5 -0.8 -0.6 -0.2 -0.5
Leg pain on walking 0.5 0.6 1.8 -0.6 1.1 0.7 0.4 -0.6 1.4 -0.5 -0.8 -0.6 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.4 0.1 -0.2 -0.8 1.2 -0.3 -1.1 0.0 -0.1 0.5 -0.2
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.0 0.1 0.7 1.4 -0.1 -0.7 0.8 -0.9 -0.5 1.2 -0.7
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 0.9 0.8 -0.3 -0.2 1.0 0.7 -0.8 0.9 0.9 0.8 0.8
Medication: Aspirin 1.7 2.3 6.0 2.4 0.3 1.5 -0.6 1.2 1.0 1.4 1.6 2.3 1.3
Supplements: Vitamin C 0.5 0.6 4.1 0.1 1.1 0.9 0.1 -0.1 2.0 0.2 -0.2 0.1 0.0
Knee pain experienced in last month 0.6 0.9 3.7 -0.2 0.6 0.1 0.6 0.8 1.5 0.8 0.3 -1.9 0.7
Hypertension (Self-reported) 1.0 2.7 4.5 1.1 -0.9 -1.6 1.7 2.1 1.4 2.0 2.1 -0.0 2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 3.8 1.1 0.5 0.8 0.5 0.1 0.4 0.3 0.5 1.9 0.3
Illnesses of father: Heart disease 2.1 3.0 9.1 1.6 2.1 2.1 2.8 -0.1 3.0 0.3 0.0 1.3 0.2
Illnesses of siblings: Diabetes 0.2 0.3 0.7 0.7 -0.9 -0.5 0.8 0.3 -0.5 0.4 0.4 0.5 0.3
Smoking status: Previous 2.1 3.2 5.5 -1.0 1.8 1.9 1.2 -2.2 1.4 -2.3 -2.3 0.2 -2.3
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.2 3.7 -0.1 0.8 1.5 -0.5 -1.9 -1.4 -1.8 -1.6 1.9 -1.9
Whole body fat-free mass 0.4 2.5 5.6 1.0 -2.1 -1.7 -1.3 1.5 -2.4 1.2 1.7 0.7 1.4
Leg fat-free mass (right) 0.7 3.7 10.0 0.9 -2.8 -2.4 -1.6 1.6 -3.2 1.2 1.9 0.8 1.4
Arm fat percentage (left) 0.0 0.1 0.4 -0.2 -0.6 -0.6 0.1 0.4 0.5 0.2 0.4 0.1 0.3
Average weekly red wine intake 1.4 2.0 3.7 1.3 1.0 0.7 1.9 1.5 1.5 1.9 1.5 0.7 1.6
Handedness (chirality/laterality): Left-handed 2.0 2.5 5.6 -1.5 0.7 0.2 -0.6 -2.2 -0.2 -2.2 -2.4 -1.0 -2.2
Mood swings 0.7 1.2 4.4 0.9 -1.4 -1.3 -0.5 1.0 -0.2 0.9 0.7 -2.1 1.0
Loneliness, isolation 0.8 1.2 3.1 1.7 0.1 0.4 0.2 1.3 1.2 1.4 1.2 -0.0 1.4
Long-standing illness, disability or infirmity 5.7 8.7 13.5 2.7 -3.5 -3.5 -0.1 3.5 -2.1 3.4 3.7 -0.4 3.6
Ever had bowel cancer screening 3.1 3.6 6.4 1.7 -2.2 -2.5 -0.3 2.1 -1.6 2.1 2.4 0.5 2.2
Diabetes diagnosed by doctor 0.3 0.4 2.2 0.0 0.8 1.1 -0.1 -0.2 0.4 -0.1 0.0 1.5 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 4.5 -0.3 2.1 1.4 0.9 -1.0 1.6 -0.8 -1.2 -0.2 -1.0
Friendships satisfaction 0.5 0.6 1.5 0.6 0.8 -0.4 1.2 0.6 1.2 0.5 0.3 -1.0 0.6
Qualifications: nursing, teaching 1.1 1.7 3.1 -1.4 1.5 1.7 -0.9 -1.1 1.7 -1.0 -1.4 -0.6 -1.2
Commuting to job workplace: Walk 1.6 1.8 3.8 1.4 1.1 -0.1 1.9 1.2 1.7 1.6 0.9 -1.2 1.3
Eye problems/disorders: Cataract 0.4 0.5 1.4 -1.2 -0.9 -0.3 -0.6 -0.4 -0.8 -0.8 -0.4 0.3 -0.6
Mouth/teeth dental problems: Mouth ulcers 1.6 2.5 11.3 -1.3 -2.0 -2.3 -0.6 0.8 -1.1 0.6 0.3 -3.4 0.6
Medication for cholesterol 3.2 4.8 8.2 -2.5 2.5 2.3 -1.0 -2.4 1.2 -2.1 -2.9 -1.9 -2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.4 2.8 10.0 3.2 -1.0 -0.0 -0.8 0.8 -2.3 0.9 1.4 2.7 0.9
Back pain experienced in last month 1.8 2.7 8.7 2.9 -0.7 -0.3 1.1 1.7 -0.4 1.6 2.1 1.8 1.8
Mineral and other dietary supplements 0.4 0.5 2.5 -0.2 -0.9 -0.5 0.7 -0.4 -1.6 -0.4 -0.2 0.5 -0.3
Breast cancer (self-reported) 0.2 0.3 0.6 -0.2 0.7 0.8 -0.4 -0.3 0.5 -0.5 -0.5 -0.1 -0.5
Asthma (self-reported) 0.6 1.1 3.7 1.9 -0.9 -0.6 -1.3 0.8 -0.6 0.7 1.1 1.1 0.9
Osteoporosis (self-reported) 1.3 1.7 4.7 -0.7 -1.5 -1.3 -2.2 1.3 -0.6 1.2 1.1 -1.2 1.2
Osteoarthritis (self-reported) 1.2 1.5 2.9 1.4 -0.8 -0.8 0.6 1.7 0.8 1.6 1.6 -0.4 1.7
Medication: Aspirin 1.6 2.0 7.1 2.3 0.4 1.5 -0.5 0.9 0.9 1.0 1.3 2.7 1.0
Medication: Gliclazide 1.3 1.5 7.3 1.6 1.4 0.5 2.7 0.5 1.1 0.8 0.4 0.4 0.7
Illnesses of father: None of the above (group 1) 1.6 2.0 7.7 -0.8 -1.7 -1.2 -2.6 -0.3 -2.8 -0.6 -0.2 -0.5 -0.3
Smoking status: Current 0.5 0.8 4.9 -1.3 0.2 -0.9 0.4 -0.3 -0.0 -0.4 -0.7 -2.2 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 2.6 -0.2 1.6 1.3 1.0 -1.4 0.9 -1.3 -1.3 1.3 -1.4
Whole body water mass 0.5 2.7 5.9 0.9 -2.2 -1.8 -1.4 1.6 -2.4 1.3 1.8 0.7 1.4
Leg predicted mass (right) 0.8 4.0 10.7 0.9 -3.0 -2.5 -1.7 1.7 -3.3 1.3 1.9 0.7 1.5
Arm fat mass (left) 0.2 0.8 1.8 0.3 -1.4 -1.3 -0.3 1.1 -0.5 0.8 1.2 0.3 1.0
Number of self-reported non-cancer illnesses 2.8 4.9 9.5 2.6 -1.2 -1.1 0.6 2.9 1.5 3.0 3.1 0.8 3.1
Average weekly champagne plus white wine intake 2.9 4.0 11.1 -0.4 3.2 3.3 0.8 -1.6 2.7 -1.4 -1.8 0.6 -1.7
Miserableness 3.4 5.9 11.6 3.0 -0.9 -1.0 0.6 3.4 1.0 3.4 2.8 -2.3 3.3
Guilty feelings 1.0 1.5 3.2 -0.8 1.4 1.2 -0.3 -1.2 1.8 -1.2 -1.5 -1.3 -1.2
Wears glasses or contact lenses 0.6 0.7 2.8 0.6 1.3 1.3 0.3 0.3 1.7 0.5 0.2 0.0 0.4
Ever taken oral contraceptive pill 2.8 3.1 5.0 -1.8 2.2 2.2 -0.1 -1.9 1.8 -1.8 -2.1 -0.1 -2.0
Hearing aid user 1.8 2.0 5.0 2.2 -0.7 -0.2 1.0 1.4 -0.8 1.4 1.8 2.0 1.4
Mother’s age at death 2.6 3.3 7.7 0.6 2.8 2.6 1.9 -1.6 2.4 -1.0 -1.6 0.8 -1.4
Financial situation satisfaction 3.4 4.2 10.4 -2.9 2.4 1.3 1.7 -1.5 3.2 -1.4 -1.9 -1.8 -1.4
Tinnitus: Yes, now most or all of the time 1.3 1.6 5.7 0.2 1.4 1.8 2.4 -0.6 1.7 -0.6 -0.7 0.5 -0.6
Commuting to job workplace: Public transport 0.9 1.1 2.3 0.3 -0.6 -1.5 -0.1 1.1 -0.5 1.5 0.9 -1.5 1.2
Eye problems/disorders: Glaucoma 0.5 0.6 2.3 0.5 0.8 1.5 -0.1 0.2 0.3 0.2 0.4 1.4 0.3
Medication: Blood pressure 2.3 4.5 7.8 2.6 -2.0 -2.4 0.7 2.6 -0.1 2.4 2.8 0.6 2.6
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.9 1.1 0.8 1.0 1.0 0.8 1.4 0.8 0.5 -0.6 0.8
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.4 0.6 0.6 -0.1 0.4 1.1 1.6 1.1 1.0 -0.2 1.1
High cholesterol (Self-reported) 0.3 0.5 1.4 -0.6 1.2 1.0 0.9 0.1 1.2 0.4 -0.0 -0.0 0.2
Medication: Bendroflumethiazide 0.1 0.2 1.0 -0.2 -0.7 -0.5 -1.0 -0.1 -0.0 -0.2 -0.1 -0.4 -0.2
Medication: Paracetamol 3.1 4.8 8.4 2.5 -1.8 -2.1 0.9 2.8 -1.0 2.7 2.7 -1.2 2.9
Medication: Lisinopril 1.8 2.3 4.2 1.4 0.2 0.4 0.9 2.0 1.8 2.0 2.0 0.7 2.0
Medication: Atorvastatin 1.1 1.3 7.2 0.4 0.9 2.0 -0.1 -0.4 0.7 -0.4 0.0 2.7 -0.4
Illnesses of father: High blood pressure 0.2 0.3 0.6 0.6 0.4 0.6 0.2 0.3 0.7 0.5 0.4 0.8 0.3
Alcohol drinker status: Never 2.3 2.8 5.1 0.6 -2.3 -2.0 -1.6 1.9 -1.3 1.6 1.7 -1.4 1.8
Ever smoked 3.6 6.3 9.6 -2.3 3.1 2.0 2.4 -2.6 2.7 -2.4 -3.1 -1.5 -2.6
Basal metabolic rate 0.4 2.0 4.5 0.8 -2.0 -1.6 -1.2 1.3 -2.1 1.1 1.5 0.6 1.2
Leg fat percentage (left) 0.0 0.2 0.6 -0.4 0.0 0.1 0.1 -0.3 0.8 -0.5 -0.2 0.6 -0.3
Arm fat-free mass (left) 0.4 2.2 4.2 1.0 -2.0 -1.6 -1.3 1.5 -2.1 1.2 1.7 0.8 1.3
Number of operations (self-reported) 0.2 0.4 1.6 -0.2 0.6 -0.1 1.0 -0.3 1.3 -0.3 -0.1 0.5 -0.2
Average weekly beer plus cider intake 0.6 0.9 3.8 0.3 -1.0 -0.9 -0.3 -0.5 -1.3 -0.8 0.1 2.0 -0.4
Irritability 1.8 3.0 5.3 2.2 -0.9 -1.4 0.5 2.3 -0.9 2.2 2.0 -1.5 2.2
Risk taking 0.5 0.7 2.2 -0.9 -1.5 -1.4 -0.6 0.2 -1.2 0.1 0.3 -0.4 0.1
Ever had prostate specific antigen (PSA) test 0.3 0.4 2.6 0.4 0.3 -0.1 1.6 0.3 0.5 0.7 0.2 -0.0 0.4
Fractured/broken bones in last 5 years 1.7 2.2 4.5 -0.8 1.4 1.4 -0.1 -2.0 0.4 -2.0 -2.1 -0.4 -2.0
Age started oral contraceptive pill 1.4 1.8 5.0 2.2 -0.9 -0.4 -0.1 1.1 -0.5 1.1 1.6 2.2 1.3
Diastolic blood pressure, automated reading 1.4 4.3 10.3 -0.4 -2.9 -3.2 -1.4 2.3 -1.7 1.8 2.4 -0.6 2.2
Ever depressed for a whole week 1.3 1.6 7.0 -1.0 -1.1 -2.0 1.1 0.9 -0.1 0.6 0.3 -2.6 0.7
Unable to work because of sickness or disability 2.2 2.8 6.0 0.5 -2.4 -2.5 -1.1 1.8 -1.7 1.6 1.8 -0.9 1.6
Commuting to job workplace: Cycle 0.8 0.9 3.7 0.2 -0.5 -0.9 -1.2 0.9 -0.6 0.9 0.5 -1.9 0.8
Myopia 0.3 0.5 1.5 -0.3 1.0 1.2 -0.2 -0.5 0.8 -0.3 -0.7 -0.5 -0.5
Vascular/heart problems diagnosed by doctor 1.4 3.9 7.1 -1.5 1.0 1.6 -1.7 -2.6 -1.4 -2.6 -2.6 -0.2 -2.7
Cholesterol lowering medication 0.4 0.5 4.0 0.7 -0.4 0.5 -0.1 -0.1 -0.6 -0.0 0.3 2.0 -0.0
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.5 0.1 0.3 0.6 -0.2 0.1 0.7 0.1 0.2 0.7 0.1
Pain experienced in last month 2.2 3.7 9.4 -3.1 0.1 0.3 -1.9 -2.3 -0.7 -2.5 -2.2 0.5 -2.5
Supplements: Calcium 0.5 0.6 1.4 1.0 0.6 1.0 0.5 0.7 1.2 0.6 0.5 -0.4 0.6
Basal cell carcinoma (self-reported) 1.1 1.4 3.2 -0.5 0.8 0.1 0.8 -1.7 -0.1 -1.8 -1.6 0.6 -1.7
Heart attack/myocardial infarction (self-reported) 2.1 2.7 6.6 2.6 -0.4 -0.1 1.2 1.9 0.3 2.0 2.2 1.5 2.1
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.4 0.7 0.7 1.5 -0.6 -0.8 0.2 -0.8 -0.6 1.3 -0.7
Heart disease (siblings) 1.8 2.2 6.5 2.5 -0.5 -0.6 1.2 1.7 0.0 1.9 1.8 0.6 1.8
Alcohol drinker status: Previous 0.4 0.5 1.3 0.5 -0.2 -0.7 1.1 0.8 0.1 0.8 0.8 -0.4 0.9
Pack years of smoking 1.7 2.5 9.9 0.1 -2.6 -1.2 -3.1 0.6 -2.2 0.4 0.9 0.3 0.6
Impedance of whole body 2.5 12.6 22.6 -1.3 4.8 4.7 1.4 -4.1 3.8 -3.6 -4.2 0.6 -3.9
Leg fat mass (left) 0.0 0.1 0.4 0.1 -0.6 -0.4 -0.1 0.4 -0.1 0.1 0.5 0.6 0.3
Arm predicted mass (left) 0.5 2.3 5.3 0.8 -2.1 -1.7 -1.5 1.4 -2.3 1.1 1.6 0.7 1.2