Best TWAS P=1.01e-14 · Best GWAS P=7e-17 conditioned to 2.84e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | NTR | Blood | FPR2 | 0.10 | 0.08 | bslmm | 611 | 0.08 | 5.6e-24 | 6.11 | -6.3 | 2.7e-10 | 0.03 | 1.00 | 0.00 | FALSE |
2 | YFS | Blood | FPR2 | 0.56 | 0.40 | lasso | 10 | 0.50 | 1.2e-192 | 6.11 | -6.7 | 1.8e-11 | 0.07 | 1.00 | 0.00 | FALSE |
3 | YFS | Blood | FPR3 | 0.15 | 0.05 | bslmm | 596 | 0.10 | 2.2e-32 | -0.27 | -6.2 | 7.2e-10 | 0.04 | 1.00 | 0.00 | FALSE |
4 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CD33 | 0.10 | 0.01 | enet | 18 | 0.06 | 2.0e-04 | 4.93 | 5.3 | 1.1e-07 | 0.02 | 0.08 | 0.24 | TRUE |
5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SIGLEC5 | 0.14 | 0.00 | blup | 73 | 0.03 | 7.2e-03 | -5.85 | -5.7 | 1.2e-08 | 0.44 | 0.02 | 0.49 | FALSE |
6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SIGLEC5 | 0.12 | 0.00 | lasso | 4 | 0.02 | 3.5e-03 | 2.93 | -5.2 | 2.4e-07 | 0.41 | 0.03 | 0.67 | FALSE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | FPR3 | 0.05 | 0.01 | lasso | 4 | 0.02 | 2.7e-03 | 6.16 | -7.7 | 1.6e-14 | -0.02 | 0.08 | 0.13 | FALSE |
8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FPR3 | 0.05 | 0.03 | blup | 97 | 0.02 | 1.0e-03 | -4.88 | -7.4 | 1.4e-13 | 0.11 | 0.03 | 0.18 | FALSE |
9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SIGLEC5 | 0.06 | 0.01 | blup | 73 | 0.03 | 3.8e-04 | -5.85 | -6.5 | 9.7e-11 | 0.35 | 0.03 | 0.73 | TRUE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FPR3 | 0.17 | 0.10 | lasso | 2 | 0.07 | 9.7e-04 | -4.88 | -5.3 | 1.2e-07 | 0.10 | 0.07 | 0.06 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SIGLEC14 | 0.17 | 0.05 | lasso | 4 | 0.10 | 6.3e-11 | -6.26 | -6.1 | 1.3e-09 | 0.41 | 0.59 | 0.40 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SIGLEC5 | 0.15 | 0.05 | blup | 73 | 0.08 | 3.9e-09 | 3.41 | -6.0 | 1.6e-09 | 0.40 | 0.12 | 0.86 | FALSE |
13 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FPR3 | 0.07 | 0.00 | blup | 97 | 0.00 | 1.9e-01 | -4.88 | -7.7 | 1.0e-14 | 0.06 | 0.02 | 0.11 | TRUE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | SIGLEC14 | 0.17 | 0.04 | enet | 16 | 0.08 | 4.6e-08 | 2.93 | -6.3 | 2.8e-10 | 0.32 | 0.62 | 0.27 | TRUE |