TWAS hub - CD33

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.1690	0.0540	1.4e-03	0.046	NA	0.002	NA	0.013	4.4e-05	NA	1.8e-01	NA	2.2e-02
2	YFS	Blood	0.1646	0.0215	0.0e+00	0.091	0.093	0.122	0.11	0.109	2.7e-28	1.1e-28	1.2e-37	4e-34	7.7e-34
3	TCGA	Breast Invasive Carcinoma	0.0859	0.0273	3.1e-14	0.083	0.075	0.082	NA	0.089	1.6e-16	5.1e-15	2.5e-16	NA	1.0e-17
4	TCGA	Glioblastoma Multiforme	0.1250	0.0630	4.8e-03	0.082	0.072	0.027	NA	0.056	1.8e-03	3.3e-03	5.1e-02	NA	8.4e-03
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0559	0.0239	1.1e-04	0.009	0.034	0.026	NA	0.023	2.6e-02	8.8e-05	5.2e-04	NA	1.3e-03
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.1052	0.0365	2.5e-09	0.017	0.068	0.074	NA	0.067	4.8e-03	3.9e-08	1.0e-08	NA	4.9e-08
7	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1000	0.0450	1.2e-03	0.007	0.055	0.062	NA	0.032	1.3e-01	4.1e-04	2.0e-04	NA	6.3e-03
8	TCGA	Brain Lower Grade Glioma	0.1731	0.0505	5.6e-17	0.032	0.158	0.156	NA	0.139	1.3e-04	1.6e-17	2.2e-17	NA	1.8e-15
9	TCGA	Lung Adenocarcinoma	0.0601	0.0246	4.5e-05	0.032	0.037	0.033	NA	0.023	1.1e-04	3.0e-05	9.0e-05	NA	8.5e-04
10	TCGA	Lung Squamous Cell Carcinoma	0.0472	0.0217	3.8e-04	0.061	0.032	0.050	NA	0.056	1.7e-07	1.5e-04	2.4e-06	NA	5.1e-07
11	TCGA	Ovarian Serous Cystadenocarcinoma	0.0760	0.0340	6.1e-04	0.013	0.043	0.007	NA	0.028	4.5e-02	7.0e-04	1.0e-01	NA	5.0e-03
12	TCGA	Prostate Adenocarcinoma	0.1118	0.0365	1.2e-08	0.083	0.094	0.074	NA	0.080	4.9e-09	5.2e-10	3.8e-08	NA	1.0e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Alzheimer’s Disease (including proxy)	6.4	9.4	20.8	4.5	4.4	4.6	-0.4	2.1	1.1	4.3	0.8	2.3	4.3	-1.4	1.3
Hearing difficulty/problems with background noise	5.6	8.9	14.6	2.5	3.0	2.8	2.8	3.7	3.8	2.7	3.1	2.4	2.5	3.0	3.1
Supplements: Vitamin C	5.5	6.5	11.6	2.6	3.4	3.2	1.3	2.9	2.2	3.4	2.0	2.5	2.7	0.7	2.1
Primary Biliary Cirrhosis	3.5	5.0	8.4	1.9	1.7	1.9	2.8	2.4	2.9	0.2	2.8	1.6	1.9	2.9	2.5
Pain experienced in last month	3.5	5.9	16.1	2.0	2.6	2.2	1.4	2.6	2.2	1.7	2.7	4.0	2.1	1.8	2.9
Heart attack/myocardial infarction (self-reported)	3.5	4.6	11.2	-2.5	-2.7	-2.4	-0.7	-1.4	-2.1	-3.4	-1.1	-2.1	-2.4	-1.1	-2.1
Blood White Count	3.4	25.0	50.6	7.0	5.6	6.9	2.1	4.4	4.8	6.1	1.8	1.5	7.1	1.5	5.3
Had menopause	3.3	4.1	8.5	-2.0	-0.9	-2.0	-2.0	-2.0	-2.7	-1.4	-1.9	-1.0	-2.2	-2.3	-2.9
Blood Platelet Count	3.2	37.2	82.6	9.0	7.4	9.0	0.6	4.3	4.1	7.6	1.8	3.9	9.1	0.2	5.9
Heart attack	3.2	4.1	10.1	-2.5	-2.6	-2.4	-0.5	-1.2	-1.9	-3.2	-0.9	-2.0	-2.4	-1.0	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.2	3.8	8.0	-2.7	-2.7	-2.8	0.5	-0.8	-0.8	-2.5	-0.8	-2.3	-2.7	0.7	-0.9
Lung cancer (father)	3.1	3.6	6.0	1.7	1.8	1.8	1.7	1.9	1.8	1.6	1.9	2.3	1.6	1.8	2.5
Age started oral contraceptive pill	3.1	3.9	6.3	-2.5	-2.4	-2.5	-1.5	-2.1	-2.4	-1.2	-2.0	-0.7	-2.5	-1.3	-1.7
Alzheimer’s Disease (in mother)	2.9	3.4	7.8	2.5	2.6	2.7	0.1	1.4	0.8	2.8	0.8	1.3	2.4	-0.6	1.1
Pulse wave Arterial Stiffness index	2.8	3.3	6.7	1.0	2.3	1.6	1.7	2.4	1.5	2.1	1.9	2.6	0.9	1.1	1.8
Pulse wave peak to peak time	2.7	3.2	6.3	-1.0	-2.2	-1.5	-1.7	-2.3	-1.5	-2.0	-1.9	-2.5	-0.9	-1.2	-1.9
Eye problems/disorders: Cataract	2.7	3.1	5.4	-1.7	-2.3	-1.9	-1.0	-1.8	-1.8	-2.0	-1.9	-2.0	-1.6	-1.0	-1.5
Average weekly fortified wine intake	2.5	2.9	5.6	-1.1	-1.7	-1.3	-2.2	-1.8	-2.0	-0.9	-2.4	-1.6	-1.1	-1.9	-1.8
Mother’s age at death	2.4	2.9	5.7	-2.4	-2.0	-2.4	-0.5	-1.5	-1.6	-1.6	-1.0	-1.6	-2.3	-0.7	-1.8
Bipolar Disorder (2018)	2.3	3.7	8.9	0.7	0.6	0.8	2.7	2.8	3.0	-0.0	2.5	-0.0	0.8	2.6	2.4
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	9.0	1.2	1.8	1.4	1.1	1.5	1.5	1.9	1.7	3.0	1.1	1.3	1.8
Hearing aid user	2.3	2.6	6.2	-1.7	-1.1	-1.5	-1.9	-1.9	-2.5	0.0	-1.9	0.0	-1.8	-1.4	-1.4
Hearing difficulty/problems: Yes	2.2	3.4	6.2	1.0	1.4	1.3	2.0	2.4	2.4	1.5	1.9	1.5	1.0	2.5	2.4
Length of working week for main job	2.2	2.5	6.2	1.3	-0.0	1.0	2.1	1.5	2.5	-0.2	2.0	0.6	1.2	2.3	1.9
Medication: Co-codamol	2.1	2.4	5.0	-2.0	-2.0	-2.0	-0.9	-1.4	-1.2	0.0	-1.8	-2.2	-1.9	-0.8	-0.6
Commuting to job workplace: Car/motor vehicle	2.1	2.4	7.8	0.0	-0.5	-0.1	-2.2	-1.7	-2.1	0.7	-2.1	-1.3	-0.0	-2.8	-1.6
Medication: Aspirin	2.1	2.7	4.5	-2.1	-2.1	-2.0	-0.5	-1.4	-1.8	-1.4	-1.6	-1.8	-2.0	-0.8	-1.4
Pulse wave reflection index	2.0	2.4	4.7	1.2	1.6	1.7	1.2	2.2	1.3	1.8	1.5	1.8	1.3	0.8	1.8
Angina	1.8	2.3	5.7	-2.3	-1.8	-2.0	-0.8	-1.2	-1.9	-0.4	-1.4	-0.9	-2.4	-0.7	-0.8
Medication: Aspirin	1.8	2.4	4.1	-2.0	-1.9	-1.8	-0.5	-1.2	-1.7	-1.3	-1.5	-1.6	-1.9	-0.8	-1.4
Myopia	1.7	2.4	5.5	-2.0	-0.4	-1.8	2.4	1.0	1.3	-0.5	2.1	0.2	-2.0	2.2	0.3
Medication: Amlodipine	1.6	2.2	3.9	1.9	1.6	2.0	0.9	1.6	1.5	1.9	1.2	1.0	1.9	0.7	1.1
Number of full brothers	1.6	2.0	3.9	1.7	1.5	2.0	1.0	1.8	1.4	0.8	1.4	1.2	1.7	0.6	1.2
Angina (self-reported)	1.6	2.1	5.3	-2.2	-1.8	-2.0	-0.6	-1.1	-1.6	-0.4	-1.3	-0.9	-2.3	-0.4	-0.8
Age at First Birth	1.5	2.1	4.5	-0.9	-0.9	-1.1	-1.9	-1.7	-1.9	0.2	-2.1	-1.3	-1.0	-1.7	-1.5
Blood Eosinophil Count	1.5	11.4	28.3	5.0	4.0	5.0	-0.2	2.1	1.7	5.3	0.3	1.5	4.9	-0.7	3.0
Medication: Atenolol	1.5	1.9	3.5	-1.6	-1.1	-1.4	-1.0	-1.1	-1.8	-0.8	-1.9	-1.4	-1.6	-1.2	-1.3
Back pain experienced in last month	1.5	2.2	6.8	-0.7	-1.5	-0.9	-1.6	-1.6	-1.5	0.1	-2.4	-2.6	-0.7	-1.5	-1.0
Number of operations (self-reported)	1.5	2.2	3.4	1.7	1.8	1.8	1.0	1.5	1.2	1.7	1.1	1.1	1.7	0.7	1.8
Other serious medical condition/disability diagnosed by doctor	1.4	1.9	2.8	-1.6	-1.6	-1.5	-0.9	-1.1	-1.6	-0.5	-1.5	-1.7	-1.5	-1.1	-1.5
Financial difficulties in last 2 years	1.4	1.9	5.4	-1.2	-1.8	-1.5	-0.8	-1.5	-1.1	-1.5	-1.3	-2.3	-1.2	-0.5	-0.9
Migraine (self-reported)	1.4	1.7	3.1	-0.4	-1.2	-0.9	-1.3	-1.8	-1.3	-1.6	-1.2	-1.5	-0.6	-1.5	-1.7
Loneliness, isolation	1.4	2.0	6.5	-0.0	0.2	0.1	2.6	2.0	2.0	-0.1	1.9	-0.5	-0.1	1.8	1.5
Supplements: Zinc	1.3	1.4	2.6	1.4	1.5	1.6	0.9	1.3	0.6	1.1	1.2	1.1	1.4	-0.2	1.0
Mouth/teeth dental problems	1.3	2.1	6.4	0.7	-0.0	0.2	-2.5	-1.6	-0.9	1.2	-2.5	-1.2	0.8	-2.0	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	4.7	2.0	0.7	1.6	0.1	0.1	1.0	1.5	0.5	0.8	2.2	0.4	1.4
Diabetes (father)	1.2	1.5	3.4	1.1	1.1	1.2	1.1	1.5	1.8	0.7	1.4	0.6	1.1	1.0	1.2
Qualifications: CSEs or equivalent	1.2	1.5	5.6	2.2	1.2	2.1	0.0	0.4	0.9	0.6	0.7	0.3	2.4	-0.1	0.1
Pain all over the body in last month	1.2	1.3	3.8	-1.6	-0.7	-1.2	2.0	1.2	0.4	-0.5	1.0	-0.3	-1.5	1.2	1.1
Ever highly irritable/argumentative for 2 days	1.2	1.4	3.2	-1.1	-1.8	-1.3	-0.9	-1.4	-1.3	-1.0	-1.4	-1.4	-1.1	-0.4	-0.2
Health satisfaction	1.2	1.6	3.5	-0.7	-1.1	-0.6	-1.2	-1.2	-1.6	-0.3	-1.9	-1.7	-0.6	-1.7	-1.5
Had major operations	1.2	1.4	3.5	1.3	1.2	1.5	0.6	1.0	1.4	1.9	0.9	0.2	1.4	0.6	1.1
Osteoporosis (self-reported)	1.2	1.5	3.8	-1.9	-1.6	-2.0	-0.4	-0.8	-1.0	-0.9	-0.8	-1.0	-1.8	-0.0	0.1
Eye problems/disorders: Glaucoma	1.2	1.4	3.0	0.2	1.0	0.5	1.5	1.7	1.4	0.6	1.7	1.4	0.2	1.4	1.0
Unable to work because of sickness or disability	1.2	1.6	3.4	1.6	1.0	1.4	0.6	1.0	1.6	1.5	0.9	0.3	1.6	0.7	1.8
Lupus	1.1	1.7	4.3	-1.3	-2.0	-1.5	-0.7	-1.0	-0.5	0.2	-1.3	-2.1	-1.3	-1.0	-1.4
Townsend deprivation index at recruitment	1.1	1.5	3.2	1.5	1.5	1.7	0.4	1.5	1.0	1.8	0.5	0.4	1.6	-0.1	0.9
Exposure to tobacco smoke at home	1.1	1.2	2.6	1.6	1.2	1.5	0.3	0.4	0.7	1.5	0.3	0.9	1.6	0.5	1.1
Exposure to tobacco smoke outside home	1.1	1.5	2.5	1.3	1.4	1.5	0.5	1.4	1.0	1.6	0.9	0.9	1.5	0.3	1.3
Wears glasses or contact lenses	1.1	1.2	2.9	-1.3	-0.9	-1.4	-0.4	-0.8	-1.0	-1.0	-0.6	-1.2	-1.4	-0.9	-1.7
Commuting to job workplace: Public transport	1.1	1.3	2.9	-1.6	-1.2	-1.5	1.0	0.1	0.6	-1.6	0.8	-0.9	-1.7	1.1	-0.1
Mean Putamen Volume	1.0	1.1	2.5	-0.4	0.2	-0.4	-1.1	-1.1	-1.4	-1.0	-1.2	-1.0	-0.5	-1.5	-1.6
LDL Cholesterol	1.0	1.6	5.6	0.2	-0.6	-0.0	1.8	1.3	2.4	-0.7	1.5	-0.4	0.2	2.1	1.2
Average weekly spirits intake	1.0	1.2	4.1	1.0	1.6	1.3	0.5	1.0	1.0	2.0	1.0	0.8	1.2	0.4	0.5
Multivitamins +/- minerals	1.0	1.2	3.1	-0.2	-0.4	-0.4	-1.8	-1.2	-1.5	0.2	-1.6	-1.0	-0.2	-1.7	-0.9
Headache pain in last month	1.0	1.7	4.0	0.2	-0.6	0.1	-1.7	-1.1	-1.3	-0.3	-2.0	-1.8	0.3	-1.9	-1.9
Shortness of breath walking on level ground	1.0	1.2	6.0	0.2	-0.4	0.2	1.6	1.0	0.8	0.9	0.8	0.0	0.2	1.5	2.4
Number of full sisters	1.0	1.2	4.5	1.1	0.5	0.9	0.6	0.6	0.8	1.8	0.7	0.6	1.0	0.9	2.1
Major Depression (MDD)	0.9	1.1	2.1	0.7	-0.2	0.7	1.5	1.3	1.5	-0.9	1.2	-0.3	0.8	1.1	1.4
HDL Cholesterol	0.9	1.5	4.2	-1.2	-0.9	-1.0	-1.0	-1.0	-2.0	-1.1	-1.6	-0.5	-1.3	-1.1	-1.4
Ever used hormone-replacement therapy (HRT)	0.9	1.2	1.8	-1.2	-1.3	-1.4	-0.8	-1.2	-1.1	-0.8	-0.8	-0.9	-1.3	-0.9	-1.3
Severe depression (siblings)	0.9	1.0	2.1	-1.1	-1.2	-1.1	-0.4	-0.8	-0.9	-1.4	-1.0	-1.5	-1.0	-0.7	-0.6
Maternal smoking around birth	0.9	1.3	3.1	-0.1	-0.1	-0.1	-1.8	-1.5	-1.7	-0.2	-1.5	-0.5	-0.0	-1.7	-1.2
Serious illness, injury or assault to yourself	0.9	1.1	2.6	-0.8	-1.2	-0.8	-0.4	-0.8	-1.0	-1.6	-1.0	-1.4	-0.8	-0.6	-1.5
Happiness	0.9	1.1	2.9	-0.1	0.1	-0.0	-1.3	-1.0	-1.5	0.7	-1.3	-0.7	-0.2	-1.7	-1.6
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.7	-1.6	-1.2	-1.4	1.3	0.2	-0.2	-0.5	1.2	-0.1	-1.6	1.2	0.9
Medication: Ventolin 100micrograms inhaler	0.9	1.2	3.4	1.1	1.3	1.6	0.4	1.9	0.4	1.1	0.7	1.2	1.1	-0.3	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.0	1.3	1.2	1.3	0.9	1.4	1.0	0.6	1.0	0.9	1.2	0.5	1.2
Neck or shoulder pain in last month	0.9	1.3	3.6	-1.2	-1.3	-1.3	0.2	-0.7	-0.0	-1.9	-0.1	-1.5	-1.4	0.1	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	5.4	-0.9	-1.8	-1.0	0.5	-0.2	-0.2	-2.3	0.4	-1.5	-1.0	0.1	-1.5
Supplements: Fish oil (including cod liver oil)	0.9	1.1	2.3	-1.2	-0.8	-1.1	-0.3	-1.1	-1.2	-1.3	-0.7	-1.0	-1.3	-0.8	-1.5
Average weekly beer plus cider intake	0.9	1.3	2.5	1.4	1.3	1.3	0.2	0.8	1.6	1.6	0.3	0.5	1.5	0.7	1.5
Alzheimer’s Disease (in father)	0.8	0.9	3.4	0.6	0.9	0.8	-1.0	0.1	-0.7	0.4	-0.7	-0.5	0.5	-1.8	-1.6
Coronary Artery Disease (CAD)	0.8	1.0	2.3	-0.9	-0.9	-0.8	-0.9	-1.5	-1.0	-0.7	-0.9	-1.1	-1.1	-0.8	-1.0
Fasting Glucose	0.8	0.9	2.0	0.4	0.3	1.3	1.3	1.0	1.3	-0.1	1.3	0.2	1.4	0.6	0.7
Neuroticism (2016)	0.8	1.2	2.7	0.7	0.1	0.8	1.4	1.4	1.6	-0.2	1.3	0.3	0.8	1.7	1.2
Ulcerative Colitis	0.8	1.1	3.7	1.2	0.4	0.9	0.4	0.7	1.0	1.3	0.4	1.0	1.1	1.1	1.9
Taking other prescription medications	0.8	1.3	3.4	0.1	-0.2	0.1	-1.4	-0.9	-1.2	1.5	-1.7	-1.1	0.1	-1.9	-1.0
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.4	1.1	0.1	1.1	0.4	1.1	1.2	0.7	0.5	0.6	1.2	0.9	1.6
Hair/balding pattern: Pattern 2	0.8	1.0	3.3	1.0	0.7	1.1	0.6	1.0	0.6	1.4	0.5	0.7	1.0	0.8	1.8
Falls in the last year	0.8	1.1	3.4	1.1	1.8	1.3	0.4	1.0	0.6	1.8	0.4	1.0	1.0	0.0	0.7
Birth weight	0.8	1.7	2.4	-1.4	-1.5	-1.3	-1.2	-1.1	-1.6	-0.5	-1.4	-1.2	-1.5	-1.2	-1.5
Mean time to correctly identify matches	0.8	1.5	6.7	1.5	1.7	1.4	-0.4	0.4	0.7	2.6	0.4	0.7	1.4	-0.6	0.2
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.6	-0.6	-0.5	-0.5	1.8	1.0	1.0	-0.8	1.0	0.1	-0.6	1.9	0.4
Bipolar Disorder or Schizophrenia	0.7	1.7	3.6	-0.6	-1.2	-0.7	1.7	1.5	1.6	-0.8	1.3	-0.9	-0.7	1.9	1.7
Type 2 Diabetes (T2D) (2018)	0.7	1.2	3.7	0.3	-1.0	-0.1	-1.7	-1.6	-1.0	0.9	-1.9	-1.1	0.3	-1.0	-0.5
Number of treatments/medications taken	0.7	1.2	3.1	-0.9	-1.0	-0.8	-0.8	-0.9	-1.4	0.3	-1.8	-1.7	-0.9	-1.1	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.7	1.6	0.7	1.1	-0.6	-0.3	0.5	1.6	-0.7	-0.8	1.5	-0.4	0.6
Number of incorrect matches in round	0.7	1.1	3.2	1.8	1.3	1.6	0.2	0.4	0.9	1.1	0.5	0.4	1.7	0.3	0.5
Alcohol intake versus 10 years previously	0.7	1.1	2.7	1.6	1.2	1.5	-0.6	0.1	-0.0	1.3	-0.7	0.4	1.6	-0.3	1.0
Father’s age at death	0.7	0.9	2.3	-1.4	-0.5	-1.4	-0.3	-1.1	-0.8	-1.1	-0.2	0.4	-1.5	0.0	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.2	0.7	0.6	1.0	1.3	1.5	1.0	0.9	1.3	0.7	0.7	0.9	1.3
Medication for pain relief, constipation, heartburn	0.7	1.2	3.0	1.5	1.7	1.4	-0.4	0.3	0.0	0.9	0.5	1.5	1.5	-0.9	0.1
Ever had bowel cancer screening	0.7	0.8	2.7	-0.2	0.6	-0.3	1.6	0.4	0.8	-0.6	1.6	0.8	-0.4	1.4	0.2
Commuting to job workplace: Walk	0.7	0.7	1.7	-0.8	-0.4	-0.5	1.2	0.8	0.7	-1.2	1.1	0.6	-0.6	1.3	0.5
Mineral and other dietary supplements	0.7	0.9	1.4	0.9	0.9	0.9	0.6	1.1	1.2	0.5	0.9	1.1	1.0	1.0	1.2
Miserableness	0.7	1.3	3.3	1.8	1.5	1.8	-0.2	0.6	0.5	1.3	0.0	0.5	1.8	-0.3	0.5
Ever taken oral contraceptive pill	0.7	0.8	2.1	0.5	-0.8	0.6	1.1	1.4	1.3	0.1	0.7	-0.7	0.6	0.7	1.1
Medication: Bendroflumethiazide	0.7	1.1	2.5	-0.9	-1.3	-0.9	-1.0	-1.1	-1.2	-0.4	-1.6	-1.0	-1.0	-1.0	-0.6
Illnesses of father: High blood pressure	0.7	0.8	2.6	1.5	1.0	1.6	0.0	1.2	1.0	0.3	0.2	-0.0	1.3	-0.4	-0.1
Ever smoked	0.7	1.3	4.6	0.3	-0.1	0.7	1.7	2.1	1.7	0.3	1.1	-0.2	0.5	1.2	1.2
Diastolic blood pressure, automated reading	0.7	2.3	5.4	0.5	1.0	0.8	2.3	2.3	2.2	1.4	1.7	0.2	0.4	1.7	1.5
Ever had hysterectomy (womb removed)	0.6	0.7	2.7	-0.6	-0.9	-0.6	-0.5	-0.7	-0.5	-0.8	-0.8	-1.7	-0.5	-0.8	-0.9
Medication: Metformin	0.6	0.9	1.5	1.1	1.1	1.1	0.4	0.5	0.9	0.9	0.2	0.8	1.1	1.1	1.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.0	1.0	-0.3	0.6	-1.4	-1.1	-0.7	0.0	-1.2	-0.5	1.0	-1.1	-0.4
Illnesses of siblings	0.6	0.9	2.5	0.8	0.7	0.8	-1.6	-0.7	-0.8	-0.0	-1.0	0.4	0.8	-1.5	-0.8
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.2	-0.9	-1.5	-1.3	-1.3	-1.5	-1.4	-0.8	-1.3	-0.5	-1.0	-0.7	-0.7
Asthma	0.6	1.1	3.1	1.0	1.2	1.4	-0.1	1.8	0.2	1.6	-0.0	0.3	1.1	-0.8	0.8
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.4	-1.4	-0.9	-1.3	0.1	0.3	-0.4	0.1	-0.1	-0.9	-1.6	-0.2	-0.7
Qualifications: College or University degree	0.6	1.8	6.6	-1.2	-1.0	-1.1	-1.3	-1.5	-2.6	-1.0	-1.1	-0.2	-1.3	-1.6	-0.9
Medication: Blood pressure	0.6	1.0	3.1	-0.6	-0.5	-0.5	1.8	1.4	1.0	-1.1	0.8	-1.3	-0.6	1.0	0.1
Medication: Gliclazide	0.6	0.7	1.6	-0.2	-0.1	-0.2	-0.9	-0.8	-1.1	-0.5	-1.1	-1.0	-0.2	-1.3	-1.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.3	0.2	0.3	0.4	1.5	0.9	1.1	0.3	1.2	0.1	0.3	1.3	0.9
Supplements: Calcium	0.6	0.6	1.8	0.9	0.8	0.9	-0.7	-0.1	-0.3	1.0	-0.6	-0.4	1.0	-1.4	-0.5
Heart disease (siblings)	0.6	0.8	2.2	0.4	0.4	0.3	1.5	0.7	0.9	-0.4	1.4	0.5	0.3	1.4	1.0
Schizophrenia (2018)	0.5	1.1	4.0	-1.3	-2.0	-1.6	0.2	-0.3	-0.3	-0.8	-0.2	-1.2	-1.6	0.4	0.3
Crohns Disease (2017)	0.5	1.1	2.1	-1.4	-1.2	-1.3	-0.7	-1.0	-1.5	0.3	-1.1	-0.7	-1.4	-0.6	-0.1
Breast Cancer	0.5	1.2	2.8	1.3	1.7	1.6	0.1	0.9	0.0	1.6	0.5	1.5	1.3	-0.3	0.6
Bipolar Disorder (2011)	0.5	0.5	2.1	0.0	0.0	-1.4	0.0	0.0	0.3	-0.7	0.9	-0.2	0.0	1.4	0.7
Crohns Disease (2012)	0.5	0.7	2.0	-1.3	-0.2	-1.0	-0.7	-0.3	-1.4	0.4	-0.9	-0.4	-1.3	-0.9	-0.2
Relative age of first facial hair	0.5	1.1	2.0	1.1	0.6	0.9	0.7	0.6	1.4	1.3	0.9	0.7	1.2	1.2	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.5	1.2	0.4	1.0	-0.6	0.1	0.1	1.6	-0.4	-0.3	1.2	-0.6	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	3.0	-0.0	-0.6	-0.0	-0.8	-0.7	-1.1	0.2	-1.2	-1.7	-0.1	-1.6	-0.7
Hair/balding pattern: Pattern 3	0.5	0.7	1.9	-0.6	-0.9	-0.8	-0.5	-0.7	-0.5	-1.2	-0.8	-1.2	-0.6	-0.4	-1.4
Mouth/teeth dental problems: Dentures	0.5	0.8	2.6	-0.4	0.8	-0.2	1.2	0.7	0.6	-0.6	1.6	1.3	-0.5	1.0	0.4
Depression (self-reported)	0.5	0.6	2.9	-0.3	-1.0	-0.4	-0.4	-0.6	-0.6	-0.5	-0.3	-1.7	-0.3	-0.9	-0.8
Hair/balding pattern: Pattern 4	0.5	1.1	2.5	-1.4	0.1	-0.8	1.6	1.2	0.5	-0.4	1.5	0.7	-1.3	1.2	0.6
Medication: Omeprazole	0.5	0.6	1.4	-1.1	-1.2	-1.0	0.7	0.3	0.1	-0.9	-0.0	-0.7	-1.1	1.0	0.2
Medication: Seretide 50 evohaler	0.5	0.5	1.3	0.6	0.5	0.8	-0.3	0.3	-0.6	1.1	-0.8	-0.7	0.5	-1.1	-0.8
Heart disease (mother)	0.5	0.6	2.0	-0.5	-0.7	-0.3	1.4	0.8	0.7	-0.5	1.1	-0.4	-0.6	0.7	0.5
Pulse rate, automated reading	0.5	1.7	3.8	0.1	0.8	0.3	1.7	1.6	1.4	1.2	1.4	1.4	-0.0	1.9	1.9
Age at last live birth	0.5	0.7	3.8	-0.7	-0.2	-0.5	1.0	0.9	0.8	-1.9	1.1	-0.3	-0.5	0.6	-0.4
Mood swings	0.5	1.0	3.2	1.5	0.8	1.2	-0.7	-0.2	0.4	1.8	-0.3	0.1	1.5	-0.1	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.8	1.3	0.6	1.3	0.0	0.7	0.8	0.2	0.1	-0.3	1.3	-0.1	0.3
Asthma (self-reported)	0.5	1.0	3.1	0.9	1.0	1.4	-0.2	1.6	0.2	1.8	-0.1	0.3	0.9	-0.8	0.9
Average weekly champagne plus white wine intake	0.5	0.7	2.1	-0.5	-0.0	-0.1	1.4	1.5	0.8	-0.2	1.4	0.6	-0.4	0.8	0.5
Irritability	0.5	0.8	3.2	0.6	0.0	0.2	0.9	0.3	1.5	-0.2	0.9	0.2	0.5	1.8	1.2
Fractured/broken bones in last 5 years	0.5	0.6	1.9	0.6	0.0	0.6	-1.3	-0.6	-1.0	0.1	-0.9	-0.2	0.6	-1.4	-0.8
Reaction Time	0.4	0.8	3.1	1.2	1.1	1.1	-0.4	0.2	0.5	1.8	0.3	0.4	1.1	-0.4	0.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.7	-0.4	0.4	-0.3	1.5	1.0	0.8	-0.1	1.5	0.9	-0.5	1.6	1.1
HbA1C	0.4	0.4	2.7	0.4	-0.9	0.3	0.0	0.4	0.7	0.3	-0.1	-1.6	0.6	-0.3	-0.4
Schizophrenia (2014)	0.4	0.8	2.0	-0.6	-1.4	-0.9	0.7	0.2	1.0	-0.5	0.4	-1.3	-0.7	1.0	1.1
Triglycerides	0.4	0.6	2.3	0.0	-0.1	-0.1	1.1	0.4	1.5	0.1	1.4	0.2	0.0	1.3	0.4
Systolic Blood Pressure	0.4	1.9	3.7	0.9	0.9	1.0	1.9	1.4	1.8	0.2	1.7	0.9	0.8	1.9	1.7
Hypothyroidism (self reported)	0.4	0.8	2.2	-1.5	-0.9	-1.3	0.3	-0.7	-0.6	-0.2	-0.3	-1.1	-1.5	-0.2	-1.0
Neuroticism	0.4	1.0	2.7	1.1	0.1	0.9	0.9	0.9	1.6	0.1	0.5	-0.8	1.2	1.2	1.3
Chronotype (morning person)	0.4	0.9	2.4	1.6	0.6	1.5	-1.0	-0.3	-0.5	0.2	-0.8	-0.0	1.5	-1.3	-0.5
Systolic blood pressure, automated reading	0.4	1.2	3.3	0.1	0.8	0.4	1.8	1.7	1.3	1.1	1.2	0.7	-0.1	1.4	1.0
Current tobacco smoking	0.4	0.7	2.1	1.4	0.8	1.4	-0.1	0.5	0.9	0.1	0.4	-0.3	1.4	-0.1	-0.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.9	0.9	0.5	0.8	0.9	0.3	0.9	0.3	0.6	-0.4	0.8	0.7	0.3
High blood pressure (mother)	0.4	0.6	1.6	-0.0	-1.2	-0.5	-0.5	-1.1	-0.1	-1.2	-0.5	-1.1	-0.1	0.3	-1.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.1	0.9	0.7	1.1	-0.2	0.3	-0.6	0.6	-0.1	1.0	1.0	-0.7	-0.2
Medication: Ramipril	0.4	0.5	1.3	0.2	0.8	0.6	1.0	0.9	0.1	0.6	0.7	1.2	0.3	0.5	0.3
Fluid intelligence score	0.4	0.7	1.9	-0.8	0.3	-0.7	1.0	0.7	0.4	-0.1	1.1	1.2	-0.8	1.4	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.8	-0.2	-0.9	-0.5	0.5	0.3	1.1	-0.7	0.2	-0.9	-0.3	1.3	0.9
Prospective memory result	0.4	0.5	2.1	-1.2	-0.7	-1.1	0.4	-0.1	-0.1	0.7	-0.0	-0.3	-1.4	0.6	0.0
Illnesses of mother	0.4	0.5	1.4	0.7	0.7	0.6	-1.1	-0.2	-0.4	0.2	-1.2	-0.3	0.8	-1.1	-0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.0	-1.4	-0.9	-1.2	0.3	-0.4	-0.6	-0.7	-0.4	-0.7	-1.4	-0.0	-0.9
Comparative body size at age 10	0.4	1.1	3.6	-0.9	-1.5	-0.9	0.6	-0.3	-0.2	-1.9	-0.3	-1.8	-0.8	0.5	-1.1
Worry too long after embarrassment	0.4	0.7	2.4	0.8	-0.2	0.6	1.0	0.8	1.6	-0.3	0.6	-1.1	0.9	0.8	0.8
Wheeze or whistling in the chest in last year	0.4	0.7	1.7	1.0	0.6	1.3	0.4	1.3	0.9	0.5	0.3	-1.2	1.1	-0.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.3	0.4	0.5	0.1	0.5	0.4	0.8	0.4	0.7	0.7	0.4	0.9	1.5
Age at first live birth	0.4	0.7	3.8	-0.9	-0.4	-0.8	0.6	0.6	0.2	-2.0	0.8	0.0	-0.9	0.3	-0.8
Eye problems/disorders: None of the above	0.4	0.5	1.4	0.8	1.1	0.8	-0.5	0.1	0.4	1.1	0.3	1.2	0.8	-0.1	0.2
Emphysema/chronic bronchitis	0.4	0.4	1.3	-1.1	-0.7	-0.9	0.5	0.2	0.1	-0.5	-0.0	-0.8	-1.1	0.4	-0.4
Medication: Ibuprofen	0.4	0.5	1.5	0.8	-0.3	0.5	0.4	0.4	1.1	-0.1	0.2	-0.7	0.7	0.9	1.2
Chest pain or discomfort	0.4	0.6	2.3	0.7	0.2	0.9	-0.9	0.3	-0.8	0.9	-0.8	-0.7	0.5	-1.5	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	1.0	0.9	0.8	-0.1	0.3	0.7	0.7	0.1	0.9	1.0	0.7	0.8
Smoking status: Previous	0.4	0.5	2.0	-1.0	-1.4	-0.9	0.4	0.2	-0.1	-0.8	-0.3	-0.8	-1.0	0.2	-0.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.2	-0.4	-1.1	-0.4	-0.3	-0.3	-1.0	-0.9	-0.4	-1.0	-0.6	-0.9	-0.7
Osteoarthritis (self-reported)	0.4	0.5	1.4	0.0	-1.0	-0.3	-1.1	-1.0	-0.4	-0.2	-1.2	-0.7	0.1	-0.4	-0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	2.0	-0.7	-1.4	-1.0	0.1	-0.5	-0.2	-0.7	0.1	-0.7	-0.7	-0.0	-0.5
High cholesterol (Self-reported)	0.4	0.8	2.4	-0.1	0.7	0.1	1.2	0.5	0.8	0.7	0.8	1.4	-0.2	1.5	1.1
Commuting to job workplace: Cycle	0.4	0.5	1.5	0.4	0.6	0.6	0.6	0.9	0.1	0.8	0.5	0.9	0.5	0.5	1.2
Cholesterol lowering medication	0.4	0.6	1.3	-0.8	-0.6	-0.7	-0.4	-1.0	-1.0	0.1	-1.2	-0.1	-0.7	-0.3	-1.0
Basal cell carcinoma (self-reported)	0.4	0.5	1.6	1.3	0.6	1.0	-0.2	-0.0	0.1	1.1	-0.2	-0.5	1.1	-0.4	0.3
Depression (Nagel 2018)	0.3	0.4	1.2	1.1	0.1	0.6	-0.5	-0.7	0.5	0.4	-0.5	-0.7	1.1	-0.0	-0.0
Ulcerative Colitis (UC)	0.3	0.6	2.8	0.2	0.2	0.2	0.5	0.8	0.6	0.8	0.6	0.7	0.1	1.1	1.7
Prostate Cancer	0.3	0.4	1.0	0.3	-1.0	0.1	-0.8	-1.0	-0.5	-0.1	-0.9	-0.9	0.3	-0.2	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.7	0.8	-0.1	0.7	-0.6	-0.0	-0.3	1.3	-0.6	-0.6	0.8	-0.7	0.1
Blood Red Count	0.3	2.6	4.9	0.4	1.8	0.8	1.7	1.9	1.6	2.2	1.8	1.8	0.3	1.6	2.2
Respiratory disease	0.3	0.7	3.8	0.2	0.2	0.6	0.8	1.9	0.6	1.1	0.4	0.3	0.2	0.4	1.3
Tanning	0.3	4.0	7.8	2.2	1.9	2.2	2.0	2.0	2.8	1.0	2.3	1.1	2.1	1.8	1.9
Medication for hormone replacement therapy	0.3	0.4	1.1	0.0	0.0	-0.3	-1.0	-1.0	-0.4	1.0	-0.9	-0.0	0.1	-0.6	0.3
Vitamin and mineral supplements	0.3	0.3	1.1	-0.4	-0.1	-0.4	0.9	0.2	0.5	-0.7	0.8	0.5	-0.3	1.1	0.3
Stomach or abdominal pain in last month	0.3	0.3	1.5	0.1	-0.2	-0.0	-0.6	-0.4	-0.4	-0.2	-1.2	-1.2	0.1	-0.5	-0.2
Had other major operations	0.3	0.4	1.4	-0.7	-0.9	-0.7	0.2	0.0	-0.2	-1.2	-0.6	-0.8	-0.7	0.2	0.0
Hip circumference	0.3	1.1	4.4	-1.3	-1.1	-1.0	0.4	0.3	-0.4	-0.8	-0.8	-2.1	-1.3	-0.4	-1.3
Pulse rate	0.3	0.5	1.5	0.1	0.4	-0.1	0.7	0.0	0.5	0.1	0.7	1.2	0.1	1.2	1.2
Noisy workplace	0.3	0.4	1.3	0.4	0.6	0.4	0.4	0.2	0.2	0.9	0.1	0.9	0.5	0.7	1.1
Medication: Cholesterol lowering	0.3	0.4	1.4	0.1	0.6	0.2	1.1	0.5	0.7	0.1	0.7	0.4	0.0	1.2	0.9
Blood clot in the leg (DVT)	0.3	0.3	0.7	0.5	0.3	0.7	0.8	0.6	0.5	0.5	0.7	-0.0	0.6	0.6	0.6
High blood pressure (siblings)	0.3	0.5	1.0	-0.8	-1.0	-0.6	0.9	1.0	0.3	0.1	0.5	-0.7	-0.9	0.4	0.0
Number of children fathered	0.3	0.3	0.9	0.7	0.3	0.5	-0.7	-0.2	-0.2	0.8	-0.5	0.2	0.6	-0.3	1.0
Medication: Allopurinol	0.3	0.4	1.2	-0.9	-1.1	-0.9	0.0	-0.6	-0.0	-1.0	-0.2	0.1	-0.8	0.4	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.8	0.7	0.7	0.9	0.1	0.7	0.2	0.8	0.1	0.2	0.8	-0.4	0.1
Alcohol intake frequency.	0.3	0.6	2.1	0.4	-0.1	0.3	-1.2	-0.7	-1.0	0.6	-1.4	-0.3	0.5	-1.2	-0.0
Suffer from ‘nerves’	0.3	0.4	2.1	-0.2	-0.6	-0.4	0.4	0.0	0.7	-1.2	0.2	-1.4	-0.1	0.6	-0.3
Overall health rating	0.3	0.6	2.0	0.7	-0.2	0.9	0.6	0.9	0.6	1.1	-0.3	-1.4	0.8	0.2	0.6
Knee pain experienced in last month	0.3	0.5	1.4	-0.3	-0.3	-0.5	-0.5	-0.9	-0.4	0.7	-0.9	-1.2	-0.5	-0.4	-0.9
Long-standing illness, disability or infirmity	0.3	0.4	1.1	0.9	-0.1	0.9	-0.2	-0.2	-0.3	1.1	-0.4	-1.0	0.9	-0.6	0.1
Friendships satisfaction	0.3	0.4	1.1	0.5	0.9	0.8	0.0	0.5	-0.1	0.9	0.1	1.1	0.6	-0.0	0.4
Smoking status: Current	0.3	0.5	1.5	1.2	0.3	1.1	-0.3	0.3	0.6	-0.2	0.1	-0.7	1.2	-0.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.7	-1.2	-1.1	-1.3	0.2	-0.1	0.1	-0.7	-0.4	-0.9	-1.2	0.0	-0.4
Financial situation satisfaction	0.3	0.3	0.8	-0.4	-0.5	-0.2	-0.7	-0.3	-0.8	-0.1	-0.9	-0.8	-0.4	-0.8	-0.5
Medication: Paracetamol	0.3	0.5	1.0	0.6	-0.5	0.7	0.6	0.9	1.0	0.4	0.2	-0.4	0.7	0.9	1.0
Medication: Lisinopril	0.3	0.4	2.4	-0.1	-0.5	-0.2	-0.3	-0.1	-0.1	-0.8	-0.8	-1.6	-0.1	-0.3	-0.5
Medication: Atorvastatin	0.3	0.3	1.7	-0.4	-0.2	-0.7	0.3	-0.6	0.5	-0.1	-0.2	-1.3	-0.4	0.4	-0.7
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.3	1.0	0.6	0.6	-1.5	-1.2	-0.5	0.4	-0.6	0.4	1.1	-0.9	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	0.6	0.6	0.8	0.8	0.6	0.4	0.6	0.7	0.2	0.6	0.6	0.6
Neuroticism (Nagel 2018)	0.2	0.5	1.3	0.7	0.1	0.4	0.8	0.5	1.1	-0.1	0.6	-0.6	0.7	1.1	0.6
Worry (Nagel 2018)	0.2	0.5	1.3	0.7	0.3	0.4	0.7	0.2	1.2	-0.2	0.7	-0.2	0.8	1.1	0.7
Rheumatoid Arthritis	0.2	0.2	1.0	0.5	0.5	0.2	-0.3	-0.2	0.4	0.5	-0.2	0.4	0.4	0.6	1.0
Type 2 Diabetes (T2D) (2012)	0.2	0.3	1.6	-0.5	-0.8	-0.4	-0.2	-0.3	0.2	-0.4	-0.5	-1.3	-0.3	-0.1	-0.4
BMI	0.2	1.0	4.7	-0.1	-0.9	0.1	1.3	1.1	1.3	-0.6	0.1	-2.2	0.0	1.1	0.2
Waist Hip Ratio (WHR)	0.2	0.7	2.7	1.0	1.6	1.1	0.5	0.4	0.7	0.5	0.8	0.9	1.0	0.4	0.0
Smoking Status	0.2	0.5	2.8	0.4	-0.6	0.3	-0.6	-0.0	0.3	-0.5	-0.6	-1.7	0.5	-0.6	-1.1
Allergy or Eczema	0.2	0.6	1.3	0.9	0.9	1.2	0.7	1.1	0.3	0.8	0.4	0.1	1.0	0.1	0.6
Cardiovascular Disease	0.2	0.8	2.6	-0.4	-0.1	-0.1	1.6	1.3	1.0	0.0	0.7	-0.5	-0.3	1.0	1.4
Sensitivity / hurt feelings	0.2	0.3	1.5	-0.0	-1.2	-0.2	-0.2	-0.4	-0.2	-0.7	-0.5	-1.1	0.0	-0.3	0.1
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.9	-0.3	-0.7	-0.5	-0.2	-0.4	-0.0	-0.4	-0.4	-0.9	-0.5	-0.2	-0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.7	0.3	-0.1	0.5	-0.3	0.1	-0.1	0.5	-0.6	-0.8	0.3	-0.4	-0.2
Diabetes (mother)	0.2	0.2	0.7	-0.6	-0.8	-0.6	-0.1	-0.5	-0.4	-0.3	-0.3	-0.8	-0.5	0.0	-0.4
Fed-up feelings	0.2	0.3	0.9	-0.4	-0.8	-0.6	-0.4	-0.6	-0.4	-1.0	-0.6	-0.6	-0.5	0.1	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	0.1	-0.0	0.2	0.9	1.0	0.9	0.7	0.8	0.1	0.0	0.8	0.9
High blood pressure	0.2	0.6	2.1	-0.6	-0.1	-0.3	1.5	1.3	0.9	0.1	0.5	-0.4	-0.7	1.0	0.8
Supplements: Glucosamine	0.2	0.3	1.1	0.2	0.3	0.2	-0.7	-0.6	-0.7	0.8	-0.4	-0.3	0.1	-1.1	-0.6
Medication: Levothyroxine sodium	0.2	0.3	1.0	-0.6	-0.0	-0.5	1.0	0.5	0.5	0.1	0.9	-0.0	-0.7	0.8	0.1
Chronic bronchitis/emphysema (father)	0.2	0.3	1.1	-0.6	-0.5	-0.7	-0.3	-1.1	-0.6	0.0	-0.6	-0.1	-0.4	0.3	0.1
Body mass index (BMI)	0.2	0.7	5.7	-0.1	-0.6	0.2	0.4	0.6	0.1	0.2	-0.8	-2.4	-0.1	-0.3	-0.8
Trunk fat mass	0.2	0.8	5.0	-0.7	-0.6	-0.5	0.3	0.1	-0.1	0.2	-0.8	-2.2	-0.7	-0.4	-1.1
Past tobacco smoking	0.2	0.4	1.1	0.7	1.1	0.4	-0.8	-0.8	-0.4	0.5	-0.1	0.9	0.6	-0.3	-0.0
Alcohol usually taken with meals	0.2	0.3	1.1	-0.3	0.3	-0.1	-0.3	-0.4	-1.1	-0.8	0.1	0.5	-0.3	-0.8	-0.9
Allergy	0.2	0.5	2.0	-0.3	-0.2	-0.8	0.3	-0.6	0.7	-1.4	0.7	0.4	-0.4	0.9	-0.3
Weight	0.2	0.8	5.4	-0.8	-0.7	-0.3	0.5	0.7	0.1	-0.1	-0.7	-2.3	-0.8	-0.4	-1.1
Arm fat percentage (right)	0.2	0.8	5.9	-0.7	-0.9	-0.6	0.4	0.1	0.0	0.1	-0.9	-2.4	-0.7	-0.1	-1.0
Time employed in main current job	0.2	0.2	1.1	-0.0	0.5	-0.1	-0.2	-0.5	-0.5	1.0	-0.2	1.1	-0.0	0.0	0.1
Number of live births	0.2	0.3	0.8	0.9	0.6	0.9	-0.4	0.2	-0.0	0.4	-0.1	0.5	0.8	-0.5	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.9	0.5	0.5	0.8	0.2	0.9	0.1	-0.7	0.4	0.8	0.5	0.1	0.1
Medication: Lansoprazole	0.2	0.2	0.5	0.6	0.3	0.4	0.7	0.0	0.7	0.3	0.2	-0.7	0.5	0.6	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.9	-1.4	-1.3	-1.3	0.2	0.2	0.2	-0.8	-0.2	-0.7	-1.4	0.1	-0.3
Arm fat mass (right)	0.2	0.9	6.4	-0.7	-0.8	-0.4	0.3	0.2	-0.1	-0.0	-1.0	-2.5	-0.7	-0.4	-1.2
Trunk predicted mass	0.2	0.9	3.2	-1.3	-0.9	-0.9	0.5	0.6	0.2	-0.9	-0.3	-1.8	-1.3	-0.1	-0.8
Breastfed as a baby	0.2	0.2	1.2	0.1	0.9	0.3	0.2	0.5	0.2	0.3	0.6	1.1	0.0	-0.1	-0.3
Birth weight of first child	0.2	0.4	0.9	0.8	0.7	0.8	-0.6	-0.1	-0.4	0.4	-0.4	0.6	1.0	-0.8	0.3
Peak expiratory flow (PEF)	0.2	0.4	1.4	-0.8	-0.7	-0.7	0.3	0.3	0.1	-1.2	-0.2	-0.7	-0.8	-0.0	-0.4
Loud music exposure frequency	0.2	0.2	0.6	-0.8	-0.7	-0.6	0.1	0.2	-0.3	0.5	-0.1	-0.8	-0.8	-0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.2	-0.4	-1.1	-0.7	-0.7	-0.7	-0.3	-0.0	-0.5	-0.1	-0.3	-0.1	0.6
Medication: Paracetamol	0.2	0.4	0.8	0.8	-0.3	0.8	0.3	0.7	0.8	0.3	0.0	-0.3	0.9	0.7	0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.1	-0.1	-0.5	-0.2	-1.0	-0.9	-0.9	-0.3	-0.4	0.4	-0.1	-0.8	-0.5
Glaucoma (self-reported)	0.2	0.3	0.8	0.3	0.8	0.6	0.3	0.9	0.1	0.7	0.5	0.8	0.3	-0.1	-0.0
Gout (self-reported)	0.2	0.2	0.8	-0.2	-0.6	-0.4	-0.5	-0.9	0.1	-0.3	-0.6	-0.4	-0.1	-0.0	-0.4
Forced vital capacity (FVC), Best measure	0.2	0.8	2.2	-1.5	-1.2	-1.4	0.1	-0.0	0.2	-0.7	-0.0	-0.7	-1.5	-0.1	-0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.7	-0.4	-0.7	-0.3	0.8	0.2	0.2	-0.7	0.7	-0.1	-0.5	0.8	0.3
Family relationship satisfaction	0.2	0.2	0.6	-0.7	-0.2	-0.2	0.2	0.8	-0.3	-0.1	0.1	-0.2	-0.6	-0.5	-0.5
Leg pain on walking	0.2	0.3	1.2	-0.6	-1.1	-0.4	0.2	0.4	-0.5	-0.2	-0.6	-0.8	-0.6	-0.3	-0.2
Hypertension (Self-reported)	0.2	0.5	1.7	-0.2	0.0	-0.0	1.2	1.3	1.0	0.2	0.4	-0.3	-0.3	0.9	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	1.3	0.6	-0.1	0.3	-1.2	-0.4	0.2	0.4	-0.9	-0.4	0.5	-0.8	-0.1
Arm fat percentage (left)	0.2	0.7	4.8	-0.6	-0.8	-0.5	0.4	0.0	-0.1	0.1	-0.8	-2.2	-0.6	-0.2	-0.9
Medication for cholesterol	0.2	0.3	1.5	-0.4	-0.5	-0.4	0.2	0.4	0.2	-1.2	0.5	-1.1	-0.3	-0.2	-0.2
Arm fat mass (left)	0.2	0.8	5.9	-0.6	-0.8	-0.4	0.3	0.2	0.0	0.1	-0.8	-2.4	-0.6	-0.3	-1.0
Number of self-reported non-cancer illnesses	0.2	0.3	1.6	0.3	0.5	0.5	-0.3	0.1	-0.4	1.3	-0.8	-0.2	0.4	-0.4	0.5
Guilty feelings	0.2	0.2	1.2	-0.0	-0.4	-0.1	-0.1	-0.2	-0.6	-1.1	-0.2	-0.9	-0.1	-0.3	-0.4
Medication: Blood pressure	0.2	0.3	1.1	-0.0	-0.1	0.1	-0.6	-0.4	-1.0	0.6	-0.9	1.0	-0.2	-0.4	-0.0
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.9	-0.4	-1.0	-0.5	-0.3	-0.4	-0.4	-0.4	-0.7	-0.5	-0.4	0.1	-0.3
Alcohol drinker status: Never	0.2	0.2	1.3	-0.2	0.1	-0.2	-0.3	-0.4	-0.3	1.1	-0.3	-0.3	-0.2	-0.7	-0.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.0	-0.4	0.2	-0.1	1.0	0.4	0.2	0.2	0.4	-0.5	-0.4	0.5	-0.4
Ever depressed for a whole week	0.2	0.3	0.8	0.3	-0.1	0.4	0.7	0.7	0.5	0.2	0.6	0.2	0.2	0.7	0.9
Alcohol drinker status: Previous	0.2	0.3	0.9	0.5	-0.2	0.1	-0.6	-0.5	-0.5	0.6	-0.6	0.3	0.5	-0.3	1.0
Pack years of smoking	0.2	0.3	0.7	-0.8	-0.4	-0.8	-0.1	-0.2	-0.0	0.1	-0.4	-0.8	-0.8	-0.0	0.1
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	0.5	-0.3	0.3	0.3	0.2	0.7	0.1	-0.0	-0.7	0.5	0.6	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	-0.8	-0.2	-0.6	1.0	0.7	0.3	-0.1	0.9	0.4	-0.7	0.8	0.5
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	-0.0	-0.1	0.0	0.3	0.3	0.5	0.3	0.5	0.5	-0.0	0.3	0.2
Irritable Bowel Disease (IBD)	0.1	0.2	1.1	-0.3	-0.4	-0.3	0.0	0.1	-0.2	0.6	-0.2	-0.0	-0.5	0.4	1.1
Ovarian Cancer	0.1	0.1	0.7	-0.2	0.3	0.0	0.1	0.1	-0.2	0.5	0.2	0.8	-0.3	-0.1	-0.3
Heel T-Score	0.1	0.6	1.9	0.6	0.9	0.4	0.4	0.1	0.8	0.5	0.7	1.4	0.6	1.0	0.7
Height	0.1	1.2	3.8	-1.9	-0.7	-1.6	-0.8	-0.2	-1.0	-0.7	-0.8	0.2	-1.9	-0.9	-0.9
Hand grip strength (left)	0.1	0.2	1.8	-0.5	-0.6	-0.3	0.2	0.2	-0.0	-1.3	-0.2	-0.1	-0.4	0.2	0.3
Pack years adult smoking proportion	0.1	0.2	0.4	-0.5	-0.2	-0.3	0.3	0.4	0.5	0.1	-0.0	-0.7	-0.4	0.3	0.5
Impedance of leg (right)	0.1	0.3	1.8	-0.4	-0.0	-0.6	-0.3	-0.8	-0.4	0.5	0.2	1.3	-0.4	0.4	0.6
Leg fat-free mass (left)	0.1	0.4	2.2	-0.4	-0.2	0.0	0.4	0.9	0.4	0.0	-0.4	-1.5	-0.4	-0.4	-0.8
Trunk fat percentage	0.1	0.5	3.6	-0.6	-0.4	-0.5	0.2	-0.0	-0.2	0.4	-0.7	-1.9	-0.5	-0.4	-1.0
Hand grip strength (right)	0.1	0.2	0.7	-0.2	-0.5	-0.1	-0.1	0.1	-0.2	-0.8	-0.6	0.0	-0.1	-0.1	0.7
Relative age voice broke	0.1	0.2	0.6	0.0	-0.0	-0.0	0.6	0.6	0.7	0.1	0.4	0.1	0.1	0.8	0.8
Age when periods started (menarche)	0.1	0.3	0.8	-0.8	-0.5	-0.9	0.1	-0.9	0.1	0.3	0.2	0.1	-0.7	0.7	0.2
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.6	0.5	0.5	0.7	-0.1	0.5	-0.3	1.3	-0.4	0.1	0.5	-0.3	0.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.5	-0.4	-0.6	-0.2	0.5	0.5	0.1	-0.7	0.3	-0.2	-0.2	0.3	0.0
Impedance of leg (left)	0.1	0.3	1.2	-0.6	-0.2	-0.8	-0.6	-1.1	-0.7	-0.2	0.1	0.9	-0.5	-0.0	0.1
Leg predicted mass (left)	0.1	0.4	2.3	-0.4	-0.3	-0.0	0.3	0.8	0.3	0.0	-0.4	-1.5	-0.4	-0.4	-0.8
Waist circumference	0.1	0.4	1.5	0.0	0.3	0.4	1.0	1.1	0.8	0.4	0.1	-1.2	0.0	0.4	-0.3
Forced vital capacity (FVC)	0.1	0.5	1.6	-0.7	-0.5	-0.7	0.8	0.8	1.3	-0.5	0.9	-0.4	-0.7	0.7	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.6	0.4	0.4	0.3	-0.1	0.0	0.4	0.8	-0.1	-0.4	0.4	-0.1	0.3
Qualifications: None of the above	0.1	0.2	1.1	-0.2	-0.2	-0.2	0.5	0.3	0.8	0.5	0.3	0.3	-0.3	1.0	0.3
Diabetes (self-reported)	0.1	0.2	0.6	0.4	-0.0	0.2	-0.2	-0.6	0.4	0.8	-0.5	-0.2	0.4	0.7	0.7
Medication: Simvastatin	0.1	0.2	0.8	0.1	0.5	0.3	-0.0	-0.1	-0.3	0.2	-0.5	0.9	0.1	0.5	0.7
Neuroticism score	0.1	0.3	0.8	0.3	-0.4	0.2	0.5	0.3	0.7	-0.5	0.2	-0.9	0.4	0.6	0.5
Impedance of arm (right)	0.1	0.4	1.2	-0.8	-0.2	-1.1	-0.5	-1.0	-0.6	0.0	-0.0	0.7	-0.8	-0.0	-0.4
Trunk fat-free mass	0.1	0.8	3.1	-1.3	-0.9	-0.8	0.4	0.6	0.1	-0.9	-0.4	-1.8	-1.3	-0.2	-0.9
Worrier / anxious feelings	0.1	0.2	0.8	0.4	-0.4	0.1	-0.2	-0.6	0.1	-0.4	-0.5	-0.9	0.5	-0.2	-0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.1	-0.5	-0.7	-0.5	0.6	0.7	1.0	-0.6	0.4	-0.5	-0.5	0.4	0.2
Impedance of arm (left)	0.1	0.4	1.6	-0.6	0.3	-0.8	-0.3	-1.0	-0.5	-0.0	0.4	1.3	-0.5	0.1	-0.3
Standing height	0.1	0.8	2.9	-1.7	-0.6	-1.4	0.2	0.1	-0.2	-1.0	0.2	-0.4	-1.7	-0.3	-0.8
Tense / ‘highly strung’	0.1	0.2	0.7	0.1	0.1	0.0	0.5	0.3	0.7	-0.1	0.6	0.4	0.1	0.8	0.5
Body fat percentage	0.1	0.4	3.1	-0.3	-0.3	-0.2	0.4	0.2	0.0	0.6	-0.7	-1.8	-0.3	-0.2	-0.7
Leg fat percentage (right)	0.1	0.3	1.5	0.0	-0.1	0.3	0.6	0.5	0.1	1.1	-0.5	-1.2	0.0	0.1	-0.1
Arm fat-free mass (right)	0.1	0.4	2.0	-0.8	-0.5	-0.4	0.3	0.7	0.2	-0.5	-0.3	-1.4	-0.8	-0.3	-0.6
Whole body fat mass	0.1	0.6	4.6	-0.4	-0.5	-0.2	0.4	0.4	0.1	0.3	-0.8	-2.1	-0.4	-0.2	-0.7
Leg fat mass (right)	0.1	0.4	2.6	-0.0	-0.2	0.3	0.5	0.7	0.1	0.9	-0.7	-1.6	-0.0	-0.2	-0.4
Arm predicted mass (right)	0.1	0.4	2.0	-0.6	-0.5	-0.2	0.0	0.4	-0.0	-0.5	-0.5	-1.4	-0.6	-0.6	-0.7
Comparative height size at age 10	0.1	0.3	0.9	-0.7	0.3	-0.5	0.5	0.3	-0.0	-1.0	0.6	-0.3	-0.9	-0.2	-0.6
Illnesses of father: Heart disease	0.1	0.1	0.7	-0.2	-0.5	-0.3	0.2	0.2	0.0	-0.6	-0.4	-0.8	-0.2	0.0	0.3
Illnesses of siblings: Diabetes	0.1	0.1	0.4	-0.3	0.7	0.0	0.3	0.1	-0.4	0.4	0.3	0.4	-0.2	0.1	0.2
Whole body fat-free mass	0.1	0.6	3.1	-0.9	-0.7	-0.5	0.4	0.7	0.3	-0.6	-0.4	-1.8	-0.9	-0.3	-0.9
Leg fat-free mass (right)	0.1	0.4	2.5	-0.4	-0.2	0.0	0.1	0.7	0.2	-0.2	-0.5	-1.6	-0.4	-0.7	-1.0
Average weekly red wine intake	0.1	0.1	0.6	-0.4	-0.3	0.0	0.2	0.8	0.0	-0.1	-0.1	-0.1	-0.3	-0.3	-0.3
Diabetes diagnosed by doctor	0.1	0.2	0.6	-0.1	-0.5	-0.2	-0.4	-0.6	-0.1	0.5	-0.8	-0.4	-0.0	0.3	0.3
Qualifications: nursing, teaching	0.1	0.2	0.7	-0.4	-0.5	-0.3	0.0	-0.2	-0.8	-0.5	0.4	0.1	-0.3	-0.4	-0.3
Breast cancer (self-reported)	0.1	0.1	0.5	-0.0	0.4	0.1	-0.3	-0.2	-0.3	0.6	0.1	0.7	-0.0	-0.0	-0.1
Whole body water mass	0.1	0.6	2.9	-0.9	-0.6	-0.5	0.4	0.8	0.3	-0.6	-0.3	-1.7	-0.9	-0.2	-0.8
Leg predicted mass (right)	0.1	0.5	2.8	-0.4	-0.3	-0.0	0.1	0.7	0.2	-0.3	-0.5	-1.7	-0.4	-0.7	-1.1
Basal metabolic rate	0.1	0.6	3.7	-0.8	-0.7	-0.4	0.4	0.7	0.2	-0.4	-0.5	-1.9	-0.8	-0.4	-0.9
Leg fat percentage (left)	0.1	0.4	2.7	0.1	-0.2	0.3	0.4	0.4	0.1	0.8	-0.6	-1.6	0.1	-0.2	-0.3
Arm fat-free mass (left)	0.1	0.5	2.9	-0.8	-0.6	-0.4	0.5	0.8	0.3	-0.4	-0.3	-1.7	-0.9	-0.1	-0.6
Risk taking	0.1	0.2	0.7	-0.4	-0.3	-0.4	-0.1	-0.2	-0.1	0.7	-0.2	-0.8	-0.4	-0.2	-0.2
Impedance of whole body	0.1	0.4	2.2	-0.2	0.5	-0.5	-0.6	-1.0	-0.7	0.3	0.2	1.5	-0.2	-0.2	-0.0
Leg fat mass (left)	0.1	0.5	3.8	0.0	-0.2	0.3	0.3	0.6	0.1	0.7	-0.8	-1.9	0.0	-0.4	-0.5
Arm predicted mass (left)	0.1	0.6	3.7	-0.8	-0.7	-0.4	0.4	0.7	0.2	-0.5	-0.4	-1.9	-0.9	-0.3	-0.8
Lung FEV1/FVC ratio	0.0	0.2	0.9	0.1	-0.3	0.2	0.6	0.4	0.7	-0.6	-0.2	-0.9	0.0	0.3	-0.3
Lung FVC	0.0	0.1	0.7	-0.2	-0.0	-0.1	0.1	0.2	0.4	-0.5	0.0	-0.3	-0.1	-0.1	-0.8
Hair Pigment	0.0	1.1	5.3	-1.4	-0.9	-1.3	0.2	-0.5	-0.8	-2.3	-0.0	0.2	-1.4	0.2	-0.5
Sitting height	0.0	0.3	1.0	-0.6	0.1	-0.1	-0.1	0.3	-0.4	-0.3	0.0	-0.3	-0.6	-1.0	-0.9
Nervous feelings	0.0	0.0	0.1	0.3	-0.0	0.2	-0.4	-0.4	-0.1	-0.1	0.1	0.1	0.3	-0.0	-0.1

Hub : Genes

CD33

Models

Trait associations