TWAS hub - FPR3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.6250	0.0660	5.8e-10	0.584	NA	0.516	NA	0.576	2.5e-31	NA	2.8e-26	NA	9.7e-31
2	GTEx	Whole Blood	0.1290	0.0530	2.6e-03	0.014	NA	0.000	NA	0.008	1.8e-02	NA	3.4e-01	NA	5.4e-02
3	YFS	Blood	0.1472	0.0225	0.0e+00	0.048	0.078	0.100	0.105	0.102	2.3e-15	3.9e-24	8.5e-31	2.2e-32	1.1e-31
4	TCGA	Lung Adenocarcinoma	0.0505	0.0262	3.3e-03	0.013	0.008	0.013	NA	0.018	9.1e-03	3.2e-02	9.9e-03	NA	2.7e-03
5	TCGA	Lung Squamous Cell Carcinoma	0.0519	0.0247	3.6e-03	0.031	0.023	0.013	NA	0.023	1.7e-04	1.0e-03	1.2e-02	NA	1.1e-03
6	TCGA	Pancreatic Adenocarcinoma	0.1750	0.0730	1.6e-03	0.096	0.032	0.019	NA	0.066	8.2e-05	1.7e-02	5.3e-02	NA	9.7e-04
7	TCGA	Stomach Adenocarcinoma	0.0690	0.0350	8.3e-03	-0.003	0.003	-0.003	NA	-0.003	7.5e-01	1.9e-01	6.0e-01	NA	6.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
HDL Cholesterol	8.8	14.6	27.6	3.4	-1.6	-1.6	-3.4	-4.8	-5.2	-4.8
Asthma (self-reported)	6.4	12.8	26.2	0.5	-0.2	-4.3	-4.0	-4.7	-2.6	-5.1
Asthma	5.9	11.6	24.3	0.6	-0.1	-4.0	-3.9	-4.5	-2.2	-4.9
Allergy	4.6	10.7	22.4	-0.2	1.7	3.4	4.2	4.1	1.9	4.7
Blood Eosinophil Count	4.4	34.2	59.9	-0.3	-0.2	-6.2	-7.7	-7.4	-5.3	-7.7
Mouth/teeth dental problems: Mouth ulcers	4.1	6.5	15.9	2.3	1.2	-2.4	-1.7	-4.0	-1.2	-3.6
Happiness	4.0	4.9	8.8	1.2	1.0	-1.4	-2.6	-2.7	-2.8	-3.0
Medication: Ventolin 100micrograms inhaler	3.9	5.0	10.0	1.0	-0.3	-3.0	-1.9	-3.2	-1.3	-3.1
Friendships satisfaction	3.5	4.3	7.3	1.6	0.2	-1.3	-2.2	-2.7	-2.7	-2.6
Respiratory disease	3.2	7.0	13.4	-0.7	-0.4	-3.3	-3.3	-3.1	-2.0	-3.7
Pain all over the body in last month	3.2	3.4	6.6	0.2	0.8	-1.9	-2.3	-1.8	-2.1	-2.6
Lung FEV1/FVC ratio	3.0	15.0	61.3	-7.8	-0.0	4.0	-1.6	3.0	3.9	1.4
Illnesses of mother	3.0	3.7	9.6	-1.1	-1.5	-1.2	-2.2	-1.5	-3.1	-2.2
Number of full brothers	3.0	3.8	9.0	-0.2	-1.5	-1.3	-1.5	-1.9	-3.0	-2.8
Medication: Seretide 50 evohaler	2.8	3.2	6.8	0.6	-2.6	-1.2	-1.4	-1.5	-2.3	-2.1
Pain experienced in last month	2.7	4.6	8.9	-1.6	-1.0	1.9	1.8	2.7	3.0	2.3
Primary Biliary Cirrhosis	2.6	3.6	5.6	1.4	-1.7	-2.4	-1.4	-1.8	-2.1	-2.3
Wheeze or whistling in the chest in last year	2.4	4.3	9.0	1.7	-1.1	-1.7	-2.2	-2.6	-1.4	-3.0
Family relationship satisfaction	2.4	3.0	7.8	0.1	1.4	-1.0	-2.3	-1.4	-2.8	-1.7
Hayfever, allergic rhinitis or eczema	2.3	4.9	9.9	-0.7	-0.8	-1.9	-3.1	-2.8	-1.5	-3.1
Tense / ‘highly strung’	2.3	3.8	11.6	-0.9	1.2	0.1	2.1	1.8	3.4	2.3
Allergy or Eczema	2.2	5.8	13.1	-1.1	-0.2	-1.2	-3.6	-3.3	-1.3	-3.5
Age started oral contraceptive pill	2.2	2.8	7.7	-2.3	-1.9	0.2	-2.8	-0.4	-1.3	-0.9
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	7.5	-0.8	-0.4	0.4	1.6	2.4	1.3	2.7
Heel T-Score	1.9	14.9	26.8	-2.7	-1.1	4.3	2.9	4.5	4.8	5.2
Prospective memory result	1.9	2.4	6.3	-1.3	-0.3	-0.7	1.5	2.0	2.5	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.0	15.3	-0.8	3.9	0.4	1.9	2.4	2.1	3.5
Suffer from ‘nerves’	1.9	3.0	7.1	-2.7	0.3	0.4	1.3	1.4	2.2	2.3
Osteoarthritis (self-reported)	1.9	2.4	5.6	2.0	-0.4	-2.4	-0.7	-1.7	-0.6	-1.8
Medication: Ibuprofen	1.8	2.2	6.1	-1.3	-0.5	0.3	0.9	2.5	0.5	2.5
Multivitamins +/- minerals	1.7	2.1	4.6	-1.0	-0.2	0.5	1.5	2.1	2.0	1.7
Had major operations	1.7	2.0	4.7	0.3	-0.5	-0.7	-1.9	-1.8	-1.2	-2.2
Age at last live birth	1.7	2.5	5.4	-1.2	0.7	0.9	1.9	1.9	1.4	2.3
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	4.5	-0.9	-0.6	-0.3	1.5	2.1	1.6	1.9
Medication: Metformin	1.6	2.3	7.9	2.8	-0.2	-1.4	-0.2	-1.8	-0.9	-1.5
Breastfed as a baby	1.6	2.0	3.4	0.2	-1.8	-0.7	-1.5	-1.8	-1.4	-1.6
Number of full sisters	1.6	2.0	4.1	0.8	1.4	-1.7	-1.4	-1.6	-0.2	-2.0
Supplements: Calcium	1.6	1.8	4.7	-0.7	0.8	1.7	0.3	2.2	1.7	0.9
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	4.9	0.9	-0.0	-0.4	-2.2	-2.0	-0.8	-1.9
Financial situation satisfaction	1.5	1.8	4.0	1.0	0.6	-1.8	-0.1	-1.4	-2.0	-1.5
Medication: Lisinopril	1.5	1.9	6.9	0.5	-2.6	1.4	-0.5	1.6	0.2	1.2
Sensitivity / hurt feelings	1.4	2.4	5.7	0.2	0.7	-2.0	-1.3	-2.4	-0.1	-2.1
Medication: Omeprazole	1.4	1.7	3.9	-0.8	-1.3	0.8	0.9	2.0	0.8	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	7.0	-1.5	2.6	0.1	0.5	1.7	1.6	2.4
Average weekly spirits intake	1.3	1.6	5.0	2.2	0.7	-2.1	-0.5	-0.7	-0.4	-0.9
Chronic bronchitis/emphysema (father)	1.3	1.5	6.8	0.4	-2.6	-1.0	0.8	-0.8	-1.1	-0.4
Chronic bronchitis/emphysema (mother)	1.3	1.5	5.2	-0.7	0.3	2.3	-1.2	-0.3	1.6	-0.8
Forced vital capacity (FVC), Best measure	1.3	4.9	17.0	1.1	4.1	-0.8	1.9	1.4	0.9	2.9
Number of operations (self-reported)	1.3	2.0	4.1	1.2	-1.0	-0.1	-1.9	-2.0	0.2	-2.0
Ovarian Cancer	1.2	1.6	3.4	1.4	-0.3	-1.8	-0.2	-1.4	-1.3	-1.4
Fasting Glucose	1.2	1.4	3.4	-1.1	-1.4	0.9	-1.9	-0.6	-0.7	-1.3
Vitamin and mineral supplements	1.2	1.6	3.0	1.4	1.1	-0.0	-1.0	-1.5	-1.7	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	7.0	-1.1	0.2	1.1	2.0	1.2	1.8	2.6
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	4.1	1.0	2.0	0.0	0.7	0.7	1.5	1.1
Lung cancer (father)	1.2	1.4	4.7	1.7	-0.6	-2.2	0.5	-0.9	-0.5	-0.5
Loud music exposure frequency	1.2	1.3	4.3	2.1	0.0	-1.1	1.8	0.4	-0.3	0.4
Eye problems/disorders: None of the above	1.2	1.4	2.3	-0.6	-1.1	1.2	1.2	1.3	1.5	1.2
Loneliness, isolation	1.2	1.7	6.7	1.7	-0.7	-2.6	-0.1	-0.5	-1.0	-0.7
Commuting to job workplace: Walk	1.2	1.3	2.6	-0.6	-0.2	-0.1	-1.4	-1.6	-1.6	-1.3
Alzheimer’s Disease (in mother)	1.1	1.3	2.1	0.8	-1.1	1.4	0.6	1.2	1.2	1.4
Ulcerative Colitis (UC)	1.1	2.0	4.8	-0.5	0.8	-1.8	-1.6	-1.1	-1.2	-2.2
Prostate Cancer	1.1	1.6	4.0	2.0	-1.3	-0.8	-0.3	-1.9	-0.2	-1.2
Body Mass Index (BMI) (2010)	1.1	1.5	2.7	-1.5	-1.6	0.5	1.3	1.0	1.5	0.6
LDL Cholesterol	1.1	1.7	6.6	0.6	0.4	0.7	-1.0	-1.2	-2.6	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	4.9	-1.4	1.3	0.3	1.7	0.9	2.2	2.2
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	8.2	-0.7	2.4	1.0	1.4	1.9	2.0	2.9
Birth weight of first child	1.1	2.0	5.4	-2.3	-0.2	0.8	-1.8	-1.1	-1.6	-1.0
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.6	0.9	0.1	1.6	0.3	1.9	1.4	1.8
Birth weight	1.1	2.4	12.9	-3.6	-0.8	1.0	-0.9	0.9	0.5	0.2
Number of children fathered	1.1	1.2	3.3	-0.1	-1.4	-0.6	-1.8	-0.6	-0.7	-1.5
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.2	1.2	-0.0	-1.7	-1.8	-0.3	-0.1	-1.3
Illnesses of father: None of the above (group 1)	1.1	1.3	8.1	0.7	0.1	-2.8	0.6	0.5	-0.2	0.4
Average weekly champagne plus white wine intake	1.1	1.5	2.9	0.2	-1.7	1.4	-1.4	-0.3	-1.6	-1.1
Fractured/broken bones in last 5 years	1.1	1.4	5.2	1.7	0.6	-0.4	2.3	-0.1	0.8	1.0
Alzheimer’s Disease (including proxy)	1.0	1.5	5.1	0.2	-2.0	2.2	0.5	0.7	0.6	0.7
Age at First Birth	1.0	1.4	3.0	1.1	-1.7	0.3	1.5	0.9	-0.5	1.4
Current tobacco smoking	1.0	1.6	4.8	2.0	0.1	-0.4	0.2	-1.2	-2.2	-1.1
Age when periods started (menarche)	1.0	2.3	5.6	0.4	1.0	0.8	-1.9	-1.9	-1.3	-2.4
Medication: Levothyroxine sodium	1.0	1.7	3.5	0.1	0.9	0.7	1.9	1.7	1.2	1.7
Diabetes (self-reported)	1.0	1.5	3.3	1.8	0.8	-1.7	-0.6	-1.5	-0.3	-1.0
Medication: Simvastatin	1.0	1.4	3.2	-1.4	-0.5	1.6	-0.7	1.8	0.9	0.8
Falls in the last year	1.0	1.3	2.9	0.3	-1.1	0.0	-1.2	-1.4	-1.3	-1.7
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.3	1.2	1.4	-0.9	0.8	1.5	0.5	0.9
Diabetes diagnosed by doctor	1.0	1.7	4.0	2.0	0.4	-1.4	-0.7	-1.7	-0.2	-1.5
Osteoporosis (self-reported)	1.0	1.2	3.4	-0.7	-1.9	0.3	1.0	1.2	1.0	1.0
Smoking status: Current	1.0	1.5	4.3	1.8	0.6	-0.2	-0.2	-1.2	-2.1	-1.2
Hearing aid user	1.0	1.1	2.8	-1.4	-1.7	1.2	-0.8	-0.1	0.8	-0.5
Alcohol drinker status: Never	1.0	1.2	3.7	1.4	-1.9	-0.3	0.9	-0.0	-0.8	1.0
Worry (Nagel 2018)	0.9	1.9	3.9	-1.3	-0.3	-1.1	0.8	1.6	1.8	2.0
Lung FVC	0.9	4.8	13.7	-0.4	2.6	0.5	2.3	1.7	2.1	3.7
Diabetes (father)	0.9	1.1	3.8	1.5	0.1	-0.6	0.5	-0.5	2.0	-0.6
Taking other prescription medications	0.9	1.4	4.8	1.5	0.1	-2.2	-0.2	-1.1	0.6	-1.0
Past tobacco smoking	0.9	1.7	5.2	-0.8	-2.3	2.2	0.4	0.4	0.8	0.7
Fluid intelligence score	0.9	1.9	4.4	1.7	2.1	0.5	-1.4	-1.0	-1.5	-0.8
Pulse wave Arterial Stiffness index	0.9	1.0	2.3	1.4	0.4	-1.5	-0.9	-0.3	-0.9	-1.0
Blood clot in the leg (DVT)	0.9	1.1	2.4	1.5	-1.5	-0.4	-0.4	-1.2	-0.4	-1.2
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	4.2	0.2	1.1	0.3	2.0	1.8	1.4	1.3
Exposure to tobacco smoke outside home	0.9	1.2	2.3	-0.4	0.3	-0.9	-1.5	-1.4	-1.4	-1.2
Pulse wave peak to peak time	0.9	1.0	2.5	-1.3	-0.3	1.6	1.0	0.3	0.8	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	5.4	-1.0	0.1	0.6	-0.5	0.4	2.3	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.5	-0.5	0.3	-1.0	0.8	1.6	1.4	1.2
Illnesses of father: Heart disease	0.9	1.2	3.1	-1.7	0.3	1.3	-1.8	0.2	0.7	-0.1
Smoking status: Previous	0.9	1.3	4.9	0.1	2.2	-1.8	0.2	0.4	0.6	0.3
Back pain experienced in last month	0.9	1.3	6.5	1.4	0.3	-2.5	0.9	0.1	-0.3	0.3
Average weekly beer plus cider intake	0.9	1.3	7.1	-2.7	0.4	0.9	0.0	0.7	0.2	0.6
Risk taking	0.9	1.4	3.7	0.9	-0.8	-0.2	-1.6	-0.5	-1.9	-1.3
Breast Cancer	0.8	1.9	4.8	1.3	-0.1	0.5	2.2	1.5	1.2	1.7
Mean Putamen Volume	0.8	0.9	2.8	0.9	1.0	-0.5	1.7	-0.2	0.9	0.7
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.1	1.8	1.3	-1.5	-0.1	-1.5	-0.3	-1.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.0	0.1	1.4	-1.3	-1.1	-0.7	-0.7	-0.6
Severe depression (siblings)	0.8	0.9	2.5	-1.2	-0.3	-0.1	0.1	1.6	1.3	0.8
Townsend deprivation index at recruitment	0.8	1.2	2.8	0.9	1.7	-1.6	-0.1	-0.8	-0.7	-1.0
Number of incorrect matches in round	0.8	1.4	4.7	-2.2	1.5	-1.1	0.0	1.0	0.4	0.7
Illnesses of siblings	0.8	1.1	3.2	1.8	-1.2	-0.5	1.3	0.1	-1.1	0.3
Peak expiratory flow (PEF)	0.8	1.8	3.7	-0.3	1.9	-0.9	0.9	1.2	1.4	1.9
Pulse wave reflection index	0.8	0.9	2.4	0.8	1.2	-1.6	-0.2	-0.4	-1.3	-0.4
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.1	-0.8	1.0	1.8	0.1	0.5	1.5	0.4
Supplements: Vitamin C	0.8	0.9	4.3	0.6	0.3	-2.1	1.1	0.1	-0.5	0.6
Mineral and other dietary supplements	0.8	1.1	3.0	1.7	1.0	-1.0	0.8	-0.7	-1.2	-0.2
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.9	-0.9	-0.6	1.7	0.7	0.5	0.8	1.2
Basal cell carcinoma (self-reported)	0.8	0.9	3.6	-0.9	-0.7	1.9	-0.1	0.6	0.9	0.5
Major Depression (MDD)	0.7	0.9	2.5	1.6	-0.6	1.1	0.3	0.7	0.1	1.1
Ulcerative Colitis	0.7	1.0	1.9	-1.4	1.0	-0.7	-0.9	-0.9	-0.3	-1.2
Smoking Status	0.7	1.8	8.9	0.8	3.0	-1.3	0.9	0.3	-0.5	0.2
Hypothyroidism (self reported)	0.7	1.6	3.3	-0.4	1.6	0.0	1.8	1.4	1.5	1.1
Relative age of first facial hair	0.7	1.5	4.7	0.3	-0.8	-0.5	-1.1	-2.2	-0.7	-1.7
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.9	-0.8	0.3	0.0	0.8	1.7	1.4	0.6
Nervous feelings	0.7	1.3	3.5	-0.6	-0.5	-1.0	1.2	0.8	1.9	1.2
Had menopause	0.7	0.8	1.7	0.3	0.2	-0.7	-1.1	-1.1	-1.3	-0.9
Noisy workplace	0.7	0.9	1.6	1.3	0.6	-1.0	-0.9	-1.0	-0.7	-1.0
Exposure to tobacco smoke at home	0.7	0.8	1.8	1.4	0.4	-0.5	1.3	0.6	0.8	0.8
High blood pressure (siblings)	0.7	0.9	3.0	-1.7	0.4	0.4	-1.0	0.5	1.5	0.1
Age at first live birth	0.7	1.2	4.2	-0.6	2.1	0.8	0.9	0.5	0.6	1.4
Health satisfaction	0.7	0.9	3.5	0.0	0.8	0.2	-1.0	-0.6	-1.9	-0.7
Medication: Allopurinol	0.7	0.9	1.9	-0.4	-1.0	-0.7	-1.3	-0.6	-1.4	-1.0
Ever smoked	0.7	1.2	3.5	0.6	1.2	-1.5	-0.4	-0.7	-1.9	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.3	1.5	-0.9	-0.4	-0.5	-1.1	-0.3	-1.1
Heart disease (siblings)	0.7	0.8	1.8	-1.3	1.3	0.5	-1.2	-0.3	0.9	-0.0
Alcohol drinker status: Previous	0.7	0.8	3.2	0.3	1.8	-1.5	-0.4	-0.4	0.2	-0.1
Schizophrenia (2018)	0.6	1.2	2.2	0.4	0.6	-1.4	1.3	0.5	1.5	1.2
Neuroticism (2016)	0.6	0.9	2.5	0.7	-1.4	-1.6	-0.5	-0.3	0.1	-0.9
Rheumatoid Arthritis	0.6	0.9	4.0	-0.3	2.0	-1.1	0.1	-0.8	0.3	-0.3
Angina	0.6	0.7	1.8	-0.3	-1.2	-0.3	1.4	0.9	-0.1	1.0
Supplements: Zinc	0.6	0.7	2.7	-1.7	-0.2	-1.1	-0.3	0.8	0.0	0.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.0	0.4	-1.2	0.5	1.4	-0.2	0.6	0.8
High blood pressure (mother)	0.6	0.9	3.3	0.7	0.7	-0.3	0.8	0.2	1.8	1.0
Waist circumference	0.6	2.3	5.4	2.1	-0.2	-2.3	-1.1	-1.8	-1.0	-1.2
Mouth/teeth dental problems	0.6	0.9	1.7	-1.1	-0.8	0.6	0.6	0.9	-1.3	1.1
Heart attack	0.6	0.8	1.6	0.4	0.5	-1.1	-1.0	-1.0	0.2	-1.3
Depression (self-reported)	0.6	0.7	1.5	0.7	1.2	1.0	0.7	0.4	0.4	0.9
Medication: Lansoprazole	0.6	0.7	2.5	-0.3	0.0	-0.6	-0.5	-1.2	-0.1	-1.6
Length of working week for main job	0.6	0.7	1.3	0.6	-0.3	-0.2	-1.0	-1.1	-0.9	-1.1
Leg fat percentage (right)	0.6	2.0	3.3	1.4	-0.0	-0.9	-1.8	-1.8	-1.6	-1.5
Neck or shoulder pain in last month	0.6	0.9	3.6	1.9	0.2	-0.6	0.3	-0.9	-1.2	-0.4
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	3.3	-0.8	-1.8	0.7	-0.4	-0.5	0.4	-0.5
Knee pain experienced in last month	0.6	1.0	2.7	-0.6	-1.0	-0.9	-1.6	-0.9	-0.9	-0.9
Illnesses of siblings: Diabetes	0.6	0.8	1.5	-1.2	0.3	0.7	-0.1	1.1	1.1	1.1
Ever had bowel cancer screening	0.6	0.7	2.5	0.4	0.0	1.1	0.6	0.5	1.6	0.1
Number of self-reported non-cancer illnesses	0.6	1.1	2.9	-0.2	0.7	-1.4	-1.7	-0.6	0.5	-1.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.0	-1.4	0.7	1.1	-1.3	0.1	0.1	-0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.5	0.2	0.8	-0.9	-1.1	-1.0	0.3	-1.2
Intelligence (Savage-Jansen 2018)	0.5	1.7	4.3	-0.1	0.8	1.6	-2.1	-0.7	-1.8	-0.8
Irritable Bowel Disease (IBD)	0.5	1.2	3.6	0.4	0.5	-1.0	-0.9	-1.4	-0.9	-1.9
Bipolar Disorder (2011)	0.5	0.4	1.6	-0.3	0.0	1.2	-0.6	-0.5	-0.6	-0.6
Crohns Disease (2012)	0.5	0.8	1.6	1.1	-0.9	-0.3	1.3	-1.2	0.3	-0.3
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.6	-0.8	1.2	-0.2	-0.2	0.2	1.3	0.7
Medication for hormone replacement therapy	0.5	0.6	2.4	0.5	-1.6	0.1	-0.2	-0.5	-0.3	-1.0
Diabetes (mother)	0.5	0.6	1.4	-0.0	0.2	-1.0	0.6	-1.2	-1.1	-0.6
Qualifications: CSEs or equivalent	0.5	0.7	1.7	1.3	1.3	-0.5	0.4	-0.6	-0.6	-0.3
Sitting height	0.5	3.9	10.2	0.1	1.6	0.5	2.3	2.9	0.9	3.2
Body mass index (BMI)	0.5	2.2	5.0	2.2	-0.2	-2.2	-1.0	-1.5	-1.2	-0.9
Alcohol usually taken with meals	0.5	0.8	2.1	-1.2	0.3	-0.0	-1.4	-0.8	-0.9	-0.9
Had other major operations	0.5	0.6	1.6	-0.1	-0.4	0.7	0.0	0.8	1.2	1.3
Forced vital capacity (FVC)	0.5	2.1	6.2	1.1	2.5	0.1	1.3	0.6	0.7	2.1
Financial difficulties in last 2 years	0.5	0.7	2.5	1.6	-0.0	-1.1	-0.4	-0.7	-0.5	-0.6
Time employed in main current job	0.5	0.6	1.4	-0.1	-0.2	0.7	1.2	1.0	0.5	0.9
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.7	-0.8	1.9	1.4	-0.8	0.5	0.5	0.4
Medication: Cholesterol lowering	0.5	0.7	2.7	-0.2	-0.5	0.3	-0.0	1.1	1.6	0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.4	0.6	-0.1	0.1	1.1	-1.2	-1.6	-0.9
Medication: Amlodipine	0.5	0.7	2.9	0.1	1.1	-0.5	0.4	-0.1	1.7	0.2
Shortness of breath walking on level ground	0.5	0.6	1.6	-0.6	-1.3	0.2	0.5	0.1	1.2	-0.1
Emphysema/chronic bronchitis	0.5	0.6	1.1	1.0	-0.8	-0.6	-0.7	-0.4	-0.8	-0.9
Angina (self-reported)	0.5	0.7	1.4	-0.3	-0.8	-0.3	1.2	1.2	0.2	1.1
Heart disease (mother)	0.5	0.6	1.4	1.2	-0.3	0.5	1.1	0.7	0.3	0.9
Chest pain or discomfort	0.5	0.7	1.9	-0.5	-0.8	-0.2	-1.1	-0.2	-1.4	-0.7
Hypertension (Self-reported)	0.5	1.3	3.9	0.1	0.4	-1.8	-2.0	-0.5	-0.2	-1.2
Breast cancer (self-reported)	0.5	0.5	1.8	-0.5	-1.3	1.2	0.3	-0.2	0.3	0.0
Medication: Aspirin	0.5	0.7	1.7	0.2	1.3	-1.0	-1.3	-0.1	0.1	-0.6
Medication: Gliclazide	0.5	0.6	1.2	0.7	0.3	-1.0	-0.1	-1.1	-0.8	-0.9
Wears glasses or contact lenses	0.5	0.6	1.7	0.7	-0.3	-1.1	0.0	-1.3	-0.8	-0.3
Ever taken oral contraceptive pill	0.5	0.6	1.4	-1.0	-0.6	0.8	-1.2	0.4	-0.1	-0.8
Illnesses of father: High blood pressure	0.5	0.6	2.4	0.1	-0.0	1.6	0.7	0.5	0.6	1.0
Leg fat percentage (left)	0.5	1.7	2.9	1.5	-0.4	-0.8	-1.7	-1.6	-1.5	-1.2
Irritability	0.5	0.9	3.3	0.6	-0.2	-1.0	0.8	0.6	1.8	0.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.4	0.1	-0.7	1.2	-1.0	0.6	0.8	0.4
Myopia	0.5	0.7	1.6	-0.4	-0.2	-0.0	1.3	0.8	1.2	1.0
Pack years of smoking	0.5	0.7	3.1	-0.4	-1.8	-0.2	-0.8	-0.5	-0.3	-0.6
Bipolar Disorder (2018)	0.4	0.7	2.4	0.2	-0.8	-1.5	-0.0	-0.8	-1.1	-0.4
Bipolar Disorder or Schizophrenia	0.4	0.9	4.2	0.5	-0.0	-2.1	1.0	-0.1	0.5	0.7
Depressed Affect (Nagel 2018)	0.4	0.9	1.8	1.0	-0.8	-1.4	0.7	1.1	0.3	1.2
Schizophrenia vs Biploar Disorder	0.4	0.6	1.4	0.7	-0.1	0.4	1.2	0.6	1.2	0.4
Reaction Time	0.4	0.8	1.5	-1.0	-1.2	0.7	0.0	1.0	1.1	0.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.6	1.1	1.9	0.7	-0.9	-0.4	-0.9	0.0
HbA1C	0.4	0.4	1.2	-0.1	-1.1	0.9	0.9	-0.1	-0.2	-0.1
Triglycerides	0.4	0.7	2.3	-1.5	0.3	0.6	0.2	1.0	0.7	0.9
Blood White Count	0.4	2.8	16.0	-0.4	1.4	-4.0	0.3	-0.7	-0.7	-0.4
Hand grip strength (left)	0.4	1.0	2.7	0.6	1.6	-1.3	0.9	0.7	-0.6	0.8
Hearing difficulty/problems: Yes	0.4	0.6	1.8	0.5	1.4	-0.4	1.1	-0.6	-0.0	-0.1
Medication: Co-codamol	0.4	0.4	1.9	-1.4	0.3	-0.5	-0.4	-0.2	0.7	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.1	-0.8	-0.5	-0.7	-1.0	0.0	-0.2	-1.1
Relative age voice broke	0.4	0.7	1.8	1.0	-0.5	-1.3	0.0	-0.6	1.0	-0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	-0.6	-0.3	-0.7	0.8	0.6	0.3	0.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.7	-0.1	0.5	-1.3	0.5	-0.7	-0.1	-0.3
Qualifications: None of the above	0.4	0.8	2.2	-1.2	0.0	-1.1	0.3	-1.5	0.0	-0.9
Weight	0.4	2.0	6.5	2.5	0.5	-1.9	-0.1	-1.1	-1.4	-0.4
Hip circumference	0.4	1.7	7.8	2.8	0.5	-1.3	-0.7	-0.5	-1.1	-0.1
Worrier / anxious feelings	0.4	0.7	1.8	-0.2	-1.2	-1.4	-0.4	0.4	1.0	0.5
Arm fat mass (right)	0.4	1.5	4.4	2.1	-0.3	-1.5	-0.8	-1.4	-0.8	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.1	1.0	1.1	-1.0	0.5	0.4	0.0	0.9
Gout (self-reported)	0.4	0.6	1.8	0.2	-0.8	-0.8	-1.3	-0.0	-0.7	-0.7
Arm fat-free mass (right)	0.4	1.8	5.2	2.3	0.9	-2.0	0.3	-0.1	-1.6	0.3
Worry too long after embarrassment	0.4	0.7	2.9	1.1	0.3	-1.7	0.6	-0.3	0.3	-0.3
Medication for pain relief, constipation, heartburn	0.4	0.7	2.3	0.4	0.5	0.2	-0.4	-1.0	-1.5	-0.9
Migraine (self-reported)	0.4	0.5	1.5	0.0	0.2	-1.2	-0.9	0.3	0.9	-0.0
Mean time to correctly identify matches	0.4	0.7	1.4	-0.9	-1.2	-0.1	-1.0	-0.6	0.2	-1.1
Whole body fat mass	0.4	1.6	3.2	1.8	-0.4	-1.0	-1.2	-1.5	-1.2	-1.3
Leg fat mass (right)	0.4	1.7	3.2	1.8	0.4	-1.1	-1.3	-1.5	-1.5	-1.0
Arm predicted mass (right)	0.4	1.9	5.2	2.3	0.7	-2.1	0.2	-0.4	-1.8	0.1
Pulse rate, automated reading	0.4	1.1	7.2	-2.7	0.2	0.2	-0.1	0.0	0.8	0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.7	1.1	-0.1	0.2	0.3	1.3	0.5	0.3
Medication: Aspirin	0.4	0.5	1.4	-0.3	0.8	-0.6	-1.2	0.3	1.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	2.4	0.5	1.5	-0.3	1.0	0.6	-0.5	0.9
Average weekly red wine intake	0.4	0.6	1.2	-0.6	1.1	0.6	-1.1	-0.5	-0.2	-0.6
Long-standing illness, disability or infirmity	0.4	0.6	2.1	1.2	0.5	-1.5	-0.1	-0.1	0.5	-0.1
Eye problems/disorders: Cataract	0.4	0.4	1.4	0.7	1.0	-0.0	-0.1	-0.2	-1.2	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.1	-0.0	1.5	-0.6	-0.5	-0.5	-0.2	-0.8
Mother’s age at death	0.4	0.5	2.2	-0.5	1.5	-0.7	-0.2	0.3	-0.2	-0.4
Commuting to job workplace: Public transport	0.4	0.5	1.5	0.2	-0.6	0.1	1.2	0.2	-0.5	1.2
Medication: Bendroflumethiazide	0.4	0.6	1.6	-0.4	-0.6	-1.1	-1.3	-0.3	-0.2	-0.8
Medication: Atorvastatin	0.4	0.5	1.6	0.5	1.0	-1.3	-0.1	-0.9	0.1	-0.3
Arm fat-free mass (left)	0.4	2.0	6.1	2.5	1.0	-2.0	-0.1	-0.6	-1.6	0.0
Unable to work because of sickness or disability	0.4	0.5	1.3	-0.2	1.2	-0.6	0.2	-0.8	-0.8	-0.6
Commuting to job workplace: Cycle	0.4	0.5	1.0	0.5	1.0	-0.5	0.5	-1.0	-0.9	-0.4
Leg fat mass (left)	0.4	1.5	3.8	2.0	0.1	-1.2	-1.0	-1.3	-1.4	-0.8
Arm predicted mass (left)	0.4	2.0	5.5	2.4	1.1	-2.2	0.0	-0.5	-1.4	0.2
Depression (Nagel 2018)	0.3	0.5	1.3	-0.8	-0.6	-0.8	-1.1	0.2	0.1	-0.7
Neuroticism (Nagel 2018)	0.3	0.7	3.9	0.3	-0.9	-2.0	0.1	0.1	0.5	0.3
Lupus	0.3	0.5	1.6	-1.3	-0.3	0.6	-0.8	0.8	0.3	0.1
Schizophrenia (2014)	0.3	0.7	3.4	0.2	-0.7	-1.9	0.7	-0.3	0.3	0.0
Blood Platelet Count	0.3	3.4	16.6	-4.1	1.6	-1.8	0.2	0.3	0.8	0.4
Waist Hip Ratio (WHR)	0.3	1.4	4.3	-0.3	-0.6	-2.1	-0.4	-1.7	0.1	-1.5
Ever had hysterectomy (womb removed)	0.3	0.3	1.4	-1.2	-0.4	0.4	-0.3	-0.1	0.6	0.4
Systolic blood pressure, automated reading	0.3	1.0	3.0	0.7	0.6	-0.4	-1.7	-0.7	0.3	-1.4
Pack years adult smoking proportion	0.3	0.5	3.0	-0.2	-1.7	-0.1	-0.5	-0.2	-0.2	-0.2
Impedance of leg (right)	0.3	1.3	4.8	-1.4	-0.3	2.2	0.5	0.4	1.4	0.2
Leg fat-free mass (left)	0.3	1.6	5.3	2.3	1.0	-1.9	0.1	-0.4	-1.2	0.1
Trunk fat percentage	0.3	1.0	2.7	1.6	-0.7	-0.4	-0.9	-1.3	-0.2	-1.2
Hand grip strength (right)	0.3	0.9	2.0	1.3	0.5	-0.8	1.2	0.4	-1.4	0.3
Average weekly fortified wine intake	0.3	0.4	1.3	-0.6	0.1	0.6	-1.2	-0.5	-0.2	-0.2
Serious illness, injury or assault to yourself	0.3	0.4	1.8	0.4	0.5	-1.4	0.2	-0.6	0.1	-0.5
High blood pressure	0.3	0.9	3.0	0.0	0.2	-1.6	-1.7	-0.1	-0.2	-0.8
Medication: Atenolol	0.3	0.4	0.7	-0.4	-0.8	-0.8	-0.6	0.6	0.6	-0.4
Impedance of leg (left)	0.3	1.6	6.2	-1.3	-0.7	2.5	0.6	0.8	1.4	0.3
Leg predicted mass (left)	0.3	1.8	5.8	2.4	1.1	-1.9	0.1	-0.4	-1.2	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	-0.2	0.6	-0.9	-0.9	-0.3	0.1	-0.9
Hair/balding pattern: Pattern 2	0.3	0.4	1.0	1.0	-1.0	-0.4	0.0	0.3	0.0	-0.6
Medication: Ramipril	0.3	0.4	1.3	-0.5	0.1	0.4	-0.9	0.4	1.1	-0.0
Arm fat percentage (right)	0.3	1.0	2.7	1.6	-0.7	-0.8	-1.0	-1.3	-0.2	-0.9
Trunk fat-free mass	0.3	1.6	4.5	2.1	0.9	-1.9	0.4	-0.1	-1.5	0.5
Hair/balding pattern: Pattern 3	0.3	0.4	1.7	-1.3	-0.5	0.6	0.1	0.8	-0.1	0.4
Number of live births	0.3	0.4	1.7	0.5	-0.4	-1.3	0.1	-0.6	-0.0	-0.5
Impedance of arm (left)	0.3	1.5	6.3	-1.3	-0.3	2.5	0.2	0.1	1.5	-0.5
Trunk predicted mass	0.3	1.5	4.4	2.1	0.8	-1.8	0.4	-0.0	-1.4	0.5
Body fat percentage	0.3	1.1	2.2	1.3	-0.5	-0.4	-1.3	-1.5	-0.7	-1.3
Medication: Blood pressure	0.3	0.5	2.2	-0.2	-0.3	-0.6	-1.5	0.6	0.8	0.3
Leg pain on walking	0.3	0.3	1.1	-0.7	0.3	0.4	-0.2	1.1	0.6	0.0
Whole body fat-free mass	0.3	1.7	5.5	2.3	0.9	-1.9	0.3	-0.0	-1.3	0.4
Leg fat-free mass (right)	0.3	1.5	5.4	2.3	0.8	-1.7	0.3	-0.1	-1.1	0.3
Mood swings	0.3	0.5	1.7	-0.1	-1.3	-0.7	0.0	0.6	0.9	0.7
Qualifications: nursing, teaching	0.3	0.4	0.9	0.3	0.9	0.2	0.3	0.9	0.8	0.7
Medication for cholesterol	0.3	0.5	2.2	0.1	1.5	0.7	0.4	0.4	0.2	0.8
Whole body water mass	0.3	1.6	4.8	2.2	1.0	-1.9	0.4	-0.1	-1.2	0.5
Leg predicted mass (right)	0.3	1.4	5.3	2.3	0.9	-1.6	0.3	-0.0	-1.0	0.3
Arm fat mass (left)	0.3	1.2	3.0	1.7	-0.4	-1.3	-0.9	-1.1	-0.8	-0.8
Eye problems/disorders: Glaucoma	0.3	0.4	1.0	-0.1	-0.6	-0.1	-0.0	-1.0	-0.6	-1.0
Medication: Paracetamol	0.3	0.4	1.0	-0.8	-0.2	-0.2	0.7	0.4	1.0	0.8
Basal metabolic rate	0.3	1.6	5.6	2.4	0.9	-1.8	0.2	-0.3	-1.2	0.2
Diastolic blood pressure, automated reading	0.3	1.0	3.8	-0.9	-0.0	0.7	-1.9	-0.5	-0.5	-1.1
Ever depressed for a whole week	0.3	0.4	2.1	1.4	0.2	-0.3	0.8	-0.3	-0.1	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.3	0.3	0.1	1.1	1.8	-0.0	0.7	0.7
Impedance of whole body	0.3	1.5	6.9	-1.1	-0.6	2.6	0.2	0.3	1.4	-0.2
Alzheimer’s Disease (in father)	0.2	0.2	0.7	0.0	-0.2	0.0	0.8	-0.3	-0.8	-0.2
Crohns Disease (2017)	0.2	0.5	2.0	1.4	-0.1	0.1	0.6	-0.8	0.1	-0.4
Coronary Artery Disease (CAD)	0.2	0.2	0.7	-0.0	-0.4	0.4	-0.1	0.3	0.8	0.5
Blood Red Count	0.2	2.0	5.4	2.3	-0.2	-1.8	0.7	-1.9	-0.8	-1.0
BMI	0.2	1.0	2.1	1.4	-1.1	-1.4	-0.7	-1.2	-0.3	-0.1
Height	0.2	3.5	11.0	1.5	3.3	-1.6	-0.8	-2.0	-1.1	-1.7
Cardiovascular Disease	0.2	0.5	1.3	-1.1	0.9	-0.7	-0.6	0.4	0.4	0.6
Neuroticism	0.2	0.4	1.2	0.6	-0.8	-1.1	-0.0	0.1	0.6	0.3
Chronotype (morning person)	0.2	0.5	2.3	-1.5	0.2	1.0	-0.3	0.1	0.2	0.5
Number of treatments/medications taken	0.2	0.4	1.6	-0.1	-0.6	-1.3	0.1	0.5	0.9	0.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.0	-0.3	0.5	-0.3	0.5	0.8	1.0	0.1
Maternal smoking around birth	0.2	0.3	1.5	-1.2	0.1	0.6	-0.4	0.0	0.1	-0.2
Fed-up feelings	0.2	0.3	0.8	0.1	-0.2	-0.5	0.5	0.9	0.6	0.7
Supplements: Glucosamine	0.2	0.3	0.7	0.8	0.0	-0.1	-0.8	-0.1	-0.4	-0.6
Trunk fat mass	0.2	1.1	3.4	1.8	-0.4	-0.7	-0.8	-1.2	-0.8	-0.9
Hearing difficulty/problems with background noise	0.2	0.4	0.9	0.9	0.5	-0.1	0.7	-0.6	-0.5	-0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.2	1.1	0.3	-0.4	0.1	-0.4	-0.4	0.2
Neuroticism score	0.2	0.5	1.6	-0.0	-0.1	-1.2	0.5	0.3	1.0	0.7
Impedance of arm (right)	0.2	1.1	4.0	-1.0	-0.4	2.0	-0.1	0.0	1.6	-0.5
Alcohol intake versus 10 years previously	0.2	0.2	0.6	-0.2	-0.0	0.8	-0.3	0.6	0.6	0.5
Father’s age at death	0.2	0.3	1.9	-0.2	1.4	-0.2	0.5	-0.1	0.0	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	-0.1	1.1	-0.2	-0.8	-0.2	-0.7	-0.3
Pulse rate	0.2	0.3	1.0	-1.0	-0.6	0.7	-0.7	-0.3	0.1	-0.1
Hair/balding pattern: Pattern 4	0.2	0.6	1.3	-0.4	1.2	0.2	0.8	0.9	0.5	0.9
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.7	0.6	0.5	0.2	0.2	-0.4	-0.0
Medication: Paracetamol	0.2	0.3	1.2	-0.9	-0.4	-0.2	0.1	-0.1	1.1	0.2
Headache pain in last month	0.2	0.3	0.7	0.3	0.3	0.5	-0.7	-0.8	-0.3	-0.5
Glaucoma (self-reported)	0.2	0.2	0.8	-0.3	-0.9	-0.5	0.3	-0.0	0.5	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.0	-0.3	-0.5	0.2	-0.2	0.2	-0.3	1.0
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.9	0.4	0.5	-0.9	0.0	-0.1	0.4	-0.5
Alcohol intake frequency.	0.2	0.5	1.7	-0.0	0.6	-1.3	0.2	0.5	0.3	0.9
Overall health rating	0.2	0.5	1.5	0.6	0.8	-1.2	-0.6	-0.2	-0.5	-0.7
Arm fat percentage (left)	0.2	0.9	1.9	1.4	-0.9	-0.5	-0.9	-1.2	-0.4	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.7	-0.6	-0.2	0.4	0.5	0.1	0.8	0.2
Miserableness	0.2	0.3	0.9	0.3	-0.3	0.2	-0.7	0.9	-0.0	0.5
Guilty feelings	0.2	0.3	0.8	-0.7	0.4	0.4	0.1	0.9	0.5	0.4
Medication: Blood pressure	0.2	0.4	1.5	0.5	-1.2	-1.0	0.4	0.2	0.2	-0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.0	0.4	0.6	-1.0	-0.1	0.2	0.5	-0.0
High cholesterol (Self-reported)	0.2	0.4	1.1	-1.0	0.1	0.1	-0.2	0.6	0.9	0.6
Cholesterol lowering medication	0.2	0.3	1.1	-0.4	0.8	0.4	-1.0	0.4	-0.1	-0.3
Systolic Blood Pressure	0.1	0.6	2.0	0.9	0.2	-1.1	0.2	0.2	1.4	-0.0
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	-0.7	-0.4	0.3	0.5	0.2	0.4	0.1
Stomach or abdominal pain in last month	0.1	0.1	0.4	-0.0	-0.1	0.3	-0.2	0.6	-0.3	0.3
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	0.7	-0.3	-0.4	-0.5	0.1	0.5	-0.2
Standing height	0.1	1.1	3.1	1.2	1.4	0.1	1.8	0.5	-0.6	0.9
Comparative body size at age 10	0.1	0.3	1.2	-1.1	-0.3	-0.5	-0.1	0.4	-0.5	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	0.0	-0.4	0.7	0.4	0.2	0.1	0.2
Comparative height size at age 10	0.1	0.3	0.5	0.7	-0.0	0.4	0.7	0.6	-0.4	0.5
Hair Pigment	0.0	0.4	1.1	-0.5	0.1	1.1	0.0	-0.9	0.3	-0.5
Tanning	0.0	0.3	0.8	-0.1	-0.1	-0.8	-0.3	-0.9	-0.7	-0.3
Qualifications: College or University degree	0.0	0.1	0.2	0.4	0.3	-0.4	-0.4	-0.0	0.0	-0.1

Hub : Genes

FPR3

Models

Trait associations