Hub : Genes

FPR3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.6250	0.0660	5.8e-10	0.584	NA	0.516	NA	0.576	2.5e-31	NA	2.8e-26	NA	9.7e-31
2	GTEx	Whole Blood	0.1290	0.0530	2.6e-03	0.014	NA	0.000	NA	0.008	1.8e-02	NA	3.4e-01	NA	5.4e-02
3	YFS	Blood	0.1472	0.0225	0.0e+00	0.048	0.078	0.100	0.105	0.102	2.3e-15	3.9e-24	8.5e-31	2.2e-32	1.1e-31
4	TCGA	Lung Adenocarcinoma	0.0505	0.0262	3.3e-03	0.013	0.008	0.013	NA	0.018	9.1e-03	3.2e-02	9.9e-03	NA	2.7e-03
5	TCGA	Lung Squamous Cell Carcinoma	0.0519	0.0247	3.6e-03	0.031	0.023	0.013	NA	0.023	1.7e-04	1.0e-03	1.2e-02	NA	1.1e-03
6	TCGA	Pancreatic Adenocarcinoma	0.1750	0.0730	1.6e-03	0.096	0.032	0.019	NA	0.066	8.2e-05	1.7e-02	5.3e-02	NA	9.7e-04
7	TCGA	Stomach Adenocarcinoma	0.0690	0.0350	8.3e-03	-0.003	0.003	-0.003	NA	-0.003	7.5e-01	1.9e-01	6.0e-01	NA	6.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.7	2.4	0.2	-0.8	-1.5	-0.0	-0.8	-1.1	-0.4
Bipolar Disorder or Schizophrenia	0.4	0.9	4.2	0.5	-0.0	-2.1	1.0	-0.1	0.5	0.7
Depressed Affect (Nagel 2018)	0.4	0.9	1.8	1.0	-0.8	-1.4	0.7	1.1	0.3	1.2
Depression (Nagel 2018)	0.3	0.5	1.3	-0.8	-0.6	-0.8	-1.1	0.2	0.1	-0.7
Intelligence (Savage-Jansen 2018)	0.5	1.7	4.3	-0.1	0.8	1.6	-2.1	-0.7	-1.8	-0.8
Neuroticism (Nagel 2018)	0.3	0.7	3.9	0.3	-0.9	-2.0	0.1	0.1	0.5	0.3
Schizophrenia (2018)	0.6	1.2	2.2	0.4	0.6	-1.4	1.3	0.5	1.5	1.2
Schizophrenia vs Biploar Disorder	0.4	0.6	1.4	0.7	-0.1	0.4	1.2	0.6	1.2	0.4
Worry (Nagel 2018)	0.9	1.9	3.9	-1.3	-0.3	-1.1	0.8	1.6	1.8	2.0
Alzheimer’s Disease (in mother)	1.1	1.3	2.1	0.8	-1.1	1.4	0.6	1.2	1.2	1.4
Alzheimer’s Disease (in father)	0.2	0.2	0.7	0.0	-0.2	0.0	0.8	-0.3	-0.8	-0.2
Alzheimer’s Disease (including proxy)	1.0	1.5	5.1	0.2	-2.0	2.2	0.5	0.7	0.6	0.7
Crohns Disease (2017)	0.2	0.5	2.0	1.4	-0.1	0.1	0.6	-0.8	0.1	-0.4
Irritable Bowel Disease (IBD)	0.5	1.2	3.6	0.4	0.5	-1.0	-0.9	-1.4	-0.9	-1.9
Ulcerative Colitis (UC)	1.1	2.0	4.8	-0.5	0.8	-1.8	-1.6	-1.1	-1.2	-2.2
Major Depression (MDD)	0.7	0.9	2.5	1.6	-0.6	1.1	0.3	0.7	0.1	1.1
Reaction Time	0.4	0.8	1.5	-1.0	-1.2	0.7	0.0	1.0	1.1	0.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.6	1.1	1.9	0.7	-0.9	-0.4	-0.9	0.0
Breast Cancer	0.8	1.9	4.8	1.3	-0.1	0.5	2.2	1.5	1.2	1.7
Ovarian Cancer	1.2	1.6	3.4	1.4	-0.3	-1.8	-0.2	-1.4	-1.3	-1.4
Prostate Cancer	1.1	1.6	4.0	2.0	-1.3	-0.8	-0.3	-1.9	-0.2	-1.2
Age at First Birth	1.0	1.4	3.0	1.1	-1.7	0.3	1.5	0.9	-0.5	1.4
Bipolar Disorder (2011)	0.5	0.4	1.6	-0.3	0.0	1.2	-0.6	-0.5	-0.6	-0.6
Body Mass Index (BMI) (2010)	1.1	1.5	2.7	-1.5	-1.6	0.5	1.3	1.0	1.5	0.6
Coronary Artery Disease (CAD)	0.2	0.2	0.7	-0.0	-0.4	0.4	-0.1	0.3	0.8	0.5
Crohns Disease (2012)	0.5	0.8	1.6	1.1	-0.9	-0.3	1.3	-1.2	0.3	-0.3
Mean Putamen Volume	0.8	0.9	2.8	0.9	1.0	-0.5	1.7	-0.2	0.9	0.7
Fasting Glucose	1.2	1.4	3.4	-1.1	-1.4	0.9	-1.9	-0.6	-0.7	-1.3
HbA1C	0.4	0.4	1.2	-0.1	-1.1	0.9	0.9	-0.1	-0.2	-0.1
HDL Cholesterol	8.8	14.6	27.6	3.4	-1.6	-1.6	-3.4	-4.8	-5.2	-4.8
LDL Cholesterol	1.1	1.7	6.6	0.6	0.4	0.7	-1.0	-1.2	-2.6	-1.3
Lupus	0.3	0.5	1.6	-1.3	-0.3	0.6	-0.8	0.8	0.3	0.1
Neuroticism (2016)	0.6	0.9	2.5	0.7	-1.4	-1.6	-0.5	-0.3	0.1	-0.9
Primary Biliary Cirrhosis	2.6	3.6	5.6	1.4	-1.7	-2.4	-1.4	-1.8	-2.1	-2.3
Rheumatoid Arthritis	0.6	0.9	4.0	-0.3	2.0	-1.1	0.1	-0.8	0.3	-0.3
Schizophrenia (2014)	0.3	0.7	3.4	0.2	-0.7	-1.9	0.7	-0.3	0.3	0.0
Triglycerides	0.4	0.7	2.3	-1.5	0.3	0.6	0.2	1.0	0.7	0.9
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.6	-0.8	1.2	-0.2	-0.2	0.2	1.3	0.7
Ulcerative Colitis	0.7	1.0	1.9	-1.4	1.0	-0.7	-0.9	-0.9	-0.3	-1.2
Blood Eosinophil Count	4.4	34.2	59.9	-0.3	-0.2	-6.2	-7.7	-7.4	-5.3	-7.7
Blood Platelet Count	0.3	3.4	16.6	-4.1	1.6	-1.8	0.2	0.3	0.8	0.4
Blood Red Count	0.2	2.0	5.4	2.3	-0.2	-1.8	0.7	-1.9	-0.8	-1.0
Blood White Count	0.4	2.8	16.0	-0.4	1.4	-4.0	0.3	-0.7	-0.7	-0.4
Heel T-Score	1.9	14.9	26.8	-2.7	-1.1	4.3	2.9	4.5	4.8	5.2
BMI	0.2	1.0	2.1	1.4	-1.1	-1.4	-0.7	-1.2	-0.3	-0.1
Height	0.2	3.5	11.0	1.5	3.3	-1.6	-0.8	-2.0	-1.1	-1.7
Waist Hip Ratio (WHR)	0.3	1.4	4.3	-0.3	-0.6	-2.1	-0.4	-1.7	0.1	-1.5
Systolic Blood Pressure	0.1	0.6	2.0	0.9	0.2	-1.1	0.2	0.2	1.4	-0.0
Smoking Status	0.7	1.8	8.9	0.8	3.0	-1.3	0.9	0.3	-0.5	0.2
Allergy or Eczema	2.2	5.8	13.1	-1.1	-0.2	-1.2	-3.6	-3.3	-1.3	-3.5
Cardiovascular Disease	0.2	0.5	1.3	-1.1	0.9	-0.7	-0.6	0.4	0.4	0.6
Hypothyroidism (self reported)	0.7	1.6	3.3	-0.4	1.6	0.0	1.8	1.4	1.5	1.1
Respiratory disease	3.2	7.0	13.4	-0.7	-0.4	-3.3	-3.3	-3.1	-2.0	-3.7
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.1	1.8	1.3	-1.5	-0.1	-1.5	-0.3	-1.1
Lung FEV1/FVC ratio	3.0	15.0	61.3	-7.8	-0.0	4.0	-1.6	3.0	3.9	1.4
Lung FVC	0.9	4.8	13.7	-0.4	2.6	0.5	2.3	1.7	2.1	3.7
Neuroticism	0.2	0.4	1.2	0.6	-0.8	-1.1	-0.0	0.1	0.6	0.3
Chronotype (morning person)	0.2	0.5	2.3	-1.5	0.2	1.0	-0.3	0.1	0.2	0.5
Hair Pigment	0.0	0.4	1.1	-0.5	0.1	1.1	0.0	-0.9	0.3	-0.5
Tanning	0.0	0.3	0.8	-0.1	-0.1	-0.8	-0.3	-0.9	-0.7	-0.3
Hand grip strength (left)	0.4	1.0	2.7	0.6	1.6	-1.3	0.9	0.7	-0.6	0.8
Number of treatments/medications taken	0.2	0.4	1.6	-0.1	-0.6	-1.3	0.1	0.5	0.9	0.2
Average weekly spirits intake	1.3	1.6	5.0	2.2	0.7	-2.1	-0.5	-0.7	-0.4	-0.9
Sensitivity / hurt feelings	1.4	2.4	5.7	0.2	0.7	-2.0	-1.3	-2.4	-0.1	-2.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.0	-0.3	0.5	-0.3	0.5	0.8	1.0	0.1
Hearing difficulty/problems: Yes	0.4	0.6	1.8	0.5	1.4	-0.4	1.1	-0.6	-0.0	-0.1
Relative age of first facial hair	0.7	1.5	4.7	0.3	-0.8	-0.5	-1.1	-2.2	-0.7	-1.7
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.9	-0.8	0.3	0.0	0.8	1.7	1.4	0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	-0.7	-0.4	0.3	0.5	0.2	0.4	0.1
Ever had hysterectomy (womb removed)	0.3	0.3	1.4	-1.2	-0.4	0.4	-0.3	-0.1	0.6	0.4
Systolic blood pressure, automated reading	0.3	1.0	3.0	0.7	0.6	-0.4	-1.7	-0.7	0.3	-1.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.0	0.1	1.4	-1.3	-1.1	-0.7	-0.7	-0.6
Angina	0.6	0.7	1.8	-0.3	-1.2	-0.3	1.4	0.9	-0.1	1.0
Medication for hormone replacement therapy	0.5	0.6	2.4	0.5	-1.6	0.1	-0.2	-0.5	-0.3	-1.0
Vitamin and mineral supplements	1.2	1.6	3.0	1.4	1.1	-0.0	-1.0	-1.5	-1.7	-1.2
Supplements: Zinc	0.6	0.7	2.7	-1.7	-0.2	-1.1	-0.3	0.8	0.0	0.4
Medication: Co-codamol	0.4	0.4	1.9	-1.4	0.3	-0.5	-0.4	-0.2	0.7	-0.3
Medication: Metformin	1.6	2.3	7.9	2.8	-0.2	-1.4	-0.2	-1.8	-0.9	-1.5
Diabetes (father)	0.9	1.1	3.8	1.5	0.1	-0.6	0.5	-0.5	2.0	-0.6
Diabetes (mother)	0.5	0.6	1.4	-0.0	0.2	-1.0	0.6	-1.2	-1.1	-0.6
Severe depression (siblings)	0.8	0.9	2.5	-1.2	-0.3	-0.1	0.1	1.6	1.3	0.8
Pack years adult smoking proportion	0.3	0.5	3.0	-0.2	-1.7	-0.1	-0.5	-0.2	-0.2	-0.2
Impedance of leg (right)	0.3	1.3	4.8	-1.4	-0.3	2.2	0.5	0.4	1.4	0.2
Leg fat-free mass (left)	0.3	1.6	5.3	2.3	1.0	-1.9	0.1	-0.4	-1.2	0.1
Trunk fat percentage	0.3	1.0	2.7	1.6	-0.7	-0.4	-0.9	-1.3	-0.2	-1.2
Hand grip strength (right)	0.3	0.9	2.0	1.3	0.5	-0.8	1.2	0.4	-1.4	0.3
Townsend deprivation index at recruitment	0.8	1.2	2.8	0.9	1.7	-1.6	-0.1	-0.8	-0.7	-1.0
Current tobacco smoking	1.0	1.6	4.8	2.0	0.1	-0.4	0.2	-1.2	-2.2	-1.1
Average weekly fortified wine intake	0.3	0.4	1.3	-0.6	0.1	0.6	-1.2	-0.5	-0.2	-0.2
Maternal smoking around birth	0.2	0.3	1.5	-1.2	0.1	0.6	-0.4	0.0	0.1	-0.2
Fed-up feelings	0.2	0.3	0.8	0.1	-0.2	-0.5	0.5	0.9	0.6	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.1	-0.8	-0.5	-0.7	-1.0	0.0	-0.2	-1.1
Relative age voice broke	0.4	0.7	1.8	1.0	-0.5	-1.3	0.0	-0.6	1.0	-0.5
Taking other prescription medications	0.9	1.4	4.8	1.5	0.1	-2.2	-0.2	-1.1	0.6	-1.0
Age when periods started (menarche)	1.0	2.3	5.6	0.4	1.0	0.8	-1.9	-1.9	-1.3	-2.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.0	0.4	-1.2	0.5	1.4	-0.2	0.6	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	7.0	-1.1	0.2	1.1	2.0	1.2	1.8	2.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	-0.6	-0.3	-0.7	0.8	0.6	0.3	0.7
Qualifications: CSEs or equivalent	0.5	0.7	1.7	1.3	1.3	-0.5	0.4	-0.6	-0.6	-0.3
Serious illness, injury or assault to yourself	0.3	0.4	1.8	0.4	0.5	-1.4	0.2	-0.6	0.1	-0.5
High blood pressure	0.3	0.9	3.0	0.0	0.2	-1.6	-1.7	-0.1	-0.2	-0.8
Hayfever, allergic rhinitis or eczema	2.3	4.9	9.9	-0.7	-0.8	-1.9	-3.1	-2.8	-1.5	-3.1
Multivitamins +/- minerals	1.7	2.1	4.6	-1.0	-0.2	0.5	1.5	2.1	2.0	1.7
Stomach or abdominal pain in last month	0.1	0.1	0.4	-0.0	-0.1	0.3	-0.2	0.6	-0.3	0.3
Supplements: Glucosamine	0.2	0.3	0.7	0.8	0.0	-0.1	-0.8	-0.1	-0.4	-0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.7	-0.1	0.5	-1.3	0.5	-0.7	-0.1	-0.3
Medication: Atenolol	0.3	0.4	0.7	-0.4	-0.8	-0.8	-0.6	0.6	0.6	-0.4
Medication: Levothyroxine sodium	1.0	1.7	3.5	0.1	0.9	0.7	1.9	1.7	1.2	1.7
Sitting height	0.5	3.9	10.2	0.1	1.6	0.5	2.3	2.9	0.9	3.2
Chronic bronchitis/emphysema (father)	1.3	1.5	6.8	0.4	-2.6	-1.0	0.8	-0.8	-1.1	-0.4
High blood pressure (mother)	0.6	0.9	3.3	0.7	0.7	-0.3	0.8	0.2	1.8	1.0
Body mass index (BMI)	0.5	2.2	5.0	2.2	-0.2	-2.2	-1.0	-1.5	-1.2	-0.9
Impedance of leg (left)	0.3	1.6	6.2	-1.3	-0.7	2.5	0.6	0.8	1.4	0.3
Leg predicted mass (left)	0.3	1.8	5.8	2.4	1.1	-1.9	0.1	-0.4	-1.2	0.0
Trunk fat mass	0.2	1.1	3.4	1.8	-0.4	-0.7	-0.8	-1.2	-0.8	-0.9
Waist circumference	0.6	2.3	5.4	2.1	-0.2	-2.3	-1.1	-1.8	-1.0	-1.2
Number of incorrect matches in round	0.8	1.4	4.7	-2.2	1.5	-1.1	0.0	1.0	0.4	0.7
Past tobacco smoking	0.9	1.7	5.2	-0.8	-2.3	2.2	0.4	0.4	0.8	0.7
Alcohol usually taken with meals	0.5	0.8	2.1	-1.2	0.3	-0.0	-1.4	-0.8	-0.9	-0.9
Nervous feelings	0.7	1.3	3.5	-0.6	-0.5	-1.0	1.2	0.8	1.9	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	-0.2	0.6	-0.9	-0.9	-0.3	0.1	-0.9
Hearing difficulty/problems with background noise	0.2	0.4	0.9	0.9	0.5	-0.1	0.7	-0.6	-0.5	-0.8
Hair/balding pattern: Pattern 2	0.3	0.4	1.0	1.0	-1.0	-0.4	0.0	0.3	0.0	-0.6
Had menopause	0.7	0.8	1.7	0.3	0.2	-0.7	-1.1	-1.1	-1.3	-0.9
Had other major operations	0.5	0.6	1.6	-0.1	-0.4	0.7	0.0	0.8	1.2	1.3
Forced vital capacity (FVC)	0.5	2.1	6.2	1.1	2.5	0.1	1.3	0.6	0.7	2.1
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	4.9	-1.4	1.3	0.3	1.7	0.9	2.2	2.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.2	1.1	0.3	-0.4	0.1	-0.4	-0.4	0.2
Qualifications: None of the above	0.4	0.8	2.2	-1.2	0.0	-1.1	0.3	-1.5	0.0	-0.9
Financial difficulties in last 2 years	0.5	0.7	2.5	1.6	-0.0	-1.1	-0.4	-0.7	-0.5	-0.6
Mouth/teeth dental problems	0.6	0.9	1.7	-1.1	-0.8	0.6	0.6	0.9	-1.3	1.1
Heart attack	0.6	0.8	1.6	0.4	0.5	-1.1	-1.0	-1.0	0.2	-1.3
Allergy	4.6	10.7	22.4	-0.2	1.7	3.4	4.2	4.1	1.9	4.7
Pain all over the body in last month	3.2	3.4	6.6	0.2	0.8	-1.9	-2.3	-1.8	-2.1	-2.6
Diabetes (self-reported)	1.0	1.5	3.3	1.8	0.8	-1.7	-0.6	-1.5	-0.3	-1.0
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	4.9	0.9	-0.0	-0.4	-2.2	-2.0	-0.8	-1.9
Medication: Ramipril	0.3	0.4	1.3	-0.5	0.1	0.4	-0.9	0.4	1.1	-0.0
Medication: Simvastatin	1.0	1.4	3.2	-1.4	-0.5	1.6	-0.7	1.8	0.9	0.8
Fluid intelligence score	0.9	1.9	4.4	1.7	2.1	0.5	-1.4	-1.0	-1.5	-0.8
Illnesses of siblings	0.8	1.1	3.2	1.8	-1.2	-0.5	1.3	0.1	-1.1	0.3
Neuroticism score	0.2	0.5	1.6	-0.0	-0.1	-1.2	0.5	0.3	1.0	0.7
Weight	0.4	2.0	6.5	2.5	0.5	-1.9	-0.1	-1.1	-1.4	-0.4
Impedance of arm (right)	0.2	1.1	4.0	-1.0	-0.4	2.0	-0.1	0.0	1.6	-0.5
Arm fat percentage (right)	0.3	1.0	2.7	1.6	-0.7	-0.8	-1.0	-1.3	-0.2	-0.9
Trunk fat-free mass	0.3	1.6	4.5	2.1	0.9	-1.9	0.4	-0.1	-1.5	0.5
Hip circumference	0.4	1.7	7.8	2.8	0.5	-1.3	-0.7	-0.5	-1.1	-0.1
Time employed in main current job	0.5	0.6	1.4	-0.1	-0.2	0.7	1.2	1.0	0.5	0.9
Alcohol intake versus 10 years previously	0.2	0.2	0.6	-0.2	-0.0	0.8	-0.3	0.6	0.6	0.5
Father’s age at death	0.2	0.3	1.9	-0.2	1.4	-0.2	0.5	-0.1	0.0	-0.4
Worrier / anxious feelings	0.4	0.7	1.8	-0.2	-1.2	-1.4	-0.4	0.4	1.0	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	-0.1	1.1	-0.2	-0.8	-0.2	-0.7	-0.3
Falls in the last year	1.0	1.3	2.9	0.3	-1.1	0.0	-1.2	-1.4	-1.3	-1.7
Hair/balding pattern: Pattern 3	0.3	0.4	1.7	-1.3	-0.5	0.6	0.1	0.8	-0.1	0.4
Number of live births	0.3	0.4	1.7	0.5	-0.4	-1.3	0.1	-0.6	-0.0	-0.5
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	8.2	-0.7	2.4	1.0	1.4	1.9	2.0	2.9
Pulse rate	0.2	0.3	1.0	-1.0	-0.6	0.7	-0.7	-0.3	0.1	-0.1
Happiness	4.0	4.9	8.8	1.2	1.0	-1.4	-2.6	-2.7	-2.8	-3.0
Noisy workplace	0.7	0.9	1.6	1.3	0.6	-1.0	-0.9	-1.0	-0.7	-1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.7	-0.8	1.9	1.4	-0.8	0.5	0.5	0.4
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	4.1	1.0	2.0	0.0	0.7	0.7	1.5	1.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	0.7	-0.3	-0.4	-0.5	0.1	0.5	-0.2
Asthma	5.9	11.6	24.3	0.6	-0.1	-4.0	-3.9	-4.5	-2.2	-4.9
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	7.5	-0.8	-0.4	0.4	1.6	2.4	1.3	2.7
Medication: Cholesterol lowering	0.5	0.7	2.7	-0.2	-0.5	0.3	-0.0	1.1	1.6	0.9
Depression (self-reported)	0.6	0.7	1.5	0.7	1.2	1.0	0.7	0.4	0.4	0.9
Medication: Lansoprazole	0.6	0.7	2.5	-0.3	0.0	-0.6	-0.5	-1.2	-0.1	-1.6
Prospective memory result	1.9	2.4	6.3	-1.3	-0.3	-0.7	1.5	2.0	2.5	1.4
Lung cancer (father)	1.2	1.4	4.7	1.7	-0.6	-2.2	0.5	-0.9	-0.5	-0.5
Illnesses of mother	3.0	3.7	9.6	-1.1	-1.5	-1.2	-2.2	-1.5	-3.1	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.0	15.3	-0.8	3.9	0.4	1.9	2.4	2.1	3.5
Pulse wave Arterial Stiffness index	0.9	1.0	2.3	1.4	0.4	-1.5	-0.9	-0.3	-0.9	-1.0
Impedance of arm (left)	0.3	1.5	6.3	-1.3	-0.3	2.5	0.2	0.1	1.5	-0.5
Arm fat mass (right)	0.4	1.5	4.4	2.1	-0.3	-1.5	-0.8	-1.4	-0.8	-0.9
Trunk predicted mass	0.3	1.5	4.4	2.1	0.8	-1.8	0.4	-0.0	-1.4	0.5
Standing height	0.1	1.1	3.1	1.2	1.4	0.1	1.8	0.5	-0.6	0.9
Length of working week for main job	0.6	0.7	1.3	0.6	-0.3	-0.2	-1.0	-1.1	-0.9	-1.1
Exposure to tobacco smoke at home	0.7	0.8	1.8	1.4	0.4	-0.5	1.3	0.6	0.8	0.8
Breastfed as a baby	1.6	2.0	3.4	0.2	-1.8	-0.7	-1.5	-1.8	-1.4	-1.6
Tense / ‘highly strung’	2.3	3.8	11.6	-0.9	1.2	0.1	2.1	1.8	3.4	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.1	1.0	1.1	-1.0	0.5	0.4	0.0	0.9
Hair/balding pattern: Pattern 4	0.2	0.6	1.3	-0.4	1.2	0.2	0.8	0.9	0.5	0.9
Birth weight of first child	1.1	2.0	5.4	-2.3	-0.2	0.8	-1.8	-1.1	-1.6	-1.0
Peak expiratory flow (PEF)	0.8	1.8	3.7	-0.3	1.9	-0.9	0.9	1.2	1.4	1.9
Pulse wave reflection index	0.8	0.9	2.4	0.8	1.2	-1.6	-0.2	-0.4	-1.3	-0.4
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.7	0.6	0.5	0.2	0.2	-0.4	-0.0
Loud music exposure frequency	1.2	1.3	4.3	2.1	0.0	-1.1	1.8	0.4	-0.3	0.4
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.6	0.9	0.1	1.6	0.3	1.9	1.4	1.8
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.1	-0.8	1.0	1.8	0.1	0.5	1.5	0.4
Blood clot in the leg (DVT)	0.9	1.1	2.4	1.5	-1.5	-0.4	-0.4	-1.2	-0.4	-1.2
Medication: Paracetamol	0.2	0.3	1.2	-0.9	-0.4	-0.2	0.1	-0.1	1.1	0.2
Headache pain in last month	0.2	0.3	0.7	0.3	0.3	0.5	-0.7	-0.8	-0.3	-0.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.4	0.6	-0.1	0.1	1.1	-1.2	-1.6	-0.9
Glaucoma (self-reported)	0.2	0.2	0.8	-0.3	-0.9	-0.5	0.3	-0.0	0.5	-0.1
Gout (self-reported)	0.4	0.6	1.8	0.2	-0.8	-0.8	-1.3	-0.0	-0.7	-0.7
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	4.2	0.2	1.1	0.3	2.0	1.8	1.4	1.3
Medication: Amlodipine	0.5	0.7	2.9	0.1	1.1	-0.5	0.4	-0.1	1.7	0.2
Medication: Ventolin 100micrograms inhaler	3.9	5.0	10.0	1.0	-0.3	-3.0	-1.9	-3.2	-1.3	-3.1
Birth weight	1.1	2.4	12.9	-3.6	-0.8	1.0	-0.9	0.9	0.5	0.2
Chronic bronchitis/emphysema (mother)	1.3	1.5	5.2	-0.7	0.3	2.3	-1.2	-0.3	1.6	-0.8
High blood pressure (siblings)	0.7	0.9	3.0	-1.7	0.4	0.4	-1.0	0.5	1.5	0.1
Forced vital capacity (FVC), Best measure	1.3	4.9	17.0	1.1	4.1	-0.8	1.9	1.4	0.9	2.9
Body fat percentage	0.3	1.1	2.2	1.3	-0.5	-0.4	-1.3	-1.5	-0.7	-1.3
Leg fat percentage (right)	0.6	2.0	3.3	1.4	-0.0	-0.9	-1.8	-1.8	-1.6	-1.5
Arm fat-free mass (right)	0.4	1.8	5.2	2.3	0.9	-2.0	0.3	-0.1	-1.6	0.3
Exposure to tobacco smoke outside home	0.9	1.2	2.3	-0.4	0.3	-0.9	-1.5	-1.4	-1.4	-1.2
Comparative body size at age 10	0.1	0.3	1.2	-1.1	-0.3	-0.5	-0.1	0.4	-0.5	0.6
Number of full brothers	3.0	3.8	9.0	-0.2	-1.5	-1.3	-1.5	-1.9	-3.0	-2.8
Worry too long after embarrassment	0.4	0.7	2.9	1.1	0.3	-1.7	0.6	-0.3	0.3	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	0.0	-0.4	0.7	0.4	0.2	0.1	0.2
Wheeze or whistling in the chest in last year	2.4	4.3	9.0	1.7	-1.1	-1.7	-2.2	-2.6	-1.4	-3.0
Number of children fathered	1.1	1.2	3.3	-0.1	-1.4	-0.6	-1.8	-0.6	-0.7	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.0	-0.3	-0.5	0.2	-0.2	0.2	-0.3	1.0
Age at first live birth	0.7	1.2	4.2	-0.6	2.1	0.8	0.9	0.5	0.6	1.4
Pulse wave peak to peak time	0.9	1.0	2.5	-1.3	-0.3	1.6	1.0	0.3	0.8	1.0
Health satisfaction	0.7	0.9	3.5	0.0	0.8	0.2	-1.0	-0.6	-1.9	-0.7
Shortness of breath walking on level ground	0.5	0.6	1.6	-0.6	-1.3	0.2	0.5	0.1	1.2	-0.1
Qualifications: College or University degree	0.0	0.1	0.2	0.4	0.3	-0.4	-0.4	-0.0	0.0	-0.1
Eye problems/disorders: None of the above	1.2	1.4	2.3	-0.6	-1.1	1.2	1.2	1.3	1.5	1.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.9	0.4	0.5	-0.9	0.0	-0.1	0.4	-0.5
Emphysema/chronic bronchitis	0.5	0.6	1.1	1.0	-0.8	-0.6	-0.7	-0.4	-0.8	-0.9
Medication for pain relief, constipation, heartburn	0.4	0.7	2.3	0.4	0.5	0.2	-0.4	-1.0	-1.5	-0.9
Neck or shoulder pain in last month	0.6	0.9	3.6	1.9	0.2	-0.6	0.3	-0.9	-1.2	-0.4
Medication: Blood pressure	0.3	0.5	2.2	-0.2	-0.3	-0.6	-1.5	0.6	0.8	0.3
Angina (self-reported)	0.5	0.7	1.4	-0.3	-0.8	-0.3	1.2	1.2	0.2	1.1
Migraine (self-reported)	0.4	0.5	1.5	0.0	0.2	-1.2	-0.9	0.3	0.9	-0.0
Medication: Ibuprofen	1.8	2.2	6.1	-1.3	-0.5	0.3	0.9	2.5	0.5	2.5
Medication: Allopurinol	0.7	0.9	1.9	-0.4	-1.0	-0.7	-1.3	-0.6	-1.4	-1.0
Medication: Omeprazole	1.4	1.7	3.9	-0.8	-1.3	0.8	0.9	2.0	0.8	1.9
Medication: Seretide 50 evohaler	2.8	3.2	6.8	0.6	-2.6	-1.2	-1.4	-1.5	-2.3	-2.1
Mean time to correctly identify matches	0.4	0.7	1.4	-0.9	-1.2	-0.1	-1.0	-0.6	0.2	-1.1
Heart disease (mother)	0.5	0.6	1.4	1.2	-0.3	0.5	1.1	0.7	0.3	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	5.4	-1.0	0.1	0.6	-0.5	0.4	2.3	0.1
Whole body fat mass	0.4	1.6	3.2	1.8	-0.4	-1.0	-1.2	-1.5	-1.2	-1.3
Leg fat mass (right)	0.4	1.7	3.2	1.8	0.4	-1.1	-1.3	-1.5	-1.5	-1.0
Arm predicted mass (right)	0.4	1.9	5.2	2.3	0.7	-2.1	0.2	-0.4	-1.8	0.1
Pulse rate, automated reading	0.4	1.1	7.2	-2.7	0.2	0.2	-0.1	0.0	0.8	0.2
Alcohol intake frequency.	0.2	0.5	1.7	-0.0	0.6	-1.3	0.2	0.5	0.3	0.9
Comparative height size at age 10	0.1	0.3	0.5	0.7	-0.0	0.4	0.7	0.6	-0.4	0.5
Number of full sisters	1.6	2.0	4.1	0.8	1.4	-1.7	-1.4	-1.6	-0.2	-2.0
Suffer from ‘nerves’	1.9	3.0	7.1	-2.7	0.3	0.4	1.3	1.4	2.2	2.3
Overall health rating	0.2	0.5	1.5	0.6	0.8	-1.2	-0.6	-0.2	-0.5	-0.7
Chest pain or discomfort	0.5	0.7	1.9	-0.5	-0.8	-0.2	-1.1	-0.2	-1.4	-0.7
Had major operations	1.7	2.0	4.7	0.3	-0.5	-0.7	-1.9	-1.8	-1.2	-2.2
Age at last live birth	1.7	2.5	5.4	-1.2	0.7	0.9	1.9	1.9	1.4	2.3
Family relationship satisfaction	2.4	3.0	7.8	0.1	1.4	-1.0	-2.3	-1.4	-2.8	-1.7
Leg pain on walking	0.3	0.3	1.1	-0.7	0.3	0.4	-0.2	1.1	0.6	0.0
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.2	1.2	-0.0	-1.7	-1.8	-0.3	-0.1	-1.3
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.7	1.1	-0.1	0.2	0.3	1.3	0.5	0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	3.3	-0.8	-1.8	0.7	-0.4	-0.5	0.4	-0.5
Medication: Aspirin	0.4	0.5	1.4	-0.3	0.8	-0.6	-1.2	0.3	1.0	-0.4
Supplements: Vitamin C	0.8	0.9	4.3	0.6	0.3	-2.1	1.1	0.1	-0.5	0.6
Knee pain experienced in last month	0.6	1.0	2.7	-0.6	-1.0	-0.9	-1.6	-0.9	-0.9	-0.9
Hypertension (Self-reported)	0.5	1.3	3.9	0.1	0.4	-1.8	-2.0	-0.5	-0.2	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.5	-0.5	0.3	-1.0	0.8	1.6	1.4	1.2
Illnesses of father: Heart disease	0.9	1.2	3.1	-1.7	0.3	1.3	-1.8	0.2	0.7	-0.1
Illnesses of siblings: Diabetes	0.6	0.8	1.5	-1.2	0.3	0.7	-0.1	1.1	1.1	1.1
Smoking status: Previous	0.9	1.3	4.9	0.1	2.2	-1.8	0.2	0.4	0.6	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	2.4	0.5	1.5	-0.3	1.0	0.6	-0.5	0.9
Whole body fat-free mass	0.3	1.7	5.5	2.3	0.9	-1.9	0.3	-0.0	-1.3	0.4
Leg fat-free mass (right)	0.3	1.5	5.4	2.3	0.8	-1.7	0.3	-0.1	-1.1	0.3
Arm fat percentage (left)	0.2	0.9	1.9	1.4	-0.9	-0.5	-0.9	-1.2	-0.4	-1.0
Average weekly red wine intake	0.4	0.6	1.2	-0.6	1.1	0.6	-1.1	-0.5	-0.2	-0.6
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.3	1.2	1.4	-0.9	0.8	1.5	0.5	0.9
Mood swings	0.3	0.5	1.7	-0.1	-1.3	-0.7	0.0	0.6	0.9	0.7
Loneliness, isolation	1.2	1.7	6.7	1.7	-0.7	-2.6	-0.1	-0.5	-1.0	-0.7
Long-standing illness, disability or infirmity	0.4	0.6	2.1	1.2	0.5	-1.5	-0.1	-0.1	0.5	-0.1
Ever had bowel cancer screening	0.6	0.7	2.5	0.4	0.0	1.1	0.6	0.5	1.6	0.1
Diabetes diagnosed by doctor	1.0	1.7	4.0	2.0	0.4	-1.4	-0.7	-1.7	-0.2	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.7	-0.6	-0.2	0.4	0.5	0.1	0.8	0.2
Friendships satisfaction	3.5	4.3	7.3	1.6	0.2	-1.3	-2.2	-2.7	-2.7	-2.6
Qualifications: nursing, teaching	0.3	0.4	0.9	0.3	0.9	0.2	0.3	0.9	0.8	0.7
Commuting to job workplace: Walk	1.2	1.3	2.6	-0.6	-0.2	-0.1	-1.4	-1.6	-1.6	-1.3
Eye problems/disorders: Cataract	0.4	0.4	1.4	0.7	1.0	-0.0	-0.1	-0.2	-1.2	0.0
Mouth/teeth dental problems: Mouth ulcers	4.1	6.5	15.9	2.3	1.2	-2.4	-1.7	-4.0	-1.2	-3.6
Medication for cholesterol	0.3	0.5	2.2	0.1	1.5	0.7	0.4	0.4	0.2	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.1	-0.0	1.5	-0.6	-0.5	-0.5	-0.2	-0.8
Back pain experienced in last month	0.9	1.3	6.5	1.4	0.3	-2.5	0.9	0.1	-0.3	0.3
Mineral and other dietary supplements	0.8	1.1	3.0	1.7	1.0	-1.0	0.8	-0.7	-1.2	-0.2
Breast cancer (self-reported)	0.5	0.5	1.8	-0.5	-1.3	1.2	0.3	-0.2	0.3	0.0
Asthma (self-reported)	6.4	12.8	26.2	0.5	-0.2	-4.3	-4.0	-4.7	-2.6	-5.1
Osteoporosis (self-reported)	1.0	1.2	3.4	-0.7	-1.9	0.3	1.0	1.2	1.0	1.0
Osteoarthritis (self-reported)	1.9	2.4	5.6	2.0	-0.4	-2.4	-0.7	-1.7	-0.6	-1.8
Medication: Aspirin	0.5	0.7	1.7	0.2	1.3	-1.0	-1.3	-0.1	0.1	-0.6
Medication: Gliclazide	0.5	0.6	1.2	0.7	0.3	-1.0	-0.1	-1.1	-0.8	-0.9
Illnesses of father: None of the above (group 1)	1.1	1.3	8.1	0.7	0.1	-2.8	0.6	0.5	-0.2	0.4
Smoking status: Current	1.0	1.5	4.3	1.8	0.6	-0.2	-0.2	-1.2	-2.1	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	7.0	-1.5	2.6	0.1	0.5	1.7	1.6	2.4
Whole body water mass	0.3	1.6	4.8	2.2	1.0	-1.9	0.4	-0.1	-1.2	0.5
Leg predicted mass (right)	0.3	1.4	5.3	2.3	0.9	-1.6	0.3	-0.0	-1.0	0.3
Arm fat mass (left)	0.3	1.2	3.0	1.7	-0.4	-1.3	-0.9	-1.1	-0.8	-0.8
Number of self-reported non-cancer illnesses	0.6	1.1	2.9	-0.2	0.7	-1.4	-1.7	-0.6	0.5	-1.2
Average weekly champagne plus white wine intake	1.1	1.5	2.9	0.2	-1.7	1.4	-1.4	-0.3	-1.6	-1.1
Miserableness	0.2	0.3	0.9	0.3	-0.3	0.2	-0.7	0.9	-0.0	0.5
Guilty feelings	0.2	0.3	0.8	-0.7	0.4	0.4	0.1	0.9	0.5	0.4
Wears glasses or contact lenses	0.5	0.6	1.7	0.7	-0.3	-1.1	0.0	-1.3	-0.8	-0.3
Ever taken oral contraceptive pill	0.5	0.6	1.4	-1.0	-0.6	0.8	-1.2	0.4	-0.1	-0.8
Hearing aid user	1.0	1.1	2.8	-1.4	-1.7	1.2	-0.8	-0.1	0.8	-0.5
Mother’s age at death	0.4	0.5	2.2	-0.5	1.5	-0.7	-0.2	0.3	-0.2	-0.4
Financial situation satisfaction	1.5	1.8	4.0	1.0	0.6	-1.8	-0.1	-1.4	-2.0	-1.5
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.9	-0.9	-0.6	1.7	0.7	0.5	0.8	1.2
Commuting to job workplace: Public transport	0.4	0.5	1.5	0.2	-0.6	0.1	1.2	0.2	-0.5	1.2
Eye problems/disorders: Glaucoma	0.3	0.4	1.0	-0.1	-0.6	-0.1	-0.0	-1.0	-0.6	-1.0
Medication: Blood pressure	0.2	0.4	1.5	0.5	-1.2	-1.0	0.4	0.2	0.2	-0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.0	0.4	0.6	-1.0	-0.1	0.2	0.5	-0.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.0	-1.4	0.7	1.1	-1.3	0.1	0.1	-0.3
High cholesterol (Self-reported)	0.2	0.4	1.1	-1.0	0.1	0.1	-0.2	0.6	0.9	0.6
Medication: Bendroflumethiazide	0.4	0.6	1.6	-0.4	-0.6	-1.1	-1.3	-0.3	-0.2	-0.8
Medication: Paracetamol	0.3	0.4	1.0	-0.8	-0.2	-0.2	0.7	0.4	1.0	0.8
Medication: Lisinopril	1.5	1.9	6.9	0.5	-2.6	1.4	-0.5	1.6	0.2	1.2
Medication: Atorvastatin	0.4	0.5	1.6	0.5	1.0	-1.3	-0.1	-0.9	0.1	-0.3
Illnesses of father: High blood pressure	0.5	0.6	2.4	0.1	-0.0	1.6	0.7	0.5	0.6	1.0
Alcohol drinker status: Never	1.0	1.2	3.7	1.4	-1.9	-0.3	0.9	-0.0	-0.8	1.0
Ever smoked	0.7	1.2	3.5	0.6	1.2	-1.5	-0.4	-0.7	-1.9	-0.5
Basal metabolic rate	0.3	1.6	5.6	2.4	0.9	-1.8	0.2	-0.3	-1.2	0.2
Leg fat percentage (left)	0.5	1.7	2.9	1.5	-0.4	-0.8	-1.7	-1.6	-1.5	-1.2
Arm fat-free mass (left)	0.4	2.0	6.1	2.5	1.0	-2.0	-0.1	-0.6	-1.6	0.0
Number of operations (self-reported)	1.3	2.0	4.1	1.2	-1.0	-0.1	-1.9	-2.0	0.2	-2.0
Average weekly beer plus cider intake	0.9	1.3	7.1	-2.7	0.4	0.9	0.0	0.7	0.2	0.6
Irritability	0.5	0.9	3.3	0.6	-0.2	-1.0	0.8	0.6	1.8	0.6
Risk taking	0.9	1.4	3.7	0.9	-0.8	-0.2	-1.6	-0.5	-1.9	-1.3
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.4	0.1	-0.7	1.2	-1.0	0.6	0.8	0.4
Fractured/broken bones in last 5 years	1.1	1.4	5.2	1.7	0.6	-0.4	2.3	-0.1	0.8	1.0
Age started oral contraceptive pill	2.2	2.8	7.7	-2.3	-1.9	0.2	-2.8	-0.4	-1.3	-0.9
Diastolic blood pressure, automated reading	0.3	1.0	3.8	-0.9	-0.0	0.7	-1.9	-0.5	-0.5	-1.1
Ever depressed for a whole week	0.3	0.4	2.1	1.4	0.2	-0.3	0.8	-0.3	-0.1	-0.1
Unable to work because of sickness or disability	0.4	0.5	1.3	-0.2	1.2	-0.6	0.2	-0.8	-0.8	-0.6
Commuting to job workplace: Cycle	0.4	0.5	1.0	0.5	1.0	-0.5	0.5	-1.0	-0.9	-0.4
Myopia	0.5	0.7	1.6	-0.4	-0.2	-0.0	1.3	0.8	1.2	1.0
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.3	0.3	0.1	1.1	1.8	-0.0	0.7	0.7
Cholesterol lowering medication	0.2	0.3	1.1	-0.4	0.8	0.4	-1.0	0.4	-0.1	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	4.5	-0.9	-0.6	-0.3	1.5	2.1	1.6	1.9
Pain experienced in last month	2.7	4.6	8.9	-1.6	-1.0	1.9	1.8	2.7	3.0	2.3
Supplements: Calcium	1.6	1.8	4.7	-0.7	0.8	1.7	0.3	2.2	1.7	0.9
Basal cell carcinoma (self-reported)	0.8	0.9	3.6	-0.9	-0.7	1.9	-0.1	0.6	0.9	0.5
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.5	0.2	0.8	-0.9	-1.1	-1.0	0.3	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.3	1.5	-0.9	-0.4	-0.5	-1.1	-0.3	-1.1
Heart disease (siblings)	0.7	0.8	1.8	-1.3	1.3	0.5	-1.2	-0.3	0.9	-0.0
Alcohol drinker status: Previous	0.7	0.8	3.2	0.3	1.8	-1.5	-0.4	-0.4	0.2	-0.1
Pack years of smoking	0.5	0.7	3.1	-0.4	-1.8	-0.2	-0.8	-0.5	-0.3	-0.6
Impedance of whole body	0.3	1.5	6.9	-1.1	-0.6	2.6	0.2	0.3	1.4	-0.2
Leg fat mass (left)	0.4	1.5	3.8	2.0	0.1	-1.2	-1.0	-1.3	-1.4	-0.8
Arm predicted mass (left)	0.4	2.0	5.5	2.4	1.1	-2.2	0.0	-0.5	-1.4	0.2