Hub : Genes

FPR3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.6250 0.0660 5.8e-10 0.584 NA 0.516 NA 0.576 2.5e-31 NA 2.8e-26 NA 9.7e-31
2 GTEx Whole Blood 0.1290 0.0530 2.6e-03 0.014 NA 0.000 NA 0.008 1.8e-02 NA 3.4e-01 NA 5.4e-02
3 YFS Blood 0.1472 0.0225 0.0e+00 0.048 0.078 0.100 0.105 0.102 2.3e-15 3.9e-24 8.5e-31 2.2e-32 1.1e-31
4 TCGA Lung Adenocarcinoma 0.0505 0.0262 3.3e-03 0.013 0.008 0.013 NA 0.018 9.1e-03 3.2e-02 9.9e-03 NA 2.7e-03
5 TCGA Lung Squamous Cell Carcinoma 0.0519 0.0247 3.6e-03 0.031 0.023 0.013 NA 0.023 1.7e-04 1.0e-03 1.2e-02 NA 1.1e-03
6 TCGA Pancreatic Adenocarcinoma 0.1750 0.0730 1.6e-03 0.096 0.032 0.019 NA 0.066 8.2e-05 1.7e-02 5.3e-02 NA 9.7e-04
7 TCGA Stomach Adenocarcinoma 0.0690 0.0350 8.3e-03 -0.003 0.003 -0.003 NA -0.003 7.5e-01 1.9e-01 6.0e-01 NA 6.2e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.4 0.7 2.4 0.2 -0.8 -1.5 -0.0 -0.8 -1.1 -0.4
Bipolar Disorder or Schizophrenia 0.4 0.9 4.2 0.5 -0.0 -2.1 1.0 -0.1 0.5 0.7
Depressed Affect (Nagel 2018) 0.4 0.9 1.8 1.0 -0.8 -1.4 0.7 1.1 0.3 1.2
Depression (Nagel 2018) 0.3 0.5 1.3 -0.8 -0.6 -0.8 -1.1 0.2 0.1 -0.7
Intelligence (Savage-Jansen 2018) 0.5 1.7 4.3 -0.1 0.8 1.6 -2.1 -0.7 -1.8 -0.8
Neuroticism (Nagel 2018) 0.3 0.7 3.9 0.3 -0.9 -2.0 0.1 0.1 0.5 0.3
Schizophrenia (2018) 0.6 1.2 2.2 0.4 0.6 -1.4 1.3 0.5 1.5 1.2
Schizophrenia vs Biploar Disorder 0.4 0.6 1.4 0.7 -0.1 0.4 1.2 0.6 1.2 0.4
Worry (Nagel 2018) 0.9 1.9 3.9 -1.3 -0.3 -1.1 0.8 1.6 1.8 2.0
Alzheimer’s Disease (in mother) 1.1 1.3 2.1 0.8 -1.1 1.4 0.6 1.2 1.2 1.4
Alzheimer’s Disease (in father) 0.2 0.2 0.7 0.0 -0.2 0.0 0.8 -0.3 -0.8 -0.2
Alzheimer’s Disease (including proxy) 1.0 1.5 5.1 0.2 -2.0 2.2 0.5 0.7 0.6 0.7
Crohns Disease (2017) 0.2 0.5 2.0 1.4 -0.1 0.1 0.6 -0.8 0.1 -0.4
Irritable Bowel Disease (IBD) 0.5 1.2 3.6 0.4 0.5 -1.0 -0.9 -1.4 -0.9 -1.9
Ulcerative Colitis (UC) 1.1 2.0 4.8 -0.5 0.8 -1.8 -1.6 -1.1 -1.2 -2.2
Major Depression (MDD) 0.7 0.9 2.5 1.6 -0.6 1.1 0.3 0.7 0.1 1.1
Reaction Time 0.4 0.8 1.5 -1.0 -1.2 0.7 0.0 1.0 1.1 0.4
Verbal and Numeric Reasoning (VNR) 0.4 1.0 3.6 1.1 1.9 0.7 -0.9 -0.4 -0.9 0.0
Breast Cancer 0.8 1.9 4.8 1.3 -0.1 0.5 2.2 1.5 1.2 1.7
Ovarian Cancer 1.2 1.6 3.4 1.4 -0.3 -1.8 -0.2 -1.4 -1.3 -1.4
Prostate Cancer 1.1 1.6 4.0 2.0 -1.3 -0.8 -0.3 -1.9 -0.2 -1.2
Age at First Birth 1.0 1.4 3.0 1.1 -1.7 0.3 1.5 0.9 -0.5 1.4
Bipolar Disorder (2011) 0.5 0.4 1.6 -0.3 0.0 1.2 -0.6 -0.5 -0.6 -0.6
Body Mass Index (BMI) (2010) 1.1 1.5 2.7 -1.5 -1.6 0.5 1.3 1.0 1.5 0.6
Coronary Artery Disease (CAD) 0.2 0.2 0.7 -0.0 -0.4 0.4 -0.1 0.3 0.8 0.5
Crohns Disease (2012) 0.5 0.8 1.6 1.1 -0.9 -0.3 1.3 -1.2 0.3 -0.3
Mean Putamen Volume 0.8 0.9 2.8 0.9 1.0 -0.5 1.7 -0.2 0.9 0.7
Fasting Glucose 1.2 1.4 3.4 -1.1 -1.4 0.9 -1.9 -0.6 -0.7 -1.3
HbA1C 0.4 0.4 1.2 -0.1 -1.1 0.9 0.9 -0.1 -0.2 -0.1
HDL Cholesterol 8.8 14.6 27.6 3.4 -1.6 -1.6 -3.4 -4.8 -5.2 -4.8
LDL Cholesterol 1.1 1.7 6.6 0.6 0.4 0.7 -1.0 -1.2 -2.6 -1.3
Lupus 0.3 0.5 1.6 -1.3 -0.3 0.6 -0.8 0.8 0.3 0.1
Neuroticism (2016) 0.6 0.9 2.5 0.7 -1.4 -1.6 -0.5 -0.3 0.1 -0.9
Primary Biliary Cirrhosis 2.6 3.6 5.6 1.4 -1.7 -2.4 -1.4 -1.8 -2.1 -2.3
Rheumatoid Arthritis 0.6 0.9 4.0 -0.3 2.0 -1.1 0.1 -0.8 0.3 -0.3
Schizophrenia (2014) 0.3 0.7 3.4 0.2 -0.7 -1.9 0.7 -0.3 0.3 0.0
Triglycerides 0.4 0.7 2.3 -1.5 0.3 0.6 0.2 1.0 0.7 0.9
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.6 -0.8 1.2 -0.2 -0.2 0.2 1.3 0.7
Ulcerative Colitis 0.7 1.0 1.9 -1.4 1.0 -0.7 -0.9 -0.9 -0.3 -1.2
Blood Eosinophil Count 4.4 34.2 59.9 -0.3 -0.2 -6.2 -7.7 -7.4 -5.3 -7.7
Blood Platelet Count 0.3 3.4 16.6 -4.1 1.6 -1.8 0.2 0.3 0.8 0.4
Blood Red Count 0.2 2.0 5.4 2.3 -0.2 -1.8 0.7 -1.9 -0.8 -1.0
Blood White Count 0.4 2.8 16.0 -0.4 1.4 -4.0 0.3 -0.7 -0.7 -0.4
Heel T-Score 1.9 14.9 26.8 -2.7 -1.1 4.3 2.9 4.5 4.8 5.2
BMI 0.2 1.0 2.1 1.4 -1.1 -1.4 -0.7 -1.2 -0.3 -0.1
Height 0.2 3.5 11.0 1.5 3.3 -1.6 -0.8 -2.0 -1.1 -1.7
Waist Hip Ratio (WHR) 0.3 1.4 4.3 -0.3 -0.6 -2.1 -0.4 -1.7 0.1 -1.5
Systolic Blood Pressure 0.1 0.6 2.0 0.9 0.2 -1.1 0.2 0.2 1.4 -0.0
Smoking Status 0.7 1.8 8.9 0.8 3.0 -1.3 0.9 0.3 -0.5 0.2
Allergy or Eczema 2.2 5.8 13.1 -1.1 -0.2 -1.2 -3.6 -3.3 -1.3 -3.5
Cardiovascular Disease 0.2 0.5 1.3 -1.1 0.9 -0.7 -0.6 0.4 0.4 0.6
Hypothyroidism (self reported) 0.7 1.6 3.3 -0.4 1.6 0.0 1.8 1.4 1.5 1.1
Respiratory disease 3.2 7.0 13.4 -0.7 -0.4 -3.3 -3.3 -3.1 -2.0 -3.7
Type 2 Diabetes (T2D) (2018) 0.8 1.5 3.1 1.8 1.3 -1.5 -0.1 -1.5 -0.3 -1.1
Lung FEV1/FVC ratio 3.0 15.0 61.3 -7.8 -0.0 4.0 -1.6 3.0 3.9 1.4
Lung FVC 0.9 4.8 13.7 -0.4 2.6 0.5 2.3 1.7 2.1 3.7
Neuroticism 0.2 0.4 1.2 0.6 -0.8 -1.1 -0.0 0.1 0.6 0.3
Chronotype (morning person) 0.2 0.5 2.3 -1.5 0.2 1.0 -0.3 0.1 0.2 0.5
Hair Pigment 0.0 0.4 1.1 -0.5 0.1 1.1 0.0 -0.9 0.3 -0.5
Tanning 0.0 0.3 0.8 -0.1 -0.1 -0.8 -0.3 -0.9 -0.7 -0.3
Hand grip strength (left) 0.4 1.0 2.7 0.6 1.6 -1.3 0.9 0.7 -0.6 0.8
Number of treatments/medications taken 0.2 0.4 1.6 -0.1 -0.6 -1.3 0.1 0.5 0.9 0.2
Average weekly spirits intake 1.3 1.6 5.0 2.2 0.7 -2.1 -0.5 -0.7 -0.4 -0.9
Sensitivity / hurt feelings 1.4 2.4 5.7 0.2 0.7 -2.0 -1.3 -2.4 -0.1 -2.1
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.0 -0.3 0.5 -0.3 0.5 0.8 1.0 0.1
Hearing difficulty/problems: Yes 0.4 0.6 1.8 0.5 1.4 -0.4 1.1 -0.6 -0.0 -0.1
Relative age of first facial hair 0.7 1.5 4.7 0.3 -0.8 -0.5 -1.1 -2.2 -0.7 -1.7
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.9 -0.8 0.3 0.0 0.8 1.7 1.4 0.6
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.4 -0.7 -0.4 0.3 0.5 0.2 0.4 0.1
Ever had hysterectomy (womb removed) 0.3 0.3 1.4 -1.2 -0.4 0.4 -0.3 -0.1 0.6 0.4
Systolic blood pressure, automated reading 0.3 1.0 3.0 0.7 0.6 -0.4 -1.7 -0.7 0.3 -1.4
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.0 0.1 1.4 -1.3 -1.1 -0.7 -0.7 -0.6
Angina 0.6 0.7 1.8 -0.3 -1.2 -0.3 1.4 0.9 -0.1 1.0
Medication for hormone replacement therapy 0.5 0.6 2.4 0.5 -1.6 0.1 -0.2 -0.5 -0.3 -1.0
Vitamin and mineral supplements 1.2 1.6 3.0 1.4 1.1 -0.0 -1.0 -1.5 -1.7 -1.2
Supplements: Zinc 0.6 0.7 2.7 -1.7 -0.2 -1.1 -0.3 0.8 0.0 0.4
Medication: Co-codamol 0.4 0.4 1.9 -1.4 0.3 -0.5 -0.4 -0.2 0.7 -0.3
Medication: Metformin 1.6 2.3 7.9 2.8 -0.2 -1.4 -0.2 -1.8 -0.9 -1.5
Diabetes (father) 0.9 1.1 3.8 1.5 0.1 -0.6 0.5 -0.5 2.0 -0.6
Diabetes (mother) 0.5 0.6 1.4 -0.0 0.2 -1.0 0.6 -1.2 -1.1 -0.6
Severe depression (siblings) 0.8 0.9 2.5 -1.2 -0.3 -0.1 0.1 1.6 1.3 0.8
Pack years adult smoking proportion 0.3 0.5 3.0 -0.2 -1.7 -0.1 -0.5 -0.2 -0.2 -0.2
Impedance of leg (right) 0.3 1.3 4.8 -1.4 -0.3 2.2 0.5 0.4 1.4 0.2
Leg fat-free mass (left) 0.3 1.6 5.3 2.3 1.0 -1.9 0.1 -0.4 -1.2 0.1
Trunk fat percentage 0.3 1.0 2.7 1.6 -0.7 -0.4 -0.9 -1.3 -0.2 -1.2
Hand grip strength (right) 0.3 0.9 2.0 1.3 0.5 -0.8 1.2 0.4 -1.4 0.3
Townsend deprivation index at recruitment 0.8 1.2 2.8 0.9 1.7 -1.6 -0.1 -0.8 -0.7 -1.0
Current tobacco smoking 1.0 1.6 4.8 2.0 0.1 -0.4 0.2 -1.2 -2.2 -1.1
Average weekly fortified wine intake 0.3 0.4 1.3 -0.6 0.1 0.6 -1.2 -0.5 -0.2 -0.2
Maternal smoking around birth 0.2 0.3 1.5 -1.2 0.1 0.6 -0.4 0.0 0.1 -0.2
Fed-up feelings 0.2 0.3 0.8 0.1 -0.2 -0.5 0.5 0.9 0.6 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.1 -0.8 -0.5 -0.7 -1.0 0.0 -0.2 -1.1
Relative age voice broke 0.4 0.7 1.8 1.0 -0.5 -1.3 0.0 -0.6 1.0 -0.5
Taking other prescription medications 0.9 1.4 4.8 1.5 0.1 -2.2 -0.2 -1.1 0.6 -1.0
Age when periods started (menarche) 1.0 2.3 5.6 0.4 1.0 0.8 -1.9 -1.9 -1.3 -2.4
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 2.0 0.4 -1.2 0.5 1.4 -0.2 0.6 0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.6 7.0 -1.1 0.2 1.1 2.0 1.2 1.8 2.6
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.7 -0.6 -0.3 -0.7 0.8 0.6 0.3 0.7
Qualifications: CSEs or equivalent 0.5 0.7 1.7 1.3 1.3 -0.5 0.4 -0.6 -0.6 -0.3
Serious illness, injury or assault to yourself 0.3 0.4 1.8 0.4 0.5 -1.4 0.2 -0.6 0.1 -0.5
High blood pressure 0.3 0.9 3.0 0.0 0.2 -1.6 -1.7 -0.1 -0.2 -0.8
Hayfever, allergic rhinitis or eczema 2.3 4.9 9.9 -0.7 -0.8 -1.9 -3.1 -2.8 -1.5 -3.1
Multivitamins +/- minerals 1.7 2.1 4.6 -1.0 -0.2 0.5 1.5 2.1 2.0 1.7
Stomach or abdominal pain in last month 0.1 0.1 0.4 -0.0 -0.1 0.3 -0.2 0.6 -0.3 0.3
Supplements: Glucosamine 0.2 0.3 0.7 0.8 0.0 -0.1 -0.8 -0.1 -0.4 -0.6
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.7 -0.1 0.5 -1.3 0.5 -0.7 -0.1 -0.3
Medication: Atenolol 0.3 0.4 0.7 -0.4 -0.8 -0.8 -0.6 0.6 0.6 -0.4
Medication: Levothyroxine sodium 1.0 1.7 3.5 0.1 0.9 0.7 1.9 1.7 1.2 1.7
Sitting height 0.5 3.9 10.2 0.1 1.6 0.5 2.3 2.9 0.9 3.2
Chronic bronchitis/emphysema (father) 1.3 1.5 6.8 0.4 -2.6 -1.0 0.8 -0.8 -1.1 -0.4
High blood pressure (mother) 0.6 0.9 3.3 0.7 0.7 -0.3 0.8 0.2 1.8 1.0
Body mass index (BMI) 0.5 2.2 5.0 2.2 -0.2 -2.2 -1.0 -1.5 -1.2 -0.9
Impedance of leg (left) 0.3 1.6 6.2 -1.3 -0.7 2.5 0.6 0.8 1.4 0.3
Leg predicted mass (left) 0.3 1.8 5.8 2.4 1.1 -1.9 0.1 -0.4 -1.2 0.0
Trunk fat mass 0.2 1.1 3.4 1.8 -0.4 -0.7 -0.8 -1.2 -0.8 -0.9
Waist circumference 0.6 2.3 5.4 2.1 -0.2 -2.3 -1.1 -1.8 -1.0 -1.2
Number of incorrect matches in round 0.8 1.4 4.7 -2.2 1.5 -1.1 0.0 1.0 0.4 0.7
Past tobacco smoking 0.9 1.7 5.2 -0.8 -2.3 2.2 0.4 0.4 0.8 0.7
Alcohol usually taken with meals 0.5 0.8 2.1 -1.2 0.3 -0.0 -1.4 -0.8 -0.9 -0.9
Nervous feelings 0.7 1.3 3.5 -0.6 -0.5 -1.0 1.2 0.8 1.9 1.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.9 -0.2 0.6 -0.9 -0.9 -0.3 0.1 -0.9
Hearing difficulty/problems with background noise 0.2 0.4 0.9 0.9 0.5 -0.1 0.7 -0.6 -0.5 -0.8
Hair/balding pattern: Pattern 2 0.3 0.4 1.0 1.0 -1.0 -0.4 0.0 0.3 0.0 -0.6
Had menopause 0.7 0.8 1.7 0.3 0.2 -0.7 -1.1 -1.1 -1.3 -0.9
Had other major operations 0.5 0.6 1.6 -0.1 -0.4 0.7 0.0 0.8 1.2 1.3
Forced vital capacity (FVC) 0.5 2.1 6.2 1.1 2.5 0.1 1.3 0.6 0.7 2.1
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.4 4.9 -1.4 1.3 0.3 1.7 0.9 2.2 2.2
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 1.2 1.1 0.3 -0.4 0.1 -0.4 -0.4 0.2
Qualifications: None of the above 0.4 0.8 2.2 -1.2 0.0 -1.1 0.3 -1.5 0.0 -0.9
Financial difficulties in last 2 years 0.5 0.7 2.5 1.6 -0.0 -1.1 -0.4 -0.7 -0.5 -0.6
Mouth/teeth dental problems 0.6 0.9 1.7 -1.1 -0.8 0.6 0.6 0.9 -1.3 1.1
Heart attack 0.6 0.8 1.6 0.4 0.5 -1.1 -1.0 -1.0 0.2 -1.3
Allergy 4.6 10.7 22.4 -0.2 1.7 3.4 4.2 4.1 1.9 4.7
Pain all over the body in last month 3.2 3.4 6.6 0.2 0.8 -1.9 -2.3 -1.8 -2.1 -2.6
Diabetes (self-reported) 1.0 1.5 3.3 1.8 0.8 -1.7 -0.6 -1.5 -0.3 -1.0
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 4.9 0.9 -0.0 -0.4 -2.2 -2.0 -0.8 -1.9
Medication: Ramipril 0.3 0.4 1.3 -0.5 0.1 0.4 -0.9 0.4 1.1 -0.0
Medication: Simvastatin 1.0 1.4 3.2 -1.4 -0.5 1.6 -0.7 1.8 0.9 0.8
Fluid intelligence score 0.9 1.9 4.4 1.7 2.1 0.5 -1.4 -1.0 -1.5 -0.8
Illnesses of siblings 0.8 1.1 3.2 1.8 -1.2 -0.5 1.3 0.1 -1.1 0.3
Neuroticism score 0.2 0.5 1.6 -0.0 -0.1 -1.2 0.5 0.3 1.0 0.7
Weight 0.4 2.0 6.5 2.5 0.5 -1.9 -0.1 -1.1 -1.4 -0.4
Impedance of arm (right) 0.2 1.1 4.0 -1.0 -0.4 2.0 -0.1 0.0 1.6 -0.5
Arm fat percentage (right) 0.3 1.0 2.7 1.6 -0.7 -0.8 -1.0 -1.3 -0.2 -0.9
Trunk fat-free mass 0.3 1.6 4.5 2.1 0.9 -1.9 0.4 -0.1 -1.5 0.5
Hip circumference 0.4 1.7 7.8 2.8 0.5 -1.3 -0.7 -0.5 -1.1 -0.1
Time employed in main current job 0.5 0.6 1.4 -0.1 -0.2 0.7 1.2 1.0 0.5 0.9
Alcohol intake versus 10 years previously 0.2 0.2 0.6 -0.2 -0.0 0.8 -0.3 0.6 0.6 0.5
Father’s age at death 0.2 0.3 1.9 -0.2 1.4 -0.2 0.5 -0.1 0.0 -0.4
Worrier / anxious feelings 0.4 0.7 1.8 -0.2 -1.2 -1.4 -0.4 0.4 1.0 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.1 -0.1 1.1 -0.2 -0.8 -0.2 -0.7 -0.3
Falls in the last year 1.0 1.3 2.9 0.3 -1.1 0.0 -1.2 -1.4 -1.3 -1.7
Hair/balding pattern: Pattern 3 0.3 0.4 1.7 -1.3 -0.5 0.6 0.1 0.8 -0.1 0.4
Number of live births 0.3 0.4 1.7 0.5 -0.4 -1.3 0.1 -0.6 -0.0 -0.5
Forced expiratory volume in 1-second (FEV1) 1.1 3.6 8.2 -0.7 2.4 1.0 1.4 1.9 2.0 2.9
Pulse rate 0.2 0.3 1.0 -1.0 -0.6 0.7 -0.7 -0.3 0.1 -0.1
Happiness 4.0 4.9 8.8 1.2 1.0 -1.4 -2.6 -2.7 -2.8 -3.0
Noisy workplace 0.7 0.9 1.6 1.3 0.6 -1.0 -0.9 -1.0 -0.7 -1.0
Qualifications: A levels/AS levels or equivalent 0.5 1.1 3.7 -0.8 1.9 1.4 -0.8 0.5 0.5 0.4
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 4.1 1.0 2.0 0.0 0.7 0.7 1.5 1.1
Mouth/teeth dental problems: Dentures 0.1 0.2 0.4 0.7 -0.3 -0.4 -0.5 0.1 0.5 -0.2
Asthma 5.9 11.6 24.3 0.6 -0.1 -4.0 -3.9 -4.5 -2.2 -4.9
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.7 7.5 -0.8 -0.4 0.4 1.6 2.4 1.3 2.7
Medication: Cholesterol lowering 0.5 0.7 2.7 -0.2 -0.5 0.3 -0.0 1.1 1.6 0.9
Depression (self-reported) 0.6 0.7 1.5 0.7 1.2 1.0 0.7 0.4 0.4 0.9
Medication: Lansoprazole 0.6 0.7 2.5 -0.3 0.0 -0.6 -0.5 -1.2 -0.1 -1.6
Prospective memory result 1.9 2.4 6.3 -1.3 -0.3 -0.7 1.5 2.0 2.5 1.4
Lung cancer (father) 1.2 1.4 4.7 1.7 -0.6 -2.2 0.5 -0.9 -0.5 -0.5
Illnesses of mother 3.0 3.7 9.6 -1.1 -1.5 -1.2 -2.2 -1.5 -3.1 -2.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.9 6.0 15.3 -0.8 3.9 0.4 1.9 2.4 2.1 3.5
Pulse wave Arterial Stiffness index 0.9 1.0 2.3 1.4 0.4 -1.5 -0.9 -0.3 -0.9 -1.0
Impedance of arm (left) 0.3 1.5 6.3 -1.3 -0.3 2.5 0.2 0.1 1.5 -0.5
Arm fat mass (right) 0.4 1.5 4.4 2.1 -0.3 -1.5 -0.8 -1.4 -0.8 -0.9
Trunk predicted mass 0.3 1.5 4.4 2.1 0.8 -1.8 0.4 -0.0 -1.4 0.5
Standing height 0.1 1.1 3.1 1.2 1.4 0.1 1.8 0.5 -0.6 0.9
Length of working week for main job 0.6 0.7 1.3 0.6 -0.3 -0.2 -1.0 -1.1 -0.9 -1.1
Exposure to tobacco smoke at home 0.7 0.8 1.8 1.4 0.4 -0.5 1.3 0.6 0.8 0.8
Breastfed as a baby 1.6 2.0 3.4 0.2 -1.8 -0.7 -1.5 -1.8 -1.4 -1.6
Tense / ‘highly strung’ 2.3 3.8 11.6 -0.9 1.2 0.1 2.1 1.8 3.4 2.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.1 1.0 1.1 -1.0 0.5 0.4 0.0 0.9
Hair/balding pattern: Pattern 4 0.2 0.6 1.3 -0.4 1.2 0.2 0.8 0.9 0.5 0.9
Birth weight of first child 1.1 2.0 5.4 -2.3 -0.2 0.8 -1.8 -1.1 -1.6 -1.0
Peak expiratory flow (PEF) 0.8 1.8 3.7 -0.3 1.9 -0.9 0.9 1.2 1.4 1.9
Pulse wave reflection index 0.8 0.9 2.4 0.8 1.2 -1.6 -0.2 -0.4 -1.3 -0.4
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.5 0.7 0.6 0.5 0.2 0.2 -0.4 -0.0
Loud music exposure frequency 1.2 1.3 4.3 2.1 0.0 -1.1 1.8 0.4 -0.3 0.4
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 3.6 0.9 0.1 1.6 0.3 1.9 1.4 1.8
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 3.1 -0.8 1.0 1.8 0.1 0.5 1.5 0.4
Blood clot in the leg (DVT) 0.9 1.1 2.4 1.5 -1.5 -0.4 -0.4 -1.2 -0.4 -1.2
Medication: Paracetamol 0.2 0.3 1.2 -0.9 -0.4 -0.2 0.1 -0.1 1.1 0.2
Headache pain in last month 0.2 0.3 0.7 0.3 0.3 0.5 -0.7 -0.8 -0.3 -0.5
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 2.4 0.6 -0.1 0.1 1.1 -1.2 -1.6 -0.9
Glaucoma (self-reported) 0.2 0.2 0.8 -0.3 -0.9 -0.5 0.3 -0.0 0.5 -0.1
Gout (self-reported) 0.4 0.6 1.8 0.2 -0.8 -0.8 -1.3 -0.0 -0.7 -0.7
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 4.2 0.2 1.1 0.3 2.0 1.8 1.4 1.3
Medication: Amlodipine 0.5 0.7 2.9 0.1 1.1 -0.5 0.4 -0.1 1.7 0.2
Medication: Ventolin 100micrograms inhaler 3.9 5.0 10.0 1.0 -0.3 -3.0 -1.9 -3.2 -1.3 -3.1
Birth weight 1.1 2.4 12.9 -3.6 -0.8 1.0 -0.9 0.9 0.5 0.2
Chronic bronchitis/emphysema (mother) 1.3 1.5 5.2 -0.7 0.3 2.3 -1.2 -0.3 1.6 -0.8
High blood pressure (siblings) 0.7 0.9 3.0 -1.7 0.4 0.4 -1.0 0.5 1.5 0.1
Forced vital capacity (FVC), Best measure 1.3 4.9 17.0 1.1 4.1 -0.8 1.9 1.4 0.9 2.9
Body fat percentage 0.3 1.1 2.2 1.3 -0.5 -0.4 -1.3 -1.5 -0.7 -1.3
Leg fat percentage (right) 0.6 2.0 3.3 1.4 -0.0 -0.9 -1.8 -1.8 -1.6 -1.5
Arm fat-free mass (right) 0.4 1.8 5.2 2.3 0.9 -2.0 0.3 -0.1 -1.6 0.3
Exposure to tobacco smoke outside home 0.9 1.2 2.3 -0.4 0.3 -0.9 -1.5 -1.4 -1.4 -1.2
Comparative body size at age 10 0.1 0.3 1.2 -1.1 -0.3 -0.5 -0.1 0.4 -0.5 0.6
Number of full brothers 3.0 3.8 9.0 -0.2 -1.5 -1.3 -1.5 -1.9 -3.0 -2.8
Worry too long after embarrassment 0.4 0.7 2.9 1.1 0.3 -1.7 0.6 -0.3 0.3 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.4 0.0 -0.4 0.7 0.4 0.2 0.1 0.2
Wheeze or whistling in the chest in last year 2.4 4.3 9.0 1.7 -1.1 -1.7 -2.2 -2.6 -1.4 -3.0
Number of children fathered 1.1 1.2 3.3 -0.1 -1.4 -0.6 -1.8 -0.6 -0.7 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 1.0 -0.3 -0.5 0.2 -0.2 0.2 -0.3 1.0
Age at first live birth 0.7 1.2 4.2 -0.6 2.1 0.8 0.9 0.5 0.6 1.4
Pulse wave peak to peak time 0.9 1.0 2.5 -1.3 -0.3 1.6 1.0 0.3 0.8 1.0
Health satisfaction 0.7 0.9 3.5 0.0 0.8 0.2 -1.0 -0.6 -1.9 -0.7
Shortness of breath walking on level ground 0.5 0.6 1.6 -0.6 -1.3 0.2 0.5 0.1 1.2 -0.1
Qualifications: College or University degree 0.0 0.1 0.2 0.4 0.3 -0.4 -0.4 -0.0 0.0 -0.1
Eye problems/disorders: None of the above 1.2 1.4 2.3 -0.6 -1.1 1.2 1.2 1.3 1.5 1.2
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.9 0.4 0.5 -0.9 0.0 -0.1 0.4 -0.5
Emphysema/chronic bronchitis 0.5 0.6 1.1 1.0 -0.8 -0.6 -0.7 -0.4 -0.8 -0.9
Medication for pain relief, constipation, heartburn 0.4 0.7 2.3 0.4 0.5 0.2 -0.4 -1.0 -1.5 -0.9
Neck or shoulder pain in last month 0.6 0.9 3.6 1.9 0.2 -0.6 0.3 -0.9 -1.2 -0.4
Medication: Blood pressure 0.3 0.5 2.2 -0.2 -0.3 -0.6 -1.5 0.6 0.8 0.3
Angina (self-reported) 0.5 0.7 1.4 -0.3 -0.8 -0.3 1.2 1.2 0.2 1.1
Migraine (self-reported) 0.4 0.5 1.5 0.0 0.2 -1.2 -0.9 0.3 0.9 -0.0
Medication: Ibuprofen 1.8 2.2 6.1 -1.3 -0.5 0.3 0.9 2.5 0.5 2.5
Medication: Allopurinol 0.7 0.9 1.9 -0.4 -1.0 -0.7 -1.3 -0.6 -1.4 -1.0
Medication: Omeprazole 1.4 1.7 3.9 -0.8 -1.3 0.8 0.9 2.0 0.8 1.9
Medication: Seretide 50 evohaler 2.8 3.2 6.8 0.6 -2.6 -1.2 -1.4 -1.5 -2.3 -2.1
Mean time to correctly identify matches 0.4 0.7 1.4 -0.9 -1.2 -0.1 -1.0 -0.6 0.2 -1.1
Heart disease (mother) 0.5 0.6 1.4 1.2 -0.3 0.5 1.1 0.7 0.3 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.0 5.4 -1.0 0.1 0.6 -0.5 0.4 2.3 0.1
Whole body fat mass 0.4 1.6 3.2 1.8 -0.4 -1.0 -1.2 -1.5 -1.2 -1.3
Leg fat mass (right) 0.4 1.7 3.2 1.8 0.4 -1.1 -1.3 -1.5 -1.5 -1.0
Arm predicted mass (right) 0.4 1.9 5.2 2.3 0.7 -2.1 0.2 -0.4 -1.8 0.1
Pulse rate, automated reading 0.4 1.1 7.2 -2.7 0.2 0.2 -0.1 0.0 0.8 0.2
Alcohol intake frequency. 0.2 0.5 1.7 -0.0 0.6 -1.3 0.2 0.5 0.3 0.9
Comparative height size at age 10 0.1 0.3 0.5 0.7 -0.0 0.4 0.7 0.6 -0.4 0.5
Number of full sisters 1.6 2.0 4.1 0.8 1.4 -1.7 -1.4 -1.6 -0.2 -2.0
Suffer from ‘nerves’ 1.9 3.0 7.1 -2.7 0.3 0.4 1.3 1.4 2.2 2.3
Overall health rating 0.2 0.5 1.5 0.6 0.8 -1.2 -0.6 -0.2 -0.5 -0.7
Chest pain or discomfort 0.5 0.7 1.9 -0.5 -0.8 -0.2 -1.1 -0.2 -1.4 -0.7
Had major operations 1.7 2.0 4.7 0.3 -0.5 -0.7 -1.9 -1.8 -1.2 -2.2
Age at last live birth 1.7 2.5 5.4 -1.2 0.7 0.9 1.9 1.9 1.4 2.3
Family relationship satisfaction 2.4 3.0 7.8 0.1 1.4 -1.0 -2.3 -1.4 -2.8 -1.7
Leg pain on walking 0.3 0.3 1.1 -0.7 0.3 0.4 -0.2 1.1 0.6 0.0
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 3.2 1.2 -0.0 -1.7 -1.8 -0.3 -0.1 -1.3
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.7 1.1 -0.1 0.2 0.3 1.3 0.5 0.3
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 3.3 -0.8 -1.8 0.7 -0.4 -0.5 0.4 -0.5
Medication: Aspirin 0.4 0.5 1.4 -0.3 0.8 -0.6 -1.2 0.3 1.0 -0.4
Supplements: Vitamin C 0.8 0.9 4.3 0.6 0.3 -2.1 1.1 0.1 -0.5 0.6
Knee pain experienced in last month 0.6 1.0 2.7 -0.6 -1.0 -0.9 -1.6 -0.9 -0.9 -0.9
Hypertension (Self-reported) 0.5 1.3 3.9 0.1 0.4 -1.8 -2.0 -0.5 -0.2 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 2.5 -0.5 0.3 -1.0 0.8 1.6 1.4 1.2
Illnesses of father: Heart disease 0.9 1.2 3.1 -1.7 0.3 1.3 -1.8 0.2 0.7 -0.1
Illnesses of siblings: Diabetes 0.6 0.8 1.5 -1.2 0.3 0.7 -0.1 1.1 1.1 1.1
Smoking status: Previous 0.9 1.3 4.9 0.1 2.2 -1.8 0.2 0.4 0.6 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.7 2.4 0.5 1.5 -0.3 1.0 0.6 -0.5 0.9
Whole body fat-free mass 0.3 1.7 5.5 2.3 0.9 -1.9 0.3 -0.0 -1.3 0.4
Leg fat-free mass (right) 0.3 1.5 5.4 2.3 0.8 -1.7 0.3 -0.1 -1.1 0.3
Arm fat percentage (left) 0.2 0.9 1.9 1.4 -0.9 -0.5 -0.9 -1.2 -0.4 -1.0
Average weekly red wine intake 0.4 0.6 1.2 -0.6 1.1 0.6 -1.1 -0.5 -0.2 -0.6
Handedness (chirality/laterality): Left-handed 1.0 1.2 2.3 1.2 1.4 -0.9 0.8 1.5 0.5 0.9
Mood swings 0.3 0.5 1.7 -0.1 -1.3 -0.7 0.0 0.6 0.9 0.7
Loneliness, isolation 1.2 1.7 6.7 1.7 -0.7 -2.6 -0.1 -0.5 -1.0 -0.7
Long-standing illness, disability or infirmity 0.4 0.6 2.1 1.2 0.5 -1.5 -0.1 -0.1 0.5 -0.1
Ever had bowel cancer screening 0.6 0.7 2.5 0.4 0.0 1.1 0.6 0.5 1.6 0.1
Diabetes diagnosed by doctor 1.0 1.7 4.0 2.0 0.4 -1.4 -0.7 -1.7 -0.2 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.7 -0.6 -0.2 0.4 0.5 0.1 0.8 0.2
Friendships satisfaction 3.5 4.3 7.3 1.6 0.2 -1.3 -2.2 -2.7 -2.7 -2.6
Qualifications: nursing, teaching 0.3 0.4 0.9 0.3 0.9 0.2 0.3 0.9 0.8 0.7
Commuting to job workplace: Walk 1.2 1.3 2.6 -0.6 -0.2 -0.1 -1.4 -1.6 -1.6 -1.3
Eye problems/disorders: Cataract 0.4 0.4 1.4 0.7 1.0 -0.0 -0.1 -0.2 -1.2 0.0
Mouth/teeth dental problems: Mouth ulcers 4.1 6.5 15.9 2.3 1.2 -2.4 -1.7 -4.0 -1.2 -3.6
Medication for cholesterol 0.3 0.5 2.2 0.1 1.5 0.7 0.4 0.4 0.2 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 2.1 -0.0 1.5 -0.6 -0.5 -0.5 -0.2 -0.8
Back pain experienced in last month 0.9 1.3 6.5 1.4 0.3 -2.5 0.9 0.1 -0.3 0.3
Mineral and other dietary supplements 0.8 1.1 3.0 1.7 1.0 -1.0 0.8 -0.7 -1.2 -0.2
Breast cancer (self-reported) 0.5 0.5 1.8 -0.5 -1.3 1.2 0.3 -0.2 0.3 0.0
Asthma (self-reported) 6.4 12.8 26.2 0.5 -0.2 -4.3 -4.0 -4.7 -2.6 -5.1
Osteoporosis (self-reported) 1.0 1.2 3.4 -0.7 -1.9 0.3 1.0 1.2 1.0 1.0
Osteoarthritis (self-reported) 1.9 2.4 5.6 2.0 -0.4 -2.4 -0.7 -1.7 -0.6 -1.8
Medication: Aspirin 0.5 0.7 1.7 0.2 1.3 -1.0 -1.3 -0.1 0.1 -0.6
Medication: Gliclazide 0.5 0.6 1.2 0.7 0.3 -1.0 -0.1 -1.1 -0.8 -0.9
Illnesses of father: None of the above (group 1) 1.1 1.3 8.1 0.7 0.1 -2.8 0.6 0.5 -0.2 0.4
Smoking status: Current 1.0 1.5 4.3 1.8 0.6 -0.2 -0.2 -1.2 -2.1 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 2.9 7.0 -1.5 2.6 0.1 0.5 1.7 1.6 2.4
Whole body water mass 0.3 1.6 4.8 2.2 1.0 -1.9 0.4 -0.1 -1.2 0.5
Leg predicted mass (right) 0.3 1.4 5.3 2.3 0.9 -1.6 0.3 -0.0 -1.0 0.3
Arm fat mass (left) 0.3 1.2 3.0 1.7 -0.4 -1.3 -0.9 -1.1 -0.8 -0.8
Number of self-reported non-cancer illnesses 0.6 1.1 2.9 -0.2 0.7 -1.4 -1.7 -0.6 0.5 -1.2
Average weekly champagne plus white wine intake 1.1 1.5 2.9 0.2 -1.7 1.4 -1.4 -0.3 -1.6 -1.1
Miserableness 0.2 0.3 0.9 0.3 -0.3 0.2 -0.7 0.9 -0.0 0.5
Guilty feelings 0.2 0.3 0.8 -0.7 0.4 0.4 0.1 0.9 0.5 0.4
Wears glasses or contact lenses 0.5 0.6 1.7 0.7 -0.3 -1.1 0.0 -1.3 -0.8 -0.3
Ever taken oral contraceptive pill 0.5 0.6 1.4 -1.0 -0.6 0.8 -1.2 0.4 -0.1 -0.8
Hearing aid user 1.0 1.1 2.8 -1.4 -1.7 1.2 -0.8 -0.1 0.8 -0.5
Mother’s age at death 0.4 0.5 2.2 -0.5 1.5 -0.7 -0.2 0.3 -0.2 -0.4
Financial situation satisfaction 1.5 1.8 4.0 1.0 0.6 -1.8 -0.1 -1.4 -2.0 -1.5
Tinnitus: Yes, now most or all of the time 0.8 1.0 2.9 -0.9 -0.6 1.7 0.7 0.5 0.8 1.2
Commuting to job workplace: Public transport 0.4 0.5 1.5 0.2 -0.6 0.1 1.2 0.2 -0.5 1.2
Eye problems/disorders: Glaucoma 0.3 0.4 1.0 -0.1 -0.6 -0.1 -0.0 -1.0 -0.6 -1.0
Medication: Blood pressure 0.2 0.4 1.5 0.5 -1.2 -1.0 0.4 0.2 0.2 -0.2
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.0 0.4 0.6 -1.0 -0.1 0.2 0.5 -0.0
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.0 -1.4 0.7 1.1 -1.3 0.1 0.1 -0.3
High cholesterol (Self-reported) 0.2 0.4 1.1 -1.0 0.1 0.1 -0.2 0.6 0.9 0.6
Medication: Bendroflumethiazide 0.4 0.6 1.6 -0.4 -0.6 -1.1 -1.3 -0.3 -0.2 -0.8
Medication: Paracetamol 0.3 0.4 1.0 -0.8 -0.2 -0.2 0.7 0.4 1.0 0.8
Medication: Lisinopril 1.5 1.9 6.9 0.5 -2.6 1.4 -0.5 1.6 0.2 1.2
Medication: Atorvastatin 0.4 0.5 1.6 0.5 1.0 -1.3 -0.1 -0.9 0.1 -0.3
Illnesses of father: High blood pressure 0.5 0.6 2.4 0.1 -0.0 1.6 0.7 0.5 0.6 1.0
Alcohol drinker status: Never 1.0 1.2 3.7 1.4 -1.9 -0.3 0.9 -0.0 -0.8 1.0
Ever smoked 0.7 1.2 3.5 0.6 1.2 -1.5 -0.4 -0.7 -1.9 -0.5
Basal metabolic rate 0.3 1.6 5.6 2.4 0.9 -1.8 0.2 -0.3 -1.2 0.2
Leg fat percentage (left) 0.5 1.7 2.9 1.5 -0.4 -0.8 -1.7 -1.6 -1.5 -1.2
Arm fat-free mass (left) 0.4 2.0 6.1 2.5 1.0 -2.0 -0.1 -0.6 -1.6 0.0
Number of operations (self-reported) 1.3 2.0 4.1 1.2 -1.0 -0.1 -1.9 -2.0 0.2 -2.0
Average weekly beer plus cider intake 0.9 1.3 7.1 -2.7 0.4 0.9 0.0 0.7 0.2 0.6
Irritability 0.5 0.9 3.3 0.6 -0.2 -1.0 0.8 0.6 1.8 0.6
Risk taking 0.9 1.4 3.7 0.9 -0.8 -0.2 -1.6 -0.5 -1.9 -1.3
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.4 0.1 -0.7 1.2 -1.0 0.6 0.8 0.4
Fractured/broken bones in last 5 years 1.1 1.4 5.2 1.7 0.6 -0.4 2.3 -0.1 0.8 1.0
Age started oral contraceptive pill 2.2 2.8 7.7 -2.3 -1.9 0.2 -2.8 -0.4 -1.3 -0.9
Diastolic blood pressure, automated reading 0.3 1.0 3.8 -0.9 -0.0 0.7 -1.9 -0.5 -0.5 -1.1
Ever depressed for a whole week 0.3 0.4 2.1 1.4 0.2 -0.3 0.8 -0.3 -0.1 -0.1
Unable to work because of sickness or disability 0.4 0.5 1.3 -0.2 1.2 -0.6 0.2 -0.8 -0.8 -0.6
Commuting to job workplace: Cycle 0.4 0.5 1.0 0.5 1.0 -0.5 0.5 -1.0 -0.9 -0.4
Myopia 0.5 0.7 1.6 -0.4 -0.2 -0.0 1.3 0.8 1.2 1.0
Vascular/heart problems diagnosed by doctor 0.3 0.8 3.3 0.3 0.1 1.1 1.8 -0.0 0.7 0.7
Cholesterol lowering medication 0.2 0.3 1.1 -0.4 0.8 0.4 -1.0 0.4 -0.1 -0.3
Medication: Omeprazole (e.g. Zanprol) 1.7 2.0 4.5 -0.9 -0.6 -0.3 1.5 2.1 1.6 1.9
Pain experienced in last month 2.7 4.6 8.9 -1.6 -1.0 1.9 1.8 2.7 3.0 2.3
Supplements: Calcium 1.6 1.8 4.7 -0.7 0.8 1.7 0.3 2.2 1.7 0.9
Basal cell carcinoma (self-reported) 0.8 0.9 3.6 -0.9 -0.7 1.9 -0.1 0.6 0.9 0.5
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.5 0.2 0.8 -0.9 -1.1 -1.0 0.3 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.3 1.5 -0.9 -0.4 -0.5 -1.1 -0.3 -1.1
Heart disease (siblings) 0.7 0.8 1.8 -1.3 1.3 0.5 -1.2 -0.3 0.9 -0.0
Alcohol drinker status: Previous 0.7 0.8 3.2 0.3 1.8 -1.5 -0.4 -0.4 0.2 -0.1
Pack years of smoking 0.5 0.7 3.1 -0.4 -1.8 -0.2 -0.8 -0.5 -0.3 -0.6
Impedance of whole body 0.3 1.5 6.9 -1.1 -0.6 2.6 0.2 0.3 1.4 -0.2
Leg fat mass (left) 0.4 1.5 3.8 2.0 0.1 -1.2 -1.0 -1.3 -1.4 -0.8
Arm predicted mass (left) 0.4 2.0 5.5 2.4 1.1 -2.2 0.0 -0.5 -1.4 0.2