TWAS hub - BCL2L13

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1890	0.0380	2.5e-08	0.092	0.086	0.113	0.114	0.125	2.5e-11	1.3e-10	1.3e-13	1.1e-13	5.9e-15
2	GTEx	Cells Transformed fibroblasts	0.2100	0.0570	2.5e-04	0.013	NA	0.004	NA	0.013	3.5e-02	NA	1.6e-01	NA	3.4e-02
3	GTEx	Skin Sun Exposed Lower leg	0.1080	0.0400	3.4e-03	0.018	NA	0.061	NA	0.053	1.1e-02	NA	9.3e-06	NA	3.4e-05
4	YFS	Blood	0.0784	0.0131	0.0e+00	0.068	0.084	0.095	0.099	0.095	2.6e-21	5.0e-26	1.5e-29	1.6e-30	1.8e-29
5	TCGA	Breast Invasive Carcinoma	0.0218	0.0110	4.9e-03	0.017	0.002	0.008	NA	0.009	1.5e-04	1.3e-01	7.8e-03	NA	5.4e-03
6	TCGA	Colon Adenocarcinoma	0.2730	0.0870	9.4e-05	0.105	0.050	0.086	NA	0.080	1.3e-06	7.6e-04	1.1e-05	NA	2.2e-05
7	TCGA	Pheochromocytoma and Paraganglioma	0.2180	0.0950	1.2e-03	0.068	0.096	0.097	NA	0.091	1.1e-03	1.2e-04	1.1e-04	NA	1.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Exposure to tobacco smoke outside home	3.9	5.2	16.9	-4.1	-2.2	1.4	3.4	-0.1	-1.0	-0.4
Leg fat mass (right)	3.9	15.1	42.0	-5.9	-3.5	1.7	6.5	-1.6	-1.9	-2.8
Leg fat mass (left)	3.8	14.9	41.7	-6.0	-3.5	2.0	6.5	-1.0	-1.5	-2.7
Pulse wave Arterial Stiffness index	3.7	4.3	10.9	-1.8	-1.9	2.9	1.1	1.7	0.1	3.3
Leg fat percentage (right)	3.6	12.9	34.7	-5.3	-3.3	1.7	5.9	-1.6	-1.7	-2.8
Pulse wave peak to peak time	3.6	4.3	11.5	1.7	1.9	-2.9	-1.0	-1.6	-0.1	-3.4
Leg fat percentage (left)	3.6	13.0	34.9	-5.5	-3.4	2.0	5.9	-1.1	-1.4	-2.6
Waist circumference	3.1	11.2	30.6	-5.3	-2.9	2.5	5.5	-0.0	-0.6	-2.3
Whole body fat mass	3.1	13.0	34.3	-5.8	-3.1	2.0	5.9	-0.7	-1.3	-2.7
Arm fat mass (right)	2.9	11.7	31.1	-5.6	-3.1	2.1	5.5	-0.4	-0.9	-2.3
Osteoarthritis (self-reported)	2.8	3.6	8.6	0.3	1.7	-2.9	0.0	-2.5	-1.6	-2.2
Body fat percentage	2.7	10.7	29.7	-5.4	-2.9	1.9	5.1	-0.5	-1.0	-2.4
Arm fat mass (left)	2.7	10.9	28.7	-5.4	-3.0	1.6	5.3	-0.8	-1.3	-2.4
Trunk fat mass	2.6	11.3	30.0	-5.5	-2.9	1.9	5.4	-0.6	-1.2	-2.5
Angina	2.5	3.3	10.0	-0.9	-1.5	-1.5	-0.3	-2.3	-3.2	1.4
Body mass index (BMI)	2.5	10.7	27.6	-5.0	-3.3	1.8	5.3	-0.9	-1.7	-2.3
Neck or shoulder pain in last month	2.5	3.5	7.3	-2.3	-1.0	-1.1	2.0	-1.9	-2.7	-1.3
Average weekly spirits intake	2.4	3.0	8.6	-0.4	-0.7	2.2	-0.6	2.9	2.2	1.3
Trunk fat percentage	2.4	9.4	27.7	-5.3	-2.7	1.9	4.7	-0.3	-0.8	-2.1
Weight	2.4	11.8	30.5	-5.3	-3.2	1.9	5.5	-1.0	-1.8	-2.4
Angina (self-reported)	2.4	3.1	9.4	-0.6	-1.2	-1.7	-0.5	-2.4	-3.1	1.4
Commuting to job workplace: Public transport	2.4	2.8	7.2	1.9	2.7	-1.4	-2.4	0.5	0.6	0.7
BMI	2.3	13.1	35.1	-5.5	-3.6	3.0	5.9	-0.4	-1.4	-1.7
Comparative body size at age 10	2.3	6.4	16.3	-3.0	-4.0	2.4	3.0	0.3	-1.2	1.7
Hip circumference	2.2	9.6	23.2	-4.8	-3.4	2.3	4.7	-0.5	-1.5	-1.7
Financial situation satisfaction	2.2	2.7	7.0	-1.9	-0.3	-1.2	1.9	-2.6	-1.3	-1.1
Medication: Co-codamol	2.1	2.4	7.1	-0.5	0.0	-2.4	-0.4	-2.7	-1.9	-0.4
Arm fat percentage (right)	2.1	8.1	23.7	-4.9	-2.4	1.6	4.4	-0.4	-0.7	-2.1
Tense / ‘highly strung’	2.0	3.3	6.8	2.4	1.7	0.7	-2.6	1.8	1.7	1.2
Pulse wave reflection index	2.0	2.5	7.7	-0.1	-1.6	2.0	-0.6	1.5	0.5	2.8
Arm fat percentage (left)	2.0	8.0	22.4	-4.7	-2.4	1.5	4.4	-0.5	-1.1	-2.3
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	5.0	1.7	2.2	-1.5	-1.2	-1.1	-1.7	-1.1
Pulse rate	1.9	3.2	6.3	-1.8	-2.5	2.0	1.9	-0.6	-1.2	1.8
Medication: Ibuprofen	1.9	2.2	4.7	-2.2	-1.8	0.5	1.9	-1.1	-1.5	-0.4
Worry (Nagel 2018)	1.8	3.7	11.0	2.4	2.7	-1.2	-3.3	0.5	0.3	0.7
Blood White Count	1.8	13.1	51.3	-1.1	5.0	-2.4	2.0	0.2	2.1	-7.2
Qualifications: None of the above	1.8	3.9	12.7	-3.6	-0.6	1.5	3.0	0.0	0.2	-1.7
Blood Eosinophil Count	1.7	12.9	39.1	1.4	6.2	-3.4	0.4	-0.3	1.1	-6.0
Age when periods started (menarche)	1.7	4.0	10.2	2.1	2.4	-3.2	-2.2	-1.5	-0.2	-0.9
Had menopause	1.7	2.1	3.8	-0.9	0.4	1.4	2.0	1.1	1.9	-1.7
Medication: Lansoprazole	1.7	1.9	5.6	-1.7	-0.1	-1.8	0.3	-1.3	-2.4	0.1
Wheeze or whistling in the chest in last year	1.7	3.0	6.8	-2.6	-1.4	-0.7	1.6	-1.6	-2.6	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	3.8	-1.7	-0.3	-0.2	2.0	-1.3	-1.7	-1.6
Alzheimer’s Disease (in father)	1.6	1.7	3.8	-2.0	-0.3	-0.8	1.8	-1.2	-1.6	-0.4
Blood Red Count	1.6	15.1	45.3	-5.4	-3.4	4.4	6.7	0.5	-0.1	-0.6
Smoking Status	1.6	3.8	10.1	-2.2	-1.9	1.1	3.2	-1.8	-0.5	-1.9
Length of working week for main job	1.6	1.7	4.8	-1.2	-2.2	1.9	0.9	0.9	0.6	-0.4
Loud music exposure frequency	1.6	1.7	4.4	-1.2	-0.7	1.3	2.1	0.8	1.8	-0.8
Eye problems/disorders: None of the above	1.6	1.8	4.1	-1.2	-0.9	-0.1	1.4	-1.1	-2.0	1.8
Ovarian Cancer	1.5	2.0	5.2	1.1	1.5	1.0	2.0	0.7	0.5	-2.3
Serious illness, injury or assault to yourself	1.5	1.8	4.1	1.2	1.3	-1.7	-2.0	-0.8	-1.2	-0.2
Exposure to tobacco smoke at home	1.5	1.7	3.5	-1.7	-1.6	1.2	1.9	0.8	0.1	0.9
Medication for pain relief, constipation, heartburn	1.5	2.5	5.6	2.4	1.4	0.3	-1.9	1.6	2.1	0.5
Number of full sisters	1.5	1.8	7.2	-2.7	-1.1	-0.3	1.7	-0.4	-0.9	-0.1
Overall health rating	1.5	3.2	9.3	-3.0	-1.6	0.2	2.0	-0.6	-2.4	-0.4
Chest pain or discomfort	1.5	2.2	9.4	0.1	-0.5	-1.6	-0.6	-1.2	-3.1	1.0
Commuting to job workplace: Car/motor vehicle	1.5	1.8	5.2	-1.5	-1.9	0.4	2.3	-0.9	-0.4	-0.4
Long-standing illness, disability or infirmity	1.5	2.4	6.3	0.4	1.1	-2.3	-0.8	-1.5	-2.5	-0.7
Illnesses of father: None of the above (group 1)	1.5	1.9	4.9	1.6	2.2	-1.3	-0.8	-0.2	-0.4	-1.8
Stomach or abdominal pain in last month	1.4	1.7	7.5	-0.1	-1.2	2.7	0.6	1.6	0.7	-0.2
Medication: Atenolol	1.4	1.7	4.1	0.9	-0.7	-1.1	-1.5	-1.2	-2.0	1.4
Nervous feelings	1.4	2.6	7.1	0.9	1.2	0.1	-2.0	1.9	1.1	2.7
Medication: Cholesterol lowering	1.4	2.2	6.9	0.1	0.1	-1.8	-0.6	-2.1	-2.6	-0.6
Migraine (self-reported)	1.4	1.8	4.6	-0.1	1.1	-1.6	0.8	-1.3	-1.4	-2.2
Arm predicted mass (right)	1.4	7.1	18.6	-3.5	-3.1	1.5	4.3	-1.2	-1.8	-1.5
Medication: Lisinopril	1.4	1.8	4.0	-0.9	-2.0	0.3	0.5	-0.8	-1.7	1.9
Basal metabolic rate	1.4	7.6	18.7	-4.1	-3.1	1.6	4.3	-1.0	-1.7	-1.3
Number of operations (self-reported)	1.4	2.1	3.6	-1.7	-1.9	1.2	1.9	-0.8	-1.6	-0.2
Average weekly beer plus cider intake	1.4	2.1	4.9	-1.2	-0.8	-0.5	2.2	-1.9	-1.6	-1.3
Pain experienced in last month	1.4	2.4	4.3	2.0	2.1	-1.3	-1.2	0.4	1.7	-1.4
Arm predicted mass (left)	1.4	7.3	17.8	-4.0	-3.1	1.4	4.2	-1.2	-1.8	-1.4
Coronary Artery Disease (CAD)	1.3	1.5	3.4	-0.1	1.1	1.1	1.6	0.6	1.3	-1.9
HbA1C	1.3	1.5	4.1	-1.7	-0.8	1.5	2.0	0.2	-0.4	-0.0
Leg fat-free mass (left)	1.3	6.7	16.4	-3.9	-2.8	1.4	4.0	-1.0	-1.9	-1.0
Leg predicted mass (left)	1.3	6.8	16.5	-4.0	-2.8	1.5	4.1	-1.0	-1.8	-1.0
Past tobacco smoking	1.3	2.5	6.3	2.3	1.2	-1.0	-2.5	0.4	0.1	1.7
Diabetes (self-reported)	1.3	2.0	5.0	-0.8	0.1	-0.7	2.2	-1.3	-1.6	-1.9
Prospective memory result	1.3	1.6	5.6	0.2	-0.8	-0.3	-0.4	-2.1	-2.4	0.6
Friendships satisfaction	1.3	1.6	3.5	1.4	1.9	-0.8	-1.2	1.1	1.4	-0.5
Medication: Gliclazide	1.3	1.5	3.8	1.9	1.4	-1.6	-1.3	-0.4	-0.4	-0.3
Arm fat-free mass (left)	1.3	6.7	17.8	-3.6	-2.8	1.3	4.2	-1.2	-1.5	-1.6
Type 2 Diabetes (T2D) (2018)	1.2	2.2	7.3	-1.2	-1.5	0.5	2.7	-1.1	-1.4	-0.8
Medication: Metformin	1.2	1.7	3.5	-0.2	-0.2	-1.3	1.7	-1.9	-1.1	-1.6
Had other major operations	1.2	1.4	2.8	-1.2	-1.6	0.4	0.9	-0.8	-1.7	1.2
Worrier / anxious feelings	1.2	2.3	4.8	0.9	1.2	-1.8	-2.2	-1.0	-1.4	1.8
Falls in the last year	1.2	1.6	3.4	-1.8	-1.1	1.7	0.2	1.7	0.4	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.1	-1.8	-1.4	0.7	1.7	-0.8	-1.3	-0.4
Depression (self-reported)	1.2	1.4	7.4	0.6	0.2	-0.9	-2.7	-0.7	-0.7	0.1
Arm fat-free mass (right)	1.2	6.3	16.4	-3.3	-2.9	1.2	4.1	-1.3	-1.9	-1.4
Suffer from ‘nerves’	1.2	1.8	3.8	1.4	2.0	0.2	-1.3	1.4	1.8	0.0
Illnesses of father: Heart disease	1.2	1.6	4.3	-0.9	-2.1	-0.1	0.3	-0.7	-1.7	1.6
Back pain experienced in last month	1.2	1.8	5.0	-1.6	-2.2	1.2	0.8	-0.7	-1.4	0.5
Crohns Disease (2012)	1.1	1.8	4.2	0.1	-1.1	-1.0	-0.3	-2.1	-1.8	1.6
Chronotype (morning person)	1.1	2.4	7.6	1.5	1.8	-0.7	-1.0	1.0	1.2	-2.8
Supplements: Glucosamine	1.1	1.4	4.7	0.3	0.5	-0.5	1.5	-1.4	-0.4	-2.2
Illnesses of mother	1.1	1.4	6.3	0.3	-0.5	0.7	-1.0	1.1	0.5	2.5
Glaucoma (self-reported)	1.1	1.3	2.5	-0.7	0.1	1.6	1.3	1.4	0.9	-1.2
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.3	0.3	0.1	0.7	-1.8	1.8	0.8	1.4
Supplements: Vitamin C	1.1	1.3	2.7	1.6	1.2	-0.6	-1.6	0.1	0.5	1.4
Commuting to job workplace: Walk	1.1	1.2	3.1	0.1	1.6	-0.9	-0.8	1.1	1.8	0.0
Eye problems/disorders: Glaucoma	1.1	1.3	2.7	-0.4	0.2	1.5	0.9	1.4	1.7	-1.2
Medication: Atorvastatin	1.1	1.4	4.1	-0.1	-0.3	-1.0	-1.6	-0.3	-2.0	1.5
Ever smoked	1.1	1.9	5.5	-1.4	-0.7	0.6	2.3	-0.9	-0.2	-2.0
Rheumatoid Arthritis	1.0	1.4	3.2	-1.2	-1.6	-0.9	1.3	-1.8	-0.7	-0.1
Type 2 Diabetes (T2D) (2012)	1.0	1.2	4.4	-1.4	-0.3	0.5	2.1	-1.1	-0.2	-0.7
Number of treatments/medications taken	1.0	1.8	6.6	-1.2	0.1	-0.8	0.4	-1.6	-2.6	-0.9
Current tobacco smoking	1.0	1.7	4.8	-0.9	-0.4	0.0	2.2	-1.9	-1.0	-1.2
Number of incorrect matches in round	1.0	1.6	3.1	1.2	1.5	-1.5	-1.2	-0.9	-0.1	-1.8
Pain all over the body in last month	1.0	1.1	2.2	-1.0	-1.3	0.9	1.5	-0.6	-1.3	0.2
Hair/balding pattern: Pattern 4	1.0	2.3	6.4	0.3	-0.4	-1.7	-0.7	-2.5	-2.3	-1.0
Medication: Paracetamol	1.0	1.7	5.0	-2.2	-1.6	1.3	1.5	0.0	-0.6	0.5
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.9	-0.4	-1.7	0.5	-0.6	0.4	-0.6	2.2
Knee pain experienced in last month	1.0	1.6	3.9	-2.0	-0.6	-0.3	1.8	-1.3	-1.1	-0.6
Whole body fat-free mass	1.0	5.8	13.8	-3.4	-2.9	1.4	3.7	-1.0	-1.7	-0.9
Leg fat-free mass (right)	1.0	5.4	12.9	-3.6	-2.6	1.4	3.6	-0.6	-1.6	-0.7
Mineral and other dietary supplements	1.0	1.4	3.3	-0.1	-1.3	0.7	-1.4	1.4	0.7	1.8
Breast cancer (self-reported)	1.0	1.2	1.9	-1.0	-0.9	1.4	1.2	1.4	1.1	-0.5
Whole body water mass	1.0	5.7	14.0	-3.4	-2.8	1.3	3.7	-1.0	-1.7	-1.1
Leg predicted mass (right)	1.0	5.4	13.0	-3.6	-2.6	1.3	3.6	-0.7	-1.6	-0.6
Average weekly champagne plus white wine intake	1.0	1.3	5.3	0.1	0.8	0.6	0.5	1.6	2.3	0.6
Fractured/broken bones in last 5 years	1.0	1.3	4.0	-0.2	0.7	-2.0	-0.9	-1.8	-0.1	0.9
Age started oral contraceptive pill	1.0	1.2	2.6	-0.2	1.2	-1.1	1.6	-1.2	-0.1	-1.3
Diastolic blood pressure, automated reading	1.0	3.1	7.3	-2.4	-2.7	1.7	1.6	0.1	-0.9	1.6
Heart disease (siblings)	1.0	1.2	4.2	0.3	1.0	-1.6	-0.2	-0.5	-0.3	-2.0
Neuroticism (Nagel 2018)	0.9	2.0	3.6	1.8	1.9	-1.6	-1.8	-0.8	-0.9	-0.1
Sensitivity / hurt feelings	0.9	1.6	4.1	-0.1	0.3	-1.6	-1.1	-1.7	-2.0	0.4
Ever had hysterectomy (womb removed)	0.9	1.0	3.0	-1.7	0.9	-0.8	1.3	-0.7	-0.6	-0.3
Medication for hormone replacement therapy	0.9	1.0	2.6	-0.2	1.5	-0.8	0.3	-0.7	-0.9	-1.6
Townsend deprivation index at recruitment	0.9	1.3	6.0	-2.4	0.5	0.1	1.5	0.3	0.4	-0.7
Multivitamins +/- minerals	0.9	1.2	2.4	1.4	1.5	0.6	-0.0	1.2	1.4	-0.6
Financial difficulties in last 2 years	0.9	1.2	2.4	0.7	1.6	-1.5	-0.3	-1.2	0.1	-1.2
Medication: Ramipril	0.9	1.1	2.9	-0.4	1.7	-1.6	-0.6	-0.7	-0.6	-1.2
Father’s age at death	0.9	1.2	2.2	-1.5	-0.8	1.2	1.5	0.7	0.9	0.9
Medication: Seretide 50 evohaler	0.9	1.0	2.1	0.0	-1.1	-1.4	-0.8	-0.7	-0.9	1.4
Pulse rate, automated reading	0.9	2.8	10.4	-2.1	-1.3	1.2	3.2	-0.6	-1.1	0.6
Leg pain on walking	0.9	1.1	3.6	-0.6	0.1	-1.3	0.7	-0.9	-1.9	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.5	-0.6	-0.4	-0.5	1.6	-1.1	-0.7	-1.6
Illnesses of siblings: Diabetes	0.9	1.0	4.2	-1.0	0.6	-0.6	1.0	-0.2	0.5	-2.1
Smoking status: Previous	0.9	1.3	2.9	-1.7	-1.4	1.0	1.6	0.1	-0.0	-0.7
Smoking status: Current	0.9	1.5	4.0	-0.4	-0.1	0.1	2.0	-1.8	-0.7	-1.5
Unable to work because of sickness or disability	0.9	1.1	5.5	-2.4	-1.1	0.7	0.4	0.5	-0.6	0.3
Supplements: Calcium	0.9	1.0	2.4	1.3	1.6	-1.3	-1.0	-0.2	0.4	0.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	3.7	-0.9	-1.0	0.3	0.8	-0.5	-1.0	-1.9
Schizophrenia (2018)	0.8	1.6	3.7	0.7	0.8	1.0	-0.8	1.8	1.9	1.0
Schizophrenia (2014)	0.8	1.7	3.8	1.7	1.1	0.9	-0.9	1.5	2.0	0.2
Ulcerative Colitis	0.8	1.1	3.1	1.2	0.5	-0.9	-0.2	-1.8	-0.2	-1.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.2	0.8	-0.5	-0.1	0.2	-1.2	-1.3	-1.5
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.8	-1.7	-0.8	0.3	1.3	-0.5	-0.8	-0.6
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.7	-0.5	-0.8	1.4	1.6	0.9	0.1	-0.7
Trunk fat-free mass	0.8	4.5	11.2	-2.8	-2.6	1.2	3.4	-1.0	-1.4	-1.1
Trunk predicted mass	0.8	4.5	11.6	-2.8	-2.5	1.2	3.4	-1.0	-1.5	-1.1
Blood clot in the leg (DVT)	0.8	1.1	3.7	-1.0	-1.0	0.4	1.0	-0.4	-0.7	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.8	1.4	1.7	-0.0	-1.3	-0.5	-0.2	-0.5
Qualifications: College or University degree	0.8	2.7	8.0	1.8	0.6	-1.0	-2.4	0.5	-0.2	2.8
Alcohol intake frequency.	0.8	1.8	4.2	-1.9	-2.0	0.9	0.8	-0.3	-1.6	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.8	-0.2	0.6	-1.5	0.8	-1.7	-0.8	-0.3
Guilty feelings	0.8	1.2	2.7	-0.5	1.6	-1.7	0.0	-1.1	-0.6	-1.1
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.3	-0.4	1.2	0.4	1.8	-0.8	-0.6	-1.2
Pack years of smoking	0.8	1.1	2.2	-1.0	-0.9	1.5	1.5	0.2	0.7	-1.1
Prostate Cancer	0.7	0.9	2.4	0.6	-0.7	1.6	-0.7	1.3	0.4	1.1
Body Mass Index (BMI) (2010)	0.7	1.0	2.6	-1.6	-1.0	1.0	1.4	0.2	0.3	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.0	-0.9	-0.4	1.1	0.2	1.4	1.4	0.2
Taking other prescription medications	0.7	1.0	3.0	-0.2	0.5	-1.4	-0.7	-1.2	-1.7	-0.1
Medication: Levothyroxine sodium	0.7	1.1	2.0	0.3	0.8	-1.3	0.8	-1.3	-1.4	-1.1
Chronic bronchitis/emphysema (father)	0.7	0.8	1.1	-0.9	-0.9	0.8	0.9	1.0	1.0	-0.5
High blood pressure (mother)	0.7	0.9	2.8	0.3	0.7	-1.7	-0.8	-1.1	-0.8	-0.7
Medication: Simvastatin	0.7	1.1	4.1	-1.3	0.1	-0.2	2.0	-0.4	-0.8	-0.9
Illnesses of siblings	0.7	1.0	3.4	1.3	-0.7	1.0	-0.2	0.3	-0.0	1.9
Impedance of arm (right)	0.7	3.3	6.5	1.4	2.4	-0.5	-2.5	1.4	2.2	1.2
Hair/balding pattern: Pattern 3	0.7	1.0	2.2	-0.2	-0.3	1.2	1.0	1.3	1.5	1.0
Mouth/teeth dental problems: Dentures	0.7	1.2	3.8	-0.1	0.2	-0.8	0.4	-1.3	-1.3	-2.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.7	1.4	-0.0	-0.6	-1.3	0.5	-0.2	1.9
Number of full brothers	0.7	0.9	4.7	-0.0	0.4	-0.5	0.9	0.1	0.4	-2.2
Number of children fathered	0.7	0.8	1.8	0.3	-0.7	-1.1	0.2	-1.4	-1.3	-0.2
Medication: Blood pressure	0.7	1.3	4.1	-0.4	0.3	-2.0	-1.4	-0.7	-1.4	0.3
Diabetes diagnosed by doctor	0.7	1.1	3.0	-0.1	0.3	-0.4	1.7	-0.9	-1.2	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.3	-0.9	-1.5	1.1	0.2	0.7	-0.0	0.8
Eye problems/disorders: Cataract	0.7	0.8	2.0	0.5	-0.4	0.7	-1.0	1.4	1.2	-0.2
Medication: Aspirin	0.7	1.0	2.1	0.8	0.4	-1.1	-1.1	-1.2	-1.5	0.4
Mother’s age at death	0.7	0.9	3.3	1.8	0.9	0.4	-0.1	0.4	1.3	-0.4
Medication: Paracetamol	0.7	1.1	4.0	-2.0	-0.9	0.2	1.0	-0.6	-1.1	-0.4
Myopia	0.7	1.1	2.2	-1.5	0.0	1.0	1.5	0.4	-0.9	1.1
Crohns Disease (2017)	0.6	1.4	3.8	-0.4	-2.0	-0.4	-0.4	-1.1	-1.0	1.7
LDL Cholesterol	0.6	0.9	2.2	1.5	0.2	-0.5	-1.2	-0.5	-0.3	-1.5
Neuroticism (2016)	0.6	0.9	1.9	-1.4	0.3	-1.3	-0.2	-0.9	-0.8	0.9
Vitamin and mineral supplements	0.6	0.8	2.2	-0.7	-1.5	-0.4	-0.0	-1.0	-1.3	-0.1
Pack years adult smoking proportion	0.6	0.9	2.4	-0.5	-0.9	1.5	1.3	-0.1	0.5	-0.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.7	0.9	0.9	-1.3	-0.2	-0.8	-0.6	0.7
Asthma	0.6	1.3	2.7	-1.6	-0.9	-0.9	0.7	-0.9	-1.6	0.9
Breastfed as a baby	0.6	0.8	2.2	1.5	1.0	0.7	-0.5	0.7	1.0	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.8	1.7	0.9	0.2	-1.4	-0.2	0.3	0.7
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.9	-0.7	0.4	0.2	0.7	1.2	1.4	-0.6
Health satisfaction	0.6	0.8	2.4	-1.2	0.1	-0.6	0.7	-0.7	-1.5	-0.8
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.1	-1.5	0.0	0.1	0.8	0.6	0.3	1.2
Family relationship satisfaction	0.6	0.7	1.2	0.4	0.1	-1.0	-1.0	-1.1	-1.1	-0.2
Qualifications: nursing, teaching	0.6	1.0	4.5	-0.1	-1.1	-0.1	-1.1	0.1	-0.2	2.1
Asthma (self-reported)	0.6	1.2	2.5	-1.6	-1.0	-0.8	0.7	-1.1	-1.6	0.7
Osteoporosis (self-reported)	0.6	0.8	2.1	1.5	1.4	-0.7	-1.0	-0.1	0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.7	1.9	0.8	-0.3	-1.9	0.4	0.6	0.5
Ever taken oral contraceptive pill	0.6	0.6	2.2	-0.2	-1.3	-0.2	-0.1	0.5	0.4	1.5
Alcohol drinker status: Previous	0.6	0.6	1.6	-1.1	-1.2	0.1	0.2	-0.5	-1.3	0.1
Bipolar Disorder or Schizophrenia	0.5	1.1	2.1	1.2	0.8	0.9	-0.8	1.4	1.5	0.6
Depressed Affect (Nagel 2018)	0.5	1.0	2.7	0.9	0.1	-1.1	-0.5	-1.5	-1.6	0.3
Ulcerative Colitis (UC)	0.5	1.0	2.8	0.7	1.2	0.2	0.5	-0.2	1.4	-1.7
Major Depression (MDD)	0.5	0.7	1.8	0.2	-0.6	1.3	-1.0	1.2	-0.2	0.0
Mean Putamen Volume	0.5	0.5	1.5	0.5	0.7	-0.2	0.6	-0.6	-0.9	-1.2
Lupus	0.5	0.8	3.6	0.7	0.3	-0.3	-1.0	0.1	-0.4	1.9
Allergy or Eczema	0.5	1.3	4.4	1.0	2.1	-1.2	-1.4	0.2	0.4	-0.5
Lung FVC	0.5	2.5	6.5	1.9	-0.8	-0.6	-2.5	-0.8	-1.5	1.8
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.3	0.0	-1.0	0.9	-0.9	0.6	0.1	1.5
Severe depression (siblings)	0.5	0.6	1.0	-0.6	-0.2	-1.0	-0.9	-0.8	-0.8	0.7
Average weekly fortified wine intake	0.5	0.5	1.1	-0.8	-0.7	-0.5	0.1	-1.1	-0.7	0.8
Relative age voice broke	0.5	0.8	3.2	0.8	0.8	-0.2	-1.8	0.8	0.4	-0.3
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.0	1.2	1.3	-0.0	-1.4	0.9	1.1	-0.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.5	-0.6	0.8	0.3	1.2	-0.1	1.0	-0.8
Mouth/teeth dental problems	0.5	0.8	1.8	-0.5	-1.3	0.8	0.5	0.3	0.9	1.4
Happiness	0.5	0.6	1.9	-0.1	1.4	-0.4	0.5	0.5	0.7	-1.2
Noisy workplace	0.5	0.7	1.9	-0.5	0.4	-0.9	0.5	-1.4	-0.4	-1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	5.0	0.1	-0.3	-0.2	-0.9	1.0	0.9	2.2
Impedance of arm (left)	0.5	2.4	5.5	1.5	2.1	-0.7	-2.3	1.0	1.4	0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.3	-0.2	-0.2	1.5	1.3	0.7	1.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.3	0.5	0.3	-0.7	1.2	-0.7	-1.3	-1.5
Emphysema/chronic bronchitis	0.5	0.6	1.1	-0.3	-0.9	0.7	-0.5	0.8	0.7	1.1
Medication: Omeprazole	0.5	0.6	1.4	0.2	0.5	-0.7	-0.9	-0.9	-1.2	0.4
Age at last live birth	0.5	0.7	2.3	0.5	-0.3	-1.5	-0.1	-1.3	-0.5	0.4
Loneliness, isolation	0.5	0.6	1.1	0.7	1.1	-0.4	-0.9	0.8	0.6	1.0
Number of self-reported non-cancer illnesses	0.5	0.9	3.4	-1.4	-0.2	-0.5	0.1	-0.5	-1.8	-0.6
Miserableness	0.5	0.8	2.3	-0.4	-0.1	-1.2	-0.2	-1.3	-1.5	0.5
Alcohol drinker status: Never	0.5	0.6	1.9	-0.7	-0.8	0.1	0.7	-0.5	-1.4	0.6
Schizophrenia vs Biploar Disorder	0.4	0.5	1.8	0.5	1.0	-0.3	-0.3	0.6	1.3	0.0
Alzheimer’s Disease (in mother)	0.4	0.5	0.7	0.7	0.8	0.8	0.6	0.7	0.9	-0.3
Reaction Time	0.4	0.7	2.8	1.0	-0.5	-0.2	-1.7	0.7	0.4	0.7
Breast Cancer	0.4	0.9	1.7	-0.9	0.0	-1.3	0.7	-1.3	-0.9	-1.0
Triglycerides	0.4	0.7	1.5	-1.2	-1.2	0.4	0.7	0.1	-0.6	0.8
Hand grip strength (left)	0.4	1.2	2.7	-0.5	-1.6	0.7	1.7	-1.0	-0.7	-0.7
Hand grip strength (right)	0.4	1.2	2.2	-0.5	-1.4	0.1	1.3	-1.4	-1.5	-0.4
Maternal smoking around birth	0.4	0.6	1.5	-0.2	-0.1	1.2	1.0	1.0	0.4	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	0.9	0.9	0.9	0.1	-1.0	0.7	0.7	0.9
Hearing difficulty/problems with background noise	0.4	0.7	1.6	0.8	1.2	-0.2	-0.8	0.3	-0.8	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.6	-1.6	-1.3	-0.5	0.6	0.0	0.4	-0.9
Time employed in main current job	0.4	0.5	2.1	-0.5	-0.1	-0.1	0.2	-0.8	-1.5	0.3
Alcohol intake versus 10 years previously	0.4	0.5	1.1	-1.1	-0.1	0.1	0.7	0.3	-0.9	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.3	-1.5	-0.8	0.5	0.8	0.2	-0.8	-0.6
Number of live births	0.4	0.6	1.6	-0.5	-0.8	-0.1	1.3	-0.9	-1.0	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.5	-0.1	-0.1	-0.8	0.1	-1.2	-0.8	0.3
Headache pain in last month	0.4	0.7	1.8	-1.2	-1.1	-0.0	0.3	-0.1	-1.3	0.6
High blood pressure (siblings)	0.4	0.6	1.8	-1.3	-0.7	0.3	0.9	0.6	0.4	-0.7
Forced vital capacity (FVC), Best measure	0.4	1.6	5.4	1.9	0.1	-0.9	-2.3	-0.9	-0.7	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.9	0.9	0.2	-0.3	-1.4	0.0	-0.2	0.6
Heart disease (mother)	0.4	0.5	2.6	-0.6	0.3	-0.5	0.0	-0.6	-1.6	0.0
Medication: Aspirin	0.4	0.5	1.4	0.4	-0.1	-0.7	-0.8	-0.7	-1.2	0.6
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.8	-0.4	-0.5	-0.8	0.3	-1.3	-0.2	-0.5
Wears glasses or contact lenses	0.4	0.5	1.4	1.2	0.1	0.1	-0.5	0.1	0.8	-1.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	2.0	-0.9	-0.1	0.2	0.5	0.4	0.2	-1.4
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	-0.9	0.7	-0.7	-0.8	0.6	0.3	-0.9
Medication: Bendroflumethiazide	0.4	0.6	2.0	-0.8	0.1	0.5	1.4	0.3	-0.9	-0.3
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.9	1.0	0.7	-0.2	-0.9	0.5	-0.0	-0.8
Ever depressed for a whole week	0.4	0.5	1.3	-1.0	-0.1	-0.2	1.1	-0.9	0.4	-0.1
Commuting to job workplace: Cycle	0.4	0.5	1.2	-0.1	1.1	-0.9	-0.0	-0.2	-0.7	-0.8
Cholesterol lowering medication	0.4	0.5	2.6	0.4	0.3	0.3	0.4	1.6	0.6	0.5
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	0.6	-0.2	0.8	-0.4	1.1	-1.0	0.4
Impedance of whole body	0.4	2.1	4.7	1.3	1.9	-0.4	-2.2	1.1	1.7	0.6
Depression (Nagel 2018)	0.3	0.5	1.6	0.1	-1.0	0.5	-0.4	0.1	-0.4	1.3
Alzheimer’s Disease (including proxy)	0.3	0.4	1.5	-0.1	0.2	0.1	1.2	-0.6	-0.3	-0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.1	0.2	-0.9	0.6	0.2	1.4	0.6	1.3
Bipolar Disorder (2011)	0.3	0.3	1.9	0.0	0.0	0.0	-1.4	0.3	0.0	0.0
HDL Cholesterol	0.3	0.5	1.3	0.3	0.6	0.6	0.2	0.8	1.2	-0.9
Hypothyroidism (self reported)	0.3	0.7	2.1	0.3	-0.1	-0.7	0.8	-1.0	-1.5	-0.6
Respiratory disease	0.3	0.6	1.7	-0.4	-0.1	-1.3	-0.2	-0.8	-1.3	0.5
Neuroticism	0.3	0.8	2.0	0.1	0.9	-0.8	-1.4	-0.2	-0.6	1.3
Tanning	0.3	3.1	5.4	1.1	1.7	-2.3	-1.6	-1.9	-0.9	-2.3
Systolic blood pressure, automated reading	0.3	0.9	3.0	-1.7	-1.5	0.5	0.4	-0.3	-0.7	0.3
Diabetes (father)	0.3	0.4	1.0	0.7	-0.2	0.0	0.1	0.6	1.0	-1.0
Diabetes (mother)	0.3	0.4	1.7	-0.3	-1.3	0.7	0.5	0.0	-0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	-1.1	-0.9	-0.7	0.8	-0.6	-0.4	-1.1
Qualifications: CSEs or equivalent	0.3	0.4	1.0	0.1	0.1	1.0	0.7	-0.0	0.9	-0.8
Alcohol usually taken with meals	0.3	0.4	1.4	1.2	0.1	-0.3	-0.4	0.1	0.3	1.1
Forced vital capacity (FVC)	0.3	1.1	3.6	1.9	0.2	-0.2	-1.8	-0.6	-0.7	0.4
Heart attack	0.3	0.4	1.2	-0.2	-0.9	-0.3	-0.1	-1.1	-0.9	-0.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	-0.3	1.0	-0.6	-0.2	-0.2	0.4	-1.1
Neuroticism score	0.3	0.5	1.3	-0.3	0.9	-0.4	-1.1	0.3	-0.2	1.1
Medication: Amlodipine	0.3	0.4	0.8	-0.8	-0.9	-0.6	-0.7	-0.2	-0.4	0.7
Shortness of breath walking on level ground	0.3	0.4	1.6	-0.2	0.1	-0.5	0.7	-0.3	-1.3	-0.3
Mean time to correctly identify matches	0.3	0.5	2.4	0.2	0.1	-0.4	-1.5	0.7	0.0	0.7
Comparative height size at age 10	0.3	1.8	5.2	-1.9	-0.8	1.1	2.3	-0.7	-0.3	-1.2
Had major operations	0.3	0.4	1.4	-0.3	-0.8	0.7	-0.2	1.2	0.1	0.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.6	2.9	0.3	0.0	-0.5	-0.1	-0.8	-1.7	-0.2
Medication for cholesterol	0.3	0.4	1.1	-0.2	-0.5	1.0	0.4	0.3	1.0	-0.1
Hearing aid user	0.3	0.4	1.6	-0.4	-0.2	0.2	0.6	-0.4	-1.3	0.3
Illnesses of father: High blood pressure	0.3	0.3	0.9	-0.9	0.1	-0.2	-0.7	-0.3	0.2	0.9
Irritability	0.3	0.5	1.2	-0.1	0.1	1.0	0.3	1.1	1.1	0.0
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.2	1.4	0.7	0.6	-0.3	0.4	1.5	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.3	-0.6	-0.2	-0.1	-0.4	-0.6	-1.1	0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.8	-0.3	-0.9	-0.1	0.1	-0.9	-0.8	-0.4
Age at First Birth	0.2	0.3	1.0	0.3	1.0	-0.3	-0.8	0.6	0.1	0.5
Primary Biliary Cirrhosis	0.2	0.3	1.0	-0.3	-0.2	0.6	1.0	0.3	0.4	-0.1
Waist Hip Ratio (WHR)	0.2	0.7	1.8	-1.0	0.4	0.0	0.8	0.0	1.3	-1.2
Systolic Blood Pressure	0.2	0.8	2.9	-0.4	-0.1	-0.4	-1.7	0.3	-0.3	1.4
Cardiovascular Disease	0.2	0.7	3.1	-0.0	0.6	0.1	-0.9	1.8	0.4	0.5
Lung FEV1/FVC ratio	0.2	1.1	4.0	0.2	0.2	0.8	0.5	1.5	2.0	-0.5
Relative age of first facial hair	0.2	0.4	1.3	0.0	0.1	0.7	-0.9	0.3	0.2	1.2
Supplements: Zinc	0.2	0.2	0.6	0.8	-0.1	-0.6	-0.7	0.2	0.2	0.0
High blood pressure	0.2	0.5	1.6	-1.3	-0.1	-0.6	-0.0	0.2	-0.9	0.9
Impedance of leg (left)	0.2	0.9	2.7	0.8	0.9	0.2	-1.0	0.9	1.7	-0.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.7	1.3	0.3	0.5	-1.2	0.5	0.4	0.4
Lung cancer (father)	0.2	0.3	0.5	-0.1	0.1	-0.5	-0.7	-0.7	-0.4	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.0	1.4	0.3	-0.1	-1.4	0.1	0.5	0.6
Birth weight of first child	0.2	0.4	1.2	-0.6	0.3	-1.1	0.2	-0.7	-0.6	-0.1
Peak expiratory flow (PEF)	0.2	0.4	1.3	-0.6	-0.7	0.8	1.2	0.0	-0.4	-0.2
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	-0.7	0.8	-0.0	0.6	-0.0	-0.3	-0.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.1	0.4	1.0	-0.6	-0.2	0.1	0.1	-0.5
Birth weight	0.2	0.5	1.4	-0.6	-0.7	0.1	1.2	-0.6	-1.0	0.3
Age at first live birth	0.2	0.4	1.5	0.3	-0.4	-1.2	-0.7	-0.6	0.1	0.5
Medication: Allopurinol	0.2	0.3	0.8	0.2	-0.5	-0.3	-0.9	-0.2	-0.4	0.9
Hypertension (Self-reported)	0.2	0.5	1.3	-1.1	-0.1	-0.8	-0.2	0.1	-1.1	0.7
Average weekly red wine intake	0.2	0.3	1.0	0.2	0.1	-0.7	-0.3	-0.5	0.1	1.0
Mood swings	0.2	0.3	1.2	-0.2	-0.5	-0.1	0.3	-0.7	-1.1	-0.2
Ever had bowel cancer screening	0.2	0.3	0.5	-0.6	0.3	0.5	0.2	0.7	-0.4	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.9	0.4	-0.6	0.0	-1.0	0.3	-0.3	-0.1
Medication: Blood pressure	0.2	0.3	0.9	-0.5	-0.6	-0.3	0.3	-0.4	-0.9	0.4
High cholesterol (Self-reported)	0.2	0.3	0.9	0.5	0.6	-0.7	-0.6	0.1	-0.9	0.1
Risk taking	0.2	0.3	0.9	-0.4	-0.9	0.6	0.4	0.2	-0.4	0.4
Bipolar Disorder (2018)	0.1	0.2	1.1	1.1	0.2	0.1	-0.2	-0.3	0.1	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.8	0.5	-0.9	-0.4	0.5	-0.2	-0.1	0.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.9	0.3	-0.3	-0.2	0.0	-0.9	0.3	0.1
Fasting Glucose	0.1	0.1	0.5	-0.2	0.1	-0.5	0.0	-0.7	-0.1	-0.5
Blood Platelet Count	0.1	0.7	2.0	-1.4	-0.6	0.5	-0.0	0.9	0.7	1.1
Heel T-Score	0.1	0.8	2.5	-1.0	-1.6	0.9	0.3	0.4	-1.0	0.3
Height	0.1	2.6	9.2	-1.4	1.0	0.6	2.3	0.2	0.5	-3.0
Hearing difficulty/problems: Yes	0.1	0.2	0.4	-0.6	0.3	-0.1	-0.5	0.4	-0.6	0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.5	0.0	0.1	0.5	-0.1	-0.1	0.0
Impedance of leg (right)	0.1	0.6	1.6	1.0	0.7	0.4	-0.9	0.6	1.3	0.1
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	-0.6	0.2	0.0	0.5	-0.6	-0.2	-0.2
Allergy	0.1	0.3	0.9	0.5	0.5	-0.4	0.5	-1.0	-0.2	-0.6
Fluid intelligence score	0.1	0.2	0.9	0.4	-0.2	-0.2	1.0	0.5	0.2	0.2
Standing height	0.1	0.5	1.6	-1.3	-0.2	0.3	1.2	-0.3	-0.3	-0.6
Gout (self-reported)	0.1	0.1	0.4	0.6	0.4	-0.0	-0.4	-0.0	0.2	-0.1
Worry too long after embarrassment	0.1	0.2	1.4	-0.3	1.2	-0.1	-0.1	0.4	0.3	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.3	0.3	-0.3	-0.3	-0.4	-0.4	-0.6	0.3
Hair Pigment	0.0	0.9	2.9	0.3	-0.7	1.2	0.8	0.6	1.7	-0.9
Fed-up feelings	0.0	0.1	0.3	-0.5	0.2	0.3	0.4	-0.1	-0.1	-0.0
Sitting height	0.0	0.3	0.5	-0.7	-0.5	0.1	0.6	-0.2	-0.6	-0.6

Hub : Genes

BCL2L13

Models

Trait associations