Best TWAS P=1.17e-20 · Best GWAS P=1.25e-19 conditioned to 2.38e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AGPAT3 | 0.13 | 0.05 | bslmm | 446 | 0.07 | 4.4e-09 | -2.6 | -5.2 | 2.2e-07 | 0.15 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Esophagus Mucosa | RRP1B | 0.14 | 0.10 | enet | 13 | 0.11 | 8.0e-08 | -4.8 | -5.5 | 3.2e-08 | -0.05 | 0.04 | 0.94 | FALSE |
| 3 | GTEx | Esophagus Mucosa | PDXK | 0.29 | 0.18 | enet | 12 | 0.24 | 4.1e-16 | -4.5 | -5.4 | 7.2e-08 | 0.01 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Esophagus Muscularis | ICOSLG | 0.16 | 0.07 | lasso | 4 | 0.09 | 7.0e-06 | 8.7 | -7.9 | 3.4e-15 | 0.24 | 0.00 | 1.00 | TRUE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | ICOSLG | 0.23 | 0.02 | enet | 5 | 0.05 | 1.2e-03 | 8.7 | -9.3 | 1.2e-20 | 0.44 | 0.01 | 0.94 | TRUE |
| 6 | GTEx | Skin Sun Exposed Lower leg | ICOSLG | 0.21 | 0.08 | enet | 27 | 0.10 | 1.8e-08 | -5.4 | -6.7 | 1.7e-11 | 0.39 | 0.97 | 0.03 | TRUE |
| 7 | METSIM | Adipose | ICOSLG | 0.08 | 0.02 | bslmm | 488 | 0.04 | 3.8e-06 | -9.1 | -8.5 | 1.8e-17 | 0.51 | 0.00 | 1.00 | FALSE |
| 8 | NTR | Blood | ICOSLG | 0.05 | 0.01 | enet | 17 | 0.03 | 2.9e-10 | -9.1 | -6.7 | 2.4e-11 | 0.69 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ICOSLG | 0.07 | 0.02 | enet | 9 | 0.04 | 4.5e-04 | -2.9 | -7.9 | 3.7e-15 | 0.51 | 0.10 | 0.74 | TRUE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ICOSLG | 0.10 | 0.08 | blup | 68 | 0.10 | 5.9e-11 | -5.4 | -7.8 | 5.9e-15 | 0.35 | 0.93 | 0.06 | TRUE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ICOSLG | 0.09 | 0.06 | blup | 68 | 0.05 | 1.1e-06 | -2.2 | -5.5 | 2.9e-08 | 0.34 | 0.90 | 0.03 | TRUE |
| 12 | The Cancer Genome Atlas | Lung Adenocarcinoma | ICOSLG | 0.05 | 0.00 | blup | 68 | 0.02 | 2.4e-03 | 8.7 | -6.1 | 1.4e-09 | 0.42 | 0.03 | 0.58 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ICOSLG | 0.05 | 0.01 | enet | 12 | 0.02 | 9.7e-04 | -4.7 | -6.2 | 4.3e-10 | 0.45 | 0.05 | 0.18 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PDXK | 0.04 | 0.00 | blup | 74 | 0.01 | 2.4e-02 | 3.3 | 5.6 | 1.6e-08 | -0.04 | 0.00 | 0.07 | TRUE |
| 15 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | HSF2BP | 0.16 | -0.01 | blup | 62 | 0.02 | 4.7e-02 | 3.0 | 5.4 | 6.7e-08 | 0.07 | 0.01 | 0.17 | FALSE |