[Hub]/) : Traits : Blood Eosinophil Count : ← →

chr2:60,422,555-62,807,954

Best TWAS P=5.45e-17 · Best GWAS P=3.77e-17 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	KIAA1841	0.05	0.05	enet	15	0.06	1.2e-07	6.5	5.3	1.3e-07	0.82	0.25	0.75	FALSE
2	CommonMind	Brain Pre-frontal Cortex	XPO1	0.06	0.03	bslmm	313	0.03	1.4e-04	7.5	-6.8	8.5e-12	-0.83	0.09	0.91	FALSE
3	GTEx	Adipose Subcutaneous	RP11-493E12.2	0.05	0.02	lasso	4	0.03	1.3e-03	8.4	-7.9	2.7e-15	-0.98	0.02	0.97	FALSE
4	GTEx	Adrenal Gland	KIAA1841	0.13	0.01	enet	15	0.02	4.6e-02	-5.2	5.6	2.1e-08	0.47	0.07	0.16	FALSE
5	GTEx	Adrenal Gland	AC016747.3	0.26	0.23	enet	14	0.13	1.9e-05	-3.9	5.7	1.3e-08	0.49	0.90	0.03	FALSE
6	GTEx	Brain Cerebellar Hemisphere	KIAA1841	0.16	0.08	enet	10	0.09	2.7e-03	7.2	7.7	1.0e-14	0.72	0.13	0.58	FALSE
7	GTEx	Brain Cerebellum	RP11-493E12.2	0.30	0.01	enet	27	0.10	6.5e-04	6.5	-7.4	1.8e-13	-0.45	0.07	0.22	TRUE
8	GTEx	Brain Hippocampus	RP11-493E12.2	0.14	0.08	lasso	7	0.09	3.9e-03	5.1	-6.5	6.5e-11	-0.67	0.09	0.36	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	RP11-493E12.2	0.15	0.05	lasso	5	0.03	4.1e-02	7.2	-8.0	8.8e-16	-0.74	0.05	0.67	FALSE
10	GTEx	Cells Transformed fibroblasts	RP11-493E12.2	0.23	0.09	enet	25	0.09	1.9e-07	-5.0	-6.0	2.1e-09	-0.31	0.98	0.00	FALSE
11	GTEx	Colon Sigmoid	AHSA2	0.42	0.29	enet	17	0.43	1.1e-16	-3.7	5.2	2.1e-07	0.64	1.00	0.00	FALSE
12	GTEx	Esophagus Mucosa	AHSA2	0.23	0.12	enet	28	0.18	4.5e-12	-3.7	6.9	4.3e-12	0.65	0.97	0.03	FALSE
13	GTEx	Esophagus Muscularis	KIAA1841	0.06	0.10	enet	10	0.10	9.0e-07	7.5	7.3	2.2e-13	0.92	0.05	0.95	FALSE
14	GTEx	Esophagus Muscularis	RP11-493E12.2	0.05	0.09	lasso	3	0.06	2.0e-04	8.4	-8.4	5.4e-17	-1.00	0.02	0.98	TRUE
15	GTEx	Heart Atrial Appendage	AHSA2	0.24	0.19	enet	19	0.18	1.3e-08	-5.2	6.2	7.1e-10	0.68	0.88	0.12	FALSE
16	GTEx	Heart Atrial Appendage	AC016747.3	0.15	0.08	lasso	8	0.16	1.9e-07	-4.7	5.8	7.4e-09	0.78	0.59	0.41	FALSE
17	GTEx	Heart Left Ventricle	AC016747.3	0.08	0.00	enet	12	0.03	1.2e-02	7.0	6.5	9.0e-11	0.76	0.14	0.46	FALSE
18	GTEx	Muscle Skeletal	AHSA2	0.08	0.06	lasso	4	0.09	2.5e-09	-3.7	5.2	2.0e-07	0.78	0.18	0.82	FALSE
19	GTEx	Muscle Skeletal	RP11-493E12.2	0.05	0.01	lasso	4	0.01	8.2e-02	-5.0	-6.6	4.2e-11	-0.59	0.07	0.52	FALSE
20	GTEx	Nerve Tibial	KIAA1841	0.06	0.01	lasso	4	0.02	1.5e-02	5.1	7.8	5.0e-15	0.75	0.06	0.88	FALSE
21	GTEx	Nerve Tibial	RP11-493E12.2	0.05	0.06	lasso	6	0.04	7.0e-04	6.5	-6.7	3.0e-11	-0.93	0.08	0.91	FALSE
22	GTEx	Ovary	RP11-493E12.2	0.14	0.12	lasso	7	0.13	5.0e-04	7.6	-7.3	2.1e-13	-0.95	0.08	0.80	FALSE
23	GTEx	Pancreas	AC016747.3	0.10	0.08	enet	11	0.09	1.2e-04	5.2	5.5	4.5e-08	0.73	0.41	0.54	TRUE
24	GTEx	Pituitary	AC016747.3	0.23	0.19	enet	12	0.20	1.0e-05	6.8	6.8	1.5e-11	0.84	0.14	0.82	FALSE
25	GTEx	Prostate	RP11-493E12.2	0.15	0.16	lasso	4	0.09	3.4e-03	7.5	-5.7	9.2e-09	-0.83	0.07	0.77	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	AHSA2	0.25	0.23	enet	13	0.28	2.1e-15	6.6	6.9	4.8e-12	0.77	0.91	0.09	FALSE
27	GTEx	Skin Sun Exposed Lower leg	AHSA2	0.16	0.14	lasso	8	0.23	1.4e-18	7.0	7.0	2.0e-12	0.78	0.72	0.28	TRUE
28	GTEx	Skin Sun Exposed Lower leg	AC016747.3	0.06	0.06	enet	6	0.04	5.4e-04	-6.0	5.6	2.5e-08	0.50	0.91	0.04	FALSE
29	GTEx	Stomach	AHSA2	0.22	0.17	enet	21	0.24	1.0e-11	-3.8	5.1	3.0e-07	0.70	0.97	0.03	FALSE
30	GTEx	Testis	REL	0.16	0.13	enet	9	0.10	5.4e-05	-5.4	6.9	5.5e-12	0.31	0.62	0.02	FALSE
31	GTEx	Testis	RP11-373L24.1	0.12	0.08	enet	5	0.04	4.5e-03	-5.4	5.5	5.2e-08	0.16	0.19	0.04	FALSE
32	GTEx	Thyroid	KIAA1841	0.06	0.01	enet	18	0.02	1.0e-02	7.2	7.9	3.1e-15	0.57	0.26	0.34	FALSE
33	GTEx	Thyroid	RP11-493E12.2	0.05	0.06	lasso	5	0.05	9.3e-05	-4.7	-5.2	1.6e-07	-0.66	0.58	0.27	FALSE
34	GTEx	Uterus	RP11-493E12.2	0.16	0.02	lasso	5	0.05	3.6e-02	6.0	-6.6	5.1e-11	-0.52	0.05	0.32	FALSE
35	GTEx	Vagina	AHSA2	0.32	0.20	enet	33	0.34	1.3e-08	4.0	5.4	7.8e-08	0.71	0.10	0.88	FALSE
36	GTEx	Whole Blood	AHSA2	0.19	0.27	lasso	9	0.32	3.7e-30	-5.2	5.2	1.8e-07	0.68	1.00	0.00	FALSE
37	GTEx	Whole Blood	AC016747.3	0.07	0.08	lasso	6	0.08	3.9e-08	4.4	5.1	3.1e-07	0.75	0.73	0.27	FALSE
38	GTEx	Whole Blood	RP11-493E12.2	0.04	0.02	lasso	6	0.01	1.8e-02	6.8	-7.2	6.3e-13	-0.68	0.24	0.61	FALSE
39	METSIM	Adipose	RP11-493E12.1	0.03	0.02	bslmm	316	0.01	3.2e-03	5.2	-5.7	1.5e-08	-0.47	0.59	0.05	FALSE
40	NTR	Blood	USP34	0.02	0.01	lasso	5	0.01	7.3e-04	6.5	-7.0	2.0e-12	-0.54	0.22	0.27	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	XPO1	0.03	0.02	blup	310	0.02	3.4e-03	7.5	-7.6	3.9e-14	-0.88	0.05	0.89	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	CCT4	0.05	0.00	bslmm	291	0.01	7.7e-03	-1.7	5.7	1.4e-08	0.63	0.05	0.57	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	PUS10	0.04	0.01	lasso	3	0.03	4.9e-05	-2.8	-6.3	2.7e-10	-0.04	0.22	0.02	TRUE
44	YFS	Blood	AHSA2	0.50	0.46	enet	32	0.62	3.1e-265	-3.9	6.3	2.7e-10	0.73	1.00	0.00	FALSE
45	YFS	Blood	PEX13	0.01	0.00	blup	334	0.01	6.7e-03	3.7	-5.8	8.5e-09	-0.68	0.08	0.53	TRUE
46	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AHSA2	0.09	0.10	blup	38	0.14	1.0e-11	-6.0	5.2	2.3e-07	0.72	0.42	0.58	FALSE
47	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	AHSA2	0.11	0.12	enet	6	0.11	4.9e-06	-4.7	5.4	5.2e-08	0.72	0.06	0.92	FALSE
48	The Cancer Genome Atlas	Esophageal Carcinoma	C2orf74	0.17	0.30	lasso	11	0.32	4.7e-11	-5.2	-5.3	1.2e-07	-0.62	0.19	0.81	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AHSA2	0.06	0.05	blup	39	0.06	8.9e-08	6.5	6.2	4.9e-10	0.81	0.02	0.98	FALSE
50	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AHSA2	0.13	0.05	enet	8	0.09	5.8e-06	-5.2	5.2	1.6e-07	0.72	0.03	0.94	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	AHSA2	0.09	0.12	lasso	5	0.16	7.6e-19	-6.0	5.9	2.8e-09	0.76	0.50	0.50	FALSE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KIAA1841	0.05	0.02	blup	61	0.02	4.5e-03	6.5	5.5	4.5e-08	0.45	0.01	0.81	FALSE
53	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	AHSA2	0.16	0.20	blup	39	0.22	2.0e-09	-3.9	6.1	8.1e-10	0.75	0.26	0.74	FALSE
54	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AHSA2	0.20	0.11	blup	39	0.22	3.5e-09	-4.2	5.1	2.9e-07	0.77	0.04	0.96	FALSE
55	The Cancer Genome Atlas	Rectum Adenocarcinoma	AHSA2	0.12	0.13	lasso	2	0.07	1.1e-02	6.5	6.7	1.8e-11	0.68	0.01	0.42	TRUE
56	The Cancer Genome Atlas	Thyroid Carcinoma	AHSA2	0.27	0.32	enet	11	0.34	1.3e-33	-6.0	5.3	1.0e-07	0.71	0.85	0.15	FALSE