Hub : Genes

CCT4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 ROSMAP Brain Pre-frontal Cortex 0.0475 0.0242 0.00280 0.002 0.010 0.002 0.013 0.001 1.4e-01 0.01500 1.7e-01 7.7e-03 2.2e-01
2 YFS Blood 0.0327 0.0120 0.00026 0.021 0.011 0.016 0.012 0.020 1.1e-07 0.00014 4.0e-06 4.2e-05 3.7e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.9 1.5 2.8 -1.7 -0.4
Bipolar Disorder or Schizophrenia 0.2 0.6 0.8 -0.9 -0.6
Depressed Affect (Nagel 2018) 1.3 2.6 4.2 -2.1 1.0
Depression (Nagel 2018) 0.2 0.3 0.6 -0.1 0.8
Intelligence (Savage-Jansen 2018) 1.4 4.2 4.4 -2.1 -2.0
Neuroticism (Nagel 2018) 1.6 3.8 5.6 -2.4 1.4
Schizophrenia (2018) 0.1 0.1 0.2 0.2 -0.4
Schizophrenia vs Biploar Disorder 0.0 0.0 0.0 0.1 -0.1
Worry (Nagel 2018) 2.4 5.0 9.3 -3.0 0.9
Alzheimer’s Disease (in mother) 0.0 0.0 0.0 0.1 0.2
Alzheimer’s Disease (in father) 4.4 4.8 8.4 -2.9 -1.1
Alzheimer’s Disease (including proxy) 0.7 1.0 2.0 -1.4 -0.1
Crohns Disease (2017) 1.0 2.3 3.6 -1.9 1.0
Irritable Bowel Disease (IBD) 2.5 5.9 10.9 -3.3 1.0
Ulcerative Colitis (UC) 2.4 4.5 8.9 -3.0 -0.0
Major Depression (MDD) 0.5 0.6 0.8 0.9 0.7
Reaction Time 0.5 1.0 2.0 1.4 0.0
Verbal and Numeric Reasoning (VNR) 3.5 8.4 10.7 -3.3 -2.5
Breast Cancer 0.4 0.9 1.7 1.3 0.3
Ovarian Cancer 0.6 0.8 1.1 1.1 0.7
Prostate Cancer 0.1 0.1 0.1 -0.4 0.0
Age at First Birth 4.0 5.8 10.6 -3.2 -1.0
Bipolar Disorder (2011) 0.8 0.7 1.3 -0.5 -1.1
Body Mass Index (BMI) (2010) 1.2 1.6 2.0 1.4 1.1
Coronary Artery Disease (CAD) 0.3 0.4 0.6 0.8 0.3
Crohns Disease (2012) 1.2 1.9 2.1 -1.5 1.3
Mean Putamen Volume 0.5 0.5 0.7 -0.6 -0.9
Fasting Glucose 1.1 1.4 1.5 1.1 -1.2
HbA1C 2.4 2.6 3.4 1.9 1.4
HDL Cholesterol 0.2 0.3 0.3 0.6 0.5
LDL Cholesterol 0.4 0.6 0.7 0.7 0.9
Lupus 0.9 1.4 2.4 -0.7 1.5
Neuroticism (2016) 1.8 2.5 5.1 -2.2 0.0
Primary Biliary Cirrhosis 0.0 0.1 0.1 -0.3 0.1
Rheumatoid Arthritis 3.1 4.3 7.5 2.7 -1.0
Schizophrenia (2014) 0.1 0.1 0.2 -0.3 -0.4
Triglycerides 0.5 0.8 1.2 1.1 -0.6
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.1 -0.2 0.1
Ulcerative Colitis 3.4 5.0 8.4 -2.9 1.2
Blood Eosinophil Count 2.1 16.2 32.1 5.7 0.6
Blood Platelet Count 0.6 7.0 13.9 3.7 -0.3
Blood Red Count 0.1 1.0 1.3 0.9 1.2
Blood White Count 2.9 21.5 41.9 6.5 1.1
Heel T-Score 0.7 5.6 5.8 2.3 -2.4
BMI 0.1 0.8 1.2 0.6 1.1
Height 0.2 3.9 5.3 -1.6 2.3
Waist Hip Ratio (WHR) 0.1 0.4 0.4 0.6 0.5
Systolic Blood Pressure 1.0 4.9 9.2 3.0 -0.8
Smoking Status 2.3 5.4 8.9 3.0 1.4
Allergy or Eczema 2.2 5.8 11.6 -3.4 -0.3
Cardiovascular Disease 0.8 2.7 5.3 2.3 0.4
Hypothyroidism (self reported) 0.7 1.6 2.2 -1.0 1.5
Respiratory disease 0.5 1.1 2.1 -1.4 0.5
Type 2 Diabetes (T2D) (2018) 1.1 2.1 4.2 2.0 -0.2
Lung FEV1/FVC ratio 1.2 6.3 12.5 -3.5 0.3
Lung FVC 1.2 6.3 11.9 3.5 -0.8
Neuroticism 1.3 3.2 5.2 -2.3 1.1
Chronotype (morning person) 2.1 4.9 5.1 -2.3 2.2
Hair Pigment 0.0 1.3 2.3 0.5 1.5
Tanning 0.2 2.4 4.5 -2.1 0.7
Hand grip strength (left) 1.0 2.7 5.4 -0.3 2.3
Number of treatments/medications taken 0.6 1.0 1.5 0.7 -1.2
Average weekly spirits intake 0.3 0.4 0.7 0.2 -0.9
Sensitivity / hurt feelings 0.1 0.1 0.1 -0.4 -0.2
Frequency of depressed mood in last 2 weeks 0.9 1.2 1.6 -1.3 0.9
Hearing difficulty/problems: Yes 0.5 0.8 1.2 -1.1 -0.6
Relative age of first facial hair 1.0 2.0 3.3 -1.8 0.8
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.3 -0.5 0.2
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.2 0.4 -0.4
Ever had hysterectomy (womb removed) 1.0 1.2 1.2 -1.0 -1.1
Systolic blood pressure, automated reading 0.2 0.5 0.9 1.0 -0.4
Eye problems/disorders: Diabetes related eye disease 3.6 4.0 7.9 2.8 -0.3
Angina 0.5 0.7 1.4 1.2 -0.2
Medication for hormone replacement therapy 1.6 1.8 2.4 -1.1 -1.5
Vitamin and mineral supplements 1.1 1.4 2.9 -1.7 -0.1
Supplements: Zinc 0.1 0.1 0.1 -0.3 -0.4
Medication: Co-codamol 0.1 0.1 0.1 0.3 -0.2
Medication: Metformin 0.7 1.0 1.9 0.3 -1.4
Diabetes (father) 1.0 1.3 1.5 -1.2 1.0
Diabetes (mother) 2.0 2.6 4.0 -2.0 -1.1
Severe depression (siblings) 0.4 0.5 1.0 -0.0 1.0
Pack years adult smoking proportion 1.3 1.9 3.2 1.8 0.8
Impedance of leg (right) 0.1 0.4 0.6 0.7 0.4
Leg fat-free mass (left) 0.3 1.5 2.7 -1.6 -0.6
Trunk fat percentage 0.2 0.8 1.6 0.3 -1.2
Hand grip strength (right) 0.4 1.1 2.2 0.3 1.5
Townsend deprivation index at recruitment 0.7 1.0 1.9 1.4 -0.3
Current tobacco smoking 1.2 2.0 3.9 2.0 0.2
Average weekly fortified wine intake 1.3 1.5 3.0 0.1 -1.7
Maternal smoking around birth 0.5 0.7 0.7 0.8 -0.9
Fed-up feelings 1.1 2.0 3.7 -1.9 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.0 -0.1 -1.0
Relative age voice broke 0.1 0.1 0.1 0.3 -0.3
Taking other prescription medications 0.1 0.1 0.2 -0.4 0.0
Age when periods started (menarche) 2.1 5.1 9.1 3.0 -1.0
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 1.1 -0.9 1.1
Heel bone mineral density (BMD) T-score, automated (left) 1.3 3.0 4.2 2.1 -1.3
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.1 0.4 0.4
Qualifications: CSEs or equivalent 2.4 3.2 4.1 1.5 2.0
Serious illness, injury or assault to yourself 0.6 0.8 1.3 -1.2 -0.4
High blood pressure 0.7 1.8 3.6 1.9 0.3
Hayfever, allergic rhinitis or eczema 2.4 5.3 10.5 -3.2 0.2
Multivitamins +/- minerals 1.3 1.6 1.9 1.4 -1.1
Stomach or abdominal pain in last month 0.4 0.5 0.8 0.6 -0.9
Supplements: Glucosamine 2.5 3.3 5.2 2.3 -1.1
Diverticular disease/diverticulitis (self-reported) 1.3 1.6 3.0 1.7 0.5
Medication: Atenolol 3.0 3.7 7.3 2.7 -0.3
Medication: Levothyroxine sodium 0.2 0.3 0.6 -0.2 -0.8
Sitting height 0.2 1.6 2.0 -1.4 1.1
Chronic bronchitis/emphysema (father) 1.2 1.4 1.7 1.0 -1.3
High blood pressure (mother) 1.4 2.0 2.8 -1.1 -1.7
Body mass index (BMI) 0.1 0.4 0.6 0.3 -0.8
Impedance of leg (left) 0.1 0.3 0.5 0.7 0.2
Leg predicted mass (left) 0.3 1.5 2.6 -1.6 -0.6
Trunk fat mass 0.1 0.4 0.7 -0.2 -0.8
Waist circumference 0.1 0.4 0.7 0.3 -0.9
Number of incorrect matches in round 0.0 0.0 0.0 0.0 -0.0
Past tobacco smoking 0.4 0.8 1.4 -1.2 -0.4
Alcohol usually taken with meals 0.4 0.7 1.0 1.0 -0.6
Nervous feelings 1.2 2.2 4.2 -2.1 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.6 0.2 0.8
Hearing difficulty/problems with background noise 2.0 3.2 6.5 -2.5 -0.2
Hair/balding pattern: Pattern 2 1.8 2.2 4.4 2.1 -0.2
Had menopause 0.7 0.9 1.6 -1.3 -0.4
Had other major operations 0.6 0.7 1.4 0.0 -1.2
Forced vital capacity (FVC) 0.7 2.6 4.3 2.1 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.4 3.6 1.9 -1.8
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.2 0.5 -0.2
Qualifications: None of the above 0.7 1.5 3.0 1.7 -0.2
Financial difficulties in last 2 years 0.2 0.2 0.4 0.6 -0.3
Mouth/teeth dental problems 0.1 0.2 0.2 -0.5 -0.4
Heart attack 1.3 1.6 3.3 1.8 0.1
Allergy 2.6 5.9 11.8 3.4 -0.1
Pain all over the body in last month 1.3 1.4 2.8 0.2 -1.7
Diabetes (self-reported) 0.5 0.8 1.5 1.2 0.2
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.0 -1.4 0.5
Medication: Ramipril 0.3 0.4 0.8 0.9 -0.2
Medication: Simvastatin 4.9 7.2 13.3 3.6 -1.0
Fluid intelligence score 4.4 9.1 11.3 -3.4 -2.6
Illnesses of siblings 1.2 1.7 2.7 -0.9 1.6
Neuroticism score 2.4 5.0 9.9 -3.1 0.4
Weight 0.1 0.5 0.7 -0.8 -0.5
Impedance of arm (right) 0.1 0.3 0.5 0.7 -0.2
Arm fat percentage (right) 0.2 0.9 1.5 0.5 -1.2
Trunk fat-free mass 0.3 1.6 2.8 -1.7 0.6
Hip circumference 0.1 0.4 0.4 -0.6 -0.6
Time employed in main current job 2.1 2.4 4.6 -2.1 -0.4
Alcohol intake versus 10 years previously 0.7 1.0 1.9 1.4 -0.2
Father’s age at death 1.2 1.6 3.3 -1.8 0.1
Worrier / anxious feelings 1.7 3.3 5.9 -2.4 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.0 0.0 0.2 0.0
Falls in the last year 0.6 0.9 1.6 1.3 -0.4
Hair/balding pattern: Pattern 3 1.1 1.7 3.1 -1.8 0.5
Number of live births 1.2 1.6 2.2 1.5 -1.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.1 0.1 -1.1
Pulse rate 0.2 0.3 0.5 -0.7 -0.3
Happiness 0.6 0.8 1.5 -1.2 -0.1
Noisy workplace 1.3 1.7 2.9 1.7 -0.7
Qualifications: A levels/AS levels or equivalent 1.2 2.6 4.7 -2.2 -0.7
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.7 3.0 -0.6 -1.7
Mouth/teeth dental problems: Dentures 0.5 0.9 1.0 0.9 1.0
Asthma 0.5 1.0 1.1 -1.0 1.0
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.3 -0.8 -1.1
Medication: Cholesterol lowering 1.1 1.6 3.2 1.8 -0.3
Depression (self-reported) 1.0 1.2 2.2 -1.5 0.5
Medication: Lansoprazole 0.3 0.3 0.6 0.0 -0.8
Prospective memory result 0.3 0.3 0.6 0.2 0.8
Lung cancer (father) 0.4 0.5 0.9 0.3 -0.9
Illnesses of mother 0.1 0.1 0.3 0.1 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.3 -0.4 -0.6
Pulse wave Arterial Stiffness index 0.1 0.1 0.1 0.1 0.4
Impedance of arm (left) 0.0 0.1 0.1 0.4 0.1
Arm fat mass (right) 0.0 0.2 0.4 -0.1 -0.6
Trunk predicted mass 0.3 1.7 2.9 -1.7 0.6
Standing height 0.4 4.2 7.3 -2.7 1.0
Length of working week for main job 0.4 0.4 0.7 -0.9 0.4
Exposure to tobacco smoke at home 0.0 0.0 0.0 -0.0 0.1
Breastfed as a baby 2.6 3.3 4.8 -1.3 2.2
Tense / ‘highly strung’ 1.6 2.7 5.1 -2.3 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 0.7 -0.8 -0.0
Hair/balding pattern: Pattern 4 1.9 4.6 8.2 2.9 1.0
Birth weight of first child 1.5 2.7 3.5 -1.9 -1.3
Peak expiratory flow (PEF) 1.2 2.7 4.7 -2.2 0.8
Pulse wave reflection index 0.7 0.8 1.5 0.4 -1.2
Ever highly irritable/argumentative for 2 days 1.4 1.6 1.9 1.4 1.2
Loud music exposure frequency 0.5 0.6 0.8 -0.9 0.6
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.9 -1.0 -0.3
Mouth/teeth dental problems: Bleeding gums 0.0 0.0 0.1 0.2 -0.2
Blood clot in the leg (DVT) 0.6 0.8 1.3 -1.2 -0.5
Medication: Paracetamol 0.7 1.2 2.1 0.5 -1.4
Headache pain in last month 2.3 4.0 8.0 0.3 -2.8
Medication for cholesterol, blood pressure or diabetes 1.1 1.9 3.7 -1.9 -0.1
Glaucoma (self-reported) 1.1 1.3 1.9 1.4 -0.8
Gout (self-reported) 1.5 2.1 4.0 2.0 0.3
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.7 -0.8 0.4
Medication: Amlodipine 1.8 2.6 5.1 2.3 0.0
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.4 -0.6 0.4
Birth weight 0.1 0.1 0.2 -0.4 -0.2
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.4 0.4 -0.6
High blood pressure (siblings) 1.0 1.4 1.8 1.0 -1.3
Forced vital capacity (FVC), Best measure 0.3 1.2 1.7 1.3 -0.8
Body fat percentage 0.2 0.8 1.3 0.5 -1.1
Leg fat percentage (right) 0.1 0.4 0.5 0.7 -0.5
Arm fat-free mass (right) 0.2 1.1 2.1 -1.4 -0.3
Exposure to tobacco smoke outside home 0.6 0.8 1.6 1.3 -0.3
Comparative body size at age 10 0.4 1.1 2.0 1.4 -0.3
Number of full brothers 1.1 1.4 2.9 -0.1 -1.7
Worry too long after embarrassment 3.3 5.6 10.6 -3.3 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 3.1 4.1 7.8 -0.6 2.8
Wheeze or whistling in the chest in last year 0.2 0.4 0.8 0.9 -0.1
Number of children fathered 1.7 1.9 2.9 -1.7 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 1.8 -1.4 -0.1
Age at first live birth 1.9 3.3 5.2 -2.3 1.2
Pulse wave peak to peak time 0.1 0.1 0.2 -0.4 -0.3
Health satisfaction 0.6 0.8 1.4 0.3 -1.2
Shortness of breath walking on level ground 2.5 3.0 5.6 2.4 0.6
Qualifications: College or University degree 1.4 4.5 8.9 -3.0 -0.0
Eye problems/disorders: None of the above 0.2 0.2 0.4 -0.3 0.6
Mouth/teeth dental problems: Loose teeth 0.8 1.0 1.6 -0.6 -1.2
Emphysema/chronic bronchitis 0.0 0.0 0.0 -0.1 -0.2
Medication for pain relief, constipation, heartburn 0.9 1.5 2.4 -0.8 1.5
Neck or shoulder pain in last month 3.5 4.9 9.8 3.1 -0.1
Medication: Blood pressure 0.6 1.1 2.0 1.4 0.3
Angina (self-reported) 0.7 1.0 1.8 1.4 -0.3
Migraine (self-reported) 3.6 4.5 5.4 1.9 -2.3
Medication: Ibuprofen 1.1 1.3 1.5 -1.0 -1.2
Medication: Allopurinol 0.7 0.9 1.2 1.1 0.8
Medication: Omeprazole 0.5 0.6 1.1 -0.2 1.0
Medication: Seretide 50 evohaler 1.0 1.1 2.3 1.5 0.1
Mean time to correctly identify matches 0.5 1.0 2.0 1.4 -0.3
Heart disease (mother) 1.3 1.6 2.8 1.7 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.4 0.1 0.7
Whole body fat mass 0.1 0.3 0.7 -0.0 -0.8
Leg fat mass (right) 0.1 0.2 0.4 -0.1 -0.6
Arm predicted mass (right) 0.2 1.1 2.0 -1.4 -0.3
Pulse rate, automated reading 0.0 0.2 0.2 -0.5 0.3
Alcohol intake frequency. 0.3 0.6 0.9 -0.9 0.6
Comparative height size at age 10 0.3 1.8 3.4 -1.9 0.5
Number of full sisters 0.0 0.1 0.1 -0.2 0.2
Suffer from ‘nerves’ 1.1 1.6 3.2 -1.8 -0.2
Overall health rating 0.0 0.1 0.1 -0.2 -0.3
Chest pain or discomfort 1.5 2.2 2.9 -1.2 -1.7
Had major operations 0.3 0.3 0.5 0.3 -0.7
Age at last live birth 1.5 2.1 3.6 -1.9 -0.8
Family relationship satisfaction 0.7 0.9 1.7 -0.2 1.3
Leg pain on walking 0.2 0.2 0.5 0.1 -0.7
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.2 3.4 1.0 -1.9
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.7 1.3 -0.2
Illness, injury, bereavement, stress in last 2 years 2.5 3.1 4.1 1.4 2.0
Medication: Aspirin 0.7 1.0 1.5 0.7 -1.2
Supplements: Vitamin C 2.2 2.7 5.3 -0.1 2.3
Knee pain experienced in last month 1.7 2.7 4.4 2.1 -0.9
Hypertension (Self-reported) 0.7 1.8 3.4 1.8 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 1.7 -1.3 0.2
Illnesses of father: Heart disease 1.2 1.7 2.6 1.6 0.9
Illnesses of siblings: Diabetes 0.8 1.0 2.0 -1.4 -0.1
Smoking status: Previous 0.2 0.3 0.6 0.8 0.1
Forced expiratory volume in 1-second (FEV1), predicted 2.1 4.3 6.8 -2.6 1.4
Whole body fat-free mass 0.2 1.4 2.8 -1.7 0.0
Leg fat-free mass (right) 0.3 1.7 2.9 -1.7 -0.7
Arm fat percentage (left) 0.2 0.7 1.2 0.5 -1.1
Average weekly red wine intake 0.7 1.1 1.7 -0.7 -1.3
Handedness (chirality/laterality): Left-handed 0.7 0.9 1.3 -0.6 1.1
Mood swings 0.6 1.1 1.1 -1.0 1.1
Loneliness, isolation 0.0 0.0 0.1 -0.3 -0.1
Long-standing illness, disability or infirmity 0.8 1.3 2.5 -0.1 -1.6
Ever had bowel cancer screening 0.3 0.4 0.6 -0.8 -0.4
Diabetes diagnosed by doctor 0.8 1.3 2.5 1.6 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.5 -0.5 0.7
Friendships satisfaction 0.8 1.1 1.4 1.2 0.9
Qualifications: nursing, teaching 1.6 2.5 4.5 -2.1 0.7
Commuting to job workplace: Walk 1.0 1.1 1.8 1.3 0.7
Eye problems/disorders: Cataract 0.1 0.2 0.2 -0.4 0.4
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 1.7 -0.7 -1.3
Medication for cholesterol 2.5 3.7 7.2 -2.7 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 2.5 -0.8 -1.6
Back pain experienced in last month 0.6 0.9 1.4 0.7 -1.2
Mineral and other dietary supplements 1.4 1.9 3.0 -1.7 0.9
Breast cancer (self-reported) 1.0 1.2 1.9 -0.7 1.4
Asthma (self-reported) 0.5 1.0 1.4 -1.2 0.8
Osteoporosis (self-reported) 0.7 0.8 0.9 -0.9 -1.0
Osteoarthritis (self-reported) 0.1 0.1 0.3 0.5 -0.1
Medication: Aspirin 0.7 0.9 1.5 0.5 -1.2
Medication: Gliclazide 0.3 0.4 0.6 0.4 0.8
Illnesses of father: None of the above (group 1) 0.2 0.2 0.5 0.1 0.7
Smoking status: Current 1.3 2.0 3.9 2.0 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.6 2.1 1.5 -1.0
Whole body water mass 0.2 1.2 2.4 -1.6 -0.1
Leg predicted mass (right) 0.3 1.6 2.9 -1.7 -0.6
Arm fat mass (left) 0.1 0.4 0.7 -0.0 -0.8
Number of self-reported non-cancer illnesses 0.3 0.5 0.9 -1.0 -0.4
Average weekly champagne plus white wine intake 0.2 0.2 0.3 -0.5 0.5
Miserableness 0.4 0.8 1.5 -1.2 0.1
Guilty feelings 1.0 1.5 2.5 -1.6 0.7
Wears glasses or contact lenses 0.2 0.3 0.4 0.3 0.7
Ever taken oral contraceptive pill 1.0 1.2 2.2 1.5 0.3
Hearing aid user 1.0 1.2 1.9 -1.4 0.6
Mother’s age at death 0.3 0.4 0.6 -0.8 0.3
Financial situation satisfaction 1.3 1.6 2.7 1.6 -0.7
Tinnitus: Yes, now most or all of the time 1.5 1.7 3.2 -0.4 1.8
Commuting to job workplace: Public transport 1.2 1.4 2.4 -0.7 -1.6
Eye problems/disorders: Glaucoma 4.8 5.7 8.2 2.9 -1.8
Medication: Blood pressure 4.1 7.9 14.1 3.8 1.3
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.8 -0.0 -0.9
Supplements: Fish oil (including cod liver oil) 1.1 1.5 2.5 1.6 -0.7
High cholesterol (Self-reported) 3.7 6.6 13.2 3.6 -0.3
Medication: Bendroflumethiazide 0.7 1.1 2.2 1.5 -0.1
Medication: Paracetamol 0.8 1.3 2.3 0.5 -1.5
Medication: Lisinopril 1.0 1.3 2.6 1.6 0.2
Medication: Atorvastatin 0.1 0.1 0.2 0.3 -0.4
Illnesses of father: High blood pressure 0.9 1.1 1.8 1.4 0.6
Alcohol drinker status: Never 1.5 1.8 3.2 -0.7 -1.8
Ever smoked 0.1 0.3 0.4 0.3 0.7
Basal metabolic rate 0.2 1.0 2.0 -1.4 -0.3
Leg fat percentage (left) 0.1 0.4 0.6 0.8 -0.5
Arm fat-free mass (left) 0.2 1.0 1.8 -1.4 -0.5
Number of operations (self-reported) 0.3 0.5 0.7 -0.9 -0.6
Average weekly beer plus cider intake 0.1 0.1 0.2 0.5 0.2
Irritability 0.5 0.9 1.7 -1.3 -0.1
Risk taking 0.2 0.3 0.6 -0.8 -0.1
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.3 -0.3 0.6
Fractured/broken bones in last 5 years 1.5 1.9 3.4 0.6 -1.8
Age started oral contraceptive pill 0.0 0.0 0.1 -0.1 -0.3
Diastolic blood pressure, automated reading 0.6 1.9 2.0 1.4 -1.3
Ever depressed for a whole week 0.4 0.5 0.8 0.5 0.9
Unable to work because of sickness or disability 1.3 1.7 3.2 1.8 -0.5
Commuting to job workplace: Cycle 0.8 1.0 2.0 -0.2 1.4
Myopia 0.4 0.6 0.7 -0.8 -0.8
Vascular/heart problems diagnosed by doctor 1.2 3.3 6.3 -2.5 -0.5
Cholesterol lowering medication 5.0 7.4 14.5 3.8 0.5
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 0.6 0.8 0.6
Pain experienced in last month 1.8 3.0 3.1 -1.8 1.7
Supplements: Calcium 0.0 0.0 0.0 0.1 -0.2
Basal cell carcinoma (self-reported) 1.0 1.2 2.2 1.5 -0.5
Heart attack/myocardial infarction (self-reported) 1.2 1.6 3.1 1.8 0.2
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 2.6 -1.6 0.2
Heart disease (siblings) 1.1 1.3 1.5 1.1 1.2
Alcohol drinker status: Previous 0.5 0.6 0.8 0.6 0.9
Pack years of smoking 1.2 1.8 3.0 1.7 0.7
Impedance of whole body 0.0 0.1 0.2 0.4 -0.3
Leg fat mass (left) 0.1 0.3 0.6 -0.1 -0.8
Arm predicted mass (left) 0.2 1.0 1.3 -1.2 -0.8