Best TWAS P=1.68e-12 · Best GWAS P=2.75e-12 conditioned to 5.94e-11
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ZNF638 | 0.06 | 0.01 | bslmm | 559 | 0.02 | 1.8e-03 | -3.2 | -5.7 | 1.6e-08 | -0.21 | 0.33 | 0.03 | FALSE |
2 | GTEx | Esophagus Mucosa | NAGK | 0.53 | 0.34 | lasso | 8 | 0.51 | 1.7e-38 | -4.9 | 6.5 | 7.1e-11 | 0.06 | 0.06 | 0.94 | FALSE |
3 | GTEx | Esophagus Mucosa | MCEE | 0.14 | 0.07 | lasso | 7 | 0.06 | 1.0e-04 | -6.7 | 6.5 | 5.6e-11 | 0.11 | 0.00 | 1.00 | FALSE |
4 | GTEx | Nerve Tibial | NAGK | 0.13 | 0.10 | lasso | 4 | 0.08 | 4.7e-06 | -6.8 | 6.9 | 6.0e-12 | 0.06 | 0.00 | 1.00 | FALSE |
5 | GTEx | Spleen | NAGK | 0.38 | 0.14 | lasso | 11 | 0.14 | 1.7e-04 | -5.5 | 6.3 | 2.3e-10 | 0.06 | 0.01 | 0.93 | FALSE |
6 | GTEx | Spleen | PAIP2B | 0.36 | -0.01 | enet | 28 | 0.07 | 7.4e-03 | 2.7 | 5.3 | 1.5e-07 | -0.01 | 0.05 | 0.44 | FALSE |
7 | METSIM | Adipose | NAGK | 0.15 | 0.04 | enet | 30 | 0.11 | 2.5e-16 | -4.9 | 7.1 | 1.7e-12 | 0.06 | 0.13 | 0.87 | TRUE |
8 | YFS | Blood | NAGK | 0.43 | 0.45 | enet | 15 | 0.49 | 4.3e-186 | -4.9 | 5.6 | 2.6e-08 | 0.05 | 0.99 | 0.01 | FALSE |
9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NAGK | 0.06 | 0.02 | blup | 54 | 0.04 | 2.0e-04 | -6.2 | 5.4 | 5.9e-08 | 0.09 | 0.02 | 0.85 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NAGK | 0.03 | 0.04 | lasso | 5 | 0.04 | 4.2e-08 | -6.7 | 6.8 | 1.3e-11 | 0.08 | 0.00 | 1.00 | FALSE |
11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NAGK | 0.19 | 0.12 | blup | 55 | 0.16 | 1.6e-17 | -6.2 | 6.8 | 1.4e-11 | 0.07 | 0.03 | 0.97 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NAGK | 0.06 | 0.03 | blup | 55 | 0.06 | 4.6e-07 | -6.1 | 6.7 | 2.0e-11 | 0.08 | 0.01 | 0.99 | FALSE |
13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NAGK | 0.06 | 0.03 | blup | 55 | 0.05 | 2.2e-06 | -6.2 | 6.7 | 2.5e-11 | 0.08 | 0.01 | 0.99 | FALSE |
14 | The Cancer Genome Atlas | Lung Adenocarcinoma | NAGK | 0.06 | 0.05 | blup | 55 | 0.05 | 7.8e-07 | -4.9 | 5.4 | 5.8e-08 | 0.03 | 0.54 | 0.45 | FALSE |
15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NAGK | 0.15 | 0.09 | blup | 55 | 0.11 | 1.1e-12 | -6.4 | 6.7 | 2.8e-11 | 0.05 | 0.01 | 0.99 | FALSE |
16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | OR7E91P | 0.05 | 0.02 | enet | 12 | 0.05 | 4.5e-06 | -3.4 | 5.7 | 1.2e-08 | 0.10 | 0.02 | 0.93 | FALSE |
17 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | NAGK | 0.05 | 0.05 | lasso | 1 | 0.02 | 2.6e-02 | -6.2 | 6.2 | 5.0e-10 | 0.06 | 0.03 | 0.75 | FALSE |
18 | The Cancer Genome Atlas | Thyroid Carcinoma | NAGK | 0.11 | 0.06 | lasso | 3 | 0.05 | 6.2e-06 | -4.9 | 5.4 | 5.9e-08 | 0.05 | 0.64 | 0.13 | FALSE |