Hub : Genes

OR7E91P

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Lung Squamous Cell Carcinoma	0.0493	0.0242	1.1e-04	0.021	0.043	0.047	NA	0.043	1.8e-03	9.7e-06	4.5e-06	NA	1.1e-05
2	TCGA	Stomach Adenocarcinoma	0.1240	0.0630	2.8e-03	0.005	0.021	0.000	NA	0.017	1.4e-01	1.1e-02	3.1e-01	NA	2.0e-02
3	TCGA	Thyroid Carcinoma	0.1750	0.0610	2.9e-06	0.076	0.072	0.068	NA	0.074	7.4e-08	1.7e-07	3.6e-07	NA	1.1e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.1	0.2	0.4	-0.4	0.0
Bipolar Disorder or Schizophrenia	0.5	1.2	1.9	1.3	-0.4	-1.4
Depressed Affect (Nagel 2018)	0.1	0.3	0.5	0.6	0.7	0.0
Depression (Nagel 2018)	0.2	0.4	0.6	-0.7	-0.3	-0.7
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.3	1.5	-0.4	-1.8
Neuroticism (Nagel 2018)	0.5	1.2	2.2	1.5	1.0	-0.7
Schizophrenia (2018)	0.1	0.2	0.5	0.7	0.4	0.1
Schizophrenia vs Biploar Disorder	1.3	1.7	4.0	-2.0	-1.0	0.0
Worry (Nagel 2018)	0.3	0.6	1.6	0.5	-0.1	-1.2
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	0.2	-0.4	-1.0
Alzheimer’s Disease (in father)	0.4	0.4	1.2	-1.1	0.1	0.3
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	-0.8	-0.1	-0.7
Crohns Disease (2017)	0.7	1.6	4.4	-0.6	-2.1	-0.3
Irritable Bowel Disease (IBD)	0.8	2.0	3.0	-0.4	-1.7	1.6
Ulcerative Colitis (UC)	1.1	2.1	5.2	-0.2	-1.0	2.3
Major Depression (MDD)	0.2	0.2	0.4	0.7	0.3	0.0
Reaction Time	0.1	0.2	0.4	0.7	0.4	-0.2
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.2	1.3	-0.3	-1.8
Breast Cancer	0.6	1.4	2.7	-1.0	-0.7	1.6
Ovarian Cancer	1.2	1.6	3.7	-0.8	-1.9	-0.6
Prostate Cancer	0.5	0.8	1.6	-0.8	-1.3	-0.2
Age at First Birth	0.3	0.5	1.3	-0.2	-1.1	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	-0.2	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	0.1	0.2	0.9
Coronary Artery Disease (CAD)	0.9	1.1	1.9	1.4	-1.0	-0.6
Crohns Disease (2012)	0.4	0.6	1.5	-0.1	-1.2	-0.6
Mean Putamen Volume	0.6	0.7	1.1	-0.5	-0.9	1.1
Fasting Glucose	0.4	0.5	0.9	0.8	0.9	0.2
HbA1C	0.5	0.6	0.8	0.5	0.9	-0.8
HDL Cholesterol	0.6	1.0	1.7	-0.7	-0.9	1.3
LDL Cholesterol	1.0	1.5	2.9	-0.5	-1.7	-1.2
Lupus	0.3	0.4	0.8	-0.5	-0.9	0.5
Neuroticism (2016)	0.1	0.2	0.3	-0.4	0.5	0.4
Primary Biliary Cirrhosis	0.3	0.4	0.6	-0.6	-0.8	-0.5
Rheumatoid Arthritis	0.3	0.4	0.9	-0.9	-0.4	0.6
Schizophrenia (2014)	0.4	0.8	1.5	0.5	-0.8	-1.2
Triglycerides	0.5	0.8	1.5	1.2	0.4	-0.9
Type 2 Diabetes (T2D) (2012)	0.8	1.0	2.4	-1.5	-0.7	-0.3
Ulcerative Colitis	0.9	1.3	2.0	-0.4	-1.3	1.4
Blood Eosinophil Count	1.9	14.9	32.5	5.7	3.5	0.0
Blood Platelet Count	0.1	1.3	2.1	-1.3	-1.5	-0.1
Blood Red Count	0.0	0.1	0.4	0.6	-0.0	-0.1
Blood White Count	0.3	2.5	6.0	2.4	1.0	-0.7
Heel T-Score	0.2	1.8	3.1	-0.9	-1.8	-1.3
BMI	0.2	1.3	2.7	0.8	0.6	-1.6
Height	0.1	2.2	3.3	-1.8	1.8	-0.4
Waist Hip Ratio (WHR)	0.8	3.7	9.3	-1.1	-3.0	-0.8
Systolic Blood Pressure	0.3	1.3	2.2	-0.7	-1.5	-1.1
Smoking Status	1.2	2.8	5.4	2.3	1.7	-0.5
Allergy or Eczema	0.3	0.7	1.7	-0.5	-0.5	1.3
Cardiovascular Disease	0.3	0.9	1.9	-0.2	-0.8	-1.4
Hypothyroidism (self reported)	0.5	1.1	2.0	1.4	1.1	-0.1
Respiratory disease	1.2	2.6	3.4	1.8	1.8	1.2
Type 2 Diabetes (T2D) (2018)	1.2	2.2	5.4	1.1	0.3	-2.3
Lung FEV1/FVC ratio	0.2	1.0	1.7	-1.1	-0.3	1.3
Lung FVC	0.1	0.4	0.9	-0.6	-1.0	-0.1
Neuroticism	0.4	1.1	3.1	-0.1	-0.3	-1.8
Chronotype (morning person)	0.4	0.9	2.4	-1.6	0.6	-0.0
Hair Pigment	0.0	0.9	2.4	-0.4	0.2	-1.6
Tanning	0.1	1.2	2.5	-0.8	-1.6	-0.6
Hand grip strength (left)	0.1	0.2	0.4	-0.2	0.6	-0.5
Number of treatments/medications taken	0.6	1.0	2.9	1.7	0.0	0.4
Average weekly spirits intake	0.3	0.4	0.7	0.9	-0.1	0.6
Sensitivity / hurt feelings	0.7	1.2	1.6	1.3	1.1	-0.9
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.2	0.6	-0.2
Hearing difficulty/problems: Yes	0.7	1.1	1.5	0.7	-1.1	1.2
Relative age of first facial hair	1.7	3.4	4.9	2.1	2.2	1.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	-0.7	-0.1	0.9
Ever used hormone-replacement therapy (HRT)	0.8	1.1	2.3	1.5	0.8	-0.5
Ever had hysterectomy (womb removed)	0.3	0.3	0.7	0.1	0.8	0.5
Systolic blood pressure, automated reading	0.2	0.5	0.7	-0.3	-0.8	-0.8
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	1.6	1.3	1.2	-0.9
Angina	0.2	0.3	0.7	-0.5	-0.2	0.8
Medication for hormone replacement therapy	0.7	0.8	1.2	1.0	-0.1	1.1
Vitamin and mineral supplements	0.3	0.4	0.8	-0.4	0.9	-0.3
Supplements: Zinc	0.0	0.0	0.0	0.2	-0.0	-0.0
Medication: Co-codamol	0.3	0.3	0.8	-0.9	-0.3	0.2
Medication: Metformin	0.6	0.9	2.4	-0.2	-0.5	-1.5
Diabetes (father)	0.1	0.2	0.3	-0.6	0.5	-0.2
Diabetes (mother)	0.9	1.2	3.4	-0.4	-0.1	-1.8
Severe depression (siblings)	1.0	1.1	1.6	0.7	-1.3	-1.1
Pack years adult smoking proportion	0.7	1.1	1.7	0.9	1.3	0.8
Impedance of leg (right)	0.2	1.0	1.3	-1.0	-0.9	1.1
Leg fat-free mass (left)	0.4	1.9	3.0	0.8	1.4	-1.7
Trunk fat percentage	0.2	0.6	0.9	0.9	0.4	-0.9
Hand grip strength (right)	0.2	0.5	1.2	0.1	1.1	-0.5
Townsend deprivation index at recruitment	0.5	0.6	0.8	0.9	-0.6	-0.9
Current tobacco smoking	0.5	0.8	1.9	1.4	0.2	-0.6
Average weekly fortified wine intake	2.2	2.6	3.1	1.8	1.4	1.6
Maternal smoking around birth	0.1	0.2	0.6	-0.1	-0.2	-0.8
Fed-up feelings	0.2	0.4	0.6	-0.0	0.7	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.1	-1.5	-1.0	-0.7
Relative age voice broke	0.1	0.2	0.5	0.1	0.7	-0.3
Taking other prescription medications	0.0	0.0	0.1	0.0	-0.1	0.3
Age when periods started (menarche)	0.1	0.4	0.7	0.0	0.8	-0.7
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	2.9	1.7	1.7	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.3	-0.5	-0.7	-1.5
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.3	-0.9	-1.5	-1.2
Qualifications: CSEs or equivalent	1.6	2.1	5.1	-2.3	0.2	-1.1
Serious illness, injury or assault to yourself	1.0	1.2	3.2	-0.6	0.3	1.8
High blood pressure	0.6	1.7	2.6	-1.2	-1.6	-1.0
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	-0.5	-0.9	0.3
Multivitamins +/- minerals	0.3	0.4	0.6	0.1	-0.8	0.8
Stomach or abdominal pain in last month	0.6	0.8	1.6	-0.1	0.9	1.3
Supplements: Glucosamine	0.1	0.1	0.3	0.1	0.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.4	0.4	-1.2	1.1
Medication: Atenolol	0.2	0.3	0.7	0.4	0.1	-0.8
Medication: Levothyroxine sodium	0.3	0.5	1.0	1.0	0.5	-0.5
Sitting height	0.1	0.7	0.9	-0.9	0.7	-1.0
Chronic bronchitis/emphysema (father)	0.5	0.5	1.3	0.1	-1.1	0.6
High blood pressure (mother)	1.1	1.6	2.6	-0.9	-1.1	-1.6
Body mass index (BMI)	0.5	2.3	4.0	1.5	0.7	-2.0
Impedance of leg (left)	0.2	1.1	1.3	-0.9	-1.2	1.1
Leg predicted mass (left)	0.4	2.0	3.3	0.8	1.4	-1.8
Trunk fat mass	0.2	1.0	1.8	0.9	0.7	-1.3
Waist circumference	0.5	1.9	5.5	0.4	0.2	-2.4
Number of incorrect matches in round	0.7	1.1	2.3	0.6	1.5	0.9
Past tobacco smoking	1.5	2.7	6.0	-2.5	-1.5	0.1
Alcohol usually taken with meals	0.3	0.5	1.3	0.5	0.2	1.1
Nervous feelings	0.2	0.4	0.7	0.6	-0.2	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	3.5	-0.6	0.2	-1.9
Hearing difficulty/problems with background noise	0.8	1.3	2.5	-0.7	-1.0	1.6
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	0.6	0.3	-0.2
Had menopause	0.9	1.1	3.2	-0.2	0.3	1.8
Had other major operations	0.4	0.5	0.8	-0.6	0.6	0.9
Forced vital capacity (FVC)	0.0	0.2	0.4	-0.3	-0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.7	-0.7	-0.9	-1.3
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.5	-0.1	-1.2	-0.8
Qualifications: None of the above	0.9	1.9	2.2	1.4	1.5	1.2
Financial difficulties in last 2 years	0.4	0.5	1.1	-1.0	-0.2	-0.6
Mouth/teeth dental problems	0.3	0.4	0.8	-0.9	0.6	0.1
Heart attack	1.9	2.4	3.8	-1.9	-1.9	0.2
Allergy	0.0	0.1	0.3	-0.1	-0.1	-0.5
Pain all over the body in last month	1.1	1.2	3.2	0.6	0.1	1.8
Diabetes (self-reported)	0.2	0.3	0.7	0.3	-0.3	-0.9
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.6	1.3	1.3	-0.1
Medication: Ramipril	1.2	1.5	2.6	-1.6	-1.4	0.3
Medication: Simvastatin	0.2	0.3	0.7	0.6	-0.2	0.8
Fluid intelligence score	1.1	2.3	3.4	1.8	-0.4	-1.8
Illnesses of siblings	0.4	0.6	1.8	-1.4	0.2	-0.1
Neuroticism score	0.3	0.7	2.0	-0.1	0.2	-1.4
Weight	0.6	2.8	5.6	1.1	1.2	-2.4
Impedance of arm (right)	0.3	1.2	1.5	-1.2	-1.0	1.0
Arm fat percentage (right)	0.4	1.7	3.6	1.1	0.5	-1.9
Trunk fat-free mass	0.4	2.1	4.4	0.6	1.3	-2.1
Hip circumference	0.9	3.8	5.8	1.4	1.9	-2.4
Time employed in main current job	0.5	0.5	1.1	-0.6	-1.1	0.3
Alcohol intake versus 10 years previously	1.8	2.7	3.9	0.9	2.0	-1.9
Father’s age at death	1.6	2.2	2.5	1.6	1.6	-1.3
Worrier / anxious feelings	0.4	0.7	1.8	-0.5	0.1	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.2	-0.9	-0.4	1.1
Falls in the last year	0.7	1.0	1.8	-0.3	-1.0	-1.4
Hair/balding pattern: Pattern 3	0.4	0.6	1.5	0.3	-0.4	-1.2
Number of live births	0.8	1.2	1.6	-1.2	-0.8	1.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	0.8	-0.9	-0.8	0.1
Pulse rate	0.8	1.3	2.1	-0.9	-1.5	-1.0
Happiness	2.2	2.7	7.6	0.6	-0.3	-2.8
Noisy workplace	0.3	0.3	0.9	0.1	0.3	-0.9
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.1	2.0	-0.4	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.0	1.0	0.7	-0.0
Mouth/teeth dental problems: Dentures	1.0	1.7	4.5	2.1	0.2	-0.8
Asthma	0.6	1.1	2.1	1.5	0.9	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	0.8	0.4	-0.5
Medication: Cholesterol lowering	0.6	1.0	1.8	-1.0	-1.4	-0.4
Depression (self-reported)	0.0	0.1	0.1	0.2	0.1	-0.4
Medication: Lansoprazole	1.5	1.7	2.9	-1.7	-1.4	-0.4
Prospective memory result	4.7	5.8	13.2	-3.6	-1.9	0.7
Lung cancer (father)	1.0	1.2	1.8	-1.4	-0.9	-0.9
Illnesses of mother	0.2	0.3	0.7	0.4	0.0	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.9	-0.8	-0.9	-0.6
Pulse wave Arterial Stiffness index	0.1	0.2	0.3	0.5	-0.5	-0.0
Impedance of arm (left)	0.4	1.7	3.0	-1.3	-0.7	1.7
Arm fat mass (right)	0.5	2.2	4.8	1.0	0.9	-2.2
Trunk predicted mass	0.4	2.1	4.2	0.6	1.3	-2.1
Standing height	0.1	0.9	1.3	-1.0	1.1	-0.6
Length of working week for main job	2.2	2.4	4.1	2.0	-0.7	-1.6
Exposure to tobacco smoke at home	1.9	2.1	3.5	-1.5	-0.7	1.9
Breastfed as a baby	0.2	0.3	0.7	0.2	-0.1	-0.9
Tense / ‘highly strung’	0.6	1.0	2.0	0.9	0.4	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.5	1.0	1.0	0.5	-0.6
Hair/balding pattern: Pattern 4	0.4	1.1	2.3	1.5	0.4	-0.9
Birth weight of first child	0.4	0.6	1.2	0.8	-0.3	-1.1
Peak expiratory flow (PEF)	0.2	0.6	1.2	-0.3	-0.7	1.1
Pulse wave reflection index	0.1	0.1	0.3	0.5	0.1	-0.0
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	0.3	0.4	-0.1
Loud music exposure frequency	0.7	0.7	1.5	-0.5	0.7	-1.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.0	-0.1	0.1	-1.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.8	-0.7	-0.9	-0.6
Blood clot in the leg (DVT)	0.0	0.0	0.0	-0.1	-0.2	0.2
Medication: Paracetamol	0.5	0.8	1.3	0.8	0.5	1.2
Headache pain in last month	0.2	0.4	0.7	-0.1	0.8	-0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.4	0.6	1.2	0.4
Glaucoma (self-reported)	0.3	0.4	0.8	-0.4	-0.9	-0.2
Gout (self-reported)	0.3	0.4	0.5	0.6	-0.7	-0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.1	1.1	0.8	-0.4
Medication: Amlodipine	0.3	0.4	1.1	-0.4	-1.0	0.2
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.3	1.1	0.3	0.6
Birth weight	0.2	0.4	0.6	0.4	-0.8	-0.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.9	0.6	0.9	0.7
High blood pressure (siblings)	0.5	0.7	1.8	1.3	0.4	0.4
Forced vital capacity (FVC), Best measure	0.1	0.4	1.0	-0.3	-0.3	-1.0
Body fat percentage	0.2	0.8	1.3	1.0	0.4	-1.1
Leg fat percentage (right)	0.3	1.0	1.9	1.0	0.3	-1.4
Arm fat-free mass (right)	0.3	1.7	3.5	0.6	1.1	-1.9
Exposure to tobacco smoke outside home	0.7	0.9	2.1	-1.4	-0.7	0.4
Comparative body size at age 10	0.0	0.1	0.1	0.3	-0.4	-0.1
Number of full brothers	0.1	0.1	0.1	-0.3	0.1	0.3
Worry too long after embarrassment	0.3	0.5	1.4	0.1	0.0	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.4	-0.0	-0.9
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	0.5	0.0	-0.4
Number of children fathered	1.5	1.7	2.8	0.8	1.2	1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	1.2	0.7	-0.6
Age at first live birth	0.7	1.2	3.6	-0.2	0.3	-1.9
Pulse wave peak to peak time	0.2	0.2	0.4	-0.6	0.5	-0.3
Health satisfaction	0.9	1.2	3.2	0.5	-0.2	-1.8
Shortness of breath walking on level ground	0.9	1.1	2.3	0.0	-1.5	-0.9
Qualifications: College or University degree	0.1	0.4	0.9	0.9	0.1	0.6
Eye problems/disorders: None of the above	1.3	1.5	3.0	1.7	1.1	-0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	-0.6	0.3	0.7
Emphysema/chronic bronchitis	1.4	1.6	2.0	1.1	1.3	1.4
Medication for pain relief, constipation, heartburn	0.9	1.5	2.5	-1.4	-0.3	-1.6
Neck or shoulder pain in last month	2.6	3.7	5.5	-1.4	-2.3	-1.9
Medication: Blood pressure	0.2	0.3	0.7	-0.5	-0.8	-0.2
Angina (self-reported)	0.3	0.3	0.6	-0.7	-0.1	0.8
Migraine (self-reported)	1.2	1.5	2.8	-0.8	-1.0	-1.7
Medication: Ibuprofen	0.8	1.0	2.0	1.4	0.9	0.1
Medication: Allopurinol	0.4	0.5	0.9	0.8	-0.9	-0.2
Medication: Omeprazole	0.8	1.0	2.6	-0.6	-1.6	0.2
Medication: Seretide 50 evohaler	0.5	0.6	1.2	-0.1	1.1	0.8
Mean time to correctly identify matches	0.2	0.3	0.8	0.9	0.3	-0.3
Heart disease (mother)	0.0	0.1	0.1	0.3	0.2	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	2.0	2.6	1.4	1.2	-1.6
Whole body fat mass	0.3	1.3	2.5	1.0	0.7	-1.6
Leg fat mass (right)	0.4	1.4	3.6	0.8	0.4	-1.9
Arm predicted mass (right)	0.3	1.5	2.3	0.6	1.3	-1.5
Pulse rate, automated reading	0.1	0.2	0.3	0.4	-0.4	-0.5
Alcohol intake frequency.	1.3	3.1	6.8	-1.4	-0.6	-2.6
Comparative height size at age 10	0.2	1.1	2.1	-0.5	1.1	-1.4
Number of full sisters	0.2	0.3	0.6	0.0	-0.7	-0.5
Suffer from ‘nerves’	0.1	0.2	0.5	0.7	0.1	0.3
Overall health rating	0.7	1.6	2.2	-1.1	-1.5	-1.1
Chest pain or discomfort	0.5	0.7	1.4	-0.8	-1.2	-0.2
Had major operations	0.2	0.2	0.6	0.1	-0.3	-0.8
Age at last live birth	0.5	0.7	1.9	1.4	0.3	0.2
Family relationship satisfaction	1.4	1.7	2.4	1.1	1.2	-1.6
Leg pain on walking	0.1	0.1	0.1	-0.2	-0.3	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.0	-0.2	-0.4	-1.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	0.2	-0.0	0.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.6	0.7	-0.4	0.4
Medication: Aspirin	0.3	0.3	0.6	0.8	0.4	0.6
Supplements: Vitamin C	0.1	0.1	0.2	0.5	0.1	0.4
Knee pain experienced in last month	1.4	2.1	5.0	-0.9	-0.8	-2.2
Hypertension (Self-reported)	0.3	0.9	1.3	-0.9	-1.1	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.8	-0.5	-0.2	0.9
Illnesses of father: Heart disease	0.5	0.7	1.8	-0.7	-1.3	-0.2
Illnesses of siblings: Diabetes	0.4	0.5	1.0	0.7	-1.0	0.4
Smoking status: Previous	0.9	1.3	2.6	1.6	1.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.9	-0.0	0.6	-1.0
Whole body fat-free mass	0.4	2.3	4.0	0.8	1.5	-2.0
Leg fat-free mass (right)	0.3	1.8	3.1	0.8	1.4	-1.8
Arm fat percentage (left)	0.3	1.0	2.2	0.8	0.5	-1.5
Average weekly red wine intake	0.1	0.1	0.2	0.5	-0.1	0.0
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.0	0.1	0.6	-1.0
Mood swings	0.3	0.6	1.3	0.7	1.1	-0.3
Loneliness, isolation	0.2	0.2	0.3	0.4	0.5	-0.6
Long-standing illness, disability or infirmity	0.4	0.7	1.8	-0.3	-1.3	-0.3
Ever had bowel cancer screening	0.3	0.3	0.7	-0.5	0.2	0.8
Diabetes diagnosed by doctor	0.2	0.4	1.0	0.3	0.0	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.3	0.4	-0.2	0.5
Friendships satisfaction	2.3	2.9	5.8	2.4	1.7	-0.1
Qualifications: nursing, teaching	0.8	1.2	3.3	0.6	-0.3	-1.8
Commuting to job workplace: Walk	0.9	1.0	2.1	0.4	1.4	0.8
Eye problems/disorders: Cataract	2.4	2.8	6.9	-2.6	-1.2	0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.7	0.9	0.6	0.7
Medication for cholesterol	0.5	0.7	1.8	-0.6	1.3	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	1.3	0.3	1.1	1.0
Back pain experienced in last month	0.1	0.1	0.1	-0.4	0.2	-0.3
Mineral and other dietary supplements	0.1	0.1	0.2	-0.5	0.4	-0.1
Breast cancer (self-reported)	0.7	0.8	1.9	-1.4	-0.7	-0.2
Asthma (self-reported)	0.6	1.1	2.1	1.5	0.9	0.6
Osteoporosis (self-reported)	0.7	0.9	1.7	-1.3	-0.9	0.5
Osteoarthritis (self-reported)	3.9	5.1	6.4	-1.7	-2.5	-2.5
Medication: Aspirin	0.1	0.2	0.3	0.5	0.2	0.4
Medication: Gliclazide	0.8	0.9	1.9	-0.5	-0.8	-1.4
Illnesses of father: None of the above (group 1)	0.8	1.0	1.8	0.9	1.4	-0.5
Smoking status: Current	0.5	0.8	2.0	1.4	0.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	1.7	-0.5	-1.3	1.3
Whole body water mass	0.4	2.5	4.3	0.9	1.5	-2.1
Leg predicted mass (right)	0.3	1.9	3.0	0.8	1.4	-1.7
Arm fat mass (left)	0.4	1.8	4.1	0.8	0.8	-2.0
Number of self-reported non-cancer illnesses	0.3	0.6	1.4	-0.4	-1.2	0.5
Average weekly champagne plus white wine intake	1.0	1.3	3.7	1.9	0.5	-0.2
Miserableness	0.4	0.7	1.5	0.7	0.3	-1.2
Guilty feelings	0.2	0.3	0.7	0.6	0.8	-0.2
Wears glasses or contact lenses	0.7	0.8	1.7	-0.2	-0.7	-1.3
Ever taken oral contraceptive pill	0.6	0.7	1.5	0.7	1.2	-0.4
Hearing aid user	1.9	2.2	4.9	2.2	1.3	0.2
Mother’s age at death	0.1	0.1	0.2	0.4	-0.4	-0.3
Financial situation satisfaction	1.9	2.4	6.1	-1.0	-0.4	-2.5
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.7	0.5	0.8	0.7
Commuting to job workplace: Public transport	0.2	0.2	0.3	-0.6	-0.5	0.3
Eye problems/disorders: Glaucoma	1.8	2.1	2.9	-1.7	-1.7	-0.8
Medication: Blood pressure	1.7	3.2	6.2	-0.7	-2.5	-1.7
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	-0.0	-0.5	1.0
Supplements: Fish oil (including cod liver oil)	0.7	1.0	1.7	0.4	-1.0	-1.3
High cholesterol (Self-reported)	0.2	0.4	0.9	0.1	-0.5	1.0
Medication: Bendroflumethiazide	1.1	1.6	2.8	-0.2	-1.5	-1.7
Medication: Paracetamol	0.3	0.5	1.3	0.4	0.1	1.1
Medication: Lisinopril	0.3	0.4	0.9	-0.3	-0.5	-1.0
Medication: Atorvastatin	0.6	0.7	1.0	-1.0	-0.6	-0.9
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.1	-0.3	-0.3
Alcohol drinker status: Never	2.2	2.7	6.0	-1.4	-0.3	-2.4
Ever smoked	2.2	3.8	8.5	2.9	1.7	-0.1
Basal metabolic rate	0.5	2.7	5.2	0.9	1.4	-2.3
Leg fat percentage (left)	0.3	1.1	2.0	1.1	0.1	-1.4
Arm fat-free mass (left)	0.6	3.1	6.0	1.0	1.5	-2.5
Number of operations (self-reported)	0.3	0.5	0.8	0.7	0.3	-0.9
Average weekly beer plus cider intake	0.0	0.0	0.1	-0.2	0.2	0.3
Irritability	0.4	0.7	0.7	0.8	0.8	-0.8
Risk taking	2.1	3.1	6.4	2.5	1.5	0.9
Ever had prostate specific antigen (PSA) test	0.7	0.9	2.3	0.5	-1.5	-0.0
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.1	0.5	0.3
Age started oral contraceptive pill	0.7	0.8	2.0	0.6	1.4	-0.2
Diastolic blood pressure, automated reading	0.2	0.7	1.5	0.6	-0.5	-1.2
Ever depressed for a whole week	1.5	1.9	3.9	-0.8	-2.0	-1.1
Unable to work because of sickness or disability	0.6	0.8	1.0	0.8	1.0	0.9
Commuting to job workplace: Cycle	1.3	1.6	2.3	-1.0	-1.5	-1.2
Myopia	0.5	0.7	1.3	-1.1	-0.9	0.3
Vascular/heart problems diagnosed by doctor	0.6	1.5	2.6	1.3	1.6	0.4
Cholesterol lowering medication	0.9	1.3	2.7	0.9	0.7	1.6
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	4.1	-1.2	-2.0	0.2
Pain experienced in last month	0.2	0.4	1.2	-0.1	-0.1	1.1
Supplements: Calcium	2.9	3.2	6.8	-1.6	-2.6	-0.6
Basal cell carcinoma (self-reported)	1.0	1.2	1.9	1.4	-0.7	-1.0
Heart attack/myocardial infarction (self-reported)	2.2	2.8	4.3	-2.1	-2.0	0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.1	-0.0	0.4
Heart disease (siblings)	0.2	0.2	0.3	-0.6	-0.5	0.2
Alcohol drinker status: Previous	0.2	0.3	0.4	-0.6	0.5	-0.3
Pack years of smoking	1.0	1.5	1.7	1.1	1.2	1.3
Impedance of whole body	0.3	1.6	2.6	-1.2	-0.8	1.6
Leg fat mass (left)	0.4	1.4	3.5	0.9	0.2	-1.9
Arm predicted mass (left)	0.6	3.2	5.2	1.3	1.7	-2.3