Hub : Genes

OR7E91P

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Lung Squamous Cell Carcinoma 0.0493 0.0242 1.1e-04 0.021 0.043 0.047 NA 0.043 1.8e-03 9.7e-06 4.5e-06 NA 1.1e-05
2 TCGA Stomach Adenocarcinoma 0.1240 0.0630 2.8e-03 0.005 0.021 0.000 NA 0.017 1.4e-01 1.1e-02 3.1e-01 NA 2.0e-02
3 TCGA Thyroid Carcinoma 0.1750 0.0610 2.9e-06 0.076 0.072 0.068 NA 0.074 7.4e-08 1.7e-07 3.6e-07 NA 1.1e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.1 0.2 0.4 -0.4 0.0
Bipolar Disorder or Schizophrenia 0.5 1.2 1.9 1.3 -0.4 -1.4
Depressed Affect (Nagel 2018) 0.1 0.3 0.5 0.6 0.7 0.0
Depression (Nagel 2018) 0.2 0.4 0.6 -0.7 -0.3 -0.7
Intelligence (Savage-Jansen 2018) 0.6 1.9 3.3 1.5 -0.4 -1.8
Neuroticism (Nagel 2018) 0.5 1.2 2.2 1.5 1.0 -0.7
Schizophrenia (2018) 0.1 0.2 0.5 0.7 0.4 0.1
Schizophrenia vs Biploar Disorder 1.3 1.7 4.0 -2.0 -1.0 0.0
Worry (Nagel 2018) 0.3 0.6 1.6 0.5 -0.1 -1.2
Alzheimer’s Disease (in mother) 0.3 0.4 0.9 0.2 -0.4 -1.0
Alzheimer’s Disease (in father) 0.4 0.4 1.2 -1.1 0.1 0.3
Alzheimer’s Disease (including proxy) 0.3 0.4 0.7 -0.8 -0.1 -0.7
Crohns Disease (2017) 0.7 1.6 4.4 -0.6 -2.1 -0.3
Irritable Bowel Disease (IBD) 0.8 2.0 3.0 -0.4 -1.7 1.6
Ulcerative Colitis (UC) 1.1 2.1 5.2 -0.2 -1.0 2.3
Major Depression (MDD) 0.2 0.2 0.4 0.7 0.3 0.0
Reaction Time 0.1 0.2 0.4 0.7 0.4 -0.2
Verbal and Numeric Reasoning (VNR) 0.7 1.7 3.2 1.3 -0.3 -1.8
Breast Cancer 0.6 1.4 2.7 -1.0 -0.7 1.6
Ovarian Cancer 1.2 1.6 3.7 -0.8 -1.9 -0.6
Prostate Cancer 0.5 0.8 1.6 -0.8 -1.3 -0.2
Age at First Birth 0.3 0.5 1.3 -0.2 -1.1 -0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 -0.2 0.0
Body Mass Index (BMI) (2010) 0.2 0.3 0.8 0.1 0.2 0.9
Coronary Artery Disease (CAD) 0.9 1.1 1.9 1.4 -1.0 -0.6
Crohns Disease (2012) 0.4 0.6 1.5 -0.1 -1.2 -0.6
Mean Putamen Volume 0.6 0.7 1.1 -0.5 -0.9 1.1
Fasting Glucose 0.4 0.5 0.9 0.8 0.9 0.2
HbA1C 0.5 0.6 0.8 0.5 0.9 -0.8
HDL Cholesterol 0.6 1.0 1.7 -0.7 -0.9 1.3
LDL Cholesterol 1.0 1.5 2.9 -0.5 -1.7 -1.2
Lupus 0.3 0.4 0.8 -0.5 -0.9 0.5
Neuroticism (2016) 0.1 0.2 0.3 -0.4 0.5 0.4
Primary Biliary Cirrhosis 0.3 0.4 0.6 -0.6 -0.8 -0.5
Rheumatoid Arthritis 0.3 0.4 0.9 -0.9 -0.4 0.6
Schizophrenia (2014) 0.4 0.8 1.5 0.5 -0.8 -1.2
Triglycerides 0.5 0.8 1.5 1.2 0.4 -0.9
Type 2 Diabetes (T2D) (2012) 0.8 1.0 2.4 -1.5 -0.7 -0.3
Ulcerative Colitis 0.9 1.3 2.0 -0.4 -1.3 1.4
Blood Eosinophil Count 1.9 14.9 32.5 5.7 3.5 0.0
Blood Platelet Count 0.1 1.3 2.1 -1.3 -1.5 -0.1
Blood Red Count 0.0 0.1 0.4 0.6 -0.0 -0.1
Blood White Count 0.3 2.5 6.0 2.4 1.0 -0.7
Heel T-Score 0.2 1.8 3.1 -0.9 -1.8 -1.3
BMI 0.2 1.3 2.7 0.8 0.6 -1.6
Height 0.1 2.2 3.3 -1.8 1.8 -0.4
Waist Hip Ratio (WHR) 0.8 3.7 9.3 -1.1 -3.0 -0.8
Systolic Blood Pressure 0.3 1.3 2.2 -0.7 -1.5 -1.1
Smoking Status 1.2 2.8 5.4 2.3 1.7 -0.5
Allergy or Eczema 0.3 0.7 1.7 -0.5 -0.5 1.3
Cardiovascular Disease 0.3 0.9 1.9 -0.2 -0.8 -1.4
Hypothyroidism (self reported) 0.5 1.1 2.0 1.4 1.1 -0.1
Respiratory disease 1.2 2.6 3.4 1.8 1.8 1.2
Type 2 Diabetes (T2D) (2018) 1.2 2.2 5.4 1.1 0.3 -2.3
Lung FEV1/FVC ratio 0.2 1.0 1.7 -1.1 -0.3 1.3
Lung FVC 0.1 0.4 0.9 -0.6 -1.0 -0.1
Neuroticism 0.4 1.1 3.1 -0.1 -0.3 -1.8
Chronotype (morning person) 0.4 0.9 2.4 -1.6 0.6 -0.0
Hair Pigment 0.0 0.9 2.4 -0.4 0.2 -1.6
Tanning 0.1 1.2 2.5 -0.8 -1.6 -0.6
Hand grip strength (left) 0.1 0.2 0.4 -0.2 0.6 -0.5
Number of treatments/medications taken 0.6 1.0 2.9 1.7 0.0 0.4
Average weekly spirits intake 0.3 0.4 0.7 0.9 -0.1 0.6
Sensitivity / hurt feelings 0.7 1.2 1.6 1.3 1.1 -0.9
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.3 -0.2 0.6 -0.2
Hearing difficulty/problems: Yes 0.7 1.1 1.5 0.7 -1.1 1.2
Relative age of first facial hair 1.7 3.4 4.9 2.1 2.2 1.1
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.9 -0.7 -0.1 0.9
Ever used hormone-replacement therapy (HRT) 0.8 1.1 2.3 1.5 0.8 -0.5
Ever had hysterectomy (womb removed) 0.3 0.3 0.7 0.1 0.8 0.5
Systolic blood pressure, automated reading 0.2 0.5 0.7 -0.3 -0.8 -0.8
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 1.6 1.3 1.2 -0.9
Angina 0.2 0.3 0.7 -0.5 -0.2 0.8
Medication for hormone replacement therapy 0.7 0.8 1.2 1.0 -0.1 1.1
Vitamin and mineral supplements 0.3 0.4 0.8 -0.4 0.9 -0.3
Supplements: Zinc 0.0 0.0 0.0 0.2 -0.0 -0.0
Medication: Co-codamol 0.3 0.3 0.8 -0.9 -0.3 0.2
Medication: Metformin 0.6 0.9 2.4 -0.2 -0.5 -1.5
Diabetes (father) 0.1 0.2 0.3 -0.6 0.5 -0.2
Diabetes (mother) 0.9 1.2 3.4 -0.4 -0.1 -1.8
Severe depression (siblings) 1.0 1.1 1.6 0.7 -1.3 -1.1
Pack years adult smoking proportion 0.7 1.1 1.7 0.9 1.3 0.8
Impedance of leg (right) 0.2 1.0 1.3 -1.0 -0.9 1.1
Leg fat-free mass (left) 0.4 1.9 3.0 0.8 1.4 -1.7
Trunk fat percentage 0.2 0.6 0.9 0.9 0.4 -0.9
Hand grip strength (right) 0.2 0.5 1.2 0.1 1.1 -0.5
Townsend deprivation index at recruitment 0.5 0.6 0.8 0.9 -0.6 -0.9
Current tobacco smoking 0.5 0.8 1.9 1.4 0.2 -0.6
Average weekly fortified wine intake 2.2 2.6 3.1 1.8 1.4 1.6
Maternal smoking around birth 0.1 0.2 0.6 -0.1 -0.2 -0.8
Fed-up feelings 0.2 0.4 0.6 -0.0 0.7 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 2.1 -1.5 -1.0 -0.7
Relative age voice broke 0.1 0.2 0.5 0.1 0.7 -0.3
Taking other prescription medications 0.0 0.0 0.1 0.0 -0.1 0.3
Age when periods started (menarche) 0.1 0.4 0.7 0.0 0.8 -0.7
Bilateral oophorectomy (both ovaries removed) 1.7 1.9 2.9 1.7 1.7 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 2.3 -0.5 -0.7 -1.5
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 2.3 -0.9 -1.5 -1.2
Qualifications: CSEs or equivalent 1.6 2.1 5.1 -2.3 0.2 -1.1
Serious illness, injury or assault to yourself 1.0 1.2 3.2 -0.6 0.3 1.8
High blood pressure 0.6 1.7 2.6 -1.2 -1.6 -1.0
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.8 -0.5 -0.9 0.3
Multivitamins +/- minerals 0.3 0.4 0.6 0.1 -0.8 0.8
Stomach or abdominal pain in last month 0.6 0.8 1.6 -0.1 0.9 1.3
Supplements: Glucosamine 0.1 0.1 0.3 0.1 0.1 -0.6
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 1.4 0.4 -1.2 1.1
Medication: Atenolol 0.2 0.3 0.7 0.4 0.1 -0.8
Medication: Levothyroxine sodium 0.3 0.5 1.0 1.0 0.5 -0.5
Sitting height 0.1 0.7 0.9 -0.9 0.7 -1.0
Chronic bronchitis/emphysema (father) 0.5 0.5 1.3 0.1 -1.1 0.6
High blood pressure (mother) 1.1 1.6 2.6 -0.9 -1.1 -1.6
Body mass index (BMI) 0.5 2.3 4.0 1.5 0.7 -2.0
Impedance of leg (left) 0.2 1.1 1.3 -0.9 -1.2 1.1
Leg predicted mass (left) 0.4 2.0 3.3 0.8 1.4 -1.8
Trunk fat mass 0.2 1.0 1.8 0.9 0.7 -1.3
Waist circumference 0.5 1.9 5.5 0.4 0.2 -2.4
Number of incorrect matches in round 0.7 1.1 2.3 0.6 1.5 0.9
Past tobacco smoking 1.5 2.7 6.0 -2.5 -1.5 0.1
Alcohol usually taken with meals 0.3 0.5 1.3 0.5 0.2 1.1
Nervous feelings 0.2 0.4 0.7 0.6 -0.2 -0.8
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.3 3.5 -0.6 0.2 -1.9
Hearing difficulty/problems with background noise 0.8 1.3 2.5 -0.7 -1.0 1.6
Hair/balding pattern: Pattern 2 0.1 0.2 0.4 0.6 0.3 -0.2
Had menopause 0.9 1.1 3.2 -0.2 0.3 1.8
Had other major operations 0.4 0.5 0.8 -0.6 0.6 0.9
Forced vital capacity (FVC) 0.0 0.2 0.4 -0.3 -0.2 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 1.7 -0.7 -0.9 -1.3
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.5 -0.1 -1.2 -0.8
Qualifications: None of the above 0.9 1.9 2.2 1.4 1.5 1.2
Financial difficulties in last 2 years 0.4 0.5 1.1 -1.0 -0.2 -0.6
Mouth/teeth dental problems 0.3 0.4 0.8 -0.9 0.6 0.1
Heart attack 1.9 2.4 3.8 -1.9 -1.9 0.2
Allergy 0.0 0.1 0.3 -0.1 -0.1 -0.5
Pain all over the body in last month 1.1 1.2 3.2 0.6 0.1 1.8
Diabetes (self-reported) 0.2 0.3 0.7 0.3 -0.3 -0.9
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 1.6 1.3 1.3 -0.1
Medication: Ramipril 1.2 1.5 2.6 -1.6 -1.4 0.3
Medication: Simvastatin 0.2 0.3 0.7 0.6 -0.2 0.8
Fluid intelligence score 1.1 2.3 3.4 1.8 -0.4 -1.8
Illnesses of siblings 0.4 0.6 1.8 -1.4 0.2 -0.1
Neuroticism score 0.3 0.7 2.0 -0.1 0.2 -1.4
Weight 0.6 2.8 5.6 1.1 1.2 -2.4
Impedance of arm (right) 0.3 1.2 1.5 -1.2 -1.0 1.0
Arm fat percentage (right) 0.4 1.7 3.6 1.1 0.5 -1.9
Trunk fat-free mass 0.4 2.1 4.4 0.6 1.3 -2.1
Hip circumference 0.9 3.8 5.8 1.4 1.9 -2.4
Time employed in main current job 0.5 0.5 1.1 -0.6 -1.1 0.3
Alcohol intake versus 10 years previously 1.8 2.7 3.9 0.9 2.0 -1.9
Father’s age at death 1.6 2.2 2.5 1.6 1.6 -1.3
Worrier / anxious feelings 0.4 0.7 1.8 -0.5 0.1 -1.3
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.2 -0.9 -0.4 1.1
Falls in the last year 0.7 1.0 1.8 -0.3 -1.0 -1.4
Hair/balding pattern: Pattern 3 0.4 0.6 1.5 0.3 -0.4 -1.2
Number of live births 0.8 1.2 1.6 -1.2 -0.8 1.2
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 0.8 -0.9 -0.8 0.1
Pulse rate 0.8 1.3 2.1 -0.9 -1.5 -1.0
Happiness 2.2 2.7 7.6 0.6 -0.3 -2.8
Noisy workplace 0.3 0.3 0.9 0.1 0.3 -0.9
Qualifications: A levels/AS levels or equivalent 0.9 2.0 4.1 2.0 -0.4 -1.4
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.0 1.0 0.7 -0.0
Mouth/teeth dental problems: Dentures 1.0 1.7 4.5 2.1 0.2 -0.8
Asthma 0.6 1.1 2.1 1.5 0.9 0.7
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.7 0.8 0.4 -0.5
Medication: Cholesterol lowering 0.6 1.0 1.8 -1.0 -1.4 -0.4
Depression (self-reported) 0.0 0.1 0.1 0.2 0.1 -0.4
Medication: Lansoprazole 1.5 1.7 2.9 -1.7 -1.4 -0.4
Prospective memory result 4.7 5.8 13.2 -3.6 -1.9 0.7
Lung cancer (father) 1.0 1.2 1.8 -1.4 -0.9 -0.9
Illnesses of mother 0.2 0.3 0.7 0.4 0.0 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 0.9 -0.8 -0.9 -0.6
Pulse wave Arterial Stiffness index 0.1 0.2 0.3 0.5 -0.5 -0.0
Impedance of arm (left) 0.4 1.7 3.0 -1.3 -0.7 1.7
Arm fat mass (right) 0.5 2.2 4.8 1.0 0.9 -2.2
Trunk predicted mass 0.4 2.1 4.2 0.6 1.3 -2.1
Standing height 0.1 0.9 1.3 -1.0 1.1 -0.6
Length of working week for main job 2.2 2.4 4.1 2.0 -0.7 -1.6
Exposure to tobacco smoke at home 1.9 2.1 3.5 -1.5 -0.7 1.9
Breastfed as a baby 0.2 0.3 0.7 0.2 -0.1 -0.9
Tense / ‘highly strung’ 0.6 1.0 2.0 0.9 0.4 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.5 1.0 1.0 0.5 -0.6
Hair/balding pattern: Pattern 4 0.4 1.1 2.3 1.5 0.4 -0.9
Birth weight of first child 0.4 0.6 1.2 0.8 -0.3 -1.1
Peak expiratory flow (PEF) 0.2 0.6 1.2 -0.3 -0.7 1.1
Pulse wave reflection index 0.1 0.1 0.3 0.5 0.1 -0.0
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.1 0.3 0.4 -0.1
Loud music exposure frequency 0.7 0.7 1.5 -0.5 0.7 -1.2
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 1.0 -0.1 0.1 -1.0
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.8 -0.7 -0.9 -0.6
Blood clot in the leg (DVT) 0.0 0.0 0.0 -0.1 -0.2 0.2
Medication: Paracetamol 0.5 0.8 1.3 0.8 0.5 1.2
Headache pain in last month 0.2 0.4 0.7 -0.1 0.8 -0.8
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.4 0.6 1.2 0.4
Glaucoma (self-reported) 0.3 0.4 0.8 -0.4 -0.9 -0.2
Gout (self-reported) 0.3 0.4 0.5 0.6 -0.7 -0.5
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.1 1.1 0.8 -0.4
Medication: Amlodipine 0.3 0.4 1.1 -0.4 -1.0 0.2
Medication: Ventolin 100micrograms inhaler 0.4 0.6 1.3 1.1 0.3 0.6
Birth weight 0.2 0.4 0.6 0.4 -0.8 -0.7
Chronic bronchitis/emphysema (mother) 0.5 0.6 0.9 0.6 0.9 0.7
High blood pressure (siblings) 0.5 0.7 1.8 1.3 0.4 0.4
Forced vital capacity (FVC), Best measure 0.1 0.4 1.0 -0.3 -0.3 -1.0
Body fat percentage 0.2 0.8 1.3 1.0 0.4 -1.1
Leg fat percentage (right) 0.3 1.0 1.9 1.0 0.3 -1.4
Arm fat-free mass (right) 0.3 1.7 3.5 0.6 1.1 -1.9
Exposure to tobacco smoke outside home 0.7 0.9 2.1 -1.4 -0.7 0.4
Comparative body size at age 10 0.0 0.1 0.1 0.3 -0.4 -0.1
Number of full brothers 0.1 0.1 0.1 -0.3 0.1 0.3
Worry too long after embarrassment 0.3 0.5 1.4 0.1 0.0 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.8 0.4 -0.0 -0.9
Wheeze or whistling in the chest in last year 0.1 0.2 0.3 0.5 0.0 -0.4
Number of children fathered 1.5 1.7 2.8 0.8 1.2 1.7
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.4 1.2 0.7 -0.6
Age at first live birth 0.7 1.2 3.6 -0.2 0.3 -1.9
Pulse wave peak to peak time 0.2 0.2 0.4 -0.6 0.5 -0.3
Health satisfaction 0.9 1.2 3.2 0.5 -0.2 -1.8
Shortness of breath walking on level ground 0.9 1.1 2.3 0.0 -1.5 -0.9
Qualifications: College or University degree 0.1 0.4 0.9 0.9 0.1 0.6
Eye problems/disorders: None of the above 1.3 1.5 3.0 1.7 1.1 -0.4
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.5 -0.6 0.3 0.7
Emphysema/chronic bronchitis 1.4 1.6 2.0 1.1 1.3 1.4
Medication for pain relief, constipation, heartburn 0.9 1.5 2.5 -1.4 -0.3 -1.6
Neck or shoulder pain in last month 2.6 3.7 5.5 -1.4 -2.3 -1.9
Medication: Blood pressure 0.2 0.3 0.7 -0.5 -0.8 -0.2
Angina (self-reported) 0.3 0.3 0.6 -0.7 -0.1 0.8
Migraine (self-reported) 1.2 1.5 2.8 -0.8 -1.0 -1.7
Medication: Ibuprofen 0.8 1.0 2.0 1.4 0.9 0.1
Medication: Allopurinol 0.4 0.5 0.9 0.8 -0.9 -0.2
Medication: Omeprazole 0.8 1.0 2.6 -0.6 -1.6 0.2
Medication: Seretide 50 evohaler 0.5 0.6 1.2 -0.1 1.1 0.8
Mean time to correctly identify matches 0.2 0.3 0.8 0.9 0.3 -0.3
Heart disease (mother) 0.0 0.1 0.1 0.3 0.2 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 2.0 2.6 1.4 1.2 -1.6
Whole body fat mass 0.3 1.3 2.5 1.0 0.7 -1.6
Leg fat mass (right) 0.4 1.4 3.6 0.8 0.4 -1.9
Arm predicted mass (right) 0.3 1.5 2.3 0.6 1.3 -1.5
Pulse rate, automated reading 0.1 0.2 0.3 0.4 -0.4 -0.5
Alcohol intake frequency. 1.3 3.1 6.8 -1.4 -0.6 -2.6
Comparative height size at age 10 0.2 1.1 2.1 -0.5 1.1 -1.4
Number of full sisters 0.2 0.3 0.6 0.0 -0.7 -0.5
Suffer from ‘nerves’ 0.1 0.2 0.5 0.7 0.1 0.3
Overall health rating 0.7 1.6 2.2 -1.1 -1.5 -1.1
Chest pain or discomfort 0.5 0.7 1.4 -0.8 -1.2 -0.2
Had major operations 0.2 0.2 0.6 0.1 -0.3 -0.8
Age at last live birth 0.5 0.7 1.9 1.4 0.3 0.2
Family relationship satisfaction 1.4 1.7 2.4 1.1 1.2 -1.6
Leg pain on walking 0.1 0.1 0.1 -0.2 -0.3 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.0 -0.2 -0.4 -1.4
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.6 0.2 -0.0 0.8
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.6 0.7 -0.4 0.4
Medication: Aspirin 0.3 0.3 0.6 0.8 0.4 0.6
Supplements: Vitamin C 0.1 0.1 0.2 0.5 0.1 0.4
Knee pain experienced in last month 1.4 2.1 5.0 -0.9 -0.8 -2.2
Hypertension (Self-reported) 0.3 0.9 1.3 -0.9 -1.1 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.8 -0.5 -0.2 0.9
Illnesses of father: Heart disease 0.5 0.7 1.8 -0.7 -1.3 -0.2
Illnesses of siblings: Diabetes 0.4 0.5 1.0 0.7 -1.0 0.4
Smoking status: Previous 0.9 1.3 2.6 1.6 1.1 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.9 -0.0 0.6 -1.0
Whole body fat-free mass 0.4 2.3 4.0 0.8 1.5 -2.0
Leg fat-free mass (right) 0.3 1.8 3.1 0.8 1.4 -1.8
Arm fat percentage (left) 0.3 1.0 2.2 0.8 0.5 -1.5
Average weekly red wine intake 0.1 0.1 0.2 0.5 -0.1 0.0
Handedness (chirality/laterality): Left-handed 0.4 0.4 1.0 0.1 0.6 -1.0
Mood swings 0.3 0.6 1.3 0.7 1.1 -0.3
Loneliness, isolation 0.2 0.2 0.3 0.4 0.5 -0.6
Long-standing illness, disability or infirmity 0.4 0.7 1.8 -0.3 -1.3 -0.3
Ever had bowel cancer screening 0.3 0.3 0.7 -0.5 0.2 0.8
Diabetes diagnosed by doctor 0.2 0.4 1.0 0.3 0.0 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.2 0.3 0.4 -0.2 0.5
Friendships satisfaction 2.3 2.9 5.8 2.4 1.7 -0.1
Qualifications: nursing, teaching 0.8 1.2 3.3 0.6 -0.3 -1.8
Commuting to job workplace: Walk 0.9 1.0 2.1 0.4 1.4 0.8
Eye problems/disorders: Cataract 2.4 2.8 6.9 -2.6 -1.2 0.0
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.7 0.9 0.6 0.7
Medication for cholesterol 0.5 0.7 1.8 -0.6 1.3 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.8 1.3 0.3 1.1 1.0
Back pain experienced in last month 0.1 0.1 0.1 -0.4 0.2 -0.3
Mineral and other dietary supplements 0.1 0.1 0.2 -0.5 0.4 -0.1
Breast cancer (self-reported) 0.7 0.8 1.9 -1.4 -0.7 -0.2
Asthma (self-reported) 0.6 1.1 2.1 1.5 0.9 0.6
Osteoporosis (self-reported) 0.7 0.9 1.7 -1.3 -0.9 0.5
Osteoarthritis (self-reported) 3.9 5.1 6.4 -1.7 -2.5 -2.5
Medication: Aspirin 0.1 0.2 0.3 0.5 0.2 0.4
Medication: Gliclazide 0.8 0.9 1.9 -0.5 -0.8 -1.4
Illnesses of father: None of the above (group 1) 0.8 1.0 1.8 0.9 1.4 -0.5
Smoking status: Current 0.5 0.8 2.0 1.4 0.4 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 1.7 -0.5 -1.3 1.3
Whole body water mass 0.4 2.5 4.3 0.9 1.5 -2.1
Leg predicted mass (right) 0.3 1.9 3.0 0.8 1.4 -1.7
Arm fat mass (left) 0.4 1.8 4.1 0.8 0.8 -2.0
Number of self-reported non-cancer illnesses 0.3 0.6 1.4 -0.4 -1.2 0.5
Average weekly champagne plus white wine intake 1.0 1.3 3.7 1.9 0.5 -0.2
Miserableness 0.4 0.7 1.5 0.7 0.3 -1.2
Guilty feelings 0.2 0.3 0.7 0.6 0.8 -0.2
Wears glasses or contact lenses 0.7 0.8 1.7 -0.2 -0.7 -1.3
Ever taken oral contraceptive pill 0.6 0.7 1.5 0.7 1.2 -0.4
Hearing aid user 1.9 2.2 4.9 2.2 1.3 0.2
Mother’s age at death 0.1 0.1 0.2 0.4 -0.4 -0.3
Financial situation satisfaction 1.9 2.4 6.1 -1.0 -0.4 -2.5
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.7 0.5 0.8 0.7
Commuting to job workplace: Public transport 0.2 0.2 0.3 -0.6 -0.5 0.3
Eye problems/disorders: Glaucoma 1.8 2.1 2.9 -1.7 -1.7 -0.8
Medication: Blood pressure 1.7 3.2 6.2 -0.7 -2.5 -1.7
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.1 -0.0 -0.5 1.0
Supplements: Fish oil (including cod liver oil) 0.7 1.0 1.7 0.4 -1.0 -1.3
High cholesterol (Self-reported) 0.2 0.4 0.9 0.1 -0.5 1.0
Medication: Bendroflumethiazide 1.1 1.6 2.8 -0.2 -1.5 -1.7
Medication: Paracetamol 0.3 0.5 1.3 0.4 0.1 1.1
Medication: Lisinopril 0.3 0.4 0.9 -0.3 -0.5 -1.0
Medication: Atorvastatin 0.6 0.7 1.0 -1.0 -0.6 -0.9
Illnesses of father: High blood pressure 0.1 0.1 0.1 -0.1 -0.3 -0.3
Alcohol drinker status: Never 2.2 2.7 6.0 -1.4 -0.3 -2.4
Ever smoked 2.2 3.8 8.5 2.9 1.7 -0.1
Basal metabolic rate 0.5 2.7 5.2 0.9 1.4 -2.3
Leg fat percentage (left) 0.3 1.1 2.0 1.1 0.1 -1.4
Arm fat-free mass (left) 0.6 3.1 6.0 1.0 1.5 -2.5
Number of operations (self-reported) 0.3 0.5 0.8 0.7 0.3 -0.9
Average weekly beer plus cider intake 0.0 0.0 0.1 -0.2 0.2 0.3
Irritability 0.4 0.7 0.7 0.8 0.8 -0.8
Risk taking 2.1 3.1 6.4 2.5 1.5 0.9
Ever had prostate specific antigen (PSA) test 0.7 0.9 2.3 0.5 -1.5 -0.0
Fractured/broken bones in last 5 years 0.1 0.1 0.3 -0.1 0.5 0.3
Age started oral contraceptive pill 0.7 0.8 2.0 0.6 1.4 -0.2
Diastolic blood pressure, automated reading 0.2 0.7 1.5 0.6 -0.5 -1.2
Ever depressed for a whole week 1.5 1.9 3.9 -0.8 -2.0 -1.1
Unable to work because of sickness or disability 0.6 0.8 1.0 0.8 1.0 0.9
Commuting to job workplace: Cycle 1.3 1.6 2.3 -1.0 -1.5 -1.2
Myopia 0.5 0.7 1.3 -1.1 -0.9 0.3
Vascular/heart problems diagnosed by doctor 0.6 1.5 2.6 1.3 1.6 0.4
Cholesterol lowering medication 0.9 1.3 2.7 0.9 0.7 1.6
Medication: Omeprazole (e.g. Zanprol) 1.5 1.8 4.1 -1.2 -2.0 0.2
Pain experienced in last month 0.2 0.4 1.2 -0.1 -0.1 1.1
Supplements: Calcium 2.9 3.2 6.8 -1.6 -2.6 -0.6
Basal cell carcinoma (self-reported) 1.0 1.2 1.9 1.4 -0.7 -1.0
Heart attack/myocardial infarction (self-reported) 2.2 2.8 4.3 -2.1 -2.0 0.2
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 0.1 -0.0 0.4
Heart disease (siblings) 0.2 0.2 0.3 -0.6 -0.5 0.2
Alcohol drinker status: Previous 0.2 0.3 0.4 -0.6 0.5 -0.3
Pack years of smoking 1.0 1.5 1.7 1.1 1.2 1.3
Impedance of whole body 0.3 1.6 2.6 -1.2 -0.8 1.6
Leg fat mass (left) 0.4 1.4 3.5 0.9 0.2 -1.9
Arm predicted mass (left) 0.6 3.2 5.2 1.3 1.7 -2.3