Hub : Genes

MCEE

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Coronary 0.3160 0.1050 5.9e-03 0.009 NA -0.009 NA 0.000 1.6e-01 NA 9.9e-01 NA 3.1e-01
2 GTEx Brain Cerebellum 0.3820 0.1070 5.9e-04 -0.010 NA 0.000 NA -0.003 8.3e-01 NA 3.1e-01 NA 4.0e-01
3 GTEx Esophagus Mucosa 0.1360 0.0440 4.4e-04 0.066 NA 0.057 NA 0.058 3.4e-05 NA 1.1e-04 NA 1.0e-04
4 GTEx Muscle Skeletal 0.1003 0.0383 2.9e-03 0.059 NA 0.060 NA 0.059 2.0e-06 NA 1.7e-06 NA 2.0e-06
5 GTEx Testis 0.1720 0.0620 2.0e-03 0.104 NA 0.156 NA 0.155 2.3e-05 NA 2.0e-07 NA 2.2e-07
6 YFS Blood 0.0724 0.0153 1.2e-14 0.055 0.046 0.061 0.054 0.060 2.2e-17 7.0e-15 2.5e-19 4.7e-17 6.2e-19
7 TCGA Breast Invasive Carcinoma 0.0305 0.0153 1.1e-03 -0.001 0.012 0.005 NA 0.000 6.2e-01 1.5e-03 2.4e-02 NA 3.9e-01
8 TCGA Brain Lower Grade Glioma 0.0628 0.0280 1.2e-04 0.024 0.042 0.029 NA 0.028 9.4e-04 1.5e-05 2.9e-04 NA 3.7e-04
9 TCGA Prostate Adenocarcinoma 0.0396 0.0207 8.7e-03 0.010 0.018 0.009 NA 0.012 3.0e-02 4.8e-03 3.3e-02 NA 1.7e-02
10 TCGA Stomach Adenocarcinoma 0.1350 0.0570 6.5e-04 0.002 0.040 0.009 NA 0.001 2.3e-01 7.0e-04 7.2e-02 NA 2.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.3 0.5 3.2 -0.4 0.6 1.0 0.2 0.4 0.4 0.4 0.4 1.8 -0.0
Bipolar Disorder or Schizophrenia 0.7 1.6 4.5 0.3 0.6 1.8 -1.1 1.3 -1.3 -1.8 -0.1 2.1 -0.4
Depressed Affect (Nagel 2018) 1.3 2.8 9.4 1.7 0.5 1.7 -0.0 2.3 0.8 0.8 1.4 1.9 3.1
Depression (Nagel 2018) 0.6 0.9 4.2 1.1 -0.3 0.2 0.4 1.2 0.4 0.9 0.6 0.8 2.0
Intelligence (Savage-Jansen 2018) 1.5 4.5 16.5 -0.5 1.7 0.7 2.6 -3.0 4.1 2.7 0.6 -0.9 -0.7
Neuroticism (Nagel 2018) 1.1 2.6 9.4 1.7 0.4 2.1 -0.5 2.4 0.4 0.0 1.0 1.1 3.1
Schizophrenia (2018) 0.9 2.0 6.6 0.7 0.3 1.5 -1.5 1.4 -1.9 -2.6 -0.4 1.2 -0.7
Schizophrenia vs Biploar Disorder 1.8 2.3 6.8 -1.2 -1.2 -1.6 -2.0 -0.6 -2.6 -1.6 -1.6 -0.6 -1.1
Worry (Nagel 2018) 0.2 0.4 1.1 0.2 -0.8 0.7 -0.9 0.8 -0.4 -0.4 -0.1 0.5 1.0
Alzheimer’s Disease (in mother) 2.5 2.9 8.4 2.9 1.0 1.8 1.4 1.4 1.2 -0.1 2.5 1.5 1.7
Alzheimer’s Disease (in father) 0.7 0.8 3.2 -1.4 -0.8 -0.5 -0.6 -0.3 -0.7 -0.8 -0.8 0.0 -1.8
Alzheimer’s Disease (including proxy) 1.1 1.6 5.2 1.4 0.4 1.2 -0.7 2.0 -1.2 -2.3 0.8 0.8 -0.1
Crohns Disease (2017) 0.4 1.0 3.7 -0.1 -0.8 0.0 0.9 0.8 1.4 0.4 1.3 1.9 0.2
Irritable Bowel Disease (IBD) 0.4 1.0 6.2 -0.4 -0.4 -0.0 0.9 0.1 0.9 0.7 1.2 2.5 0.2
Ulcerative Colitis (UC) 0.3 0.5 3.3 -0.7 0.0 -0.5 0.3 -0.7 -0.0 0.5 0.4 1.8 -0.1
Major Depression (MDD) 0.7 0.9 2.4 -0.5 -1.5 0.5 -1.1 1.2 -0.5 -0.9 -1.0 0.2 0.9
Reaction Time 2.0 3.8 8.6 2.3 1.5 2.9 -0.1 2.9 -0.8 -2.7 1.8 1.5 0.0
Verbal and Numeric Reasoning (VNR) 0.9 2.2 6.7 0.6 2.2 1.7 1.5 -1.2 2.6 0.8 1.0 -0.4 -1.3
Breast Cancer 0.4 0.9 3.4 -0.8 -1.1 -1.2 -0.5 -0.1 -0.6 -0.6 0.1 -1.3 -1.8
Ovarian Cancer 0.2 0.2 0.5 0.4 -0.3 -0.3 0.4 -0.5 -0.6 -0.7 0.7 0.2 -0.2
Prostate Cancer 0.2 0.3 1.2 -0.6 1.1 -0.5 0.3 -0.0 0.3 0.3 0.1 0.8 -0.2
Age at First Birth 0.4 0.6 3.8 -0.8 -0.6 -0.4 0.1 -0.7 -0.2 -0.5 -0.2 -0.2 -1.9
Bipolar Disorder (2011) 0.5 0.5 1.8 -0.6 0.8 0.6 0.4 -0.3 0.6 0.1 0.1 1.4 -1.0
Body Mass Index (BMI) (2010) 0.8 1.2 2.3 0.4 0.9 0.6 1.5 -0.8 1.2 1.3 1.5 0.7 1.2
Coronary Artery Disease (CAD) 1.7 2.1 5.0 2.0 1.0 1.6 2.0 -0.4 1.7 0.6 2.2 0.4 0.5
Crohns Disease (2012) 1.1 1.7 5.5 -1.2 -1.9 -0.2 0.7 0.7 1.8 1.3 0.5 2.4 0.1
Mean Putamen Volume 0.3 0.4 1.8 0.4 -0.7 -1.4 0.2 -0.3 0.0 0.6 -0.1 -0.8 -0.5
Fasting Glucose 1.1 1.3 4.7 0.1 0.7 1.3 -1.1 2.2 -0.3 -1.2 0.3 1.8 0.7
HbA1C 1.2 1.4 4.3 1.0 1.5 1.0 1.1 -0.0 1.6 0.9 1.0 -0.2 2.1
HDL Cholesterol 0.9 1.5 4.3 -1.5 -0.5 -1.8 0.7 -1.4 0.8 2.1 0.0 1.3 -0.4
LDL Cholesterol 1.2 1.9 4.9 0.8 0.4 -1.0 2.2 -1.4 1.9 1.7 1.6 -0.6 1.1
Lupus 0.3 0.5 2.1 -1.4 -0.2 -0.9 0.3 -1.0 0.3 0.6 -0.1 0.4 -0.1
Neuroticism (2016) 0.6 0.9 2.6 1.3 -0.9 0.4 -1.1 1.4 -0.5 -0.3 -0.0 -0.6 1.6
Primary Biliary Cirrhosis 1.6 2.2 4.8 -1.5 -1.8 -1.9 -1.5 -0.9 -1.9 -0.7 -2.2 -0.9 -0.8
Rheumatoid Arthritis 0.8 1.2 3.9 -2.0 -0.8 -1.5 0.0 -1.4 0.1 1.3 -0.8 0.1 -0.9
Schizophrenia (2014) 0.9 2.1 4.8 -1.1 -0.4 0.3 -2.2 1.1 -2.1 -2.2 -1.3 1.4 -0.8
Triglycerides 1.0 1.7 4.6 1.1 -0.3 1.0 2.1 -0.9 2.1 0.7 1.7 -0.5 1.1
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.9 -0.6 -1.3 0.2 1.0 -1.1 0.8 0.8 0.9 1.4 0.2
Ulcerative Colitis 0.5 0.7 3.5 -0.7 0.7 -0.5 0.8 -0.8 0.4 0.8 0.6 1.9 0.1
Blood Eosinophil Count 1.6 12.3 42.9 3.7 4.3 6.5 2.1 2.8 3.9 0.8 2.9 1.4 3.2
Blood Platelet Count 0.1 1.5 3.6 -1.1 -1.0 -1.5 -1.8 1.9 -1.6 -0.4 -0.8 0.2 0.2
Blood Red Count 0.0 0.4 2.8 0.1 -1.7 -0.2 0.1 -0.4 0.3 0.3 -0.4 -0.1 -1.0
Blood White Count 0.3 2.5 5.2 2.1 1.4 1.9 0.8 2.3 2.2 0.8 1.1 -0.5 1.6
Heel T-Score 0.8 6.1 18.7 -0.4 -2.0 -1.9 2.8 -4.3 3.0 2.7 0.9 -3.1 -0.7
BMI 0.1 0.6 2.2 0.8 0.3 1.4 0.3 -0.6 0.2 -0.7 0.2 -1.5 -0.3
Height 1.1 22.0 57.0 -0.7 0.6 1.1 -5.7 7.5 -6.8 -6.0 -2.9 6.0 -1.1
Waist Hip Ratio (WHR) 0.4 2.0 9.7 1.1 0.8 -0.2 1.1 -3.1 -0.5 -0.7 0.8 -2.3 -0.7
Systolic Blood Pressure 0.5 2.5 9.6 0.4 2.0 1.0 -0.8 -0.2 -2.5 -3.1 0.2 0.5 -1.8
Smoking Status 0.6 1.3 4.0 1.5 2.0 1.8 -0.0 0.8 0.5 0.2 -0.2 0.4 1.5
Allergy or Eczema 0.4 1.0 3.8 -0.3 -1.9 -0.4 0.3 -0.7 0.4 -0.2 0.2 -1.9 -1.4
Cardiovascular Disease 0.4 1.2 4.1 1.2 1.5 1.3 -0.0 -0.2 -1.2 -2.0 0.7 -0.2 -0.0
Hypothyroidism (self reported) 0.4 1.0 3.3 -1.1 -0.1 0.3 -1.5 1.1 -0.5 0.3 -1.2 1.8 0.2
Respiratory disease 0.5 1.1 4.5 1.6 -0.2 2.1 0.7 0.4 0.9 0.1 0.5 1.3 0.9
Type 2 Diabetes (T2D) (2018) 0.8 1.5 4.3 0.6 0.4 0.8 -1.1 -0.3 -1.6 -2.1 -1.6 -1.5 -0.8
Lung FEV1/FVC ratio 0.4 1.8 3.8 1.4 1.0 -0.0 1.1 1.8 1.1 1.3 1.9 -0.3 1.9
Lung FVC 0.2 1.0 3.4 -1.6 0.1 -1.6 0.0 -1.8 0.0 0.6 -0.4 0.8 -0.9
Neuroticism 0.5 1.2 4.6 1.6 -0.1 1.5 -0.6 1.1 -0.5 -0.6 0.6 0.5 2.1
Chronotype (morning person) 0.8 1.8 5.7 -0.2 -0.1 -0.6 -2.1 0.6 -2.4 -1.8 -1.5 -0.9 0.6
Hair Pigment 0.0 0.8 2.8 -0.8 1.7 -0.7 -0.6 -0.2 -1.1 -0.7 -0.8 0.7 -0.8
Tanning 0.0 0.4 1.1 0.2 -1.0 -1.0 0.3 0.4 0.9 0.1 0.5 -0.6 -0.5
Hand grip strength (left) 0.5 1.4 5.9 -0.5 0.8 0.7 -1.0 1.8 -1.0 -1.3 -0.0 2.4 -0.0
Number of treatments/medications taken 0.6 1.1 3.1 1.4 1.1 1.8 -0.1 1.5 -0.1 -0.8 0.9 1.0 0.3
Average weekly spirits intake 1.9 2.3 5.6 2.1 1.8 1.7 -1.0 2.2 -0.9 -2.4 0.7 0.1 -0.4
Sensitivity / hurt feelings 0.8 1.4 3.5 1.0 0.1 1.2 -1.2 1.4 -1.2 -1.9 -0.7 -1.1 1.2
Frequency of depressed mood in last 2 weeks 0.6 0.8 3.6 1.2 -0.4 0.2 -0.3 1.3 -0.1 0.7 -0.2 0.5 1.9
Hearing difficulty/problems: Yes 0.6 0.8 3.2 -0.5 -1.4 -0.7 0.0 1.0 0.5 0.1 0.1 1.8 -1.2
Relative age of first facial hair 0.4 0.8 3.0 -0.6 0.5 1.1 0.1 0.6 1.2 1.0 -0.0 1.7 0.6
Other serious medical condition/disability diagnosed by doctor 1.4 1.9 3.5 -1.9 -1.8 -1.1 -1.8 0.8 -1.7 -0.7 -1.8 -0.0 -0.6
Ever used hormone-replacement therapy (HRT) 1.4 1.7 5.5 0.8 -0.7 0.6 1.8 -1.0 2.4 2.1 0.7 0.1 0.9
Ever had hysterectomy (womb removed) 0.6 0.7 1.5 -0.1 -0.8 0.6 0.6 -0.3 1.1 1.0 1.0 0.7 1.2
Systolic blood pressure, automated reading 0.1 0.4 1.1 -0.7 0.5 0.3 0.1 -0.5 -0.5 -0.7 0.3 1.0 -1.1
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 2.2 0.3 0.1 0.8 -1.1 0.5 -1.5 -1.4 -0.9 -0.0 0.7
Angina 0.5 0.6 2.3 -1.0 1.0 -0.3 0.9 -1.5 0.5 0.6 0.4 0.2 -0.2
Medication for hormone replacement therapy 1.8 2.1 4.8 1.2 1.0 -0.6 2.2 -2.0 2.0 1.6 1.5 0.1 0.2
Vitamin and mineral supplements 0.5 0.7 3.2 -0.2 1.5 -0.4 0.5 -1.0 -0.2 -0.1 -0.3 -1.8 -0.1
Supplements: Zinc 1.8 1.9 6.8 0.1 -0.0 1.5 -0.6 2.5 0.0 -0.2 1.0 2.6 1.5
Medication: Co-codamol 0.6 0.7 2.0 -0.6 -0.1 -0.7 -0.9 0.2 -1.1 -0.5 -1.3 0.2 -1.4
Medication: Metformin 0.9 1.2 3.9 0.6 -0.4 0.1 -1.1 0.4 -2.0 -1.9 -0.7 -1.5 -0.3
Diabetes (father) 0.3 0.4 2.1 0.6 0.2 0.1 -0.0 0.6 0.0 0.4 0.4 1.5 0.8
Diabetes (mother) 0.1 0.1 0.4 -0.2 -0.2 0.1 -0.1 -0.3 -0.6 -0.6 -0.4 0.4 -0.2
Severe depression (siblings) 0.9 1.1 2.4 0.1 -1.4 -0.8 0.9 -1.3 0.9 1.4 0.2 -1.6 -0.0
Pack years adult smoking proportion 1.1 1.6 8.0 0.3 2.8 1.6 -0.1 0.6 0.1 -0.7 0.7 2.1 -0.4
Impedance of leg (right) 0.1 0.6 2.2 -0.8 -0.0 -1.5 0.6 -1.2 0.3 1.1 0.1 0.1 0.4
Leg fat-free mass (left) 1.1 5.6 15.8 1.0 0.7 2.6 -2.8 3.4 -3.0 -4.0 -1.4 1.1 -0.5
Trunk fat percentage 0.1 0.5 3.1 0.8 0.5 1.8 0.6 -0.4 0.3 -0.5 0.2 -0.1 -0.4
Hand grip strength (right) 0.6 1.5 7.3 -0.3 0.8 1.0 -0.5 2.0 -0.7 -1.2 0.2 2.7 -0.2
Townsend deprivation index at recruitment 0.7 0.9 5.6 0.9 -0.0 0.3 1.1 -0.9 0.4 0.0 0.7 -2.4 0.5
Current tobacco smoking 0.6 1.1 2.9 1.4 1.7 0.6 1.3 -0.4 1.0 1.2 0.2 0.3 0.9
Average weekly fortified wine intake 0.8 1.0 4.9 -2.2 -0.1 -0.7 -1.4 0.6 0.1 0.1 -1.3 0.5 -0.4
Maternal smoking around birth 0.3 0.5 1.1 -0.5 0.7 0.5 -0.7 1.1 -0.7 -0.8 -0.0 1.0 0.0
Fed-up feelings 0.7 1.2 6.6 1.2 0.1 0.2 -0.4 1.4 -0.2 0.6 0.3 1.0 2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 1.4 1.2 0.2 -0.4 0.2 0.6 -0.2 0.2 0.2 -0.2 1.1
Relative age voice broke 0.5 0.8 1.5 -0.9 -0.4 0.0 -1.2 1.1 -1.0 -0.7 -1.0 -0.9 -0.8
Taking other prescription medications 0.2 0.2 1.0 -0.2 -1.0 -0.3 -0.4 -0.3 -0.5 0.2 -0.7 0.2 0.1
Age when periods started (menarche) 0.5 1.3 6.8 0.4 0.1 1.1 -1.1 2.6 -0.8 -0.6 -0.2 1.3 0.8
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.3 0.4 -0.6 1.2 -0.3 0.8 0.7 0.0 -0.0 -0.1 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 7.5 -0.4 -0.6 -0.9 0.2 -2.6 -0.0 0.1 -0.4 -2.7 -1.3
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 3.3 -1.2 -1.2 -1.5 0.2 -0.8 0.4 0.6 -0.6 -0.0 -1.8
Qualifications: CSEs or equivalent 0.9 1.1 3.6 -0.3 -0.2 -0.0 -1.6 1.1 -1.9 -1.6 -0.8 0.2 0.5
Serious illness, injury or assault to yourself 0.5 0.6 2.4 -0.5 -1.5 -1.4 -0.1 -0.3 0.0 0.7 -0.6 -0.3 -0.5
High blood pressure 0.5 1.5 5.2 1.0 1.1 1.3 -0.2 0.8 -1.6 -2.3 1.0 0.5 -1.2
Hayfever, allergic rhinitis or eczema 0.5 1.1 3.4 -0.6 -1.0 -0.7 1.1 -1.3 1.4 0.7 0.3 -1.8 -0.8
Multivitamins +/- minerals 0.9 1.2 5.3 -0.3 -1.2 0.4 0.1 1.2 1.2 1.2 0.8 2.3 -0.3
Stomach or abdominal pain in last month 0.3 0.3 1.6 -0.3 1.3 0.4 0.2 0.5 0.6 0.2 0.8 -0.3 0.4
Supplements: Glucosamine 0.7 0.9 2.1 -0.6 -1.5 0.5 -1.4 0.5 -0.6 -1.3 -0.9 0.4 -1.1
Diverticular disease/diverticulitis (self-reported) 1.6 1.9 5.8 0.6 -0.1 -0.1 2.4 -1.0 1.9 2.0 1.8 0.3 1.3
Medication: Atenolol 1.1 1.3 3.2 -0.6 1.8 1.6 0.9 -0.0 1.3 0.6 1.1 1.7 0.3
Medication: Levothyroxine sodium 0.6 1.1 2.9 -0.6 -1.0 -0.2 -1.7 0.3 -1.6 -1.1 -1.5 0.4 -0.7
Sitting height 1.2 8.6 21.2 0.3 0.5 1.7 -3.4 4.6 -4.1 -4.6 -1.4 3.0 -1.3
Chronic bronchitis/emphysema (father) 1.4 1.6 4.7 1.2 1.0 1.1 2.2 -1.4 1.0 -0.1 2.0 -0.3 -0.9
High blood pressure (mother) 0.3 0.4 1.3 -0.7 0.3 0.6 0.5 -1.2 0.4 -0.3 1.0 0.2 0.3
Body mass index (BMI) 0.2 0.9 4.8 1.2 0.4 2.2 0.2 -0.2 0.1 -1.0 -0.2 -1.2 -0.2
Impedance of leg (left) 0.1 0.5 2.3 -0.8 -0.1 -1.5 0.6 -0.8 0.2 1.0 0.3 0.5 0.1
Leg predicted mass (left) 1.1 5.7 16.1 1.1 0.7 2.6 -2.8 3.4 -3.0 -4.0 -1.4 1.1 -0.6
Trunk fat mass 0.2 1.1 4.6 0.8 0.7 2.1 -0.4 0.6 -0.8 -1.7 -0.4 0.4 -0.7
Waist circumference 0.4 1.6 4.8 1.2 0.8 2.1 -0.7 -0.1 -1.7 -2.2 -0.8 -1.0 -0.5
Number of incorrect matches in round 1.0 1.7 3.2 0.8 -0.8 0.1 -1.3 1.8 -1.8 -1.5 -1.3 -1.8 -0.2
Past tobacco smoking 1.0 1.8 6.5 -1.0 -1.8 -2.5 1.0 -2.1 0.3 1.4 -0.3 0.2 -0.6
Alcohol usually taken with meals 0.5 0.9 2.2 -0.9 -0.4 -1.0 -0.2 -0.6 -0.1 1.3 -1.3 1.5 -0.7
Nervous feelings 0.2 0.3 1.6 0.4 -0.7 0.3 -0.4 0.3 -0.4 -0.2 0.2 -0.3 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.5 0.8 -0.1 -0.3 -0.1 -1.1 -0.2 0.5 -0.9 -0.3 1.2
Hearing difficulty/problems with background noise 0.4 0.7 2.7 0.3 -1.6 -0.7 0.1 1.3 0.4 0.1 0.7 0.9 -0.5
Hair/balding pattern: Pattern 2 1.2 1.5 4.6 0.2 0.3 0.5 0.7 -0.9 1.7 1.8 1.1 1.2 2.2
Had menopause 1.8 2.3 9.3 -1.1 -3.0 -2.2 0.3 -1.4 0.6 2.1 -0.8 -0.5 0.2
Had other major operations 0.5 0.6 1.5 -0.5 -1.2 -0.9 0.1 -1.0 -0.5 0.0 -1.1 0.7 -0.8
Forced vital capacity (FVC) 0.3 1.1 6.1 -0.6 1.5 -0.1 -0.7 0.8 -0.6 -0.6 -0.4 2.5 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 10.0 -0.4 -0.8 -1.5 0.4 -3.2 -0.2 0.3 -0.4 -2.7 -1.6
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.9 1.3 0.3 0.7 1.0 0.3 0.7 0.5 1.7 0.4 0.5
Qualifications: None of the above 1.2 2.5 7.3 2.7 1.1 2.3 0.3 1.8 -0.3 -1.1 1.4 -0.6 2.1
Financial difficulties in last 2 years 0.3 0.4 1.1 0.5 -0.3 0.1 -0.7 1.0 -1.0 -0.8 -0.1 -0.5 0.3
Mouth/teeth dental problems 0.7 1.1 1.8 -1.2 1.2 -0.6 0.8 -1.2 1.0 1.3 0.4 1.3 0.8
Heart attack 0.8 1.0 4.1 -0.3 1.1 -0.6 1.2 -2.0 0.3 0.3 1.0 -0.1 -1.4
Allergy 0.2 0.5 1.2 -0.0 0.6 -0.1 -0.9 1.1 -1.1 -0.4 -0.3 1.1 0.2
Pain all over the body in last month 0.5 0.5 2.3 -0.7 1.5 0.0 0.3 -0.4 0.1 -0.6 0.1 -0.3 -1.4
Diabetes (self-reported) 0.9 1.4 3.6 -0.0 0.1 -0.2 -1.1 -0.4 -1.9 -1.9 -1.2 -1.6 -1.2
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.9 0.6 0.5 0.6 0.8 0.4 1.1 1.2 0.0 -0.3 1.4
Medication: Ramipril 0.7 0.9 2.2 1.2 0.8 0.3 0.5 0.2 -1.3 -1.5 1.0 -0.1 -1.1
Medication: Simvastatin 0.1 0.2 0.7 -0.2 0.3 -0.3 0.3 -0.8 0.4 0.5 0.4 0.3 0.2
Fluid intelligence score 1.0 2.2 6.6 0.9 2.0 1.7 1.7 -1.2 2.6 0.8 0.9 -1.2 -0.6
Illnesses of siblings 1.4 2.0 5.6 0.1 0.1 -0.9 -2.4 1.9 -2.2 -1.8 -1.4 -0.5 0.2
Neuroticism score 0.6 1.2 4.2 1.2 0.5 1.2 -1.0 1.4 -0.9 -0.8 0.1 0.6 2.0
Weight 0.8 3.9 11.2 0.8 0.7 2.6 -2.2 2.3 -2.6 -3.3 -1.6 0.7 -0.8
Impedance of arm (right) 0.2 1.2 2.8 -0.5 0.2 -1.4 1.2 -1.6 1.1 1.7 1.0 0.6 0.5
Arm fat percentage (right) 0.3 1.2 4.2 1.3 0.9 2.1 1.0 -1.4 0.9 -0.1 0.4 -1.1 0.2
Trunk fat-free mass 1.5 8.8 23.1 0.4 0.9 2.4 -3.8 4.2 -4.2 -4.8 -2.1 1.8 -1.0
Hip circumference 0.8 3.4 7.6 0.8 0.4 2.8 -2.1 2.6 -2.0 -2.6 -1.7 0.5 -0.3
Time employed in main current job 0.3 0.4 1.5 -0.3 -0.8 -1.0 -0.1 0.4 -0.3 0.2 -0.2 1.2 -0.2
Alcohol intake versus 10 years previously 0.4 0.6 1.7 0.7 -0.0 0.9 -0.8 0.3 -0.8 -0.2 -1.2 -0.6 1.3
Father’s age at death 0.8 1.1 2.7 0.2 -1.5 0.9 -1.1 1.7 0.6 0.7 -0.7 1.4 1.0
Worrier / anxious feelings 1.3 2.4 6.1 0.7 -1.6 0.4 -2.4 2.5 -1.7 -1.9 -1.1 -0.1 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.8 -0.9 -0.5 -0.8 -0.6 0.9 -0.7 0.3 -0.2 0.4 0.1
Falls in the last year 1.3 1.7 4.9 0.8 0.7 0.7 -1.2 2.2 -1.8 -2.2 -0.3 0.0 -1.0
Hair/balding pattern: Pattern 3 0.8 1.2 3.1 0.6 1.1 1.8 -0.5 1.5 -0.8 -1.6 0.3 -0.0 -1.2
Number of live births 0.3 0.5 1.8 -0.2 -0.2 -1.3 0.7 -0.6 0.0 1.0 0.3 0.2 0.8
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 2.8 -0.0 1.3 -0.3 -0.1 0.7 -0.3 -0.5 0.5 1.7 0.1
Pulse rate 0.5 0.8 1.9 1.3 0.8 0.4 0.3 -0.8 -1.4 -1.4 0.7 -0.5 -0.9
Happiness 1.3 1.6 4.6 2.1 0.1 1.9 -0.2 1.7 -0.2 -1.1 0.3 -0.6 1.7
Noisy workplace 0.8 1.0 4.1 0.6 0.5 1.1 -0.8 2.0 -0.7 -0.8 0.2 1.4 0.7
Qualifications: A levels/AS levels or equivalent 1.4 3.0 10.6 -1.5 1.1 0.9 1.9 -1.9 3.3 2.1 1.2 1.6 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.5 0.3 0.1 0.5 -1.5 0.7 -1.0 -1.6 -0.8 -0.6 -0.1
Mouth/teeth dental problems: Dentures 0.8 1.4 5.7 1.9 1.3 2.4 0.4 1.0 0.4 0.1 0.6 0.0 1.1
Asthma 0.2 0.4 1.9 0.2 -1.4 1.0 0.3 -0.8 0.1 -0.3 -0.2 -0.0 0.1
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.5 6.4 2.2 1.6 1.9 1.2 1.1 1.3 -0.1 1.6 0.3 2.5
Medication: Cholesterol lowering 0.3 0.5 2.3 -0.1 0.5 -0.3 0.7 -1.5 0.2 -0.1 0.5 -0.5 -1.2
Depression (self-reported) 0.5 0.7 2.9 0.4 -0.6 -1.1 -0.3 0.2 -0.8 -0.1 -0.8 -1.7 -0.7
Medication: Lansoprazole 0.2 0.2 0.6 -0.6 -0.6 -0.7 0.3 -0.8 -0.4 -0.1 -0.1 -0.6 -0.1
Prospective memory result 3.5 4.3 14.3 -0.7 -1.5 -3.1 -1.7 0.0 -3.8 -2.1 -1.9 -1.2 -1.9
Lung cancer (father) 0.4 0.5 2.0 -0.8 -0.2 -1.4 -0.0 -1.2 -0.3 0.4 -0.4 -0.6 -0.5
Illnesses of mother 0.7 0.9 2.9 1.7 1.5 0.5 0.6 1.1 0.3 -0.2 0.8 -0.5 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.4 5.1 0.2 1.6 -0.2 -1.0 1.1 -1.5 -2.3 -0.2 1.1 -0.9
Pulse wave Arterial Stiffness index 1.3 1.5 4.2 2.0 -0.2 0.6 -0.8 1.2 -1.0 -1.9 0.3 -1.8 0.1
Impedance of arm (left) 0.3 1.5 4.0 -1.1 -0.7 -1.8 1.0 -1.6 1.1 2.0 0.5 0.5 0.2
Arm fat mass (right) 0.3 1.1 5.6 1.1 0.7 2.4 -0.4 0.3 -0.7 -1.6 -0.5 -0.5 -0.1
Trunk predicted mass 1.5 8.7 23.0 0.3 0.9 2.3 -3.8 4.2 -4.2 -4.8 -2.1 1.7 -1.0
Standing height 1.5 15.1 34.9 -0.9 0.4 0.9 -5.2 5.5 -5.9 -5.4 -3.1 3.9 -1.6
Length of working week for main job 1.6 1.7 6.9 2.6 1.6 1.7 0.7 0.4 0.3 -1.1 0.9 -1.6 0.2
Exposure to tobacco smoke at home 0.7 0.7 2.0 1.1 -0.5 0.0 1.0 -1.0 -0.6 -1.0 1.4 -0.8 -0.1
Breastfed as a baby 0.8 1.0 3.9 2.0 0.1 0.5 -0.3 1.5 -1.0 -1.2 -0.1 -0.5 0.4
Tense / ‘highly strung’ 0.8 1.3 3.8 1.8 0.7 2.0 0.5 0.6 0.4 -0.3 1.1 0.4 2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 3.5 0.2 0.0 0.5 0.8 -0.4 1.6 1.6 0.7 0.3 1.9
Hair/balding pattern: Pattern 4 0.7 1.6 6.0 2.4 1.3 1.8 0.6 1.4 0.1 -0.6 1.0 -0.3 1.4
Birth weight of first child 0.4 0.7 3.2 -1.2 -1.8 -0.7 0.3 -0.8 0.4 0.8 -0.6 0.1 -0.8
Peak expiratory flow (PEF) 0.2 0.5 2.1 -0.4 0.1 -1.4 -0.6 1.0 -0.6 -0.3 -0.4 0.0 -0.8
Pulse wave reflection index 0.3 0.4 1.1 0.7 1.1 0.8 -0.1 0.9 0.5 -0.1 0.1 -0.5 0.1
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.9 0.7 -0.5 -0.2 -1.0 0.7 -1.4 -1.4 -0.7 -0.1 0.1
Loud music exposure frequency 4.0 4.4 11.7 -1.9 -2.9 -1.9 -2.9 0.6 -2.4 -0.9 -3.4 -1.1 -0.5
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 6.0 -2.0 0.1 -0.1 1.0 -1.4 2.3 2.4 0.4 2.3 0.6
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.3 0.1 -0.9 -0.1 -0.8 1.0 -0.9 -1.2 -0.4 -0.9 -0.2
Blood clot in the leg (DVT) 1.4 1.8 5.5 1.8 1.8 1.1 0.8 -0.2 0.3 0.3 1.6 0.9 2.4
Medication: Paracetamol 0.3 0.4 1.2 -0.0 0.3 0.1 -0.9 1.1 -0.5 -0.8 -0.7 -0.7 -0.6
Headache pain in last month 0.9 1.5 4.5 1.1 0.6 1.6 -0.6 2.1 -0.9 -1.1 0.3 0.7 1.9
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.7 -0.2 -0.5 -0.5 -0.1 0.0 0.3 0.8 -0.6 -0.4 1.3
Glaucoma (self-reported) 0.2 0.2 0.7 -0.1 -0.8 -0.3 -0.2 0.3 -0.6 -0.4 0.2 0.6 -0.5
Gout (self-reported) 0.5 0.7 1.5 1.2 -0.9 0.8 0.6 0.0 1.2 0.0 1.1 -0.8 0.2
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.5 -0.6 -0.5 0.1 -1.2 0.2 -0.7 0.1 -1.2 1.2 0.6
Medication: Amlodipine 1.0 1.3 3.6 0.7 1.5 1.4 0.3 1.4 0.2 -0.9 1.9 1.5 0.4
Medication: Ventolin 100micrograms inhaler 0.4 0.6 2.1 0.4 -1.4 -0.0 -0.7 0.2 -0.4 -0.3 -0.9 -1.2 -0.7
Birth weight 0.8 1.8 7.1 -1.1 -2.7 -1.6 -0.4 -1.7 -0.4 0.8 -1.4 0.5 -1.0
Chronic bronchitis/emphysema (mother) 0.6 0.7 2.1 -1.2 -1.5 -0.9 -0.4 -0.9 -0.1 0.6 -1.1 -0.2 -0.7
High blood pressure (siblings) 0.4 0.6 2.3 -0.5 -0.2 1.5 0.8 -0.0 0.8 0.4 0.7 1.0 0.1
Forced vital capacity (FVC), Best measure 0.7 2.5 5.5 -0.9 1.4 -0.2 -1.8 1.1 -2.0 -2.2 -1.3 2.4 -1.2
Body fat percentage 0.2 0.7 3.4 1.0 0.6 1.8 1.0 -0.6 0.7 -0.1 0.5 -0.4 -0.0
Leg fat percentage (right) 0.2 0.8 2.6 1.1 0.8 1.6 1.1 -0.9 0.8 0.0 0.2 -1.1 -0.0
Arm fat-free mass (right) 1.3 6.7 17.9 0.3 0.3 2.0 -3.2 3.9 -3.6 -4.2 -2.0 1.3 -1.1
Exposure to tobacco smoke outside home 0.4 0.5 2.1 -0.7 -1.1 -1.5 -0.1 -0.5 -0.8 0.1 -0.4 0.2 -0.0
Comparative body size at age 10 0.7 1.8 6.1 0.2 0.7 -0.3 2.0 -2.5 1.4 1.9 0.5 -0.9 0.9
Number of full brothers 1.0 1.3 4.1 0.5 0.3 0.4 2.0 -1.8 1.4 0.7 1.5 -0.7 -0.4
Worry too long after embarrassment 0.8 1.4 3.8 1.5 0.6 1.6 0.1 1.9 0.5 -0.6 1.1 0.3 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.7 0.1 0.3 -0.2 0.9 -0.6 1.0 1.3 0.2 -0.1 0.4
Wheeze or whistling in the chest in last year 0.6 1.1 3.8 -0.3 -0.2 0.3 -1.1 0.1 -1.5 -1.9 -1.3 -0.8 -0.9
Number of children fathered 1.7 1.9 5.2 0.4 0.3 0.6 1.5 -1.2 2.3 2.2 1.4 0.8 1.5
Reason for reducing amount of alcohol drunk: Health precaution 2.1 2.5 7.3 -0.6 1.3 1.7 -2.2 2.7 -1.5 -1.7 -1.1 1.2 -0.2
Age at first live birth 0.4 0.7 1.5 -0.3 -0.6 0.6 -1.0 0.5 -1.0 -1.2 -1.2 0.1 -0.8
Pulse wave peak to peak time 1.1 1.3 5.1 -2.3 -0.1 -0.7 0.2 -0.9 0.5 1.5 -0.8 1.8 -0.3
Health satisfaction 0.1 0.1 0.3 0.5 -0.3 0.4 0.0 -0.1 -0.4 -0.2 -0.5 0.2 0.5
Shortness of breath walking on level ground 0.8 1.0 3.1 1.8 -0.7 1.0 0.5 0.6 -0.6 -1.5 1.0 -0.7 0.8
Qualifications: College or University degree 0.3 1.0 3.2 -0.1 0.1 -0.5 1.2 -0.7 1.7 1.8 0.4 1.0 -0.7
Eye problems/disorders: None of the above 2.3 2.7 6.8 1.7 0.6 1.2 2.1 -0.5 2.6 1.9 1.7 -0.1 2.0
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.3 0.3 0.9 0.9 -0.1 1.1 -0.7 -0.9 0.7 0.0 0.2
Emphysema/chronic bronchitis 0.3 0.3 1.0 0.1 0.4 -0.3 -0.3 0.7 -0.1 1.0 -0.7 0.9 0.2
Medication for pain relief, constipation, heartburn 1.0 1.8 3.9 -1.3 -1.4 -1.6 -1.0 -1.2 -1.4 -0.5 -2.0 -1.0 -1.3
Neck or shoulder pain in last month 1.0 1.5 5.6 -0.2 0.3 0.0 -0.8 1.1 -2.1 -2.4 -0.1 -0.2 -1.6
Medication: Blood pressure 0.7 1.3 4.4 0.7 0.4 0.9 -1.0 1.7 -1.4 -2.1 0.5 0.5 -1.1
Angina (self-reported) 0.4 0.5 1.5 -0.9 1.2 -0.1 0.7 -1.2 0.3 0.5 0.4 0.2 -0.1
Migraine (self-reported) 1.5 1.8 9.3 -1.2 -0.4 -1.9 0.5 -3.0 0.5 1.5 -0.9 -0.3 -0.5
Medication: Ibuprofen 2.6 3.2 8.7 2.4 1.6 2.1 1.0 1.9 1.4 -0.0 1.8 0.5 3.0
Medication: Allopurinol 1.5 2.0 5.4 1.5 0.7 0.8 1.9 -1.4 2.3 1.3 1.6 -0.4 0.7
Medication: Omeprazole 0.6 0.7 2.8 0.3 0.1 -0.9 -0.5 0.5 -0.9 -1.4 0.2 -1.7 -0.5
Medication: Seretide 50 evohaler 0.4 0.5 1.8 -0.8 0.3 0.6 0.4 -0.3 0.8 0.8 0.3 1.3 -0.1
Mean time to correctly identify matches 1.7 3.3 8.2 2.9 1.2 2.9 1.2 2.0 0.1 -1.3 2.4 1.4 0.4
Heart disease (mother) 0.5 0.6 1.0 0.7 0.3 0.9 1.0 -0.7 1.0 1.0 1.0 0.6 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 3.2 1.0 1.3 1.5 -0.9 0.3 -0.4 -1.3 -0.8 -1.8 0.8
Whole body fat mass 0.3 1.2 5.3 1.1 0.8 2.3 -0.5 1.0 -0.8 -1.8 -0.3 0.1 -0.4
Leg fat mass (right) 0.3 1.1 4.6 1.3 0.7 2.1 -0.3 0.7 -0.7 -1.7 -0.3 -0.6 -0.3
Arm predicted mass (right) 1.4 7.1 19.2 0.4 0.6 2.1 -3.2 3.9 -3.7 -4.4 -2.0 1.2 -1.2
Pulse rate, automated reading 0.3 1.1 4.5 2.1 1.0 1.2 0.4 -0.2 -1.1 -1.3 0.7 -0.5 -0.4
Alcohol intake frequency. 0.9 2.0 13.2 0.8 -1.3 -0.6 0.4 -1.5 -0.7 -0.4 -1.1 -3.6 0.3
Comparative height size at age 10 1.4 7.9 22.4 -1.7 0.5 0.1 -4.1 2.6 -4.7 -3.4 -3.3 2.3 -1.5
Number of full sisters 0.4 0.5 2.7 0.6 -1.6 -0.4 -0.2 0.2 -0.6 -0.2 -0.3 -1.0 -0.1
Suffer from ‘nerves’ 0.1 0.2 1.1 -0.2 0.5 0.2 -0.4 0.6 -0.2 -0.3 0.2 1.1 0.1
Overall health rating 0.3 0.6 1.9 0.9 0.5 0.9 0.2 0.3 -1.0 -1.4 0.8 -0.5 0.5
Chest pain or discomfort 0.5 0.7 1.8 -0.1 0.5 0.2 1.4 -0.9 1.3 0.8 1.3 -0.1 0.4
Had major operations 0.5 0.5 1.4 0.3 -0.7 1.0 0.2 1.2 0.4 -0.5 0.5 0.7 -1.0
Age at last live birth 0.5 0.7 3.0 1.0 1.7 0.8 0.5 0.3 0.5 0.2 0.3 0.9 0.9
Family relationship satisfaction 1.0 1.3 4.7 -0.7 0.3 1.1 -1.6 2.2 -0.4 0.1 -1.6 1.0 0.3
Leg pain on walking 1.7 2.2 5.4 2.2 -0.0 1.1 -1.0 2.1 -1.7 -2.3 0.1 -0.9 1.0
Qualifications: NVQ or HND or HNC or equivalent 3.0 3.7 9.4 -0.7 -3.1 -0.7 -2.5 0.4 -2.3 -2.0 -2.4 -2.1 -0.9
Commuting to job workplace: Car/motor vehicle 0.8 0.9 3.1 0.6 -0.2 0.4 -0.8 1.7 -1.3 -1.8 0.1 -0.2 -0.4
Illness, injury, bereavement, stress in last 2 years 2.1 2.6 7.2 1.6 1.6 0.7 2.7 -1.3 2.2 1.5 2.0 0.0 0.8
Medication: Aspirin 1.2 1.6 4.4 0.1 1.9 0.8 0.9 -0.3 1.5 1.4 1.3 2.1 0.4
Supplements: Vitamin C 0.4 0.5 1.2 0.0 -1.0 -0.4 -1.1 0.5 -0.8 -0.8 -0.9 -0.2 0.5
Knee pain experienced in last month 0.2 0.3 0.7 0.8 0.8 0.6 -0.2 0.1 -0.4 -0.6 -0.4 -0.5 0.7
Hypertension (Self-reported) 0.7 1.9 6.1 1.2 1.4 1.7 -0.3 1.0 -1.7 -2.5 1.0 0.5 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 3.8 0.4 0.4 -0.1 -0.1 0.9 0.3 0.5 0.6 -0.6 2.0
Illnesses of father: Heart disease 0.4 0.5 1.2 0.5 -0.9 -0.3 0.9 -0.9 -0.2 -0.3 1.0 -1.1 0.1
Illnesses of siblings: Diabetes 1.1 1.3 3.2 1.5 0.7 1.1 1.8 -0.1 1.5 0.1 1.6 0.4 -0.9
Smoking status: Previous 1.0 1.6 4.5 0.4 1.1 2.1 -1.3 1.6 -1.0 -2.1 0.1 -0.2 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 2.5 5.2 11.6 -1.9 -0.1 -0.6 -3.1 1.2 -3.4 -3.1 -3.0 -0.0 -2.5
Whole body fat-free mass 1.4 8.1 21.9 0.6 0.8 2.5 -3.5 4.1 -3.9 -4.7 -2.0 1.6 -0.9
Leg fat-free mass (right) 1.1 5.8 16.0 0.8 0.7 2.4 -2.8 3.6 -3.1 -4.0 -1.4 1.5 -0.7
Arm fat percentage (left) 0.3 1.0 3.2 1.1 0.7 1.8 1.2 -1.3 1.0 0.1 0.5 -0.9 0.1
Average weekly red wine intake 0.6 0.9 2.5 -1.4 0.4 -0.8 -0.8 -0.4 -0.1 0.4 -1.6 0.7 -1.3
Handedness (chirality/laterality): Left-handed 0.9 1.1 3.3 -0.5 -1.8 -0.2 -1.4 -0.2 -1.2 -0.7 -1.6 -0.8 -0.2
Mood swings 1.1 1.9 4.2 2.0 1.7 1.8 -0.4 2.1 -0.5 -0.7 0.5 0.8 1.8
Loneliness, isolation 0.5 0.7 1.9 1.1 -0.4 1.3 0.1 1.1 0.4 0.2 0.6 0.2 1.4
Long-standing illness, disability or infirmity 0.8 1.3 5.5 -0.4 -1.4 -0.5 -0.4 -0.3 -1.3 -1.5 -0.7 -0.6 -2.3
Ever had bowel cancer screening 1.8 2.1 5.8 2.4 0.2 1.4 1.2 1.5 0.5 0.3 2.0 0.3 2.3
Diabetes diagnosed by doctor 0.6 1.0 2.3 0.2 0.1 -0.1 -0.8 -0.7 -1.4 -1.5 -1.2 -1.5 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.9 0.5 0.8 0.8 -0.8 1.5 -1.1 -1.7 -0.1 0.4 -0.3
Friendships satisfaction 1.1 1.4 5.3 1.3 -0.6 1.1 -0.7 1.5 0.3 1.0 -0.6 1.2 2.3
Qualifications: nursing, teaching 0.2 0.3 1.1 -0.2 0.5 0.1 0.6 -0.5 1.1 0.7 -0.2 -0.2 0.2
Commuting to job workplace: Walk 1.3 1.4 5.1 -0.6 0.7 -0.4 0.6 -1.0 1.2 2.2 -0.3 1.2 1.8
Eye problems/disorders: Cataract 0.9 1.0 2.7 -1.4 -0.6 -1.6 -0.7 -0.9 -1.2 -0.1 -0.8 0.5 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.5 0.6 -0.6 0.4 -1.0 1.1 -1.1 -1.2 -0.5 -0.3 -0.8
Medication for cholesterol 0.5 0.8 1.8 -0.3 -1.3 -0.1 -1.3 1.3 -0.9 -0.3 -1.3 -0.6 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 2.2 0.4 -0.7 0.4 0.7 0.3 0.7 0.9 0.5 0.3 1.5
Back pain experienced in last month 0.5 0.7 3.0 0.1 -0.4 -0.2 -0.9 1.7 -1.0 -1.2 -0.3 0.3 0.2
Mineral and other dietary supplements 0.3 0.5 1.6 -0.2 0.6 -0.7 0.0 -0.7 -0.9 -0.7 -0.5 -1.2 -0.4
Breast cancer (self-reported) 0.5 0.6 2.4 -0.5 -1.4 -0.3 -0.5 1.5 -0.4 0.5 -0.4 0.8 -0.1
Asthma (self-reported) 0.3 0.5 2.0 0.7 -1.1 1.4 0.4 -0.6 -0.0 -0.8 0.1 0.0 0.3
Osteoporosis (self-reported) 0.7 0.9 2.7 -1.2 -0.5 -1.0 0.6 0.3 1.1 1.6 0.5 1.1 0.5
Osteoarthritis (self-reported) 2.1 2.7 7.2 -0.4 -1.6 -1.1 -0.7 -1.3 -1.9 -1.5 -1.5 -2.2 -2.7
Medication: Aspirin 1.3 1.6 3.9 -0.2 1.7 0.4 1.1 -0.5 1.8 1.7 1.3 2.0 0.4
Medication: Gliclazide 0.2 0.3 0.9 -0.3 0.2 -0.3 0.3 -0.7 0.3 -0.2 -0.2 -0.9 -1.0
Illnesses of father: None of the above (group 1) 0.3 0.4 1.6 -0.5 -0.0 0.0 -0.7 -0.5 0.4 0.6 -1.3 -0.4 0.6
Smoking status: Current 0.5 0.8 2.6 1.3 1.6 0.5 0.9 -0.0 0.9 1.2 -0.0 0.3 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.5 2.5 0.8 0.5 -0.3 1.0 0.1 0.8 -0.3 1.6 0.4 -0.2
Whole body water mass 1.3 7.7 20.5 0.7 0.9 2.6 -3.4 4.0 -3.7 -4.5 -1.9 1.7 -0.8
Leg predicted mass (right) 1.0 5.6 15.3 0.8 0.7 2.5 -2.8 3.5 -3.0 -3.9 -1.3 1.6 -0.6
Arm fat mass (left) 0.2 1.0 4.1 0.7 0.3 2.0 -0.6 0.3 -0.8 -1.6 -0.7 -0.6 -0.5
Number of self-reported non-cancer illnesses 0.4 0.7 1.4 0.9 0.3 1.2 0.6 0.7 -0.5 -1.1 1.2 0.8 -0.4
Average weekly champagne plus white wine intake 0.5 0.7 2.6 0.2 -0.7 0.5 0.5 -0.9 1.2 1.6 0.1 0.8 1.0
Miserableness 1.0 1.8 5.9 2.4 0.9 1.3 0.1 1.1 0.6 0.2 0.8 -1.1 2.4
Guilty feelings 0.5 0.8 3.1 0.7 0.2 1.2 -0.8 1.4 -0.4 -0.5 -0.1 0.3 1.8
Wears glasses or contact lenses 0.6 0.7 1.8 -0.2 -0.3 0.1 -0.9 0.5 -1.4 -1.1 -1.0 -0.7 -1.2
Ever taken oral contraceptive pill 0.6 0.7 2.6 -0.0 1.6 0.9 0.8 -0.7 0.9 0.1 0.8 0.7 -0.3
Hearing aid user 0.3 0.3 1.0 -0.5 0.4 0.3 -0.2 0.1 0.8 0.4 -0.6 1.0 -0.5
Mother’s age at death 0.7 0.9 2.9 -1.4 -1.7 -1.0 0.3 -1.2 0.7 0.7 -0.2 0.2 -0.2
Financial situation satisfaction 2.1 2.6 7.6 1.2 -0.7 0.4 -2.2 0.7 -2.8 -2.5 -1.7 -1.3 0.7
Tinnitus: Yes, now most or all of the time 1.3 1.6 7.7 0.1 0.0 1.1 -1.3 2.8 -0.8 -1.4 0.5 1.1 0.8
Commuting to job workplace: Public transport 0.5 0.6 2.3 -1.5 -0.5 -1.3 -0.6 0.0 0.2 0.5 -0.7 -0.4 -0.6
Eye problems/disorders: Glaucoma 1.6 1.9 3.6 -1.9 -1.1 -1.6 -1.3 -0.6 -1.9 -1.1 -1.1 0.2 -1.9
Medication: Blood pressure 0.4 0.7 2.1 0.2 1.2 0.5 0.5 -0.7 -0.4 -1.2 1.0 -0.3 -1.4
Pain type(s) experienced in last month: Hip pain 1.6 2.0 5.6 -1.5 -2.4 -1.2 -1.5 0.7 -1.2 -0.8 -1.5 -0.6 -1.9
Supplements: Fish oil (including cod liver oil) 0.2 0.3 1.4 0.1 -1.2 0.3 -0.3 0.3 0.6 0.6 -0.3 0.3 0.2
High cholesterol (Self-reported) 0.4 0.7 1.7 1.3 0.7 1.0 0.5 0.9 0.6 -0.6 1.3 0.2 0.3
Medication: Bendroflumethiazide 0.6 0.9 2.6 0.0 1.0 0.8 -0.1 -1.4 -1.2 -1.6 -0.5 -0.0 -0.9
Medication: Paracetamol 0.4 0.6 1.7 0.7 0.5 0.5 -0.7 1.3 -0.6 -1.2 0.0 -0.6 -0.7
Medication: Lisinopril 1.3 1.7 5.3 0.1 -0.4 1.0 -1.6 1.6 -1.7 -2.3 -0.4 -0.7 -1.2
Medication: Atorvastatin 0.4 0.5 1.1 0.9 0.9 0.8 1.1 -0.5 0.2 -0.8 1.1 -0.2 0.1
Illnesses of father: High blood pressure 0.2 0.2 0.8 -0.7 0.1 -0.9 -0.6 -0.3 -0.3 0.1 -0.6 0.0 -0.4
Alcohol drinker status: Never 3.0 3.5 10.0 -2.9 -1.6 -2.0 -1.8 -1.6 -1.8 -0.0 -3.2 -1.0 -0.4
Ever smoked 1.4 2.4 8.9 2.1 1.8 3.0 0.1 1.9 0.9 -0.6 1.1 0.3 1.1
Basal metabolic rate 1.3 7.3 20.3 0.7 0.9 2.7 -3.3 3.8 -3.6 -4.5 -1.9 1.4 -0.8
Leg fat percentage (left) 0.2 0.7 2.6 1.0 0.6 1.6 1.1 -0.8 0.8 -0.0 0.2 -0.8 -0.3
Arm fat-free mass (left) 1.5 7.6 19.3 0.6 0.5 2.5 -3.5 4.0 -3.8 -4.4 -2.2 1.4 -0.8
Number of operations (self-reported) 0.3 0.5 2.5 -0.8 -1.6 0.0 -0.4 0.7 0.4 0.4 -0.7 0.4 -0.3
Average weekly beer plus cider intake 0.7 1.0 2.2 1.5 1.2 1.1 0.6 0.5 0.4 -0.4 1.4 0.1 1.4
Irritability 1.4 2.4 8.6 2.9 1.9 2.5 0.7 0.8 0.3 -0.4 1.4 0.3 1.6
Risk taking 0.8 1.1 3.1 1.0 1.2 1.2 0.5 0.7 0.5 0.0 0.7 1.8 1.7
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.8 -0.1 0.5 -0.1 0.4 -0.1 0.0 -0.1 0.9 0.1 -0.3
Fractured/broken bones in last 5 years 0.2 0.3 1.0 0.4 0.7 0.2 -0.4 0.6 -0.4 0.2 -0.3 0.8 1.0
Age started oral contraceptive pill 1.0 1.3 3.8 -1.4 -1.0 -0.3 -1.9 0.7 -1.2 0.1 -1.7 1.0 -0.2
Diastolic blood pressure, automated reading 0.5 1.5 4.0 1.4 1.3 2.0 1.4 -0.1 1.2 -0.4 1.8 -0.2 -0.2
Ever depressed for a whole week 0.5 0.6 3.0 0.3 -0.6 -0.3 0.1 0.5 -0.8 -1.3 0.4 -0.4 -1.7
Unable to work because of sickness or disability 1.2 1.6 3.5 1.5 1.1 1.2 1.9 -0.1 1.6 1.4 1.3 -0.0 1.2
Commuting to job workplace: Cycle 0.3 0.4 0.7 0.7 -0.6 -0.6 0.0 0.6 -0.7 -0.8 0.3 -0.8 -0.5
Myopia 0.1 0.2 0.8 -0.5 0.1 -0.6 0.7 -0.2 0.1 0.2 0.9 -0.2 -0.2
Vascular/heart problems diagnosed by doctor 0.4 1.2 3.0 -0.8 -1.5 -1.2 -0.4 -0.1 1.2 1.7 -1.2 -0.6 1.3
Cholesterol lowering medication 0.2 0.4 0.9 0.5 0.3 0.3 0.1 0.9 0.4 0.2 0.6 0.9 1.0
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 5.8 0.5 -0.3 -1.1 0.1 -0.5 -0.8 -1.2 0.5 -2.4 -0.5
Pain experienced in last month 0.6 1.1 3.3 -1.0 -0.7 -1.5 0.6 -1.8 0.4 1.3 -0.5 -0.1 -1.1
Supplements: Calcium 0.8 0.8 2.5 0.3 -0.3 -0.6 -0.9 0.6 -1.4 -1.6 -0.3 -1.1 -1.0
Basal cell carcinoma (self-reported) 0.5 0.5 1.7 1.3 -0.1 0.7 1.0 -0.0 0.7 0.1 0.9 -0.8 0.5
Heart attack/myocardial infarction (self-reported) 0.8 1.0 4.0 -0.1 0.9 -0.7 1.2 -2.0 0.3 0.3 1.0 -0.3 -1.3
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 5.4 1.5 1.6 1.0 1.1 -0.6 0.8 0.8 1.7 1.2 2.3
Heart disease (siblings) 1.0 1.2 4.0 0.2 0.3 -0.2 1.8 -2.0 1.1 1.5 0.9 0.7 -0.3
Alcohol drinker status: Previous 0.7 0.8 2.3 1.2 0.5 0.7 -0.5 0.4 -1.1 -1.5 -0.8 -0.8 -0.8
Pack years of smoking 1.1 1.6 6.4 -0.1 2.5 1.5 -0.2 0.5 -0.1 -0.7 0.5 2.2 -1.0
Impedance of whole body 0.2 1.0 2.6 -0.9 -0.5 -1.6 0.9 -1.1 0.9 1.6 0.6 0.7 0.2
Leg fat mass (left) 0.3 1.2 4.5 1.3 0.6 2.1 -0.2 0.5 -0.8 -1.8 -0.2 -0.6 -0.7
Arm predicted mass (left) 1.6 8.0 20.7 0.8 0.9 3.0 -3.4 4.2 -3.7 -4.5 -2.0 1.4 -0.7