Hub : Genes

MCEE

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Coronary	0.3160	0.1050	5.9e-03	0.009	NA	-0.009	NA	0.000	1.6e-01	NA	9.9e-01	NA	3.1e-01
2	GTEx	Brain Cerebellum	0.3820	0.1070	5.9e-04	-0.010	NA	0.000	NA	-0.003	8.3e-01	NA	3.1e-01	NA	4.0e-01
3	GTEx	Esophagus Mucosa	0.1360	0.0440	4.4e-04	0.066	NA	0.057	NA	0.058	3.4e-05	NA	1.1e-04	NA	1.0e-04
4	GTEx	Muscle Skeletal	0.1003	0.0383	2.9e-03	0.059	NA	0.060	NA	0.059	2.0e-06	NA	1.7e-06	NA	2.0e-06
5	GTEx	Testis	0.1720	0.0620	2.0e-03	0.104	NA	0.156	NA	0.155	2.3e-05	NA	2.0e-07	NA	2.2e-07
6	YFS	Blood	0.0724	0.0153	1.2e-14	0.055	0.046	0.061	0.054	0.060	2.2e-17	7.0e-15	2.5e-19	4.7e-17	6.2e-19
7	TCGA	Breast Invasive Carcinoma	0.0305	0.0153	1.1e-03	-0.001	0.012	0.005	NA	0.000	6.2e-01	1.5e-03	2.4e-02	NA	3.9e-01
8	TCGA	Brain Lower Grade Glioma	0.0628	0.0280	1.2e-04	0.024	0.042	0.029	NA	0.028	9.4e-04	1.5e-05	2.9e-04	NA	3.7e-04
9	TCGA	Prostate Adenocarcinoma	0.0396	0.0207	8.7e-03	0.010	0.018	0.009	NA	0.012	3.0e-02	4.8e-03	3.3e-02	NA	1.7e-02
10	TCGA	Stomach Adenocarcinoma	0.1350	0.0570	6.5e-04	0.002	0.040	0.009	NA	0.001	2.3e-01	7.0e-04	7.2e-02	NA	2.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.3	0.5	3.2	-0.4	0.6	1.0	0.2	0.4	0.4	0.4	0.4	1.8	-0.0
Bipolar Disorder or Schizophrenia	0.7	1.6	4.5	0.3	0.6	1.8	-1.1	1.3	-1.3	-1.8	-0.1	2.1	-0.4
Depressed Affect (Nagel 2018)	1.3	2.8	9.4	1.7	0.5	1.7	-0.0	2.3	0.8	0.8	1.4	1.9	3.1
Depression (Nagel 2018)	0.6	0.9	4.2	1.1	-0.3	0.2	0.4	1.2	0.4	0.9	0.6	0.8	2.0
Intelligence (Savage-Jansen 2018)	1.5	4.5	16.5	-0.5	1.7	0.7	2.6	-3.0	4.1	2.7	0.6	-0.9	-0.7
Neuroticism (Nagel 2018)	1.1	2.6	9.4	1.7	0.4	2.1	-0.5	2.4	0.4	0.0	1.0	1.1	3.1
Schizophrenia (2018)	0.9	2.0	6.6	0.7	0.3	1.5	-1.5	1.4	-1.9	-2.6	-0.4	1.2	-0.7
Schizophrenia vs Biploar Disorder	1.8	2.3	6.8	-1.2	-1.2	-1.6	-2.0	-0.6	-2.6	-1.6	-1.6	-0.6	-1.1
Worry (Nagel 2018)	0.2	0.4	1.1	0.2	-0.8	0.7	-0.9	0.8	-0.4	-0.4	-0.1	0.5	1.0
Alzheimer’s Disease (in mother)	2.5	2.9	8.4	2.9	1.0	1.8	1.4	1.4	1.2	-0.1	2.5	1.5	1.7
Alzheimer’s Disease (in father)	0.7	0.8	3.2	-1.4	-0.8	-0.5	-0.6	-0.3	-0.7	-0.8	-0.8	0.0	-1.8
Alzheimer’s Disease (including proxy)	1.1	1.6	5.2	1.4	0.4	1.2	-0.7	2.0	-1.2	-2.3	0.8	0.8	-0.1
Crohns Disease (2017)	0.4	1.0	3.7	-0.1	-0.8	0.0	0.9	0.8	1.4	0.4	1.3	1.9	0.2
Irritable Bowel Disease (IBD)	0.4	1.0	6.2	-0.4	-0.4	-0.0	0.9	0.1	0.9	0.7	1.2	2.5	0.2
Ulcerative Colitis (UC)	0.3	0.5	3.3	-0.7	0.0	-0.5	0.3	-0.7	-0.0	0.5	0.4	1.8	-0.1
Major Depression (MDD)	0.7	0.9	2.4	-0.5	-1.5	0.5	-1.1	1.2	-0.5	-0.9	-1.0	0.2	0.9
Reaction Time	2.0	3.8	8.6	2.3	1.5	2.9	-0.1	2.9	-0.8	-2.7	1.8	1.5	0.0
Verbal and Numeric Reasoning (VNR)	0.9	2.2	6.7	0.6	2.2	1.7	1.5	-1.2	2.6	0.8	1.0	-0.4	-1.3
Breast Cancer	0.4	0.9	3.4	-0.8	-1.1	-1.2	-0.5	-0.1	-0.6	-0.6	0.1	-1.3	-1.8
Ovarian Cancer	0.2	0.2	0.5	0.4	-0.3	-0.3	0.4	-0.5	-0.6	-0.7	0.7	0.2	-0.2
Prostate Cancer	0.2	0.3	1.2	-0.6	1.1	-0.5	0.3	-0.0	0.3	0.3	0.1	0.8	-0.2
Age at First Birth	0.4	0.6	3.8	-0.8	-0.6	-0.4	0.1	-0.7	-0.2	-0.5	-0.2	-0.2	-1.9
Bipolar Disorder (2011)	0.5	0.5	1.8	-0.6	0.8	0.6	0.4	-0.3	0.6	0.1	0.1	1.4	-1.0
Body Mass Index (BMI) (2010)	0.8	1.2	2.3	0.4	0.9	0.6	1.5	-0.8	1.2	1.3	1.5	0.7	1.2
Coronary Artery Disease (CAD)	1.7	2.1	5.0	2.0	1.0	1.6	2.0	-0.4	1.7	0.6	2.2	0.4	0.5
Crohns Disease (2012)	1.1	1.7	5.5	-1.2	-1.9	-0.2	0.7	0.7	1.8	1.3	0.5	2.4	0.1
Mean Putamen Volume	0.3	0.4	1.8	0.4	-0.7	-1.4	0.2	-0.3	0.0	0.6	-0.1	-0.8	-0.5
Fasting Glucose	1.1	1.3	4.7	0.1	0.7	1.3	-1.1	2.2	-0.3	-1.2	0.3	1.8	0.7
HbA1C	1.2	1.4	4.3	1.0	1.5	1.0	1.1	-0.0	1.6	0.9	1.0	-0.2	2.1
HDL Cholesterol	0.9	1.5	4.3	-1.5	-0.5	-1.8	0.7	-1.4	0.8	2.1	0.0	1.3	-0.4
LDL Cholesterol	1.2	1.9	4.9	0.8	0.4	-1.0	2.2	-1.4	1.9	1.7	1.6	-0.6	1.1
Lupus	0.3	0.5	2.1	-1.4	-0.2	-0.9	0.3	-1.0	0.3	0.6	-0.1	0.4	-0.1
Neuroticism (2016)	0.6	0.9	2.6	1.3	-0.9	0.4	-1.1	1.4	-0.5	-0.3	-0.0	-0.6	1.6
Primary Biliary Cirrhosis	1.6	2.2	4.8	-1.5	-1.8	-1.9	-1.5	-0.9	-1.9	-0.7	-2.2	-0.9	-0.8
Rheumatoid Arthritis	0.8	1.2	3.9	-2.0	-0.8	-1.5	0.0	-1.4	0.1	1.3	-0.8	0.1	-0.9
Schizophrenia (2014)	0.9	2.1	4.8	-1.1	-0.4	0.3	-2.2	1.1	-2.1	-2.2	-1.3	1.4	-0.8
Triglycerides	1.0	1.7	4.6	1.1	-0.3	1.0	2.1	-0.9	2.1	0.7	1.7	-0.5	1.1
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.9	-0.6	-1.3	0.2	1.0	-1.1	0.8	0.8	0.9	1.4	0.2
Ulcerative Colitis	0.5	0.7	3.5	-0.7	0.7	-0.5	0.8	-0.8	0.4	0.8	0.6	1.9	0.1
Blood Eosinophil Count	1.6	12.3	42.9	3.7	4.3	6.5	2.1	2.8	3.9	0.8	2.9	1.4	3.2
Blood Platelet Count	0.1	1.5	3.6	-1.1	-1.0	-1.5	-1.8	1.9	-1.6	-0.4	-0.8	0.2	0.2
Blood Red Count	0.0	0.4	2.8	0.1	-1.7	-0.2	0.1	-0.4	0.3	0.3	-0.4	-0.1	-1.0
Blood White Count	0.3	2.5	5.2	2.1	1.4	1.9	0.8	2.3	2.2	0.8	1.1	-0.5	1.6
Heel T-Score	0.8	6.1	18.7	-0.4	-2.0	-1.9	2.8	-4.3	3.0	2.7	0.9	-3.1	-0.7
BMI	0.1	0.6	2.2	0.8	0.3	1.4	0.3	-0.6	0.2	-0.7	0.2	-1.5	-0.3
Height	1.1	22.0	57.0	-0.7	0.6	1.1	-5.7	7.5	-6.8	-6.0	-2.9	6.0	-1.1
Waist Hip Ratio (WHR)	0.4	2.0	9.7	1.1	0.8	-0.2	1.1	-3.1	-0.5	-0.7	0.8	-2.3	-0.7
Systolic Blood Pressure	0.5	2.5	9.6	0.4	2.0	1.0	-0.8	-0.2	-2.5	-3.1	0.2	0.5	-1.8
Smoking Status	0.6	1.3	4.0	1.5	2.0	1.8	-0.0	0.8	0.5	0.2	-0.2	0.4	1.5
Allergy or Eczema	0.4	1.0	3.8	-0.3	-1.9	-0.4	0.3	-0.7	0.4	-0.2	0.2	-1.9	-1.4
Cardiovascular Disease	0.4	1.2	4.1	1.2	1.5	1.3	-0.0	-0.2	-1.2	-2.0	0.7	-0.2	-0.0
Hypothyroidism (self reported)	0.4	1.0	3.3	-1.1	-0.1	0.3	-1.5	1.1	-0.5	0.3	-1.2	1.8	0.2
Respiratory disease	0.5	1.1	4.5	1.6	-0.2	2.1	0.7	0.4	0.9	0.1	0.5	1.3	0.9
Type 2 Diabetes (T2D) (2018)	0.8	1.5	4.3	0.6	0.4	0.8	-1.1	-0.3	-1.6	-2.1	-1.6	-1.5	-0.8
Lung FEV1/FVC ratio	0.4	1.8	3.8	1.4	1.0	-0.0	1.1	1.8	1.1	1.3	1.9	-0.3	1.9
Lung FVC	0.2	1.0	3.4	-1.6	0.1	-1.6	0.0	-1.8	0.0	0.6	-0.4	0.8	-0.9
Neuroticism	0.5	1.2	4.6	1.6	-0.1	1.5	-0.6	1.1	-0.5	-0.6	0.6	0.5	2.1
Chronotype (morning person)	0.8	1.8	5.7	-0.2	-0.1	-0.6	-2.1	0.6	-2.4	-1.8	-1.5	-0.9	0.6
Hair Pigment	0.0	0.8	2.8	-0.8	1.7	-0.7	-0.6	-0.2	-1.1	-0.7	-0.8	0.7	-0.8
Tanning	0.0	0.4	1.1	0.2	-1.0	-1.0	0.3	0.4	0.9	0.1	0.5	-0.6	-0.5
Hand grip strength (left)	0.5	1.4	5.9	-0.5	0.8	0.7	-1.0	1.8	-1.0	-1.3	-0.0	2.4	-0.0
Number of treatments/medications taken	0.6	1.1	3.1	1.4	1.1	1.8	-0.1	1.5	-0.1	-0.8	0.9	1.0	0.3
Average weekly spirits intake	1.9	2.3	5.6	2.1	1.8	1.7	-1.0	2.2	-0.9	-2.4	0.7	0.1	-0.4
Sensitivity / hurt feelings	0.8	1.4	3.5	1.0	0.1	1.2	-1.2	1.4	-1.2	-1.9	-0.7	-1.1	1.2
Frequency of depressed mood in last 2 weeks	0.6	0.8	3.6	1.2	-0.4	0.2	-0.3	1.3	-0.1	0.7	-0.2	0.5	1.9
Hearing difficulty/problems: Yes	0.6	0.8	3.2	-0.5	-1.4	-0.7	0.0	1.0	0.5	0.1	0.1	1.8	-1.2
Relative age of first facial hair	0.4	0.8	3.0	-0.6	0.5	1.1	0.1	0.6	1.2	1.0	-0.0	1.7	0.6
Other serious medical condition/disability diagnosed by doctor	1.4	1.9	3.5	-1.9	-1.8	-1.1	-1.8	0.8	-1.7	-0.7	-1.8	-0.0	-0.6
Ever used hormone-replacement therapy (HRT)	1.4	1.7	5.5	0.8	-0.7	0.6	1.8	-1.0	2.4	2.1	0.7	0.1	0.9
Ever had hysterectomy (womb removed)	0.6	0.7	1.5	-0.1	-0.8	0.6	0.6	-0.3	1.1	1.0	1.0	0.7	1.2
Systolic blood pressure, automated reading	0.1	0.4	1.1	-0.7	0.5	0.3	0.1	-0.5	-0.5	-0.7	0.3	1.0	-1.1
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.2	0.3	0.1	0.8	-1.1	0.5	-1.5	-1.4	-0.9	-0.0	0.7
Angina	0.5	0.6	2.3	-1.0	1.0	-0.3	0.9	-1.5	0.5	0.6	0.4	0.2	-0.2
Medication for hormone replacement therapy	1.8	2.1	4.8	1.2	1.0	-0.6	2.2	-2.0	2.0	1.6	1.5	0.1	0.2
Vitamin and mineral supplements	0.5	0.7	3.2	-0.2	1.5	-0.4	0.5	-1.0	-0.2	-0.1	-0.3	-1.8	-0.1
Supplements: Zinc	1.8	1.9	6.8	0.1	-0.0	1.5	-0.6	2.5	0.0	-0.2	1.0	2.6	1.5
Medication: Co-codamol	0.6	0.7	2.0	-0.6	-0.1	-0.7	-0.9	0.2	-1.1	-0.5	-1.3	0.2	-1.4
Medication: Metformin	0.9	1.2	3.9	0.6	-0.4	0.1	-1.1	0.4	-2.0	-1.9	-0.7	-1.5	-0.3
Diabetes (father)	0.3	0.4	2.1	0.6	0.2	0.1	-0.0	0.6	0.0	0.4	0.4	1.5	0.8
Diabetes (mother)	0.1	0.1	0.4	-0.2	-0.2	0.1	-0.1	-0.3	-0.6	-0.6	-0.4	0.4	-0.2
Severe depression (siblings)	0.9	1.1	2.4	0.1	-1.4	-0.8	0.9	-1.3	0.9	1.4	0.2	-1.6	-0.0
Pack years adult smoking proportion	1.1	1.6	8.0	0.3	2.8	1.6	-0.1	0.6	0.1	-0.7	0.7	2.1	-0.4
Impedance of leg (right)	0.1	0.6	2.2	-0.8	-0.0	-1.5	0.6	-1.2	0.3	1.1	0.1	0.1	0.4
Leg fat-free mass (left)	1.1	5.6	15.8	1.0	0.7	2.6	-2.8	3.4	-3.0	-4.0	-1.4	1.1	-0.5
Trunk fat percentage	0.1	0.5	3.1	0.8	0.5	1.8	0.6	-0.4	0.3	-0.5	0.2	-0.1	-0.4
Hand grip strength (right)	0.6	1.5	7.3	-0.3	0.8	1.0	-0.5	2.0	-0.7	-1.2	0.2	2.7	-0.2
Townsend deprivation index at recruitment	0.7	0.9	5.6	0.9	-0.0	0.3	1.1	-0.9	0.4	0.0	0.7	-2.4	0.5
Current tobacco smoking	0.6	1.1	2.9	1.4	1.7	0.6	1.3	-0.4	1.0	1.2	0.2	0.3	0.9
Average weekly fortified wine intake	0.8	1.0	4.9	-2.2	-0.1	-0.7	-1.4	0.6	0.1	0.1	-1.3	0.5	-0.4
Maternal smoking around birth	0.3	0.5	1.1	-0.5	0.7	0.5	-0.7	1.1	-0.7	-0.8	-0.0	1.0	0.0
Fed-up feelings	0.7	1.2	6.6	1.2	0.1	0.2	-0.4	1.4	-0.2	0.6	0.3	1.0	2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.4	1.2	0.2	-0.4	0.2	0.6	-0.2	0.2	0.2	-0.2	1.1
Relative age voice broke	0.5	0.8	1.5	-0.9	-0.4	0.0	-1.2	1.1	-1.0	-0.7	-1.0	-0.9	-0.8
Taking other prescription medications	0.2	0.2	1.0	-0.2	-1.0	-0.3	-0.4	-0.3	-0.5	0.2	-0.7	0.2	0.1
Age when periods started (menarche)	0.5	1.3	6.8	0.4	0.1	1.1	-1.1	2.6	-0.8	-0.6	-0.2	1.3	0.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.3	0.4	-0.6	1.2	-0.3	0.8	0.7	0.0	-0.0	-0.1	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	7.5	-0.4	-0.6	-0.9	0.2	-2.6	-0.0	0.1	-0.4	-2.7	-1.3
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.3	-1.2	-1.2	-1.5	0.2	-0.8	0.4	0.6	-0.6	-0.0	-1.8
Qualifications: CSEs or equivalent	0.9	1.1	3.6	-0.3	-0.2	-0.0	-1.6	1.1	-1.9	-1.6	-0.8	0.2	0.5
Serious illness, injury or assault to yourself	0.5	0.6	2.4	-0.5	-1.5	-1.4	-0.1	-0.3	0.0	0.7	-0.6	-0.3	-0.5
High blood pressure	0.5	1.5	5.2	1.0	1.1	1.3	-0.2	0.8	-1.6	-2.3	1.0	0.5	-1.2
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.4	-0.6	-1.0	-0.7	1.1	-1.3	1.4	0.7	0.3	-1.8	-0.8
Multivitamins +/- minerals	0.9	1.2	5.3	-0.3	-1.2	0.4	0.1	1.2	1.2	1.2	0.8	2.3	-0.3
Stomach or abdominal pain in last month	0.3	0.3	1.6	-0.3	1.3	0.4	0.2	0.5	0.6	0.2	0.8	-0.3	0.4
Supplements: Glucosamine	0.7	0.9	2.1	-0.6	-1.5	0.5	-1.4	0.5	-0.6	-1.3	-0.9	0.4	-1.1
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	5.8	0.6	-0.1	-0.1	2.4	-1.0	1.9	2.0	1.8	0.3	1.3
Medication: Atenolol	1.1	1.3	3.2	-0.6	1.8	1.6	0.9	-0.0	1.3	0.6	1.1	1.7	0.3
Medication: Levothyroxine sodium	0.6	1.1	2.9	-0.6	-1.0	-0.2	-1.7	0.3	-1.6	-1.1	-1.5	0.4	-0.7
Sitting height	1.2	8.6	21.2	0.3	0.5	1.7	-3.4	4.6	-4.1	-4.6	-1.4	3.0	-1.3
Chronic bronchitis/emphysema (father)	1.4	1.6	4.7	1.2	1.0	1.1	2.2	-1.4	1.0	-0.1	2.0	-0.3	-0.9
High blood pressure (mother)	0.3	0.4	1.3	-0.7	0.3	0.6	0.5	-1.2	0.4	-0.3	1.0	0.2	0.3
Body mass index (BMI)	0.2	0.9	4.8	1.2	0.4	2.2	0.2	-0.2	0.1	-1.0	-0.2	-1.2	-0.2
Impedance of leg (left)	0.1	0.5	2.3	-0.8	-0.1	-1.5	0.6	-0.8	0.2	1.0	0.3	0.5	0.1
Leg predicted mass (left)	1.1	5.7	16.1	1.1	0.7	2.6	-2.8	3.4	-3.0	-4.0	-1.4	1.1	-0.6
Trunk fat mass	0.2	1.1	4.6	0.8	0.7	2.1	-0.4	0.6	-0.8	-1.7	-0.4	0.4	-0.7
Waist circumference	0.4	1.6	4.8	1.2	0.8	2.1	-0.7	-0.1	-1.7	-2.2	-0.8	-1.0	-0.5
Number of incorrect matches in round	1.0	1.7	3.2	0.8	-0.8	0.1	-1.3	1.8	-1.8	-1.5	-1.3	-1.8	-0.2
Past tobacco smoking	1.0	1.8	6.5	-1.0	-1.8	-2.5	1.0	-2.1	0.3	1.4	-0.3	0.2	-0.6
Alcohol usually taken with meals	0.5	0.9	2.2	-0.9	-0.4	-1.0	-0.2	-0.6	-0.1	1.3	-1.3	1.5	-0.7
Nervous feelings	0.2	0.3	1.6	0.4	-0.7	0.3	-0.4	0.3	-0.4	-0.2	0.2	-0.3	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.5	0.8	-0.1	-0.3	-0.1	-1.1	-0.2	0.5	-0.9	-0.3	1.2
Hearing difficulty/problems with background noise	0.4	0.7	2.7	0.3	-1.6	-0.7	0.1	1.3	0.4	0.1	0.7	0.9	-0.5
Hair/balding pattern: Pattern 2	1.2	1.5	4.6	0.2	0.3	0.5	0.7	-0.9	1.7	1.8	1.1	1.2	2.2
Had menopause	1.8	2.3	9.3	-1.1	-3.0	-2.2	0.3	-1.4	0.6	2.1	-0.8	-0.5	0.2
Had other major operations	0.5	0.6	1.5	-0.5	-1.2	-0.9	0.1	-1.0	-0.5	0.0	-1.1	0.7	-0.8
Forced vital capacity (FVC)	0.3	1.1	6.1	-0.6	1.5	-0.1	-0.7	0.8	-0.6	-0.6	-0.4	2.5	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	10.0	-0.4	-0.8	-1.5	0.4	-3.2	-0.2	0.3	-0.4	-2.7	-1.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.9	1.3	0.3	0.7	1.0	0.3	0.7	0.5	1.7	0.4	0.5
Qualifications: None of the above	1.2	2.5	7.3	2.7	1.1	2.3	0.3	1.8	-0.3	-1.1	1.4	-0.6	2.1
Financial difficulties in last 2 years	0.3	0.4	1.1	0.5	-0.3	0.1	-0.7	1.0	-1.0	-0.8	-0.1	-0.5	0.3
Mouth/teeth dental problems	0.7	1.1	1.8	-1.2	1.2	-0.6	0.8	-1.2	1.0	1.3	0.4	1.3	0.8
Heart attack	0.8	1.0	4.1	-0.3	1.1	-0.6	1.2	-2.0	0.3	0.3	1.0	-0.1	-1.4
Allergy	0.2	0.5	1.2	-0.0	0.6	-0.1	-0.9	1.1	-1.1	-0.4	-0.3	1.1	0.2
Pain all over the body in last month	0.5	0.5	2.3	-0.7	1.5	0.0	0.3	-0.4	0.1	-0.6	0.1	-0.3	-1.4
Diabetes (self-reported)	0.9	1.4	3.6	-0.0	0.1	-0.2	-1.1	-0.4	-1.9	-1.9	-1.2	-1.6	-1.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.9	0.6	0.5	0.6	0.8	0.4	1.1	1.2	0.0	-0.3	1.4
Medication: Ramipril	0.7	0.9	2.2	1.2	0.8	0.3	0.5	0.2	-1.3	-1.5	1.0	-0.1	-1.1
Medication: Simvastatin	0.1	0.2	0.7	-0.2	0.3	-0.3	0.3	-0.8	0.4	0.5	0.4	0.3	0.2
Fluid intelligence score	1.0	2.2	6.6	0.9	2.0	1.7	1.7	-1.2	2.6	0.8	0.9	-1.2	-0.6
Illnesses of siblings	1.4	2.0	5.6	0.1	0.1	-0.9	-2.4	1.9	-2.2	-1.8	-1.4	-0.5	0.2
Neuroticism score	0.6	1.2	4.2	1.2	0.5	1.2	-1.0	1.4	-0.9	-0.8	0.1	0.6	2.0
Weight	0.8	3.9	11.2	0.8	0.7	2.6	-2.2	2.3	-2.6	-3.3	-1.6	0.7	-0.8
Impedance of arm (right)	0.2	1.2	2.8	-0.5	0.2	-1.4	1.2	-1.6	1.1	1.7	1.0	0.6	0.5
Arm fat percentage (right)	0.3	1.2	4.2	1.3	0.9	2.1	1.0	-1.4	0.9	-0.1	0.4	-1.1	0.2
Trunk fat-free mass	1.5	8.8	23.1	0.4	0.9	2.4	-3.8	4.2	-4.2	-4.8	-2.1	1.8	-1.0
Hip circumference	0.8	3.4	7.6	0.8	0.4	2.8	-2.1	2.6	-2.0	-2.6	-1.7	0.5	-0.3
Time employed in main current job	0.3	0.4	1.5	-0.3	-0.8	-1.0	-0.1	0.4	-0.3	0.2	-0.2	1.2	-0.2
Alcohol intake versus 10 years previously	0.4	0.6	1.7	0.7	-0.0	0.9	-0.8	0.3	-0.8	-0.2	-1.2	-0.6	1.3
Father’s age at death	0.8	1.1	2.7	0.2	-1.5	0.9	-1.1	1.7	0.6	0.7	-0.7	1.4	1.0
Worrier / anxious feelings	1.3	2.4	6.1	0.7	-1.6	0.4	-2.4	2.5	-1.7	-1.9	-1.1	-0.1	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.8	-0.9	-0.5	-0.8	-0.6	0.9	-0.7	0.3	-0.2	0.4	0.1
Falls in the last year	1.3	1.7	4.9	0.8	0.7	0.7	-1.2	2.2	-1.8	-2.2	-0.3	0.0	-1.0
Hair/balding pattern: Pattern 3	0.8	1.2	3.1	0.6	1.1	1.8	-0.5	1.5	-0.8	-1.6	0.3	-0.0	-1.2
Number of live births	0.3	0.5	1.8	-0.2	-0.2	-1.3	0.7	-0.6	0.0	1.0	0.3	0.2	0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	2.8	-0.0	1.3	-0.3	-0.1	0.7	-0.3	-0.5	0.5	1.7	0.1
Pulse rate	0.5	0.8	1.9	1.3	0.8	0.4	0.3	-0.8	-1.4	-1.4	0.7	-0.5	-0.9
Happiness	1.3	1.6	4.6	2.1	0.1	1.9	-0.2	1.7	-0.2	-1.1	0.3	-0.6	1.7
Noisy workplace	0.8	1.0	4.1	0.6	0.5	1.1	-0.8	2.0	-0.7	-0.8	0.2	1.4	0.7
Qualifications: A levels/AS levels or equivalent	1.4	3.0	10.6	-1.5	1.1	0.9	1.9	-1.9	3.3	2.1	1.2	1.6	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.5	0.3	0.1	0.5	-1.5	0.7	-1.0	-1.6	-0.8	-0.6	-0.1
Mouth/teeth dental problems: Dentures	0.8	1.4	5.7	1.9	1.3	2.4	0.4	1.0	0.4	0.1	0.6	0.0	1.1
Asthma	0.2	0.4	1.9	0.2	-1.4	1.0	0.3	-0.8	0.1	-0.3	-0.2	-0.0	0.1
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.5	6.4	2.2	1.6	1.9	1.2	1.1	1.3	-0.1	1.6	0.3	2.5
Medication: Cholesterol lowering	0.3	0.5	2.3	-0.1	0.5	-0.3	0.7	-1.5	0.2	-0.1	0.5	-0.5	-1.2
Depression (self-reported)	0.5	0.7	2.9	0.4	-0.6	-1.1	-0.3	0.2	-0.8	-0.1	-0.8	-1.7	-0.7
Medication: Lansoprazole	0.2	0.2	0.6	-0.6	-0.6	-0.7	0.3	-0.8	-0.4	-0.1	-0.1	-0.6	-0.1
Prospective memory result	3.5	4.3	14.3	-0.7	-1.5	-3.1	-1.7	0.0	-3.8	-2.1	-1.9	-1.2	-1.9
Lung cancer (father)	0.4	0.5	2.0	-0.8	-0.2	-1.4	-0.0	-1.2	-0.3	0.4	-0.4	-0.6	-0.5
Illnesses of mother	0.7	0.9	2.9	1.7	1.5	0.5	0.6	1.1	0.3	-0.2	0.8	-0.5	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.4	5.1	0.2	1.6	-0.2	-1.0	1.1	-1.5	-2.3	-0.2	1.1	-0.9
Pulse wave Arterial Stiffness index	1.3	1.5	4.2	2.0	-0.2	0.6	-0.8	1.2	-1.0	-1.9	0.3	-1.8	0.1
Impedance of arm (left)	0.3	1.5	4.0	-1.1	-0.7	-1.8	1.0	-1.6	1.1	2.0	0.5	0.5	0.2
Arm fat mass (right)	0.3	1.1	5.6	1.1	0.7	2.4	-0.4	0.3	-0.7	-1.6	-0.5	-0.5	-0.1
Trunk predicted mass	1.5	8.7	23.0	0.3	0.9	2.3	-3.8	4.2	-4.2	-4.8	-2.1	1.7	-1.0
Standing height	1.5	15.1	34.9	-0.9	0.4	0.9	-5.2	5.5	-5.9	-5.4	-3.1	3.9	-1.6
Length of working week for main job	1.6	1.7	6.9	2.6	1.6	1.7	0.7	0.4	0.3	-1.1	0.9	-1.6	0.2
Exposure to tobacco smoke at home	0.7	0.7	2.0	1.1	-0.5	0.0	1.0	-1.0	-0.6	-1.0	1.4	-0.8	-0.1
Breastfed as a baby	0.8	1.0	3.9	2.0	0.1	0.5	-0.3	1.5	-1.0	-1.2	-0.1	-0.5	0.4
Tense / ‘highly strung’	0.8	1.3	3.8	1.8	0.7	2.0	0.5	0.6	0.4	-0.3	1.1	0.4	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	3.5	0.2	0.0	0.5	0.8	-0.4	1.6	1.6	0.7	0.3	1.9
Hair/balding pattern: Pattern 4	0.7	1.6	6.0	2.4	1.3	1.8	0.6	1.4	0.1	-0.6	1.0	-0.3	1.4
Birth weight of first child	0.4	0.7	3.2	-1.2	-1.8	-0.7	0.3	-0.8	0.4	0.8	-0.6	0.1	-0.8
Peak expiratory flow (PEF)	0.2	0.5	2.1	-0.4	0.1	-1.4	-0.6	1.0	-0.6	-0.3	-0.4	0.0	-0.8
Pulse wave reflection index	0.3	0.4	1.1	0.7	1.1	0.8	-0.1	0.9	0.5	-0.1	0.1	-0.5	0.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.9	0.7	-0.5	-0.2	-1.0	0.7	-1.4	-1.4	-0.7	-0.1	0.1
Loud music exposure frequency	4.0	4.4	11.7	-1.9	-2.9	-1.9	-2.9	0.6	-2.4	-0.9	-3.4	-1.1	-0.5
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	6.0	-2.0	0.1	-0.1	1.0	-1.4	2.3	2.4	0.4	2.3	0.6
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.3	0.1	-0.9	-0.1	-0.8	1.0	-0.9	-1.2	-0.4	-0.9	-0.2
Blood clot in the leg (DVT)	1.4	1.8	5.5	1.8	1.8	1.1	0.8	-0.2	0.3	0.3	1.6	0.9	2.4
Medication: Paracetamol	0.3	0.4	1.2	-0.0	0.3	0.1	-0.9	1.1	-0.5	-0.8	-0.7	-0.7	-0.6
Headache pain in last month	0.9	1.5	4.5	1.1	0.6	1.6	-0.6	2.1	-0.9	-1.1	0.3	0.7	1.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.7	-0.2	-0.5	-0.5	-0.1	0.0	0.3	0.8	-0.6	-0.4	1.3
Glaucoma (self-reported)	0.2	0.2	0.7	-0.1	-0.8	-0.3	-0.2	0.3	-0.6	-0.4	0.2	0.6	-0.5
Gout (self-reported)	0.5	0.7	1.5	1.2	-0.9	0.8	0.6	0.0	1.2	0.0	1.1	-0.8	0.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.5	-0.6	-0.5	0.1	-1.2	0.2	-0.7	0.1	-1.2	1.2	0.6
Medication: Amlodipine	1.0	1.3	3.6	0.7	1.5	1.4	0.3	1.4	0.2	-0.9	1.9	1.5	0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.6	2.1	0.4	-1.4	-0.0	-0.7	0.2	-0.4	-0.3	-0.9	-1.2	-0.7
Birth weight	0.8	1.8	7.1	-1.1	-2.7	-1.6	-0.4	-1.7	-0.4	0.8	-1.4	0.5	-1.0
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.1	-1.2	-1.5	-0.9	-0.4	-0.9	-0.1	0.6	-1.1	-0.2	-0.7
High blood pressure (siblings)	0.4	0.6	2.3	-0.5	-0.2	1.5	0.8	-0.0	0.8	0.4	0.7	1.0	0.1
Forced vital capacity (FVC), Best measure	0.7	2.5	5.5	-0.9	1.4	-0.2	-1.8	1.1	-2.0	-2.2	-1.3	2.4	-1.2
Body fat percentage	0.2	0.7	3.4	1.0	0.6	1.8	1.0	-0.6	0.7	-0.1	0.5	-0.4	-0.0
Leg fat percentage (right)	0.2	0.8	2.6	1.1	0.8	1.6	1.1	-0.9	0.8	0.0	0.2	-1.1	-0.0
Arm fat-free mass (right)	1.3	6.7	17.9	0.3	0.3	2.0	-3.2	3.9	-3.6	-4.2	-2.0	1.3	-1.1
Exposure to tobacco smoke outside home	0.4	0.5	2.1	-0.7	-1.1	-1.5	-0.1	-0.5	-0.8	0.1	-0.4	0.2	-0.0
Comparative body size at age 10	0.7	1.8	6.1	0.2	0.7	-0.3	2.0	-2.5	1.4	1.9	0.5	-0.9	0.9
Number of full brothers	1.0	1.3	4.1	0.5	0.3	0.4	2.0	-1.8	1.4	0.7	1.5	-0.7	-0.4
Worry too long after embarrassment	0.8	1.4	3.8	1.5	0.6	1.6	0.1	1.9	0.5	-0.6	1.1	0.3	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.7	0.1	0.3	-0.2	0.9	-0.6	1.0	1.3	0.2	-0.1	0.4
Wheeze or whistling in the chest in last year	0.6	1.1	3.8	-0.3	-0.2	0.3	-1.1	0.1	-1.5	-1.9	-1.3	-0.8	-0.9
Number of children fathered	1.7	1.9	5.2	0.4	0.3	0.6	1.5	-1.2	2.3	2.2	1.4	0.8	1.5
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.5	7.3	-0.6	1.3	1.7	-2.2	2.7	-1.5	-1.7	-1.1	1.2	-0.2
Age at first live birth	0.4	0.7	1.5	-0.3	-0.6	0.6	-1.0	0.5	-1.0	-1.2	-1.2	0.1	-0.8
Pulse wave peak to peak time	1.1	1.3	5.1	-2.3	-0.1	-0.7	0.2	-0.9	0.5	1.5	-0.8	1.8	-0.3
Health satisfaction	0.1	0.1	0.3	0.5	-0.3	0.4	0.0	-0.1	-0.4	-0.2	-0.5	0.2	0.5
Shortness of breath walking on level ground	0.8	1.0	3.1	1.8	-0.7	1.0	0.5	0.6	-0.6	-1.5	1.0	-0.7	0.8
Qualifications: College or University degree	0.3	1.0	3.2	-0.1	0.1	-0.5	1.2	-0.7	1.7	1.8	0.4	1.0	-0.7
Eye problems/disorders: None of the above	2.3	2.7	6.8	1.7	0.6	1.2	2.1	-0.5	2.6	1.9	1.7	-0.1	2.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.3	0.3	0.9	0.9	-0.1	1.1	-0.7	-0.9	0.7	0.0	0.2
Emphysema/chronic bronchitis	0.3	0.3	1.0	0.1	0.4	-0.3	-0.3	0.7	-0.1	1.0	-0.7	0.9	0.2
Medication for pain relief, constipation, heartburn	1.0	1.8	3.9	-1.3	-1.4	-1.6	-1.0	-1.2	-1.4	-0.5	-2.0	-1.0	-1.3
Neck or shoulder pain in last month	1.0	1.5	5.6	-0.2	0.3	0.0	-0.8	1.1	-2.1	-2.4	-0.1	-0.2	-1.6
Medication: Blood pressure	0.7	1.3	4.4	0.7	0.4	0.9	-1.0	1.7	-1.4	-2.1	0.5	0.5	-1.1
Angina (self-reported)	0.4	0.5	1.5	-0.9	1.2	-0.1	0.7	-1.2	0.3	0.5	0.4	0.2	-0.1
Migraine (self-reported)	1.5	1.8	9.3	-1.2	-0.4	-1.9	0.5	-3.0	0.5	1.5	-0.9	-0.3	-0.5
Medication: Ibuprofen	2.6	3.2	8.7	2.4	1.6	2.1	1.0	1.9	1.4	-0.0	1.8	0.5	3.0
Medication: Allopurinol	1.5	2.0	5.4	1.5	0.7	0.8	1.9	-1.4	2.3	1.3	1.6	-0.4	0.7
Medication: Omeprazole	0.6	0.7	2.8	0.3	0.1	-0.9	-0.5	0.5	-0.9	-1.4	0.2	-1.7	-0.5
Medication: Seretide 50 evohaler	0.4	0.5	1.8	-0.8	0.3	0.6	0.4	-0.3	0.8	0.8	0.3	1.3	-0.1
Mean time to correctly identify matches	1.7	3.3	8.2	2.9	1.2	2.9	1.2	2.0	0.1	-1.3	2.4	1.4	0.4
Heart disease (mother)	0.5	0.6	1.0	0.7	0.3	0.9	1.0	-0.7	1.0	1.0	1.0	0.6	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.2	1.0	1.3	1.5	-0.9	0.3	-0.4	-1.3	-0.8	-1.8	0.8
Whole body fat mass	0.3	1.2	5.3	1.1	0.8	2.3	-0.5	1.0	-0.8	-1.8	-0.3	0.1	-0.4
Leg fat mass (right)	0.3	1.1	4.6	1.3	0.7	2.1	-0.3	0.7	-0.7	-1.7	-0.3	-0.6	-0.3
Arm predicted mass (right)	1.4	7.1	19.2	0.4	0.6	2.1	-3.2	3.9	-3.7	-4.4	-2.0	1.2	-1.2
Pulse rate, automated reading	0.3	1.1	4.5	2.1	1.0	1.2	0.4	-0.2	-1.1	-1.3	0.7	-0.5	-0.4
Alcohol intake frequency.	0.9	2.0	13.2	0.8	-1.3	-0.6	0.4	-1.5	-0.7	-0.4	-1.1	-3.6	0.3
Comparative height size at age 10	1.4	7.9	22.4	-1.7	0.5	0.1	-4.1	2.6	-4.7	-3.4	-3.3	2.3	-1.5
Number of full sisters	0.4	0.5	2.7	0.6	-1.6	-0.4	-0.2	0.2	-0.6	-0.2	-0.3	-1.0	-0.1
Suffer from ‘nerves’	0.1	0.2	1.1	-0.2	0.5	0.2	-0.4	0.6	-0.2	-0.3	0.2	1.1	0.1
Overall health rating	0.3	0.6	1.9	0.9	0.5	0.9	0.2	0.3	-1.0	-1.4	0.8	-0.5	0.5
Chest pain or discomfort	0.5	0.7	1.8	-0.1	0.5	0.2	1.4	-0.9	1.3	0.8	1.3	-0.1	0.4
Had major operations	0.5	0.5	1.4	0.3	-0.7	1.0	0.2	1.2	0.4	-0.5	0.5	0.7	-1.0
Age at last live birth	0.5	0.7	3.0	1.0	1.7	0.8	0.5	0.3	0.5	0.2	0.3	0.9	0.9
Family relationship satisfaction	1.0	1.3	4.7	-0.7	0.3	1.1	-1.6	2.2	-0.4	0.1	-1.6	1.0	0.3
Leg pain on walking	1.7	2.2	5.4	2.2	-0.0	1.1	-1.0	2.1	-1.7	-2.3	0.1	-0.9	1.0
Qualifications: NVQ or HND or HNC or equivalent	3.0	3.7	9.4	-0.7	-3.1	-0.7	-2.5	0.4	-2.3	-2.0	-2.4	-2.1	-0.9
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.1	0.6	-0.2	0.4	-0.8	1.7	-1.3	-1.8	0.1	-0.2	-0.4
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	7.2	1.6	1.6	0.7	2.7	-1.3	2.2	1.5	2.0	0.0	0.8
Medication: Aspirin	1.2	1.6	4.4	0.1	1.9	0.8	0.9	-0.3	1.5	1.4	1.3	2.1	0.4
Supplements: Vitamin C	0.4	0.5	1.2	0.0	-1.0	-0.4	-1.1	0.5	-0.8	-0.8	-0.9	-0.2	0.5
Knee pain experienced in last month	0.2	0.3	0.7	0.8	0.8	0.6	-0.2	0.1	-0.4	-0.6	-0.4	-0.5	0.7
Hypertension (Self-reported)	0.7	1.9	6.1	1.2	1.4	1.7	-0.3	1.0	-1.7	-2.5	1.0	0.5	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	3.8	0.4	0.4	-0.1	-0.1	0.9	0.3	0.5	0.6	-0.6	2.0
Illnesses of father: Heart disease	0.4	0.5	1.2	0.5	-0.9	-0.3	0.9	-0.9	-0.2	-0.3	1.0	-1.1	0.1
Illnesses of siblings: Diabetes	1.1	1.3	3.2	1.5	0.7	1.1	1.8	-0.1	1.5	0.1	1.6	0.4	-0.9
Smoking status: Previous	1.0	1.6	4.5	0.4	1.1	2.1	-1.3	1.6	-1.0	-2.1	0.1	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.2	11.6	-1.9	-0.1	-0.6	-3.1	1.2	-3.4	-3.1	-3.0	-0.0	-2.5
Whole body fat-free mass	1.4	8.1	21.9	0.6	0.8	2.5	-3.5	4.1	-3.9	-4.7	-2.0	1.6	-0.9
Leg fat-free mass (right)	1.1	5.8	16.0	0.8	0.7	2.4	-2.8	3.6	-3.1	-4.0	-1.4	1.5	-0.7
Arm fat percentage (left)	0.3	1.0	3.2	1.1	0.7	1.8	1.2	-1.3	1.0	0.1	0.5	-0.9	0.1
Average weekly red wine intake	0.6	0.9	2.5	-1.4	0.4	-0.8	-0.8	-0.4	-0.1	0.4	-1.6	0.7	-1.3
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.3	-0.5	-1.8	-0.2	-1.4	-0.2	-1.2	-0.7	-1.6	-0.8	-0.2
Mood swings	1.1	1.9	4.2	2.0	1.7	1.8	-0.4	2.1	-0.5	-0.7	0.5	0.8	1.8
Loneliness, isolation	0.5	0.7	1.9	1.1	-0.4	1.3	0.1	1.1	0.4	0.2	0.6	0.2	1.4
Long-standing illness, disability or infirmity	0.8	1.3	5.5	-0.4	-1.4	-0.5	-0.4	-0.3	-1.3	-1.5	-0.7	-0.6	-2.3
Ever had bowel cancer screening	1.8	2.1	5.8	2.4	0.2	1.4	1.2	1.5	0.5	0.3	2.0	0.3	2.3
Diabetes diagnosed by doctor	0.6	1.0	2.3	0.2	0.1	-0.1	-0.8	-0.7	-1.4	-1.5	-1.2	-1.5	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.9	0.5	0.8	0.8	-0.8	1.5	-1.1	-1.7	-0.1	0.4	-0.3
Friendships satisfaction	1.1	1.4	5.3	1.3	-0.6	1.1	-0.7	1.5	0.3	1.0	-0.6	1.2	2.3
Qualifications: nursing, teaching	0.2	0.3	1.1	-0.2	0.5	0.1	0.6	-0.5	1.1	0.7	-0.2	-0.2	0.2
Commuting to job workplace: Walk	1.3	1.4	5.1	-0.6	0.7	-0.4	0.6	-1.0	1.2	2.2	-0.3	1.2	1.8
Eye problems/disorders: Cataract	0.9	1.0	2.7	-1.4	-0.6	-1.6	-0.7	-0.9	-1.2	-0.1	-0.8	0.5	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.5	0.6	-0.6	0.4	-1.0	1.1	-1.1	-1.2	-0.5	-0.3	-0.8
Medication for cholesterol	0.5	0.8	1.8	-0.3	-1.3	-0.1	-1.3	1.3	-0.9	-0.3	-1.3	-0.6	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.2	0.4	-0.7	0.4	0.7	0.3	0.7	0.9	0.5	0.3	1.5
Back pain experienced in last month	0.5	0.7	3.0	0.1	-0.4	-0.2	-0.9	1.7	-1.0	-1.2	-0.3	0.3	0.2
Mineral and other dietary supplements	0.3	0.5	1.6	-0.2	0.6	-0.7	0.0	-0.7	-0.9	-0.7	-0.5	-1.2	-0.4
Breast cancer (self-reported)	0.5	0.6	2.4	-0.5	-1.4	-0.3	-0.5	1.5	-0.4	0.5	-0.4	0.8	-0.1
Asthma (self-reported)	0.3	0.5	2.0	0.7	-1.1	1.4	0.4	-0.6	-0.0	-0.8	0.1	0.0	0.3
Osteoporosis (self-reported)	0.7	0.9	2.7	-1.2	-0.5	-1.0	0.6	0.3	1.1	1.6	0.5	1.1	0.5
Osteoarthritis (self-reported)	2.1	2.7	7.2	-0.4	-1.6	-1.1	-0.7	-1.3	-1.9	-1.5	-1.5	-2.2	-2.7
Medication: Aspirin	1.3	1.6	3.9	-0.2	1.7	0.4	1.1	-0.5	1.8	1.7	1.3	2.0	0.4
Medication: Gliclazide	0.2	0.3	0.9	-0.3	0.2	-0.3	0.3	-0.7	0.3	-0.2	-0.2	-0.9	-1.0
Illnesses of father: None of the above (group 1)	0.3	0.4	1.6	-0.5	-0.0	0.0	-0.7	-0.5	0.4	0.6	-1.3	-0.4	0.6
Smoking status: Current	0.5	0.8	2.6	1.3	1.6	0.5	0.9	-0.0	0.9	1.2	-0.0	0.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	2.5	0.8	0.5	-0.3	1.0	0.1	0.8	-0.3	1.6	0.4	-0.2
Whole body water mass	1.3	7.7	20.5	0.7	0.9	2.6	-3.4	4.0	-3.7	-4.5	-1.9	1.7	-0.8
Leg predicted mass (right)	1.0	5.6	15.3	0.8	0.7	2.5	-2.8	3.5	-3.0	-3.9	-1.3	1.6	-0.6
Arm fat mass (left)	0.2	1.0	4.1	0.7	0.3	2.0	-0.6	0.3	-0.8	-1.6	-0.7	-0.6	-0.5
Number of self-reported non-cancer illnesses	0.4	0.7	1.4	0.9	0.3	1.2	0.6	0.7	-0.5	-1.1	1.2	0.8	-0.4
Average weekly champagne plus white wine intake	0.5	0.7	2.6	0.2	-0.7	0.5	0.5	-0.9	1.2	1.6	0.1	0.8	1.0
Miserableness	1.0	1.8	5.9	2.4	0.9	1.3	0.1	1.1	0.6	0.2	0.8	-1.1	2.4
Guilty feelings	0.5	0.8	3.1	0.7	0.2	1.2	-0.8	1.4	-0.4	-0.5	-0.1	0.3	1.8
Wears glasses or contact lenses	0.6	0.7	1.8	-0.2	-0.3	0.1	-0.9	0.5	-1.4	-1.1	-1.0	-0.7	-1.2
Ever taken oral contraceptive pill	0.6	0.7	2.6	-0.0	1.6	0.9	0.8	-0.7	0.9	0.1	0.8	0.7	-0.3
Hearing aid user	0.3	0.3	1.0	-0.5	0.4	0.3	-0.2	0.1	0.8	0.4	-0.6	1.0	-0.5
Mother’s age at death	0.7	0.9	2.9	-1.4	-1.7	-1.0	0.3	-1.2	0.7	0.7	-0.2	0.2	-0.2
Financial situation satisfaction	2.1	2.6	7.6	1.2	-0.7	0.4	-2.2	0.7	-2.8	-2.5	-1.7	-1.3	0.7
Tinnitus: Yes, now most or all of the time	1.3	1.6	7.7	0.1	0.0	1.1	-1.3	2.8	-0.8	-1.4	0.5	1.1	0.8
Commuting to job workplace: Public transport	0.5	0.6	2.3	-1.5	-0.5	-1.3	-0.6	0.0	0.2	0.5	-0.7	-0.4	-0.6
Eye problems/disorders: Glaucoma	1.6	1.9	3.6	-1.9	-1.1	-1.6	-1.3	-0.6	-1.9	-1.1	-1.1	0.2	-1.9
Medication: Blood pressure	0.4	0.7	2.1	0.2	1.2	0.5	0.5	-0.7	-0.4	-1.2	1.0	-0.3	-1.4
Pain type(s) experienced in last month: Hip pain	1.6	2.0	5.6	-1.5	-2.4	-1.2	-1.5	0.7	-1.2	-0.8	-1.5	-0.6	-1.9
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.4	0.1	-1.2	0.3	-0.3	0.3	0.6	0.6	-0.3	0.3	0.2
High cholesterol (Self-reported)	0.4	0.7	1.7	1.3	0.7	1.0	0.5	0.9	0.6	-0.6	1.3	0.2	0.3
Medication: Bendroflumethiazide	0.6	0.9	2.6	0.0	1.0	0.8	-0.1	-1.4	-1.2	-1.6	-0.5	-0.0	-0.9
Medication: Paracetamol	0.4	0.6	1.7	0.7	0.5	0.5	-0.7	1.3	-0.6	-1.2	0.0	-0.6	-0.7
Medication: Lisinopril	1.3	1.7	5.3	0.1	-0.4	1.0	-1.6	1.6	-1.7	-2.3	-0.4	-0.7	-1.2
Medication: Atorvastatin	0.4	0.5	1.1	0.9	0.9	0.8	1.1	-0.5	0.2	-0.8	1.1	-0.2	0.1
Illnesses of father: High blood pressure	0.2	0.2	0.8	-0.7	0.1	-0.9	-0.6	-0.3	-0.3	0.1	-0.6	0.0	-0.4
Alcohol drinker status: Never	3.0	3.5	10.0	-2.9	-1.6	-2.0	-1.8	-1.6	-1.8	-0.0	-3.2	-1.0	-0.4
Ever smoked	1.4	2.4	8.9	2.1	1.8	3.0	0.1	1.9	0.9	-0.6	1.1	0.3	1.1
Basal metabolic rate	1.3	7.3	20.3	0.7	0.9	2.7	-3.3	3.8	-3.6	-4.5	-1.9	1.4	-0.8
Leg fat percentage (left)	0.2	0.7	2.6	1.0	0.6	1.6	1.1	-0.8	0.8	-0.0	0.2	-0.8	-0.3
Arm fat-free mass (left)	1.5	7.6	19.3	0.6	0.5	2.5	-3.5	4.0	-3.8	-4.4	-2.2	1.4	-0.8
Number of operations (self-reported)	0.3	0.5	2.5	-0.8	-1.6	0.0	-0.4	0.7	0.4	0.4	-0.7	0.4	-0.3
Average weekly beer plus cider intake	0.7	1.0	2.2	1.5	1.2	1.1	0.6	0.5	0.4	-0.4	1.4	0.1	1.4
Irritability	1.4	2.4	8.6	2.9	1.9	2.5	0.7	0.8	0.3	-0.4	1.4	0.3	1.6
Risk taking	0.8	1.1	3.1	1.0	1.2	1.2	0.5	0.7	0.5	0.0	0.7	1.8	1.7
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.8	-0.1	0.5	-0.1	0.4	-0.1	0.0	-0.1	0.9	0.1	-0.3
Fractured/broken bones in last 5 years	0.2	0.3	1.0	0.4	0.7	0.2	-0.4	0.6	-0.4	0.2	-0.3	0.8	1.0
Age started oral contraceptive pill	1.0	1.3	3.8	-1.4	-1.0	-0.3	-1.9	0.7	-1.2	0.1	-1.7	1.0	-0.2
Diastolic blood pressure, automated reading	0.5	1.5	4.0	1.4	1.3	2.0	1.4	-0.1	1.2	-0.4	1.8	-0.2	-0.2
Ever depressed for a whole week	0.5	0.6	3.0	0.3	-0.6	-0.3	0.1	0.5	-0.8	-1.3	0.4	-0.4	-1.7
Unable to work because of sickness or disability	1.2	1.6	3.5	1.5	1.1	1.2	1.9	-0.1	1.6	1.4	1.3	-0.0	1.2
Commuting to job workplace: Cycle	0.3	0.4	0.7	0.7	-0.6	-0.6	0.0	0.6	-0.7	-0.8	0.3	-0.8	-0.5
Myopia	0.1	0.2	0.8	-0.5	0.1	-0.6	0.7	-0.2	0.1	0.2	0.9	-0.2	-0.2
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.0	-0.8	-1.5	-1.2	-0.4	-0.1	1.2	1.7	-1.2	-0.6	1.3
Cholesterol lowering medication	0.2	0.4	0.9	0.5	0.3	0.3	0.1	0.9	0.4	0.2	0.6	0.9	1.0
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	5.8	0.5	-0.3	-1.1	0.1	-0.5	-0.8	-1.2	0.5	-2.4	-0.5
Pain experienced in last month	0.6	1.1	3.3	-1.0	-0.7	-1.5	0.6	-1.8	0.4	1.3	-0.5	-0.1	-1.1
Supplements: Calcium	0.8	0.8	2.5	0.3	-0.3	-0.6	-0.9	0.6	-1.4	-1.6	-0.3	-1.1	-1.0
Basal cell carcinoma (self-reported)	0.5	0.5	1.7	1.3	-0.1	0.7	1.0	-0.0	0.7	0.1	0.9	-0.8	0.5
Heart attack/myocardial infarction (self-reported)	0.8	1.0	4.0	-0.1	0.9	-0.7	1.2	-2.0	0.3	0.3	1.0	-0.3	-1.3
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	5.4	1.5	1.6	1.0	1.1	-0.6	0.8	0.8	1.7	1.2	2.3
Heart disease (siblings)	1.0	1.2	4.0	0.2	0.3	-0.2	1.8	-2.0	1.1	1.5	0.9	0.7	-0.3
Alcohol drinker status: Previous	0.7	0.8	2.3	1.2	0.5	0.7	-0.5	0.4	-1.1	-1.5	-0.8	-0.8	-0.8
Pack years of smoking	1.1	1.6	6.4	-0.1	2.5	1.5	-0.2	0.5	-0.1	-0.7	0.5	2.2	-1.0
Impedance of whole body	0.2	1.0	2.6	-0.9	-0.5	-1.6	0.9	-1.1	0.9	1.6	0.6	0.7	0.2
Leg fat mass (left)	0.3	1.2	4.5	1.3	0.6	2.1	-0.2	0.5	-0.8	-1.8	-0.2	-0.6	-0.7
Arm predicted mass (left)	1.6	8.0	20.7	0.8	0.9	3.0	-3.4	4.2	-3.7	-4.5	-2.0	1.4	-0.7