Best TWAS P=1.08e-11 · Best GWAS P=5.99e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC100630918 | 0.08 | 0.05 | lasso | 4 | 0.05 | 6.9e-07 | -6.8 | 6.4 | 1.9e-10 | -0.79 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | GGCX | 0.13 | 0.03 | lasso | 7 | 0.03 | 1.1e-02 | -4.6 | -5.3 | 1.1e-07 | 0.77 | 0.37 | 0.14 | FALSE |
| 3 | GTEx | Brain Caudate basal ganglia | RP11-301O19.1 | 0.20 | 0.26 | enet | 32 | 0.14 | 7.2e-05 | -3.8 | -5.2 | 2.5e-07 | -0.07 | 0.14 | 0.54 | TRUE |
| 4 | GTEx | Breast Mammary Tissue (Female) | RP11-301O19.1 | 0.22 | 0.03 | enet | 24 | 0.07 | 4.7e-03 | 3.7 | -5.1 | 3.1e-07 | -0.15 | 0.03 | 0.55 | FALSE |
| 5 | GTEx | Esophagus Mucosa | VAMP8 | 0.41 | 0.31 | lasso | 6 | 0.36 | 6.6e-25 | -4.5 | 5.5 | 4.6e-08 | -0.87 | 0.54 | 0.46 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | VAMP8 | 0.14 | 0.13 | enet | 19 | 0.13 | 5.4e-11 | -6.9 | 6.3 | 3.4e-10 | -0.94 | 0.01 | 0.99 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | VAMP8 | 0.06 | 0.05 | lasso | 2 | 0.04 | 1.8e-06 | -6.0 | 6.4 | 1.4e-10 | -0.97 | 0.01 | 0.99 | FALSE |
| 8 | YFS | Blood | MAT2A | 0.12 | 0.06 | bslmm | 472 | 0.09 | 8.7e-27 | -4.9 | 5.2 | 1.8e-07 | -0.56 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | VAMP8 | 0.06 | 0.06 | enet | 6 | 0.07 | 1.8e-06 | -6.8 | 6.0 | 2.5e-09 | -0.88 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | VAMP8 | 0.05 | 0.05 | blup | 43 | 0.06 | 6.9e-13 | -6.8 | 6.2 | 6.4e-10 | -0.96 | 0.01 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | VAMP8 | 0.05 | 0.04 | lasso | 4 | 0.03 | 1.3e-04 | -6.0 | 5.3 | 1.3e-07 | -0.90 | 0.01 | 0.98 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | VAMP5 | 0.06 | 0.04 | lasso | 2 | 0.04 | 3.2e-05 | -5.3 | 5.6 | 1.7e-08 | -0.69 | 0.05 | 0.90 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | RNF181 | 0.03 | 0.00 | blup | 39 | 0.01 | 1.5e-02 | -4.1 | 6.2 | 6.2e-10 | -0.67 | 0.01 | 0.49 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | VAMP8 | 0.07 | 0.07 | blup | 43 | 0.06 | 4.8e-08 | -6.9 | 5.3 | 1.4e-07 | -0.90 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | VAMP8 | 0.05 | 0.04 | lasso | 3 | 0.03 | 2.0e-04 | -6.9 | 6.8 | 1.1e-11 | -1.00 | 0.01 | 0.99 | TRUE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | VAMP8 | 0.07 | 0.06 | blup | 39 | 0.06 | 3.0e-07 | -6.0 | 5.8 | 6.6e-09 | -0.92 | 0.01 | 0.99 | FALSE |