Hub : Genes

MAT2A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.4140	0.0880	6.3e-06	0.078	NA	0.146	NA	0.112	2.6e-03	NA	4.5e-05	NA	3.5e-04
2	YFS	Blood	0.1165	0.0231	0.0e+00	0.060	0.079	0.076	0.086	0.064	7.7e-19	1.5e-24	1.5e-23	8.7e-27	4.7e-20
3	TCGA	Brain Lower Grade Glioma	0.0452	0.0271	2.6e-03	0.027	0.026	0.024	NA	0.020	3.8e-04	5.3e-04	8.2e-04	NA	2.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.6	4.1	10.8	3.3	1.1	-0.3
Bipolar Disorder or Schizophrenia	1.8	4.3	12.5	3.5	-0.1	-0.6
Depressed Affect (Nagel 2018)	1.1	2.3	4.0	-1.4	2.0	1.0
Depression (Nagel 2018)	0.7	1.1	1.8	-1.4	0.5	-1.0
Intelligence (Savage-Jansen 2018)	0.5	1.5	3.6	1.9	0.1	1.0
Neuroticism (Nagel 2018)	1.2	2.7	4.3	-1.5	2.1	1.2
Schizophrenia (2018)	0.8	1.6	3.5	1.9	-1.0	-0.6
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	-0.1	-0.8	-0.4
Worry (Nagel 2018)	0.5	1.2	2.9	-1.7	0.7	0.3
Alzheimer’s Disease (in mother)	2.4	2.8	3.0	1.7	-1.7	1.6
Alzheimer’s Disease (in father)	3.9	4.3	7.6	1.2	-1.9	-2.8
Alzheimer’s Disease (including proxy)	1.8	2.6	4.2	1.9	-2.1	-0.2
Crohns Disease (2017)	0.1	0.1	0.2	-0.2	0.3	-0.5
Irritable Bowel Disease (IBD)	0.2	0.4	0.9	-0.9	0.4	0.1
Ulcerative Colitis (UC)	0.6	1.2	3.6	-1.9	0.1	-0.1
Major Depression (MDD)	0.8	1.0	2.6	0.2	0.7	1.6
Reaction Time	0.3	0.6	1.5	-0.1	1.2	-0.6
Verbal and Numeric Reasoning (VNR)	0.7	1.7	4.2	2.0	-1.0	-0.0
Breast Cancer	1.3	3.0	8.8	-3.0	0.3	-0.5
Ovarian Cancer	0.6	0.7	1.7	-0.4	-1.3	-0.6
Prostate Cancer	3.2	4.4	12.9	3.6	0.6	0.0
Age at First Birth	0.9	1.3	1.9	1.4	1.1	0.8
Bipolar Disorder (2011)	3.1	3.0	8.3	2.9	-0.5	-0.7
Body Mass Index (BMI) (2010)	0.8	1.1	1.8	1.2	-1.4	-0.2
Coronary Artery Disease (CAD)	1.3	1.5	2.3	-1.5	-1.3	-0.8
Crohns Disease (2012)	0.8	1.3	3.0	-0.6	1.7	0.7
Mean Putamen Volume	1.4	1.6	2.6	1.6	-1.4	-0.2
Fasting Glucose	1.5	1.9	2.7	1.6	0.9	1.4
HbA1C	0.3	0.3	0.5	0.4	0.7	0.4
HDL Cholesterol	1.2	2.0	4.7	2.2	-0.7	-0.9
LDL Cholesterol	1.4	2.2	3.6	1.2	1.2	1.9
Lupus	0.6	0.9	2.5	0.1	1.6	0.3
Neuroticism (2016)	0.9	1.3	3.6	-1.9	-0.5	-0.2
Primary Biliary Cirrhosis	0.4	0.6	1.6	0.4	-0.0	1.3
Rheumatoid Arthritis	1.1	1.5	4.4	-0.4	0.0	-2.1
Schizophrenia (2014)	1.1	2.4	6.4	2.5	-0.3	-0.8
Triglycerides	0.4	0.7	1.8	0.3	0.5	1.4
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.3	0.6	-0.1	0.3
Ulcerative Colitis	0.2	0.3	0.6	-0.6	-0.3	0.8
Blood Eosinophil Count	2.4	18.4	27.2	1.6	5.2	5.0
Blood Platelet Count	2.4	27.8	38.2	6.2	-2.7	6.2
Blood Red Count	1.0	9.2	11.5	-2.3	3.3	3.4
Blood White Count	2.6	19.5	37.0	-6.1	4.5	0.9
Heel T-Score	0.3	2.6	4.8	1.6	2.2	0.7
BMI	0.3	1.8	2.5	1.6	-1.3	1.0
Height	0.1	1.7	4.5	-0.7	0.2	2.1
Waist Hip Ratio (WHR)	0.4	1.8	3.5	-1.2	1.9	0.7
Systolic Blood Pressure	0.4	1.8	4.4	0.2	-2.1	-0.9
Smoking Status	0.2	0.6	1.0	-1.0	0.2	-0.8
Allergy or Eczema	0.3	0.9	1.3	1.1	0.4	1.1
Cardiovascular Disease	0.3	0.9	1.3	-0.6	-1.0	1.1
Hypothyroidism (self reported)	1.6	3.6	6.8	-1.9	-0.6	-2.6
Respiratory disease	1.7	3.9	9.0	3.0	0.5	1.5
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.5	-1.2	0.4	-0.3
Lung FEV1/FVC ratio	1.2	6.3	14.1	-3.8	0.8	-2.0
Lung FVC	0.0	0.2	0.3	-0.4	-0.5	0.3
Neuroticism	1.5	3.7	5.1	-1.9	2.3	1.5
Chronotype (morning person)	1.0	2.3	4.6	-1.5	2.1	0.5
Hair Pigment	0.1	2.4	3.3	-1.8	-1.8	-0.8
Tanning	0.2	1.9	4.5	2.1	1.0	0.4
Hand grip strength (left)	0.3	0.7	1.5	-0.5	-1.2	0.7
Number of treatments/medications taken	0.6	1.1	1.8	-1.3	0.3	1.2
Average weekly spirits intake	0.8	1.0	2.2	-1.5	0.6	0.6
Sensitivity / hurt feelings	1.3	2.2	3.4	-1.9	1.8	0.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	-0.4	-0.5	-0.9
Hearing difficulty/problems: Yes	1.5	2.3	3.1	-1.6	1.8	1.1
Relative age of first facial hair	0.2	0.5	1.3	-1.1	-0.4	0.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	0.9	-0.6	-0.9	-0.9
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.2	1.2	0.9	1.5
Ever had hysterectomy (womb removed)	0.8	0.9	2.0	-0.3	-1.4	0.7
Systolic blood pressure, automated reading	0.5	1.4	4.1	-0.2	-2.0	0.0
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	5.0	0.4	-0.1	2.2
Angina	2.6	3.5	7.3	-1.1	-2.7	-1.4
Medication for hormone replacement therapy	0.7	0.8	1.9	0.5	0.4	1.4
Vitamin and mineral supplements	0.5	0.7	1.6	0.3	-0.6	1.2
Supplements: Zinc	0.1	0.1	0.1	0.2	0.3	0.2
Medication: Co-codamol	2.6	3.0	8.0	-2.8	0.7	0.7
Medication: Metformin	0.1	0.1	0.4	-0.6	-0.2	-0.1
Diabetes (father)	0.7	0.8	1.1	0.7	-1.0	0.9
Diabetes (mother)	0.4	0.5	0.8	-0.8	0.1	-0.9
Severe depression (siblings)	3.2	3.6	4.8	2.1	1.2	2.2
Pack years adult smoking proportion	0.6	0.9	1.5	-1.2	0.8	0.7
Impedance of leg (right)	0.7	3.3	7.3	-2.7	0.8	-1.4
Leg fat-free mass (left)	0.6	3.2	5.4	1.5	-1.4	2.3
Trunk fat percentage	0.6	2.2	6.6	0.2	-2.6	0.3
Hand grip strength (right)	0.2	0.5	0.6	-0.7	-0.8	0.7
Townsend deprivation index at recruitment	1.2	1.7	3.5	-1.9	-0.6	-1.1
Current tobacco smoking	2.0	3.3	8.6	-2.9	0.4	-1.1
Average weekly fortified wine intake	0.2	0.3	0.5	0.0	0.6	0.7
Maternal smoking around birth	0.6	0.8	2.3	-1.5	-0.4	0.2
Fed-up feelings	2.4	4.3	11.0	-3.3	1.1	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	4.1	-2.0	-0.7	-1.0
Relative age voice broke	0.7	1.1	2.0	-1.4	0.8	-0.8
Taking other prescription medications	1.3	2.0	2.7	-0.7	-1.7	-1.6
Age when periods started (menarche)	0.5	1.2	3.1	-1.8	0.6	0.2
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	6.2	0.2	-2.5	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.1	1.5	1.0	-0.3
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	0.3	0.7	0.0
Qualifications: CSEs or equivalent	0.8	1.1	2.3	-1.5	0.9	-0.2
Serious illness, injury or assault to yourself	1.6	1.9	3.2	1.5	-0.2	1.8
High blood pressure	0.3	0.9	1.6	-1.3	-0.1	1.0
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.2	0.0	0.3	0.5
Multivitamins +/- minerals	0.5	0.6	1.0	-0.5	0.8	-1.0
Stomach or abdominal pain in last month	0.7	0.8	2.2	-0.3	1.5	-0.4
Supplements: Glucosamine	0.5	0.7	1.0	0.9	0.5	-1.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.3	0.7	-0.1
Medication: Atenolol	0.1	0.1	0.2	-0.1	0.0	0.5
Medication: Levothyroxine sodium	0.6	1.0	1.9	0.2	-1.0	-1.4
Sitting height	0.9	6.3	10.4	2.9	0.2	3.2
Chronic bronchitis/emphysema (father)	0.5	0.6	1.0	-1.0	0.3	0.9
High blood pressure (mother)	0.8	1.1	2.6	0.1	-0.9	-1.6
Body mass index (BMI)	0.4	1.6	2.9	0.3	-1.7	1.4
Impedance of leg (left)	0.7	3.5	6.9	-2.6	0.9	-1.6
Leg predicted mass (left)	0.6	3.2	5.2	1.5	-1.4	2.3
Trunk fat mass	0.5	2.3	5.2	0.4	-2.3	1.2
Waist circumference	0.5	1.7	2.6	-0.0	-1.6	1.6
Number of incorrect matches in round	0.1	0.2	0.4	-0.6	-0.6	-0.2
Past tobacco smoking	0.3	0.5	1.6	0.0	0.1	1.3
Alcohol usually taken with meals	1.6	2.6	6.2	2.5	-0.1	1.2
Nervous feelings	0.3	0.5	1.1	-1.0	0.6	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.4	-0.5	-1.1	-1.6
Hearing difficulty/problems with background noise	0.4	0.6	1.3	-0.5	1.1	0.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.4	0.0	0.1	-0.7
Had menopause	0.8	1.0	1.0	1.0	-1.0	-1.0
Had other major operations	0.3	0.4	1.1	0.2	-1.1	0.3
Forced vital capacity (FVC)	0.2	0.9	2.1	-0.5	0.7	1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	5.6	2.4	1.4	1.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.7	0.7	0.4	1.7
Qualifications: None of the above	0.3	0.6	1.5	-1.2	-0.4	-0.0
Financial difficulties in last 2 years	3.7	4.9	11.2	-3.3	1.8	0.5
Mouth/teeth dental problems	0.4	0.6	1.0	0.1	1.0	-0.9
Heart attack	0.7	0.9	2.5	-0.5	-1.6	-0.0
Allergy	0.6	1.4	2.7	-1.6	-0.5	-1.2
Pain all over the body in last month	2.2	2.3	2.9	-1.2	-1.6	-1.7
Diabetes (self-reported)	0.2	0.3	0.5	-0.5	0.5	0.7
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	3.9	0.5	1.4	2.0
Medication: Ramipril	0.6	0.8	1.2	1.1	-0.5	0.9
Medication: Simvastatin	0.7	1.0	1.4	1.1	-1.2	0.8
Fluid intelligence score	0.0	0.1	0.2	0.5	0.1	0.2
Illnesses of siblings	0.3	0.4	1.1	1.1	0.1	-0.2
Neuroticism score	1.3	2.8	6.6	-2.6	1.3	0.2
Weight	0.5	2.2	4.4	0.3	-1.5	2.1
Impedance of arm (right)	0.7	3.3	9.4	-0.7	0.3	-3.1
Arm fat percentage (right)	0.5	1.8	5.2	0.5	-2.3	0.1
Trunk fat-free mass	0.6	3.7	10.2	0.8	-0.7	3.2
Hip circumference	0.6	2.5	4.7	0.7	-2.2	1.6
Time employed in main current job	1.4	1.6	3.5	0.4	-1.1	-1.9
Alcohol intake versus 10 years previously	0.8	1.2	3.1	-1.8	0.6	-0.3
Father’s age at death	0.4	0.5	0.8	-0.5	0.7	-0.9
Worrier / anxious feelings	1.4	2.7	4.1	-2.0	1.0	-1.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.1	-0.5	-0.2
Falls in the last year	1.5	2.0	5.2	-2.3	-0.2	-0.9
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	-0.3	0.1	0.1
Number of live births	0.7	1.0	2.4	-1.5	0.7	0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.5	-1.6	1.0	0.7
Pulse rate	1.7	2.9	4.3	-1.9	2.1	-1.0
Happiness	0.5	0.7	1.4	0.1	0.8	1.2
Noisy workplace	0.1	0.1	0.2	0.4	0.3	-0.1
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.2	1.5	0.8	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	0.8	-0.2	0.4
Mouth/teeth dental problems: Dentures	1.1	1.8	4.2	-0.4	-2.0	-1.0
Asthma	0.4	0.8	1.3	1.2	1.0	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.6	0.6	0.8	-0.7
Medication: Cholesterol lowering	0.3	0.5	0.7	0.1	-0.8	0.8
Depression (self-reported)	0.1	0.1	0.2	-0.1	-0.4	0.3
Medication: Lansoprazole	0.3	0.3	0.4	-0.6	-0.5	-0.5
Prospective memory result	0.6	0.8	1.3	1.1	-1.0	0.2
Lung cancer (father)	0.9	1.1	3.1	-0.3	1.8	-0.3
Illnesses of mother	0.3	0.3	0.8	0.5	0.2	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.7	-1.6	1.1	-0.5
Pulse wave Arterial Stiffness index	3.1	3.6	9.2	3.0	-1.0	0.7
Impedance of arm (left)	0.7	3.3	9.7	-0.3	0.4	-3.1
Arm fat mass (right)	0.4	1.5	2.8	0.3	-1.7	1.3
Trunk predicted mass	0.6	3.5	9.7	0.7	-0.6	3.1
Standing height	0.1	1.3	3.6	0.1	0.6	1.9
Length of working week for main job	0.2	0.2	0.3	-0.4	0.5	-0.5
Exposure to tobacco smoke at home	2.5	2.8	3.8	-1.9	-1.2	-1.8
Breastfed as a baby	0.2	0.2	0.4	0.7	-0.3	0.4
Tense / ‘highly strung’	0.5	0.8	2.0	-0.7	-0.2	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.3	-1.0	0.3	1.1
Hair/balding pattern: Pattern 4	0.2	0.4	0.8	0.7	0.3	-0.9
Birth weight of first child	0.6	1.2	1.7	1.3	0.4	1.3
Peak expiratory flow (PEF)	0.8	1.8	2.9	-0.2	1.5	1.7
Pulse wave reflection index	2.8	3.4	5.8	2.4	-0.8	1.9
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.6	-1.0	0.2	1.6
Loud music exposure frequency	0.9	1.0	1.6	-0.7	0.9	1.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.6	1.9	-0.4	0.2
Mouth/teeth dental problems: Bleeding gums	2.2	2.8	5.6	-1.2	1.1	2.4
Blood clot in the leg (DVT)	0.4	0.6	0.9	0.9	0.2	0.9
Medication: Paracetamol	0.4	0.6	1.3	-1.1	-0.6	0.5
Headache pain in last month	2.7	4.6	11.2	-0.9	3.4	1.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	-0.2	-0.0	-0.8
Glaucoma (self-reported)	0.0	0.0	0.0	-0.2	-0.1	-0.0
Gout (self-reported)	0.5	0.7	1.4	-1.2	0.1	-0.9
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	2.6	-1.5	-0.5	-1.6
Medication: Amlodipine	0.0	0.0	0.0	0.2	-0.0	-0.0
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	0.6	0.3	0.3
Birth weight	0.7	1.5	2.8	1.4	1.7	0.1
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.7	-0.0	1.3	0.9
High blood pressure (siblings)	0.3	0.4	0.9	-1.0	0.4	0.4
Forced vital capacity (FVC), Best measure	0.2	0.6	0.9	-0.6	0.9	0.7
Body fat percentage	0.5	2.0	5.9	-0.1	-2.4	0.3
Leg fat percentage (right)	0.5	2.0	4.8	-0.8	-2.2	0.7
Arm fat-free mass (right)	0.7	3.4	8.2	0.6	-1.2	2.9
Exposure to tobacco smoke outside home	4.1	5.4	11.9	-3.4	2.0	0.7
Comparative body size at age 10	0.6	1.6	3.3	1.8	-0.4	-1.2
Number of full brothers	0.6	0.8	1.7	0.8	-0.2	-1.3
Worry too long after embarrassment	1.4	2.3	3.5	-1.7	1.9	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	2.8	0.6	-1.5	1.7
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	-0.5	0.8	-0.1
Number of children fathered	1.1	1.3	3.3	0.3	1.8	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.7	0.4	1.3	0.8
Age at first live birth	0.8	1.4	2.5	1.6	1.1	-0.6
Pulse wave peak to peak time	2.9	3.4	8.5	-2.9	1.2	-0.3
Health satisfaction	0.8	1.0	1.3	1.1	-0.7	1.1
Shortness of breath walking on level ground	1.5	1.8	3.1	-0.6	-1.8	-1.4
Qualifications: College or University degree	1.0	3.3	5.1	1.5	2.3	1.6
Eye problems/disorders: None of the above	1.5	1.8	4.2	-0.9	-2.0	-0.5
Mouth/teeth dental problems: Loose teeth	0.5	0.7	1.4	-0.8	0.1	1.2
Emphysema/chronic bronchitis	1.6	1.8	2.5	1.6	-1.4	0.9
Medication for pain relief, constipation, heartburn	0.3	0.5	1.3	1.2	0.4	0.1
Neck or shoulder pain in last month	1.0	1.4	3.0	-0.8	1.7	-0.7
Medication: Blood pressure	0.1	0.1	0.2	0.4	0.2	0.3
Angina (self-reported)	1.9	2.5	5.6	-0.9	-2.4	-1.1
Migraine (self-reported)	1.0	1.3	3.0	-1.7	-0.1	-0.9
Medication: Ibuprofen	0.7	0.9	2.5	0.2	1.6	0.1
Medication: Allopurinol	1.1	1.4	3.8	-1.9	0.2	-0.6
Medication: Omeprazole	0.7	0.8	2.0	-0.4	-1.4	-0.6
Medication: Seretide 50 evohaler	1.8	2.1	6.1	2.5	-0.2	0.4
Mean time to correctly identify matches	0.1	0.3	0.6	0.1	0.3	-0.8
Heart disease (mother)	1.3	1.6	3.8	-1.0	-1.9	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.6	-1.3	0.3	0.9
Whole body fat mass	0.4	1.8	3.5	0.2	-1.9	1.3
Leg fat mass (right)	0.5	2.1	3.8	-0.1	-1.9	1.6
Arm predicted mass (right)	0.6	3.3	7.7	0.7	-1.3	2.8
Pulse rate, automated reading	0.8	2.7	6.1	-0.9	2.5	1.1
Alcohol intake frequency.	0.7	1.6	3.1	-1.2	1.8	0.7
Comparative height size at age 10	0.0	0.1	0.2	-0.4	0.1	0.2
Number of full sisters	0.2	0.3	0.5	-0.7	-0.3	-0.4
Suffer from ‘nerves’	0.3	0.4	0.8	-0.9	-0.2	0.7
Overall health rating	0.3	0.6	1.1	-1.1	0.7	0.5
Chest pain or discomfort	1.0	1.4	2.5	1.6	-1.1	0.6
Had major operations	2.7	3.2	5.0	2.2	-1.9	-1.0
Age at last live birth	0.8	1.1	3.2	0.3	1.8	0.3
Family relationship satisfaction	0.9	1.1	1.8	-0.8	1.4	0.9
Leg pain on walking	0.3	0.4	0.6	-0.8	-0.5	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.1	0.1	0.4	0.0	-0.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.3	0.1	1.1	1.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.8	0.5	-0.6	-0.9
Medication: Aspirin	0.6	0.8	1.2	-0.8	-0.7	-1.1
Supplements: Vitamin C	0.3	0.4	0.7	0.1	0.7	0.8
Knee pain experienced in last month	1.5	2.3	5.9	-2.4	1.0	0.0
Hypertension (Self-reported)	0.4	1.1	1.8	-1.1	0.4	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.9	-1.4	0.8	0.4
Illnesses of father: Heart disease	2.6	3.5	5.2	-2.3	-1.9	-1.4
Illnesses of siblings: Diabetes	1.5	1.8	4.2	0.2	-2.0	-1.1
Smoking status: Previous	0.0	0.1	0.1	0.1	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.8	-0.4	0.9	0.7
Whole body fat-free mass	0.6	3.6	8.4	1.2	-1.1	2.9
Leg fat-free mass (right)	0.6	3.0	5.2	1.5	-1.2	2.3
Arm fat percentage (left)	0.5	2.2	6.1	0.7	-2.5	-0.1
Average weekly red wine intake	4.0	5.8	16.2	4.0	-0.7	0.9
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.6	0.3	-1.0	-1.3
Mood swings	0.3	0.5	0.9	-0.8	0.9	0.3
Loneliness, isolation	0.9	1.2	2.3	-1.5	0.9	0.7
Long-standing illness, disability or infirmity	0.6	0.9	2.0	0.0	-1.4	-0.9
Ever had bowel cancer screening	1.9	2.3	6.3	2.5	-0.2	0.7
Diabetes diagnosed by doctor	0.3	0.4	0.6	-0.6	0.6	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.5	-0.7	0.7	0.7
Friendships satisfaction	0.4	0.4	1.1	0.4	0.3	1.1
Qualifications: nursing, teaching	1.0	1.5	2.7	0.9	-1.6	-1.0
Commuting to job workplace: Walk	1.0	1.0	2.5	0.6	-1.6	0.4
Eye problems/disorders: Cataract	2.1	2.4	6.8	2.6	0.3	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	0.5	-0.3	0.3
Medication for cholesterol	1.1	1.7	4.1	0.0	-1.0	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.8	-2.0	0.2	-0.5
Back pain experienced in last month	0.5	0.8	1.3	-1.1	-0.6	-0.8
Mineral and other dietary supplements	0.6	0.8	2.0	-0.5	-0.3	1.4
Breast cancer (self-reported)	1.6	1.9	3.7	1.2	-1.9	-0.7
Asthma (self-reported)	0.6	1.2	2.7	1.6	0.9	-0.2
Osteoporosis (self-reported)	0.1	0.2	0.4	0.7	0.3	0.0
Osteoarthritis (self-reported)	1.5	2.0	5.1	0.5	-2.3	-0.8
Medication: Aspirin	0.5	0.7	1.1	-0.1	-1.0	-1.0
Medication: Gliclazide	0.3	0.3	0.7	-0.8	0.5	0.2
Illnesses of father: None of the above (group 1)	0.7	0.9	2.4	0.1	1.6	0.5
Smoking status: Current	1.8	2.9	6.9	-2.6	0.3	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.9	0.8	1.4	-0.1
Whole body water mass	0.7	3.8	8.7	1.1	-1.2	3.0
Leg predicted mass (right)	0.5	2.9	5.0	1.5	-1.2	2.2
Arm fat mass (left)	0.4	1.8	3.5	0.6	-1.9	1.2
Number of self-reported non-cancer illnesses	0.8	1.4	3.7	0.6	-1.9	-0.2
Average weekly champagne plus white wine intake	2.2	3.1	9.1	3.0	0.1	0.3
Miserableness	0.4	0.7	1.3	-1.2	0.7	-0.6
Guilty feelings	0.9	1.4	3.9	-2.0	-0.0	-0.6
Wears glasses or contact lenses	0.3	0.3	0.7	-0.1	-0.8	-0.5
Ever taken oral contraceptive pill	2.7	3.0	8.4	0.7	2.9	0.6
Hearing aid user	0.5	0.6	1.8	0.1	1.4	0.0
Mother’s age at death	1.1	1.4	4.1	0.4	-2.0	-0.2
Financial situation satisfaction	3.4	4.2	10.3	-3.2	1.5	0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	-1.0	0.7	-0.2
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.1	-0.4	0.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.3	-0.8	1.1	-0.1
Medication: Blood pressure	0.3	0.6	1.6	-0.6	-0.1	1.3
Pain type(s) experienced in last month: Hip pain	2.0	2.5	4.0	-0.9	-1.7	-2.0
Supplements: Fish oil (including cod liver oil)	0.9	1.2	3.2	0.7	0.1	-1.8
High cholesterol (Self-reported)	0.9	1.6	3.8	1.0	-0.4	1.9
Medication: Bendroflumethiazide	0.4	0.5	0.8	-0.9	0.9	0.2
Medication: Paracetamol	0.4	0.6	1.7	-1.3	-0.2	0.2
Medication: Lisinopril	0.7	1.0	1.8	-0.6	0.8	1.4
Medication: Atorvastatin	1.6	1.9	5.4	0.5	0.4	2.3
Illnesses of father: High blood pressure	0.7	0.9	2.3	1.5	-0.6	-0.1
Alcohol drinker status: Never	0.9	1.1	3.0	-0.4	0.4	1.7
Ever smoked	0.5	1.0	2.6	0.5	-0.2	-1.6
Basal metabolic rate	0.6	3.3	8.0	0.8	-1.1	2.8
Leg fat percentage (left)	0.5	1.6	4.2	-0.5	-2.1	0.6
Arm fat-free mass (left)	0.7	3.8	10.5	0.4	-0.8	3.2
Number of operations (self-reported)	1.9	2.8	5.7	0.6	-2.4	-1.6
Average weekly beer plus cider intake	1.1	1.6	2.8	-1.7	1.4	-0.2
Irritability	0.1	0.1	0.2	-0.2	-0.2	-0.4
Risk taking	0.2	0.2	0.4	0.5	0.6	-0.3
Ever had prostate specific antigen (PSA) test	2.4	2.7	6.9	0.8	-2.6	0.8
Fractured/broken bones in last 5 years	0.2	0.3	0.7	0.5	0.8	-0.1
Age started oral contraceptive pill	1.6	2.0	5.8	2.4	-0.3	-0.0
Diastolic blood pressure, automated reading	1.1	3.3	8.6	-2.9	0.4	1.1
Ever depressed for a whole week	1.0	1.3	2.3	0.8	0.9	1.5
Unable to work because of sickness or disability	0.3	0.4	0.9	1.0	-0.4	-0.3
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.5	0.1	0.1
Myopia	1.5	2.2	5.2	1.1	-2.3	-0.3
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.5	1.6	0.9	-0.3
Cholesterol lowering medication	0.9	1.3	2.6	1.6	-0.6	1.1
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	4.0	-0.8	-2.0	-1.1
Pain experienced in last month	1.4	2.3	5.0	2.2	-1.4	0.4
Supplements: Calcium	1.2	1.4	3.8	2.0	-0.5	0.3
Basal cell carcinoma (self-reported)	1.0	1.1	2.8	0.8	-0.2	1.7
Heart attack/myocardial infarction (self-reported)	0.7	1.0	2.7	-0.4	-1.6	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.2	0.6	0.3	1.1
Heart disease (siblings)	0.0	0.1	0.1	0.2	0.2	0.2
Alcohol drinker status: Previous	1.5	1.7	3.5	1.9	1.2	0.1
Pack years of smoking	0.3	0.4	0.5	-0.7	0.6	0.5
Impedance of whole body	0.6	3.2	6.7	-1.5	0.9	-2.6
Leg fat mass (left)	0.5	1.9	3.5	0.1	-1.9	1.5
Arm predicted mass (left)	0.7	3.3	9.3	0.3	-0.8	3.0