Best TWAS P=6.39e-14 · Best GWAS P=2.85e-11 conditioned to 0.0508
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | NOA1 | 0.17 | 0.06 | lasso | 4 | 0.06 | 3.5e-04 | -6.0 | 6.0 | 1.5e-09 | -0.46 | 0.13 | 0.72 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | REST | 0.13 | 0.04 | enet | 19 | 0.04 | 1.1e-03 | 5.0 | 5.3 | 1.3e-07 | -0.23 | 0.27 | 0.50 | FALSE |
| 3 | GTEx | Colon Transverse | REST | 0.26 | 0.04 | lasso | 9 | 0.10 | 1.9e-05 | 5.7 | 7.5 | 8.0e-14 | -0.65 | 0.02 | 0.94 | FALSE |
| 4 | GTEx | Muscle Skeletal | REST | 0.05 | 0.01 | enet | 9 | 0.02 | 3.9e-03 | 4.1 | 6.2 | 7.4e-10 | -0.43 | 0.19 | 0.73 | FALSE |
| 5 | GTEx | Testis | REST | 0.15 | 0.08 | enet | 12 | 0.04 | 7.4e-03 | 5.5 | 5.2 | 1.6e-07 | -0.15 | 0.31 | 0.55 | FALSE |
| 6 | GTEx | Thyroid | NOA1 | 0.08 | 0.03 | lasso | 5 | 0.03 | 1.7e-03 | 6.1 | 5.7 | 1.6e-08 | -0.16 | 0.15 | 0.68 | FALSE |
| 7 | METSIM | Adipose | RP11-738E22.3 | 0.07 | 0.04 | lasso | 6 | 0.05 | 7.7e-08 | 6.1 | -6.9 | 5.0e-12 | 0.46 | 0.17 | 0.83 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C4orf14 | 0.03 | 0.04 | lasso | 3 | 0.04 | 1.9e-05 | 5.4 | 5.5 | 3.8e-08 | -0.37 | 0.18 | 0.40 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | REST | 0.04 | 0.01 | lasso | 5 | 0.02 | 7.8e-04 | 6.1 | 7.5 | 6.4e-14 | -0.70 | 0.05 | 0.76 | TRUE |