Best TWAS P=1.84e-82 · Best GWAS P=1.67e-81 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LIN54 | 0.06 | 0.08 | lasso | 2 | 0.07 | 1.1e-08 | -5.7 | 5.8 | 8.0e-09 | 0.05 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SCD5 | 0.28 | 0.40 | enet | 15 | 0.41 | 5.8e-54 | -14.2 | -15.9 | 4.3e-57 | 0.78 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | THAP9-AS1 | 0.08 | 0.05 | lasso | 2 | 0.04 | 1.7e-04 | 6.1 | -6.1 | 1.3e-09 | 0.12 | 0.66 | 0.01 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | THAP9-AS1 | 0.13 | 0.12 | lasso | 6 | 0.09 | 1.4e-05 | 6.2 | -6.6 | 5.2e-11 | 0.12 | 0.95 | 0.00 | FALSE |
| 5 | GTEx | Adrenal Gland | THAP9-AS1 | 0.20 | 0.07 | lasso | 4 | 0.04 | 1.8e-02 | 6.3 | -6.0 | 2.1e-09 | 0.13 | 0.22 | 0.04 | FALSE |
| 6 | GTEx | Artery Aorta | THAP9-AS1 | 0.19 | 0.14 | enet | 13 | 0.17 | 1.3e-09 | 6.1 | -5.8 | 7.5e-09 | 0.09 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Artery Coronary | ENOPH1 | 0.25 | 0.02 | lasso | 4 | 0.03 | 4.7e-02 | 5.3 | -5.7 | 1.4e-08 | 0.13 | 0.07 | 0.05 | FALSE |
| 8 | GTEx | Artery Tibial | THAP9-AS1 | 0.25 | 0.25 | lasso | 6 | 0.24 | 4.2e-19 | 6.1 | -6.0 | 2.6e-09 | 0.11 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Brain Cerebellar Hemisphere | THAP9-AS1 | 0.18 | 0.13 | lasso | 2 | 0.08 | 4.0e-03 | 5.6 | -5.5 | 3.0e-08 | 0.08 | 0.27 | 0.04 | FALSE |
| 10 | GTEx | Brain Cortex | THAP9-AS1 | 0.23 | 0.04 | lasso | 4 | 0.06 | 1.1e-02 | 6.1 | -6.4 | 1.3e-10 | 0.12 | 0.18 | 0.08 | FALSE |
| 11 | GTEx | Brain Frontal Cortex BA9 | THAP9-AS1 | 0.18 | 0.13 | lasso | 8 | 0.13 | 2.3e-04 | 6.1 | -6.1 | 1.1e-09 | 0.12 | 0.38 | 0.04 | FALSE |
| 12 | GTEx | Brain Hippocampus | THAP9-AS1 | 0.31 | 0.15 | lasso | 5 | 0.10 | 2.3e-03 | 5.3 | -5.1 | 2.8e-07 | 0.11 | 0.18 | 0.05 | FALSE |
| 13 | GTEx | Breast Mammary Tissue | THAP9-AS1 | 0.16 | 0.12 | lasso | 6 | 0.11 | 2.7e-06 | -5.4 | -6.1 | 9.3e-10 | -0.04 | 0.94 | 0.00 | FALSE |
| 14 | GTEx | Breast Mammary Tissue (Female) | THAP9-AS1 | 0.07 | 0.07 | lasso | 1 | 0.02 | 8.4e-02 | -5.4 | -5.4 | 5.2e-08 | -0.05 | 0.07 | 0.32 | FALSE |
| 15 | GTEx | Cells EBV-transformed lymphocytes | SCD5 | 0.31 | 0.11 | enet | 8 | 0.11 | 1.9e-04 | 5.5 | 5.5 | 4.2e-08 | -0.07 | 0.83 | 0.01 | FALSE |
| 16 | GTEx | Cells EBV-transformed lymphocytes | THAP9-AS1 | 0.14 | 0.10 | lasso | 3 | 0.12 | 7.0e-05 | 6.3 | -5.2 | 2.6e-07 | 0.14 | 0.37 | 0.03 | FALSE |
| 17 | GTEx | Cells Transformed fibroblasts | SCD5 | 0.17 | 0.02 | lasso | 11 | 0.13 | 5.4e-10 | 5.3 | 8.2 | 1.9e-16 | -0.56 | 0.12 | 0.87 | FALSE |
| 18 | GTEx | Cells Transformed fibroblasts | THAP9-AS1 | 0.33 | 0.37 | lasso | 9 | 0.36 | 2.1e-28 | 6.1 | -6.2 | 6.4e-10 | 0.12 | 1.00 | 0.00 | FALSE |
| 19 | GTEx | Colon Transverse | THAP9-AS1 | 0.14 | 0.02 | lasso | 2 | 0.05 | 2.6e-03 | 6.1 | -6.2 | 7.0e-10 | 0.08 | 0.16 | 0.06 | FALSE |
| 20 | GTEx | Esophagus Muscularis | TMEM150C | 0.17 | 0.01 | lasso | 9 | 0.02 | 1.4e-02 | -19.1 | 17.0 | 1.9e-64 | -0.89 | 0.01 | 0.94 | FALSE |
| 21 | GTEx | Heart Left Ventricle | TMEM150C | 0.21 | 0.11 | lasso | 3 | 0.07 | 1.0e-04 | -19.1 | 19.2 | 1.8e-82 | -0.98 | 0.01 | 0.99 | TRUE |
| 22 | GTEx | Lung | THAP9-AS1 | 0.07 | 0.05 | lasso | 4 | 0.03 | 3.9e-03 | 6.2 | -6.1 | 9.2e-10 | 0.13 | 0.63 | 0.02 | FALSE |
| 23 | GTEx | Muscle Skeletal | TMEM150C | 0.16 | 0.02 | lasso | 4 | 0.06 | 2.2e-06 | -19.1 | 16.5 | 3.7e-61 | -0.76 | 0.01 | 0.99 | FALSE |
| 24 | GTEx | Muscle Skeletal | THAP9-AS1 | 0.11 | 0.12 | lasso | 5 | 0.12 | 1.4e-11 | 6.1 | -6.1 | 1.1e-09 | 0.12 | 1.00 | 0.00 | FALSE |
| 25 | GTEx | Nerve Tibial | THAP9-AS1 | 0.08 | 0.00 | enet | 7 | 0.01 | 5.3e-02 | 6.3 | -7.2 | 6.8e-13 | 0.07 | 0.17 | 0.18 | TRUE |
| 26 | GTEx | Pituitary | TMEM150C | 0.39 | 0.10 | lasso | 7 | 0.15 | 1.6e-04 | -14.1 | 11.5 | 1.1e-30 | -0.53 | 0.09 | 0.33 | FALSE |
| 27 | GTEx | Testis | THAP9-AS1 | 0.21 | 0.12 | enet | 21 | 0.16 | 8.8e-08 | 6.1 | -6.2 | 6.0e-10 | 0.08 | 0.97 | 0.00 | FALSE |
| 28 | GTEx | Thyroid | TMEM150C | 0.12 | 0.05 | lasso | 5 | 0.08 | 6.6e-07 | -19.1 | 16.9 | 2.4e-64 | -0.87 | 0.01 | 0.99 | FALSE |
| 29 | GTEx | Whole Blood | COPS4 | 0.13 | 0.01 | lasso | 4 | 0.01 | 3.5e-02 | -14.1 | 14.6 | 2.4e-48 | -0.76 | 0.04 | 0.26 | FALSE |
| 30 | GTEx | Whole Blood | SCD5 | 0.11 | 0.02 | enet | 1 | 0.01 | 2.0e-02 | 5.5 | 5.5 | 4.2e-08 | -0.07 | 0.21 | 0.05 | FALSE |
| 31 | METSIM | Adipose | SCD5 | 0.11 | 0.05 | enet | 24 | 0.09 | 5.8e-14 | 3.8 | 5.1 | 2.8e-07 | -0.09 | 1.00 | 0.00 | FALSE |
| 32 | METSIM | Adipose | TMEM150C | 0.05 | 0.00 | blup | 470 | 0.02 | 9.9e-04 | -15.8 | 6.6 | 5.1e-11 | -0.54 | 0.04 | 0.90 | FALSE |
| 33 | NTR | Blood | HNRPDL | 0.03 | 0.00 | bslmm | 454 | 0.00 | 4.3e-02 | 1.7 | 6.7 | 2.8e-11 | -0.41 | 0.04 | 0.11 | FALSE |
| 34 | ROSMAP | Brain Pre-frontal Cortex | SCD5 | 0.22 | 0.15 | lasso | 9 | 0.17 | 7.8e-21 | -19.0 | 18.0 | 1.5e-72 | -0.93 | 0.01 | 0.99 | FALSE |
| 35 | ROSMAP | Brain Pre-frontal Cortex | THAP9-AS1 | 0.24 | 0.29 | bslmm | 463 | 0.33 | 3.8e-44 | 6.1 | -6.5 | 8.6e-11 | 0.09 | 1.00 | 0.00 | FALSE |
| 36 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMEM150C | 0.10 | 0.07 | enet | 13 | 0.09 | 9.4e-11 | -12.7 | 14.3 | 1.2e-46 | -0.58 | 0.00 | 1.00 | FALSE |
| 37 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TMEM150C | 0.12 | 0.12 | enet | 4 | 0.09 | 6.9e-06 | 4.8 | 6.8 | 1.0e-11 | -0.23 | 0.82 | 0.02 | FALSE |
| 38 | The Cancer Genome Atlas | Brain Lower Grade Glioma | THAP9 | 0.03 | 0.03 | lasso | 1 | 0.02 | 7.2e-04 | 6.1 | -6.1 | 1.1e-09 | 0.12 | 0.01 | 0.91 | FALSE |
| 39 | The Cancer Genome Atlas | Prostate Adenocarcinoma | THAP9 | 0.04 | 0.04 | blup | 50 | 0.04 | 7.8e-05 | 6.1 | -5.1 | 2.8e-07 | 0.11 | 0.01 | 0.98 | FALSE |
| 40 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM150C | 0.12 | 0.07 | lasso | 4 | 0.08 | 3.8e-08 | -16.0 | 16.2 | 1.1e-58 | -0.74 | 0.00 | 1.00 | FALSE |