Best TWAS P=2.38e-10 · Best GWAS P=4.09e-13 conditioned to 0.000253
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AK2 | 0.02 | 0.02 | blup | 332 | 0.02 | 5.0e-03 | -3.9 | 5.3 | 1.2e-07 | 0.48 | 0.20 | 0.12 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | ZNF362 | 0.05 | 0.06 | lasso | 1 | 0.06 | 2.2e-07 | 6.1 | 6.1 | 1.0e-09 | 0.77 | 0.22 | 0.78 | FALSE |
| 3 | GTEx | Brain Cerebellum | ADC | 0.17 | 0.03 | enet | 20 | 0.06 | 5.9e-03 | -3.1 | -5.3 | 1.3e-07 | -0.54 | 0.12 | 0.15 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | PHC2 | 0.58 | 0.34 | lasso | 7 | 0.28 | 7.3e-10 | 5.9 | -6.3 | 2.4e-10 | -0.80 | 0.35 | 0.65 | TRUE |
| 5 | GTEx | Muscle Skeletal | ZNF362 | 0.04 | 0.01 | enet | 7 | 0.02 | 4.9e-03 | -4.6 | 5.9 | 3.7e-09 | 0.70 | 0.08 | 0.76 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PHC2 | 0.11 | 0.07 | lasso | 3 | 0.05 | 2.2e-07 | 5.9 | 6.2 | 7.1e-10 | 0.81 | 0.76 | 0.24 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZNF362 | 0.03 | 0.01 | blup | 49 | 0.01 | 1.3e-03 | -5.3 | 5.4 | 5.6e-08 | 0.55 | 0.01 | 0.37 | FALSE |