Hub : Genes

ADC

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.1670 0.0720 1.8e-03 0.027 NA 0.064 NA 0.018 5.5e-02 NA 5.9e-03 NA 9.5e-02
2 GTEx Cells EBV-transformed lymphocytes 0.3850 0.0930 4.0e-08 0.117 NA 0.248 NA 0.226 1.2e-04 NA 1.2e-08 NA 6.3e-08
3 GTEx Cells Transformed fibroblasts 0.1010 0.0420 7.1e-03 0.021 NA 0.001 NA 0.006 1.0e-02 NA 2.4e-01 NA 1.1e-01
4 GTEx Skin Sun Exposed Lower leg 0.0810 0.0390 8.5e-04 0.027 NA 0.018 NA 0.012 2.5e-03 NA 1.1e-02 NA 3.2e-02
5 METSIM Adipose 0.0385 0.0168 3.4e-04 0.014 0.019 0.013 0.018 0.018 2.9e-03 6.6e-04 3.4e-03 7.3e-04 9.7e-04
6 ROSMAP Brain Pre-frontal Cortex 0.1225 0.0503 1.6e-04 0.089 0.036 0.106 0.085 0.109 1.4e-11 1.8e-05 1.6e-13 4.7e-11 7.5e-14
7 TCGA Breast Invasive Carcinoma 0.0269 0.0198 9.5e-03 0.007 0.005 0.008 NA 0.011 1.3e-02 2.6e-02 6.5e-03 NA 1.6e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.4 0.6 1.0 -1.0 -0.9 0.9 -1.0 -0.9 0.1 0.0
Bipolar Disorder or Schizophrenia 0.1 0.3 1.1 -0.1 -1.0 0.4 -0.9 -0.3 -0.0 0.0
Depressed Affect (Nagel 2018) 1.4 3.0 8.2 -1.1 -1.7 -0.1 -1.6 -2.1 1.4 2.9
Depression (Nagel 2018) 1.7 2.5 6.5 -1.6 -2.1 0.1 -1.3 -2.5 -0.5 1.4
Intelligence (Savage-Jansen 2018) 0.2 0.6 2.2 -0.6 -0.2 0.6 0.4 0.5 0.9 1.5
Neuroticism (Nagel 2018) 0.8 1.9 4.3 -0.8 -1.3 -0.7 -2.1 -1.3 1.0 1.8
Schizophrenia (2018) 0.1 0.2 0.5 0.7 -0.6 -0.2 -0.4 0.3 0.3 0.0
Schizophrenia vs Biploar Disorder 0.4 0.5 1.3 -0.2 0.3 -0.6 0.9 1.2 1.0 0.0
Worry (Nagel 2018) 0.3 0.6 0.9 -0.1 -0.9 -0.9 -1.0 0.5 1.0 0.6
Alzheimer’s Disease (in mother) 0.5 0.5 1.8 -0.6 -0.9 1.4 -0.0 -0.2 -0.8 -0.0
Alzheimer’s Disease (in father) 0.5 0.5 1.4 -1.0 0.1 -1.2 -0.3 0.7 0.6 0.6
Alzheimer’s Disease (including proxy) 0.4 0.5 1.7 -1.3 -1.1 -0.1 -0.4 0.0 -0.7 0.5
Crohns Disease (2017) 0.2 0.4 1.7 1.3 -0.3 -0.1 -0.1 0.4 0.1 0.7
Irritable Bowel Disease (IBD) 0.6 1.3 4.8 2.2 -0.6 -0.0 0.9 0.9 1.2 1.0
Ulcerative Colitis (UC) 0.8 1.6 5.0 2.2 -0.2 0.1 1.6 1.2 1.4 0.3
Major Depression (MDD) 1.3 1.6 5.3 0.7 -2.3 -0.6 -0.5 -0.1 1.5 1.6
Reaction Time 0.8 1.5 3.8 -0.5 -1.2 1.4 1.1 -0.1 -1.4 -2.0
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.1 -1.1 0.1 0.8 0.6 0.5 0.1 0.7
Breast Cancer 0.5 1.3 4.4 1.7 1.1 -0.2 0.5 0.7 2.1 0.3
Ovarian Cancer 0.3 0.4 0.9 0.7 -0.5 -0.3 -0.9 0.1 0.6 0.8
Prostate Cancer 0.7 0.9 3.3 0.1 0.9 -1.2 0.5 1.8 0.1 -0.9
Age at First Birth 0.9 1.3 2.9 1.1 1.7 -1.4 0.7 0.8 1.4 0.0
Bipolar Disorder (2011) 0.7 0.7 2.4 0.0 -1.6 1.5 0.1 -0.2 -0.4 0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.5 0.3 -0.2 0.5 0.7 -0.1 0.1 0.0
Coronary Artery Disease (CAD) 1.0 1.2 2.6 1.2 1.6 0.8 1.3 0.4 1.4 0.0
Crohns Disease (2012) 0.5 0.9 2.0 0.7 -1.4 0.7 -0.8 -0.5 0.3 1.4
Mean Putamen Volume 0.2 0.2 0.7 0.2 0.5 -0.5 -0.3 0.8 0.2 -0.0
Fasting Glucose 0.8 0.9 1.9 1.0 -1.1 1.4 -0.8 -0.8 1.0 0.0
HbA1C 1.5 1.7 6.0 0.9 0.5 1.5 2.5 1.5 0.3 0.0
HDL Cholesterol 1.0 1.6 4.4 -1.2 -1.1 -0.3 -2.1 -1.8 -1.0 0.0
LDL Cholesterol 0.8 1.3 2.6 -1.2 -1.3 -0.8 -1.5 -1.6 -0.6 0.0
Lupus 0.4 0.7 2.2 0.8 1.5 -0.3 -0.4 -0.3 -0.6 -1.0
Neuroticism (2016) 2.2 3.2 10.3 -0.3 -2.0 0.5 -3.2 -2.3 -1.6 0.0
Primary Biliary Cirrhosis 0.4 0.6 3.2 -1.8 -0.5 -0.3 0.0 0.2 -1.0 -0.0
Rheumatoid Arthritis 0.2 0.3 1.0 -0.1 -0.7 0.4 -0.1 -0.1 1.0 0.7
Schizophrenia (2014) 0.1 0.2 0.9 -0.2 -0.7 0.9 -0.6 0.1 0.0 0.0
Triglycerides 0.1 0.2 0.4 0.5 0.2 0.5 0.5 -0.6 -0.3 0.0
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.3 -0.3 -1.1 0.7 -0.5 0.4 -0.3 0.0
Ulcerative Colitis 0.8 1.1 3.0 1.7 -1.0 1.3 1.0 -0.0 1.1 0.4
Blood Eosinophil Count 1.1 8.8 27.8 -5.3 -3.0 -1.0 -3.1 -2.9 -2.4 1.0
Blood Platelet Count 0.1 1.4 5.0 1.4 0.1 -0.4 2.2 -1.4 0.9 0.4
Blood Red Count 0.9 8.9 20.7 -3.5 -4.3 -1.4 -4.5 -2.3 -1.4 1.3
Blood White Count 0.2 1.3 6.9 -0.2 -0.9 -2.6 0.8 0.2 0.5 0.4
Heel T-Score 0.3 2.3 5.5 -1.1 1.9 -1.2 -1.3 -1.0 -2.4 -1.2
BMI 0.4 2.4 5.3 2.2 0.8 -1.4 2.3 -0.8 1.3 1.4
Height 0.1 1.8 5.9 1.5 -2.4 0.9 0.5 -1.4 0.6 1.0
Waist Hip Ratio (WHR) 0.3 1.2 3.1 -1.3 -1.8 -0.7 -0.3 0.3 1.3 1.0
Systolic Blood Pressure 0.2 1.0 2.0 -1.4 -1.0 -0.5 -1.2 -1.2 0.1 1.1
Smoking Status 2.2 5.3 10.3 3.2 1.7 -3.0 3.2 1.1 0.7 -1.7
Allergy or Eczema 1.9 4.9 12.5 -1.9 -2.7 0.2 -2.7 -1.7 1.2 3.5
Cardiovascular Disease 0.9 3.0 9.7 -3.1 -1.6 0.6 -1.9 -0.8 -1.9 0.8
Hypothyroidism (self reported) 0.1 0.3 0.7 -0.3 -0.8 -0.1 -0.5 -0.5 0.3 0.9
Respiratory disease 1.3 2.8 5.8 -2.0 -2.3 -0.1 -1.8 -2.4 -0.1 1.1
Type 2 Diabetes (T2D) (2018) 0.5 0.9 3.3 0.4 0.6 1.0 1.8 -0.6 -0.9 -0.4
Lung FEV1/FVC ratio 1.3 6.7 15.9 4.0 3.3 -0.1 2.6 2.6 0.7 -2.5
Lung FVC 1.4 7.0 20.9 2.1 3.6 0.4 2.3 4.6 1.6 -1.6
Neuroticism 0.6 1.5 5.9 0.2 -0.5 -0.1 -1.2 0.1 2.4 1.7
Chronotype (morning person) 0.6 1.4 4.9 1.0 1.2 -0.0 1.3 2.2 0.0 -0.6
Hair Pigment 0.0 1.2 4.9 -0.2 2.2 -0.0 1.0 1.3 -0.4 -0.5
Tanning 0.2 2.3 4.6 1.6 1.5 1.4 2.1 1.5 0.9 -1.4
Hand grip strength (left) 1.0 2.7 6.9 2.6 -0.2 -0.6 2.4 2.0 0.2 -1.3
Number of treatments/medications taken 0.5 0.8 1.4 -0.9 -1.2 -0.7 -1.1 -1.2 -0.7 0.5
Average weekly spirits intake 0.5 0.6 1.3 1.1 0.4 -0.8 1.1 -0.9 0.3 0.3
Sensitivity / hurt feelings 0.8 1.4 3.3 0.9 1.1 -1.7 -1.1 -0.4 1.8 0.6
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.7 -1.3 -1.0 1.2 -0.1 -1.2 -0.5 0.0
Hearing difficulty/problems: Yes 0.8 1.2 2.5 -0.6 -0.9 1.3 -0.5 -1.6 0.5 1.5
Relative age of first facial hair 0.2 0.4 1.2 0.4 -0.0 0.6 -0.1 0.4 1.0 1.1
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 2.2 -0.5 -1.1 1.5 0.6 0.6 0.1 0.0
Ever used hormone-replacement therapy (HRT) 1.1 1.3 4.0 -2.0 -1.7 -0.4 -0.9 -0.4 -0.1 1.1
Ever had hysterectomy (womb removed) 0.5 0.6 2.1 0.9 0.3 0.0 0.9 0.0 1.4 0.6
Systolic blood pressure, automated reading 0.5 1.4 2.7 -1.6 -1.1 -0.3 -0.9 -1.3 0.9 1.6
Eye problems/disorders: Diabetes related eye disease 1.5 1.6 3.6 1.8 1.9 -1.9 0.2 0.6 0.1 -0.8
Angina 0.3 0.5 1.1 -1.1 -0.9 0.5 0.6 0.2 -0.1 0.8
Medication for hormone replacement therapy 0.4 0.5 1.4 -1.0 -0.9 -0.6 0.2 1.2 0.0 -0.1
Vitamin and mineral supplements 1.2 1.6 3.5 1.9 1.6 -0.2 0.6 1.6 0.4 -1.5
Supplements: Zinc 0.2 0.2 0.4 0.5 -0.2 0.6 -0.2 0.4 0.7 0.3
Medication: Co-codamol 0.4 0.5 2.6 -0.2 -0.5 -1.6 -0.4 -0.5 0.1 0.3
Medication: Metformin 0.4 0.5 2.1 0.0 1.1 -0.2 1.4 -0.6 -0.2 0.2
Diabetes (father) 0.5 0.6 2.0 0.4 -0.7 -0.6 0.0 -1.0 0.4 1.4
Diabetes (mother) 0.5 0.6 1.8 0.9 0.3 -1.3 0.6 0.8 0.5 -0.4
Severe depression (siblings) 1.6 1.8 4.8 1.4 0.7 -1.1 1.3 2.2 1.7 -0.0
Pack years adult smoking proportion 0.2 0.3 1.0 0.4 1.0 -0.2 -0.4 -0.3 0.7 0.2
Impedance of leg (right) 0.3 1.4 4.6 -2.1 -1.2 0.1 -1.7 -0.5 -0.6 -0.1
Leg fat-free mass (left) 0.6 3.2 11.0 3.3 0.7 -1.1 2.8 0.0 1.2 0.2
Trunk fat percentage 0.3 1.3 3.0 0.1 0.3 -1.7 1.4 -0.9 0.9 1.5
Hand grip strength (right) 0.2 0.5 1.5 1.2 -0.9 -0.1 0.7 0.5 -0.3 -0.2
Townsend deprivation index at recruitment 0.7 0.9 3.7 0.7 0.5 1.9 1.1 0.3 0.3 -0.8
Current tobacco smoking 2.2 3.7 6.6 2.5 1.7 -2.1 2.0 1.1 -0.2 -2.6
Average weekly fortified wine intake 0.4 0.5 2.3 -0.2 -0.2 -0.0 -0.2 -0.1 1.1 1.5
Maternal smoking around birth 0.8 1.2 3.4 1.3 1.2 -1.9 0.8 0.5 0.7 -0.6
Fed-up feelings 0.5 0.8 2.1 -0.3 -0.9 -0.4 -0.8 -1.2 0.8 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 4.2 -0.4 -0.8 1.1 -0.4 -2.1 0.5 1.6
Relative age voice broke 0.3 0.5 1.3 0.7 0.3 -0.9 0.8 0.4 1.1 0.5
Taking other prescription medications 1.7 2.5 6.6 -1.3 -1.8 -0.3 -2.0 -2.6 -1.2 1.0
Age when periods started (menarche) 1.6 3.7 7.1 2.7 2.4 -0.2 1.4 2.6 0.4 -2.1
Bilateral oophorectomy (both ovaries removed) 1.3 1.6 4.6 0.1 -0.6 0.8 -0.5 -2.1 1.3 1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 2.7 0.2 1.1 -1.6 0.5 -0.2 -0.4 -0.5
Tinnitus: Yes, but not now, but have in the past 1.9 2.0 4.3 -1.6 -1.1 0.9 -1.5 -2.1 -0.5 1.6
Qualifications: CSEs or equivalent 1.0 1.4 4.7 1.1 1.5 -0.5 0.6 0.4 -0.6 -2.2
Serious illness, injury or assault to yourself 1.2 1.4 5.6 -0.8 -0.9 -0.4 -2.4 -1.2 -1.1 -0.0
High blood pressure 0.4 1.0 4.2 -2.0 -0.8 0.0 0.3 0.3 -1.4 -0.2
Hayfever, allergic rhinitis or eczema 2.9 6.3 14.5 -1.7 -3.7 -0.4 -2.4 -2.0 1.7 3.8
Multivitamins +/- minerals 0.7 0.9 2.5 -1.1 -1.2 0.7 0.7 -1.6 -0.1 0.8
Stomach or abdominal pain in last month 0.6 0.8 2.2 0.7 -0.0 0.3 -0.9 -0.1 1.3 1.5
Supplements: Glucosamine 2.0 2.6 8.3 -0.7 -1.7 -0.8 -1.6 -2.9 -0.5 1.7
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.6 1.1 0.9 0.7 0.6 0.6 0.1 -1.3
Medication: Atenolol 0.9 1.1 3.5 0.1 1.0 0.5 1.9 1.5 0.7 0.4
Medication: Levothyroxine sodium 0.1 0.2 0.9 -0.3 -0.1 0.9 0.1 -0.5 0.3 0.1
Sitting height 0.2 1.5 3.8 1.8 0.5 -1.9 1.3 0.6 0.6 -0.7
Chronic bronchitis/emphysema (father) 1.4 1.6 3.7 1.0 0.8 -1.6 1.3 -0.2 -1.4 -1.9
High blood pressure (mother) 1.7 2.5 4.6 -1.9 -2.1 -0.4 -2.1 -0.9 -1.5 1.1
Body mass index (BMI) 0.7 2.9 6.2 1.6 0.9 -2.4 2.5 -1.2 1.4 1.3
Impedance of leg (left) 0.3 1.6 4.3 -2.1 -1.3 0.4 -2.0 -0.4 -0.7 -0.1
Leg predicted mass (left) 0.6 3.2 10.8 3.3 0.8 -1.0 2.8 -0.1 1.2 0.2
Trunk fat mass 0.5 2.0 4.5 1.1 0.3 -1.8 2.1 -0.9 1.3 1.5
Waist circumference 0.6 2.3 5.4 1.2 0.1 -1.8 2.3 -0.8 1.8 1.5
Number of incorrect matches in round 0.2 0.3 1.4 0.0 -0.1 0.7 0.4 -0.5 -0.2 -1.2
Past tobacco smoking 0.5 0.9 2.6 -1.2 0.3 1.2 -1.6 0.4 -0.3 -0.3
Alcohol usually taken with meals 0.3 0.5 3.0 0.0 -0.1 1.7 0.0 0.4 0.2 0.2
Nervous feelings 0.4 0.8 2.3 0.1 1.1 -1.5 -0.7 1.1 0.5 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 0.9 0.3 -0.8 -0.5 0.6 -0.2 0.9 0.7
Hearing difficulty/problems with background noise 0.6 0.9 1.7 -1.1 -0.7 -0.4 0.1 -1.3 1.1 1.3
Hair/balding pattern: Pattern 2 0.6 0.8 1.7 -1.2 0.3 -1.1 -0.3 0.1 1.3 0.9
Had menopause 0.7 0.9 2.7 -1.1 -0.8 -1.6 -0.9 -0.7 -0.5 0.7
Had other major operations 0.3 0.3 1.5 0.4 -0.6 -0.2 1.2 -0.1 0.5 0.3
Forced vital capacity (FVC) 1.3 5.1 11.0 3.1 2.6 -0.4 2.2 3.3 1.4 -1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.8 1.0 0.7 -1.3 -0.0 -0.2 -0.0 -0.2
Ever unenthusiastic/disinterested for a whole week 2.1 2.5 4.9 -0.7 -2.2 0.3 -2.1 -2.2 -0.8 1.6
Qualifications: None of the above 0.3 0.6 1.9 -1.2 -0.3 0.2 0.3 -1.4 0.6 0.7
Financial difficulties in last 2 years 2.2 2.9 5.5 2.3 1.5 0.6 2.2 1.4 2.4 -0.6
Mouth/teeth dental problems 0.3 0.4 2.1 1.4 -0.2 0.1 -0.1 -0.0 -0.4 -0.9
Heart attack 0.6 0.8 3.1 0.5 -0.1 -0.4 -0.4 -0.4 -1.8 -1.2
Allergy 2.1 4.8 16.2 1.5 4.0 0.5 1.7 2.1 -1.1 -2.5
Pain all over the body in last month 1.9 2.0 4.6 -1.8 -1.9 2.1 -0.1 -0.9 -0.2 1.3
Diabetes (self-reported) 0.4 0.7 2.0 0.5 1.4 0.2 1.4 -0.6 -0.3 -0.1
Hayfever/allergic rhinitis (self-reported) 3.3 4.3 11.6 -1.4 -2.7 -0.2 -2.1 -1.3 1.8 3.4
Medication: Ramipril 0.4 0.5 2.3 -1.5 0.3 -0.5 0.2 0.2 -0.7 -0.4
Medication: Simvastatin 0.6 0.9 2.9 -1.0 -0.5 1.7 1.1 1.0 -0.0 0.3
Fluid intelligence score 0.1 0.3 1.1 -0.4 0.5 0.1 0.2 1.0 -0.6 -0.1
Illnesses of siblings 0.4 0.5 1.2 0.6 0.4 0.5 0.3 0.9 -0.7 -1.1
Neuroticism score 0.4 0.9 3.8 0.4 0.1 0.2 -1.0 -0.0 1.9 1.2
Weight 0.8 3.8 8.9 2.7 0.5 -2.3 3.0 -0.8 1.7 1.1
Impedance of arm (right) 1.0 4.9 12.2 -3.4 -2.3 0.9 -3.5 -0.1 -2.0 -0.5
Arm fat percentage (right) 0.5 1.8 5.7 -0.1 -0.3 -2.4 1.0 -1.3 0.9 1.9
Trunk fat-free mass 0.8 4.5 15.4 3.9 0.8 -1.5 3.1 -0.0 1.8 0.4
Hip circumference 0.8 3.3 8.0 2.2 0.5 -1.9 2.8 -0.7 1.9 1.6
Time employed in main current job 0.6 0.7 1.8 -0.8 0.1 -1.0 -1.3 -0.7 -1.0 -0.5
Alcohol intake versus 10 years previously 0.3 0.4 1.6 0.6 0.4 -0.5 1.3 0.1 0.3 -0.3
Father’s age at death 0.7 1.0 4.0 0.0 0.7 2.0 0.4 -0.1 1.0 1.1
Worrier / anxious feelings 0.1 0.2 0.7 0.3 -0.2 -0.3 -0.3 -0.7 0.8 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 3.1 -0.6 -0.0 -1.5 -1.2 -1.8 0.0 0.1
Falls in the last year 0.6 0.8 3.1 1.7 0.6 -0.2 -1.1 -0.2 0.1 -1.0
Hair/balding pattern: Pattern 3 0.1 0.1 0.6 0.2 0.3 -0.2 -0.2 -0.2 0.4 0.8
Number of live births 0.7 1.0 5.6 -0.6 -0.2 -2.4 0.4 0.2 0.0 -0.6
Forced expiratory volume in 1-second (FEV1) 2.1 7.0 14.4 3.8 3.1 -1.2 2.4 3.8 1.2 -1.6
Pulse rate 0.3 0.5 1.5 0.4 0.4 -0.4 0.8 0.2 1.2 0.7
Happiness 1.3 1.6 4.5 1.3 -0.4 0.4 0.7 1.9 2.1 0.7
Noisy workplace 1.4 1.7 4.5 -1.2 -1.5 -0.1 -0.9 -2.1 -0.1 1.7
Qualifications: A levels/AS levels or equivalent 0.7 1.6 5.9 -1.0 -0.5 1.5 0.2 0.2 1.4 2.4
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.5 -0.1 -0.2 -0.2 0.7 -0.1 0.2 -0.1
Mouth/teeth dental problems: Dentures 0.3 0.6 3.1 -0.5 0.1 0.3 0.1 -0.4 -1.7 -0.6
Asthma 1.7 3.3 9.7 -1.5 -3.1 0.2 -1.4 -2.7 0.2 1.5
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 4.1 1.2 2.0 -0.8 0.8 1.1 0.7 -0.5
Medication: Cholesterol lowering 0.6 0.9 3.9 -1.4 0.0 2.0 0.3 0.1 -0.7 0.2
Depression (self-reported) 0.1 0.2 0.5 -0.2 -0.7 -0.7 0.4 0.1 0.2 0.1
Medication: Lansoprazole 0.6 0.7 2.2 0.6 0.2 -0.6 1.1 0.2 1.5 0.8
Prospective memory result 0.6 0.8 2.6 -0.1 0.5 0.7 0.7 0.5 -1.1 -1.6
Lung cancer (father) 1.2 1.4 3.2 0.5 1.7 -0.7 1.1 0.8 -1.0 -1.8
Illnesses of mother 4.5 5.6 14.1 3.8 3.1 -0.8 2.8 1.2 1.3 -2.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.9 6.0 16.9 4.1 2.1 -0.2 2.3 3.1 0.7 -2.3
Pulse wave Arterial Stiffness index 4.1 4.7 12.9 3.6 1.6 -3.0 1.8 1.6 0.4 -1.7
Impedance of arm (left) 0.8 3.9 9.4 -3.1 -1.9 1.6 -2.9 0.4 -1.6 -0.2
Arm fat mass (right) 0.6 2.5 6.3 1.3 0.4 -2.5 2.2 -1.1 1.3 1.4
Trunk predicted mass 0.8 4.5 15.1 3.9 0.8 -1.5 3.2 0.1 1.9 0.4
Standing height 0.2 1.5 7.2 2.7 -0.9 -0.2 1.4 0.3 0.7 -0.2
Length of working week for main job 3.4 3.7 7.0 2.6 2.0 0.1 2.5 2.2 1.3 -1.6
Exposure to tobacco smoke at home 1.5 1.7 3.6 1.2 1.3 0.7 1.9 0.9 -1.0 -1.7
Breastfed as a baby 0.3 0.4 0.8 0.3 0.9 0.2 0.9 0.9 -0.2 -0.6
Tense / ‘highly strung’ 0.4 0.6 1.4 0.4 -0.9 1.2 -0.7 0.6 -0.6 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 1.0 0.3 -0.7 -0.3 0.3 0.2 1.0 0.8
Hair/balding pattern: Pattern 4 0.7 1.7 5.1 1.1 2.2 0.1 0.6 0.9 -0.2 -2.0
Birth weight of first child 0.2 0.3 1.2 0.0 -0.2 0.3 -0.2 -0.9 0.2 1.1
Peak expiratory flow (PEF) 0.3 0.6 2.6 1.0 0.1 -1.6 0.7 -0.1 -0.6 -0.2
Pulse wave reflection index 1.1 1.4 5.8 2.4 0.6 -0.8 0.7 0.9 0.5 -1.1
Ever highly irritable/argumentative for 2 days 0.3 0.3 1.1 1.0 -0.4 -0.3 -0.4 -0.5 -0.7 -0.1
Loud music exposure frequency 0.9 1.0 2.9 1.3 0.9 0.7 1.7 0.8 -0.4 -0.6
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.6 -0.4 -0.8 -1.3 -1.1 -0.0 0.2 1.2
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 3.4 -0.5 -0.5 -0.7 0.7 0.6 1.8 0.9
Blood clot in the leg (DVT) 1.2 1.6 5.9 0.5 -0.2 -0.3 -0.2 -0.1 -2.2 -2.4
Medication: Paracetamol 0.3 0.4 1.2 -0.1 -1.0 -0.4 -0.7 -1.1 -0.1 0.1
Headache pain in last month 0.4 0.6 0.9 -0.2 -0.9 -0.9 -0.9 0.0 0.9 1.0
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.3 1.5 -0.4 -0.7 -0.5 -0.1 1.2 0.5
Glaucoma (self-reported) 0.9 1.0 2.9 1.3 0.8 0.5 1.1 0.7 -0.1 -1.7
Gout (self-reported) 0.3 0.5 1.3 -0.9 -0.3 0.9 1.1 -0.3 0.2 0.2
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.9 -1.0 -0.9 0.7 -0.2 -0.7 -0.1 0.4
Medication: Amlodipine 0.6 0.8 1.6 -1.0 1.0 0.1 0.4 1.0 -1.3 -0.7
Medication: Ventolin 100micrograms inhaler 1.4 1.8 5.1 -1.6 -1.9 -0.0 -0.7 -0.9 0.6 2.3
Birth weight 0.1 0.3 1.0 -0.2 0.1 0.2 0.4 -0.9 0.4 1.0
Chronic bronchitis/emphysema (mother) 0.8 1.0 2.5 -1.6 -0.6 1.4 -0.4 -0.4 0.4 1.2
High blood pressure (siblings) 0.1 0.2 0.8 -0.5 0.0 0.0 -0.4 -0.4 0.0 0.9
Forced vital capacity (FVC), Best measure 1.1 4.1 11.8 3.4 1.4 0.3 1.9 2.8 0.8 -1.8
Body fat percentage 0.5 1.8 4.1 0.2 0.4 -2.0 1.7 -0.9 1.3 1.7
Leg fat percentage (right) 0.7 2.6 5.7 0.5 0.5 -2.0 2.4 -0.9 1.9 1.8
Arm fat-free mass (right) 1.1 5.7 17.6 4.2 1.4 -1.3 3.9 0.1 2.0 0.3
Exposure to tobacco smoke outside home 0.9 1.3 4.3 -0.1 1.5 -0.9 2.1 0.7 1.0 0.2
Comparative body size at age 10 0.1 0.3 0.8 -0.6 0.5 0.5 0.4 -0.3 -0.9 -0.4
Number of full brothers 1.9 2.4 6.9 1.6 1.1 -0.9 2.6 1.7 1.5 -0.5
Worry too long after embarrassment 0.3 0.5 2.1 0.4 0.7 0.1 -1.4 0.5 0.1 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 2.4 3.1 9.1 -0.9 -3.0 0.5 -2.2 -2.2 -0.6 1.2
Wheeze or whistling in the chest in last year 1.0 1.8 4.7 0.7 -1.4 0.9 0.5 -0.6 2.1 2.2
Number of children fathered 1.5 1.7 5.4 0.2 -0.8 -1.3 -0.6 -1.3 1.4 2.3
Reason for reducing amount of alcohol drunk: Health precaution 1.7 2.0 5.7 1.1 0.6 1.0 1.7 1.6 -0.0 -2.4
Age at first live birth 0.1 0.2 0.7 -0.1 -0.6 -0.0 -0.8 -0.3 -0.3 0.4
Pulse wave peak to peak time 3.5 4.1 10.8 -3.3 -1.5 2.8 -1.7 -1.5 -0.4 1.6
Health satisfaction 0.5 0.6 1.9 0.9 -0.3 -1.2 -0.2 -0.2 1.4 0.5
Shortness of breath walking on level ground 0.4 0.4 1.6 1.3 -0.1 0.0 1.1 -0.1 0.6 0.1
Qualifications: College or University degree 0.3 0.8 3.3 -0.7 -0.9 1.8 -0.2 1.0 0.0 0.0
Eye problems/disorders: None of the above 0.2 0.3 0.8 -0.9 -0.4 0.2 0.6 0.4 -0.7 -0.3
Mouth/teeth dental problems: Loose teeth 0.7 0.9 3.2 -1.1 -0.3 1.8 0.1 -0.1 -1.1 0.6
Emphysema/chronic bronchitis 1.3 1.4 4.4 1.0 0.4 -0.9 2.1 1.2 0.3 -1.4
Medication for pain relief, constipation, heartburn 1.1 1.8 2.9 1.4 1.2 1.2 1.6 1.7 1.5 -0.4
Neck or shoulder pain in last month 0.4 0.6 1.3 -0.0 -0.8 -1.0 0.2 -1.2 -1.0 -0.7
Medication: Blood pressure 0.7 1.3 3.9 -0.9 0.9 -0.0 0.7 0.3 -2.0 -1.7
Angina (self-reported) 0.2 0.3 0.7 -0.8 -0.6 0.4 0.6 0.4 -0.3 0.5
Migraine (self-reported) 0.3 0.4 1.7 0.3 0.1 -1.3 -0.5 -0.8 -0.0 0.0
Medication: Ibuprofen 0.9 1.1 3.9 1.2 2.0 -1.2 0.5 0.5 0.4 -0.4
Medication: Allopurinol 0.3 0.4 1.4 -1.2 -0.3 -0.6 0.8 -0.1 0.1 0.5
Medication: Omeprazole 0.3 0.4 1.2 0.2 -0.6 -1.1 0.4 -0.9 0.0 0.5
Medication: Seretide 50 evohaler 2.1 2.4 5.2 -1.4 -1.6 0.4 -1.8 -1.7 0.8 2.3
Mean time to correctly identify matches 0.9 1.7 4.1 -2.0 -1.8 1.1 0.2 -1.1 -1.5 -0.4
Heart disease (mother) 0.7 0.8 3.4 -1.9 -0.7 -0.2 -1.1 -0.3 -0.2 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.6 4.6 0.7 1.4 0.0 2.1 1.5 0.4 -1.1
Whole body fat mass 0.6 2.4 4.5 1.3 0.4 -2.0 2.1 -1.0 1.6 1.7
Leg fat mass (right) 0.8 3.0 7.6 1.4 0.3 -2.0 2.8 -1.1 1.8 1.7
Arm predicted mass (right) 1.0 5.3 16.5 4.1 1.4 -1.2 3.7 -0.0 1.8 0.3
Pulse rate, automated reading 0.1 0.4 1.0 0.1 -0.7 0.2 -0.1 -0.2 0.9 1.0
Alcohol intake frequency. 0.9 2.1 5.5 -1.1 -1.5 0.7 -1.0 -1.4 1.5 2.4
Comparative height size at age 10 0.1 0.7 1.2 1.1 -1.0 -0.5 0.6 -0.6 0.8 1.1
Number of full sisters 0.8 1.0 2.9 0.9 0.6 -1.6 0.2 -0.1 -0.7 -1.7
Suffer from ‘nerves’ 0.2 0.4 1.0 -0.4 -0.8 -0.7 -0.5 1.0 0.1 -0.4
Overall health rating 0.6 1.3 2.8 -1.0 -0.8 -1.1 -0.8 -0.9 1.4 1.7
Chest pain or discomfort 1.3 1.9 6.8 -0.3 -1.0 -0.2 -0.1 -0.6 2.6 2.3
Had major operations 1.7 2.0 5.9 -0.8 -2.4 -0.7 -1.2 -1.9 -1.4 -0.2
Age at last live birth 0.2 0.2 0.6 0.1 -0.6 -0.7 0.0 0.1 0.3 0.8
Family relationship satisfaction 3.5 4.2 9.6 2.2 1.3 0.9 2.8 3.1 2.0 -0.9
Leg pain on walking 0.5 0.6 1.8 0.9 -0.5 0.7 -0.0 -1.4 -0.6 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.7 1.3 0.7 -0.6 0.2 0.5 -1.1 -1.3
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.3 0.9 -1.0 -1.0 -1.1 -0.9 0.3 1.1
Illness, injury, bereavement, stress in last 2 years 0.4 0.4 1.9 -0.2 -0.5 -0.6 -0.5 -0.3 -1.4 -0.4
Medication: Aspirin 0.4 0.5 1.4 -0.9 -0.7 0.2 -0.7 -0.7 -1.2 -0.1
Supplements: Vitamin C 0.7 0.8 3.6 -0.9 -0.4 -0.1 0.0 0.2 1.0 1.9
Knee pain experienced in last month 0.2 0.3 1.5 0.6 0.3 -0.1 0.2 -1.2 0.2 0.4
Hypertension (Self-reported) 0.6 1.5 5.0 -2.2 -1.1 0.4 -0.0 0.0 -2.0 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.0 2.4 9.9 -0.3 -0.6 -3.1 -1.4 -1.4 0.4 1.5
Illnesses of father: Heart disease 0.7 0.9 3.0 -0.7 -0.6 -0.1 -1.4 -1.7 -0.7 0.4
Illnesses of siblings: Diabetes 0.7 0.8 3.0 0.8 1.0 -0.6 1.7 -0.0 0.7 -0.5
Smoking status: Previous 0.3 0.4 1.3 1.1 -0.1 -0.4 1.0 -0.3 0.5 0.6
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.5 6.4 2.5 0.9 0.3 2.2 1.4 0.5 -1.6
Whole body fat-free mass 0.7 4.3 14.3 3.8 1.0 -1.3 3.2 0.1 1.6 0.3
Leg fat-free mass (right) 0.5 2.9 11.4 3.4 0.6 -0.6 2.7 0.2 1.1 0.0
Arm fat percentage (left) 0.4 1.7 4.0 0.3 0.2 -2.0 1.5 -0.8 1.2 1.9
Average weekly red wine intake 0.4 0.7 2.4 1.0 0.1 1.5 -0.1 -0.6 0.6 0.6
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.8 -0.3 -0.0 -0.0 0.4 0.4 -0.9 -0.5
Mood swings 0.9 1.7 4.1 -0.8 -1.5 0.9 -1.0 -2.0 0.5 1.6
Loneliness, isolation 0.4 0.6 2.7 0.7 0.5 0.0 0.2 0.6 1.6 0.5
Long-standing illness, disability or infirmity 0.2 0.3 0.8 -0.0 -0.6 0.4 0.2 0.8 0.9 0.5
Ever had bowel cancer screening 0.9 1.1 6.3 -0.2 0.1 -0.2 -2.5 -0.6 -0.9 -0.3
Diabetes diagnosed by doctor 0.2 0.3 1.0 -0.4 0.6 0.0 0.6 -1.0 -0.5 0.5
Ever had stillbirth, spontaneous miscarriage or termination 2.4 2.5 4.3 2.0 2.1 -1.4 1.1 1.7 1.0 -1.5
Friendships satisfaction 0.8 0.9 2.4 0.9 -0.1 1.4 0.1 1.5 0.5 -1.1
Qualifications: nursing, teaching 0.2 0.3 1.5 0.2 -0.5 1.2 0.5 0.5 -0.4 -0.2
Commuting to job workplace: Walk 0.7 0.7 1.6 -0.0 1.1 0.8 0.8 1.2 -0.3 -1.0
Eye problems/disorders: Cataract 0.5 0.6 1.3 0.6 1.1 0.8 -0.2 0.9 0.9 0.1
Mouth/teeth dental problems: Mouth ulcers 1.6 2.6 7.4 0.7 2.0 0.7 2.1 2.7 0.5 -1.2
Medication for cholesterol 1.5 2.3 7.2 2.7 2.5 0.1 1.4 -0.0 0.9 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 3.0 -1.7 -1.1 -0.7 -1.5 -1.4 -1.6 -0.3
Back pain experienced in last month 0.3 0.4 2.8 -0.3 -0.2 -1.7 -0.4 -0.0 -0.2 0.1
Mineral and other dietary supplements 0.8 1.0 4.7 1.3 0.4 -0.2 0.1 2.2 0.7 -0.5
Breast cancer (self-reported) 0.5 0.6 2.3 -0.4 -0.5 0.0 -0.4 -0.8 -1.5 -0.8
Asthma (self-reported) 1.4 2.8 8.9 -1.2 -3.0 -0.3 -1.4 -2.3 0.3 1.3
Osteoporosis (self-reported) 0.1 0.1 0.5 -0.7 -0.1 -0.1 0.1 0.2 -0.3 -0.4
Osteoarthritis (self-reported) 1.3 1.7 3.4 -1.3 -1.8 -0.1 -1.0 -1.8 -1.5 0.7
Medication: Aspirin 0.9 1.1 2.6 -1.3 -1.1 -0.4 -0.9 -1.1 -1.6 0.0
Medication: Gliclazide 0.7 0.7 1.3 -0.6 0.1 1.0 1.1 -0.4 -1.1 -1.0
Illnesses of father: None of the above (group 1) 0.5 0.6 1.7 0.8 0.2 0.3 0.9 1.3 0.9 -0.4
Smoking status: Current 2.4 3.9 6.5 2.4 1.7 -2.6 2.4 1.1 0.1 -2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.1 4.4 15.7 2.1 1.8 -0.2 2.1 4.0 1.3 -1.0
Whole body water mass 0.7 4.2 14.3 3.8 0.9 -1.2 3.3 -0.0 1.5 0.3
Leg predicted mass (right) 0.6 2.9 11.2 3.4 0.6 -0.6 2.7 0.2 1.1 0.1
Arm fat mass (left) 0.7 2.7 5.6 1.3 0.4 -2.4 2.2 -1.0 1.6 1.8
Number of self-reported non-cancer illnesses 2.6 4.6 10.2 -3.2 -3.1 -0.2 -1.8 -2.0 -1.9 1.1
Average weekly champagne plus white wine intake 0.3 0.5 2.3 -0.4 -0.3 1.5 -0.1 -0.1 -0.2 0.7
Miserableness 1.4 2.4 7.5 -1.7 -1.1 0.1 -0.7 -1.9 1.2 2.7
Guilty feelings 0.3 0.5 1.9 0.2 0.5 0.5 -0.4 0.5 1.4 0.8
Wears glasses or contact lenses 1.0 1.1 5.8 -0.2 -0.7 2.4 0.9 -0.8 -0.4 -0.1
Ever taken oral contraceptive pill 1.4 1.6 4.0 -1.2 1.3 0.1 1.0 0.2 1.6 2.0
Hearing aid user 2.1 2.3 7.5 -1.4 -1.7 -0.8 -0.5 -1.2 1.3 2.7
Mother’s age at death 1.3 1.6 4.3 -0.7 -1.9 0.1 -1.0 -0.6 1.2 2.1
Financial situation satisfaction 2.7 3.3 8.3 2.9 1.2 -1.1 2.2 1.8 1.5 -1.3
Tinnitus: Yes, now most or all of the time 1.2 1.4 3.5 -0.9 -1.6 0.5 -0.9 -1.1 0.8 1.9
Commuting to job workplace: Public transport 1.2 1.4 3.5 -1.1 -1.0 1.8 0.0 -0.9 0.6 1.9
Eye problems/disorders: Glaucoma 0.2 0.2 0.9 1.0 -0.1 -0.3 0.2 0.4 0.6 -0.4
Medication: Blood pressure 0.6 1.2 3.8 -1.9 -1.2 0.2 -1.4 -0.0 -1.2 0.1
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.7 0.5 0.4 -1.1 0.8 -0.7 -0.9 -1.3
Supplements: Fish oil (including cod liver oil) 0.7 0.9 4.3 -1.0 0.1 0.1 0.6 -2.1 0.1 0.6
High cholesterol (Self-reported) 1.4 2.4 7.9 -2.8 -0.8 2.2 -0.9 0.1 -1.6 0.5
Medication: Bendroflumethiazide 0.8 1.2 5.2 -1.2 -0.8 -0.3 -0.6 -0.3 -2.3 -0.8
Medication: Paracetamol 0.6 0.9 2.9 -0.5 -1.1 -0.6 -1.0 -1.7 -0.9 -0.1
Medication: Lisinopril 0.7 0.9 2.3 -0.2 -0.9 -1.5 -0.3 0.3 -1.5 -0.7
Medication: Atorvastatin 0.8 1.0 3.0 -0.8 -0.8 0.4 -1.7 -1.1 -1.1 0.4
Illnesses of father: High blood pressure 0.6 0.7 1.4 0.2 0.1 1.1 1.1 -0.2 -1.0 -1.2
Alcohol drinker status: Never 1.2 1.5 3.4 -1.7 -0.8 -0.0 -1.4 -1.0 -1.8 0.3
Ever smoked 0.4 0.7 2.2 1.1 -0.5 -1.0 1.5 -0.5 -0.2 -0.2
Basal metabolic rate 0.7 4.0 12.2 3.5 0.7 -1.6 3.1 -0.2 1.6 0.5
Leg fat percentage (left) 0.6 2.1 3.9 0.6 0.4 -1.7 2.0 -1.0 1.7 1.8
Arm fat-free mass (left) 0.8 4.1 11.9 3.5 0.7 -2.0 3.0 -0.7 1.7 0.6
Number of operations (self-reported) 1.0 1.5 4.2 -0.4 -2.1 -0.6 -1.4 -1.7 -1.0 0.2
Average weekly beer plus cider intake 1.0 1.5 3.5 1.1 1.4 -1.9 1.6 0.8 0.2 -0.8
Irritability 0.9 1.4 2.7 0.4 -1.1 1.6 -1.5 -1.4 -1.2 -0.6
Risk taking 0.3 0.5 1.8 1.3 -0.3 -0.8 -0.3 -0.7 -0.3 0.7
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.4 -0.3 0.2 -0.1 0.1 -0.4 -1.2 -0.8
Fractured/broken bones in last 5 years 1.1 1.4 4.2 -0.1 -2.0 1.8 -0.5 -1.1 -0.9 -0.6
Age started oral contraceptive pill 0.5 0.6 2.1 -1.4 -0.6 -0.5 -0.7 0.5 -0.7 -0.3
Diastolic blood pressure, automated reading 0.3 1.0 3.1 1.1 0.5 -0.5 1.2 0.2 1.8 1.0
Ever depressed for a whole week 0.6 0.8 2.2 0.1 -1.5 -0.4 -0.9 -0.4 0.6 1.3
Unable to work because of sickness or disability 0.5 0.7 1.6 0.2 1.3 1.3 0.9 -0.9 0.0 -0.0
Commuting to job workplace: Cycle 0.4 0.5 1.7 0.0 -0.5 0.4 -0.0 -0.8 0.8 1.3
Myopia 0.8 1.1 4.0 -1.6 0.9 2.0 0.4 0.6 -0.0 0.0
Vascular/heart problems diagnosed by doctor 0.4 1.2 4.1 2.0 0.8 0.1 -0.2 -0.3 1.8 0.3
Cholesterol lowering medication 0.8 1.2 3.9 -1.4 -2.0 0.1 -1.3 -0.4 -0.7 0.7
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.7 -0.3 -0.3 -1.3 0.1 -1.2 0.1 0.8
Pain experienced in last month 0.6 0.9 2.2 1.2 1.5 0.8 0.8 0.5 0.6 -0.9
Supplements: Calcium 0.4 0.5 2.6 -1.6 -0.2 -0.4 -0.3 -0.4 -0.4 0.2
Basal cell carcinoma (self-reported) 0.5 0.6 1.8 0.1 0.5 0.1 0.8 -0.9 -1.4 -0.8
Heart attack/myocardial infarction (self-reported) 0.6 0.8 3.3 0.3 -0.3 -0.5 -0.2 -0.3 -1.8 -1.2
Deep venous thrombosis (DVT) (self-reported) 1.2 1.5 5.0 0.3 -0.4 -0.2 -0.5 -0.4 -2.2 -2.2
Heart disease (siblings) 0.3 0.4 1.8 0.0 -1.3 -0.4 0.0 -0.6 -0.5 -0.6
Alcohol drinker status: Previous 2.1 2.4 6.2 -0.0 -1.6 1.8 1.1 -0.4 1.8 2.5
Pack years of smoking 0.2 0.3 0.8 0.1 0.9 -0.3 -0.4 -0.4 0.8 0.5
Impedance of whole body 0.6 2.9 8.0 -2.8 -1.5 0.9 -2.8 0.1 -1.1 -0.0
Leg fat mass (left) 0.7 2.7 6.0 1.3 0.2 -2.0 2.4 -1.2 1.6 1.7
Arm predicted mass (left) 0.9 4.5 12.7 3.6 1.1 -2.0 3.3 -0.5 1.7 0.3