Hub : Genes

ADC

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.1670	0.0720	1.8e-03	0.027	NA	0.064	NA	0.018	5.5e-02	NA	5.9e-03	NA	9.5e-02
2	GTEx	Cells EBV-transformed lymphocytes	0.3850	0.0930	4.0e-08	0.117	NA	0.248	NA	0.226	1.2e-04	NA	1.2e-08	NA	6.3e-08
3	GTEx	Cells Transformed fibroblasts	0.1010	0.0420	7.1e-03	0.021	NA	0.001	NA	0.006	1.0e-02	NA	2.4e-01	NA	1.1e-01
4	GTEx	Skin Sun Exposed Lower leg	0.0810	0.0390	8.5e-04	0.027	NA	0.018	NA	0.012	2.5e-03	NA	1.1e-02	NA	3.2e-02
5	METSIM	Adipose	0.0385	0.0168	3.4e-04	0.014	0.019	0.013	0.018	0.018	2.9e-03	6.6e-04	3.4e-03	7.3e-04	9.7e-04
6	ROSMAP	Brain Pre-frontal Cortex	0.1225	0.0503	1.6e-04	0.089	0.036	0.106	0.085	0.109	1.4e-11	1.8e-05	1.6e-13	4.7e-11	7.5e-14
7	TCGA	Breast Invasive Carcinoma	0.0269	0.0198	9.5e-03	0.007	0.005	0.008	NA	0.011	1.3e-02	2.6e-02	6.5e-03	NA	1.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.6	1.0	-1.0	-0.9	0.9	-1.0	-0.9	0.1	0.0
Bipolar Disorder or Schizophrenia	0.1	0.3	1.1	-0.1	-1.0	0.4	-0.9	-0.3	-0.0	0.0
Depressed Affect (Nagel 2018)	1.4	3.0	8.2	-1.1	-1.7	-0.1	-1.6	-2.1	1.4	2.9
Depression (Nagel 2018)	1.7	2.5	6.5	-1.6	-2.1	0.1	-1.3	-2.5	-0.5	1.4
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.2	-0.6	-0.2	0.6	0.4	0.5	0.9	1.5
Neuroticism (Nagel 2018)	0.8	1.9	4.3	-0.8	-1.3	-0.7	-2.1	-1.3	1.0	1.8
Schizophrenia (2018)	0.1	0.2	0.5	0.7	-0.6	-0.2	-0.4	0.3	0.3	0.0
Schizophrenia vs Biploar Disorder	0.4	0.5	1.3	-0.2	0.3	-0.6	0.9	1.2	1.0	0.0
Worry (Nagel 2018)	0.3	0.6	0.9	-0.1	-0.9	-0.9	-1.0	0.5	1.0	0.6
Alzheimer’s Disease (in mother)	0.5	0.5	1.8	-0.6	-0.9	1.4	-0.0	-0.2	-0.8	-0.0
Alzheimer’s Disease (in father)	0.5	0.5	1.4	-1.0	0.1	-1.2	-0.3	0.7	0.6	0.6
Alzheimer’s Disease (including proxy)	0.4	0.5	1.7	-1.3	-1.1	-0.1	-0.4	0.0	-0.7	0.5
Crohns Disease (2017)	0.2	0.4	1.7	1.3	-0.3	-0.1	-0.1	0.4	0.1	0.7
Irritable Bowel Disease (IBD)	0.6	1.3	4.8	2.2	-0.6	-0.0	0.9	0.9	1.2	1.0
Ulcerative Colitis (UC)	0.8	1.6	5.0	2.2	-0.2	0.1	1.6	1.2	1.4	0.3
Major Depression (MDD)	1.3	1.6	5.3	0.7	-2.3	-0.6	-0.5	-0.1	1.5	1.6
Reaction Time	0.8	1.5	3.8	-0.5	-1.2	1.4	1.1	-0.1	-1.4	-2.0
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.1	-1.1	0.1	0.8	0.6	0.5	0.1	0.7
Breast Cancer	0.5	1.3	4.4	1.7	1.1	-0.2	0.5	0.7	2.1	0.3
Ovarian Cancer	0.3	0.4	0.9	0.7	-0.5	-0.3	-0.9	0.1	0.6	0.8
Prostate Cancer	0.7	0.9	3.3	0.1	0.9	-1.2	0.5	1.8	0.1	-0.9
Age at First Birth	0.9	1.3	2.9	1.1	1.7	-1.4	0.7	0.8	1.4	0.0
Bipolar Disorder (2011)	0.7	0.7	2.4	0.0	-1.6	1.5	0.1	-0.2	-0.4	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.5	0.3	-0.2	0.5	0.7	-0.1	0.1	0.0
Coronary Artery Disease (CAD)	1.0	1.2	2.6	1.2	1.6	0.8	1.3	0.4	1.4	0.0
Crohns Disease (2012)	0.5	0.9	2.0	0.7	-1.4	0.7	-0.8	-0.5	0.3	1.4
Mean Putamen Volume	0.2	0.2	0.7	0.2	0.5	-0.5	-0.3	0.8	0.2	-0.0
Fasting Glucose	0.8	0.9	1.9	1.0	-1.1	1.4	-0.8	-0.8	1.0	0.0
HbA1C	1.5	1.7	6.0	0.9	0.5	1.5	2.5	1.5	0.3	0.0
HDL Cholesterol	1.0	1.6	4.4	-1.2	-1.1	-0.3	-2.1	-1.8	-1.0	0.0
LDL Cholesterol	0.8	1.3	2.6	-1.2	-1.3	-0.8	-1.5	-1.6	-0.6	0.0
Lupus	0.4	0.7	2.2	0.8	1.5	-0.3	-0.4	-0.3	-0.6	-1.0
Neuroticism (2016)	2.2	3.2	10.3	-0.3	-2.0	0.5	-3.2	-2.3	-1.6	0.0
Primary Biliary Cirrhosis	0.4	0.6	3.2	-1.8	-0.5	-0.3	0.0	0.2	-1.0	-0.0
Rheumatoid Arthritis	0.2	0.3	1.0	-0.1	-0.7	0.4	-0.1	-0.1	1.0	0.7
Schizophrenia (2014)	0.1	0.2	0.9	-0.2	-0.7	0.9	-0.6	0.1	0.0	0.0
Triglycerides	0.1	0.2	0.4	0.5	0.2	0.5	0.5	-0.6	-0.3	0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.3	-0.3	-1.1	0.7	-0.5	0.4	-0.3	0.0
Ulcerative Colitis	0.8	1.1	3.0	1.7	-1.0	1.3	1.0	-0.0	1.1	0.4
Blood Eosinophil Count	1.1	8.8	27.8	-5.3	-3.0	-1.0	-3.1	-2.9	-2.4	1.0
Blood Platelet Count	0.1	1.4	5.0	1.4	0.1	-0.4	2.2	-1.4	0.9	0.4
Blood Red Count	0.9	8.9	20.7	-3.5	-4.3	-1.4	-4.5	-2.3	-1.4	1.3
Blood White Count	0.2	1.3	6.9	-0.2	-0.9	-2.6	0.8	0.2	0.5	0.4
Heel T-Score	0.3	2.3	5.5	-1.1	1.9	-1.2	-1.3	-1.0	-2.4	-1.2
BMI	0.4	2.4	5.3	2.2	0.8	-1.4	2.3	-0.8	1.3	1.4
Height	0.1	1.8	5.9	1.5	-2.4	0.9	0.5	-1.4	0.6	1.0
Waist Hip Ratio (WHR)	0.3	1.2	3.1	-1.3	-1.8	-0.7	-0.3	0.3	1.3	1.0
Systolic Blood Pressure	0.2	1.0	2.0	-1.4	-1.0	-0.5	-1.2	-1.2	0.1	1.1
Smoking Status	2.2	5.3	10.3	3.2	1.7	-3.0	3.2	1.1	0.7	-1.7
Allergy or Eczema	1.9	4.9	12.5	-1.9	-2.7	0.2	-2.7	-1.7	1.2	3.5
Cardiovascular Disease	0.9	3.0	9.7	-3.1	-1.6	0.6	-1.9	-0.8	-1.9	0.8
Hypothyroidism (self reported)	0.1	0.3	0.7	-0.3	-0.8	-0.1	-0.5	-0.5	0.3	0.9
Respiratory disease	1.3	2.8	5.8	-2.0	-2.3	-0.1	-1.8	-2.4	-0.1	1.1
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.3	0.4	0.6	1.0	1.8	-0.6	-0.9	-0.4
Lung FEV1/FVC ratio	1.3	6.7	15.9	4.0	3.3	-0.1	2.6	2.6	0.7	-2.5
Lung FVC	1.4	7.0	20.9	2.1	3.6	0.4	2.3	4.6	1.6	-1.6
Neuroticism	0.6	1.5	5.9	0.2	-0.5	-0.1	-1.2	0.1	2.4	1.7
Chronotype (morning person)	0.6	1.4	4.9	1.0	1.2	-0.0	1.3	2.2	0.0	-0.6
Hair Pigment	0.0	1.2	4.9	-0.2	2.2	-0.0	1.0	1.3	-0.4	-0.5
Tanning	0.2	2.3	4.6	1.6	1.5	1.4	2.1	1.5	0.9	-1.4
Hand grip strength (left)	1.0	2.7	6.9	2.6	-0.2	-0.6	2.4	2.0	0.2	-1.3
Number of treatments/medications taken	0.5	0.8	1.4	-0.9	-1.2	-0.7	-1.1	-1.2	-0.7	0.5
Average weekly spirits intake	0.5	0.6	1.3	1.1	0.4	-0.8	1.1	-0.9	0.3	0.3
Sensitivity / hurt feelings	0.8	1.4	3.3	0.9	1.1	-1.7	-1.1	-0.4	1.8	0.6
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.7	-1.3	-1.0	1.2	-0.1	-1.2	-0.5	0.0
Hearing difficulty/problems: Yes	0.8	1.2	2.5	-0.6	-0.9	1.3	-0.5	-1.6	0.5	1.5
Relative age of first facial hair	0.2	0.4	1.2	0.4	-0.0	0.6	-0.1	0.4	1.0	1.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.2	-0.5	-1.1	1.5	0.6	0.6	0.1	0.0
Ever used hormone-replacement therapy (HRT)	1.1	1.3	4.0	-2.0	-1.7	-0.4	-0.9	-0.4	-0.1	1.1
Ever had hysterectomy (womb removed)	0.5	0.6	2.1	0.9	0.3	0.0	0.9	0.0	1.4	0.6
Systolic blood pressure, automated reading	0.5	1.4	2.7	-1.6	-1.1	-0.3	-0.9	-1.3	0.9	1.6
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	3.6	1.8	1.9	-1.9	0.2	0.6	0.1	-0.8
Angina	0.3	0.5	1.1	-1.1	-0.9	0.5	0.6	0.2	-0.1	0.8
Medication for hormone replacement therapy	0.4	0.5	1.4	-1.0	-0.9	-0.6	0.2	1.2	0.0	-0.1
Vitamin and mineral supplements	1.2	1.6	3.5	1.9	1.6	-0.2	0.6	1.6	0.4	-1.5
Supplements: Zinc	0.2	0.2	0.4	0.5	-0.2	0.6	-0.2	0.4	0.7	0.3
Medication: Co-codamol	0.4	0.5	2.6	-0.2	-0.5	-1.6	-0.4	-0.5	0.1	0.3
Medication: Metformin	0.4	0.5	2.1	0.0	1.1	-0.2	1.4	-0.6	-0.2	0.2
Diabetes (father)	0.5	0.6	2.0	0.4	-0.7	-0.6	0.0	-1.0	0.4	1.4
Diabetes (mother)	0.5	0.6	1.8	0.9	0.3	-1.3	0.6	0.8	0.5	-0.4
Severe depression (siblings)	1.6	1.8	4.8	1.4	0.7	-1.1	1.3	2.2	1.7	-0.0
Pack years adult smoking proportion	0.2	0.3	1.0	0.4	1.0	-0.2	-0.4	-0.3	0.7	0.2
Impedance of leg (right)	0.3	1.4	4.6	-2.1	-1.2	0.1	-1.7	-0.5	-0.6	-0.1
Leg fat-free mass (left)	0.6	3.2	11.0	3.3	0.7	-1.1	2.8	0.0	1.2	0.2
Trunk fat percentage	0.3	1.3	3.0	0.1	0.3	-1.7	1.4	-0.9	0.9	1.5
Hand grip strength (right)	0.2	0.5	1.5	1.2	-0.9	-0.1	0.7	0.5	-0.3	-0.2
Townsend deprivation index at recruitment	0.7	0.9	3.7	0.7	0.5	1.9	1.1	0.3	0.3	-0.8
Current tobacco smoking	2.2	3.7	6.6	2.5	1.7	-2.1	2.0	1.1	-0.2	-2.6
Average weekly fortified wine intake	0.4	0.5	2.3	-0.2	-0.2	-0.0	-0.2	-0.1	1.1	1.5
Maternal smoking around birth	0.8	1.2	3.4	1.3	1.2	-1.9	0.8	0.5	0.7	-0.6
Fed-up feelings	0.5	0.8	2.1	-0.3	-0.9	-0.4	-0.8	-1.2	0.8	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	4.2	-0.4	-0.8	1.1	-0.4	-2.1	0.5	1.6
Relative age voice broke	0.3	0.5	1.3	0.7	0.3	-0.9	0.8	0.4	1.1	0.5
Taking other prescription medications	1.7	2.5	6.6	-1.3	-1.8	-0.3	-2.0	-2.6	-1.2	1.0
Age when periods started (menarche)	1.6	3.7	7.1	2.7	2.4	-0.2	1.4	2.6	0.4	-2.1
Bilateral oophorectomy (both ovaries removed)	1.3	1.6	4.6	0.1	-0.6	0.8	-0.5	-2.1	1.3	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.7	0.2	1.1	-1.6	0.5	-0.2	-0.4	-0.5
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	4.3	-1.6	-1.1	0.9	-1.5	-2.1	-0.5	1.6
Qualifications: CSEs or equivalent	1.0	1.4	4.7	1.1	1.5	-0.5	0.6	0.4	-0.6	-2.2
Serious illness, injury or assault to yourself	1.2	1.4	5.6	-0.8	-0.9	-0.4	-2.4	-1.2	-1.1	-0.0
High blood pressure	0.4	1.0	4.2	-2.0	-0.8	0.0	0.3	0.3	-1.4	-0.2
Hayfever, allergic rhinitis or eczema	2.9	6.3	14.5	-1.7	-3.7	-0.4	-2.4	-2.0	1.7	3.8
Multivitamins +/- minerals	0.7	0.9	2.5	-1.1	-1.2	0.7	0.7	-1.6	-0.1	0.8
Stomach or abdominal pain in last month	0.6	0.8	2.2	0.7	-0.0	0.3	-0.9	-0.1	1.3	1.5
Supplements: Glucosamine	2.0	2.6	8.3	-0.7	-1.7	-0.8	-1.6	-2.9	-0.5	1.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.6	1.1	0.9	0.7	0.6	0.6	0.1	-1.3
Medication: Atenolol	0.9	1.1	3.5	0.1	1.0	0.5	1.9	1.5	0.7	0.4
Medication: Levothyroxine sodium	0.1	0.2	0.9	-0.3	-0.1	0.9	0.1	-0.5	0.3	0.1
Sitting height	0.2	1.5	3.8	1.8	0.5	-1.9	1.3	0.6	0.6	-0.7
Chronic bronchitis/emphysema (father)	1.4	1.6	3.7	1.0	0.8	-1.6	1.3	-0.2	-1.4	-1.9
High blood pressure (mother)	1.7	2.5	4.6	-1.9	-2.1	-0.4	-2.1	-0.9	-1.5	1.1
Body mass index (BMI)	0.7	2.9	6.2	1.6	0.9	-2.4	2.5	-1.2	1.4	1.3
Impedance of leg (left)	0.3	1.6	4.3	-2.1	-1.3	0.4	-2.0	-0.4	-0.7	-0.1
Leg predicted mass (left)	0.6	3.2	10.8	3.3	0.8	-1.0	2.8	-0.1	1.2	0.2
Trunk fat mass	0.5	2.0	4.5	1.1	0.3	-1.8	2.1	-0.9	1.3	1.5
Waist circumference	0.6	2.3	5.4	1.2	0.1	-1.8	2.3	-0.8	1.8	1.5
Number of incorrect matches in round	0.2	0.3	1.4	0.0	-0.1	0.7	0.4	-0.5	-0.2	-1.2
Past tobacco smoking	0.5	0.9	2.6	-1.2	0.3	1.2	-1.6	0.4	-0.3	-0.3
Alcohol usually taken with meals	0.3	0.5	3.0	0.0	-0.1	1.7	0.0	0.4	0.2	0.2
Nervous feelings	0.4	0.8	2.3	0.1	1.1	-1.5	-0.7	1.1	0.5	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.9	0.3	-0.8	-0.5	0.6	-0.2	0.9	0.7
Hearing difficulty/problems with background noise	0.6	0.9	1.7	-1.1	-0.7	-0.4	0.1	-1.3	1.1	1.3
Hair/balding pattern: Pattern 2	0.6	0.8	1.7	-1.2	0.3	-1.1	-0.3	0.1	1.3	0.9
Had menopause	0.7	0.9	2.7	-1.1	-0.8	-1.6	-0.9	-0.7	-0.5	0.7
Had other major operations	0.3	0.3	1.5	0.4	-0.6	-0.2	1.2	-0.1	0.5	0.3
Forced vital capacity (FVC)	1.3	5.1	11.0	3.1	2.6	-0.4	2.2	3.3	1.4	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.8	1.0	0.7	-1.3	-0.0	-0.2	-0.0	-0.2
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	4.9	-0.7	-2.2	0.3	-2.1	-2.2	-0.8	1.6
Qualifications: None of the above	0.3	0.6	1.9	-1.2	-0.3	0.2	0.3	-1.4	0.6	0.7
Financial difficulties in last 2 years	2.2	2.9	5.5	2.3	1.5	0.6	2.2	1.4	2.4	-0.6
Mouth/teeth dental problems	0.3	0.4	2.1	1.4	-0.2	0.1	-0.1	-0.0	-0.4	-0.9
Heart attack	0.6	0.8	3.1	0.5	-0.1	-0.4	-0.4	-0.4	-1.8	-1.2
Allergy	2.1	4.8	16.2	1.5	4.0	0.5	1.7	2.1	-1.1	-2.5
Pain all over the body in last month	1.9	2.0	4.6	-1.8	-1.9	2.1	-0.1	-0.9	-0.2	1.3
Diabetes (self-reported)	0.4	0.7	2.0	0.5	1.4	0.2	1.4	-0.6	-0.3	-0.1
Hayfever/allergic rhinitis (self-reported)	3.3	4.3	11.6	-1.4	-2.7	-0.2	-2.1	-1.3	1.8	3.4
Medication: Ramipril	0.4	0.5	2.3	-1.5	0.3	-0.5	0.2	0.2	-0.7	-0.4
Medication: Simvastatin	0.6	0.9	2.9	-1.0	-0.5	1.7	1.1	1.0	-0.0	0.3
Fluid intelligence score	0.1	0.3	1.1	-0.4	0.5	0.1	0.2	1.0	-0.6	-0.1
Illnesses of siblings	0.4	0.5	1.2	0.6	0.4	0.5	0.3	0.9	-0.7	-1.1
Neuroticism score	0.4	0.9	3.8	0.4	0.1	0.2	-1.0	-0.0	1.9	1.2
Weight	0.8	3.8	8.9	2.7	0.5	-2.3	3.0	-0.8	1.7	1.1
Impedance of arm (right)	1.0	4.9	12.2	-3.4	-2.3	0.9	-3.5	-0.1	-2.0	-0.5
Arm fat percentage (right)	0.5	1.8	5.7	-0.1	-0.3	-2.4	1.0	-1.3	0.9	1.9
Trunk fat-free mass	0.8	4.5	15.4	3.9	0.8	-1.5	3.1	-0.0	1.8	0.4
Hip circumference	0.8	3.3	8.0	2.2	0.5	-1.9	2.8	-0.7	1.9	1.6
Time employed in main current job	0.6	0.7	1.8	-0.8	0.1	-1.0	-1.3	-0.7	-1.0	-0.5
Alcohol intake versus 10 years previously	0.3	0.4	1.6	0.6	0.4	-0.5	1.3	0.1	0.3	-0.3
Father’s age at death	0.7	1.0	4.0	0.0	0.7	2.0	0.4	-0.1	1.0	1.1
Worrier / anxious feelings	0.1	0.2	0.7	0.3	-0.2	-0.3	-0.3	-0.7	0.8	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.1	-0.6	-0.0	-1.5	-1.2	-1.8	0.0	0.1
Falls in the last year	0.6	0.8	3.1	1.7	0.6	-0.2	-1.1	-0.2	0.1	-1.0
Hair/balding pattern: Pattern 3	0.1	0.1	0.6	0.2	0.3	-0.2	-0.2	-0.2	0.4	0.8
Number of live births	0.7	1.0	5.6	-0.6	-0.2	-2.4	0.4	0.2	0.0	-0.6
Forced expiratory volume in 1-second (FEV1)	2.1	7.0	14.4	3.8	3.1	-1.2	2.4	3.8	1.2	-1.6
Pulse rate	0.3	0.5	1.5	0.4	0.4	-0.4	0.8	0.2	1.2	0.7
Happiness	1.3	1.6	4.5	1.3	-0.4	0.4	0.7	1.9	2.1	0.7
Noisy workplace	1.4	1.7	4.5	-1.2	-1.5	-0.1	-0.9	-2.1	-0.1	1.7
Qualifications: A levels/AS levels or equivalent	0.7	1.6	5.9	-1.0	-0.5	1.5	0.2	0.2	1.4	2.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.5	-0.1	-0.2	-0.2	0.7	-0.1	0.2	-0.1
Mouth/teeth dental problems: Dentures	0.3	0.6	3.1	-0.5	0.1	0.3	0.1	-0.4	-1.7	-0.6
Asthma	1.7	3.3	9.7	-1.5	-3.1	0.2	-1.4	-2.7	0.2	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	4.1	1.2	2.0	-0.8	0.8	1.1	0.7	-0.5
Medication: Cholesterol lowering	0.6	0.9	3.9	-1.4	0.0	2.0	0.3	0.1	-0.7	0.2
Depression (self-reported)	0.1	0.2	0.5	-0.2	-0.7	-0.7	0.4	0.1	0.2	0.1
Medication: Lansoprazole	0.6	0.7	2.2	0.6	0.2	-0.6	1.1	0.2	1.5	0.8
Prospective memory result	0.6	0.8	2.6	-0.1	0.5	0.7	0.7	0.5	-1.1	-1.6
Lung cancer (father)	1.2	1.4	3.2	0.5	1.7	-0.7	1.1	0.8	-1.0	-1.8
Illnesses of mother	4.5	5.6	14.1	3.8	3.1	-0.8	2.8	1.2	1.3	-2.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.0	16.9	4.1	2.1	-0.2	2.3	3.1	0.7	-2.3
Pulse wave Arterial Stiffness index	4.1	4.7	12.9	3.6	1.6	-3.0	1.8	1.6	0.4	-1.7
Impedance of arm (left)	0.8	3.9	9.4	-3.1	-1.9	1.6	-2.9	0.4	-1.6	-0.2
Arm fat mass (right)	0.6	2.5	6.3	1.3	0.4	-2.5	2.2	-1.1	1.3	1.4
Trunk predicted mass	0.8	4.5	15.1	3.9	0.8	-1.5	3.2	0.1	1.9	0.4
Standing height	0.2	1.5	7.2	2.7	-0.9	-0.2	1.4	0.3	0.7	-0.2
Length of working week for main job	3.4	3.7	7.0	2.6	2.0	0.1	2.5	2.2	1.3	-1.6
Exposure to tobacco smoke at home	1.5	1.7	3.6	1.2	1.3	0.7	1.9	0.9	-1.0	-1.7
Breastfed as a baby	0.3	0.4	0.8	0.3	0.9	0.2	0.9	0.9	-0.2	-0.6
Tense / ‘highly strung’	0.4	0.6	1.4	0.4	-0.9	1.2	-0.7	0.6	-0.6	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.0	0.3	-0.7	-0.3	0.3	0.2	1.0	0.8
Hair/balding pattern: Pattern 4	0.7	1.7	5.1	1.1	2.2	0.1	0.6	0.9	-0.2	-2.0
Birth weight of first child	0.2	0.3	1.2	0.0	-0.2	0.3	-0.2	-0.9	0.2	1.1
Peak expiratory flow (PEF)	0.3	0.6	2.6	1.0	0.1	-1.6	0.7	-0.1	-0.6	-0.2
Pulse wave reflection index	1.1	1.4	5.8	2.4	0.6	-0.8	0.7	0.9	0.5	-1.1
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.1	1.0	-0.4	-0.3	-0.4	-0.5	-0.7	-0.1
Loud music exposure frequency	0.9	1.0	2.9	1.3	0.9	0.7	1.7	0.8	-0.4	-0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.6	-0.4	-0.8	-1.3	-1.1	-0.0	0.2	1.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.4	-0.5	-0.5	-0.7	0.7	0.6	1.8	0.9
Blood clot in the leg (DVT)	1.2	1.6	5.9	0.5	-0.2	-0.3	-0.2	-0.1	-2.2	-2.4
Medication: Paracetamol	0.3	0.4	1.2	-0.1	-1.0	-0.4	-0.7	-1.1	-0.1	0.1
Headache pain in last month	0.4	0.6	0.9	-0.2	-0.9	-0.9	-0.9	0.0	0.9	1.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.3	1.5	-0.4	-0.7	-0.5	-0.1	1.2	0.5
Glaucoma (self-reported)	0.9	1.0	2.9	1.3	0.8	0.5	1.1	0.7	-0.1	-1.7
Gout (self-reported)	0.3	0.5	1.3	-0.9	-0.3	0.9	1.1	-0.3	0.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.9	-1.0	-0.9	0.7	-0.2	-0.7	-0.1	0.4
Medication: Amlodipine	0.6	0.8	1.6	-1.0	1.0	0.1	0.4	1.0	-1.3	-0.7
Medication: Ventolin 100micrograms inhaler	1.4	1.8	5.1	-1.6	-1.9	-0.0	-0.7	-0.9	0.6	2.3
Birth weight	0.1	0.3	1.0	-0.2	0.1	0.2	0.4	-0.9	0.4	1.0
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.5	-1.6	-0.6	1.4	-0.4	-0.4	0.4	1.2
High blood pressure (siblings)	0.1	0.2	0.8	-0.5	0.0	0.0	-0.4	-0.4	0.0	0.9
Forced vital capacity (FVC), Best measure	1.1	4.1	11.8	3.4	1.4	0.3	1.9	2.8	0.8	-1.8
Body fat percentage	0.5	1.8	4.1	0.2	0.4	-2.0	1.7	-0.9	1.3	1.7
Leg fat percentage (right)	0.7	2.6	5.7	0.5	0.5	-2.0	2.4	-0.9	1.9	1.8
Arm fat-free mass (right)	1.1	5.7	17.6	4.2	1.4	-1.3	3.9	0.1	2.0	0.3
Exposure to tobacco smoke outside home	0.9	1.3	4.3	-0.1	1.5	-0.9	2.1	0.7	1.0	0.2
Comparative body size at age 10	0.1	0.3	0.8	-0.6	0.5	0.5	0.4	-0.3	-0.9	-0.4
Number of full brothers	1.9	2.4	6.9	1.6	1.1	-0.9	2.6	1.7	1.5	-0.5
Worry too long after embarrassment	0.3	0.5	2.1	0.4	0.7	0.1	-1.4	0.5	0.1	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	9.1	-0.9	-3.0	0.5	-2.2	-2.2	-0.6	1.2
Wheeze or whistling in the chest in last year	1.0	1.8	4.7	0.7	-1.4	0.9	0.5	-0.6	2.1	2.2
Number of children fathered	1.5	1.7	5.4	0.2	-0.8	-1.3	-0.6	-1.3	1.4	2.3
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	5.7	1.1	0.6	1.0	1.7	1.6	-0.0	-2.4
Age at first live birth	0.1	0.2	0.7	-0.1	-0.6	-0.0	-0.8	-0.3	-0.3	0.4
Pulse wave peak to peak time	3.5	4.1	10.8	-3.3	-1.5	2.8	-1.7	-1.5	-0.4	1.6
Health satisfaction	0.5	0.6	1.9	0.9	-0.3	-1.2	-0.2	-0.2	1.4	0.5
Shortness of breath walking on level ground	0.4	0.4	1.6	1.3	-0.1	0.0	1.1	-0.1	0.6	0.1
Qualifications: College or University degree	0.3	0.8	3.3	-0.7	-0.9	1.8	-0.2	1.0	0.0	0.0
Eye problems/disorders: None of the above	0.2	0.3	0.8	-0.9	-0.4	0.2	0.6	0.4	-0.7	-0.3
Mouth/teeth dental problems: Loose teeth	0.7	0.9	3.2	-1.1	-0.3	1.8	0.1	-0.1	-1.1	0.6
Emphysema/chronic bronchitis	1.3	1.4	4.4	1.0	0.4	-0.9	2.1	1.2	0.3	-1.4
Medication for pain relief, constipation, heartburn	1.1	1.8	2.9	1.4	1.2	1.2	1.6	1.7	1.5	-0.4
Neck or shoulder pain in last month	0.4	0.6	1.3	-0.0	-0.8	-1.0	0.2	-1.2	-1.0	-0.7
Medication: Blood pressure	0.7	1.3	3.9	-0.9	0.9	-0.0	0.7	0.3	-2.0	-1.7
Angina (self-reported)	0.2	0.3	0.7	-0.8	-0.6	0.4	0.6	0.4	-0.3	0.5
Migraine (self-reported)	0.3	0.4	1.7	0.3	0.1	-1.3	-0.5	-0.8	-0.0	0.0
Medication: Ibuprofen	0.9	1.1	3.9	1.2	2.0	-1.2	0.5	0.5	0.4	-0.4
Medication: Allopurinol	0.3	0.4	1.4	-1.2	-0.3	-0.6	0.8	-0.1	0.1	0.5
Medication: Omeprazole	0.3	0.4	1.2	0.2	-0.6	-1.1	0.4	-0.9	0.0	0.5
Medication: Seretide 50 evohaler	2.1	2.4	5.2	-1.4	-1.6	0.4	-1.8	-1.7	0.8	2.3
Mean time to correctly identify matches	0.9	1.7	4.1	-2.0	-1.8	1.1	0.2	-1.1	-1.5	-0.4
Heart disease (mother)	0.7	0.8	3.4	-1.9	-0.7	-0.2	-1.1	-0.3	-0.2	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	4.6	0.7	1.4	0.0	2.1	1.5	0.4	-1.1
Whole body fat mass	0.6	2.4	4.5	1.3	0.4	-2.0	2.1	-1.0	1.6	1.7
Leg fat mass (right)	0.8	3.0	7.6	1.4	0.3	-2.0	2.8	-1.1	1.8	1.7
Arm predicted mass (right)	1.0	5.3	16.5	4.1	1.4	-1.2	3.7	-0.0	1.8	0.3
Pulse rate, automated reading	0.1	0.4	1.0	0.1	-0.7	0.2	-0.1	-0.2	0.9	1.0
Alcohol intake frequency.	0.9	2.1	5.5	-1.1	-1.5	0.7	-1.0	-1.4	1.5	2.4
Comparative height size at age 10	0.1	0.7	1.2	1.1	-1.0	-0.5	0.6	-0.6	0.8	1.1
Number of full sisters	0.8	1.0	2.9	0.9	0.6	-1.6	0.2	-0.1	-0.7	-1.7
Suffer from ‘nerves’	0.2	0.4	1.0	-0.4	-0.8	-0.7	-0.5	1.0	0.1	-0.4
Overall health rating	0.6	1.3	2.8	-1.0	-0.8	-1.1	-0.8	-0.9	1.4	1.7
Chest pain or discomfort	1.3	1.9	6.8	-0.3	-1.0	-0.2	-0.1	-0.6	2.6	2.3
Had major operations	1.7	2.0	5.9	-0.8	-2.4	-0.7	-1.2	-1.9	-1.4	-0.2
Age at last live birth	0.2	0.2	0.6	0.1	-0.6	-0.7	0.0	0.1	0.3	0.8
Family relationship satisfaction	3.5	4.2	9.6	2.2	1.3	0.9	2.8	3.1	2.0	-0.9
Leg pain on walking	0.5	0.6	1.8	0.9	-0.5	0.7	-0.0	-1.4	-0.6	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.7	1.3	0.7	-0.6	0.2	0.5	-1.1	-1.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.3	0.9	-1.0	-1.0	-1.1	-0.9	0.3	1.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.9	-0.2	-0.5	-0.6	-0.5	-0.3	-1.4	-0.4
Medication: Aspirin	0.4	0.5	1.4	-0.9	-0.7	0.2	-0.7	-0.7	-1.2	-0.1
Supplements: Vitamin C	0.7	0.8	3.6	-0.9	-0.4	-0.1	0.0	0.2	1.0	1.9
Knee pain experienced in last month	0.2	0.3	1.5	0.6	0.3	-0.1	0.2	-1.2	0.2	0.4
Hypertension (Self-reported)	0.6	1.5	5.0	-2.2	-1.1	0.4	-0.0	0.0	-2.0	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.4	9.9	-0.3	-0.6	-3.1	-1.4	-1.4	0.4	1.5
Illnesses of father: Heart disease	0.7	0.9	3.0	-0.7	-0.6	-0.1	-1.4	-1.7	-0.7	0.4
Illnesses of siblings: Diabetes	0.7	0.8	3.0	0.8	1.0	-0.6	1.7	-0.0	0.7	-0.5
Smoking status: Previous	0.3	0.4	1.3	1.1	-0.1	-0.4	1.0	-0.3	0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	6.4	2.5	0.9	0.3	2.2	1.4	0.5	-1.6
Whole body fat-free mass	0.7	4.3	14.3	3.8	1.0	-1.3	3.2	0.1	1.6	0.3
Leg fat-free mass (right)	0.5	2.9	11.4	3.4	0.6	-0.6	2.7	0.2	1.1	0.0
Arm fat percentage (left)	0.4	1.7	4.0	0.3	0.2	-2.0	1.5	-0.8	1.2	1.9
Average weekly red wine intake	0.4	0.7	2.4	1.0	0.1	1.5	-0.1	-0.6	0.6	0.6
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.8	-0.3	-0.0	-0.0	0.4	0.4	-0.9	-0.5
Mood swings	0.9	1.7	4.1	-0.8	-1.5	0.9	-1.0	-2.0	0.5	1.6
Loneliness, isolation	0.4	0.6	2.7	0.7	0.5	0.0	0.2	0.6	1.6	0.5
Long-standing illness, disability or infirmity	0.2	0.3	0.8	-0.0	-0.6	0.4	0.2	0.8	0.9	0.5
Ever had bowel cancer screening	0.9	1.1	6.3	-0.2	0.1	-0.2	-2.5	-0.6	-0.9	-0.3
Diabetes diagnosed by doctor	0.2	0.3	1.0	-0.4	0.6	0.0	0.6	-1.0	-0.5	0.5
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.5	4.3	2.0	2.1	-1.4	1.1	1.7	1.0	-1.5
Friendships satisfaction	0.8	0.9	2.4	0.9	-0.1	1.4	0.1	1.5	0.5	-1.1
Qualifications: nursing, teaching	0.2	0.3	1.5	0.2	-0.5	1.2	0.5	0.5	-0.4	-0.2
Commuting to job workplace: Walk	0.7	0.7	1.6	-0.0	1.1	0.8	0.8	1.2	-0.3	-1.0
Eye problems/disorders: Cataract	0.5	0.6	1.3	0.6	1.1	0.8	-0.2	0.9	0.9	0.1
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	7.4	0.7	2.0	0.7	2.1	2.7	0.5	-1.2
Medication for cholesterol	1.5	2.3	7.2	2.7	2.5	0.1	1.4	-0.0	0.9	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	3.0	-1.7	-1.1	-0.7	-1.5	-1.4	-1.6	-0.3
Back pain experienced in last month	0.3	0.4	2.8	-0.3	-0.2	-1.7	-0.4	-0.0	-0.2	0.1
Mineral and other dietary supplements	0.8	1.0	4.7	1.3	0.4	-0.2	0.1	2.2	0.7	-0.5
Breast cancer (self-reported)	0.5	0.6	2.3	-0.4	-0.5	0.0	-0.4	-0.8	-1.5	-0.8
Asthma (self-reported)	1.4	2.8	8.9	-1.2	-3.0	-0.3	-1.4	-2.3	0.3	1.3
Osteoporosis (self-reported)	0.1	0.1	0.5	-0.7	-0.1	-0.1	0.1	0.2	-0.3	-0.4
Osteoarthritis (self-reported)	1.3	1.7	3.4	-1.3	-1.8	-0.1	-1.0	-1.8	-1.5	0.7
Medication: Aspirin	0.9	1.1	2.6	-1.3	-1.1	-0.4	-0.9	-1.1	-1.6	0.0
Medication: Gliclazide	0.7	0.7	1.3	-0.6	0.1	1.0	1.1	-0.4	-1.1	-1.0
Illnesses of father: None of the above (group 1)	0.5	0.6	1.7	0.8	0.2	0.3	0.9	1.3	0.9	-0.4
Smoking status: Current	2.4	3.9	6.5	2.4	1.7	-2.6	2.4	1.1	0.1	-2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.4	15.7	2.1	1.8	-0.2	2.1	4.0	1.3	-1.0
Whole body water mass	0.7	4.2	14.3	3.8	0.9	-1.2	3.3	-0.0	1.5	0.3
Leg predicted mass (right)	0.6	2.9	11.2	3.4	0.6	-0.6	2.7	0.2	1.1	0.1
Arm fat mass (left)	0.7	2.7	5.6	1.3	0.4	-2.4	2.2	-1.0	1.6	1.8
Number of self-reported non-cancer illnesses	2.6	4.6	10.2	-3.2	-3.1	-0.2	-1.8	-2.0	-1.9	1.1
Average weekly champagne plus white wine intake	0.3	0.5	2.3	-0.4	-0.3	1.5	-0.1	-0.1	-0.2	0.7
Miserableness	1.4	2.4	7.5	-1.7	-1.1	0.1	-0.7	-1.9	1.2	2.7
Guilty feelings	0.3	0.5	1.9	0.2	0.5	0.5	-0.4	0.5	1.4	0.8
Wears glasses or contact lenses	1.0	1.1	5.8	-0.2	-0.7	2.4	0.9	-0.8	-0.4	-0.1
Ever taken oral contraceptive pill	1.4	1.6	4.0	-1.2	1.3	0.1	1.0	0.2	1.6	2.0
Hearing aid user	2.1	2.3	7.5	-1.4	-1.7	-0.8	-0.5	-1.2	1.3	2.7
Mother’s age at death	1.3	1.6	4.3	-0.7	-1.9	0.1	-1.0	-0.6	1.2	2.1
Financial situation satisfaction	2.7	3.3	8.3	2.9	1.2	-1.1	2.2	1.8	1.5	-1.3
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.5	-0.9	-1.6	0.5	-0.9	-1.1	0.8	1.9
Commuting to job workplace: Public transport	1.2	1.4	3.5	-1.1	-1.0	1.8	0.0	-0.9	0.6	1.9
Eye problems/disorders: Glaucoma	0.2	0.2	0.9	1.0	-0.1	-0.3	0.2	0.4	0.6	-0.4
Medication: Blood pressure	0.6	1.2	3.8	-1.9	-1.2	0.2	-1.4	-0.0	-1.2	0.1
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.7	0.5	0.4	-1.1	0.8	-0.7	-0.9	-1.3
Supplements: Fish oil (including cod liver oil)	0.7	0.9	4.3	-1.0	0.1	0.1	0.6	-2.1	0.1	0.6
High cholesterol (Self-reported)	1.4	2.4	7.9	-2.8	-0.8	2.2	-0.9	0.1	-1.6	0.5
Medication: Bendroflumethiazide	0.8	1.2	5.2	-1.2	-0.8	-0.3	-0.6	-0.3	-2.3	-0.8
Medication: Paracetamol	0.6	0.9	2.9	-0.5	-1.1	-0.6	-1.0	-1.7	-0.9	-0.1
Medication: Lisinopril	0.7	0.9	2.3	-0.2	-0.9	-1.5	-0.3	0.3	-1.5	-0.7
Medication: Atorvastatin	0.8	1.0	3.0	-0.8	-0.8	0.4	-1.7	-1.1	-1.1	0.4
Illnesses of father: High blood pressure	0.6	0.7	1.4	0.2	0.1	1.1	1.1	-0.2	-1.0	-1.2
Alcohol drinker status: Never	1.2	1.5	3.4	-1.7	-0.8	-0.0	-1.4	-1.0	-1.8	0.3
Ever smoked	0.4	0.7	2.2	1.1	-0.5	-1.0	1.5	-0.5	-0.2	-0.2
Basal metabolic rate	0.7	4.0	12.2	3.5	0.7	-1.6	3.1	-0.2	1.6	0.5
Leg fat percentage (left)	0.6	2.1	3.9	0.6	0.4	-1.7	2.0	-1.0	1.7	1.8
Arm fat-free mass (left)	0.8	4.1	11.9	3.5	0.7	-2.0	3.0	-0.7	1.7	0.6
Number of operations (self-reported)	1.0	1.5	4.2	-0.4	-2.1	-0.6	-1.4	-1.7	-1.0	0.2
Average weekly beer plus cider intake	1.0	1.5	3.5	1.1	1.4	-1.9	1.6	0.8	0.2	-0.8
Irritability	0.9	1.4	2.7	0.4	-1.1	1.6	-1.5	-1.4	-1.2	-0.6
Risk taking	0.3	0.5	1.8	1.3	-0.3	-0.8	-0.3	-0.7	-0.3	0.7
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.4	-0.3	0.2	-0.1	0.1	-0.4	-1.2	-0.8
Fractured/broken bones in last 5 years	1.1	1.4	4.2	-0.1	-2.0	1.8	-0.5	-1.1	-0.9	-0.6
Age started oral contraceptive pill	0.5	0.6	2.1	-1.4	-0.6	-0.5	-0.7	0.5	-0.7	-0.3
Diastolic blood pressure, automated reading	0.3	1.0	3.1	1.1	0.5	-0.5	1.2	0.2	1.8	1.0
Ever depressed for a whole week	0.6	0.8	2.2	0.1	-1.5	-0.4	-0.9	-0.4	0.6	1.3
Unable to work because of sickness or disability	0.5	0.7	1.6	0.2	1.3	1.3	0.9	-0.9	0.0	-0.0
Commuting to job workplace: Cycle	0.4	0.5	1.7	0.0	-0.5	0.4	-0.0	-0.8	0.8	1.3
Myopia	0.8	1.1	4.0	-1.6	0.9	2.0	0.4	0.6	-0.0	0.0
Vascular/heart problems diagnosed by doctor	0.4	1.2	4.1	2.0	0.8	0.1	-0.2	-0.3	1.8	0.3
Cholesterol lowering medication	0.8	1.2	3.9	-1.4	-2.0	0.1	-1.3	-0.4	-0.7	0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.7	-0.3	-0.3	-1.3	0.1	-1.2	0.1	0.8
Pain experienced in last month	0.6	0.9	2.2	1.2	1.5	0.8	0.8	0.5	0.6	-0.9
Supplements: Calcium	0.4	0.5	2.6	-1.6	-0.2	-0.4	-0.3	-0.4	-0.4	0.2
Basal cell carcinoma (self-reported)	0.5	0.6	1.8	0.1	0.5	0.1	0.8	-0.9	-1.4	-0.8
Heart attack/myocardial infarction (self-reported)	0.6	0.8	3.3	0.3	-0.3	-0.5	-0.2	-0.3	-1.8	-1.2
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	5.0	0.3	-0.4	-0.2	-0.5	-0.4	-2.2	-2.2
Heart disease (siblings)	0.3	0.4	1.8	0.0	-1.3	-0.4	0.0	-0.6	-0.5	-0.6
Alcohol drinker status: Previous	2.1	2.4	6.2	-0.0	-1.6	1.8	1.1	-0.4	1.8	2.5
Pack years of smoking	0.2	0.3	0.8	0.1	0.9	-0.3	-0.4	-0.4	0.8	0.5
Impedance of whole body	0.6	2.9	8.0	-2.8	-1.5	0.9	-2.8	0.1	-1.1	-0.0
Leg fat mass (left)	0.7	2.7	6.0	1.3	0.2	-2.0	2.4	-1.2	1.6	1.7
Arm predicted mass (left)	0.9	4.5	12.7	3.6	1.1	-2.0	3.3	-0.5	1.7	0.3