Hub : Genes

IL7R

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1370	0.0570	6.4e-03	0.002	NA	0.021	NA	0.009	2.0e-01	NA	1.0e-02	NA	6.6e-02
2	GTEx	Testis	0.2460	0.0700	1.3e-05	0.190	NA	0.131	NA	0.180	8.0e-09	NA	2.1e-06	NA	2.1e-08
3	YFS	Blood	0.0292	0.0117	4.0e-04	0.011	0.009	0.010	0.011	0.010	8.3e-05	0.00055	2.4e-04	8.1e-05	1.7e-04
4	TCGA	Lung Squamous Cell Carcinoma	0.0402	0.0194	1.5e-04	0.031	0.023	0.018	NA	0.023	1.6e-04	0.00110	3.6e-03	NA	9.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.1	2.9	-1.7	0.7	-0.2	-0.9
Bipolar Disorder or Schizophrenia	0.2	0.5	1.3	-0.7	-0.1	-0.3	-1.2
Depressed Affect (Nagel 2018)	0.1	0.3	0.6	-0.8	-0.7	0.1	-0.2
Depression (Nagel 2018)	0.6	0.9	1.5	1.2	-1.1	-1.1	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.7	0.2	0.5	0.8	-0.5
Neuroticism (Nagel 2018)	0.8	1.8	3.9	-1.1	-2.0	-1.0	1.0
Schizophrenia (2018)	0.1	0.3	0.6	0.3	-0.6	-0.2	-0.8
Schizophrenia vs Biploar Disorder	0.5	0.7	1.6	1.3	-0.1	1.1	0.1
Worry (Nagel 2018)	0.2	0.4	0.9	-0.9	-0.9	-0.1	0.3
Alzheimer’s Disease (in mother)	1.4	1.6	4.3	-0.7	2.1	1.1	0.7
Alzheimer’s Disease (in father)	0.6	0.7	1.2	0.5	0.5	-1.1	-1.0
Alzheimer’s Disease (including proxy)	0.8	1.2	4.4	-0.6	2.1	0.3	0.2
Crohns Disease (2017)	0.9	2.0	5.3	-0.3	0.6	1.5	-2.3
Irritable Bowel Disease (IBD)	0.9	2.1	6.5	1.3	0.5	-0.5	-2.5
Ulcerative Colitis (UC)	1.2	2.2	3.6	1.9	-0.4	-1.8	-1.3
Major Depression (MDD)	0.4	0.5	1.0	-1.0	-0.1	1.0	0.0
Reaction Time	0.3	0.5	1.2	-0.7	0.6	1.1	0.3
Verbal and Numeric Reasoning (VNR)	0.4	0.8	1.5	1.2	0.8	0.9	-0.6
Breast Cancer	1.2	2.9	6.4	0.7	2.5	1.9	-1.0
Ovarian Cancer	1.6	2.1	5.4	-1.1	-1.4	2.3	0.1
Prostate Cancer	0.8	1.2	3.5	-0.0	0.9	-0.6	-1.9
Age at First Birth	0.4	0.5	1.1	1.1	-0.7	0.3	-0.7
Bipolar Disorder (2011)	1.2	1.2	2.0	1.2	-1.1	-0.2	-1.4
Body Mass Index (BMI) (2010)	0.8	1.1	3.7	1.9	0.4	0.7	0.1
Coronary Artery Disease (CAD)	0.1	0.1	0.2	-0.4	-0.5	0.3	-0.3
Crohns Disease (2012)	0.3	0.5	1.1	-0.7	-1.1	0.3	-0.4
Mean Putamen Volume	0.7	0.8	1.6	0.8	1.3	1.0	0.1
Fasting Glucose	2.2	2.7	5.2	-1.0	-0.7	2.3	-2.0
HbA1C	0.4	0.4	1.4	1.2	0.1	-0.4	-0.4
HDL Cholesterol	0.3	0.6	1.2	-0.6	-0.8	-1.1	0.3
LDL Cholesterol	1.5	2.4	5.9	-0.2	-2.4	-0.7	1.8
Lupus	1.8	2.7	4.4	0.5	1.4	2.1	-2.1
Neuroticism (2016)	0.6	0.9	2.0	-0.2	-0.8	-1.4	1.0
Primary Biliary Cirrhosis	10.4	14.8	34.3	-0.0	3.4	3.7	-5.9
Rheumatoid Arthritis	0.7	0.9	3.4	0.4	0.2	-0.1	-1.8
Schizophrenia (2014)	0.1	0.1	0.3	-0.6	0.3	-0.2	0.0
Triglycerides	0.8	1.4	2.8	1.7	-0.7	0.9	1.2
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.4	0.3	0.0	0.5	-1.2
Ulcerative Colitis	1.0	1.5	2.0	1.1	-1.4	-1.2	-1.2
Blood Eosinophil Count	9.9	76.6	237.2	1.9	3.9	7.1	-15.4
Blood Platelet Count	0.2	2.2	5.6	-0.4	-2.4	-0.9	1.4
Blood Red Count	0.2	2.0	3.5	1.0	1.9	-1.8	0.2
Blood White Count	0.9	6.6	15.5	-1.0	-2.9	-1.2	-3.9
Heel T-Score	0.2	1.2	3.9	0.9	2.0	0.3	0.4
BMI	0.2	1.2	3.5	0.5	0.4	1.9	1.0
Height	0.8	15.2	38.9	-1.2	-2.4	-6.2	3.8
Waist Hip Ratio (WHR)	0.1	0.3	0.6	-0.1	0.7	-0.8	0.0
Systolic Blood Pressure	0.2	0.8	1.7	-1.3	-1.0	-0.7	0.5
Smoking Status	0.4	1.0	1.4	-0.8	-0.9	-1.1	1.2
Allergy or Eczema	31.7	83.4	240.2	0.5	7.3	6.3	-15.5
Cardiovascular Disease	1.5	4.9	7.7	-0.9	-2.0	-2.8	2.6
Hypothyroidism (self reported)	4.8	11.1	26.6	0.5	-1.0	4.1	-5.2
Respiratory disease	6.6	14.6	35.8	0.3	1.4	4.5	-6.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.1	-0.5	-0.5	-0.3	1.1
Lung FEV1/FVC ratio	1.6	8.2	26.7	0.5	-1.8	-1.6	5.2
Lung FVC	0.1	0.5	1.6	0.2	-1.3	-0.5	0.2
Neuroticism	0.3	0.8	1.8	-0.0	-1.1	-1.3	-0.3
Chronotype (morning person)	0.8	2.0	3.3	-1.1	1.8	1.7	0.7
Hair Pigment	0.1	1.7	3.2	-0.2	-1.5	-1.8	-1.1
Tanning	0.2	2.9	6.8	-0.5	-1.8	-1.1	2.6
Hand grip strength (left)	0.4	1.0	2.0	-0.3	1.4	-1.4	0.1
Number of treatments/medications taken	0.7	1.2	3.7	-0.3	-1.9	0.8	-0.7
Average weekly spirits intake	0.1	0.2	0.6	0.0	-0.8	0.0	0.2
Sensitivity / hurt feelings	0.5	0.9	1.5	1.2	0.8	-1.0	0.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	0.5	-0.5	-0.5	-0.6
Hearing difficulty/problems: Yes	0.5	0.8	2.0	0.9	-0.6	0.1	-1.4
Relative age of first facial hair	0.6	1.3	2.3	0.4	1.3	1.1	-1.5
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	3.3	1.6	-1.8	1.6	-0.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	0.0	-0.5	-0.9	-0.6
Ever had hysterectomy (womb removed)	2.7	3.0	11.1	0.8	-0.2	-3.3	0.5
Systolic blood pressure, automated reading	0.2	0.5	1.1	0.1	-1.1	-0.9	0.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.6	0.1	-0.5	-0.5	1.3
Angina	1.0	1.3	3.6	0.9	-1.9	-0.5	0.8
Medication for hormone replacement therapy	1.0	1.2	1.8	-1.2	0.6	-1.4	1.0
Vitamin and mineral supplements	0.6	0.8	2.1	0.9	0.0	1.4	-0.3
Supplements: Zinc	0.5	0.5	0.9	0.5	-0.8	-1.0	0.5
Medication: Co-codamol	1.0	1.2	1.4	1.1	0.9	1.2	-1.1
Medication: Metformin	1.0	1.4	3.0	1.4	-0.3	0.8	1.7
Diabetes (father)	1.3	1.6	4.2	2.0	1.3	-0.5	0.4
Diabetes (mother)	0.3	0.4	1.1	0.6	-1.1	-0.2	-0.3
Severe depression (siblings)	1.0	1.2	4.0	0.6	2.0	0.1	-0.5
Pack years adult smoking proportion	0.6	0.9	2.4	-0.3	-0.6	1.5	-0.8
Impedance of leg (right)	0.7	3.3	5.3	-2.3	-0.1	1.7	-2.2
Leg fat-free mass (left)	0.3	1.3	3.9	-0.7	-0.0	-1.0	2.0
Trunk fat percentage	0.3	1.2	3.1	1.2	-0.1	1.8	0.1
Hand grip strength (right)	0.3	0.8	1.3	-1.1	0.9	-0.9	-0.6
Townsend deprivation index at recruitment	0.5	0.7	1.4	-0.5	0.7	0.8	-1.2
Current tobacco smoking	0.6	1.1	3.5	-1.9	-0.7	-0.4	0.2
Average weekly fortified wine intake	0.4	0.4	0.9	0.8	-0.3	-1.0	0.0
Maternal smoking around birth	0.3	0.4	0.6	0.8	-0.7	0.6	-0.3
Fed-up feelings	0.3	0.5	1.4	-0.2	1.2	-0.1	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.7	1.3	0.2	0.1	-1.1
Relative age voice broke	0.5	0.7	1.5	-0.8	-0.1	-0.8	-1.2
Taking other prescription medications	2.7	4.1	9.5	0.3	-0.5	3.1	-2.6
Age when periods started (menarche)	0.4	1.0	3.6	-0.5	-0.2	-0.4	-1.9
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.3	0.1	-0.4	-1.8	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	4.6	-0.7	2.2	0.7	-0.7
Tinnitus: Yes, but not now, but have in the past	1.8	2.0	4.2	-0.1	-0.3	2.0	-1.9
Qualifications: CSEs or equivalent	0.3	0.4	0.8	-0.8	0.9	-0.4	0.1
Serious illness, injury or assault to yourself	0.5	0.7	1.6	-0.1	-1.3	0.1	1.0
High blood pressure	1.5	4.1	8.4	0.0	-2.2	-2.9	1.8
Hayfever, allergic rhinitis or eczema	30.1	65.2	182.2	-0.1	6.8	5.7	-13.5
Multivitamins +/- minerals	0.3	0.4	1.1	-0.3	0.2	-1.1	0.4
Stomach or abdominal pain in last month	0.0	0.0	0.0	0.1	0.2	-0.1	0.1
Supplements: Glucosamine	1.8	2.4	4.1	2.0	-1.6	-1.6	0.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	-0.9	0.9	-0.5	0.6
Medication: Atenolol	1.1	1.3	4.9	0.2	0.5	-0.3	2.2
Medication: Levothyroxine sodium	5.1	8.7	17.6	-0.7	-0.1	4.1	-4.2
Sitting height	0.5	3.4	5.9	-1.8	-0.9	-2.4	1.9
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	0.2	-0.5	0.6	-0.3
High blood pressure (mother)	0.4	0.6	2.1	0.3	-0.3	-1.5	0.4
Body mass index (BMI)	0.5	2.0	3.2	1.7	0.6	1.8	1.2
Impedance of leg (left)	0.5	2.4	4.2	-2.0	0.1	1.2	-1.9
Leg predicted mass (left)	0.2	1.3	3.7	-0.7	-0.1	-1.0	1.9
Trunk fat mass	0.1	0.6	0.8	0.9	-0.1	0.9	0.9
Waist circumference	0.2	0.8	1.7	0.6	0.2	1.0	1.3
Number of incorrect matches in round	0.3	0.5	1.6	0.1	-0.4	-1.3	-0.2
Past tobacco smoking	0.5	0.8	2.9	0.5	1.7	-0.0	-0.4
Alcohol usually taken with meals	1.2	2.0	4.1	0.3	-2.0	-0.4	1.9
Nervous feelings	0.7	1.3	2.5	0.7	-1.6	-1.3	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.0	0.7	-0.8	0.1	-1.4
Hearing difficulty/problems with background noise	0.4	0.7	1.6	0.8	-1.2	-0.4	-0.5
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	1.1	-0.1	-0.8	-0.1
Had menopause	0.6	0.8	0.9	1.0	-0.9	1.0	-0.7
Had other major operations	1.6	1.9	3.6	1.9	1.3	1.1	1.1
Forced vital capacity (FVC)	0.6	2.1	6.2	-2.5	-0.8	-0.8	1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	7.6	-0.1	2.8	1.1	-1.1
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.0	-0.4	-1.7	-1.0	0.0
Qualifications: None of the above	0.3	0.7	1.7	-1.3	1.0	-0.0	0.4
Financial difficulties in last 2 years	0.4	0.5	1.2	1.1	0.0	0.3	-0.8
Mouth/teeth dental problems	2.4	3.6	7.3	0.2	-2.0	-1.7	2.7
Heart attack	0.5	0.6	1.2	0.4	-1.1	-0.4	1.0
Allergy	26.2	60.3	166.4	-0.1	-5.5	-6.7	12.9
Pain all over the body in last month	1.4	1.6	3.2	-0.3	-0.4	-1.8	1.7
Diabetes (self-reported)	0.2	0.3	0.8	-0.3	-0.2	0.3	0.9
Hayfever/allergic rhinitis (self-reported)	14.2	18.8	54.0	-0.4	3.3	3.2	-7.3
Medication: Ramipril	1.3	1.7	5.8	0.2	-2.4	-0.3	0.9
Medication: Simvastatin	0.4	0.5	1.0	0.7	-0.7	0.5	1.0
Fluid intelligence score	0.4	0.8	2.2	0.7	0.4	0.5	-1.5
Illnesses of siblings	1.2	1.7	3.2	-0.2	0.9	1.8	-1.7
Neuroticism score	0.1	0.2	0.7	0.1	0.3	-0.8	-0.1
Weight	0.2	1.0	3.9	0.5	0.0	0.1	2.0
Impedance of arm (right)	0.6	2.6	9.7	-0.3	0.2	0.7	-3.1
Arm fat percentage (right)	0.5	1.8	3.4	1.8	0.9	1.8	0.2
Trunk fat-free mass	0.7	3.7	9.1	-1.1	-0.5	-2.1	3.0
Hip circumference	0.2	0.7	1.6	0.7	0.1	0.8	1.3
Time employed in main current job	0.9	1.1	3.6	0.2	-1.9	-0.8	0.4
Alcohol intake versus 10 years previously	0.2	0.3	0.8	-0.6	0.4	-0.1	-0.9
Father’s age at death	0.2	0.2	0.6	-0.8	-0.4	-0.0	-0.5
Worrier / anxious feelings	0.3	0.6	1.3	0.0	1.0	0.1	-1.1
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	9.2	-3.0	-1.2	0.7	0.2
Falls in the last year	1.0	1.3	3.8	0.4	0.7	2.0	-0.9
Hair/balding pattern: Pattern 3	0.9	1.3	2.4	1.5	0.5	0.6	-1.5
Number of live births	0.7	1.1	1.9	-1.2	-0.8	0.6	1.4
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	5.4	-2.3	-0.3	-0.4	1.5
Pulse rate	0.8	1.4	4.0	-0.7	-0.4	2.0	-1.0
Happiness	1.2	1.4	2.6	0.1	-1.6	-0.8	-1.6
Noisy workplace	0.5	0.6	1.4	-0.0	-1.2	-0.6	-0.8
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	-0.2	-0.4	0.4	-0.6
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	4.4	2.1	-0.3	-0.7	0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	-0.3	-0.6	0.7	0.0
Asthma	7.2	14.3	32.5	0.3	1.5	4.7	-5.7
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	6.3	-1.2	-2.5	0.1	0.5
Medication: Cholesterol lowering	0.9	1.3	3.1	1.7	-0.6	0.1	1.4
Depression (self-reported)	0.5	0.5	1.8	-0.2	0.2	0.5	-1.4
Medication: Lansoprazole	0.8	0.9	1.6	0.1	-1.2	-1.0	1.1
Prospective memory result	0.5	0.6	2.2	0.3	-1.5	0.4	0.4
Lung cancer (father)	0.5	0.6	1.4	0.4	1.2	0.8	-0.5
Illnesses of mother	0.8	0.9	2.7	1.0	1.7	-0.2	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	4.7	-1.6	-0.1	-1.5	2.2
Pulse wave Arterial Stiffness index	0.9	1.1	2.1	0.3	-0.9	-1.5	1.2
Impedance of arm (left)	0.5	2.4	9.2	0.4	0.2	0.4	-3.0
Arm fat mass (right)	0.3	1.1	1.6	1.3	0.6	1.1	1.0
Trunk predicted mass	0.6	3.6	8.4	-1.1	-0.6	-2.1	2.9
Standing height	0.6	5.7	12.0	-2.3	-1.5	-3.5	1.9
Length of working week for main job	1.8	1.9	3.3	-1.3	1.2	1.8	-1.2
Exposure to tobacco smoke at home	1.1	1.2	3.3	0.8	1.8	-0.7	0.6
Breastfed as a baby	4.2	5.3	13.5	1.0	-2.1	-3.7	1.4
Tense / ‘highly strung’	0.2	0.3	0.9	0.6	-0.2	0.3	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	0.9	0.5	-0.1	-0.1
Hair/balding pattern: Pattern 4	0.4	0.9	1.5	1.2	-0.8	-1.1	-0.1
Birth weight of first child	0.9	1.7	5.9	1.0	-0.2	-2.4	-0.1
Peak expiratory flow (PEF)	1.0	2.4	5.2	-1.9	-0.5	-0.6	2.3
Pulse wave reflection index	1.0	1.2	3.5	-0.3	-0.0	-1.9	1.2
Ever highly irritable/argumentative for 2 days	1.4	1.7	5.0	-2.2	-1.2	-0.5	-0.1
Loud music exposure frequency	2.9	3.2	10.4	-0.6	0.1	1.4	-3.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.2	-0.2	-0.6	1.1	-0.4
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.2	1.3	1.3	0.8	-1.5
Blood clot in the leg (DVT)	0.0	0.1	0.1	-0.0	0.4	0.3	0.1
Medication: Paracetamol	0.3	0.5	1.0	0.2	-0.8	-1.0	0.6
Headache pain in last month	0.3	0.4	1.0	-1.0	-0.6	0.6	-0.3
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	4.1	-1.7	1.6	1.9	-2.0
Glaucoma (self-reported)	0.1	0.1	0.3	0.0	0.3	0.1	-0.6
Gout (self-reported)	0.4	0.6	1.8	0.3	-0.4	-0.6	1.3
Hypothyroidism/myxoedema (self-reported)	4.1	8.0	16.2	-0.8	-0.5	3.9	-4.0
Medication: Amlodipine	2.1	2.9	7.2	0.4	-2.7	-1.5	1.5
Medication: Ventolin 100micrograms inhaler	4.0	5.1	12.0	-0.6	0.9	2.7	-3.5
Birth weight	1.1	2.4	6.9	-0.2	1.5	-2.6	0.7
Chronic bronchitis/emphysema (mother)	1.0	1.2	4.5	0.1	0.2	2.1	0.3
High blood pressure (siblings)	2.5	3.6	7.9	-0.2	-1.0	-2.8	2.3
Forced vital capacity (FVC), Best measure	0.6	2.0	4.9	-2.2	-0.5	-1.2	1.2
Body fat percentage	0.4	1.5	4.7	1.1	0.2	2.2	-0.0
Leg fat percentage (right)	0.6	2.1	8.1	0.1	0.6	2.9	0.1
Arm fat-free mass (right)	0.6	3.1	8.8	-1.4	-0.4	-1.3	3.0
Exposure to tobacco smoke outside home	0.6	0.7	2.2	0.2	0.3	0.7	1.5
Comparative body size at age 10	0.5	1.4	2.8	1.6	1.7	-0.2	0.6
Number of full brothers	0.1	0.2	0.3	0.2	0.6	-0.5	-0.3
Worry too long after embarrassment	0.5	0.9	1.5	-1.2	-1.2	-0.7	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	3.9	2.0	0.1	-0.1	-1.5
Wheeze or whistling in the chest in last year	2.8	5.0	12.6	0.3	0.7	2.6	-3.5
Number of children fathered	2.1	2.3	7.2	-0.2	-1.0	-2.7	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.9	0.2	-1.0	-0.9	0.4
Age at first live birth	1.9	3.4	5.2	2.3	-1.1	-2.0	1.8
Pulse wave peak to peak time	0.7	0.8	1.2	-0.3	0.8	1.1	-1.1
Health satisfaction	0.9	1.2	3.4	1.1	-1.9	0.2	-0.1
Shortness of breath walking on level ground	0.7	0.9	2.3	-0.7	-1.5	-0.8	0.4
Qualifications: College or University degree	1.3	4.2	10.9	3.3	-1.7	1.6	-0.8
Eye problems/disorders: None of the above	0.4	0.5	1.1	-1.1	0.3	0.5	-0.7
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	0.3	0.1	0.3	-0.3
Emphysema/chronic bronchitis	0.9	1.0	3.1	0.3	1.8	0.6	-0.6
Medication for pain relief, constipation, heartburn	1.4	2.5	4.8	-0.6	2.2	1.1	-1.9
Neck or shoulder pain in last month	1.7	2.4	6.1	-1.5	-0.9	2.5	0.6
Medication: Blood pressure	3.1	5.5	8.8	2.1	-1.9	-3.0	2.4
Angina (self-reported)	0.7	0.9	2.7	0.6	-1.6	-0.4	0.7
Migraine (self-reported)	0.7	0.9	3.0	-0.0	-0.5	-0.6	1.7
Medication: Ibuprofen	3.6	4.4	12.6	-2.1	-3.5	0.5	0.6
Medication: Allopurinol	0.7	0.9	2.6	1.6	0.6	-0.4	0.8
Medication: Omeprazole	0.2	0.2	0.4	0.6	-0.4	0.6	0.3
Medication: Seretide 50 evohaler	2.1	2.4	7.2	-0.7	0.4	1.3	-2.7
Mean time to correctly identify matches	0.1	0.2	0.7	0.1	0.2	0.8	0.4
Heart disease (mother)	1.1	1.3	2.5	-1.6	-1.0	0.9	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.3	1.1	-0.2	-0.3	-0.2
Whole body fat mass	0.2	0.8	1.9	0.6	0.1	1.4	0.9
Leg fat mass (right)	0.3	1.1	3.5	0.0	0.4	1.9	0.9
Arm predicted mass (right)	0.5	2.6	7.8	-1.2	-0.2	-1.0	2.8
Pulse rate, automated reading	0.6	1.8	3.1	-1.8	-0.3	1.6	-1.3
Alcohol intake frequency.	0.5	1.3	2.0	0.2	1.4	1.4	-1.1
Comparative height size at age 10	0.4	2.4	6.2	-0.0	-1.6	-2.5	0.7
Number of full sisters	0.3	0.3	1.1	-0.3	1.0	-0.0	-0.2
Suffer from ‘nerves’	0.9	1.4	4.7	-2.2	0.2	0.9	0.0
Overall health rating	0.2	0.3	0.9	0.9	-0.6	-0.4	0.1
Chest pain or discomfort	0.4	0.6	1.1	0.1	-0.1	-1.0	-1.1
Had major operations	0.7	0.8	1.7	1.0	0.6	0.1	-1.3
Age at last live birth	1.1	1.6	3.1	1.1	-0.1	-1.8	1.4
Family relationship satisfaction	0.5	0.6	1.7	-0.3	-0.1	0.8	-1.3
Leg pain on walking	2.2	2.7	5.2	1.3	-2.3	-2.0	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.0	-1.0	0.7	0.2	-0.2
Commuting to job workplace: Car/motor vehicle	1.7	1.9	4.0	0.7	-1.5	-1.0	2.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.8	-0.0	-0.9	-0.8	0.9
Medication: Aspirin	1.1	1.4	2.9	1.7	-0.9	-0.4	1.3
Supplements: Vitamin C	0.9	1.1	4.3	0.3	0.3	-2.1	-0.1
Knee pain experienced in last month	1.6	2.5	6.0	-0.7	-2.4	0.8	1.7
Hypertension (Self-reported)	1.5	4.2	6.8	0.3	-2.4	-2.6	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.9	-0.0	-0.8	0.1	1.0
Illnesses of father: Heart disease	1.2	1.7	4.1	0.3	-2.0	-0.5	1.5
Illnesses of siblings: Diabetes	0.5	0.6	1.2	0.2	0.9	0.6	-1.1
Smoking status: Previous	0.1	0.1	0.3	0.4	-0.1	0.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	6.0	-2.4	-0.3	-0.5	0.8
Whole body fat-free mass	0.6	3.2	8.2	-1.1	-0.4	-1.8	2.9
Leg fat-free mass (right)	0.3	1.8	5.0	-0.5	-0.1	-1.4	2.2
Arm fat percentage (left)	0.5	2.1	4.2	2.0	0.7	1.9	0.1
Average weekly red wine intake	1.0	1.5	3.3	-0.9	-1.8	0.3	1.4
Handedness (chirality/laterality): Left-handed	2.0	2.4	6.7	-0.4	2.6	1.5	-0.6
Mood swings	0.3	0.5	0.8	-0.7	0.9	-0.6	0.3
Loneliness, isolation	0.6	0.8	2.5	0.6	0.7	-0.1	-1.6
Long-standing illness, disability or infirmity	1.2	1.9	3.6	0.8	-0.2	1.8	-1.9
Ever had bowel cancer screening	2.2	2.6	6.5	2.5	-1.2	-1.2	1.0
Diabetes diagnosed by doctor	0.3	0.5	1.1	0.6	-0.6	0.3	1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.9	0.1	-0.6	-1.7	1.4
Friendships satisfaction	1.6	2.0	3.9	2.0	0.3	-0.9	-1.8
Qualifications: nursing, teaching	1.0	1.6	4.4	0.9	-2.1	1.1	-0.3
Commuting to job workplace: Walk	0.3	0.3	1.0	0.6	0.2	0.2	-1.0
Eye problems/disorders: Cataract	0.8	0.9	2.5	1.6	0.6	-0.4	0.7
Mouth/teeth dental problems: Mouth ulcers	4.7	7.4	13.5	-1.3	3.0	2.3	-3.7
Medication for cholesterol	0.6	1.0	1.9	1.1	0.6	0.7	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.9	-0.1	0.2	-1.4	0.2
Back pain experienced in last month	0.6	0.9	2.2	-1.5	-1.0	0.5	0.2
Mineral and other dietary supplements	1.1	1.5	3.0	-0.1	1.6	1.7	-0.7
Breast cancer (self-reported)	1.1	1.3	4.6	-0.6	2.1	-0.2	-0.1
Asthma (self-reported)	6.7	13.4	29.4	0.2	1.2	4.8	-5.4
Osteoporosis (self-reported)	0.4	0.5	0.8	-0.8	0.9	0.5	0.6
Osteoarthritis (self-reported)	0.2	0.3	0.8	-0.6	0.1	0.9	-0.0
Medication: Aspirin	1.2	1.6	2.4	1.6	-1.2	-0.6	1.6
Medication: Gliclazide	1.4	1.6	3.8	1.9	1.6	0.1	0.3
Illnesses of father: None of the above (group 1)	3.8	4.7	11.4	-1.0	1.6	3.4	-2.0
Smoking status: Current	0.9	1.4	4.2	-2.0	-0.9	-0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.0	0.5	-0.2	-0.8	1.7
Whole body water mass	0.5	3.0	8.0	-1.0	-0.3	-1.7	2.8
Leg predicted mass (right)	0.3	1.7	4.7	-0.6	-0.1	-1.3	2.2
Arm fat mass (left)	0.3	1.1	2.0	1.4	0.3	1.1	1.0
Number of self-reported non-cancer illnesses	1.2	2.1	6.9	0.3	-0.5	1.1	-2.6
Average weekly champagne plus white wine intake	1.7	2.4	8.5	2.9	0.4	0.3	-0.8
Miserableness	0.1	0.1	0.1	-0.3	-0.2	0.3	0.3
Guilty feelings	0.7	1.1	3.3	-0.6	-0.8	-1.8	0.5
Wears glasses or contact lenses	1.2	1.3	3.3	0.0	-1.8	-0.9	1.1
Ever taken oral contraceptive pill	0.8	0.9	3.1	0.1	-0.4	-0.7	1.7
Hearing aid user	0.8	0.9	2.7	1.6	-0.5	-0.5	0.6
Mother’s age at death	1.3	1.6	2.3	1.5	-1.5	-0.8	1.0
Financial situation satisfaction	1.3	1.6	4.9	0.2	0.1	1.2	-2.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.1	0.7	1.0	-1.0	-0.6
Commuting to job workplace: Public transport	0.8	1.0	2.6	-0.9	0.6	1.6	-0.5
Eye problems/disorders: Glaucoma	0.1	0.2	0.5	-0.3	0.1	-0.4	0.7
Medication: Blood pressure	0.6	1.2	2.3	-0.4	-1.2	-0.9	1.5
Pain type(s) experienced in last month: Hip pain	0.9	1.2	3.0	-0.4	-1.7	-0.3	1.2
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.9	-0.0	-1.3	-2.0	0.8
High cholesterol (Self-reported)	0.6	1.1	3.1	-0.7	-0.9	0.1	1.8
Medication: Bendroflumethiazide	0.9	1.4	3.5	-0.2	-1.2	-1.9	0.8
Medication: Paracetamol	0.8	1.3	2.0	-1.4	-1.3	-1.1	0.7
Medication: Lisinopril	0.9	1.1	2.7	0.6	-1.1	-1.6	-0.6
Medication: Atorvastatin	0.2	0.2	0.4	0.3	0.0	0.6	-0.6
Illnesses of father: High blood pressure	2.4	3.0	11.9	0.1	0.4	-3.4	0.3
Alcohol drinker status: Never	0.9	1.1	2.3	-0.7	1.2	-0.2	-1.5
Ever smoked	0.8	1.4	3.2	-1.8	-1.6	0.2	-0.0
Basal metabolic rate	0.4	2.3	6.6	-0.8	-0.2	-1.4	2.6
Leg fat percentage (left)	0.5	1.8	6.4	0.4	0.6	2.5	0.5
Arm fat-free mass (left)	0.5	2.7	7.3	-1.5	-0.3	-1.0	2.7
Number of operations (self-reported)	0.3	0.5	1.5	1.2	0.3	0.6	0.1
Average weekly beer plus cider intake	0.4	0.6	1.1	-0.4	1.1	0.6	-0.9
Irritability	1.1	1.8	3.1	0.4	-1.8	-1.7	1.0
Risk taking	0.7	1.0	2.4	-0.3	-1.6	1.1	-0.7
Ever had prostate specific antigen (PSA) test	1.4	1.6	2.5	1.6	-1.1	-1.2	1.1
Fractured/broken bones in last 5 years	0.9	1.1	2.5	-0.7	-1.6	0.3	1.2
Age started oral contraceptive pill	0.3	0.3	0.5	0.7	0.3	0.7	0.5
Diastolic blood pressure, automated reading	0.5	1.4	3.0	0.4	-1.4	-1.7	0.8
Ever depressed for a whole week	1.9	2.4	8.2	-0.8	-2.9	0.4	-0.7
Unable to work because of sickness or disability	0.2	0.2	0.9	-0.2	-0.2	0.9	-0.2
Commuting to job workplace: Cycle	1.4	1.7	4.2	-0.1	1.1	1.1	-2.1
Myopia	0.8	1.1	3.2	-0.1	-1.8	1.1	-0.2
Vascular/heart problems diagnosed by doctor	1.9	5.3	11.0	-0.1	2.5	3.3	-2.0
Cholesterol lowering medication	1.4	2.1	4.7	-0.9	-1.7	-0.3	2.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.6	1.3	0.1	-0.3	-0.0
Pain experienced in last month	2.1	3.5	6.6	2.6	1.8	0.3	-2.0
Supplements: Calcium	0.4	0.5	1.0	-0.4	0.6	-0.7	1.0
Basal cell carcinoma (self-reported)	2.0	2.3	6.7	1.2	-1.1	-0.1	2.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.3	0.4	-1.1	-0.3	0.8
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.1	-0.1	0.3	-0.0	0.4
Heart disease (siblings)	1.2	1.5	2.7	1.2	-1.3	-0.3	1.6
Alcohol drinker status: Previous	0.9	1.1	1.7	-1.3	-0.6	1.1	-1.1
Pack years of smoking	0.6	0.8	2.1	-0.0	-0.8	1.4	-0.8
Impedance of whole body	0.5	2.3	7.8	-0.8	0.1	0.9	-2.8
Leg fat mass (left)	0.3	1.1	3.1	0.2	0.3	1.8	1.0
Arm predicted mass (left)	0.6	3.2	9.2	-1.5	-0.3	-1.0	3.0