Hub : Genes

SPEF2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1870 0.0380 3.3e-16 0.126 0.156 0.171 0.167 0.178 4.7e-15 1.7e-18 2.3e-20 6.8e-20 3.7e-21
2 GTEx Artery Aorta 0.1210 0.0440 2.2e-03 0.032 NA 0.032 NA 0.039 7.2e-03 NA 6.9e-03 NA 3.3e-03
3 GTEx Artery Tibial 0.1315 0.0439 9.5e-04 0.053 NA 0.085 NA 0.107 5.7e-05 NA 3.3e-07 NA 1.0e-08
4 GTEx Brain Cerebellar Hemisphere 0.2260 0.1000 9.9e-03 0.005 NA 0.002 NA 0.001 2.3e-01 NA 2.8e-01 NA 3.0e-01
5 GTEx Brain Cerebellum 0.1650 0.0670 9.7e-03 0.189 NA 0.139 NA 0.177 2.9e-06 NA 6.8e-05 NA 6.5e-06
6 GTEx Brain Cortex 0.5990 0.0800 2.6e-10 0.469 NA 0.399 NA 0.420 1.2e-14 NA 4.0e-12 NA 7.4e-13
7 GTEx Brain Frontal Cortex BA9 0.3911 0.0895 2.2e-05 0.228 NA 0.218 NA 0.194 1.0e-06 NA 1.8e-06 NA 7.5e-06
8 GTEx Brain Nucleus accumbens basal ganglia 0.3150 0.1050 1.8e-03 0.243 NA 0.162 NA 0.188 3.5e-07 NA 4.1e-05 NA 9.1e-06
9 GTEx Cells Transformed fibroblasts 0.2580 0.0650 6.7e-07 0.011 NA 0.045 NA 0.045 4.4e-02 NA 2.6e-04 NA 2.6e-04
10 GTEx Nerve Tibial 0.1599 0.0546 6.9e-04 0.009 NA 0.084 NA 0.046 7.3e-02 NA 1.6e-06 NA 3.4e-04
11 GTEx Testis 0.3280 0.0780 2.7e-05 0.066 NA 0.214 NA 0.198 6.8e-04 NA 7.5e-10 NA 3.4e-09
12 METSIM Adipose 0.0595 0.0195 2.4e-05 0.011 0.028 0.018 0.028 0.020 7.3e-03 4.0e-05 8.6e-04 4.0e-05 4.7e-04
13 ROSMAP Brain Pre-frontal Cortex 0.3066 0.0381 0.0e+00 0.305 0.366 0.394 0.385 0.396 7.5e-40 2.6e-49 4.1e-54 1.5e-52 1.9e-54
14 TCGA Breast Invasive Carcinoma 0.0936 0.0280 4.0e-09 0.050 0.052 0.055 NA 0.053 1.7e-10 5.9e-11 2.0e-11 NA 4.4e-11
15 TCGA Glioblastoma Multiforme 0.1650 0.0670 4.4e-04 0.005 0.081 0.048 NA 0.044 2.2e-01 1.8e-03 1.4e-02 NA 1.8e-02
16 TCGA Head and Neck Squamous Cell Carcinoma 0.0355 0.0150 2.9e-04 0.028 0.022 0.026 NA 0.025 3.3e-04 1.4e-03 5.9e-04 NA 7.5e-04
17 TCGA Kidney Renal Clear Cell Carcinoma 0.1690 0.0450 5.6e-10 0.032 0.084 0.071 NA 0.076 1.5e-04 1.0e-09 2.0e-08 NA 6.3e-09
18 TCGA Kidney Renal Papillary Cell Carcinoma 0.0950 0.0520 7.2e-03 0.005 0.010 0.001 NA 0.009 1.6e-01 8.1e-02 2.6e-01 NA 9.1e-02
19 TCGA Brain Lower Grade Glioma 0.0294 0.0146 3.2e-03 0.037 0.023 0.022 NA 0.024 4.1e-05 1.2e-03 1.5e-03 NA 8.4e-04
20 TCGA Ovarian Serous Cystadenocarcinoma 0.0810 0.0430 6.6e-03 0.069 0.013 0.028 NA 0.037 1.9e-05 4.1e-02 5.1e-03 NA 1.5e-03
21 TCGA Pheochromocytoma and Paraganglioma 0.2200 0.0780 2.0e-04 0.051 0.092 0.167 NA 0.168 4.2e-03 1.7e-04 3.5e-07 NA 3.2e-07
22 TCGA Prostate Adenocarcinoma 0.1187 0.0458 6.0e-05 0.077 0.049 0.056 NA 0.059 1.9e-08 6.6e-06 1.7e-06 NA 9.2e-07
23 TCGA Thyroid Carcinoma 0.3500 0.0690 4.4e-16 0.108 0.208 0.238 NA 0.230 1.1e-10 5.4e-20 5.9e-23 NA 3.8e-22

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Bipolar Disorder (2018) 0.7 1.1 3.0 1.0 0.1 1.0 1.7 1.0 0.9 -0.3 0.8 -1.7 0.4 -0.5 1.1 1.1 1.3 1.2 -0.9 0.8 -0.8 0.7 1.0 1.4 1.5 0.6
Bipolar Disorder or Schizophrenia 0.2 0.4 2.7 -0.1 -0.0 0.0 1.1 -0.0 0.6 -1.2 -0.8 -0.2 -1.7 -1.3 -0.1 0.1 -0.2 -0.1 -0.6 0.3 -0.4 -0.7 -0.2 0.7 0.1 -0.4
Depressed Affect (Nagel 2018) 0.3 0.7 1.6 -0.8 1.1 0.7 -1.0 -1.1 -1.1 0.1 -0.2 1.0 0.4 0.8 0.8 -1.0 0.5 -0.8 1.1 0.2 1.0 -0.2 1.2 0.1 0.8 0.8
Depression (Nagel 2018) 0.5 0.8 3.2 0.9 -1.2 -0.9 -0.1 0.6 0.8 0.7 1.1 0.7 -0.3 -1.8 -0.4 0.8 -1.2 0.2 -0.3 -1.0 -1.1 0.9 -0.8 -0.8 -0.9 -1.4
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.9 1.0 -0.2 1.0 0.3 0.5 0.4 1.1 1.4 0.8 1.3 1.0 -0.2 0.9 0.7 0.7 -0.3 -0.1 0.1 1.2 1.0 0.5 1.3 0.9
Neuroticism (Nagel 2018) 0.3 0.7 2.1 0.0 0.7 1.5 -0.1 -1.1 -0.7 0.8 1.0 0.5 0.6 0.3 1.1 -0.2 1.1 0.4 0.5 0.7 0.3 1.0 1.2 0.3 1.2 1.1
Schizophrenia (2018) 0.5 1.1 6.2 -1.0 -0.1 -0.8 0.0 -0.9 0.0 -1.3 -1.6 1.2 -2.5 -1.3 -1.0 -0.7 -1.3 -1.1 -0.0 -0.2 0.1 -1.4 -1.1 -0.2 -1.1 -1.0
Schizophrenia vs Biploar Disorder 0.5 0.7 3.2 0.5 -1.2 -0.7 0.9 0.8 1.1 1.1 0.4 0.5 -0.5 -0.5 -1.3 1.1 -0.2 1.3 -1.8 -0.2 -0.1 0.5 -0.6 -0.4 -0.1 -0.7
Worry (Nagel 2018) 0.2 0.5 2.1 0.3 -0.3 0.8 1.4 -0.4 0.2 0.7 0.7 -1.2 -0.2 0.2 0.2 0.5 1.1 1.2 -1.0 0.4 -0.4 0.8 0.1 -0.5 0.5 0.5
Alzheimer’s Disease (in mother) 0.6 0.7 2.2 -0.3 0.4 0.9 -0.1 -0.7 -1.2 -0.0 0.5 -0.4 0.3 1.1 -0.7 -0.5 1.5 0.4 0.4 1.4 1.2 0.4 0.8 0.8 0.8 1.5
Alzheimer’s Disease (in father) 1.7 1.8 5.8 -0.6 1.9 1.4 -1.3 -1.1 -1.0 -1.0 -1.0 1.2 0.4 0.1 2.4 -1.5 0.1 -2.0 2.2 1.3 1.9 -0.9 0.8 1.6 0.4 1.2
Alzheimer’s Disease (including proxy) 0.9 1.2 3.5 -0.4 1.4 1.4 -0.6 -1.0 -1.3 -0.2 0.0 0.1 0.8 0.8 1.4 -1.0 1.5 -0.6 1.3 1.6 1.5 -0.0 1.0 1.7 0.7 1.9
Crohns Disease (2017) 0.3 0.7 3.0 -1.2 -0.7 -1.1 -0.2 -0.7 -0.5 -1.3 -0.7 -1.4 -1.1 0.6 -1.7 -0.4 -0.6 -0.8 -0.5 -0.5 1.0 -0.7 0.1 -0.6 -0.0 -0.9
Irritable Bowel Disease (IBD) 0.6 1.4 4.2 0.8 -2.1 -1.2 0.5 1.1 1.4 0.5 0.7 -1.2 -1.2 -1.9 -0.8 1.4 -1.2 0.5 -1.6 -0.2 -0.6 0.9 -1.2 -0.9 -0.9 -2.0
Ulcerative Colitis (UC) 1.5 2.9 10.1 2.3 -2.1 -0.7 0.8 2.3 2.6 1.7 1.6 -0.2 -0.7 -3.2 0.8 2.4 -1.2 1.4 -1.7 0.1 -1.9 1.9 -1.6 -0.4 -1.1 -2.0
Major Depression (MDD) 1.2 1.4 5.5 0.2 0.2 1.5 2.0 -0.2 0.1 0.7 0.8 -0.0 1.6 1.6 0.2 0.5 2.3 1.6 -1.1 1.5 -0.1 1.0 1.1 1.2 1.6 1.4
Reaction Time 0.6 1.2 3.0 1.7 0.1 1.0 1.3 1.7 1.6 1.1 0.8 -0.3 1.4 -1.6 1.6 1.5 0.1 1.6 -0.6 0.3 -0.3 0.9 0.1 0.7 0.6 0.7
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.7 1.0 -0.8 0.1 1.2 1.1 1.1 1.6 1.6 0.3 0.7 0.3 0.2 1.4 0.6 1.5 -1.6 -0.6 -0.5 1.3 0.4 0.1 0.8 0.1
Breast Cancer 2.6 6.3 12.4 1.0 -3.2 -3.3 2.8 2.9 2.9 0.2 -0.6 -3.4 -2.2 -1.6 -2.9 2.3 -2.3 1.4 -3.5 -3.5 -3.2 -0.6 -2.5 -1.8 -2.0 -3.1
Ovarian Cancer 0.2 0.2 1.0 0.3 1.0 1.0 0.5 0.2 -0.1 -0.5 0.2 -0.0 0.2 0.1 0.0 0.2 -0.4 0.6 0.2 0.3 0.4 0.1 0.4 -0.1 0.6 0.9
Prostate Cancer 0.2 0.2 1.2 0.5 0.4 -0.1 0.3 0.7 0.7 -0.7 -0.4 -0.3 -0.1 -0.7 0.1 0.3 -1.1 -0.6 -0.0 -0.3 -0.5 -0.3 -0.1 -0.4 -0.1 -0.9
Age at First Birth 0.3 0.4 1.6 -0.4 0.1 -0.3 -0.1 0.0 0.2 -1.0 -1.3 0.0 -0.5 -0.1 -0.4 -0.5 -1.0 -0.9 0.7 -0.5 0.1 -1.3 0.2 0.9 0.2 -0.4
Bipolar Disorder (2011) 1.9 1.8 6.0 -1.4 2.4 1.1 -1.9 -1.2 -1.5 -1.7 -1.1 1.3 -0.1 0.0 1.8 -1.6 0.2 -2.0 1.7 0.7 1.2 -1.2 1.3 0.8 0.7 0.9
Body Mass Index (BMI) (2010) 1.0 1.3 4.4 -0.6 -0.9 -2.1 -1.2 -0.2 -0.3 -0.3 -0.4 1.1 -2.0 -1.3 -0.7 -0.6 -1.9 -1.4 0.8 -1.4 0.0 -0.5 -1.1 -0.8 -1.9 -1.5
Coronary Artery Disease (CAD) 0.3 0.4 1.1 -0.7 0.6 0.6 -0.6 -0.7 -1.0 -0.6 -0.7 -0.5 0.4 -0.1 0.1 -0.8 -0.2 -0.9 1.1 0.3 0.8 -0.6 -0.2 -0.3 -0.3 0.7
Crohns Disease (2012) 0.3 0.5 1.4 -1.0 0.7 0.3 -0.5 -1.2 -1.2 -0.8 -0.1 -0.6 -0.6 1.2 0.2 -0.6 0.6 0.0 -0.2 0.4 1.0 0.0 0.9 -0.6 0.8 0.2
Mean Putamen Volume 0.3 0.4 2.1 -0.1 -0.3 -0.6 -0.5 0.6 0.3 -0.1 0.1 -1.0 -1.4 -0.1 0.1 0.5 -0.6 0.4 -0.9 -0.7 -0.2 -0.0 -0.7 -1.3 -0.5 -0.2
Fasting Glucose 1.1 1.3 5.4 -1.2 0.9 0.6 0.2 -0.8 -1.4 -0.9 -1.4 -1.2 0.1 1.3 -0.7 -1.4 0.5 -0.7 0.7 1.3 2.3 -1.2 1.3 1.5 0.8 1.1
HbA1C 0.6 0.7 2.0 0.4 -1.4 -0.6 0.9 0.7 1.1 0.2 0.9 0.4 0.3 -1.0 -0.3 0.8 -0.0 0.7 -1.2 -0.4 -0.8 0.9 -1.1 -1.2 -0.8 -1.1
HDL Cholesterol 0.5 0.8 2.3 1.3 -0.5 0.5 0.8 0.9 1.2 0.8 1.2 -1.5 -0.2 -0.3 0.4 1.3 0.5 1.5 -0.9 0.5 -0.8 1.3 -0.1 -0.7 0.3 -0.1
LDL Cholesterol 0.2 0.3 1.2 0.2 0.2 1.0 1.1 -0.5 0.0 0.2 -0.2 0.6 0.8 0.5 0.6 -0.2 0.8 0.9 0.3 0.7 -0.5 -0.2 0.1 0.5 0.5 0.8
Lupus 0.4 0.6 2.3 0.5 -0.1 -0.1 1.0 0.6 1.4 0.7 0.3 -1.5 1.1 0.0 0.6 1.0 0.3 0.4 -1.5 -1.0 -0.5 0.3 0.7 0.6 1.1 -0.1
Neuroticism (2016) 0.7 1.0 3.2 0.4 -1.1 -0.8 -0.9 0.6 0.5 0.7 0.8 -0.8 0.2 -1.4 1.0 0.7 -1.2 0.2 -0.7 -1.8 -1.8 0.8 -1.1 -1.5 -1.1 -1.2
Primary Biliary Cirrhosis 1.2 1.7 11.6 -1.5 -0.6 -0.6 1.2 -0.3 -0.2 -1.4 -1.7 -3.4 -0.1 1.2 -2.0 -0.5 0.5 -1.5 -1.1 -0.5 1.6 -1.6 0.7 1.1 0.8 -0.1
Rheumatoid Arthritis 0.5 0.7 3.7 1.0 -0.9 -0.5 0.2 0.9 0.9 -0.0 0.9 -1.0 -0.2 -1.9 -0.5 1.1 -0.9 0.2 -0.8 0.1 -1.0 0.8 -0.6 -0.7 -0.5 -1.5
Schizophrenia (2014) 0.2 0.5 2.1 -0.4 0.5 0.8 0.7 -0.7 -0.1 -0.5 -0.4 1.2 -1.0 -0.4 0.1 -0.2 0.9 0.2 -0.3 1.4 0.4 -0.2 0.5 1.5 0.8 0.7
Triglycerides 0.4 0.6 2.2 -0.6 -0.5 -1.2 0.2 0.1 -0.2 -0.7 -1.0 1.2 0.1 -0.3 -0.4 -0.4 -1.5 -0.6 0.2 -1.1 -0.4 -0.9 -1.1 -0.7 -1.5 -0.8
Type 2 Diabetes (T2D) (2012) 0.4 0.4 2.2 0.3 -0.1 -0.7 1.0 0.3 0.5 -0.2 0.1 0.0 -1.5 -0.5 0.0 0.6 -0.5 0.3 -0.6 0.1 -0.7 0.2 -0.9 -0.8 -1.0 -1.2
Ulcerative Colitis 1.7 2.4 6.2 2.4 -1.5 0.1 1.8 1.7 2.3 1.9 1.8 -0.5 -0.3 -2.5 0.8 2.4 0.0 1.9 -1.9 0.7 -1.6 2.0 -0.8 -0.2 -0.0 -1.3
Blood Eosinophil Count 1.7 13.3 45.4 -3.3 -0.0 -2.3 -0.8 -0.9 -1.3 -6.3 -5.3 -6.0 -2.2 1.7 -6.7 -2.5 -3.7 -6.5 0.4 -1.4 5.3 -5.4 0.0 0.2 -0.8 -2.7
Blood Platelet Count 0.1 1.2 4.5 0.7 -1.4 -1.3 -0.4 0.9 0.2 0.5 0.9 -0.3 0.4 -2.1 0.5 0.5 -2.1 0.3 0.3 -0.9 -1.0 1.1 -1.5 -0.9 -1.9 -1.5
Blood Red Count 0.0 0.4 2.0 0.3 -0.1 -0.7 0.6 0.0 0.1 -0.8 -0.8 1.4 -1.2 0.4 -0.1 -0.2 0.4 -0.0 0.5 0.5 -0.6 -0.6 -0.4 0.2 -0.4 -0.5
Blood White Count 0.4 3.3 11.2 3.1 -1.1 1.1 3.4 1.4 1.8 1.2 2.9 -0.6 -0.3 -2.4 -1.4 2.3 -0.3 0.6 -0.3 1.8 -1.7 3.1 -2.0 -0.7 -1.2 -1.4
Heel T-Score 0.1 0.5 5.2 0.0 -0.0 -1.2 -2.3 0.8 0.3 -0.2 -0.2 -0.7 -0.1 0.9 -0.8 0.0 -0.4 -0.7 0.1 -1.4 -0.1 -0.4 -0.1 -0.0 -0.5 -0.4
BMI 0.2 1.4 7.3 0.7 -1.2 -1.8 0.6 1.2 1.6 1.7 0.3 -0.5 -0.8 -0.2 0.1 1.1 -1.0 0.6 -1.4 -2.7 -0.9 0.3 -0.9 -1.7 -0.9 -1.0
Height 0.5 10.6 44.3 2.7 2.4 4.3 -0.4 -0.6 0.7 3.9 2.4 6.7 1.9 1.6 5.4 0.1 4.8 1.8 2.9 4.5 0.1 2.7 3.5 3.3 3.7 3.3
Waist Hip Ratio (WHR) 0.2 1.0 2.8 1.2 -0.8 0.2 1.1 1.4 0.7 0.6 1.5 -1.1 1.5 -0.8 0.4 1.5 0.4 1.2 -1.3 0.3 -1.4 1.7 -0.8 -0.4 -0.4 -0.2
Systolic Blood Pressure 0.1 0.3 1.4 -0.1 0.4 0.7 -0.2 -0.4 -0.7 0.3 0.7 -0.3 1.2 0.1 -0.1 -0.4 0.1 -0.4 0.8 0.8 0.1 0.6 -0.2 -0.6 -0.3 0.4
Smoking Status 0.5 1.3 3.5 1.8 0.3 0.7 1.2 1.0 1.3 1.7 1.9 1.0 0.0 -0.2 0.8 1.5 1.2 1.6 -0.4 0.5 -1.0 1.9 0.6 1.0 1.0 0.5
Allergy or Eczema 5.7 14.9 57.2 -4.8 0.0 -2.5 0.2 -1.8 -2.2 -6.8 -5.7 -7.6 -1.7 3.8 -6.8 -3.0 -1.4 -5.7 -1.1 -0.2 4.5 -5.8 1.0 1.5 0.5 -2.4
Cardiovascular Disease 0.6 2.1 7.7 1.8 -0.4 0.3 -0.1 1.1 0.8 2.4 2.8 0.8 1.4 -2.0 2.4 1.6 0.1 1.7 -0.6 0.0 -1.7 2.7 -0.8 -0.4 -0.5 -0.2
Hypothyroidism (self reported) 1.8 4.0 10.9 -1.4 -1.6 -2.4 1.1 0.5 0.2 -2.5 -2.4 -3.3 -1.8 -1.1 -2.6 -0.5 -3.2 -2.3 -0.7 -2.2 0.3 -2.4 -2.3 -1.5 -2.6 -2.4
Respiratory disease 1.5 3.3 17.8 -1.9 -0.1 -0.3 0.5 -0.8 -0.5 -2.9 -2.9 -4.2 0.1 1.9 -3.4 -1.2 -0.9 -2.2 -0.7 -0.3 2.3 -2.9 0.4 0.9 0.5 -0.4
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.6 1.5 1.2 1.6 -0.2 0.9 0.5 0.7 1.6 0.4 0.6 -0.1 0.5 1.0 0.7 0.8 0.1 1.3 -0.0 1.6 0.5 0.8 0.7 1.0
Lung FEV1/FVC ratio 1.2 6.3 17.4 3.4 -1.6 0.6 2.5 2.6 3.1 4.0 3.0 0.1 2.4 -2.5 3.5 3.2 -0.0 4.2 -2.2 -0.8 -3.2 3.2 -1.6 -1.2 -0.5 0.3
Lung FVC 0.5 2.8 8.3 -2.4 0.7 -0.3 -1.8 -2.6 -2.7 -1.9 -1.3 1.1 -2.1 0.5 -2.9 -2.4 -0.7 -2.2 1.8 0.0 1.4 -1.4 -0.4 -0.8 -1.1 0.0
Neuroticism 0.2 0.4 1.3 0.3 -0.5 0.4 0.2 0.4 0.7 1.0 0.9 -0.2 0.8 -0.5 0.6 0.8 0.3 0.5 -1.1 -1.1 -1.2 0.9 0.2 0.2 0.5 -0.1
Chronotype (morning person) 1.1 2.5 8.6 1.9 -1.3 0.4 2.9 1.5 1.9 1.7 1.4 -2.6 2.2 -0.7 -0.8 1.8 1.5 2.3 -1.6 0.8 -1.0 1.4 -0.0 1.5 0.9 0.6
Hair Pigment 0.1 2.2 5.6 -1.9 1.4 0.3 -2.4 -2.2 -2.1 -1.7 -1.5 -0.1 -0.3 1.5 0.2 -2.1 -0.1 -2.4 2.3 0.0 1.4 -1.5 1.4 -0.4 0.7 -0.1
Tanning 0.1 1.5 5.8 1.5 -0.9 -0.1 0.8 1.0 -0.2 1.8 2.4 2.1 0.2 -1.6 0.3 0.8 -0.2 1.1 0.5 1.2 -0.7 2.4 -1.2 -0.1 -1.2 -0.0
Hand grip strength (left) 0.3 0.9 6.0 0.9 0.2 0.1 0.5 0.4 0.5 0.8 0.3 1.7 0.7 1.0 -0.2 0.1 1.5 -0.2 0.9 0.8 0.2 0.4 1.5 2.5 1.4 0.5
Number of treatments/medications taken 0.6 1.2 4.3 -1.4 0.2 0.0 -1.1 -1.6 -1.5 -2.1 -1.5 -0.6 -0.4 0.5 -1.3 -1.4 -1.1 -1.3 0.8 -0.1 0.9 -1.4 -0.6 -0.6 -0.7 -0.4
Average weekly spirits intake 0.7 0.9 4.1 0.5 -0.2 -0.4 -0.3 0.8 0.7 -0.1 -0.2 -0.2 -1.2 -2.0 -0.6 0.2 -1.7 -0.4 0.3 -1.5 -0.8 -0.1 -1.5 -1.0 -1.6 -0.6
Sensitivity / hurt feelings 1.1 1.9 7.2 2.1 -1.0 -0.2 0.4 1.8 1.8 2.1 2.0 0.4 0.8 -2.7 1.1 1.8 -0.5 1.1 -0.8 -1.2 -1.8 2.0 -0.4 0.3 -0.2 -0.4
Frequency of depressed mood in last 2 weeks 0.8 1.1 2.4 0.8 -1.2 -1.0 0.1 0.9 0.7 1.0 1.6 -0.3 -0.1 -1.5 -0.4 1.2 -1.3 0.5 -1.1 -1.1 -0.8 1.4 -0.8 -1.3 -0.8 -1.5
Hearing difficulty/problems: Yes 1.0 1.5 4.0 -1.2 1.8 1.2 -2.0 -1.6 -1.2 -1.5 -1.2 1.0 -0.5 0.7 1.3 -1.6 -0.1 -1.8 1.7 0.0 0.9 -1.2 0.8 -0.1 0.6 0.7
Relative age of first facial hair 0.4 0.9 3.8 -1.3 -0.6 -0.8 -0.5 -0.6 -1.1 -1.5 -1.0 -2.0 -0.9 0.2 -1.5 -0.8 -0.8 -0.6 -0.1 0.1 0.6 -0.7 -0.8 -1.1 -0.9 -0.5
Other serious medical condition/disability diagnosed by doctor 1.0 1.2 3.8 -1.0 -0.9 -1.7 -0.4 0.0 -0.1 -0.4 -1.0 0.4 -1.8 -0.8 -0.1 -0.4 -1.8 -0.6 -0.3 -1.6 -0.7 -0.9 -1.7 -1.5 -2.0 -1.5
Ever used hormone-replacement therapy (HRT) 0.6 0.7 2.5 0.9 -0.3 0.5 1.0 0.5 0.2 0.8 1.5 0.4 1.6 -0.0 0.8 0.8 0.8 1.1 -0.8 0.9 -0.8 1.5 0.4 0.9 0.6 -0.0
Ever had hysterectomy (womb removed) 1.7 1.9 8.3 1.6 0.6 1.5 -0.4 0.7 0.4 1.3 1.9 2.9 1.9 -0.5 2.4 0.7 1.7 0.7 0.8 2.0 -1.0 1.8 0.5 1.2 0.7 0.4
Systolic blood pressure, automated reading 0.2 0.6 2.2 0.1 0.8 1.2 -0.7 -0.3 -0.3 0.4 0.7 1.3 1.5 1.1 0.1 -0.1 0.8 -0.2 0.4 0.5 -0.1 0.5 1.1 0.5 1.2 0.7
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 1.3 0.0 0.4 0.9 -0.3 -0.3 -0.5 -0.0 0.8 1.1 0.4 0.3 0.3 0.1 0.2 0.3 0.1 0.1 0.3 0.6 0.4 -0.2 0.4 0.8
Angina 0.7 0.9 2.7 1.6 -0.5 -0.2 0.3 1.3 0.8 0.7 1.5 1.2 0.3 -1.2 -0.2 1.2 -0.7 0.7 0.1 0.3 -1.5 1.5 -0.9 -0.4 -0.8 -0.8
Medication for hormone replacement therapy 0.4 0.4 2.1 -0.9 -0.3 -0.1 -0.4 -1.1 -1.4 -0.8 -0.5 0.6 0.1 1.3 0.2 -0.9 0.9 -0.2 0.2 0.3 0.4 -0.3 -0.1 -0.0 -0.1 0.4
Vitamin and mineral supplements 0.4 0.6 3.2 0.0 -0.8 -0.7 1.6 0.6 0.4 -0.1 0.3 0.1 -0.8 -0.6 -0.5 0.8 -0.1 0.9 -1.8 -0.5 -0.9 0.1 -1.0 -0.7 -0.7 -0.5
Supplements: Zinc 0.7 0.8 2.6 -0.7 -0.1 -0.4 -0.8 -0.1 -1.0 -0.6 0.2 -0.6 -1.3 -1.3 -0.8 -0.5 -1.5 -0.7 0.6 -0.9 -0.0 0.1 -1.3 -1.5 -1.6 -0.5
Medication: Co-codamol 0.4 0.5 1.5 0.4 -0.8 -1.2 0.1 1.2 1.0 -0.1 -0.1 -0.6 -0.4 -0.5 0.3 0.8 -1.0 0.2 -1.1 -0.8 -0.6 -0.2 -0.8 -0.3 -0.8 -1.1
Medication: Metformin 0.3 0.4 1.9 0.3 1.0 0.9 -0.8 -0.2 -0.4 -0.0 0.5 1.4 -0.3 -0.1 0.4 -0.0 -0.2 0.2 0.7 0.6 -0.1 0.5 -0.4 -0.9 -0.4 0.7
Diabetes (father) 1.1 1.3 3.6 1.5 -1.9 -1.8 0.3 1.5 1.3 1.1 0.9 0.0 -1.1 -1.8 -0.9 1.2 -1.1 0.7 -0.5 -0.7 -0.9 0.9 -1.1 0.1 -1.1 -1.5
Diabetes (mother) 0.9 1.1 5.3 -0.1 -0.2 -0.8 -0.9 0.6 0.3 -0.8 -0.3 -0.0 -0.5 -1.9 -0.3 -0.1 -2.3 -1.5 0.5 -1.9 -0.7 -0.5 -1.4 -0.9 -1.7 -1.2
Severe depression (siblings) 0.4 0.4 1.5 0.5 -0.3 -0.7 0.8 0.5 0.3 0.9 0.6 0.2 0.1 -0.5 0.9 0.6 -0.6 0.2 -0.3 -0.3 -0.5 0.8 -1.2 -1.0 -1.2 -0.4
Pack years adult smoking proportion 1.6 2.5 5.6 -1.7 2.0 1.2 -1.2 -2.4 -2.2 -1.8 -1.6 0.9 -0.2 1.4 -0.3 -2.4 0.6 -2.1 2.4 0.8 2.0 -1.8 1.2 0.9 0.6 1.4
Impedance of leg (right) 0.3 1.2 5.8 -1.1 0.4 1.0 1.2 -0.7 -1.8 -2.4 -0.6 -1.9 0.3 -0.5 -1.6 -0.7 0.5 -0.0 -0.0 2.2 1.2 -0.5 -0.4 0.4 -0.2 0.6
Leg fat-free mass (left) 0.3 1.6 6.8 1.1 0.4 0.6 0.2 0.3 1.4 2.6 0.5 1.6 0.8 2.3 2.1 0.5 1.8 0.6 0.1 -0.9 -0.7 0.6 1.7 0.6 1.7 0.9
Trunk fat percentage 0.5 2.0 5.5 0.6 -1.4 -1.7 1.1 1.6 1.5 0.4 -0.1 -0.7 -0.9 -1.2 -1.1 1.4 -1.6 1.0 -2.2 -2.3 -1.9 0.0 -1.6 -2.0 -1.3 -1.8
Hand grip strength (right) 0.2 0.4 2.5 0.1 0.2 0.0 0.5 -0.1 -0.1 -0.0 -0.5 0.5 -0.2 1.4 -0.6 -0.4 0.7 -0.7 0.9 0.4 0.5 -0.3 1.0 1.6 0.8 0.3
Townsend deprivation index at recruitment 0.6 0.9 3.8 0.7 -0.9 -0.7 0.8 0.9 1.0 -0.4 0.4 -2.0 -0.0 0.5 -1.4 1.3 -0.5 0.6 -1.8 -0.3 -0.4 0.5 -1.1 -1.2 -0.7 -1.1
Current tobacco smoking 0.4 0.6 3.1 1.2 0.7 0.5 1.2 0.6 0.7 0.9 0.5 1.2 0.1 0.4 -0.1 0.5 1.0 0.2 0.6 0.5 -0.3 0.7 1.0 1.7 1.0 0.5
Average weekly fortified wine intake 0.7 0.9 5.5 1.1 -0.6 -0.6 0.2 0.8 0.7 0.2 0.9 0.1 -1.0 -2.3 0.4 0.6 -1.1 0.0 0.5 -0.0 -1.1 0.9 -1.4 -0.7 -1.5 -0.9
Maternal smoking around birth 0.1 0.2 0.7 -0.2 0.0 -0.4 -0.6 -0.0 -0.0 -0.3 0.1 -0.8 -0.2 -0.3 -0.3 0.1 -0.7 -0.5 -0.4 -0.7 0.8 -0.0 -0.0 -0.5 -0.2 -0.3
Fed-up feelings 0.5 0.9 4.0 1.1 -0.1 0.2 0.3 1.2 1.0 2.0 1.5 -0.1 1.2 0.0 1.1 1.3 0.6 0.7 -1.0 -0.2 -0.5 1.5 0.6 0.4 0.8 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.7 1.1 -1.2 -0.6 0.9 0.6 0.8 1.0 1.2 1.0 -0.2 -1.3 -0.7 1.0 -0.7 0.6 -0.8 0.1 -0.2 1.1 -1.0 -0.7 -0.8 -1.1
Relative age voice broke 0.6 0.9 3.6 -1.7 0.9 0.8 -0.8 -1.4 -1.9 -1.2 -0.7 0.4 -0.2 0.6 -0.1 -1.5 0.7 -0.9 0.7 1.4 0.9 -0.5 0.7 -0.1 0.5 0.5
Taking other prescription medications 1.9 2.9 8.4 -1.5 -1.0 -2.1 -0.1 -0.1 -0.3 -2.1 -2.0 -2.6 -1.4 -0.6 -2.1 -0.6 -2.9 -1.6 -0.6 -2.2 0.2 -1.9 -2.3 -1.7 -2.4 -2.0
Age when periods started (menarche) 0.7 1.6 3.5 1.7 -1.2 -0.0 1.8 1.2 1.3 0.7 1.4 -0.3 -1.9 -1.4 -1.0 1.4 -0.4 0.7 -0.3 1.0 -1.3 1.6 -1.8 -1.5 -1.4 -1.2
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 3.7 1.8 0.2 1.1 0.3 1.7 1.2 1.4 1.9 1.9 -0.0 -0.7 1.6 1.4 0.8 1.4 -0.6 0.4 -1.8 1.9 0.1 0.8 0.5 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 4.1 0.3 -0.5 -1.4 -0.8 1.4 0.6 -0.4 -0.5 -1.5 -0.3 0.2 -0.7 0.4 -1.1 -0.7 -0.4 -2.0 -0.5 -0.5 -0.7 -0.6 -0.9 -0.8
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 2.3 -1.2 1.3 0.7 -0.3 -0.6 -1.5 -1.2 -0.9 1.0 -0.7 1.5 -0.5 -1.1 0.1 -1.0 0.5 0.9 1.2 -0.7 0.9 0.9 0.7 0.6
Qualifications: CSEs or equivalent 0.4 0.6 1.5 -1.2 -0.7 -0.9 -0.4 -0.6 -0.6 -0.5 -1.1 -0.4 -0.5 0.1 0.1 -0.7 -0.7 -0.8 -0.0 -1.2 -0.4 -1.1 -0.8 -1.1 -0.9 -0.8
Serious illness, injury or assault to yourself 1.2 1.4 4.5 1.4 -1.1 -0.6 0.7 1.6 1.5 0.9 1.1 -0.2 -0.4 -0.8 -0.6 1.7 -0.7 1.7 -1.6 -1.0 -2.1 1.3 -1.1 -1.3 -0.8 -1.1
High blood pressure 0.2 0.6 2.7 -0.4 -0.4 -0.2 -1.6 -0.6 -0.8 0.4 0.6 1.1 0.2 -0.6 1.1 -0.2 -0.6 -0.1 0.2 -0.5 -0.5 0.5 -0.7 -1.6 -0.8 -0.8
Hayfever, allergic rhinitis or eczema 4.8 10.5 55.2 -3.2 -1.4 -3.1 1.4 -0.3 -0.9 -5.3 -4.3 -7.4 -1.5 3.0 -6.4 -1.4 -1.6 -3.9 -2.3 -0.8 3.1 -4.3 0.0 0.3 -0.2 -3.0
Multivitamins +/- minerals 0.2 0.3 1.0 0.9 -0.3 -0.3 -0.6 0.9 1.0 1.0 0.5 -0.2 0.7 0.0 0.4 0.6 -0.4 0.2 0.2 -0.5 -0.3 0.7 0.4 0.3 0.3 -0.4
Stomach or abdominal pain in last month 0.6 0.8 2.4 0.8 0.8 0.5 -0.5 -0.4 0.1 0.8 0.9 1.6 0.1 0.5 0.9 0.0 1.1 -0.2 1.3 0.6 0.9 1.0 1.4 1.2 1.1 0.9
Supplements: Glucosamine 0.5 0.6 6.2 -0.8 0.3 -0.1 -2.5 -0.6 -0.8 -0.2 -0.3 1.3 -0.5 0.0 -0.6 -0.8 -0.8 -0.8 0.7 -0.2 0.4 -0.3 0.6 0.4 0.2 -0.2
Diverticular disease/diverticulitis (self-reported) 1.8 2.1 6.7 -0.9 -1.8 -1.9 1.1 0.7 0.5 -1.0 -1.0 -2.4 -1.6 -0.4 -1.5 0.5 -0.8 0.6 -2.4 -2.6 -1.8 -1.1 -1.2 -1.5 -1.0 -1.6
Medication: Atenolol 1.8 2.3 7.5 2.0 -0.5 0.1 1.7 1.9 1.8 2.7 2.1 1.2 0.9 -1.2 1.1 2.0 0.8 2.5 -1.4 0.4 -1.8 2.1 0.0 0.7 0.5 0.2
Medication: Levothyroxine sodium 0.9 1.6 8.1 -0.7 -1.5 -1.2 2.3 0.5 0.7 -0.9 -1.4 -2.7 -0.6 0.5 -2.8 0.1 -0.7 -0.6 -1.5 -1.1 0.3 -1.3 -0.4 -0.1 -0.1 -1.1
Sitting height 0.3 2.5 8.0 1.3 0.4 1.4 -0.2 -0.3 0.3 2.8 1.9 2.3 1.3 1.8 2.5 0.3 2.7 0.8 1.2 1.6 -0.1 2.1 1.7 1.0 1.6 1.3
Chronic bronchitis/emphysema (father) 0.3 0.4 3.2 0.4 -0.3 0.0 1.8 0.4 0.8 -0.4 -0.8 -0.9 0.1 -0.6 -0.5 0.2 -0.3 0.4 -0.3 -0.3 0.2 -0.8 0.2 0.7 0.5 -0.3
High blood pressure (mother) 0.2 0.3 0.7 0.4 -0.1 0.6 0.7 0.1 0.2 0.8 0.7 0.7 0.8 0.2 -0.4 0.3 0.4 0.7 -0.4 0.5 -0.5 0.7 -0.0 0.8 0.2 0.3
Body mass index (BMI) 0.3 1.4 6.9 1.0 -0.9 -1.4 1.1 1.4 2.1 1.8 0.1 0.3 -0.2 0.1 0.1 1.5 -0.6 1.1 -1.9 -2.6 -1.5 0.1 -0.4 -1.1 -0.2 -0.7
Impedance of leg (left) 0.2 0.8 4.2 -0.7 0.2 0.8 0.8 -0.3 -1.6 -2.0 0.2 -1.5 0.1 -1.1 -1.2 -0.3 -0.0 0.2 -0.1 2.0 0.8 0.2 -0.7 -0.1 -0.5 0.3
Leg predicted mass (left) 0.3 1.4 6.5 1.0 0.4 0.5 0.2 0.3 1.4 2.5 0.4 1.4 0.7 2.3 2.0 0.5 1.7 0.5 0.0 -0.9 -0.7 0.6 1.6 0.6 1.6 0.9
Trunk fat mass 0.3 1.2 4.4 0.8 -1.0 -1.2 1.0 1.4 1.7 1.2 0.1 0.1 -0.4 -0.3 -0.1 1.3 -0.7 1.1 -1.8 -2.1 -1.7 0.2 -0.8 -1.4 -0.5 -1.1
Waist circumference 0.4 1.5 5.3 1.1 -1.0 -0.8 1.7 1.5 1.9 2.0 0.6 0.1 0.4 0.2 0.2 1.7 0.0 1.6 -2.3 -1.9 -1.8 0.8 -0.4 -0.9 0.0 -0.6
Number of incorrect matches in round 0.4 0.7 2.4 -1.3 1.2 0.8 -1.5 -0.9 -0.8 -1.2 -1.0 0.1 -0.1 0.8 0.5 -1.1 -0.1 -1.1 0.4 -0.5 0.6 -1.1 0.6 -0.0 0.5 0.5
Past tobacco smoking 0.3 0.6 2.7 -0.0 0.8 0.7 -0.5 0.1 -0.2 -0.2 -0.4 0.5 0.9 0.1 0.6 -0.6 0.5 -0.8 1.1 1.0 1.0 -0.5 1.0 1.6 0.8 1.0
Alcohol usually taken with meals 0.4 0.6 2.9 0.5 0.6 1.0 -0.4 -0.5 -0.1 1.7 1.6 0.7 -0.6 -0.3 0.1 0.3 0.2 0.8 0.7 1.0 -0.3 1.5 0.2 -0.8 0.2 0.6
Nervous feelings 0.4 0.7 3.6 0.6 0.7 1.2 0.1 -0.3 0.2 1.3 1.3 1.3 0.8 -1.0 1.9 0.4 0.9 0.4 -0.1 0.4 -0.4 1.3 0.1 0.3 0.3 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 7.6 1.9 -0.2 0.3 0.4 0.8 0.6 1.6 2.7 0.1 1.3 -1.5 0.9 1.4 -0.4 0.3 0.0 0.7 -0.0 2.7 -0.6 -0.6 -0.6 -0.2
Hearing difficulty/problems with background noise 0.2 0.3 0.9 -0.6 0.5 0.6 -0.9 -0.8 -0.2 -0.8 -0.6 -0.2 -1.0 0.3 0.2 -0.5 -0.5 -0.5 0.1 -0.4 -0.4 -0.5 0.0 -0.8 0.1 -0.1
Hair/balding pattern: Pattern 2 0.1 0.2 0.9 -0.1 -0.1 0.2 -0.2 0.4 0.6 0.6 -0.0 1.0 0.3 0.3 -0.2 0.4 -0.1 0.3 -0.7 -0.8 -0.5 -0.0 -0.0 -0.5 0.2 -0.2
Had menopause 1.3 1.6 5.1 0.6 -1.2 -1.0 1.9 0.9 1.1 0.4 0.7 -1.6 -1.2 -0.9 -1.6 1.4 -0.2 1.5 -2.2 -0.2 -1.6 0.7 -1.4 -1.7 -0.9 -1.5
Had other major operations 1.0 1.2 3.6 0.7 -1.6 -1.9 1.2 1.1 1.2 0.9 0.5 -0.2 -0.8 -0.6 0.3 1.2 -0.7 1.3 -1.6 -1.3 -1.2 0.3 -1.3 -0.6 -1.1 -1.2
Forced vital capacity (FVC) 0.3 1.1 4.0 -0.6 0.4 0.9 0.0 -1.3 -1.4 0.8 0.3 1.2 0.2 2.0 -0.2 -1.1 1.7 -0.3 1.3 1.0 1.1 0.5 1.3 0.9 1.1 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 3.4 0.1 -0.7 -1.5 -0.7 1.4 0.8 -0.0 -0.6 -1.8 0.7 0.2 -0.1 0.4 -0.9 -0.4 -0.8 -1.8 0.1 -0.6 -0.2 -0.5 -0.4 -0.8
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 3.4 -0.6 1.8 1.6 -1.2 -1.2 -1.7 -0.8 0.3 1.3 0.1 0.4 0.6 -1.0 0.2 -0.6 1.3 1.8 0.7 0.2 0.2 -0.8 0.1 0.7
Qualifications: None of the above 0.5 1.0 3.9 1.5 0.2 1.1 1.2 0.5 0.5 0.8 1.5 0.1 0.8 -0.0 1.4 0.9 1.1 1.3 -0.2 2.0 0.2 1.4 0.4 1.1 0.8 0.8
Financial difficulties in last 2 years 0.4 0.5 2.8 -0.2 -0.3 -0.7 -0.1 0.1 0.4 0.1 -0.4 -0.6 -0.1 -0.3 0.2 0.1 -1.6 -0.9 -0.1 -1.7 0.3 -0.5 -0.7 -1.2 -0.9 -0.6
Mouth/teeth dental problems 1.4 2.1 7.2 -0.9 1.4 1.8 -1.0 -1.3 -0.9 0.4 -0.7 2.7 1.2 1.0 0.2 -1.2 2.2 0.2 1.0 1.3 1.1 -0.8 2.2 2.0 2.2 2.0
Heart attack 1.3 1.6 4.1 1.8 -0.0 0.7 0.9 1.0 1.4 1.9 1.8 1.8 1.5 -0.7 1.5 1.6 1.0 2.0 -1.0 0.6 -0.8 1.7 0.6 0.2 1.2 0.3
Allergy 5.0 11.5 48.9 3.8 0.8 2.9 -1.1 1.1 1.4 5.5 5.0 7.0 1.6 -2.8 6.7 2.0 1.9 4.3 1.8 0.7 -3.8 4.9 0.3 0.3 0.6 2.8
Pain all over the body in last month 0.1 0.2 0.8 -0.1 0.6 0.8 -0.6 -0.3 -0.4 -0.1 -0.0 0.7 -0.1 -0.2 0.9 -0.2 0.4 0.1 -0.2 0.2 -0.4 0.0 -0.2 -0.0 0.1 0.2
Diabetes (self-reported) 0.3 0.4 1.7 0.5 0.2 -0.2 -0.6 0.1 -0.2 -0.1 0.8 -0.3 -1.3 -1.1 -0.7 0.3 -0.9 -0.0 0.5 0.4 -0.3 0.8 -0.9 -1.0 -1.1 -0.4
Hayfever/allergic rhinitis (self-reported) 2.7 3.6 12.9 -2.1 -0.3 -0.9 1.1 -0.8 -0.9 -3.2 -2.9 -3.2 -0.3 2.7 -3.6 -1.3 0.2 -2.1 -0.8 0.6 2.7 -2.9 0.9 0.9 0.7 -0.8
Medication: Ramipril 0.5 0.6 6.0 0.3 0.8 0.5 -1.2 -0.4 -0.3 -0.1 0.3 2.4 0.6 -0.4 1.1 -0.3 -0.7 -0.4 1.4 0.6 0.2 0.3 -0.5 -0.4 -0.7 -0.0
Medication: Simvastatin 0.7 1.0 3.2 1.7 0.1 0.7 0.1 1.2 1.0 0.7 1.3 -0.2 1.5 -1.5 1.8 1.3 -0.5 1.0 -0.4 -0.2 -0.8 1.3 -0.7 -0.8 -0.3 0.5
Fluid intelligence score 0.5 1.0 3.2 1.1 0.0 1.3 0.5 0.8 0.6 1.2 1.8 0.7 1.3 1.1 0.7 1.1 1.0 0.8 -0.7 0.3 -0.1 1.6 1.1 0.1 1.4 0.7
Illnesses of siblings 0.1 0.2 0.9 0.4 0.1 -0.4 0.4 0.4 0.4 -0.1 -0.0 -0.4 -0.1 -0.4 0.2 -0.0 0.0 -0.5 1.0 0.8 0.8 -0.0 0.5 0.7 0.2 0.1
Neuroticism score 0.2 0.4 1.3 0.2 -0.4 0.2 0.1 0.3 0.5 1.0 0.9 0.0 0.2 -0.9 0.7 0.7 0.1 0.4 -1.2 -1.2 -1.1 0.9 -0.3 -0.7 0.0 -0.2
Weight 0.3 1.5 7.3 1.4 -0.4 -0.3 1.0 1.2 2.1 2.7 0.7 1.4 0.4 0.9 1.4 1.3 0.7 1.3 -1.1 -1.6 -1.4 0.8 0.6 -0.2 0.8 0.1
Impedance of arm (right) 0.3 1.5 7.8 -1.7 0.1 0.1 -0.5 -0.7 -1.9 -2.8 -1.3 -1.9 -0.6 -0.8 -1.5 -1.2 -1.0 -1.4 0.5 0.9 1.2 -1.2 -0.9 -0.6 -1.0 -0.6
Arm fat percentage (right) 0.3 1.2 7.4 0.1 -1.0 -1.7 0.6 1.2 1.3 0.6 -0.5 -0.7 -0.5 -0.3 -0.5 0.9 -1.3 0.4 -1.8 -2.7 -1.0 -0.5 -0.8 -1.6 -0.7 -1.2
Trunk fat-free mass 0.6 3.4 10.1 1.2 1.1 1.6 0.1 -0.0 1.2 3.2 0.9 2.7 1.6 3.0 3.0 0.3 3.0 0.8 0.6 0.0 -0.3 1.0 2.6 1.8 2.7 2.1
Hip circumference 0.2 0.7 3.6 0.6 -0.3 -0.8 0.3 0.9 1.6 1.9 -0.2 1.1 -0.2 0.6 0.7 0.7 -0.1 0.6 -0.9 -1.9 -1.0 -0.1 0.2 -0.5 0.2 -0.3
Time employed in main current job 0.3 0.4 0.8 -0.6 0.7 0.8 -0.7 -0.8 -0.8 -0.9 -0.3 0.8 -0.2 0.5 -0.8 -0.7 0.7 -0.5 0.7 0.5 0.0 -0.3 0.4 0.6 0.4 0.3
Alcohol intake versus 10 years previously 0.1 0.2 0.8 -0.1 0.4 0.4 0.1 -0.5 -0.1 0.1 -0.0 -0.1 0.6 0.7 -0.7 -0.2 0.4 -0.5 0.0 -0.0 0.6 0.1 0.5 0.9 0.6 0.3
Father’s age at death 0.3 0.4 1.4 -0.8 0.8 -0.2 -0.6 -0.3 -0.5 -1.2 -1.1 -0.6 -0.3 0.5 -0.6 -0.7 0.0 -0.8 0.2 -0.2 0.1 -1.1 0.6 0.7 0.4 -0.2
Worrier / anxious feelings 0.9 1.6 4.6 1.1 -1.7 -0.9 1.8 1.1 1.4 1.2 1.3 -2.0 -0.0 -1.1 -1.0 1.6 0.0 1.4 -2.1 -0.6 -1.4 1.4 -1.0 -0.9 -0.5 -1.1
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 5.2 0.9 1.1 2.3 1.1 -0.1 -0.1 1.1 1.5 -0.8 1.9 1.1 1.2 0.6 2.1 0.9 -0.2 0.9 0.2 1.6 1.0 0.7 1.6 2.1
Falls in the last year 0.2 0.3 1.6 -0.8 -0.1 0.3 -0.1 -0.9 -0.5 0.0 -0.5 -0.4 -0.5 0.9 -1.3 -0.6 0.4 -0.1 -0.3 -0.0 0.7 -0.6 0.0 -0.6 0.1 0.5
Hair/balding pattern: Pattern 3 0.3 0.4 2.4 0.2 -1.1 -1.1 0.2 0.3 0.5 0.0 0.1 -0.3 -0.6 0.1 -1.5 0.4 -0.3 0.0 -0.6 -0.4 -0.5 0.1 -0.5 -0.9 -0.6 -1.3
Number of live births 0.3 0.4 2.2 0.1 -0.1 0.6 1.0 0.1 0.5 0.3 -0.4 -0.9 -0.3 -0.2 0.3 0.1 0.5 0.7 -0.5 -0.3 -0.2 -0.4 1.0 1.5 1.3 0.7
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 4.1 0.4 -0.1 1.1 1.0 -0.3 -0.4 2.0 1.2 0.6 1.1 1.3 0.4 0.0 1.8 0.8 0.4 1.1 0.6 1.5 1.0 0.8 1.1 1.5
Pulse rate 0.6 1.1 2.8 -0.6 1.4 1.2 0.0 -1.6 -1.0 -0.7 -0.7 -0.4 0.3 1.0 -0.3 -1.0 1.7 -0.4 0.9 1.4 1.6 -0.6 1.1 0.5 1.1 1.6
Happiness 0.2 0.3 1.3 0.1 0.5 0.7 -0.3 -0.2 -0.9 -0.4 0.8 0.0 0.6 0.3 -0.3 0.0 -0.3 -0.2 0.1 1.0 1.1 0.9 0.3 -0.6 0.4 -0.2
Noisy workplace 1.2 1.5 4.7 -0.7 2.0 1.3 -1.2 -1.1 -1.2 -0.9 -0.6 2.0 0.7 0.9 0.8 -1.4 0.1 -1.6 2.2 0.7 1.7 -0.5 1.1 1.0 0.7 1.2
Qualifications: A levels/AS levels or equivalent 0.8 1.8 5.1 -2.3 0.6 -0.1 -1.0 -1.8 -1.9 -2.0 -1.8 0.1 -1.1 1.8 -1.9 -1.9 0.7 -1.0 1.0 0.5 0.9 -1.8 1.1 -0.1 0.7 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.0 0.3 -0.6 0.0 1.0 -0.0 0.6 0.6 0.3 0.7 -1.0 -0.4 -0.9 0.4 0.5 1.0 -0.5 0.6 -0.8 0.3 -0.0 0.5 0.3 -0.3
Mouth/teeth dental problems: Dentures 1.2 2.0 4.4 1.0 -1.6 -2.1 0.3 1.2 0.9 0.6 1.2 -1.6 -0.7 -1.2 -0.6 1.2 -1.8 0.2 -0.9 -1.9 -2.0 1.3 -1.9 -1.7 -2.1 -2.1
Asthma 1.8 3.6 11.5 -2.4 0.9 0.2 0.0 -1.4 -1.3 -3.3 -3.4 -2.3 0.5 1.9 -2.3 -1.9 -0.6 -2.6 0.2 0.1 3.3 -3.3 0.9 1.2 0.8 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.9 -0.5 -0.4 -0.2 0.9 -0.6 -0.3 -0.5 -0.5 0.4 -0.5 0.1 -0.5 -0.6 -0.5 -0.4 0.8 0.1 0.2 -0.5 -0.5 -0.6 -0.6 -0.3
Medication: Cholesterol lowering 0.2 0.4 1.8 0.5 -0.1 -0.4 -1.0 0.2 -0.1 0.6 0.7 1.3 -0.1 -1.3 0.9 0.3 -0.5 0.4 -0.0 0.1 -0.0 0.7 -0.6 -0.4 -0.6 -0.2
Depression (self-reported) 0.1 0.1 0.5 -0.2 0.4 -0.3 -0.4 -0.4 -0.2 -0.7 -0.5 -0.4 -0.0 0.4 0.4 -0.2 -0.4 -0.5 0.1 -0.6 0.2 -0.3 -0.1 -0.3 -0.2 -0.4
Medication: Lansoprazole 0.9 1.0 2.6 0.9 -0.5 -1.1 -0.8 1.2 0.9 0.8 1.1 -0.5 -0.7 -1.0 0.1 1.1 -1.6 0.3 -0.4 -1.5 -1.6 1.0 -1.0 -0.7 -1.1 -1.3
Prospective memory result 1.1 1.3 3.2 -0.8 -0.9 -1.8 -0.8 -0.5 -0.3 -1.5 -1.4 -0.8 -0.7 -0.8 -1.2 -0.5 -1.5 -0.6 0.0 -1.4 -0.9 -1.2 -1.4 -1.4 -1.8 -1.8
Lung cancer (father) 0.3 0.4 2.0 -0.1 -0.6 -0.8 0.5 0.5 0.6 0.2 -0.0 -1.4 -0.6 0.1 -0.1 0.3 -0.7 -0.1 -0.4 -0.5 0.2 -0.2 -1.0 -1.0 -1.0 -0.4
Illnesses of mother 0.2 0.2 1.2 0.3 -0.6 -1.1 -0.3 0.5 0.5 0.3 -0.1 0.4 -0.4 -0.7 0.2 0.1 -0.6 -0.6 0.5 -0.7 -0.0 -0.2 0.0 -0.4 -0.2 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 3.4 0.7 -0.4 0.6 0.2 0.2 0.0 1.8 1.1 0.4 0.4 0.2 0.5 0.2 0.5 0.5 0.6 0.4 -0.1 1.3 0.2 -0.2 0.2 0.7
Pulse wave Arterial Stiffness index 0.5 0.6 2.0 -0.0 -0.4 -1.1 -0.7 -0.0 0.1 -0.3 0.2 0.3 -1.1 -1.0 -0.1 0.2 -1.2 -0.3 -0.0 -1.0 -1.4 0.1 -1.0 -0.8 -1.2 -1.3
Impedance of arm (left) 0.3 1.6 8.0 -1.3 -0.5 -0.5 -0.4 -0.3 -1.4 -2.8 -1.2 -1.9 -1.0 -1.6 -1.9 -0.9 -1.5 -1.2 0.2 0.8 0.4 -1.2 -1.3 -0.6 -1.4 -1.3
Arm fat mass (right) 0.3 1.1 6.6 0.7 -0.8 -1.2 0.8 1.3 1.8 1.4 -0.2 0.1 -0.2 0.3 0.1 1.1 -0.5 0.8 -1.6 -2.6 -1.4 -0.1 -0.1 -0.9 0.0 -0.7
Trunk predicted mass 0.6 3.5 9.8 1.1 1.3 1.7 0.0 -0.1 1.1 3.1 0.8 2.8 1.6 3.1 3.0 0.2 3.0 0.8 0.7 0.1 -0.2 1.0 2.7 1.9 2.8 2.2
Standing height 0.4 3.8 11.3 1.4 1.2 2.7 0.0 -0.3 0.2 2.6 1.5 2.8 1.6 2.0 3.1 -0.0 3.4 0.9 1.6 2.2 -0.0 1.8 2.5 2.1 2.6 2.2
Length of working week for main job 0.4 0.4 2.1 -0.6 -0.3 -0.5 0.7 -0.6 -0.3 -0.6 -0.9 -1.4 0.3 1.0 -0.8 -0.5 0.5 -0.1 0.0 0.5 1.3 -0.8 0.3 0.7 0.3 0.1
Exposure to tobacco smoke at home 0.3 0.3 1.0 0.7 -0.3 -0.1 0.2 0.8 1.0 0.8 0.7 0.2 0.9 -0.5 0.7 0.8 0.1 0.8 -1.0 -0.3 -0.5 0.5 -0.0 0.3 0.3 0.0
Breastfed as a baby 0.6 0.7 4.4 0.5 0.7 1.0 -1.4 -0.2 -0.5 0.8 0.8 2.1 0.1 -0.6 0.9 -0.1 0.4 0.0 1.0 1.4 -0.6 0.9 0.2 0.7 0.0 0.1
Tense / ‘highly strung’ 0.3 0.5 1.6 0.7 -0.4 0.3 1.0 0.2 0.5 0.8 1.2 -0.3 0.1 -0.4 0.5 0.9 0.4 1.2 -1.1 0.9 -0.7 1.3 -0.5 -0.0 -0.1 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 2.5 -1.1 -0.4 -1.2 -0.1 -0.7 -0.7 -1.6 -1.5 0.5 -0.9 0.0 -1.5 -0.8 -1.0 -0.7 0.0 -0.6 -0.4 -1.3 -1.2 -1.3 -1.5 -1.2
Hair/balding pattern: Pattern 4 0.4 1.0 6.3 -0.2 0.2 -0.6 -0.2 -0.8 -0.4 -0.5 -0.1 1.9 -2.0 -2.5 -0.8 -0.6 -1.1 -0.9 1.1 0.2 0.6 -0.3 -0.9 -0.6 -1.3 -0.8
Birth weight of first child 1.7 3.2 15.4 -0.6 2.6 1.6 -2.6 -1.4 -1.1 -1.0 -1.1 3.9 0.0 0.9 1.8 -1.8 0.4 -2.4 3.3 1.1 1.6 -1.0 1.6 1.4 0.9 1.4
Peak expiratory flow (PEF) 1.5 3.5 11.9 1.3 0.5 2.0 1.6 0.3 0.5 2.9 2.0 1.7 3.5 1.6 1.4 0.8 3.1 1.9 -0.3 1.7 0.1 2.2 1.8 2.2 2.2 2.2
Pulse wave reflection index 0.5 0.6 1.8 0.8 -0.3 -0.4 -0.3 0.8 0.8 1.3 1.2 1.2 0.5 0.1 0.8 1.0 -0.0 0.4 -0.6 -0.9 -1.3 1.2 0.1 -0.2 0.1 -0.7
Ever highly irritable/argumentative for 2 days 1.1 1.3 3.4 0.3 1.5 1.7 -0.8 -0.4 -1.1 0.3 1.3 0.7 1.8 0.6 1.2 -0.5 0.6 -0.6 1.8 1.1 1.6 1.1 1.5 0.9 1.3 1.5
Loud music exposure frequency 0.9 1.0 3.3 -1.1 -0.1 -0.9 -0.9 -0.2 -0.6 -1.1 -0.7 -1.3 -1.3 -0.8 -0.6 -0.7 -1.4 -1.8 0.1 -0.9 0.8 -0.8 -1.1 -1.4 -1.3 -1.0
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 3.7 -1.9 -0.1 -0.8 -0.5 -1.0 -1.0 -1.1 -1.5 -0.4 -1.2 0.9 -1.9 -1.1 -0.3 -0.7 -0.3 -0.8 0.1 -1.4 -0.2 -0.9 -0.4 -0.4
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.5 0.0 0.1 -0.2 -0.0 -0.1 -0.2 -0.5 -0.2 0.2 0.1 -0.1 0.5 -0.2 -0.6 -0.6 0.6 -0.0 0.7 -0.2 -0.0 -0.5 -0.2 -0.2
Blood clot in the leg (DVT) 1.9 2.4 9.2 -0.3 -1.2 -2.9 -0.2 0.6 0.7 -0.2 -0.5 -1.4 -1.8 -0.7 -1.3 0.5 -2.0 -0.2 -1.3 -2.1 -1.2 -0.5 -2.0 -3.0 -2.3 -2.6
Medication: Paracetamol 0.3 0.5 4.4 0.3 0.3 -0.2 -0.2 0.6 0.2 -0.0 -0.0 1.1 -0.6 -0.4 2.1 0.0 -1.3 -0.4 0.7 -1.0 -0.5 -0.1 -0.3 -0.2 -0.6 -0.3
Headache pain in last month 0.4 0.8 2.4 -0.9 0.9 0.6 -0.7 -1.0 -1.0 0.7 -0.2 0.7 -0.2 1.1 1.5 -0.8 0.5 -0.5 0.8 0.3 1.5 -0.2 1.4 0.7 1.1 0.9
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 5.0 -0.1 -0.3 0.4 1.8 0.3 0.3 -0.4 -0.6 -1.7 0.4 2.2 -1.1 0.1 1.3 0.0 -0.4 0.3 0.1 -0.4 0.9 0.5 1.0 0.5
Glaucoma (self-reported) 0.4 0.5 2.2 -0.8 0.0 0.0 0.5 -0.7 -0.4 -1.2 -1.5 -0.8 -0.4 1.0 -1.1 -0.8 -0.1 -0.7 0.2 -0.4 -0.3 -1.4 -0.4 -0.1 -0.3 0.0
Gout (self-reported) 0.5 0.7 2.6 -0.2 1.3 0.6 -1.6 -0.5 -0.7 0.6 0.3 1.1 1.2 0.6 1.5 -0.6 0.0 -0.5 1.4 0.0 0.5 0.3 0.7 0.4 0.3 0.9
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 9.4 -1.1 -1.2 -1.7 1.1 0.4 0.2 -1.5 -1.5 -3.1 -0.8 -0.3 -1.8 -0.2 -1.9 -1.5 -0.9 -1.9 0.2 -1.5 -1.3 -1.0 -1.4 -1.4
Medication: Amlodipine 0.6 0.8 3.0 0.4 0.8 0.7 -1.0 -1.1 -0.7 0.5 1.1 1.7 -0.7 -1.5 -0.1 -0.3 -0.3 -0.1 1.4 1.4 0.0 1.0 -0.7 -0.5 -0.9 0.1
Medication: Ventolin 100micrograms inhaler 2.0 2.6 11.1 -2.0 -0.2 -0.3 -0.6 -0.8 -0.8 -2.8 -2.6 -2.2 -1.1 1.4 -3.3 -1.2 -1.2 -2.3 -0.5 -1.4 1.3 -2.6 -0.4 -0.2 -0.2 -0.4
Birth weight 1.1 2.5 14.7 1.3 1.3 1.7 -1.0 0.5 1.3 1.8 0.9 0.3 1.4 0.5 3.8 0.8 2.1 0.7 -0.2 0.3 -0.5 1.1 2.5 1.8 2.8 1.3
Chronic bronchitis/emphysema (mother) 0.7 0.8 3.4 -1.3 0.5 -0.5 -0.7 -0.7 -0.4 -0.9 -1.5 -1.1 -0.5 1.8 -0.3 -0.6 0.5 0.0 -1.0 -0.7 0.8 -1.5 1.2 0.2 1.1 0.3
High blood pressure (siblings) 0.6 0.8 3.7 0.3 -0.7 0.2 -0.4 0.3 0.3 1.1 1.1 0.4 0.3 -0.3 0.4 0.9 -0.4 1.0 -1.5 -1.3 -1.9 1.1 -1.0 -1.3 -0.6 -0.6
Forced vital capacity (FVC), Best measure 0.1 0.4 2.0 -0.5 0.0 0.4 -0.7 -0.9 -1.1 0.5 0.0 0.5 -0.6 0.9 -0.4 -1.0 0.5 -0.8 1.4 0.5 0.8 0.2 0.5 0.1 0.1 0.6
Body fat percentage 0.4 1.8 5.6 0.4 -1.1 -1.8 1.2 1.4 1.4 0.4 -0.2 -0.8 -0.8 -0.9 -1.0 1.3 -1.5 0.9 -2.2 -2.4 -1.6 -0.1 -1.4 -2.0 -1.1 -1.6
Leg fat percentage (right) 0.3 1.1 5.5 0.5 -0.6 -0.9 2.1 1.2 1.3 0.8 -0.0 -1.0 0.3 0.2 -0.6 1.3 -0.3 1.4 -2.4 -1.6 -1.1 0.1 -0.6 -1.1 -0.2 -0.4
Arm fat-free mass (right) 0.6 2.8 11.3 1.7 0.5 1.2 1.1 0.5 1.7 3.4 1.3 2.1 1.3 2.3 2.3 1.0 2.7 1.6 -0.2 -0.0 -1.0 1.5 1.9 1.2 2.1 1.6
Exposure to tobacco smoke outside home 0.2 0.3 1.9 0.6 0.1 -0.2 0.3 -0.2 0.5 1.2 0.3 0.3 0.6 0.4 1.4 0.2 0.8 0.3 0.3 -0.0 0.1 0.4 0.1 0.1 0.1 0.5
Comparative body size at age 10 0.5 1.3 3.8 1.0 -1.9 -1.7 0.7 1.7 1.9 1.2 -0.0 0.2 0.4 -0.4 -0.1 1.5 -0.5 1.2 -2.0 -1.4 -1.3 0.1 -0.3 -0.1 -0.0 -1.6
Number of full brothers 0.6 0.7 1.8 0.9 -0.4 -0.2 1.3 1.4 1.3 0.7 0.6 -0.1 0.0 -1.3 0.4 1.2 -0.6 1.1 -1.2 -0.1 -1.2 0.4 -0.8 0.1 -0.5 -0.6
Worry too long after embarrassment 0.3 0.4 2.4 0.2 0.1 1.5 0.4 -0.5 0.1 0.7 1.0 -1.0 0.3 -0.0 0.1 0.5 1.0 0.4 -0.7 -0.1 -0.5 1.0 0.2 -0.3 0.8 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 5.4 -0.1 -0.2 -1.5 -1.3 0.5 0.3 -1.1 -0.8 0.8 -2.3 -1.5 0.3 -0.2 -2.3 -1.3 0.6 -1.3 -0.6 -0.8 -1.4 -1.8 -1.9 -1.7
Wheeze or whistling in the chest in last year 0.4 0.8 3.2 -0.8 0.7 0.7 -0.3 -0.5 -0.2 -1.2 -1.1 -1.7 -0.0 1.4 -0.9 -0.6 0.0 -1.2 0.1 -0.5 1.8 -1.2 0.4 0.1 0.5 0.6
Number of children fathered 1.6 1.8 7.6 0.2 1.4 1.7 -1.1 -0.7 -0.3 0.9 0.4 1.5 1.7 0.2 1.8 -0.4 1.9 0.2 1.0 1.3 0.5 0.4 2.2 2.8 2.1 1.3
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 4.4 1.6 0.5 1.5 0.2 1.0 0.9 1.6 2.1 0.1 1.5 -0.4 0.5 1.2 0.9 0.9 0.0 0.9 -0.6 2.0 1.2 1.1 1.5 0.7
Age at first live birth 0.6 1.1 10.9 -0.5 0.3 0.0 -1.3 -0.8 -0.9 -0.7 -0.5 3.3 -0.7 -1.3 0.1 -1.0 -1.0 -0.9 1.8 0.8 0.3 -0.5 -0.7 0.1 -1.2 -0.1
Pulse wave peak to peak time 0.4 0.5 1.2 0.2 0.1 0.9 0.8 0.3 0.2 0.5 -0.0 -0.3 1.0 0.7 0.2 0.0 1.1 0.5 -0.2 1.0 1.1 0.0 0.8 0.7 1.0 1.0
Health satisfaction 0.7 1.0 3.6 -0.5 0.4 -0.2 -0.7 -0.2 -0.7 -1.1 -1.0 1.0 -1.3 -1.3 0.1 -0.7 -1.9 -1.0 1.0 -0.1 0.4 -0.7 -1.5 -1.4 -1.7 -0.6
Shortness of breath walking on level ground 1.0 1.2 3.4 -1.3 1.3 1.3 -1.1 -1.6 -1.1 -1.0 -1.6 1.9 -0.8 0.9 0.1 -1.5 0.7 -0.7 1.2 0.7 1.0 -1.4 0.8 0.5 0.7 1.0
Qualifications: College or University degree 0.2 0.6 3.3 -1.0 0.3 -0.1 -0.6 -0.8 -0.6 -0.8 -1.0 0.6 -0.9 -0.3 -1.8 -0.9 -1.0 -0.7 0.7 0.3 0.6 -1.1 -0.2 -0.3 -0.4 -0.3
Eye problems/disorders: None of the above 1.1 1.3 4.1 -1.1 0.3 -1.2 -1.3 -0.6 -0.8 -1.8 -1.2 -1.3 -0.6 -0.0 -0.5 -1.3 -1.5 -2.0 1.6 -1.0 0.6 -1.4 -0.4 -0.8 -1.1 -0.8
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 0.1 0.1 0.4 0.5 -0.3 -0.2 -0.2 0.1 0.3 0.4 -0.1 -0.5 -0.0 0.3 -0.2 0.2 0.4 0.4 0.2 0.2 -0.1 0.3 0.2
Emphysema/chronic bronchitis 0.8 0.9 3.2 -1.2 0.1 -0.5 -0.8 -0.6 0.0 -1.2 -1.7 -1.7 -1.3 0.6 -1.8 -0.6 0.0 -0.4 -0.7 -0.8 -0.4 -1.6 0.4 0.2 0.4 -0.3
Medication for pain relief, constipation, heartburn 0.7 1.3 3.7 -0.9 1.1 0.8 -0.8 -1.1 -1.3 -0.9 -0.8 -0.9 1.4 1.3 -0.5 -1.1 1.5 -0.9 0.8 1.3 1.9 -0.7 1.4 1.0 1.2 1.3
Neck or shoulder pain in last month 0.5 0.7 3.5 0.3 0.2 0.8 0.7 0.0 -0.1 1.5 1.3 -1.9 1.0 0.6 0.6 0.5 0.7 0.9 -0.6 -0.4 0.5 1.3 0.5 -0.2 0.6 1.4
Medication: Blood pressure 1.0 1.8 6.6 0.3 -1.0 -1.5 -1.3 0.2 0.4 0.6 0.8 1.6 -0.9 -2.6 0.4 0.6 -2.0 0.5 -0.6 -1.0 -1.4 0.7 -2.1 -1.8 -2.2 -1.9
Angina (self-reported) 0.6 0.8 2.3 1.5 -0.5 -0.2 0.3 1.3 0.7 0.8 1.5 1.1 0.5 -1.0 -0.2 1.2 -0.5 0.8 -0.2 0.2 -1.4 1.5 -0.8 -0.4 -0.7 -0.7
Migraine (self-reported) 1.2 1.5 5.7 1.1 1.3 1.8 -0.3 0.0 0.2 1.2 1.3 2.4 1.7 -0.4 2.2 0.3 0.6 0.8 1.2 1.2 0.8 1.2 0.9 0.9 0.9 1.7
Medication: Ibuprofen 0.2 0.3 1.0 -0.6 0.1 0.3 0.4 -0.9 -0.8 -0.6 -0.3 0.3 -0.1 0.5 -0.3 -0.8 -0.1 -0.6 1.0 0.2 0.6 -0.3 -0.0 -0.6 -0.1 0.2
Medication: Allopurinol 0.5 0.6 2.8 -0.6 1.3 0.4 -1.7 -0.5 -0.7 -0.4 -0.8 0.6 1.1 0.2 1.3 -0.7 -0.4 -0.8 0.9 -0.1 0.7 -0.8 0.6 0.5 0.3 0.7
Medication: Omeprazole 0.4 0.5 3.2 0.5 0.7 0.7 -0.7 -0.3 -0.1 0.9 0.9 1.0 0.0 -0.3 1.8 -0.0 -0.2 -0.4 0.9 -0.0 0.3 0.8 -0.4 -0.9 -0.5 0.7
Medication: Seretide 50 evohaler 1.3 1.5 11.4 -1.4 0.3 0.5 0.2 -0.9 -1.3 -1.9 -1.2 -1.5 -0.4 1.6 -3.4 -0.9 0.3 -0.9 -0.5 0.9 1.7 -1.1 0.4 0.3 0.6 0.0
Mean time to correctly identify matches 0.3 0.5 2.0 1.1 -0.5 0.4 0.7 1.2 0.9 0.5 0.5 0.3 0.5 -1.4 0.7 1.1 -0.4 1.4 -0.8 -0.1 -0.5 0.5 -0.4 -0.2 -0.0 0.1
Heart disease (mother) 0.1 0.1 0.6 -0.5 0.6 0.5 -0.8 -0.3 -0.4 -0.6 -0.2 0.0 -0.1 0.6 -0.2 -0.1 0.1 -0.2 -0.4 -0.4 0.4 -0.3 -0.0 -0.2 0.1 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 2.2 1.3 -0.1 0.5 0.9 0.7 1.3 0.8 1.0 0.8 1.5 0.2 1.1 0.9 0.2 0.2 0.2 0.9 -0.7 0.9 -0.3 0.8 0.0 0.0
Whole body fat mass 0.3 1.2 4.7 0.7 -0.9 -1.2 1.1 1.2 1.6 1.3 0.0 -0.1 -0.3 0.1 -0.1 1.3 -0.6 1.1 -1.8 -2.2 -1.6 0.2 -0.6 -1.4 -0.3 -0.9
Leg fat mass (right) 0.2 0.8 3.2 0.7 -0.3 -0.7 1.4 0.9 1.4 1.5 0.1 -0.1 0.2 0.7 0.3 1.1 0.2 1.2 -1.8 -1.7 -1.0 0.3 0.0 -0.9 0.3 -0.1
Arm predicted mass (right) 0.6 3.2 12.3 2.1 0.4 1.2 1.5 0.9 2.1 3.5 1.5 1.9 1.5 2.2 2.4 1.3 2.7 1.9 -0.4 -0.1 -1.1 1.6 1.9 1.3 2.2 1.6
Pulse rate, automated reading 0.2 0.8 2.8 -0.3 0.8 1.2 0.8 -1.4 -0.8 0.1 0.2 -0.6 0.1 1.2 0.1 -0.4 1.7 0.0 0.5 1.6 1.5 0.3 0.6 0.0 0.8 1.4
Alcohol intake frequency. 0.9 2.0 5.9 -2.0 0.9 -0.1 -1.5 -1.8 -1.4 -1.9 -2.4 0.9 -1.6 1.6 -0.1 -2.0 -0.6 -1.9 1.3 -0.1 2.0 -2.2 0.4 -0.0 -0.0 0.4
Comparative height size at age 10 0.5 2.7 7.8 1.3 1.1 2.5 -0.3 -0.2 0.6 1.9 1.3 2.8 1.0 1.5 2.3 0.4 2.6 0.7 0.5 1.8 -0.1 1.4 2.4 1.4 2.8 1.5
Number of full sisters 1.5 1.8 5.1 -0.7 1.8 1.0 -1.4 -1.3 -1.2 -0.3 -0.4 0.8 1.0 2.0 0.1 -1.3 1.6 -1.0 1.7 0.7 2.1 -0.5 2.3 1.7 1.8 1.5
Suffer from ‘nerves’ 0.4 0.6 3.2 -1.0 0.5 0.7 0.9 -1.2 -0.8 0.2 -0.3 -1.6 -0.5 1.8 -0.3 -0.6 1.1 0.1 -0.6 0.4 0.4 -0.1 0.3 -0.4 0.5 0.8
Overall health rating 0.4 0.8 4.1 -0.7 0.2 -0.5 -0.7 -0.8 -0.8 -1.3 -0.6 0.2 -2.0 -0.5 -0.5 -0.7 -0.8 -1.1 0.5 -0.3 -0.4 -0.5 -1.4 -1.4 -1.6 -0.7
Chest pain or discomfort 0.1 0.1 0.5 0.2 0.3 0.3 -0.3 0.0 0.2 0.1 0.2 0.7 -0.2 0.6 0.0 0.1 0.7 -0.3 -0.0 0.1 -0.1 0.2 0.3 0.2 0.5 -0.1
Had major operations 0.4 0.5 2.7 -0.3 0.3 -0.1 -1.6 -0.1 -0.3 0.2 -0.2 1.2 0.1 -0.2 0.3 -0.6 -0.7 -1.5 1.0 -0.4 1.2 -0.2 0.3 0.4 -0.1 0.2
Age at last live birth 0.4 0.6 1.8 -0.5 -0.6 -0.7 -0.6 -0.1 -0.1 -0.9 -1.2 1.0 -0.7 -1.0 -0.8 -0.7 -1.1 -0.7 0.6 -0.5 -0.0 -1.3 -0.7 0.3 -1.0 -0.6
Family relationship satisfaction 1.0 1.2 6.9 -1.2 1.1 0.6 -0.8 -1.0 -1.7 -1.6 -1.0 0.1 -0.5 2.6 -0.1 -1.2 0.4 -0.9 0.7 1.0 1.5 -0.8 0.5 -0.7 0.4 0.7
Leg pain on walking 0.8 1.0 2.7 1.2 -0.8 -0.4 0.5 1.1 1.3 0.3 0.6 1.5 -0.7 -1.2 -0.1 1.1 -1.5 0.5 -0.5 -0.2 -1.5 0.7 -1.1 -1.3 -1.0 -1.6
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 4.3 -1.3 -0.8 -1.1 0.3 -0.3 -0.1 -0.8 -1.6 -2.1 -0.9 0.6 -1.6 -0.3 -0.3 -0.2 -1.2 -1.7 0.1 -1.4 -0.1 0.0 -0.0 -0.4
Commuting to job workplace: Car/motor vehicle 1.1 1.3 5.9 1.5 0.7 1.3 0.5 0.6 0.5 1.4 1.8 2.4 0.1 -1.4 1.6 0.6 0.7 1.0 1.3 1.2 0.1 1.5 0.3 0.8 0.3 1.2
Illness, injury, bereavement, stress in last 2 years 1.1 1.4 4.3 0.4 1.7 1.4 -0.9 -0.4 -0.7 0.3 0.9 2.1 1.6 0.4 1.6 -0.4 1.2 -0.3 1.7 1.6 1.1 0.8 1.2 1.0 1.1 1.4
Medication: Aspirin 0.9 1.2 3.3 1.8 -0.5 0.1 -0.0 1.5 1.7 1.6 1.6 1.1 -0.1 -0.7 0.0 1.8 -0.3 1.6 -1.2 -0.2 -1.5 1.6 -0.2 0.2 0.3 -0.5
Supplements: Vitamin C 0.7 0.8 2.4 0.2 -0.7 -0.8 -1.3 0.2 -0.2 -0.1 0.3 0.0 -1.3 -0.9 -0.8 -0.2 -1.4 -1.1 1.3 -0.5 -0.2 0.3 -1.1 -1.5 -1.5 -1.1
Knee pain experienced in last month 0.2 0.4 1.9 -0.5 -0.0 -0.4 -0.7 -1.1 -0.9 0.8 0.7 0.8 -0.4 0.2 -0.2 -0.2 -0.4 0.3 -0.2 -0.5 0.1 0.8 0.0 -1.4 -0.2 -0.1
Hypertension (Self-reported) 0.2 0.6 2.2 0.3 -0.5 -0.2 -1.1 -0.1 -0.3 1.1 1.1 1.1 0.5 -0.9 1.5 0.3 -0.5 0.3 0.0 -0.5 -0.7 1.1 -0.7 -1.4 -0.7 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 4.6 0.7 0.9 0.9 -0.4 0.0 0.5 1.6 0.9 1.1 1.7 0.7 2.1 0.6 0.8 0.5 -0.2 -0.5 -0.6 1.0 1.0 0.1 1.1 0.9
Illnesses of father: Heart disease 0.5 0.7 4.2 0.1 1.1 1.2 -1.1 -0.4 -0.4 0.2 0.2 2.0 -0.0 -0.2 1.9 -0.4 0.5 -0.2 0.9 -0.1 0.5 0.2 0.1 0.4 0.0 1.1
Illnesses of siblings: Diabetes 0.3 0.4 1.5 -0.6 0.4 0.1 -0.0 -0.4 -0.2 -0.9 -1.2 -0.5 -0.3 0.9 -1.1 -0.5 0.2 -0.9 -0.1 -0.5 0.7 -1.2 0.4 0.1 0.4 0.2
Smoking status: Previous 0.5 0.8 2.7 -0.2 -1.1 -1.3 -0.0 0.1 0.4 -0.0 0.0 -0.7 -0.6 -0.3 -0.4 0.5 -0.9 0.6 -1.4 -1.5 -1.0 0.2 -1.2 -1.6 -1.0 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 3.4 -0.1 1.3 1.7 -0.7 -0.9 -0.7 0.3 -0.3 0.8 0.6 1.6 1.1 -0.8 1.6 -0.4 1.6 0.8 1.2 -0.2 1.6 1.2 1.5 1.8
Whole body fat-free mass 0.5 2.9 10.2 1.3 0.9 1.3 0.1 0.2 1.3 3.2 0.9 2.5 1.4 2.8 2.9 0.4 2.7 0.9 0.5 -0.3 -0.5 1.1 2.4 1.4 2.4 1.8
Leg fat-free mass (right) 0.3 1.6 8.1 1.2 0.3 0.4 -0.2 0.4 1.4 2.8 0.8 1.8 0.6 2.0 2.3 0.6 1.4 0.5 0.3 -0.9 -0.8 1.0 1.5 0.4 1.5 0.8
Arm fat percentage (left) 0.4 1.6 7.7 0.3 -1.2 -2.0 0.7 1.3 1.6 0.5 -0.5 -0.7 -0.8 -0.8 -0.7 1.1 -1.7 0.5 -1.8 -2.8 -1.3 -0.5 -1.1 -1.7 -1.0 -1.6
Average weekly red wine intake 0.7 1.0 3.0 0.2 1.5 1.7 -1.1 -1.0 -0.9 0.5 0.9 0.4 0.9 0.8 1.2 -0.5 0.7 -0.0 1.6 0.9 0.7 0.8 1.3 0.4 1.2 1.7
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.7 0.1 -0.2 -0.0 -0.8 0.2 -0.3 0.3 0.7 -0.0 -0.4 0.8 0.5 0.0 0.8 0.1 0.2 0.2 0.5 0.5 0.7 -0.2 0.7 0.6
Mood swings 0.5 0.8 2.6 1.1 -0.1 0.4 -0.1 1.1 0.6 1.4 1.5 1.0 1.0 -0.6 1.6 1.1 0.7 0.8 -0.6 -0.1 -0.6 1.5 0.6 0.6 0.8 0.4
Loneliness, isolation 0.5 0.6 2.3 -0.9 -0.4 -0.9 -0.7 -0.7 -0.7 -0.8 -0.4 0.4 -1.5 -0.5 -0.2 -0.6 -1.1 -1.0 0.2 -0.3 0.1 -0.3 -0.8 -1.2 -1.1 -1.2
Long-standing illness, disability or infirmity 0.9 1.4 4.4 -1.1 -0.8 -1.3 0.1 0.0 -0.3 -1.6 -1.2 -1.1 -1.4 -0.4 -2.1 -0.3 -1.9 -1.0 -0.7 -1.1 0.2 -1.2 -1.6 -1.5 -1.7 -1.6
Ever had bowel cancer screening 0.4 0.4 3.4 0.4 -0.3 -0.2 -0.5 -0.1 0.1 -0.7 -0.4 1.9 -0.1 -0.6 0.2 -0.1 -0.9 0.0 0.5 -0.3 -0.7 -0.4 -0.9 -0.7 -1.0 -0.6
Diabetes diagnosed by doctor 0.3 0.4 1.5 1.0 0.5 0.5 -0.2 0.4 0.2 0.4 1.2 0.8 -1.0 -0.9 -0.7 0.6 -0.4 0.4 0.4 1.0 -0.4 1.2 -0.5 -0.3 -0.5 0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.9 -1.3 1.0 0.8 -1.4 -1.0 -1.1 -0.4 -1.2 0.6 0.3 0.2 1.4 -1.3 0.4 -0.7 1.0 0.2 0.6 -1.0 0.2 0.3 0.0 0.9
Friendships satisfaction 0.3 0.3 2.6 0.4 -0.1 0.3 0.1 0.2 -0.1 0.3 0.7 1.6 0.7 0.7 0.9 0.3 -0.1 -0.0 0.0 0.7 0.7 0.9 0.2 -0.4 0.2 -0.0
Qualifications: nursing, teaching 3.0 4.7 12.5 -3.5 1.8 0.8 -2.2 -3.5 -3.2 -2.7 -3.1 1.0 -1.4 1.9 -1.5 -3.4 0.6 -2.3 2.0 0.3 2.3 -3.0 0.8 -0.1 0.3 1.2
Commuting to job workplace: Walk 0.5 0.5 2.2 -1.3 -0.1 -0.4 0.2 -0.7 -0.3 -0.9 -1.5 -0.6 -0.5 0.9 -0.9 -0.8 -0.4 -0.7 -0.4 -0.4 0.1 -1.5 -0.1 0.1 -0.0 -0.3
Eye problems/disorders: Cataract 1.3 1.5 5.2 1.7 -1.0 0.3 2.0 1.4 1.8 1.9 1.1 1.0 0.2 -1.3 0.8 1.7 0.6 2.3 -1.5 0.7 -1.0 1.3 -0.4 0.4 0.3 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 12.5 -0.6 -0.5 -0.8 1.5 0.6 0.4 -0.9 -0.9 -3.5 -1.2 1.2 -1.1 0.2 -0.8 -0.1 -1.6 -0.7 0.3 -0.9 -0.7 -1.2 -0.5 -0.6
Medication for cholesterol 0.4 0.6 1.9 -0.6 0.5 -0.7 -1.1 0.0 -0.2 -0.8 -0.8 0.9 -1.3 -0.5 -0.2 -0.6 -1.2 -1.4 0.9 -0.4 1.1 -0.9 0.4 0.4 -0.1 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 2.7 -0.2 -1.2 -0.9 -0.5 -0.0 -0.1 0.1 0.3 -0.5 -1.5 -1.6 0.7 0.2 -0.4 0.0 -0.5 -0.5 -1.1 0.2 -1.0 -0.4 -1.0 -1.1
Back pain experienced in last month 0.6 0.9 3.0 0.5 -0.8 0.1 1.5 0.5 0.5 1.7 1.5 -0.1 -0.8 -0.1 -0.4 1.1 0.5 1.3 -1.3 -0.5 -1.0 1.6 -0.6 -1.1 -0.3 -0.0
Mineral and other dietary supplements 0.5 0.7 5.5 1.0 -0.2 -0.2 2.3 1.0 1.2 1.0 0.5 -0.5 0.5 0.1 0.9 1.1 0.7 0.8 -1.0 -0.1 -0.4 0.5 -0.1 0.4 0.1 0.3
Breast cancer (self-reported) 0.3 0.3 1.8 -0.5 0.1 -0.2 -0.3 -0.0 0.1 -0.7 -0.9 -1.3 0.1 0.7 0.3 -0.1 0.4 0.1 -0.9 -0.5 0.3 -0.9 0.6 0.9 0.8 -0.1
Asthma (self-reported) 1.6 3.2 10.4 -2.3 0.8 0.3 0.3 -1.4 -1.2 -3.0 -3.1 -2.4 0.9 2.0 -2.3 -1.7 -0.4 -2.3 -0.1 0.2 3.2 -3.0 0.8 1.1 0.8 0.4
Osteoporosis (self-reported) 0.5 0.6 2.5 -0.2 0.7 0.7 0.9 -0.5 -0.1 0.1 -0.8 -1.1 0.5 0.1 0.7 -0.4 1.3 0.5 0.0 1.0 0.6 -0.8 0.2 1.6 0.4 1.2
Osteoarthritis (self-reported) 0.7 0.9 3.2 0.8 -1.2 -0.7 1.8 0.8 0.7 1.2 1.4 -0.8 0.0 -0.9 -0.3 1.2 -0.4 1.4 -1.4 0.1 -0.5 1.3 -0.8 -0.4 -0.6 -0.5
Medication: Aspirin 0.9 1.2 3.5 1.9 -0.1 0.5 -0.4 1.4 1.6 1.7 1.8 1.2 0.3 -0.8 0.3 1.7 -0.0 1.4 -0.9 -0.1 -1.3 1.7 0.3 0.7 0.7 -0.2
Medication: Gliclazide 2.1 2.4 7.0 2.6 -0.1 0.4 1.0 2.2 2.2 2.3 2.3 0.5 1.6 -1.8 2.1 2.1 0.2 1.6 -0.7 0.3 -1.0 2.2 0.1 1.4 0.5 0.4
Illnesses of father: None of the above (group 1) 2.0 2.5 12.0 -1.8 -1.0 -2.0 -0.1 -0.7 -0.8 -2.2 -2.1 -3.5 -1.6 1.2 -2.7 -0.8 -1.1 -1.0 -0.7 -1.1 0.2 -2.1 -1.0 -1.8 -1.2 -1.2
Smoking status: Current 0.6 1.0 3.1 1.5 0.9 0.9 1.3 0.8 0.9 1.2 1.0 1.2 0.4 0.5 0.2 0.8 1.3 0.5 0.5 0.6 -0.4 1.1 1.1 1.8 1.2 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.8 5.9 1.1 -2.4 -1.0 0.8 1.3 1.2 1.3 1.1 -1.5 0.2 -2.1 -0.3 1.4 -1.3 1.6 -1.7 -1.1 -1.3 1.1 -1.4 -1.6 -1.1 -1.2
Whole body water mass 0.5 2.8 10.4 1.4 0.8 1.2 0.3 0.3 1.5 3.2 0.9 2.5 1.4 2.7 2.8 0.5 2.5 0.9 0.4 -0.3 -0.6 1.1 2.2 1.4 2.3 1.6
Leg predicted mass (right) 0.3 1.5 7.7 1.2 0.3 0.4 -0.2 0.4 1.4 2.8 0.8 1.8 0.6 2.0 2.2 0.6 1.4 0.5 0.3 -0.9 -0.7 0.9 1.5 0.4 1.5 0.7
Arm fat mass (left) 0.2 1.0 5.6 0.7 -0.7 -1.1 0.7 1.2 1.7 1.3 -0.1 0.4 -0.4 0.2 -0.0 1.1 -0.5 0.8 -1.5 -2.4 -1.3 -0.1 -0.2 -0.9 -0.0 -0.7
Number of self-reported non-cancer illnesses 0.2 0.3 2.3 -0.1 0.7 0.5 -0.5 0.2 0.2 -0.3 -0.1 -0.2 1.5 0.5 0.6 0.3 0.2 -0.4 -0.8 -0.2 0.4 -0.1 0.7 0.5 0.8 -0.1
Average weekly champagne plus white wine intake 0.8 1.1 5.3 1.0 -1.4 -0.8 0.4 1.0 1.5 0.4 0.2 0.0 -1.4 -2.3 -0.6 0.9 -1.6 0.2 -0.4 -0.6 -0.9 0.0 -1.3 -1.3 -1.2 -1.4
Miserableness 0.5 0.9 2.8 -0.3 1.5 0.8 -1.6 -0.7 -0.7 0.5 0.0 1.6 0.9 0.4 1.7 -0.7 0.3 -0.9 1.4 -0.4 0.6 0.1 1.3 0.4 0.9 1.0
Guilty feelings 0.4 0.6 3.3 0.6 0.3 1.1 -0.4 -0.2 -0.2 0.5 1.4 -0.2 1.2 -0.6 1.8 0.4 0.5 0.4 -0.1 -0.3 -0.5 1.3 0.7 0.2 0.9 0.6
Wears glasses or contact lenses 0.4 0.5 1.6 -1.2 0.6 0.7 -0.6 -1.1 -0.9 -0.6 -0.5 1.3 0.4 0.4 -0.1 -0.7 1.2 0.0 -0.2 -0.1 -0.2 -0.6 1.0 -0.1 1.1 0.5
Ever taken oral contraceptive pill 0.7 0.8 4.7 -1.2 0.5 -0.7 -2.2 -0.4 -0.8 -1.0 -1.4 0.4 -0.6 0.4 -0.5 -0.9 -1.2 -0.6 0.3 -1.0 0.4 -1.3 1.0 0.2 0.5 -0.2
Hearing aid user 0.8 0.9 3.6 -1.1 0.4 0.2 -1.4 -1.4 -0.5 -1.5 -1.9 1.5 -1.1 -0.1 -1.2 -1.0 -0.4 -0.7 0.4 -0.4 0.2 -1.7 -0.1 0.4 0.0 0.1
Mother’s age at death 1.1 1.3 4.5 0.9 -1.1 -0.4 1.6 1.3 1.4 1.2 0.6 0.1 -0.7 -2.1 0.4 1.3 -0.9 1.5 -1.5 -0.4 -2.1 0.7 -1.3 -0.1 -0.8 -1.1
Financial situation satisfaction 0.5 0.6 1.9 -0.2 -0.1 -0.8 0.8 -0.0 -0.0 -0.7 -0.6 -0.9 -0.9 0.5 -0.8 -0.4 -1.2 -0.9 0.5 0.5 0.9 -0.7 -1.0 -1.4 -1.3 -0.9
Tinnitus: Yes, now most or all of the time 0.6 0.8 4.4 0.1 0.8 0.7 -1.5 -0.3 -0.3 -0.2 -0.0 1.5 1.1 0.1 0.9 -0.3 0.2 -0.7 0.6 -0.0 0.5 0.0 1.3 2.1 1.2 0.7
Commuting to job workplace: Public transport 1.2 1.4 5.5 -0.1 -1.8 -1.1 1.6 0.5 0.3 0.1 0.1 -2.1 -0.1 0.2 -0.4 0.9 -0.9 1.3 -2.3 -0.4 -1.3 0.3 -1.8 -2.0 -1.3 -1.3
Eye problems/disorders: Glaucoma 0.3 0.4 2.7 -0.8 0.6 0.5 0.1 -0.8 -0.4 -0.2 -0.9 -0.5 0.4 1.6 0.0 -0.7 1.0 -0.2 -0.0 -0.0 -0.2 -0.8 0.4 0.5 0.5 0.7
Medication: Blood pressure 0.4 0.8 2.8 1.0 -0.4 1.0 0.9 0.5 0.7 1.4 1.2 -0.1 0.9 -0.3 0.9 1.0 1.1 1.7 -1.1 0.2 -1.4 1.1 -0.2 -0.5 0.4 0.4
Pain type(s) experienced in last month: Hip pain 0.6 0.8 2.1 0.5 -1.2 -0.8 0.6 0.5 0.3 0.3 0.4 1.1 -1.4 -0.9 -0.3 0.4 -0.8 0.5 -0.2 -0.3 -1.2 0.5 -1.4 -1.4 -1.4 -0.8
Supplements: Fish oil (including cod liver oil) 1.0 1.3 4.6 -1.3 1.1 1.3 -2.1 -1.4 -1.4 -0.8 -0.9 1.8 0.0 1.0 -0.7 -1.5 0.5 -0.8 1.1 0.9 1.1 -0.9 1.2 0.8 1.1 0.8
High cholesterol (Self-reported) 1.6 2.9 8.8 2.0 0.9 1.8 0.4 1.4 0.9 2.3 2.5 -0.1 2.9 -0.4 3.0 1.8 1.6 2.1 -0.9 0.6 -1.1 2.6 0.7 1.2 1.3 1.7
Medication: Bendroflumethiazide 0.1 0.2 1.1 0.2 -0.4 -0.1 0.2 0.1 0.4 0.6 0.3 0.0 -0.3 -0.5 0.4 0.3 -0.4 0.2 -0.4 -0.7 -1.1 0.1 -0.2 -0.2 -0.1 -0.5
Medication: Paracetamol 0.3 0.5 4.9 -0.0 0.6 0.3 -0.4 0.1 -0.5 0.1 0.3 0.9 -0.5 0.2 2.2 -0.3 -1.0 -0.7 1.2 -0.4 -0.1 0.3 -0.1 -0.1 -0.4 0.2
Medication: Lisinopril 1.5 2.0 6.7 -0.1 -1.9 -1.7 0.7 0.4 0.6 -0.5 -0.2 -0.7 -1.5 -1.5 -0.9 0.6 -1.6 0.5 -1.7 -0.8 -1.6 -0.2 -2.3 -2.6 -2.2 -2.5
Medication: Atorvastatin 1.5 1.8 6.5 0.5 1.4 1.4 -0.3 -0.1 0.2 1.5 0.9 0.9 1.6 2.0 1.0 0.5 2.1 1.1 -0.4 1.5 0.5 1.0 2.3 1.7 2.5 1.1
Illnesses of father: High blood pressure 0.7 0.8 4.2 0.8 -0.2 0.3 0.4 0.8 0.8 1.5 1.2 2.0 1.9 0.1 1.1 0.9 0.2 0.7 -0.8 -0.1 -0.9 1.2 -0.1 0.4 0.1 -0.3
Alcohol drinker status: Never 0.3 0.3 1.2 -0.9 -0.4 0.2 0.3 -0.0 -0.5 -1.0 -0.6 -0.1 -0.1 1.1 -0.8 -0.1 0.7 -0.1 -1.0 0.0 -0.2 -0.6 0.4 0.4 0.7 0.1
Ever smoked 0.5 0.8 2.5 0.8 -0.9 -0.3 1.6 0.5 0.8 0.8 1.0 -1.0 -0.7 -0.1 -0.8 1.1 0.2 1.3 -1.3 -0.8 -1.2 1.1 -0.5 -0.9 -0.1 -0.6
Basal metabolic rate 0.4 2.3 9.2 1.3 0.6 0.9 0.3 0.4 1.5 3.0 0.8 2.1 1.1 2.4 2.5 0.6 2.2 0.9 0.1 -0.7 -0.8 0.9 1.9 1.1 2.0 1.3
Leg fat percentage (left) 0.4 1.6 6.2 0.8 -1.0 -1.4 1.8 1.5 1.5 1.2 0.5 -0.8 -0.1 -0.2 -0.4 1.6 -0.8 1.6 -2.5 -1.9 -1.5 0.6 -1.0 -1.7 -0.6 -0.9
Arm fat-free mass (left) 0.6 2.9 10.0 1.4 0.9 1.4 0.7 0.3 1.3 3.2 1.1 2.2 1.4 2.8 2.5 0.7 2.7 1.2 -0.0 -0.2 -0.5 1.2 2.3 1.4 2.5 1.9
Number of operations (self-reported) 0.2 0.3 1.3 0.9 -0.1 0.2 0.5 0.7 0.7 1.0 0.6 0.4 0.1 0.3 1.1 0.7 0.3 0.3 -0.3 -0.6 -0.3 0.5 0.2 0.4 0.3 0.5
Average weekly beer plus cider intake 0.8 1.2 3.5 -0.5 -1.5 -1.7 0.5 0.7 0.2 -1.5 -1.0 -1.9 -0.8 -0.4 -0.9 0.2 -0.8 0.1 -1.4 -1.3 -0.6 -1.0 -1.4 -1.1 -1.3 -1.4
Irritability 0.3 0.4 1.6 0.4 -0.3 -0.0 -0.1 0.3 0.3 1.2 1.3 1.2 0.5 -1.2 0.7 0.6 -0.3 0.7 -0.2 -0.5 -0.8 1.1 -0.3 -0.1 -0.2 -0.3
Risk taking 1.1 1.5 5.5 0.9 -1.6 -0.8 2.3 1.0 0.9 0.0 0.3 -0.5 -0.8 -1.5 -2.0 1.0 -1.3 0.9 -0.8 0.1 -1.0 0.3 -2.2 -1.1 -1.9 -1.4
Ever had prostate specific antigen (PSA) test 0.5 0.6 2.6 0.4 0.2 -0.2 -1.3 1.1 0.6 0.1 0.2 0.9 0.5 -1.2 -0.2 0.4 -1.6 -0.4 -0.1 -1.6 -1.4 0.0 -0.3 0.5 -0.3 -0.6
Fractured/broken bones in last 5 years 0.5 0.6 2.6 -0.1 0.8 1.5 0.4 -0.6 -0.1 0.9 0.4 1.3 0.9 0.4 0.8 -0.2 1.4 0.8 0.0 0.6 0.2 0.5 0.6 0.3 0.8 1.6
Age started oral contraceptive pill 0.5 0.7 3.0 -0.0 -0.4 0.3 1.6 -0.0 0.8 0.5 -0.2 -0.2 -0.8 1.1 -1.0 0.6 0.9 1.5 -1.7 0.1 -1.0 -0.1 0.4 -0.2 0.9 0.1
Diastolic blood pressure, automated reading 0.1 0.4 1.3 0.5 0.3 1.1 0.1 -0.5 -0.2 0.5 1.0 1.0 0.0 -0.3 0.7 0.1 0.8 0.1 0.6 0.9 -0.1 1.0 0.4 -0.0 0.5 0.5
Ever depressed for a whole week 3.7 4.5 11.1 -2.4 3.0 2.8 -1.0 -3.1 -3.3 -2.1 -1.4 2.3 0.5 2.9 0.5 -2.7 1.6 -1.2 2.0 2.5 2.2 -1.3 1.7 0.9 1.5 2.3
Unable to work because of sickness or disability 0.2 0.3 2.4 0.7 0.1 0.1 0.6 0.5 0.3 -0.2 0.6 -0.5 -0.8 -0.0 -1.5 0.6 -0.4 0.4 -0.2 0.5 0.0 0.5 0.0 0.2 0.1 -0.2
Commuting to job workplace: Cycle 0.4 0.4 1.9 0.4 -0.9 -0.7 0.7 0.4 0.6 0.3 0.1 -1.4 1.3 1.0 -0.5 0.5 0.2 0.5 -0.8 0.7 0.5 0.1 0.3 0.2 0.5 -0.5
Myopia 0.4 0.5 2.7 -0.8 0.9 0.5 -0.4 -0.5 -0.8 -1.6 -0.9 -0.0 -0.9 -0.6 -1.0 -0.8 -0.6 -0.7 0.8 -0.0 0.5 -1.1 0.1 -0.4 -0.0 0.3
Vascular/heart problems diagnosed by doctor 0.2 0.7 2.9 0.0 0.1 -0.1 1.6 0.5 0.7 -0.7 -1.0 -1.7 -0.2 1.1 -1.2 0.0 0.6 -0.0 -0.3 0.2 0.7 -0.9 0.6 1.4 0.7 0.7
Cholesterol lowering medication 1.7 2.6 6.2 2.5 0.3 1.9 1.5 1.6 1.7 1.8 2.2 -0.6 2.3 -0.9 2.2 2.0 1.2 2.4 -1.0 0.7 -1.9 2.2 -0.2 0.3 0.6 1.2
Medication: Omeprazole (e.g. Zanprol) 0.5 0.7 2.2 1.1 -0.3 0.3 -0.0 0.5 0.7 1.3 1.5 0.8 0.0 -0.5 1.3 1.0 -0.3 0.5 -0.4 -0.5 -0.8 1.4 -0.7 -1.2 -0.5 -0.1
Pain experienced in last month 1.1 1.8 8.5 -1.2 0.3 -0.8 -0.9 -0.4 -0.3 -2.9 -2.9 -1.3 -0.4 -0.2 -1.4 -1.4 -1.0 -1.9 0.9 -0.0 0.7 -2.8 -0.3 0.5 -0.5 -0.8
Supplements: Calcium 1.3 1.4 3.7 -1.8 0.9 0.5 -1.9 -1.5 -1.9 -1.2 -1.9 1.1 0.4 1.1 0.4 -1.8 -0.2 -1.1 1.2 -0.3 1.2 -1.6 0.6 0.2 0.2 0.8
Basal cell carcinoma (self-reported) 1.0 1.2 3.6 1.9 -0.1 0.2 0.1 1.5 1.1 1.4 1.9 1.1 0.4 -1.5 0.7 1.5 -0.4 1.3 -0.2 -0.8 -1.7 1.8 -0.5 -0.2 -0.4 0.3
Heart attack/myocardial infarction (self-reported) 1.3 1.7 4.3 1.9 -0.2 0.6 1.1 1.2 1.6 2.0 1.9 1.7 1.4 -0.8 1.3 1.8 1.0 2.1 -1.1 0.4 -1.0 1.8 0.5 0.1 1.0 0.1
Deep venous thrombosis (DVT) (self-reported) 2.2 2.8 9.8 0.0 -1.6 -3.0 0.0 1.0 1.0 0.3 -0.1 -1.7 -1.7 -0.9 -1.0 0.9 -2.1 0.2 -1.8 -2.2 -1.7 -0.1 -2.2 -3.1 -2.4 -2.8
Heart disease (siblings) 0.3 0.4 1.7 -1.1 0.2 -0.4 -1.0 -0.6 -0.4 -0.6 -1.1 -0.2 -0.5 -0.3 0.1 -0.5 -0.7 -0.1 -0.5 -1.3 -0.4 -1.1 -0.4 -0.4 -0.5 -0.3
Alcohol drinker status: Previous 1.5 1.7 4.6 -1.3 1.6 1.0 -1.6 -2.0 -2.1 -1.8 -1.0 0.3 -0.2 1.2 0.0 -1.8 -0.0 -1.5 1.9 1.3 2.1 -1.0 0.9 -0.0 0.5 0.9
Pack years of smoking 1.6 2.4 6.0 -2.0 1.8 0.9 -1.3 -2.5 -2.3 -1.9 -1.9 0.9 -0.4 1.3 -0.5 -2.4 0.4 -2.1 2.1 0.6 1.9 -2.0 0.9 0.5 0.4 1.2
Impedance of whole body 0.3 1.3 7.1 -1.2 -0.3 -0.0 0.3 -0.3 -1.6 -2.7 -0.7 -2.0 -0.5 -1.6 -1.7 -0.7 -1.0 -0.6 0.0 1.4 0.7 -0.6 -1.3 -0.6 -1.3 -0.8
Leg fat mass (left) 0.2 1.0 3.3 0.7 -0.5 -0.9 1.3 1.0 1.4 1.6 0.3 -0.1 -0.0 0.5 0.3 1.3 -0.1 1.3 -1.8 -1.8 -1.2 0.4 -0.2 -1.2 0.1 -0.4
Arm predicted mass (left) 0.6 2.9 9.7 1.1 0.9 1.3 0.7 0.1 1.2 3.1 0.9 2.1 1.3 3.0 2.4 0.6 2.9 1.3 -0.1 -0.3 -0.5 1.1 2.4 1.6 2.6 2.0