Hub : Genes

SKP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1180	0.0330	1.9e-05	0.072	0.044	0.085	0.081	0.091	4.4e-09	4.3e-06	1.6e-10	4.0e-10	3.6e-11
2	METSIM	Adipose	0.0885	0.0281	2.1e-04	-0.002	0.011	0.011	0.005	-0.001	8.4e-01	8.1e-03	7.3e-03	5.0e-02	5.6e-01
3	YFS	Blood	0.0296	0.0114	9.4e-04	0.022	0.007	0.029	0.022	0.025	5.9e-08	1.8e-03	4.9e-10	6.7e-08	8.5e-09
4	TCGA	Breast Invasive Carcinoma	0.0181	0.0098	1.6e-03	0.004	0.006	-0.001	NA	0.002	3.9e-02	1.9e-02	9.8e-01	NA	1.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.1	2.2	0.7	-1.5	-1.3	0.1
Bipolar Disorder or Schizophrenia	0.7	1.6	3.0	-0.7	-1.4	-1.7	-1.0
Depressed Affect (Nagel 2018)	1.1	2.4	6.7	-2.6	-0.9	0.3	-1.3
Depression (Nagel 2018)	1.0	1.5	2.1	-1.4	-1.4	0.6	-1.3
Intelligence (Savage-Jansen 2018)	0.6	1.7	3.1	-1.8	0.8	1.7	0.2
Neuroticism (Nagel 2018)	0.7	1.7	3.8	-1.9	-0.3	0.3	-1.6
Schizophrenia (2018)	0.7	1.4	2.0	-1.4	-0.6	-1.2	-1.4
Schizophrenia vs Biploar Disorder	0.2	0.3	0.8	0.2	0.9	0.3	-0.3
Worry (Nagel 2018)	0.5	1.1	2.5	-1.2	0.3	0.6	-1.6
Alzheimer’s Disease (in mother)	0.4	0.5	1.1	-0.0	-0.3	-0.8	-1.0
Alzheimer’s Disease (in father)	2.4	2.6	6.0	2.5	-0.4	-1.2	1.6
Alzheimer’s Disease (including proxy)	0.6	0.8	2.1	1.4	-0.2	-1.1	0.2
Crohns Disease (2017)	0.1	0.2	0.5	0.3	0.4	0.2	-0.7
Irritable Bowel Disease (IBD)	0.5	1.2	2.6	1.6	1.1	-0.9	0.6
Ulcerative Colitis (UC)	1.2	2.2	5.1	2.2	0.9	-1.1	1.3
Major Depression (MDD)	0.5	0.6	1.2	-0.9	0.2	1.1	-0.5
Reaction Time	0.6	1.2	3.1	0.7	-0.9	-1.8	0.4
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.0	-1.3	1.7	0.5	0.8
Breast Cancer	0.5	1.3	3.0	-1.7	-1.2	-0.2	-0.8
Ovarian Cancer	1.0	1.3	4.8	0.2	-2.2	-0.4	0.2
Prostate Cancer	0.6	0.8	1.6	-1.2	0.2	0.2	-1.3
Age at First Birth	0.4	0.6	0.8	-0.2	-0.9	-0.8	-0.9
Bipolar Disorder (2011)	0.9	0.9	2.0	-0.4	-1.4	1.1	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	2.4	-0.4	-0.7	0.6	1.6
Coronary Artery Disease (CAD)	0.3	0.4	1.3	-0.3	1.1	0.0	-0.2
Crohns Disease (2012)	0.6	1.0	2.4	0.1	-0.8	-1.5	-1.0
Mean Putamen Volume	0.6	0.7	1.6	-0.1	1.1	1.3	0.3
Fasting Glucose	0.8	1.0	2.8	1.7	0.9	-0.5	0.0
HbA1C	0.1	0.1	0.5	-0.0	0.2	-0.7	0.3
HDL Cholesterol	0.8	1.3	2.8	0.7	-1.2	-1.7	-0.5
LDL Cholesterol	0.3	0.4	1.6	0.4	-0.1	-1.3	-0.1
Lupus	0.4	0.5	0.9	-0.1	0.9	0.7	0.9
Neuroticism (2016)	0.9	1.3	2.0	-1.0	-0.9	1.3	-1.4
Primary Biliary Cirrhosis	1.0	1.5	2.9	-0.8	1.4	1.7	-0.4
Rheumatoid Arthritis	0.4	0.6	1.5	0.4	-0.8	-1.2	0.3
Schizophrenia (2014)	0.4	0.8	1.8	-0.5	-0.8	-0.8	-1.3
Triglycerides	0.1	0.1	0.3	0.3	-0.2	0.5	-0.4
Type 2 Diabetes (T2D) (2012)	2.2	2.6	3.7	-1.8	-1.8	-0.1	-1.9
Ulcerative Colitis	0.4	0.6	1.0	1.0	0.6	-0.7	0.8
Blood Eosinophil Count	1.5	11.6	38.1	-1.9	1.6	6.2	-1.5
Blood Platelet Count	0.1	1.0	2.5	-0.9	-0.7	0.4	-1.6
Blood Red Count	0.7	6.6	12.3	2.7	-1.6	-3.5	2.0
Blood White Count	0.1	0.4	1.0	-0.6	-0.0	-1.0	-0.7
Heel T-Score	0.1	1.1	1.6	-1.2	1.2	0.1	-1.1
BMI	0.5	2.8	8.1	-1.3	0.9	2.8	-0.9
Height	0.4	7.5	13.3	2.9	1.1	-3.6	2.6
Waist Hip Ratio (WHR)	0.4	1.7	4.0	1.6	-2.0	0.2	-0.4
Systolic Blood Pressure	0.6	3.2	7.2	-1.5	-2.7	-1.3	-1.2
Smoking Status	0.3	0.8	1.5	0.9	-1.2	-0.6	0.6
Allergy or Eczema	2.0	5.4	15.4	-2.1	0.8	3.9	-1.0
Cardiovascular Disease	0.6	1.8	3.4	-0.9	-1.4	-1.0	-1.8
Hypothyroidism (self reported)	0.9	2.0	3.5	-1.1	1.8	1.9	-0.3
Respiratory disease	0.7	1.6	4.3	-1.3	0.5	2.1	-0.5
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.0	-0.1	-0.7	0.9	-1.7
Lung FEV1/FVC ratio	0.2	0.8	2.5	-0.1	0.8	-0.2	-1.6
Lung FVC	0.2	1.0	1.6	-0.1	-1.3	1.3	-1.0
Neuroticism	1.5	3.5	6.7	-2.6	0.0	1.1	-2.5
Chronotype (morning person)	0.8	1.9	5.7	-1.0	0.2	1.0	-2.4
Hair Pigment	0.1	1.5	4.0	0.2	-2.0	-1.4	0.1
Tanning	0.1	1.4	2.8	0.5	-1.7	-0.7	-1.4
Hand grip strength (left)	0.4	0.9	1.9	1.4	-0.5	-0.6	1.1
Number of treatments/medications taken	4.0	7.1	13.9	-3.6	-0.5	1.3	-3.7
Average weekly spirits intake	0.2	0.3	0.6	-0.7	-0.2	-0.2	-0.8
Sensitivity / hurt feelings	0.9	1.5	4.0	-2.0	-0.2	0.2	-1.4
Frequency of depressed mood in last 2 weeks	0.5	0.8	2.2	-0.8	-1.5	0.4	-0.4
Hearing difficulty/problems: Yes	1.5	2.3	4.3	-1.0	1.8	2.1	0.8
Relative age of first facial hair	0.3	0.7	2.3	1.5	-0.3	-0.4	0.3
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	7.4	-1.3	0.9	2.7	-1.3
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.8	-1.1	-0.8	-0.8	-1.3
Ever had hysterectomy (womb removed)	1.0	1.1	1.8	-0.6	-1.0	-1.4	1.1
Systolic blood pressure, automated reading	1.4	3.9	9.1	-3.0	-1.5	0.6	-2.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.0	-0.7	-0.3	-0.5
Angina	1.4	1.8	4.9	-0.9	-1.1	0.2	-2.2
Medication for hormone replacement therapy	0.3	0.3	1.1	0.2	-1.0	0.1	-0.1
Vitamin and mineral supplements	0.9	1.2	3.3	0.1	-1.2	1.8	0.3
Supplements: Zinc	0.3	0.3	1.0	0.4	0.1	-1.0	-0.2
Medication: Co-codamol	1.1	1.2	2.7	-0.9	1.6	1.0	0.7
Medication: Metformin	0.9	1.2	2.3	-0.9	0.3	1.3	-1.5
Diabetes (father)	1.4	1.7	4.5	-0.6	-1.4	-2.1	-0.3
Diabetes (mother)	0.7	0.9	1.8	-1.1	-1.4	-0.7	-0.6
Severe depression (siblings)	0.3	0.3	1.0	0.3	0.4	0.1	1.0
Pack years adult smoking proportion	0.5	0.8	2.7	-1.6	-0.5	0.0	-0.2
Impedance of leg (right)	0.3	1.4	4.5	0.4	-0.9	-2.1	-0.4
Leg fat-free mass (left)	0.2	0.8	1.3	-0.1	0.9	1.2	1.0
Trunk fat percentage	0.7	2.9	4.9	-2.2	0.1	2.0	-1.6
Hand grip strength (right)	0.3	0.8	1.6	1.3	-0.4	-0.2	1.2
Townsend deprivation index at recruitment	0.8	1.1	2.6	-0.7	-0.4	1.6	-1.1
Current tobacco smoking	0.2	0.4	0.9	0.9	-0.4	-0.6	0.4
Average weekly fortified wine intake	0.4	0.5	1.2	0.5	-1.1	-0.8	-0.0
Maternal smoking around birth	0.3	0.5	1.6	0.2	-1.3	-0.1	-0.6
Fed-up feelings	0.2	0.4	0.6	-0.8	-0.5	0.4	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.4	-1.5	-0.5	0.6	-0.1
Relative age voice broke	0.5	0.8	1.4	1.0	-0.1	-0.9	1.2
Taking other prescription medications	4.1	6.3	11.0	-2.9	0.1	2.4	-3.3
Age when periods started (menarche)	1.2	2.8	5.1	1.1	1.6	-1.5	2.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	-0.4	-0.8	-1.1	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.4	-0.9	0.1	0.1	-1.2
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	6.0	-1.8	-2.5	-0.7	0.5
Qualifications: CSEs or equivalent	1.7	2.3	3.4	0.1	-1.7	-1.9	1.7
Serious illness, injury or assault to yourself	3.3	4.0	7.9	-2.8	-1.4	0.6	-2.4
High blood pressure	1.2	3.3	8.4	-1.7	-1.1	-0.8	-2.9
Hayfever, allergic rhinitis or eczema	1.3	2.7	9.2	-1.0	0.4	3.0	-0.7
Multivitamins +/- minerals	0.5	0.7	1.8	-0.7	0.6	-1.4	0.2
Stomach or abdominal pain in last month	1.3	1.7	5.2	-2.3	-0.6	0.3	-1.0
Supplements: Glucosamine	0.7	0.9	2.0	-0.7	-0.5	1.0	-1.4
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	7.1	0.0	-2.7	-0.8	0.1
Medication: Atenolol	0.8	1.0	1.8	-1.3	-1.1	-0.8	-0.6
Medication: Levothyroxine sodium	2.0	3.4	4.4	-1.7	1.8	2.1	-1.6
Sitting height	0.2	1.3	2.8	1.0	0.8	-0.9	1.7
Chronic bronchitis/emphysema (father)	0.9	1.1	2.5	1.1	-0.4	-1.6	0.7
High blood pressure (mother)	0.1	0.2	0.4	-0.1	-0.6	-0.6	-0.1
Body mass index (BMI)	1.1	4.5	10.4	-2.5	-0.1	3.2	-1.2
Impedance of leg (left)	0.4	1.8	4.6	0.6	-1.5	-2.1	-0.0
Leg predicted mass (left)	0.2	0.8	1.4	-0.1	0.9	1.2	1.0
Trunk fat mass	0.4	1.8	3.1	-1.7	0.1	1.8	-1.0
Waist circumference	0.5	1.8	3.5	-1.4	-0.7	1.9	-1.2
Number of incorrect matches in round	0.2	0.4	0.7	0.0	-0.8	0.8	-0.2
Past tobacco smoking	0.3	0.5	0.8	0.4	0.9	-0.6	0.9
Alcohol usually taken with meals	0.9	1.4	4.4	-1.0	2.1	0.3	-0.3
Nervous feelings	0.3	0.5	1.0	-1.0	0.5	0.6	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	5.8	-2.4	-0.9	1.4	-1.7
Hearing difficulty/problems with background noise	0.3	0.5	1.1	0.1	1.1	0.9	-0.1
Hair/balding pattern: Pattern 2	0.6	0.7	1.1	-1.1	-0.9	-0.1	-1.0
Had menopause	0.3	0.4	1.1	-0.5	-0.4	-0.0	-1.0
Had other major operations	0.6	0.7	1.9	-1.4	-0.2	-0.2	0.9
Forced vital capacity (FVC)	0.1	0.4	0.9	1.0	-0.7	-0.4	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.3	-0.2	-1.1	-1.1	-0.8
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	5.2	-2.3	-0.5	-0.7	-1.4
Qualifications: None of the above	0.4	1.0	1.8	0.9	-1.3	0.0	1.1
Financial difficulties in last 2 years	0.5	0.7	2.3	-0.1	-0.8	1.5	0.0
Mouth/teeth dental problems	0.8	1.2	3.1	0.7	1.8	-0.7	0.8
Heart attack	0.2	0.3	0.8	-0.1	-0.9	-0.1	-0.5
Allergy	1.8	4.2	10.9	2.1	-0.6	-3.3	1.1
Pain all over the body in last month	0.5	0.6	0.9	0.7	-0.8	0.5	0.9
Diabetes (self-reported)	0.4	0.6	2.2	-0.0	-0.5	0.1	-1.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.6	-0.7	0.2	1.3	-0.1
Medication: Ramipril	1.3	1.6	3.5	-1.9	-1.3	-0.4	-1.1
Medication: Simvastatin	0.4	0.6	1.2	0.8	-0.7	-0.1	-1.1
Fluid intelligence score	0.7	1.4	4.0	-2.0	1.2	-0.0	0.6
Illnesses of siblings	0.4	0.6	1.3	0.9	-0.3	0.1	1.1
Neuroticism score	0.9	1.9	5.5	-2.4	-0.3	0.5	-1.4
Weight	0.3	1.3	3.8	-1.1	0.2	1.9	-0.1
Impedance of arm (right)	0.3	1.4	3.4	0.8	1.2	-1.9	-0.2
Arm fat percentage (right)	0.9	3.7	6.0	-2.4	0.3	2.4	-1.7
Trunk fat-free mass	0.1	0.6	2.3	0.4	0.1	0.2	1.5
Hip circumference	0.6	2.6	5.6	-2.4	0.6	2.0	-0.6
Time employed in main current job	0.3	0.4	0.8	-0.5	-0.5	-0.5	-0.9
Alcohol intake versus 10 years previously	0.4	0.5	1.3	-0.7	-0.2	1.2	-0.5
Father’s age at death	0.1	0.1	0.3	0.6	0.3	-0.0	0.2
Worrier / anxious feelings	0.3	0.6	1.8	-0.7	0.2	-0.1	-1.3
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.4	-1.4	-0.9	1.2	-1.6
Falls in the last year	2.0	2.6	5.3	-2.3	1.8	1.3	-0.3
Hair/balding pattern: Pattern 3	0.9	1.3	4.1	0.6	0.8	0.5	2.0
Number of live births	0.6	0.9	2.1	-0.4	-1.4	-0.5	-1.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.1	1.0	0.2	0.2	0.3
Pulse rate	0.0	0.1	0.2	-0.4	0.1	0.0	-0.4
Happiness	0.3	0.4	0.9	-0.2	0.0	0.9	-0.7
Noisy workplace	0.2	0.2	0.7	0.0	-0.8	-0.2	-0.5
Qualifications: A levels/AS levels or equivalent	1.4	3.0	7.7	-1.8	-0.8	-0.7	-2.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.0	-0.9	1.4	-0.4	1.1
Mouth/teeth dental problems: Dentures	0.5	0.9	1.7	-0.5	-1.3	1.1	-0.7
Asthma	0.3	0.5	1.2	-0.5	0.6	1.1	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.3	-0.1	1.1	1.1	-0.1
Medication: Cholesterol lowering	0.5	0.7	2.2	-0.3	0.3	0.8	-1.5
Depression (self-reported)	0.5	0.6	2.2	-1.5	0.3	0.2	-0.2
Medication: Lansoprazole	0.4	0.5	0.7	-0.8	0.3	0.8	-0.6
Prospective memory result	0.4	0.4	1.5	-0.4	-0.1	1.2	-0.3
Lung cancer (father)	1.8	2.2	3.5	1.7	1.9	0.9	1.2
Illnesses of mother	1.7	2.1	7.1	0.9	0.6	0.5	2.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.7	1.3	-0.5	-0.2	0.9
Pulse wave Arterial Stiffness index	0.4	0.5	1.0	-1.0	-0.7	-0.1	-0.6
Impedance of arm (left)	0.3	1.5	2.6	1.2	1.5	-1.6	-0.0
Arm fat mass (right)	0.6	2.4	4.8	-1.9	-0.0	2.2	-1.0
Trunk predicted mass	0.1	0.6	2.1	0.3	0.1	0.3	1.5
Standing height	0.4	4.4	5.9	2.4	0.7	-2.4	2.4
Length of working week for main job	0.9	1.0	1.5	1.2	1.1	0.9	0.7
Exposure to tobacco smoke at home	0.3	0.3	0.3	0.6	-0.6	0.5	-0.5
Breastfed as a baby	0.2	0.2	0.4	0.4	0.6	0.3	0.4
Tense / ‘highly strung’	1.3	2.2	4.0	-2.0	-0.1	1.7	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.5	3.8	7.1	-1.9	-2.2	0.1	-2.7
Hair/balding pattern: Pattern 4	0.3	0.6	1.6	-1.3	-0.7	-0.3	-0.5
Birth weight of first child	1.4	2.6	7.5	1.2	1.2	-0.4	2.7
Peak expiratory flow (PEF)	0.4	0.9	2.3	0.6	1.5	0.9	-0.4
Pulse wave reflection index	0.2	0.2	0.3	0.3	-0.5	0.1	0.6
Ever highly irritable/argumentative for 2 days	0.0	0.1	0.1	-0.2	-0.3	0.2	-0.2
Loud music exposure frequency	0.7	0.7	1.2	-0.7	0.3	1.0	1.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.4	-1.2	0.8	-0.0	-2.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.6	-1.1	-0.4	1.3	-0.7
Blood clot in the leg (DVT)	0.4	0.6	1.8	-0.6	0.2	1.4	0.1
Medication: Paracetamol	0.4	0.7	1.9	-1.4	-0.9	-0.2	-0.2
Headache pain in last month	0.1	0.1	0.2	-0.4	0.2	0.4	0.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.4	0.6	0.6	-0.2	1.5
Glaucoma (self-reported)	0.2	0.3	0.5	-0.7	0.2	-0.6	0.4
Gout (self-reported)	0.9	1.2	2.7	-0.9	-1.6	0.2	-1.1
Hypothyroidism/myxoedema (self-reported)	1.8	3.6	7.3	-1.3	2.1	2.7	-0.8
Medication: Amlodipine	0.5	0.7	1.9	-0.7	0.2	-1.4	-0.7
Medication: Ventolin 100micrograms inhaler	1.7	2.2	4.5	-1.9	0.4	2.1	-0.7
Birth weight	3.7	8.0	17.6	4.2	2.1	-1.3	2.9
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.3	-0.9	-0.0	1.8	-0.8
High blood pressure (siblings)	0.6	0.9	1.7	0.1	-0.9	-1.3	1.0
Forced vital capacity (FVC), Best measure	0.3	1.0	2.3	1.5	-0.9	-0.4	1.0
Body fat percentage	0.9	3.7	6.2	-2.5	-0.2	2.2	-1.9
Leg fat percentage (right)	1.3	4.6	7.5	-2.7	-0.6	2.5	-2.1
Arm fat-free mass (right)	0.1	0.4	1.4	0.1	-0.3	0.3	1.2
Exposure to tobacco smoke outside home	1.1	1.5	4.9	-2.2	-0.7	0.3	-0.8
Comparative body size at age 10	0.5	1.3	3.2	-1.1	-0.6	0.8	-1.8
Number of full brothers	0.6	0.7	1.1	-0.4	-1.1	-1.0	0.8
Worry too long after embarrassment	0.7	1.2	2.6	-0.5	1.6	1.3	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.7	-1.3	0.1	0.5	-0.5
Wheeze or whistling in the chest in last year	1.3	2.4	6.1	-0.0	1.8	2.5	-0.5
Number of children fathered	3.9	4.4	9.3	2.3	3.0	0.0	1.8
Reason for reducing amount of alcohol drunk: Health precaution	3.3	3.8	8.6	-2.0	-1.5	0.3	-2.9
Age at first live birth	0.8	1.4	3.6	1.9	0.6	-0.5	1.1
Pulse wave peak to peak time	0.7	0.8	1.9	1.4	0.7	-0.1	1.0
Health satisfaction	0.6	0.8	2.1	-0.8	-1.5	0.3	-0.7
Shortness of breath walking on level ground	0.3	0.4	0.9	-0.3	0.9	0.8	-0.3
Qualifications: College or University degree	1.3	4.1	7.6	-2.3	1.0	1.7	-2.8
Eye problems/disorders: None of the above	3.7	4.3	6.8	2.6	-2.2	-0.9	2.2
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.8	-1.4	-1.2	0.1	-0.8
Emphysema/chronic bronchitis	0.7	0.7	1.0	-0.8	-0.8	0.9	-1.0
Medication for pain relief, constipation, heartburn	1.1	1.9	3.7	1.9	0.6	-1.4	1.3
Neck or shoulder pain in last month	1.0	1.5	2.5	-1.2	-0.6	1.3	-1.6
Medication: Blood pressure	0.6	1.1	3.5	-0.4	-0.6	0.5	-1.9
Angina (self-reported)	1.3	1.7	4.8	-1.1	-1.0	0.3	-2.2
Migraine (self-reported)	0.3	0.4	0.6	-0.8	0.7	0.7	-0.2
Medication: Ibuprofen	0.3	0.4	0.6	-0.5	0.7	0.8	-0.4
Medication: Allopurinol	3.0	4.0	7.7	-1.4	-2.8	0.7	-2.4
Medication: Omeprazole	0.9	1.1	2.9	-0.8	1.7	0.5	0.7
Medication: Seretide 50 evohaler	1.4	1.6	3.0	-0.9	-1.5	0.7	-1.7
Mean time to correctly identify matches	0.7	1.3	3.1	0.1	-1.4	-1.8	-0.1
Heart disease (mother)	2.7	3.3	7.9	-2.8	-0.8	0.8	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	0.1	0.5	0.5	-0.6
Whole body fat mass	0.6	2.4	4.5	-1.9	-0.3	2.1	-1.1
Leg fat mass (right)	0.7	2.9	5.7	-2.0	-0.2	2.4	-1.3
Arm predicted mass (right)	0.1	0.6	1.9	0.2	0.1	0.7	1.4
Pulse rate, automated reading	0.8	2.6	4.1	-2.0	1.4	0.4	-2.0
Alcohol intake frequency.	0.8	1.8	4.9	-0.4	1.2	2.2	-0.7
Comparative height size at age 10	0.1	0.4	1.1	1.1	0.7	-0.3	0.2
Number of full sisters	1.7	2.1	7.4	-0.4	-0.6	2.7	0.6
Suffer from ‘nerves’	0.9	1.4	3.8	-1.9	1.0	0.5	-0.8
Overall health rating	0.8	1.7	3.0	-1.2	-1.7	1.2	-0.9
Chest pain or discomfort	0.2	0.2	0.4	-0.2	0.5	0.4	-0.6
Had major operations	3.8	4.4	10.5	-1.1	1.9	3.2	-1.6
Age at last live birth	1.2	1.7	4.4	2.1	-0.4	-1.4	0.4
Family relationship satisfaction	0.3	0.3	1.3	-0.3	0.2	-0.0	-1.1
Leg pain on walking	1.1	1.4	4.6	-0.6	-0.8	-0.1	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.7	1.1	-0.7	-0.3	1.3
Commuting to job workplace: Car/motor vehicle	1.6	1.8	3.1	1.6	-0.2	-1.3	1.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.1	0.5	1.5	0.4	0.5
Medication: Aspirin	3.1	4.1	6.5	-2.5	-1.0	2.3	-1.9
Supplements: Vitamin C	1.1	1.3	2.9	0.9	1.0	-1.7	0.6
Knee pain experienced in last month	2.4	3.8	7.8	-2.8	-0.9	1.1	-2.3
Hypertension (Self-reported)	1.1	2.9	8.4	-1.5	-1.1	-0.2	-2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.1	-1.8	1.2	0.6	0.3
Illnesses of father: Heart disease	1.2	1.7	3.7	-1.9	-0.3	0.4	-1.7
Illnesses of siblings: Diabetes	1.4	1.8	4.9	-2.2	-0.3	0.3	-1.4
Smoking status: Previous	0.3	0.4	0.8	-0.4	-0.2	0.9	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.7	0.8	-0.1	0.1	1.9
Whole body fat-free mass	0.1	0.6	2.0	0.2	0.3	0.6	1.4
Leg fat-free mass (right)	0.2	0.9	1.7	0.2	0.7	1.2	1.3
Arm fat percentage (left)	0.8	3.3	6.5	-2.1	0.6	2.5	-1.4
Average weekly red wine intake	0.3	0.4	1.3	-0.3	0.1	-1.1	-0.6
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.0	0.3	-0.1	1.4	1.2
Mood swings	0.5	0.8	1.7	-0.2	-1.3	-1.0	0.8
Loneliness, isolation	0.9	1.3	3.1	-1.7	-1.1	0.4	-0.9
Long-standing illness, disability or infirmity	2.5	3.8	6.4	-2.1	-1.0	1.9	-2.5
Ever had bowel cancer screening	1.2	1.5	4.7	-0.9	-0.1	0.6	-2.2
Diabetes diagnosed by doctor	0.9	1.5	3.5	-1.1	-0.4	1.1	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.3	0.6	-0.7	-1.1	-0.4
Friendships satisfaction	0.4	0.5	1.2	1.1	-0.1	0.1	1.0
Qualifications: nursing, teaching	1.3	2.0	3.3	-1.0	1.8	1.1	-1.6
Commuting to job workplace: Walk	0.6	0.6	1.6	-1.3	0.6	0.0	-0.8
Eye problems/disorders: Cataract	0.1	0.1	0.1	-0.2	0.4	-0.2	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.8	-0.4	-0.9	-0.7	-0.7
Medication for cholesterol	0.6	0.8	2.1	1.5	0.3	0.0	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.8	0.7	0.3	-0.8	0.9
Back pain experienced in last month	0.4	0.6	2.0	-1.4	0.2	0.0	-0.6
Mineral and other dietary supplements	0.6	0.8	2.3	-0.4	-0.5	0.8	1.5
Breast cancer (self-reported)	0.9	1.1	2.0	1.1	0.3	-1.0	1.4
Asthma (self-reported)	0.4	0.8	2.3	-0.7	0.7	1.5	0.4
Osteoporosis (self-reported)	0.4	0.5	1.3	0.5	-0.7	-0.3	-1.1
Osteoarthritis (self-reported)	2.4	3.2	4.3	-2.1	-1.4	1.4	-2.0
Medication: Aspirin	3.0	3.9	6.5	-2.5	-0.7	2.2	-1.9
Medication: Gliclazide	0.2	0.2	0.4	0.5	-0.5	0.7	-0.2
Illnesses of father: None of the above (group 1)	0.7	0.9	1.2	0.9	0.8	0.9	1.1
Smoking status: Current	0.2	0.3	0.6	0.7	-0.7	-0.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.3	1.1	-1.8	-0.0	-0.4
Whole body water mass	0.1	0.6	1.8	0.2	0.3	0.6	1.4
Leg predicted mass (right)	0.2	0.9	1.8	0.1	0.6	1.1	1.4
Arm fat mass (left)	0.5	2.1	4.8	-1.7	-0.0	2.2	-0.8
Number of self-reported non-cancer illnesses	4.3	7.5	10.8	-3.3	-0.0	3.2	-3.0
Average weekly champagne plus white wine intake	0.5	0.7	1.7	-0.8	0.4	1.3	-0.6
Miserableness	2.1	3.6	10.6	-3.3	-0.5	0.6	-1.8
Guilty feelings	0.9	1.4	3.6	-1.9	0.2	0.5	-1.3
Wears glasses or contact lenses	1.2	1.4	4.9	-0.5	2.2	0.5	0.3
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.2	0.0	0.5	-0.2
Hearing aid user	0.6	0.6	1.3	0.0	1.1	0.1	-1.1
Mother’s age at death	0.3	0.4	1.0	1.0	-0.6	-0.2	-0.1
Financial situation satisfaction	0.0	0.0	0.1	-0.3	-0.1	0.1	0.2
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	-0.8	-0.1	0.5	-0.4
Commuting to job workplace: Public transport	1.4	1.7	3.4	-1.8	0.5	1.5	-0.9
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	-0.7	0.3	-0.7	-0.1
Medication: Blood pressure	0.9	1.8	4.2	-2.1	-0.2	-1.2	-1.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	-0.4	-0.7	-0.5	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.2	0.5	-0.2	-0.5
High cholesterol (Self-reported)	0.5	0.8	2.4	-0.4	0.3	0.8	-1.6
Medication: Bendroflumethiazide	0.3	0.5	0.9	-0.9	0.9	-0.0	-0.6
Medication: Paracetamol	0.8	1.2	2.1	-1.4	-1.5	-0.9	-0.0
Medication: Lisinopril	0.3	0.3	0.4	0.6	-0.7	-0.5	-0.6
Medication: Atorvastatin	4.1	5.1	12.2	-3.5	0.7	2.5	-1.1
Illnesses of father: High blood pressure	0.3	0.3	0.8	-0.6	-0.1	0.9	-0.3
Alcohol drinker status: Never	0.4	0.4	1.0	-0.4	-0.7	-0.2	1.0
Ever smoked	0.1	0.2	0.4	0.1	-0.1	0.6	-0.7
Basal metabolic rate	0.1	0.6	1.3	-0.1	0.3	1.0	1.1
Leg fat percentage (left)	1.2	4.4	6.8	-2.6	-1.1	2.5	-1.8
Arm fat-free mass (left)	0.1	0.5	0.8	-0.4	-0.7	0.6	0.9
Number of operations (self-reported)	1.0	1.4	4.6	-2.1	0.5	1.0	-0.0
Average weekly beer plus cider intake	2.1	3.0	3.5	1.9	-1.7	-1.4	1.9
Irritability	0.2	0.4	1.4	0.1	-1.2	-0.2	0.0
Risk taking	2.8	4.1	8.5	-2.2	-1.7	-0.5	-2.9
Ever had prostate specific antigen (PSA) test	1.9	2.1	4.7	-1.3	0.6	1.4	-2.2
Fractured/broken bones in last 5 years	0.9	1.2	2.8	-1.2	-0.2	0.7	-1.7
Age started oral contraceptive pill	1.0	1.3	2.8	-1.0	1.7	0.3	-1.1
Diastolic blood pressure, automated reading	0.5	1.7	3.6	-1.0	-1.2	-1.9	-0.8
Ever depressed for a whole week	3.0	3.7	7.5	-2.7	0.3	0.3	-2.7
Unable to work because of sickness or disability	0.7	0.9	1.3	-0.9	-0.7	1.1	-1.1
Commuting to job workplace: Cycle	2.0	2.4	7.5	0.9	2.7	1.1	-0.4
Myopia	0.3	0.4	0.9	1.0	-0.7	0.2	0.4
Vascular/heart problems diagnosed by doctor	1.3	3.7	8.2	1.8	1.6	0.9	2.9
Cholesterol lowering medication	0.1	0.2	0.6	0.0	0.1	0.2	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.4	-1.2	1.2	0.7	0.1
Pain experienced in last month	2.3	3.9	7.2	2.7	1.2	-0.2	2.6
Supplements: Calcium	1.0	1.1	2.0	-0.7	0.3	-1.4	-1.4
Basal cell carcinoma (self-reported)	1.5	1.8	4.0	-1.1	-1.1	-0.8	-2.0
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.8	-0.2	-0.9	-0.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.1	-0.4	-0.1	1.1	-0.0
Heart disease (siblings)	2.1	2.6	4.7	0.3	1.0	2.2	-2.1
Alcohol drinker status: Previous	1.9	2.2	3.8	-1.9	-0.5	1.0	-1.9
Pack years of smoking	0.7	1.0	3.2	-1.8	-0.7	-0.2	-0.5
Impedance of whole body	0.3	1.4	4.9	0.9	-0.1	-2.2	-0.2
Leg fat mass (left)	0.7	2.7	5.7	-1.9	-0.5	2.4	-1.1
Arm predicted mass (left)	0.1	0.5	1.1	-0.3	-0.5	0.6	1.0