[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr1:77,464,831-79,300,939

Best TWAS P=8.49e-22 · Best GWAS P=2.32e-15 conditioned to 0.229

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	GIPC2	0.10	0.11	blup	64	0.13	1.1e-13	-7.3	9.6	8.5e-22	-0.74	0.01	0.99	TRUE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	GIPC2	0.04	0.01	blup	65	0.00	2.5e-01	-6.5	8.4	6.5e-17	-0.79	0.02	0.66	FALSE
8	GTEx	Spleen	GIPC2	0.43	0.07	enet	19	0.22	2.9e-06	-6.5	8.1	5.7e-16	-0.89	0.04	0.95	FALSE
4	GTEx	Lung	GIPC2	0.15	0.09	enet	17	0.12	2.5e-09	-7.7	8.1	6.1e-16	-0.85	0.02	0.98	FALSE
9	METSIM	Adipose	DNAJB4	0.04	0.04	lasso	4	0.03	2.1e-05	-7.3	-8.0	9.0e-16	0.71	0.06	0.92	FALSE
24	The Cancer Genome Atlas	Testicular Germ Cell Tumors	NEXN	0.09	0.04	blup	43	0.05	9.3e-03	5.6	-8.0	1.1e-15	0.28	0.02	0.06	FALSE
5	GTEx	Nerve Tibial	DNAJB4	0.08	0.07	lasso	3	0.07	1.3e-05	-7.9	-7.9	2.3e-15	0.97	0.01	0.99	FALSE
7	GTEx	Skin Sun Exposed Lower leg	DNAJB4	0.07	0.05	lasso	5	0.05	6.5e-05	-7.9	-7.9	2.5e-15	0.96	0.01	0.99	FALSE
14	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DNAJB4	0.05	0.03	lasso	3	0.02	3.3e-03	-7.6	-7.9	2.6e-15	0.93	0.00	0.98	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	DNAJB4	0.08	0.09	lasso	2	0.09	1.3e-11	-7.9	-7.9	2.9e-15	1.00	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	DNAJB4	0.08	0.07	lasso	1	0.06	9.3e-08	-7.6	-7.6	2.3e-14	0.98	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DNAJB4	0.24	0.14	lasso	1	0.11	1.1e-04	-7.6	-7.6	2.3e-14	0.98	0.00	0.98	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NEXN	0.03	0.01	blup	44	0.01	1.3e-02	6.7	-7.5	4.8e-14	0.15	0.02	0.03	FALSE
2	GTEx	Cells EBV-transformed lymphocytes	NEXN	0.23	0.10	lasso	3	0.08	1.4e-03	-7.6	-7.5	5.8e-14	0.87	0.02	0.90	FALSE
17	The Cancer Genome Atlas	Glioblastoma Multiforme	NEXN	0.16	0.05	blup	44	0.02	9.7e-02	6.1	-7.0	1.9e-12	0.16	0.01	0.06	FALSE
3	GTEx	Cells Transformed fibroblasts	NEXN	0.11	0.06	lasso	5	0.07	9.6e-06	6.1	-6.9	6.2e-12	0.19	0.54	0.37	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	GIPC2	0.02	0.02	lasso	3	0.02	1.0e-03	-6.6	6.8	1.3e-11	-0.78	0.12	0.68	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	FAM73A	0.09	0.04	enet	19	0.06	9.6e-09	6.9	-6.8	1.5e-11	0.07	0.73	0.27	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	NEXN	0.11	0.07	blup	365	0.10	2.2e-13	6.9	-6.7	3.0e-11	0.15	0.73	0.27	FALSE
10	METSIM	Adipose	FAM73A	0.03	0.00	bslmm	444	0.01	4.3e-02	6.9	-6.4	2.1e-10	0.22	0.19	0.05	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	GIPC2	0.02	0.02	lasso	2	0.02	8.3e-05	-5.7	6.0	2.2e-09	-0.58	0.46	0.20	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	GIPC2	0.07	0.05	blup	64	0.06	1.5e-06	-2.4	6.0	2.7e-09	-0.56	0.23	0.66	FALSE
6	GTEx	Pancreas	GIPC2	0.41	0.13	enet	29	0.14	1.1e-06	-7.6	5.8	6.1e-09	-0.69	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	USP33	0.04	0.02	blup	455	0.02	2.0e-03	2.4	5.7	1.4e-08	-0.48	0.59	0.29	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	NEXN	0.03	0.02	blup	44	0.03	6.6e-04	6.9	-5.7	1.5e-08	0.08	0.20	0.18	FALSE