Best TWAS P=8.49e-22 · Best GWAS P=2.32e-15 conditioned to 0.229
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | USP33 | 0.04 | 0.02 | blup | 455 | 0.02 | 2.0e-03 | 2.4 | 5.7 | 1.4e-08 | -0.48 | 0.59 | 0.29 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | NEXN | 0.23 | 0.10 | lasso | 3 | 0.08 | 1.4e-03 | -7.6 | -7.5 | 5.8e-14 | 0.87 | 0.02 | 0.90 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | NEXN | 0.11 | 0.06 | lasso | 5 | 0.07 | 9.6e-06 | 6.1 | -6.9 | 6.2e-12 | 0.19 | 0.54 | 0.37 | FALSE |
| 4 | GTEx | Lung | GIPC2 | 0.15 | 0.09 | enet | 17 | 0.12 | 2.5e-09 | -7.7 | 8.1 | 6.1e-16 | -0.85 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Nerve Tibial | DNAJB4 | 0.08 | 0.07 | lasso | 3 | 0.07 | 1.3e-05 | -7.9 | -7.9 | 2.3e-15 | 0.97 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Pancreas | GIPC2 | 0.41 | 0.13 | enet | 29 | 0.14 | 1.1e-06 | -7.6 | 5.8 | 6.1e-09 | -0.69 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | DNAJB4 | 0.07 | 0.05 | lasso | 5 | 0.05 | 6.5e-05 | -7.9 | -7.9 | 2.5e-15 | 0.96 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Spleen | GIPC2 | 0.43 | 0.07 | enet | 19 | 0.22 | 2.9e-06 | -6.5 | 8.1 | 5.7e-16 | -0.89 | 0.04 | 0.95 | FALSE |
| 9 | METSIM | Adipose | DNAJB4 | 0.04 | 0.04 | lasso | 4 | 0.03 | 2.1e-05 | -7.3 | -8.0 | 9.0e-16 | 0.71 | 0.06 | 0.92 | FALSE |
| 10 | METSIM | Adipose | FAM73A | 0.03 | 0.00 | bslmm | 444 | 0.01 | 4.3e-02 | 6.9 | -6.4 | 2.1e-10 | 0.22 | 0.19 | 0.05 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | NEXN | 0.11 | 0.07 | blup | 365 | 0.10 | 2.2e-13 | 6.9 | -6.7 | 3.0e-11 | 0.15 | 0.73 | 0.27 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | DNAJB4 | 0.08 | 0.09 | lasso | 2 | 0.09 | 1.3e-11 | -7.9 | -7.9 | 2.9e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | FAM73A | 0.09 | 0.04 | enet | 19 | 0.06 | 9.6e-09 | 6.9 | -6.8 | 1.5e-11 | 0.07 | 0.73 | 0.27 | FALSE |
| 14 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | DNAJB4 | 0.05 | 0.03 | lasso | 3 | 0.02 | 3.3e-03 | -7.6 | -7.9 | 2.6e-15 | 0.93 | 0.00 | 0.98 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GIPC2 | 0.02 | 0.02 | lasso | 2 | 0.02 | 8.3e-05 | -5.7 | 6.0 | 2.2e-09 | -0.58 | 0.46 | 0.20 | FALSE |
| 16 | The Cancer Genome Atlas | Colon Adenocarcinoma | GIPC2 | 0.04 | 0.01 | blup | 65 | 0.00 | 2.5e-01 | -6.5 | 8.4 | 6.5e-17 | -0.79 | 0.02 | 0.66 | FALSE |
| 17 | The Cancer Genome Atlas | Glioblastoma Multiforme | NEXN | 0.16 | 0.05 | blup | 44 | 0.02 | 9.7e-02 | 6.1 | -7.0 | 1.9e-12 | 0.16 | 0.01 | 0.06 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NEXN | 0.03 | 0.01 | blup | 44 | 0.01 | 1.3e-02 | 6.7 | -7.5 | 4.8e-14 | 0.15 | 0.02 | 0.03 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DNAJB4 | 0.08 | 0.07 | lasso | 1 | 0.06 | 9.3e-08 | -7.6 | -7.6 | 2.3e-14 | 0.98 | 0.00 | 1.00 | FALSE |
| 20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GIPC2 | 0.02 | 0.02 | lasso | 3 | 0.02 | 1.0e-03 | -6.6 | 6.8 | 1.3e-11 | -0.78 | 0.12 | 0.68 | FALSE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NEXN | 0.03 | 0.02 | blup | 44 | 0.03 | 6.6e-04 | 6.9 | -5.7 | 1.5e-08 | 0.08 | 0.20 | 0.18 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GIPC2 | 0.10 | 0.11 | blup | 64 | 0.13 | 1.1e-13 | -7.3 | 9.6 | 8.5e-22 | -0.74 | 0.01 | 0.99 | TRUE |
| 23 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | DNAJB4 | 0.24 | 0.14 | lasso | 1 | 0.11 | 1.1e-04 | -7.6 | -7.6 | 2.3e-14 | 0.98 | 0.00 | 0.98 | FALSE |
| 24 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | NEXN | 0.09 | 0.04 | blup | 43 | 0.05 | 9.3e-03 | 5.6 | -8.0 | 1.1e-15 | 0.28 | 0.02 | 0.06 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | GIPC2 | 0.07 | 0.05 | blup | 64 | 0.06 | 1.5e-06 | -2.4 | 6.0 | 2.7e-09 | -0.56 | 0.23 | 0.66 | FALSE |