TWAS hub - USP33

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0390	0.0170	5.6e-04	0.022	0.019	0.012	0.016	0.014	9.2e-04	2.0e-03	1.0e-02	0.0045	6.5e-03
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0686	0.0397	8.1e-04	0.021	0.015	0.012	NA	0.008	2.0e-03	7.7e-03	1.6e-02	NA	3.6e-02
3	TCGA	Prostate Adenocarcinoma	0.1506	0.0766	1.4e-08	0.070	0.071	0.084	NA	0.084	8.7e-08	7.1e-08	4.6e-09	NA	3.8e-09
4	TCGA	Thyroid Carcinoma	0.0350	0.0290	1.5e-03	0.005	0.018	0.004	NA	0.002	9.0e-02	7.0e-03	1.2e-01	NA	1.9e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Alcohol intake versus 10 years previously	7.7	11.6	15.1	-2.5	-3.8	-3.9	-3.2
Peak expiratory flow (PEF)	7.6	17.6	27.6	5.1	1.3	3.9	5.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.6	14.0	15.7	3.6	3.7	4.0	3.6
Supplements: Fish oil (including cod liver oil)	6.6	8.6	11.3	2.8	2.6	3.4	2.9
Lung FVC	4.8	24.2	35.9	4.4	3.3	6.0	5.5
Number of incorrect matches in round	4.7	7.9	11.8	1.5	3.4	3.0	2.8
Forced expiratory volume in 1-second (FEV1)	4.7	15.7	23.9	4.9	0.8	3.8	4.9
Guilty feelings	4.7	7.0	10.4	2.6	2.2	2.4	3.2
Commuting to job workplace: Cycle	4.6	5.6	9.4	1.6	3.1	2.0	2.5
Back pain experienced in last month	4.4	6.4	11.4	3.4	0.6	2.3	2.9
Worrier / anxious feelings	4.3	8.2	10.9	2.6	2.5	3.3	3.0
Mineral and other dietary supplements	4.3	5.8	7.6	-1.9	-2.6	-2.8	-2.2
Tinnitus: Yes, now most or all of the time	4.2	4.9	8.4	2.5	1.1	2.0	2.9
Forced expiratory volume in 1-second (FEV1), Best measure	3.9	12.6	22.0	4.7	0.3	3.3	4.2
Lung cancer (father)	3.7	4.3	7.5	-0.4	-2.5	-2.7	-1.8
Financial situation satisfaction	3.4	4.2	6.0	-1.8	-2.5	-2.0	-1.9
Forced vital capacity (FVC)	3.2	12.4	19.5	4.0	0.3	3.7	4.4
Suffer from ‘nerves’	3.2	5.1	8.2	1.4	2.9	2.3	2.1
Family relationship satisfaction	3.1	3.8	9.6	-3.1	-1.3	-0.7	-1.8
Neuroticism score	2.9	6.0	8.2	2.1	2.0	2.9	2.7
Forced vital capacity (FVC), Best measure	2.9	10.4	15.8	3.9	-0.3	3.3	4.0
Pain type(s) experienced in last month: Hip pain	2.9	3.7	7.7	2.8	0.8	1.4	2.1
Time employed in main current job	2.7	3.1	5.3	1.4	2.3	1.9	1.2
Medication: Ventolin 100micrograms inhaler	2.6	3.3	4.8	2.0	0.3	2.2	2.1
Chest pain or discomfort	2.5	3.5	5.9	-1.3	-2.2	-2.4	-1.3
Supplements: Vitamin C	2.5	3.0	4.3	1.6	2.1	2.0	1.1
Alcohol usually taken with meals	2.4	3.9	5.0	1.9	1.6	2.1	2.2
Lung FEV1/FVC ratio	2.3	11.8	32.3	5.7	1.7	1.8	3.0
Birth weight of first child	2.3	4.2	6.3	2.5	0.2	2.1	2.5
Qualifications: None of the above	2.2	4.7	7.7	-1.7	-2.8	-2.1	-1.9
Medication: Seretide 50 evohaler	2.2	2.5	4.4	-1.5	-0.5	-2.1	-1.7
Nervous feelings	2.1	4.0	10.9	0.5	3.3	2.0	0.9
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.3	7.5	2.7	-0.4	2.1	2.3
Heart attack/myocardial infarction (self-reported)	2.1	2.7	6.1	-0.5	-2.5	-1.9	-1.0
Prostate Cancer	2.0	2.8	5.0	2.2	1.2	1.3	1.7
Ever taken oral contraceptive pill	2.0	2.2	3.6	-1.9	-0.6	-1.7	-1.5
Alcohol drinker status: Never	2.0	2.4	3.6	1.9	1.3	1.5	1.5
Vitamin and mineral supplements	1.9	2.6	4.0	-1.3	-1.5	-2.0	-1.6
Fed-up feelings	1.9	3.4	5.4	1.6	-1.0	2.3	2.1
Worry too long after embarrassment	1.9	3.2	6.4	1.4	-0.1	2.2	2.5
Neuroticism (Nagel 2018)	1.8	4.2	6.4	1.5	1.7	2.5	2.3
Bipolar Disorder (2011)	1.8	1.7	4.6	-0.2	2.1	1.3	0.7
BMI	1.8	10.3	26.1	-0.1	-5.1	-3.2	-2.2
Impedance of leg (right)	1.8	8.5	20.9	2.0	4.6	1.9	2.4
Birth weight	1.8	3.9	6.7	2.1	0.8	2.6	1.9
Ulcerative Colitis	1.7	2.5	3.6	1.4	0.8	1.9	1.9
Neuroticism	1.7	4.1	5.7	1.5	1.9	2.4	2.1
Impedance of leg (left)	1.7	8.1	17.6	2.1	4.2	1.8	2.7
Leg predicted mass (left)	1.7	8.8	31.8	0.2	-5.6	-1.4	-1.1
Had menopause	1.7	2.1	3.4	-1.0	-1.5	-1.9	-1.4
Arm fat mass (right)	1.7	6.9	19.6	-0.0	-4.4	-2.4	-1.6
Leg fat-free mass (right)	1.7	9.3	34.0	0.1	-5.8	-1.4	-1.0
Leg predicted mass (right)	1.7	9.3	33.9	0.1	-5.8	-1.5	-1.1
Bipolar Disorder or Schizophrenia	1.6	3.9	8.9	1.4	3.0	1.8	1.1
Crohns Disease (2012)	1.6	2.5	4.2	1.3	2.1	1.6	1.2
Leg fat-free mass (left)	1.6	8.7	31.6	0.3	-5.6	-1.4	-1.1
Exposure to tobacco smoke at home	1.6	1.8	2.7	-1.1	-1.2	-1.3	-1.6
Qualifications: nursing, teaching	1.6	2.6	6.7	0.4	1.5	2.6	1.1
Miserableness	1.6	2.8	6.5	0.9	0.3	2.5	1.9
Arm predicted mass (left)	1.6	8.0	28.6	1.8	-5.3	-0.5	0.3
Age at First Birth	1.5	2.1	6.0	1.2	2.4	0.9	0.6
Number of live births	1.5	2.1	3.5	1.4	0.3	1.9	1.7
Pulse wave reflection index	1.5	1.8	2.8	-1.5	-0.6	-1.3	-1.7
Headache pain in last month	1.5	2.5	7.3	-1.4	-2.7	-0.3	-0.8
Age at first live birth	1.5	2.6	7.3	-0.2	2.7	1.7	0.6
Age at last live birth	1.5	2.2	6.6	-0.7	2.6	1.4	0.4
Arm fat mass (left)	1.5	6.4	19.5	0.2	-4.4	-2.1	-1.3
Basal metabolic rate	1.5	8.3	30.6	1.3	-5.5	-0.9	-0.4
Arm fat-free mass (left)	1.5	7.6	27.1	1.8	-5.2	-0.5	0.1
Primary Biliary Cirrhosis	1.4	2.0	2.7	-1.6	-1.6	-1.0	-1.4
Average weekly spirits intake	1.4	1.7	3.0	-1.2	-1.0	-1.1	-1.7
Multivitamins +/- minerals	1.4	1.8	2.7	1.0	1.6	1.6	1.0
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	2.7	-1.6	-0.2	-1.4	-1.5
Heart attack	1.4	1.8	4.6	-0.2	-2.1	-1.5	-0.7
Weight	1.4	6.9	23.9	1.3	-4.9	-1.3	-0.5
Arm fat percentage (right)	1.4	5.5	10.7	-0.7	-3.3	-2.7	-1.8
Medication: Paracetamol	1.4	2.2	4.2	1.1	2.0	1.4	1.2
Chronic bronchitis/emphysema (mother)	1.4	1.6	4.2	-0.5	-0.3	-2.0	-1.4
Arm fat-free mass (right)	1.4	7.1	20.9	2.6	-4.6	0.4	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	2.9	-1.5	-0.6	-0.8	-1.7
Arm predicted mass (right)	1.4	7.0	18.5	2.7	-4.3	0.7	1.2
Had major operations	1.4	1.6	4.2	-0.7	-0.3	-2.1	-1.3
Whole body fat-free mass	1.4	8.1	30.2	1.3	-5.5	-0.6	-0.2
Whole body water mass	1.4	8.1	30.0	1.4	-5.5	-0.5	-0.2
Ever had prostate specific antigen (PSA) test	1.4	1.7	2.4	1.1	1.5	1.3	1.2
Bipolar Disorder (2018)	1.3	2.1	5.0	0.4	2.2	1.6	0.9
Chronotype (morning person)	1.3	2.9	4.9	-1.6	-1.1	-2.2	-1.7
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.0	-1.2	-1.4	-1.1	-1.1
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.3	1.5	1.1	1.2	1.1
Trunk predicted mass	1.3	7.3	25.9	1.8	-5.1	-0.2	0.1
Ever had bowel cancer screening	1.3	1.5	2.0	1.4	0.8	1.2	1.4
Wears glasses or contact lenses	1.3	1.5	2.1	0.9	1.4	1.4	1.1
Body Mass Index (BMI) (2010)	1.2	1.6	5.2	0.5	-2.3	-0.9	-0.6
Blood White Count	1.2	8.8	11.3	-3.0	-3.4	-2.2	-3.2
Sensitivity / hurt feelings	1.2	2.0	3.6	0.6	1.5	1.9	1.3
Relative age of first facial hair	1.2	2.5	4.7	-1.2	-1.4	-2.2	-1.3
Hand grip strength (right)	1.2	3.3	5.7	2.4	-0.6	1.8	1.9
Body mass index (BMI)	1.2	5.3	15.4	0.2	-3.9	-2.0	-1.2
Trunk fat-free mass	1.2	7.1	25.1	1.8	-5.0	-0.1	0.2
Happiness	1.2	1.5	3.4	-1.9	0.7	-0.2	-1.4
Illnesses of mother	1.2	1.5	2.2	1.5	-0.1	1.5	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	4.0	0.3	2.0	1.1	0.9
Mean time to correctly identify matches	1.2	2.2	4.0	-1.2	2.0	1.8	0.2
Worry (Nagel 2018)	1.1	2.3	5.5	0.6	2.4	1.4	1.2
Allergy or Eczema	1.1	2.8	4.0	-2.0	-1.8	-1.6	-1.2
Hand grip strength (left)	1.1	2.8	4.7	2.2	-0.4	1.7	1.9
Hayfever, allergic rhinitis or eczema	1.1	2.5	3.0	-1.7	-1.6	-1.6	-1.4
Trunk fat mass	1.1	4.6	14.8	0.8	-3.8	-1.6	-0.6
Medication: Blood pressure	1.1	1.9	3.7	-0.9	-1.3	-1.9	-1.2
Medication: Allopurinol	1.1	1.4	2.2	-0.9	-1.4	-1.5	-0.7
Whole body fat mass	1.1	4.5	14.2	0.9	-3.8	-1.7	-0.7
Alcohol intake frequency.	1.1	2.6	4.5	-1.6	-0.4	-1.9	-2.1
Commuting to job workplace: Walk	1.1	1.1	2.2	-1.0	-0.8	-1.5	-0.8
Leg fat mass (left)	1.1	4.5	13.5	1.4	-3.7	-1.5	-0.3
Schizophrenia (2018)	1.0	2.0	4.1	1.5	2.0	1.1	0.8
Reaction Time	1.0	1.9	4.0	-1.2	2.0	1.4	0.1
Lupus	1.0	1.5	2.5	-1.6	-1.4	-0.4	-1.1
Blood Platelet Count	1.0	11.1	20.9	4.6	1.3	3.0	3.6
Sitting height	1.0	7.3	9.4	2.7	-2.2	3.1	2.8
Past tobacco smoking	1.0	1.8	4.1	-0.8	2.0	1.6	0.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.6	0.8	1.9	0.7	1.1
Noisy workplace	1.0	1.2	2.0	-0.8	-0.9	-1.4	-1.2
Leg fat mass (right)	1.0	3.8	11.4	1.4	-3.4	-1.4	-0.4
Illnesses of father: Heart disease	1.0	1.4	1.9	-1.2	-0.7	-1.4	-1.2
Arm fat percentage (left)	1.0	3.9	8.4	-0.3	-2.9	-2.2	-1.5
Medication: Aspirin	1.0	1.3	2.4	-0.9	-1.5	-1.0	-1.0
Commuting to job workplace: Public transport	1.0	1.2	1.9	-1.4	-0.7	-1.3	-1.0
Ever depressed for a whole week	1.0	1.2	1.8	-1.3	0.1	-1.3	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.0	1.4	-0.5	0.7	1.4
HbA1C	0.9	1.1	2.8	1.7	-0.4	0.6	0.9
Townsend deprivation index at recruitment	0.9	1.2	1.5	-1.2	-0.8	-1.1	-1.2
Waist circumference	0.9	3.5	11.4	0.9	-3.4	-1.2	-0.3
Hip circumference	0.9	3.9	12.2	1.6	-3.5	-1.0	-0.1
Comparative height size at age 10	0.9	5.1	11.7	1.6	-3.4	1.5	2.0
Ever smoked	0.9	1.5	3.1	0.1	-1.3	-1.8	-1.1
Supplements: Calcium	0.9	1.0	1.6	1.1	0.2	1.3	1.1
Neuroticism (2016)	0.8	1.2	1.6	0.5	1.3	1.2	1.3
Rheumatoid Arthritis	0.8	1.2	3.8	0.3	-1.9	-0.8	-0.3
Schizophrenia (2014)	0.8	1.8	4.1	1.3	2.0	1.2	0.4
Financial difficulties in last 2 years	0.8	1.0	2.6	-0.6	-1.6	-1.0	-0.4
Hair/balding pattern: Pattern 3	0.8	1.1	1.5	-0.7	-1.2	-1.2	-1.1
Prospective memory result	0.8	1.0	1.2	1.0	0.9	1.1	1.1
Pulse wave Arterial Stiffness index	0.8	0.9	1.6	0.1	-1.1	-1.3	-0.8
Breastfed as a baby	0.8	1.0	3.3	-0.4	1.8	0.8	0.1
Exposure to tobacco smoke outside home	0.8	1.1	2.4	1.6	-0.0	0.5	1.3
Qualifications: College or University degree	0.8	2.6	6.7	0.2	1.6	2.6	1.0
Knee pain experienced in last month	0.8	1.2	3.3	0.7	-1.8	-0.9	0.4
Smoking status: Previous	0.8	1.2	2.3	1.5	-1.4	-0.4	0.7
Long-standing illness, disability or infirmity	0.8	1.3	2.6	-0.5	-1.6	-1.3	-0.8
Illnesses of father: None of the above (group 1)	0.8	0.9	2.1	1.4	0.4	0.4	1.2
Unable to work because of sickness or disability	0.8	1.1	1.7	-1.3	-1.3	-0.9	-0.4
Basal cell carcinoma (self-reported)	0.8	1.0	2.1	-0.9	0.0	-1.0	-1.4
Depressed Affect (Nagel 2018)	0.7	1.4	3.0	0.7	-0.3	1.7	1.4
Schizophrenia vs Biploar Disorder	0.7	1.0	2.5	-0.1	-1.6	-1.1	-0.3
Crohns Disease (2017)	0.7	1.6	2.2	1.5	1.3	1.2	1.1
Breast Cancer	0.7	1.6	2.5	-1.5	-0.2	-1.3	-1.6
Blood Eosinophil Count	0.7	5.6	9.1	-3.0	-1.9	-1.9	-2.4
Trunk fat percentage	0.7	2.9	7.3	0.3	-2.7	-1.9	-0.8
Current tobacco smoking	0.7	1.1	1.7	-0.3	-1.2	-1.1	-1.3
Relative age voice broke	0.7	1.0	2.2	-1.1	0.0	-0.8	-1.5
Chronic bronchitis/emphysema (father)	0.7	0.8	1.6	1.0	-0.8	0.5	1.2
High blood pressure (mother)	0.7	0.9	3.6	0.1	1.9	0.2	0.2
Mouth/teeth dental problems: Dentures	0.7	1.2	2.4	-0.1	-0.2	-1.5	-1.6
Loud music exposure frequency	0.7	0.7	1.3	-1.1	-0.5	-1.0	-0.7
Wheeze or whistling in the chest in last year	0.7	1.3	4.2	0.5	-2.1	-0.1	0.8
Pulse wave peak to peak time	0.7	0.8	1.7	0.1	0.8	1.3	0.9
Neck or shoulder pain in last month	0.7	0.9	1.5	1.2	-0.7	0.6	1.1
Angina (self-reported)	0.7	0.9	1.8	0.6	-1.4	-1.1	0.1
Friendships satisfaction	0.7	0.9	2.8	-0.2	0.5	1.7	0.6
Osteoarthritis (self-reported)	0.7	0.9	2.3	1.5	0.4	0.2	1.0
Smoking status: Current	0.7	1.2	2.0	-0.4	-0.9	-1.3	-1.4
Impedance of whole body	0.7	3.7	13.7	0.1	3.7	0.5	0.9
HDL Cholesterol	0.6	0.9	2.8	-0.2	1.7	1.0	0.2
Height	0.6	11.5	16.2	4.0	-2.5	3.3	3.6
Systolic Blood Pressure	0.6	2.9	4.4	-2.1	2.0	-0.9	-1.6
Systolic blood pressure, automated reading	0.6	1.8	3.1	-1.5	0.2	-1.3	-1.8
Angina	0.6	0.9	1.7	0.7	-1.3	-1.1	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.5	0.3	1.9	1.0	0.8
Supplements: Glucosamine	0.6	0.7	1.9	0.0	1.0	1.4	0.1
Pain all over the body in last month	0.6	0.7	2.2	-0.1	0.1	-1.5	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.1	-0.5	-1.8	-0.5	-0.2
Tense / ‘highly strung’	0.6	1.1	3.5	-0.8	1.9	-0.3	-0.3
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.3	0.8	1.0	1.1	0.9
Body fat percentage	0.6	2.2	5.5	0.7	-2.3	-1.6	-0.5
Comparative body size at age 10	0.6	1.6	2.2	0.9	-1.2	1.5	1.5
Number of children fathered	0.6	0.7	1.2	0.9	-0.4	0.8	1.1
Shortness of breath walking on level ground	0.6	0.7	2.1	1.5	-0.0	0.3	0.7
Mood swings	0.6	1.2	2.5	0.7	-0.4	1.2	1.6
Hearing aid user	0.6	0.7	1.3	0.9	0.3	0.8	1.1
Leg fat percentage (left)	0.6	2.3	4.5	1.8	-2.1	-1.3	0.2
Fractured/broken bones in last 5 years	0.6	0.7	1.8	-0.3	-1.3	-0.7	-0.7
Age started oral contraceptive pill	0.6	0.8	2.6	0.0	1.6	0.6	0.3
Alzheimer’s Disease (in mother)	0.5	0.6	1.4	-1.2	0.5	-0.5	-0.6
Coronary Artery Disease (CAD)	0.5	0.5	1.1	0.5	-1.1	-0.9	-0.1
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.6	1.2	0.1	0.6	1.3
Ever had hysterectomy (womb removed)	0.5	0.6	1.1	1.1	-1.0	0.2	0.5
Diabetes (father)	0.5	0.6	1.2	1.1	-0.0	0.2	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.7	0.1	-1.3	-0.8	-0.0
Stomach or abdominal pain in last month	0.5	0.7	1.2	-1.1	0.0	-0.9	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.1	-0.1	1.8	0.9	0.5
Fluid intelligence score	0.5	1.0	3.7	0.2	-1.9	-0.6	0.3
Impedance of arm (right)	0.5	2.5	5.3	-2.0	2.3	-0.7	-0.6
Impedance of arm (left)	0.5	2.5	7.7	-1.5	2.8	-0.2	-0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.1	-0.7	-0.1	-1.0	-0.8
Glaucoma (self-reported)	0.5	0.6	1.9	-0.6	1.4	-0.2	-0.1
Leg fat percentage (right)	0.5	1.8	2.9	1.7	-1.7	-1.2	0.1
Health satisfaction	0.5	0.6	1.2	-1.1	0.7	-0.4	-0.7
Emphysema/chronic bronchitis	0.5	0.5	1.0	0.8	1.0	0.4	0.6
Medication: Omeprazole	0.5	0.6	1.1	1.0	-0.1	0.6	1.1
Heart disease (mother)	0.5	0.6	1.8	1.4	-0.3	0.3	0.6
Number of full sisters	0.5	0.6	1.7	0.3	1.3	-0.7	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.3	0.6	-0.9	-1.2	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.2	-1.0	-1.1	0.1	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.1	1.4	0.2	0.3	1.0
Medication: Paracetamol	0.5	0.8	2.1	-0.3	1.5	0.9	-0.2
Illnesses of father: High blood pressure	0.5	0.7	2.5	-0.4	1.6	0.3	-0.0
Respiratory disease	0.4	0.9	1.5	-1.2	-1.1	-0.7	-0.7
Number of treatments/medications taken	0.4	0.8	1.7	-1.3	-0.8	-0.2	-0.8
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.0	0.7	-0.2	1.0	0.9
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.9	-0.5	-0.8	-1.0	-0.3
Medication: Co-codamol	0.4	0.5	1.3	0.0	-1.1	-0.9	-0.0
Maternal smoking around birth	0.4	0.6	0.9	1.0	-0.9	-0.5	0.5
Serious illness, injury or assault to yourself	0.4	0.4	1.1	0.2	-1.1	-0.8	0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	0.1	0.7	1.0	0.8
Hearing difficulty/problems with background noise	0.4	0.7	1.3	1.1	-0.9	0.1	0.8
Illnesses of siblings	0.4	0.6	1.0	1.0	-0.0	1.0	0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.8	0.2	-0.8	1.4	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.2	-1.1	-0.1	-0.6	-0.4
Depression (self-reported)	0.4	0.5	0.8	-0.0	0.8	0.9	0.7
Standing height	0.4	4.5	8.2	2.3	-2.9	1.4	1.5
Length of working week for main job	0.4	0.5	0.9	-0.0	-0.2	1.0	1.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	-0.3	-0.9	0.6	0.9
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.5	0.3	-0.1	-1.1	-1.2
Migraine (self-reported)	0.4	0.4	1.4	-0.5	-0.4	1.2	0.3
Overall health rating	0.4	0.8	1.6	-0.7	-1.3	-0.7	-0.8
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.0	1.0	-0.3	0.9	0.5
Medication: Aspirin	0.4	0.5	1.4	-0.2	-1.2	-0.6	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.9	0.1	0.9	1.0	0.2
Mother’s age at death	0.4	0.5	1.1	0.1	0.9	1.0	0.5
Average weekly beer plus cider intake	0.4	0.6	1.1	-0.2	-1.1	-1.1	-0.2
Risk taking	0.4	0.6	1.1	1.1	-0.8	-0.4	0.8
Myopia	0.4	0.6	1.3	1.1	0.7	0.3	0.7
Alzheimer’s Disease (including proxy)	0.3	0.4	0.6	-0.7	0.2	-0.7	-0.8
Irritable Bowel Disease (IBD)	0.3	0.7	1.1	1.0	0.5	0.9	0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.2	0.5	-1.5	0.3	0.5
Ovarian Cancer	0.3	0.4	0.6	-0.5	-0.1	-0.7	-0.8
Fasting Glucose	0.3	0.4	1.2	-0.1	-1.1	-0.6	-0.4
Hypothyroidism (self reported)	0.3	0.7	1.6	-0.0	0.3	-1.0	-1.2
Diabetes (mother)	0.3	0.4	0.9	0.6	0.4	0.5	0.9
Pack years adult smoking proportion	0.3	0.4	1.0	0.6	-1.0	-0.2	0.4
Average weekly fortified wine intake	0.3	0.3	0.6	0.7	0.2	0.3	0.8
Age when periods started (menarche)	0.3	0.7	2.1	-0.4	1.5	0.6	-0.3
Medication: Ramipril	0.3	0.4	0.6	-0.8	0.2	-0.7	-0.5
Medication: Simvastatin	0.3	0.4	0.9	0.3	0.3	0.8	0.9
Medication: Ibuprofen	0.3	0.3	0.7	-0.8	-0.3	-0.2	-0.8
Leg pain on walking	0.3	0.4	1.4	1.2	-0.3	-0.1	-0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.7	0.3	0.8	0.8	0.1
Illnesses of siblings: Diabetes	0.3	0.4	1.0	-1.0	-0.4	-0.5	-0.3
Number of self-reported non-cancer illnesses	0.3	0.6	1.5	-0.9	-1.2	-0.1	-0.2
Average weekly champagne plus white wine intake	0.3	0.4	0.7	0.8	0.2	0.8	0.6
Medication: Blood pressure	0.3	0.6	1.8	-1.3	0.6	-0.4	-0.2
High cholesterol (Self-reported)	0.3	0.6	1.3	0.7	0.2	0.8	1.1
Medication: Atorvastatin	0.3	0.3	0.6	0.3	-0.4	0.7	0.8
Irritability	0.3	0.4	0.6	0.4	0.6	0.8	0.7
Diastolic blood pressure, automated reading	0.3	0.9	3.3	-0.3	1.8	0.2	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.1	0.9	0.3	1.5	0.9
Cholesterol lowering medication	0.3	0.4	1.0	1.0	0.2	0.0	0.8
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.2	0.6	-1.1	0.2	0.7
Ulcerative Colitis (UC)	0.2	0.3	0.5	0.7	-0.2	0.5	0.7
Major Depression (MDD)	0.2	0.2	0.3	0.5	0.0	0.6	0.4
Mean Putamen Volume	0.2	0.3	0.7	-0.4	0.8	0.5	0.2
LDL Cholesterol	0.2	0.2	0.6	0.4	0.3	0.7	0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	0.3	-0.4	0.6	0.3
Blood Red Count	0.2	1.6	3.5	1.9	0.3	1.1	1.3
Heel T-Score	0.2	1.3	3.3	-0.4	1.8	1.3	0.2
Smoking Status	0.2	0.6	1.3	1.1	-0.8	-0.4	-0.4
Cardiovascular Disease	0.2	0.7	1.2	-0.6	1.0	-1.1	-0.6
Hair Pigment	0.2	6.3	8.5	-2.7	-2.5	-1.9	-2.9
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.4	0.5	0.5	0.3	0.6
Supplements: Zinc	0.2	0.2	0.4	0.6	-0.0	-0.3	0.5
Taking other prescription medications	0.2	0.3	0.9	0.1	-0.2	0.9	0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.9	0.1	-0.3	0.3	0.9
High blood pressure	0.2	0.5	1.3	-0.6	0.4	-1.1	-0.6
Medication: Levothyroxine sodium	0.2	0.4	0.6	0.7	0.8	-0.3	-0.5
Hair/balding pattern: Pattern 2	0.2	0.3	0.9	-1.0	0.2	-0.5	-0.1
Had other major operations	0.2	0.2	0.3	0.4	-0.4	0.5	0.4
Mouth/teeth dental problems	0.2	0.3	0.6	-0.6	0.6	0.7	0.2
Father’s age at death	0.2	0.3	0.7	-0.2	-0.6	0.8	0.5
Falls in the last year	0.2	0.3	0.8	0.1	-0.9	0.4	0.3
Medication: Cholesterol lowering	0.2	0.3	1.0	-0.5	-1.0	0.1	0.2
Gout (self-reported)	0.2	0.2	0.5	-0.2	-0.7	-0.6	0.1
High blood pressure (siblings)	0.2	0.2	0.4	0.3	0.6	-0.6	0.0
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	-0.1	0.3	-0.5	-0.7
Medication for pain relief, constipation, heartburn	0.2	0.3	1.2	-1.1	0.1	0.2	-0.2
Hypertension (Self-reported)	0.2	0.6	0.7	-0.8	0.8	-0.8	-0.5
Average weekly red wine intake	0.2	0.3	0.6	-0.2	0.7	-0.7	-0.3
Diabetes diagnosed by doctor	0.2	0.3	0.7	0.3	-0.8	-0.4	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	0.7	0.4	-0.4	-0.1
Breast cancer (self-reported)	0.2	0.3	0.5	-0.4	-0.4	-0.7	-0.5
Medication: Gliclazide	0.2	0.2	0.4	-0.4	0.6	0.3	-0.5
Alcohol drinker status: Previous	0.2	0.2	0.5	-0.3	-0.5	-0.7	-0.4
Pack years of smoking	0.2	0.3	0.6	0.8	-0.6	0.0	0.5
Depression (Nagel 2018)	0.1	0.1	0.4	0.4	-0.1	-0.6	-0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.1	0.3	-0.1	-0.3
Triglycerides	0.1	0.2	0.3	0.6	-0.1	0.1	0.6
Waist Hip Ratio (WHR)	0.1	0.5	1.0	-0.5	1.0	0.8	0.4
Tanning	0.1	1.8	2.1	1.0	1.4	1.5	1.4
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.1	-0.5	-0.2	0.0
Medication: Metformin	0.1	0.1	0.2	-0.4	-0.3	-0.3	0.0
Severe depression (siblings)	0.1	0.1	0.2	-0.4	0.4	-0.1	0.1
Qualifications: CSEs or equivalent	0.1	0.2	0.3	-0.6	0.5	-0.2	-0.4
Medication: Atenolol	0.1	0.2	0.3	-0.1	0.3	-0.6	0.4
Allergy	0.1	0.2	0.6	0.2	0.8	0.3	0.0
Pulse rate	0.1	0.1	0.3	0.1	0.6	-0.3	0.1
Asthma	0.1	0.2	0.5	-0.7	-0.3	-0.4	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	-0.2	-0.3	-0.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.1	0.0	0.5	0.5
Hair/balding pattern: Pattern 4	0.1	0.3	0.8	-0.1	0.9	0.7	-0.1
Blood clot in the leg (DVT)	0.1	0.1	0.5	-0.1	-0.1	0.7	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.4	0.4	0.6	0.5
Number of full brothers	0.1	0.1	0.3	-0.3	-0.6	0.2	0.2
Eye problems/disorders: None of the above	0.1	0.1	0.1	0.3	0.4	0.1	-0.0
Pulse rate, automated reading	0.1	0.3	0.6	-0.6	-0.8	-0.6	-0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.4	-0.5	0.1	-0.1
Loneliness, isolation	0.1	0.1	0.2	0.4	0.3	0.3	0.2
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.2	-0.0	0.4	0.1
Medication for cholesterol	0.1	0.1	0.2	0.4	-0.2	0.2	-0.4
Asthma (self-reported)	0.1	0.3	0.6	-0.8	-0.4	-0.4	-0.4
Osteoporosis (self-reported)	0.1	0.1	0.2	-0.2	-0.2	0.4	0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.5	0.4	-0.4	-0.1
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.6	0.5	-0.1	-0.0
Medication: Lisinopril	0.1	0.1	0.2	-0.5	-0.0	-0.4	-0.4
Number of operations (self-reported)	0.1	0.1	0.3	0.5	0.0	0.3	0.3
Pain experienced in last month	0.1	0.2	0.4	-0.4	0.3	0.7	0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.6	-0.3	0.1	0.8	-0.2
Heart disease (siblings)	0.1	0.1	0.3	-0.2	0.1	-0.6	0.1
Hearing difficulty/problems: Yes	0.0	0.1	0.2	0.2	-0.1	-0.5	0.0
Diabetes (self-reported)	0.0	0.0	0.1	0.1	-0.3	-0.1	0.2
Hayfever/allergic rhinitis (self-reported)	0.0	0.1	0.2	-0.1	-0.4	-0.0	-0.1
Medication: Lansoprazole	0.0	0.0	0.1	-0.2	0.1	0.2	0.3
Medication: Amlodipine	0.0	0.0	0.1	-0.2	-0.2	0.3	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	-0.3	-0.1	-0.2	-0.1

Hub : Genes

USP33

Models

Trait associations