[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr1:91,800,946-94,294,492

Best TWAS P=2.93e-25 · Best GWAS P=5.32e-75 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
50	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EVI5	0.05	0.02	blup	96	0.03	2.3e-03	8.8	10.4	2.9e-25	0.03	0.07	0.78	TRUE
42	The Cancer Genome Atlas	Glioblastoma Multiforme	EVI5	0.14	0.04	blup	93	0.06	8.9e-03	8.3	9.8	1.5e-22	-0.01	0.07	0.36	TRUE
4	CommonMind	Brain Pre-frontal Cortex	FAM69A	0.10	0.13	lasso	4	0.14	1.2e-16	7.9	8.7	2.8e-18	0.07	0.99	0.01	TRUE
15	GTEx	Cells Transformed fibroblasts	EVI5	0.18	0.11	enet	28	0.20	5.9e-15	9.1	8.7	4.0e-18	0.01	0.13	0.87	TRUE
53	The Cancer Genome Atlas	Stomach Adenocarcinoma	EVI5	0.14	0.07	lasso	3	0.08	3.4e-06	8.3	8.2	2.6e-16	0.04	0.35	0.62	TRUE
34	METSIM	Adipose	EVI5	0.14	0.10	enet	35	0.11	1.0e-15	8.3	6.9	4.8e-12	0.04	0.26	0.74	TRUE
2	CommonMind	Brain Pre-frontal Cortex	EPHX4	0.05	0.04	enet	15	0.04	3.8e-06	-6.5	6.6	5.2e-11	0.00	0.42	0.02	TRUE
1	CommonMind	Brain Pre-frontal Cortex	BTBD8	0.06	0.00	bslmm	441	0.02	1.3e-03	-7.3	5.3	1.1e-07	0.28	0.05	0.07	TRUE
9	GTEx	Artery Tibial	EVI5	0.08	0.08	lasso	10	0.12	9.5e-10	9.6	10.1	7.2e-24	0.00	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EVI5	0.04	0.04	blup	93	0.03	4.8e-04	8.4	10.0	2.0e-23	0.02	0.26	0.65	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	EVI5	0.06	0.10	blup	94	0.10	1.7e-10	8.0	9.9	3.5e-23	0.01	0.61	0.39	FALSE
46	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EVI5	0.04	0.02	blup	96	0.04	1.4e-03	8.4	9.9	3.7e-23	0.00	0.08	0.19	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EVI5	0.08	0.04	blup	96	0.06	8.6e-08	8.3	9.8	8.6e-23	0.02	0.25	0.75	FALSE
51	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EVI5	0.10	0.06	blup	94	0.08	2.9e-04	8.0	9.8	1.3e-22	0.02	0.03	0.92	FALSE
40	The Cancer Genome Atlas	Colon Adenocarcinoma	EVI5	0.07	0.04	blup	93	0.03	4.7e-03	8.7	9.7	4.0e-22	0.06	0.12	0.38	FALSE
32	GTEx	Uterus	EVI5	0.23	0.12	enet	27	0.16	4.3e-04	8.0	9.7	4.5e-22	0.02	0.04	0.88	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	EVI5	0.05	0.07	lasso	5	0.07	5.6e-09	8.3	9.4	4.4e-21	0.03	0.14	0.86	FALSE
33	GTEx	Whole Blood	EVI5	0.03	0.01	lasso	2	0.01	6.8e-02	8.0	9.2	3.9e-20	0.00	0.05	0.93	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	EVI5	0.22	0.10	lasso	7	0.06	2.3e-03	8.4	9.2	4.3e-20	0.03	0.24	0.72	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	FAM69A	0.10	0.13	lasso	4	0.15	2.4e-19	7.2	9.1	7.5e-20	0.06	0.97	0.03	FALSE
25	GTEx	Nerve Tibial	EVI5	0.17	0.13	enet	25	0.18	4.5e-13	8.3	9.1	9.6e-20	0.03	0.32	0.68	FALSE
10	GTEx	Brain Caudate basal ganglia	EVI5	0.10	0.00	enet	19	0.01	1.7e-01	8.0	9.0	2.9e-19	-0.02	0.10	0.20	FALSE
19	GTEx	Esophagus Mucosa	EVI5	0.12	0.19	lasso	4	0.19	6.0e-13	8.4	8.9	6.9e-19	0.03	0.52	0.48	FALSE
6	GTEx	Adipose Subcutaneous	EVI5	0.09	0.07	lasso	3	0.09	1.2e-07	7.9	8.8	9.0e-19	0.09	0.27	0.73	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	EVI5	0.03	0.03	lasso	4	0.04	3.6e-09	8.3	8.8	1.6e-18	0.02	0.32	0.68	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	EVI5	0.18	0.16	lasso	7	0.15	2.0e-16	8.0	8.8	2.2e-18	-0.01	0.83	0.17	FALSE
20	GTEx	Esophagus Muscularis	EVI5	0.16	0.23	lasso	5	0.23	4.9e-14	8.4	8.7	3.2e-18	0.06	0.36	0.64	FALSE
23	GTEx	Lung	EVI5	0.11	0.08	lasso	11	0.13	7.0e-10	8.9	8.6	9.3e-18	0.03	0.29	0.71	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FAM69A	0.05	0.03	blup	62	0.05	4.4e-06	8.0	8.5	2.3e-17	0.10	0.25	0.71	FALSE
3	CommonMind	Brain Pre-frontal Cortex	EVI5	0.03	0.01	blup	335	0.02	1.3e-03	8.0	8.4	5.3e-17	0.01	0.04	0.92	FALSE
22	GTEx	Heart Left Ventricle	EVI5	0.07	0.11	lasso	5	0.08	7.7e-05	8.0	8.3	7.2e-17	-0.01	0.21	0.75	FALSE
7	GTEx	Adipose Visceral Omentum	EVI5	0.13	0.08	lasso	2	0.07	2.3e-04	8.4	8.3	9.6e-17	0.05	0.26	0.52	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EVI5	0.07	0.05	blup	96	0.06	2.5e-07	8.3	8.2	2.2e-16	0.04	0.31	0.69	FALSE
21	GTEx	Heart Atrial Appendage	EVI5	0.09	0.06	lasso	7	0.05	4.2e-03	8.0	8.2	2.8e-16	-0.03	0.24	0.44	FALSE
35	METSIM	Adipose	FAM69A	0.03	0.03	bslmm	293	0.02	1.8e-03	8.8	-8.1	4.0e-16	-0.09	0.50	0.26	FALSE
8	GTEx	Artery Coronary	EVI5	0.09	0.10	lasso	2	0.07	3.1e-03	8.0	8.0	9.4e-16	0.09	0.11	0.50	FALSE
13	GTEx	Breast Mammary Tissue	EVI5	0.07	0.06	lasso	4	0.07	2.3e-04	8.0	8.0	1.0e-15	-0.02	0.13	0.83	FALSE
16	GTEx	Colon Sigmoid	EVI5	0.13	0.16	lasso	3	0.12	7.0e-05	8.0	8.0	1.2e-15	-0.03	0.29	0.64	FALSE
28	GTEx	Spleen	EVI5	0.21	0.15	enet	22	0.25	3.3e-07	7.6	8.0	1.3e-15	0.04	0.10	0.86	FALSE
11	GTEx	Brain Cortex	EVI5	0.25	0.33	lasso	13	0.30	4.1e-09	8.0	8.0	1.7e-15	-0.02	0.24	0.76	FALSE
12	GTEx	Brain Hypothalamus	EVI5	0.16	0.12	lasso	13	0.05	2.1e-02	8.0	7.8	9.1e-15	-0.03	0.07	0.51	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	EVI5	0.07	0.05	lasso	6	0.08	2.2e-05	8.3	7.7	1.7e-14	0.03	0.09	0.89	FALSE
41	The Cancer Genome Atlas	Colon Adenocarcinoma	FAM69A	0.05	0.01	enet	7	0.02	3.6e-02	7.5	7.5	4.9e-14	0.08	0.06	0.12	FALSE
17	GTEx	Colon Transverse	EVI5	0.21	0.08	lasso	9	0.14	4.2e-07	2.6	7.5	6.1e-14	0.04	0.05	0.94	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	EVI5	0.05	0.01	blup	94	0.03	5.7e-04	9.0	-7.5	7.5e-14	-0.10	0.13	0.60	FALSE
38	YFS	Blood	MTF2	0.02	0.00	enet	14	0.02	2.4e-06	-2.0	6.8	8.2e-12	-0.02	0.16	0.77	FALSE
30	GTEx	Thyroid	RPAP2	0.04	0.03	enet	15	0.03	4.2e-03	-5.2	6.8	8.7e-12	0.09	0.18	0.35	FALSE
14	GTEx	Breast Mammary Tissue (Male)	EVI5	0.17	0.03	lasso	10	0.08	5.9e-03	9.6	6.8	1.5e-11	-0.01	0.03	0.68	FALSE
29	GTEx	Stomach	EVI5	0.12	0.13	lasso	6	0.14	4.7e-07	8.4	6.7	2.3e-11	0.06	0.42	0.57	FALSE
5	CommonMind	Brain Pre-frontal Cortex	RPAP2	0.20	0.06	enet	29	0.16	8.6e-19	9.0	6.6	3.2e-11	0.04	0.02	0.98	FALSE
37	YFS	Blood	FAM69A	0.28	0.09	enet	29	0.13	4.9e-40	-4.3	-6.5	5.7e-11	0.01	1.00	0.00	FALSE
31	GTEx	Thyroid	FAM69A	0.43	0.18	enet	41	0.20	5.5e-15	-4.3	-6.4	1.7e-10	0.02	1.00	0.00	FALSE
26	GTEx	Pancreas	FAM69A	0.10	0.08	enet	12	0.04	1.1e-02	7.9	5.8	5.4e-09	0.05	0.24	0.09	FALSE
24	GTEx	Lung	RPAP2	0.08	0.04	enet	27	0.06	1.0e-05	-6.7	5.4	7.2e-08	-0.01	0.48	0.30	FALSE