Best TWAS P=1.9e-22 · Best GWAS P=3.19e-22 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FGL1 | 0.15 | 0.10 | enet | 23 | 0.14 | 7.4e-17 | -6.2 | -5.6 | 2.1e-08 | 0.01 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | MTUS1 | 0.28 | 0.14 | enet | 65 | 0.21 | 3.2e-25 | -5.3 | 5.4 | 6.7e-08 | -0.05 | 1.00 | 0.00 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | PCM1 | 0.20 | 0.16 | lasso | 5 | 0.19 | 2.4e-22 | -7.8 | -7.3 | 3.8e-13 | 0.01 | 0.81 | 0.19 | FALSE |
| 4 | GTEx | Artery Aorta | PCM1 | 0.21 | 0.14 | lasso | 4 | 0.12 | 3.9e-07 | -8.6 | -8.6 | 6.1e-18 | 0.00 | 0.25 | 0.74 | TRUE |
| 5 | GTEx | Artery Tibial | PCM1 | 0.28 | 0.16 | enet | 23 | 0.19 | 8.7e-15 | -8.6 | -5.8 | 5.6e-09 | 0.00 | 0.77 | 0.23 | FALSE |
| 6 | GTEx | Brain Caudate basal ganglia | PCM1 | 0.35 | 0.35 | lasso | 2 | 0.34 | 1.0e-10 | -7.8 | -7.3 | 3.5e-13 | 0.01 | 0.76 | 0.18 | FALSE |
| 7 | GTEx | Brain Cerebellar Hemisphere | PCM1 | 0.64 | 0.44 | lasso | 7 | 0.43 | 3.4e-12 | -7.8 | -7.7 | 1.1e-14 | 0.00 | 0.82 | 0.16 | TRUE |
| 8 | GTEx | Brain Cerebellar Hemisphere | ASAH1 | 0.33 | 0.22 | enet | 22 | 0.25 | 4.4e-07 | 8.1 | 8.9 | 6.7e-19 | 0.02 | 0.25 | 0.65 | FALSE |
| 9 | GTEx | Brain Cerebellum | PCM1 | 0.80 | 0.30 | lasso | 21 | 0.43 | 4.7e-14 | -7.8 | -5.9 | 3.7e-09 | -0.01 | 0.97 | 0.02 | FALSE |
| 10 | GTEx | Brain Cerebellum | ASAH1 | 0.44 | 0.14 | enet | 40 | 0.24 | 1.0e-07 | -8.2 | 7.5 | 8.7e-14 | 0.04 | 0.69 | 0.24 | FALSE |
| 11 | GTEx | Brain Cortex | PCM1 | 0.46 | 0.44 | lasso | 5 | 0.44 | 9.9e-14 | -7.8 | -7.6 | 2.1e-14 | 0.00 | 0.89 | 0.10 | FALSE |
| 12 | GTEx | Brain Frontal Cortex BA9 | PCM1 | 0.46 | 0.28 | lasso | 16 | 0.21 | 2.9e-06 | -7.8 | -7.9 | 2.2e-15 | -0.01 | 0.32 | 0.58 | TRUE |
| 13 | GTEx | Brain Hypothalamus | PCM1 | 0.29 | 0.29 | lasso | 3 | 0.26 | 8.4e-07 | -7.8 | -7.8 | 6.1e-15 | 0.01 | 0.23 | 0.36 | FALSE |
| 14 | GTEx | Brain Nucleus accumbens basal ganglia | PCM1 | 0.32 | 0.06 | lasso | 5 | 0.07 | 5.2e-03 | -7.8 | -7.4 | 1.1e-13 | 0.00 | 0.14 | 0.44 | FALSE |
| 15 | GTEx | Cells Transformed fibroblasts | PCM1 | 0.10 | 0.12 | lasso | 2 | 0.10 | 7.4e-08 | -8.5 | -8.5 | 1.7e-17 | 0.00 | 0.64 | 0.36 | FALSE |
| 16 | GTEx | Colon Sigmoid | PCM1 | 0.32 | 0.12 | lasso | 5 | 0.11 | 1.4e-04 | -7.6 | -8.2 | 2.1e-16 | 0.03 | 0.28 | 0.63 | FALSE |
| 17 | GTEx | Esophagus Gastroesophageal Junction | MICU3 | 0.34 | 0.00 | lasso | 8 | 0.04 | 1.8e-02 | -1.1 | 7.1 | 1.3e-12 | 0.50 | 0.02 | 0.78 | TRUE |
| 18 | GTEx | Esophagus Mucosa | ASAH1 | 0.32 | 0.15 | enet | 17 | 0.22 | 9.3e-15 | -4.3 | 5.5 | 3.4e-08 | 0.09 | 1.00 | 0.00 | TRUE |
| 19 | GTEx | Esophagus Muscularis | ASAH1 | 0.24 | 0.11 | lasso | 9 | 0.11 | 3.1e-07 | -3.4 | 5.6 | 2.6e-08 | 0.09 | 0.90 | 0.05 | FALSE |
| 20 | GTEx | Heart Left Ventricle | PDGFRL | 0.15 | 0.05 | enet | 7 | 0.07 | 1.1e-04 | -5.1 | 6.3 | 2.2e-10 | -0.05 | 0.62 | 0.02 | FALSE |
| 21 | GTEx | Lung | PCM1 | 0.08 | 0.00 | enet | 13 | 0.01 | 6.9e-02 | -7.8 | -9.2 | 2.7e-20 | -0.02 | 0.05 | 0.88 | FALSE |
| 22 | GTEx | Muscle Skeletal | PCM1 | 0.10 | 0.08 | lasso | 5 | 0.09 | 2.4e-09 | 8.1 | -8.9 | 4.4e-19 | -0.01 | 0.46 | 0.54 | FALSE |
| 23 | GTEx | Thyroid | ASAH1 | 0.20 | 0.12 | lasso | 3 | 0.11 | 1.4e-08 | -7.8 | -7.2 | 4.3e-13 | 0.03 | 0.93 | 0.07 | FALSE |
| 24 | GTEx | Vagina | PCM1 | 0.52 | 0.16 | lasso | 13 | 0.06 | 2.0e-02 | -8.5 | -8.1 | 5.4e-16 | 0.01 | 0.09 | 0.57 | TRUE |
| 25 | GTEx | Vagina | ASAH1 | 0.63 | 0.12 | lasso | 9 | 0.13 | 8.3e-04 | -5.3 | 9.4 | 6.3e-21 | -0.03 | 0.12 | 0.20 | TRUE |
| 26 | GTEx | Whole Blood | ASAH1 | 0.14 | 0.16 | enet | 14 | 0.15 | 1.0e-13 | -7.0 | -7.4 | 1.9e-13 | 0.00 | 1.00 | 0.00 | FALSE |
| 27 | METSIM | Adipose | MICU3 | 0.06 | 0.04 | enet | 10 | 0.03 | 9.0e-05 | -3.5 | 5.5 | 4.3e-08 | 0.53 | 0.08 | 0.91 | TRUE |
| 28 | NTR | Blood | ASAH1 | 0.09 | 0.09 | enet | 37 | 0.10 | 3.6e-29 | -7.0 | -8.0 | 1.5e-15 | 0.00 | 1.00 | 0.00 | FALSE |
| 29 | ROSMAP | Brain Pre-frontal Cortex | PCM1 | 0.28 | 0.38 | bslmm | 884 | 0.39 | 6.5e-53 | -7.8 | -9.1 | 7.7e-20 | 0.00 | 0.90 | 0.10 | FALSE |
| 30 | ROSMAP | Brain Pre-frontal Cortex | FGL1 | 0.23 | 0.17 | lasso | 12 | 0.22 | 7.5e-28 | -7.7 | -6.8 | 1.4e-11 | 0.00 | 0.98 | 0.02 | FALSE |
| 31 | ROSMAP | Brain Pre-frontal Cortex | ASAH1 | 0.13 | 0.15 | enet | 19 | 0.16 | 1.8e-20 | -8.4 | 9.6 | 6.8e-22 | 0.01 | 0.57 | 0.43 | FALSE |
| 32 | ROSMAP | Brain Pre-frontal Cortex | RP11-806O11.1 | 0.10 | 0.10 | lasso | 8 | 0.10 | 1.8e-12 | -7.6 | -7.1 | 1.1e-12 | 0.05 | 0.91 | 0.09 | TRUE |
| 33 | YFS | Blood | ASAH1 | 0.05 | 0.05 | bslmm | 835 | 0.04 | 1.5e-14 | -8.2 | -7.9 | 4.1e-15 | -0.02 | 0.98 | 0.02 | FALSE |
| 34 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FGL1 | 0.03 | 0.00 | lasso | 6 | 0.01 | 4.2e-03 | -9.1 | 8.6 | 7.3e-18 | -0.01 | 0.02 | 0.92 | FALSE |
| 35 | The Cancer Genome Atlas | Esophageal Carcinoma | PCM1 | 0.25 | 0.16 | blup | 164 | 0.10 | 3.2e-04 | -9.1 | -9.4 | 7.9e-21 | -0.02 | 0.02 | 0.96 | FALSE |
| 36 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ASAH1 | 0.03 | 0.02 | blup | 116 | 0.01 | 9.4e-03 | 8.1 | 9.7 | 1.9e-22 | 0.02 | 0.09 | 0.72 | TRUE |
| 37 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MTUS1 | 0.08 | 0.07 | lasso | 4 | 0.09 | 5.4e-10 | -5.5 | 5.9 | 4.3e-09 | -0.06 | 1.00 | 0.00 | FALSE |
| 38 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PCM1 | 0.03 | 0.02 | lasso | 3 | 0.01 | 3.0e-02 | -9.1 | -8.7 | 4.1e-18 | -0.01 | 0.02 | 0.82 | FALSE |
| 39 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PCM1 | 0.06 | 0.02 | blup | 164 | 0.04 | 1.2e-03 | -9.1 | -7.7 | 1.7e-14 | -0.02 | 0.04 | 0.79 | FALSE |
| 40 | The Cancer Genome Atlas | Thyroid Carcinoma | EFHA2 | 0.05 | 0.01 | lasso | 2 | 0.02 | 7.9e-03 | 6.8 | 6.7 | 2.7e-11 | 0.68 | 0.20 | 0.74 | FALSE |
| 41 | The Cancer Genome Atlas | Thyroid Carcinoma | PCM1 | 0.10 | 0.04 | blup | 165 | 0.05 | 2.1e-05 | -8.5 | -9.5 | 3.3e-21 | -0.01 | 0.05 | 0.95 | FALSE |