[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr8:16,188,310-18,638,660

Best TWAS P=1.9e-22 · Best GWAS P=3.19e-22 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	ASAH1	0.03	0.02	blup	116	0.01	9.4e-03	8.1	9.7	1.9e-22	0.02	0.09	0.72	TRUE
25	GTEx	Vagina	ASAH1	0.63	0.12	lasso	9	0.13	8.3e-04	-5.3	9.4	6.3e-21	-0.03	0.12	0.20	TRUE
4	GTEx	Artery Aorta	PCM1	0.21	0.14	lasso	4	0.12	3.9e-07	-8.6	-8.6	6.1e-18	0.00	0.25	0.74	TRUE
24	GTEx	Vagina	PCM1	0.52	0.16	lasso	13	0.06	2.0e-02	-8.5	-8.1	5.4e-16	0.01	0.09	0.57	TRUE
12	GTEx	Brain Frontal Cortex BA9	PCM1	0.46	0.28	lasso	16	0.21	2.9e-06	-7.8	-7.9	2.2e-15	-0.01	0.32	0.58	TRUE
7	GTEx	Brain Cerebellar Hemisphere	PCM1	0.64	0.44	lasso	7	0.43	3.4e-12	-7.8	-7.7	1.1e-14	0.00	0.82	0.16	TRUE
32	ROSMAP	Brain Pre-frontal Cortex	RP11-806O11.1	0.10	0.10	lasso	8	0.10	1.8e-12	-7.6	-7.1	1.1e-12	0.05	0.91	0.09	TRUE
17	GTEx	Esophagus Gastroesophageal Junction	MICU3	0.34	0.00	lasso	8	0.04	1.8e-02	-1.1	7.1	1.3e-12	0.50	0.02	0.78	TRUE
18	GTEx	Esophagus Mucosa	ASAH1	0.32	0.15	enet	17	0.22	9.3e-15	-4.3	5.5	3.4e-08	0.09	1.00	0.00	TRUE
27	METSIM	Adipose	MICU3	0.06	0.04	enet	10	0.03	9.0e-05	-3.5	5.5	4.3e-08	0.53	0.08	0.91	TRUE
31	ROSMAP	Brain Pre-frontal Cortex	ASAH1	0.13	0.15	enet	19	0.16	1.8e-20	-8.4	9.6	6.8e-22	0.01	0.57	0.43	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	PCM1	0.10	0.04	blup	165	0.05	2.1e-05	-8.5	-9.5	3.3e-21	-0.01	0.05	0.95	FALSE
35	The Cancer Genome Atlas	Esophageal Carcinoma	PCM1	0.25	0.16	blup	164	0.10	3.2e-04	-9.1	-9.4	7.9e-21	-0.02	0.02	0.96	FALSE
21	GTEx	Lung	PCM1	0.08	0.00	enet	13	0.01	6.9e-02	-7.8	-9.2	2.7e-20	-0.02	0.05	0.88	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	PCM1	0.28	0.38	bslmm	884	0.39	6.5e-53	-7.8	-9.1	7.7e-20	0.00	0.90	0.10	FALSE
22	GTEx	Muscle Skeletal	PCM1	0.10	0.08	lasso	5	0.09	2.4e-09	8.1	-8.9	4.4e-19	-0.01	0.46	0.54	FALSE
8	GTEx	Brain Cerebellar Hemisphere	ASAH1	0.33	0.22	enet	22	0.25	4.4e-07	8.1	8.9	6.7e-19	0.02	0.25	0.65	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	PCM1	0.03	0.02	lasso	3	0.01	3.0e-02	-9.1	-8.7	4.1e-18	-0.01	0.02	0.82	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	FGL1	0.03	0.00	lasso	6	0.01	4.2e-03	-9.1	8.6	7.3e-18	-0.01	0.02	0.92	FALSE
15	GTEx	Cells Transformed fibroblasts	PCM1	0.10	0.12	lasso	2	0.10	7.4e-08	-8.5	-8.5	1.7e-17	0.00	0.64	0.36	FALSE
16	GTEx	Colon Sigmoid	PCM1	0.32	0.12	lasso	5	0.11	1.4e-04	-7.6	-8.2	2.1e-16	0.03	0.28	0.63	FALSE
28	NTR	Blood	ASAH1	0.09	0.09	enet	37	0.10	3.6e-29	-7.0	-8.0	1.5e-15	0.00	1.00	0.00	FALSE
33	YFS	Blood	ASAH1	0.05	0.05	bslmm	835	0.04	1.5e-14	-8.2	-7.9	4.1e-15	-0.02	0.98	0.02	FALSE
13	GTEx	Brain Hypothalamus	PCM1	0.29	0.29	lasso	3	0.26	8.4e-07	-7.8	-7.8	6.1e-15	0.01	0.23	0.36	FALSE
39	The Cancer Genome Atlas	Stomach Adenocarcinoma	PCM1	0.06	0.02	blup	164	0.04	1.2e-03	-9.1	-7.7	1.7e-14	-0.02	0.04	0.79	FALSE
11	GTEx	Brain Cortex	PCM1	0.46	0.44	lasso	5	0.44	9.9e-14	-7.8	-7.6	2.1e-14	0.00	0.89	0.10	FALSE
10	GTEx	Brain Cerebellum	ASAH1	0.44	0.14	enet	40	0.24	1.0e-07	-8.2	7.5	8.7e-14	0.04	0.69	0.24	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	PCM1	0.32	0.06	lasso	5	0.07	5.2e-03	-7.8	-7.4	1.1e-13	0.00	0.14	0.44	FALSE
26	GTEx	Whole Blood	ASAH1	0.14	0.16	enet	14	0.15	1.0e-13	-7.0	-7.4	1.9e-13	0.00	1.00	0.00	FALSE
6	GTEx	Brain Caudate basal ganglia	PCM1	0.35	0.35	lasso	2	0.34	1.0e-10	-7.8	-7.3	3.5e-13	0.01	0.76	0.18	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PCM1	0.20	0.16	lasso	5	0.19	2.4e-22	-7.8	-7.3	3.8e-13	0.01	0.81	0.19	FALSE
23	GTEx	Thyroid	ASAH1	0.20	0.12	lasso	3	0.11	1.4e-08	-7.8	-7.2	4.3e-13	0.03	0.93	0.07	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	FGL1	0.23	0.17	lasso	12	0.22	7.5e-28	-7.7	-6.8	1.4e-11	0.00	0.98	0.02	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	EFHA2	0.05	0.01	lasso	2	0.02	7.9e-03	6.8	6.7	2.7e-11	0.68	0.20	0.74	FALSE
20	GTEx	Heart Left Ventricle	PDGFRL	0.15	0.05	enet	7	0.07	1.1e-04	-5.1	6.3	2.2e-10	-0.05	0.62	0.02	FALSE
9	GTEx	Brain Cerebellum	PCM1	0.80	0.30	lasso	21	0.43	4.7e-14	-7.8	-5.9	3.7e-09	-0.01	0.97	0.02	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTUS1	0.08	0.07	lasso	4	0.09	5.4e-10	-5.5	5.9	4.3e-09	-0.06	1.00	0.00	FALSE
5	GTEx	Artery Tibial	PCM1	0.28	0.16	enet	23	0.19	8.7e-15	-8.6	-5.8	5.6e-09	0.00	0.77	0.23	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FGL1	0.15	0.10	enet	23	0.14	7.4e-17	-6.2	-5.6	2.1e-08	0.01	1.00	0.00	FALSE
19	GTEx	Esophagus Muscularis	ASAH1	0.24	0.11	lasso	9	0.11	3.1e-07	-3.4	5.6	2.6e-08	0.09	0.90	0.05	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MTUS1	0.28	0.14	enet	65	0.21	3.2e-25	-5.3	5.4	6.7e-08	-0.05	1.00	0.00	FALSE