TWAS hub - SBSPON

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.162	0.0497	5.3e-04	0.153	NA	0.155	NA	0.151	4.9e-12	NA	3.6e-12	NA	6.7e-12
2	GTEx	Esophagus Mucosa	0.130	0.0450	8.0e-04	0.027	NA	0.121	NA	0.065	6.5e-03	NA	1.8e-08	NA	3.9e-05
3	GTEx	Lung	0.159	0.0550	1.4e-03	0.101	NA	0.087	NA	0.088	3.8e-08	NA	3.7e-07	NA	2.9e-07
4	GTEx	Nerve Tibial	0.359	0.0640	6.0e-07	0.128	NA	0.179	NA	0.206	2.5e-09	NA	1.1e-12	NA	1.4e-14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Alcohol usually taken with meals	4.5	7.2	15.3	-3.4	-3.9	-1.3	-0.5
Diabetes (mother)	4.4	5.6	11.8	-0.9	-3.4	-3.1	0.2
Commuting to job workplace: Cycle	3.4	4.2	10.0	-1.5	-1.7	-1.3	-3.2
Emphysema/chronic bronchitis	3.3	3.7	8.6	-0.1	2.5	2.9	-0.5
Peak expiratory flow (PEF)	3.2	7.5	21.3	-0.6	-2.8	-4.6	-0.7
Pulse wave reflection index	3.1	3.8	8.0	-1.3	-2.8	-1.3	-1.9
Chronic bronchitis/emphysema (mother)	3.1	3.6	11.6	1.2	1.1	0.3	3.4
Eye problems/disorders: Glaucoma	3.0	3.6	9.9	-1.4	-1.5	-0.3	-3.1
Medication for hormone replacement therapy	2.8	3.1	8.0	-1.1	-2.8	-1.6	0.7
Pulse rate	2.7	4.5	11.1	0.1	2.3	1.4	3.3
Had menopause	2.6	3.2	6.9	-1.8	0.7	2.6	-1.4
Mouth/teeth dental problems	2.6	3.9	11.7	-1.3	1.5	3.4	0.1
Glaucoma (self-reported)	2.6	3.0	5.2	-2.3	-1.7	0.1	-2.0
Medication: Aspirin	2.6	3.4	10.5	0.3	3.2	1.4	1.1
Medication: Aspirin	2.6	3.4	10.5	-0.1	3.2	1.3	1.2
Chronic bronchitis/emphysema (father)	2.4	2.8	5.2	-2.3	-1.4	1.6	-1.3
Lung FEV1/FVC ratio	2.3	11.5	39.2	2.4	-0.5	-6.3	0.8
Average weekly spirits intake	2.3	2.9	8.0	0.2	1.9	-0.2	2.8
Number of full brothers	2.2	2.8	8.9	1.3	-0.8	-3.0	-0.4
Depressed Affect (Nagel 2018)	2.1	4.4	13.2	1.9	3.6	0.4	-0.8
Guilty feelings	2.1	3.1	6.3	0.6	2.5	0.2	2.4
Supplements: Zinc	2.0	2.2	5.9	0.7	-0.5	-1.4	2.4
Townsend deprivation index at recruitment	2.0	2.8	7.6	0.7	-0.6	-1.6	-2.8
Qualifications: None of the above	2.0	4.3	8.0	1.4	2.7	2.8	0.3
Illnesses of mother	2.0	2.4	5.9	-1.7	-0.8	0.6	-2.4
Age at first live birth	1.9	3.4	7.5	-0.7	-2.4	-2.7	0.1
Medication: Blood pressure	1.9	3.3	6.4	2.5	1.7	0.0	2.0
Angina (self-reported)	1.9	2.6	3.4	1.0	1.8	1.6	1.8
Age at last live birth	1.9	2.8	6.6	0.2	-2.1	-2.6	-0.4
Supplements: Fish oil (including cod liver oil)	1.9	2.4	3.6	-1.9	1.7	1.7	-0.0
Angina	1.8	2.4	3.5	1.1	1.9	1.5	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	6.3	2.5	-0.3	-0.9	1.1
Serious illness, injury or assault to yourself	1.7	2.1	4.2	1.6	2.1	1.2	-0.2
Medication: Gliclazide	1.7	1.9	2.8	1.0	1.7	1.1	1.7
Neuroticism	1.6	3.8	10.6	1.0	3.3	1.4	1.3
Fluid intelligence score	1.6	3.4	9.6	-1.6	-3.1	-1.1	-0.5
Mouth/teeth dental problems: Dentures	1.6	2.7	6.6	1.6	-1.2	-2.6	0.3
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	5.7	-1.7	-2.4	-0.9	-0.9
Number of full sisters	1.6	2.0	3.9	2.0	1.7	-0.8	0.6
Had major operations	1.6	1.9	4.3	1.0	1.5	2.1	0.2
Average weekly red wine intake	1.6	2.4	5.7	0.3	-1.6	-2.4	1.0
Average weekly champagne plus white wine intake	1.6	2.2	4.4	-0.0	-1.9	-0.9	-2.1
Pain all over the body in last month	1.5	1.6	3.9	0.0	2.0	1.3	0.9
Medication: Ibuprofen	1.5	1.8	2.8	-0.1	-1.3	-1.7	-1.6
Myopia	1.5	2.2	2.7	-1.3	-1.6	-1.3	1.7
Major Depression (MDD)	1.4	1.8	4.6	-0.2	1.1	2.1	-1.1
Illnesses of siblings	1.4	1.9	5.8	1.2	0.7	0.1	-2.4
Wheeze or whistling in the chest in last year	1.4	2.5	5.0	-0.5	2.1	2.2	-0.0
Shortness of breath walking on level ground	1.4	1.6	5.9	0.8	2.4	-0.2	0.1
Migraine (self-reported)	1.4	1.7	4.3	2.1	-0.8	-1.2	0.6
Chest pain or discomfort	1.4	2.0	2.6	0.5	1.6	1.5	1.6
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.1	0.9	1.2	0.4	2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	6.4	0.0	-1.6	-2.5	-1.7
Mother’s age at death	1.4	1.8	3.1	-1.0	-1.5	-1.8	0.8
Heart attack/myocardial infarction (self-reported)	1.4	1.9	4.1	1.1	2.0	1.5	-0.0
Verbal and Numeric Reasoning (VNR)	1.3	3.1	9.0	-1.1	-3.0	-1.3	-0.8
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	3.5	0.8	-0.6	-1.9	1.1
Average weekly fortified wine intake	1.3	1.5	3.4	-1.3	-1.8	-0.9	0.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	5.1	0.7	1.4	-0.8	2.3
Loud music exposure frequency	1.3	1.4	3.6	1.2	1.9	-0.5	-0.4
Medication: Paracetamol	1.3	2.0	3.5	1.4	-0.2	-1.6	-1.9
Medication: Lisinopril	1.3	1.7	4.6	0.9	2.1	1.1	0.2
Diabetes (father)	1.2	1.5	3.7	1.9	0.9	0.0	1.1
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.7	0.1	-1.4	0.0	-1.9
Heart attack	1.2	1.6	3.6	1.1	1.9	1.2	0.1
Medication: Paracetamol	1.2	2.0	3.1	1.4	-0.4	-1.8	-1.8
Medication: Ventolin 100micrograms inhaler	1.2	1.6	4.9	-2.2	-0.7	0.9	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.5	0.1	-1.9	-1.4	0.1
Asthma (self-reported)	1.2	2.4	7.8	-1.0	0.2	2.8	1.0
Miserableness	1.2	2.1	6.2	1.2	2.5	0.2	-0.8
Age started oral contraceptive pill	1.2	1.5	3.4	-0.9	-0.3	1.3	-1.9
Prostate Cancer	1.1	1.6	3.5	1.0	1.9	1.3	-0.4
Lupus	1.1	1.6	4.6	1.1	2.1	-0.6	0.4
Rheumatoid Arthritis	1.1	1.5	2.7	-1.6	-1.2	-0.3	-1.3
Ever used hormone-replacement therapy (HRT)	1.1	1.5	3.6	-1.9	-1.4	-0.6	-0.1
Fed-up feelings	1.1	2.0	6.5	1.1	2.6	0.1	-0.6
Had other major operations	1.1	1.4	2.4	-1.6	-1.5	-0.9	-0.1
Falls in the last year	1.1	1.5	4.2	-1.0	-0.6	2.0	-0.5
Hair/balding pattern: Pattern 3	1.1	1.6	3.9	0.9	-1.3	-0.0	-2.0
Number of children fathered	1.1	1.3	4.1	0.3	2.0	0.4	-0.9
Heart disease (mother)	1.1	1.4	2.6	1.6	0.1	-1.2	1.2
Pulse rate, automated reading	1.1	3.7	12.7	-0.2	1.4	0.3	3.6
Medication: Atorvastatin	1.1	1.4	4.9	-0.4	0.6	2.2	-0.3
Alcohol drinker status: Never	1.1	1.3	3.5	-0.2	-1.0	-1.9	0.7
Supplements: Calcium	1.1	1.2	3.2	1.0	-0.7	-1.8	0.3
Intelligence (Savage-Jansen 2018)	1.0	3.2	9.4	-0.4	-3.1	-1.8	0.0
Fasting Glucose	1.0	1.2	3.7	-0.1	-0.3	-1.1	-1.9
Primary Biliary Cirrhosis	1.0	1.4	2.6	1.6	1.5	-0.1	0.9
Triglycerides	1.0	1.6	2.9	0.1	-1.7	-1.5	1.2
Respiratory disease	1.0	2.3	7.0	-0.6	1.3	2.6	0.4
Multivitamins +/- minerals	1.0	1.3	3.2	-1.3	-0.0	-0.3	1.8
Allergy	1.0	2.3	6.5	1.6	-0.5	-2.6	-0.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	2.0	0.2	-1.3	-1.4	-1.3
Pulse wave Arterial Stiffness index	1.0	1.1	2.9	1.0	0.1	-0.7	1.7
Overall health rating	1.0	2.1	3.3	1.3	1.8	1.5	1.1
Medication: Bendroflumethiazide	1.0	1.6	3.7	1.3	1.9	0.7	0.5
Neuroticism (Nagel 2018)	0.9	2.1	6.5	1.2	2.5	0.7	0.2
HDL Cholesterol	0.9	1.6	3.1	-0.3	0.8	1.6	-1.8
Hypothyroidism (self reported)	0.9	2.0	2.9	1.6	1.7	-0.4	1.6
Medication: Co-codamol	0.9	1.0	1.9	-0.4	1.4	1.4	0.1
Severe depression (siblings)	0.9	1.0	2.2	1.3	0.1	0.2	1.5
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.8	-0.7	-0.9	-1.7	-0.1
Hair/balding pattern: Pattern 2	0.9	1.2	2.7	0.5	-0.8	-1.1	1.7
Noisy workplace	0.9	1.1	3.3	1.0	1.8	0.5	0.2
Asthma	0.9	1.7	4.9	-0.8	0.1	2.2	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.2	-0.2	-1.1	-1.5	-1.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.6	-1.6	-1.5	-0.2	-1.1
Medication: Amlodipine	0.9	1.2	4.1	0.2	0.3	-0.8	2.0
High blood pressure (siblings)	0.9	1.3	2.0	-1.4	-1.2	-0.7	1.2
Pulse wave peak to peak time	0.9	1.1	2.9	-0.9	0.0	0.7	-1.7
Qualifications: College or University degree	0.9	3.0	6.2	-0.8	-2.5	-1.7	-1.5
Eye problems/disorders: None of the above	0.9	1.0	2.3	-1.5	-0.2	0.9	0.9
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.2	-0.2	-1.1	0.2	-1.8
Back pain experienced in last month	0.9	1.3	3.6	-0.0	-1.9	-1.1	-0.6
Wears glasses or contact lenses	0.9	1.0	2.5	-0.7	-0.8	-0.5	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	1.6	0.8	1.0	1.2	-1.0
Schizophrenia (2018)	0.8	1.6	5.1	2.3	0.7	-0.6	0.7
Lung FVC	0.8	4.1	7.2	-2.7	-1.5	1.2	-2.3
Medication: Metformin	0.8	1.2	2.5	0.7	0.9	1.6	0.9
Medication: Levothyroxine sodium	0.8	1.3	4.7	-0.1	0.6	0.3	2.2
Financial difficulties in last 2 years	0.8	1.1	1.9	0.5	-0.7	-1.4	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.9	0.2	-0.8	-1.4	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.9	1.1	1.7	0.3	-0.8
Birth weight of first child	0.8	1.4	3.5	-1.4	0.1	1.9	-0.5
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.0	1.4	-0.5	-1.1	-0.5
Health satisfaction	0.8	1.1	2.5	0.6	1.0	1.6	-0.6
Medication for pain relief, constipation, heartburn	0.8	1.4	2.4	-0.7	-1.4	0.9	1.6
Medication: Omeprazole	0.8	0.9	1.6	1.1	0.7	1.3	-0.5
Mean time to correctly identify matches	0.8	1.4	3.5	0.2	1.9	1.4	-0.7
Smoking status: Previous	0.8	1.2	2.2	-0.5	1.5	1.3	-0.9
Loneliness, isolation	0.8	1.1	2.3	-0.0	1.1	-1.0	1.5
Illnesses of father: High blood pressure	0.8	1.0	1.7	-0.9	-0.9	0.9	1.3
Irritability	0.8	1.4	3.3	0.4	0.8	-1.2	1.8
Alzheimer’s Disease (in father)	0.7	0.7	2.8	-1.7	0.1	0.0	0.4
Mean Putamen Volume	0.7	0.8	2.6	-0.0	0.4	0.6	-1.6
Schizophrenia (2014)	0.7	1.5	5.8	2.4	0.5	0.3	0.1
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.6	-0.4	-1.6	0.2	-0.6
Type 2 Diabetes (T2D) (2018)	0.7	1.2	2.6	0.9	1.6	1.1	-0.5
Hearing difficulty/problems: Yes	0.7	1.1	3.2	1.8	0.1	0.7	0.7
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.6	-0.6	-1.0	-1.3	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.9	1.2	1.7	0.2	-0.3
Alcohol intake versus 10 years previously	0.7	1.1	2.5	0.5	1.1	1.6	0.6
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	5.0	-0.9	-1.5	-2.2	-1.2
Happiness	0.7	0.8	2.4	0.5	0.3	1.6	0.6
Lung cancer (father)	0.7	0.8	1.7	-1.3	-0.4	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	3.7	-1.2	-1.8	-1.9	-0.5
Hair/balding pattern: Pattern 4	0.7	1.7	4.6	0.3	2.2	1.4	0.1
Exposure to tobacco smoke outside home	0.7	1.0	2.9	0.7	-0.7	-0.4	-1.7
Neck or shoulder pain in last month	0.7	1.0	1.9	0.1	-1.4	1.2	-0.8
Illnesses of father: Heart disease	0.7	1.0	2.0	1.1	-0.6	-1.4	0.5
Illnesses of father: None of the above (group 1)	0.7	0.8	2.7	-0.0	0.7	0.3	-1.6
Ever taken oral contraceptive pill	0.7	0.8	1.4	1.2	-0.6	0.9	-0.8
Hearing aid user	0.7	0.8	1.8	-0.6	-1.3	-0.4	1.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.3	0.7	0.5	-0.2	-1.5
Unable to work because of sickness or disability	0.7	0.9	2.3	0.4	1.5	0.9	-0.7
Depression (Nagel 2018)	0.6	0.9	1.6	0.2	1.3	1.1	-0.8
Age at First Birth	0.6	0.9	1.4	-0.6	-1.2	-0.9	-1.0
Coronary Artery Disease (CAD)	0.6	0.8	1.7	-1.3	0.4	1.0	-0.4
LDL Cholesterol	0.6	0.9	1.6	0.6	-0.5	-1.3	1.2
Impedance of leg (right)	0.6	2.9	6.4	2.0	2.5	0.9	-0.4
Taking other prescription medications	0.6	0.9	2.4	-1.5	0.4	0.6	-0.8
Qualifications: CSEs or equivalent	0.6	0.9	2.7	0.1	-0.8	-1.6	-0.4
Medication: Atenolol	0.6	0.7	1.8	1.3	0.4	0.3	0.9
Number of live births	0.6	0.9	1.3	1.0	0.9	-0.7	1.1
Breastfed as a baby	0.6	0.8	1.2	1.1	0.7	1.1	0.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.5	0.2	-1.2	-1.2	0.3
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.9	0.4	0.9	0.1	2.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.4	-1.2	-0.1	-1.1	-0.2
Supplements: Vitamin C	0.6	0.7	1.3	-1.1	-0.5	-0.5	-1.0
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.1	0.7	0.3	0.4	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.2	1.1	1.1	-0.3	0.4
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.7	-0.8	-0.4	-1.7	0.2
Osteoporosis (self-reported)	0.6	0.7	1.4	0.8	0.3	0.8	1.2
Average weekly beer plus cider intake	0.6	0.9	1.6	0.3	1.0	1.3	1.0
Fractured/broken bones in last 5 years	0.6	0.7	2.0	0.2	0.8	0.3	-1.4
Vascular/heart problems diagnosed by doctor	0.6	1.5	2.7	-1.2	-1.7	-0.6	-1.3
Pack years of smoking	0.6	0.8	1.9	-0.7	-1.4	0.7	-0.6
Bipolar Disorder or Schizophrenia	0.5	1.1	2.8	1.7	1.2	0.3	0.4
Reaction Time	0.5	1.0	1.9	0.4	1.2	0.7	-1.4
Pack years adult smoking proportion	0.5	0.7	1.6	-0.6	-1.3	0.7	-0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.8	0.5	0.3	-0.1	1.3
Supplements: Glucosamine	0.5	0.6	1.8	-0.6	0.2	-0.5	-1.4
Number of incorrect matches in round	0.5	0.9	1.9	0.9	1.4	0.7	0.6
Nervous feelings	0.5	0.9	1.8	-1.3	-0.6	0.2	-1.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	0.5	-1.2	-0.9	0.0
Neuroticism score	0.5	1.0	3.3	0.7	1.8	-0.4	0.5
Length of working week for main job	0.5	0.5	1.1	0.3	1.0	-0.9	-0.3
Exposure to tobacco smoke at home	0.5	0.5	1.8	1.3	-0.3	-0.5	0.1
Tense / ‘highly strung’	0.5	0.8	2.2	-0.1	0.4	-1.5	0.8
Birth weight	0.5	1.0	2.9	-0.7	-0.7	0.1	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.6	0.6	0.9	-0.3	-1.3
Ever had bowel cancer screening	0.5	0.6	1.3	0.8	0.2	-1.2	0.5
Friendships satisfaction	0.5	0.6	1.4	-0.6	-1.2	0.2	-0.9
Commuting to job workplace: Walk	0.5	0.5	0.9	0.8	-0.1	-0.9	-0.8
Medication for cholesterol	0.5	0.7	1.8	0.4	0.8	1.3	0.5
Number of self-reported non-cancer illnesses	0.5	0.9	2.2	1.5	1.2	-0.3	-0.1
Financial situation satisfaction	0.5	0.6	0.8	0.9	0.6	-0.7	-0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.0	0.7	-0.5	0.9	-1.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	0.9	-0.9	0.2	0.8	-1.0
Ever depressed for a whole week	0.5	0.6	1.4	0.3	-0.8	-0.6	1.2
Bipolar Disorder (2018)	0.4	0.6	1.5	-0.1	0.9	1.2	-0.2
Bipolar Disorder (2011)	0.4	0.4	0.7	0.1	0.8	0.4	0.7
Crohns Disease (2012)	0.4	0.6	1.6	0.7	-0.4	-0.5	-1.3
Waist Hip Ratio (WHR)	0.4	1.8	5.4	2.3	0.6	-0.2	1.1
Smoking Status	0.4	0.9	1.4	1.0	1.2	1.0	-0.4
Allergy or Eczema	0.4	1.0	2.5	-1.1	-0.4	-0.3	-1.6
Chronotype (morning person)	0.4	0.9	2.7	0.7	-0.2	-1.6	-0.7
Relative age of first facial hair	0.4	0.8	3.1	-0.1	0.3	1.8	-0.2
Vitamin and mineral supplements	0.4	0.6	2.1	1.4	0.2	0.3	-0.3
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.9	-1.4	-0.5	-0.1	-1.2
High blood pressure (mother)	0.4	0.6	1.5	0.5	0.7	0.4	1.2
Impedance of leg (left)	0.4	2.0	4.5	1.7	2.1	0.4	-0.7
Past tobacco smoking	0.4	0.7	1.8	0.1	-1.4	-0.9	0.3
Medication: Ramipril	0.4	0.5	0.8	0.8	0.3	-0.5	-0.9
Medication: Simvastatin	0.4	0.7	2.0	0.3	0.4	-1.4	-0.6
Father’s age at death	0.4	0.5	1.6	0.1	-1.3	-0.4	-0.6
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.3	-1.0	-1.5	-0.1	-0.9
Medication: Cholesterol lowering	0.4	0.6	1.3	1.2	0.8	0.2	-0.7
Gout (self-reported)	0.4	0.6	2.2	-0.0	0.2	0.1	1.5
Worry too long after embarrassment	0.4	0.7	1.7	1.0	0.3	-0.0	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.6	-0.6	-1.3	0.2	-0.3
Medication: Allopurinol	0.4	0.6	1.5	0.9	0.2	-0.1	1.2
Suffer from ‘nerves’	0.4	0.6	1.1	-0.0	0.4	1.1	-1.0
Hypertension (Self-reported)	0.4	1.1	2.4	1.1	1.5	0.1	1.0
Mood swings	0.4	0.8	1.7	-0.2	0.6	-1.3	-1.0
Qualifications: nursing, teaching	0.4	0.7	1.2	-0.3	-1.1	-0.7	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.1	-0.6	0.1	1.1	-0.8
Mineral and other dietary supplements	0.4	0.6	0.9	1.0	-0.6	-0.4	1.0
Commuting to job workplace: Public transport	0.4	0.4	1.4	0.2	-0.5	-0.2	-1.2
Medication: Blood pressure	0.4	0.7	2.3	0.5	1.5	0.3	-0.5
Diastolic blood pressure, automated reading	0.4	1.2	3.1	-1.7	-1.1	0.4	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.3	0.1	0.8	1.1	0.3
Heart disease (siblings)	0.4	0.4	1.1	-0.8	-1.0	0.1	0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	1.3	1.1	0.2	0.2	-0.5
Worry (Nagel 2018)	0.3	0.6	1.4	0.4	1.2	0.7	-0.4
Breast Cancer	0.3	0.6	1.2	-0.2	0.8	0.9	1.1
Neuroticism (2016)	0.3	0.5	0.8	-0.3	0.3	-0.9	-0.9
Blood Eosinophil Count	0.3	2.6	7.4	1.1	0.6	1.2	2.7
Number of treatments/medications taken	0.3	0.5	1.3	0.1	0.4	-1.1	-0.7
Sensitivity / hurt feelings	0.3	0.5	1.4	-1.2	-0.4	-0.4	0.5
Age when periods started (menarche)	0.3	0.8	2.0	1.4	0.6	0.6	-0.5
High blood pressure	0.3	0.7	1.8	0.9	1.4	0.1	0.6
Hearing difficulty/problems with background noise	0.3	0.5	1.4	0.6	0.6	1.2	0.2
Hip circumference	0.3	1.2	3.7	-1.9	-0.9	0.3	0.1
Depression (self-reported)	0.3	0.3	0.9	0.1	0.5	-1.0	-0.4
Medication: Lansoprazole	0.3	0.4	0.9	0.1	0.9	0.0	0.8
Blood clot in the leg (DVT)	0.3	0.4	1.3	0.1	0.5	1.1	0.2
Headache pain in last month	0.3	0.6	2.0	-0.2	-0.5	-0.1	1.4
Medication: Seretide 50 evohaler	0.3	0.3	0.4	0.6	-0.3	0.6	0.7
Leg pain on walking	0.3	0.3	0.6	0.8	0.6	0.0	0.6
Knee pain experienced in last month	0.3	0.4	1.2	0.3	-0.4	-1.1	-0.4
Diabetes diagnosed by doctor	0.3	0.4	0.8	0.2	0.8	0.9	0.5
Osteoarthritis (self-reported)	0.3	0.4	1.3	-0.0	-0.5	0.3	-1.1
Number of operations (self-reported)	0.3	0.5	1.5	-0.3	0.6	1.2	0.3
Basal cell carcinoma (self-reported)	0.3	0.3	1.0	-1.0	-0.3	0.4	0.1
Alzheimer’s Disease (in mother)	0.2	0.3	0.6	-0.1	-0.5	-0.8	0.5
Alzheimer’s Disease (including proxy)	0.2	0.2	0.4	-0.6	-0.5	-0.4	0.4
Crohns Disease (2017)	0.2	0.4	1.5	1.2	0.1	-0.4	-0.2
Irritable Bowel Disease (IBD)	0.2	0.4	0.8	0.9	-0.3	-0.8	0.1
Ulcerative Colitis (UC)	0.2	0.4	0.8	0.2	-0.9	-0.8	0.1
Blood Platelet Count	0.2	2.4	6.0	-0.7	-2.4	-1.6	-0.7
Cardiovascular Disease	0.2	0.5	1.3	0.6	1.1	0.4	0.5
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.5	0.2	0.7	0.5	-0.3
Ever had hysterectomy (womb removed)	0.2	0.3	1.0	-0.2	0.0	-0.1	1.0
Leg fat-free mass (left)	0.2	1.0	1.8	-1.3	-0.7	-0.1	1.3
Trunk fat percentage	0.2	0.9	1.3	-1.0	-1.0	-0.5	1.1
Hand grip strength (right)	0.2	0.6	2.0	-0.2	0.6	-0.4	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	0.7	0.2	0.7	-0.3
Relative age voice broke	0.2	0.3	0.8	-0.4	-0.9	0.0	0.1
Body mass index (BMI)	0.2	0.7	1.0	-1.0	-0.8	-0.4	1.0
Leg predicted mass (left)	0.2	1.1	1.9	-1.3	-0.8	-0.1	1.4
Trunk fat mass	0.2	0.8	1.8	-0.9	-0.6	-0.5	1.4
Waist circumference	0.2	0.6	1.5	-0.7	-0.4	-0.2	1.2
Forced vital capacity (FVC)	0.2	0.8	2.4	-0.7	-0.5	-0.1	-1.5
Impedance of arm (right)	0.2	0.9	1.7	-0.5	0.8	1.1	-1.3
Arm fat percentage (right)	0.2	0.6	1.3	-1.0	-1.1	-0.2	0.4
Time employed in main current job	0.2	0.3	0.6	-0.2	0.4	0.8	-0.5
Arm fat mass (right)	0.2	0.7	0.9	-0.9	-1.0	-0.3	0.9
Forced vital capacity (FVC), Best measure	0.2	0.7	1.8	-1.3	-1.0	0.3	-0.3
Body fat percentage	0.2	0.7	1.4	-0.9	-0.7	-0.2	1.2
Comparative body size at age 10	0.2	0.7	1.5	0.7	-0.3	-1.2	-0.7
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	0.7	-0.7	-0.3	-0.1
Whole body fat mass	0.2	0.8	2.1	-0.9	-0.5	-0.1	1.4
Arm predicted mass (right)	0.2	0.8	2.2	-0.6	-0.4	-0.7	1.5
Comparative height size at age 10	0.2	0.9	1.8	-0.1	1.4	1.1	0.7
Illnesses of siblings: Diabetes	0.2	0.3	0.7	-0.5	-0.8	-0.2	0.4
Leg fat-free mass (right)	0.2	1.2	2.0	-1.4	-1.1	-0.4	1.1
Arm fat percentage (left)	0.2	1.0	1.8	-1.0	-1.3	-0.7	0.7
Eye problems/disorders: Cataract	0.2	0.2	0.5	-0.3	0.7	0.5	-0.4
Breast cancer (self-reported)	0.2	0.3	0.7	0.2	0.8	0.6	0.3
Leg predicted mass (right)	0.2	1.2	2.2	-1.5	-1.1	-0.4	1.2
Arm fat mass (left)	0.2	0.7	1.0	-0.9	-1.0	-0.5	1.0
High cholesterol (Self-reported)	0.2	0.4	0.5	-0.7	0.7	0.5	-0.6
Ever smoked	0.2	0.4	1.4	-0.2	0.3	0.3	-1.2
Cholesterol lowering medication	0.2	0.3	0.9	-1.0	-0.0	0.5	0.3
Alcohol drinker status: Previous	0.2	0.2	0.5	0.5	-0.4	0.0	0.7
Ovarian Cancer	0.1	0.1	0.3	-0.2	-0.5	-0.2	-0.1
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.5	-0.3	-0.4	-0.0
HbA1C	0.1	0.1	0.3	-0.6	-0.2	-0.3	0.3
Ulcerative Colitis	0.1	0.2	0.4	0.3	-0.6	-0.5	-0.2
Blood Red Count	0.1	1.2	2.7	-1.6	-0.8	0.7	-1.0
Blood White Count	0.1	1.1	3.9	-0.1	-0.4	-2.0	0.6
Heel T-Score	0.1	0.8	2.3	-0.8	-0.4	0.4	-1.5
BMI	0.1	0.6	1.2	-0.5	-1.0	-0.3	1.1
Systolic Blood Pressure	0.1	0.3	1.1	1.1	0.3	0.2	0.4
Hand grip strength (left)	0.1	0.4	0.7	0.1	0.6	-0.6	0.8
Systolic blood pressure, automated reading	0.1	0.2	0.2	0.4	-0.5	-0.4	-0.3
Current tobacco smoking	0.1	0.2	0.5	0.2	0.3	0.5	0.7
Maternal smoking around birth	0.1	0.1	0.5	-0.1	0.1	0.7	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	-0.3	0.2	0.9	-0.4
Stomach or abdominal pain in last month	0.1	0.2	0.5	0.7	-0.2	-0.1	-0.4
Sitting height	0.1	0.9	2.2	-0.2	1.5	1.1	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	-0.3	0.2	0.3	-0.8
Diabetes (self-reported)	0.1	0.2	0.4	0.3	0.6	0.5	0.2
Weight	0.1	0.6	1.2	-1.1	-0.5	-0.3	0.8
Trunk fat-free mass	0.1	0.3	1.0	-0.3	0.4	0.1	1.0
Worrier / anxious feelings	0.1	0.2	0.7	0.5	0.8	0.1	0.0
Prospective memory result	0.1	0.1	0.2	-0.1	0.5	-0.4	0.1
Trunk predicted mass	0.1	0.3	1.1	-0.3	0.4	0.0	1.0
Arm fat-free mass (right)	0.1	0.6	2.0	-0.4	-0.3	-0.5	1.4
Leg fat mass (right)	0.1	0.6	1.8	-0.7	0.3	-0.0	1.3
Alcohol intake frequency.	0.1	0.3	1.2	1.1	0.3	0.2	0.2
Family relationship satisfaction	0.1	0.2	0.3	-0.1	0.4	0.4	-0.6
Whole body fat-free mass	0.1	0.5	1.5	-0.7	-0.2	-0.1	1.2
Smoking status: Current	0.1	0.2	0.4	0.2	0.2	0.4	0.6
Whole body water mass	0.1	0.5	1.3	-0.8	-0.2	-0.1	1.2
Basal metabolic rate	0.1	0.4	1.2	-0.7	-0.2	-0.2	1.1
Arm fat-free mass (left)	0.1	0.4	1.4	-0.4	0.0	-0.1	1.2
Risk taking	0.1	0.2	0.5	-0.1	0.7	0.3	0.4
Impedance of whole body	0.1	0.5	1.1	0.7	1.1	0.3	-0.5
Leg fat mass (left)	0.1	0.5	1.4	-0.8	0.1	-0.1	1.2
Arm predicted mass (left)	0.1	0.4	1.5	-0.3	-0.2	-0.4	1.2
Height	0.0	0.3	0.9	-0.2	0.2	-0.3	1.0
Hair Pigment	0.0	1.2	1.6	0.5	-1.3	-1.1	-1.3
Tanning	0.0	0.3	0.8	0.4	0.3	0.4	-0.9
Impedance of arm (left)	0.0	0.1	0.2	-0.2	0.3	0.2	-0.4
Standing height	0.0	0.2	0.4	-0.4	0.6	0.3	0.0
Leg fat percentage (right)	0.0	0.1	0.4	0.1	0.3	-0.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	0.3	-0.2	-0.3	-0.3
Long-standing illness, disability or infirmity	0.0	0.1	0.1	0.4	0.3	0.1	0.1
Leg fat percentage (left)	0.0	0.1	0.2	-0.1	0.0	-0.3	0.4
Pain experienced in last month	0.0	0.1	0.1	-0.3	-0.1	-0.2	0.4

Hub : Genes

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Trait associations