Best TWAS P=9.49e-09 · Best GWAS P=1.41e-07 conditioned to 0.146
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | PSRC1 | 0.18 | 0.14 | lasso | 3 | 0.14 | 2.4e-09 | -5.3 | -5.2 | 2.1e-07 | 0.97 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Liver | CELSR2 | 0.39 | 0.36 | lasso | 1 | 0.35 | 1.0e-10 | -5.3 | -5.3 | 1.4e-07 | 1.00 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Muscle Skeletal | CELSR2 | 0.41 | 0.31 | lasso | 4 | 0.30 | 2.4e-30 | -5.3 | -5.3 | 1.3e-07 | 1.00 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | CELSR2 | 0.18 | 0.05 | lasso | 6 | 0.06 | 8.1e-06 | -4.3 | -5.7 | 9.5e-09 | 0.75 | 0.01 | 0.98 | TRUE |
| 5 | GTEx | Whole Blood | PSRC1 | 0.14 | 0.04 | lasso | 3 | 0.03 | 6.9e-04 | -5.2 | -5.2 | 2.5e-07 | 0.99 | 0.00 | 0.99 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PSRC1 | 0.33 | 0.21 | bslmm | 430 | 0.26 | 1.2e-32 | -5.3 | -5.1 | 3.0e-07 | 0.82 | 0.00 | 1.00 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | CELSR2 | 0.25 | 0.21 | lasso | 6 | 0.23 | 4.9e-29 | -5.3 | -5.2 | 1.8e-07 | 0.96 | 0.00 | 1.00 | FALSE |