[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr1:110,716,511-113,310,418

Best TWAS P=2.14e-28 · Best GWAS P=3.05e-30 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
59	The Cancer Genome Atlas	Thyroid Carcinoma	DENND2D	0.13	0.06	lasso	3	0.06	3.9e-06	11.4	-11.1	2.1e-28	0.36	0.00	1.00	TRUE
17	GTEx	Cells Transformed fibroblasts	CEPT1	0.38	0.27	lasso	6	0.31	7.7e-24	11.4	8.1	3.9e-16	-0.18	0.00	1.00	TRUE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	DENND2D	0.06	0.02	blup	77	0.02	3.2e-03	-10.0	-7.1	9.8e-13	0.71	0.01	0.56	TRUE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CEPT1	0.03	0.03	blup	57	0.02	2.2e-03	1.1	-6.6	3.4e-11	0.57	0.08	0.35	TRUE
50	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	WNT2B	0.10	0.04	blup	46	0.03	2.7e-03	-5.1	-6.5	9.1e-11	0.05	0.01	0.99	TRUE
45	GTEx	Whole Blood	DRAM2	0.15	0.11	lasso	10	0.12	6.7e-11	11.4	10.5	1.4e-25	-0.37	0.00	1.00	FALSE
35	GTEx	Pituitary	DENND2D	0.34	0.10	lasso	6	0.15	1.1e-04	-8.0	-10.4	2.3e-25	0.64	0.04	0.83	FALSE
43	GTEx	Uterus	DRAM2	0.45	0.20	lasso	7	0.14	1.0e-03	8.7	10.0	1.0e-23	-0.34	0.01	0.93	FALSE
7	GTEx	Artery Tibial	RAP1A	0.14	0.00	lasso	3	0.00	3.8e-01	-11.4	9.8	8.9e-23	-0.85	0.01	0.91	FALSE
18	GTEx	Cells Transformed fibroblasts	DRAM2	0.43	0.36	lasso	3	0.45	1.1e-36	11.4	9.8	1.2e-22	-0.33	0.00	1.00	FALSE
24	GTEx	Esophagus Mucosa	DRAM2	0.35	0.34	lasso	5	0.36	1.0e-24	9.4	9.8	1.5e-22	-0.39	1.00	0.00	FALSE
25	GTEx	Esophagus Mucosa	DENND2D	0.21	0.13	lasso	5	0.14	2.3e-09	11.4	-9.8	1.6e-22	0.29	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	DRAM2	0.17	0.15	enet	9	0.14	7.0e-14	8.7	9.7	2.5e-22	-0.35	1.00	0.00	FALSE
19	GTEx	Cells Transformed fibroblasts	DENND2D	0.31	0.16	lasso	6	0.19	4.9e-14	11.4	9.6	7.3e-22	-0.31	0.00	1.00	FALSE
57	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	DRAM2	0.15	0.07	lasso	3	0.08	6.3e-04	8.7	9.4	5.9e-21	-0.40	0.08	0.55	FALSE
3	GTEx	Adipose Visceral Omentum	DRAM2	0.55	0.45	lasso	8	0.44	8.4e-25	8.7	9.2	5.6e-20	-0.33	0.98	0.02	FALSE
2	GTEx	Adipose Subcutaneous	DRAM2	0.47	0.45	lasso	7	0.48	2.2e-44	8.7	9.1	7.2e-20	-0.30	0.92	0.08	FALSE
39	GTEx	Skin Sun Exposed Lower leg	DRAM2	0.42	0.41	lasso	5	0.41	1.2e-36	8.3	9.0	1.7e-19	-0.30	0.96	0.04	FALSE
21	GTEx	Colon Sigmoid	DRAM2	0.56	0.50	lasso	5	0.50	3.0e-20	8.7	8.9	3.7e-19	-0.31	0.82	0.18	FALSE
38	GTEx	Skin Not Sun Exposed Suprapubic	DRAM2	0.47	0.38	enet	9	0.34	1.9e-19	8.3	8.8	1.2e-18	-0.29	0.88	0.12	FALSE
14	GTEx	Brain Putamen basal ganglia	DRAM2	0.42	0.31	lasso	6	0.35	4.3e-09	8.7	8.8	1.7e-18	-0.32	0.05	0.93	FALSE
26	GTEx	Esophagus Muscularis	DRAM2	0.52	0.45	lasso	8	0.45	7.1e-30	8.3	8.7	3.5e-18	-0.39	1.00	0.00	FALSE
30	GTEx	Lung	DRAM2	0.39	0.42	lasso	8	0.41	9.7e-34	8.3	8.6	8.7e-18	-0.33	1.00	0.00	FALSE
4	GTEx	Adrenal Gland	DRAM2	0.59	0.40	enet	25	0.40	1.3e-15	8.7	8.6	1.1e-17	-0.28	0.19	0.81	FALSE
46	METSIM	Adipose	CEPT1	0.18	0.16	lasso	4	0.17	1.2e-24	11.4	8.5	1.3e-17	-0.12	0.00	1.00	FALSE
8	GTEx	Artery Tibial	DRAM2	0.41	0.40	lasso	4	0.40	1.6e-33	8.3	8.5	1.9e-17	-0.32	1.00	0.00	FALSE
6	GTEx	Artery Coronary	DRAM2	0.44	0.24	enet	26	0.27	1.1e-09	8.7	8.5	2.0e-17	-0.33	0.34	0.66	FALSE
5	GTEx	Artery Aorta	DRAM2	0.63	0.49	lasso	7	0.49	1.1e-30	8.3	8.5	2.6e-17	-0.32	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DRAM2	0.42	0.50	lasso	3	0.50	3.1e-70	8.3	8.4	3.5e-17	-0.32	1.00	0.00	FALSE
31	GTEx	Muscle Skeletal	DRAM2	0.44	0.39	lasso	4	0.39	2.8e-40	8.3	8.4	5.3e-17	-0.32	1.00	0.00	FALSE
42	GTEx	Thyroid	DRAM2	0.39	0.46	lasso	3	0.45	3.2e-38	8.3	8.4	6.3e-17	-0.32	1.00	0.00	FALSE
32	GTEx	Nerve Tibial	DRAM2	0.53	0.56	lasso	4	0.55	2.1e-46	8.3	8.3	6.6e-17	-0.32	1.00	0.00	FALSE
28	GTEx	Heart Left Ventricle	DRAM2	0.32	0.25	lasso	7	0.21	2.1e-11	8.3	8.3	7.5e-17	-0.32	0.56	0.44	FALSE
55	The Cancer Genome Atlas	Lung Adenocarcinoma	DENND2D	0.06	0.01	enet	15	0.01	4.7e-02	-7.3	-8.3	7.7e-17	0.58	0.03	0.32	FALSE
15	GTEx	Breast Mammary Tissue	DRAM2	0.39	0.31	lasso	2	0.32	3.9e-17	8.3	8.3	9.5e-17	-0.32	1.00	0.00	FALSE
36	GTEx	Prostate	DRAM2	0.43	0.26	lasso	6	0.15	1.3e-04	8.3	8.3	1.0e-16	-0.31	0.07	0.87	FALSE
33	GTEx	Pancreas	DRAM2	0.33	0.31	lasso	2	0.27	6.0e-12	8.3	8.3	1.3e-16	-0.32	0.99	0.01	FALSE
40	GTEx	Stomach	DRAM2	0.34	0.33	lasso	2	0.32	9.7e-16	8.3	8.3	1.3e-16	-0.32	0.96	0.04	FALSE
12	GTEx	Brain Cortex	DRAM2	0.35	0.28	lasso	5	0.30	3.9e-09	8.3	8.2	1.5e-16	-0.29	0.30	0.66	FALSE
13	GTEx	Brain Nucleus accumbens basal ganglia	DRAM2	0.43	0.47	lasso	2	0.45	1.7e-13	8.3	8.2	1.7e-16	-0.32	0.88	0.11	FALSE
27	GTEx	Heart Atrial Appendage	DRAM2	0.44	0.33	lasso	3	0.30	9.1e-14	8.3	8.2	3.1e-16	-0.34	0.63	0.37	FALSE
44	GTEx	Vagina	DRAM2	0.43	0.45	lasso	2	0.46	7.4e-12	8.3	8.1	5.4e-16	-0.31	0.31	0.64	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	DRAM2	0.35	0.25	lasso	7	0.28	1.2e-10	8.7	8.1	6.0e-16	-0.33	0.56	0.44	FALSE
10	GTEx	Brain Cerebellar Hemisphere	DRAM2	0.53	0.47	lasso	3	0.46	1.5e-13	8.3	8.1	6.6e-16	-0.33	0.17	0.82	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	DRAM2	0.30	0.34	lasso	7	0.35	4.1e-47	8.3	8.0	1.1e-15	-0.26	1.00	0.00	FALSE
34	GTEx	Pituitary	DRAM2	0.58	0.31	lasso	12	0.28	8.8e-08	8.3	7.9	2.5e-15	-0.30	0.11	0.86	FALSE
9	GTEx	Brain Caudate basal ganglia	DRAM2	0.30	0.19	lasso	4	0.15	3.4e-05	8.3	7.9	3.0e-15	-0.32	0.14	0.72	FALSE
11	GTEx	Brain Cerebellum	DRAM2	0.69	0.52	lasso	11	0.49	1.8e-16	8.3	7.8	4.4e-15	-0.31	0.57	0.43	FALSE
16	GTEx	Breast Mammary Tissue (Female)	DRAM2	0.30	0.18	lasso	4	0.22	3.9e-07	8.3	7.8	4.4e-15	-0.22	0.32	0.27	FALSE
29	GTEx	Liver	DRAM2	0.55	0.32	lasso	7	0.32	1.1e-09	8.7	7.7	1.2e-14	-0.24	0.22	0.78	FALSE
22	GTEx	Colon Transverse	DRAM2	0.46	0.41	lasso	5	0.41	5.6e-21	8.3	7.5	5.4e-14	-0.27	0.95	0.05	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	CD53	0.16	0.00	enet	31	0.02	3.6e-02	4.1	7.3	3.7e-13	-0.41	0.10	0.06	FALSE
48	METSIM	Adipose	DRAM2	0.42	0.36	lasso	6	0.40	1.0e-64	8.7	7.2	4.2e-13	-0.14	0.57	0.43	FALSE
20	GTEx	Cells Transformed fibroblasts	RP5-1180E21.5	0.24	0.08	lasso	8	0.15	3.3e-11	11.4	7.0	2.6e-12	-0.18	0.00	1.00	FALSE
51	The Cancer Genome Atlas	Colon Adenocarcinoma	DENND2D	0.13	0.00	blup	77	0.05	6.1e-04	-1.7	-6.2	4.9e-10	0.42	0.01	0.22	FALSE
41	GTEx	Testis	DRAM2	0.20	0.13	lasso	5	0.16	1.5e-07	8.3	5.8	6.5e-09	-0.05	0.01	0.99	FALSE
47	METSIM	Adipose	CHI3L2	0.04	0.01	bslmm	589	0.01	3.4e-03	9.4	5.8	7.1e-09	-0.28	0.05	0.61	FALSE
56	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DRAM2	0.16	0.02	blup	39	0.08	4.4e-04	5.6	5.8	9.2e-09	-0.10	0.04	0.07	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	DRAM2	0.14	0.13	enet	7	0.15	2.9e-16	8.7	5.7	1.3e-08	-0.16	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CTTNBP2NL	0.04	0.00	blup	53	0.02	2.1e-03	-2.0	-5.3	1.4e-07	0.03	0.01	0.68	FALSE