Best TWAS P=8.95e-08 · Best GWAS P=1.1e-07 conditioned to 0.0458
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | PTK2 | 0.25 | 0.22 | lasso | 3 | 0.31 | 6.6e-10 | 3.5 | -5.3 | 9.0e-08 | -0.55 | 0.14 | 0.57 | TRUE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | PTK2 | 0.05 | 0.07 | lasso | 4 | 0.07 | 5.4e-09 | 5.2 | -5.1 | 2.8e-07 | -0.94 | 0.07 | 0.92 | FALSE |
| 3 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DENND3 | 0.06 | 0.03 | blup | 98 | 0.04 | 4.0e-05 | 3.2 | -5.3 | 9.1e-08 | -0.13 | 0.01 | 0.13 | TRUE |