TWAS hub - DENND3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0940	0.0290	1.6e-04	0.078	0.029	0.066	0.052	0.074	1.0e-09	1.5e-04	2.0e-08	5.8e-07	2.6e-09
2	GTEx	Cells Transformed fibroblasts	0.2630	0.0550	1.2e-07	0.146	NA	0.177	NA	0.046	4.5e-11	NA	3.0e-13	NA	2.4e-04
3	GTEx	Colon Sigmoid	0.2180	0.0730	3.8e-03	-0.008	NA	0.013	NA	0.000	8.0e-01	NA	1.1e-01	NA	3.3e-01
4	GTEx	Esophagus Muscularis	0.1930	0.0640	2.8e-03	-0.003	NA	-0.003	NA	0.000	5.5e-01	NA	6.2e-01	NA	3.4e-01
5	GTEx	Skin Sun Exposed Lower leg	0.0890	0.0330	1.4e-03	0.113	NA	0.084	NA	0.056	1.4e-09	NA	1.8e-07	NA	2.1e-05
6	NTR	Blood	0.0272	0.0108	1.1e-03	0.011	0.007	0.006	0.008	0.012	1.2e-04	1.9e-03	2.7e-03	7.2e-04	7.9e-05
7	ROSMAP	Brain Pre-frontal Cortex	0.0981	0.0287	6.2e-05	0.051	0.051	0.052	0.052	0.052	3.3e-07	3.9e-07	2.8e-07	2.5e-07	3.1e-07
8	YFS	Blood	0.2197	0.0268	0.0e+00	0.248	0.244	0.260	0.251	0.260	2.1e-80	7.5e-79	1.2e-84	2.4e-81	6.3e-85
9	TCGA	Breast Invasive Carcinoma	0.0541	0.0191	5.1e-07	0.006	0.029	0.040	NA	0.033	1.5e-02	9.2e-07	1.3e-08	NA	1.6e-07
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0932	0.0324	1.1e-06	0.022	0.063	0.076	NA	0.084	1.3e-03	1.1e-07	6.9e-09	NA	1.0e-09
11	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1180	0.0510	7.4e-04	0.097	0.064	0.070	NA	0.066	3.5e-06	1.5e-04	7.8e-05	NA	1.2e-04
12	TCGA	Brain Lower Grade Glioma	0.0611	0.0255	7.9e-05	0.027	0.037	0.027	NA	0.031	4.7e-04	4.0e-05	4.6e-04	NA	1.6e-04
13	TCGA	Liver Hepatocellular Carcinoma	0.1610	0.0670	1.8e-03	0.090	0.088	0.087	NA	0.101	5.1e-05	6.4e-05	6.7e-05	NA	1.7e-05
14	TCGA	Lung Adenocarcinoma	0.0377	0.0170	9.7e-04	0.014	0.015	0.029	NA	0.025	8.1e-03	6.1e-03	2.0e-04	NA	5.0e-04
15	TCGA	Prostate Adenocarcinoma	0.0707	0.0257	6.5e-06	0.013	0.052	0.045	NA	0.022	1.5e-02	3.3e-06	1.5e-05	NA	2.1e-03
16	TCGA	Soft Tissue Sarcoma	0.1660	0.0510	7.2e-06	0.070	0.101	0.106	NA	0.111	5.4e-05	1.3e-06	7.4e-07	NA	4.3e-07
17	TCGA	Thyroid Carcinoma	0.1240	0.0390	4.8e-08	0.046	0.077	0.106	NA	0.119	2.8e-05	6.0e-08	1.6e-10	NA	1.2e-11
18	TCGA	Uterine Corpus Endometrial Carcinoma	0.2970	0.0990	6.2e-04	0.025	0.065	0.063	NA	0.032	6.6e-02	6.8e-03	7.8e-03	NA	4.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Number of operations (self-reported)	6.5	9.7	25.6	2.1	3.3	0.5	3.0	3.9	-1.7	-1.3	1.4	4.1	3.4	4.1	2.9	1.7	3.0	2.3	4.3	3.7	5.1
Hearing aid user	4.6	5.2	12.5	-2.5	-3.2	0.1	-2.4	-1.8	-2.9	-1.7	-2.7	-2.4	-2.2	-2.4	-2.2	-1.0	-2.3	-3.5	-1.5	-2.2	-1.6
Leg pain on walking	4.0	5.0	12.5	0.6	1.5	3.5	2.8	3.1	-2.5	-1.5	0.4	2.3	2.9	2.8	2.1	-0.2	2.2	0.2	1.9	1.7	3.3
Alzheimer’s Disease (in father)	3.9	4.2	7.9	-2.3	-2.5	-1.5	-2.6	-2.4	-0.5	-0.4	-2.0	-2.1	-2.2	-1.7	-1.5	0.2	-1.6	-2.4	-2.7	-2.8	-2.5
Had other major operations	3.6	4.4	10.6	0.8	2.2	1.9	2.6	3.2	-1.1	0.1	1.1	2.3	2.4	2.3	1.4	-0.6	1.6	2.0	2.6	2.9	3.3
Average weekly spirits intake	3.3	4.1	12.0	-2.6	-0.2	-2.4	-1.1	1.4	-0.7	-1.0	-3.1	-0.7	-3.5	-1.3	-2.6	-1.2	-2.5	-2.1	-2.3	-2.3	-1.6
Osteoarthritis (self-reported)	3.3	4.3	14.7	-3.4	-2.0	-1.2	-1.2	-0.6	-2.0	-1.6	-3.2	-2.2	-1.3	-1.1	-2.1	-3.8	-2.5	-2.0	-1.3	-1.5	-1.5
Blood White Count	3.0	22.0	63.7	6.7	3.8	3.6	2.3	-0.2	7.7	8.0	7.3	3.5	1.2	1.2	3.9	5.7	2.9	6.2	3.6	4.5	0.6
Hypothyroidism (self reported)	3.0	6.9	21.3	3.3	3.0	1.3	2.1	1.1	3.0	0.5	3.3	1.3	2.6	2.0	3.3	-0.4	2.1	3.3	3.5	4.6	2.0
Medication: Levothyroxine sodium	3.0	5.0	18.1	2.5	1.9	1.3	0.9	0.8	1.4	-1.0	2.1	1.9	2.4	2.0	2.5	1.1	2.4	1.4	3.7	4.3	2.9
Ever depressed for a whole week	3.0	3.7	8.4	1.1	2.1	-0.1	2.3	2.0	0.2	0.2	1.2	2.9	2.4	2.1	2.0	2.2	1.5	2.2	2.0	1.9	2.9
Number of live births	2.9	4.1	8.4	-2.2	-2.5	-0.3	-1.8	-1.7	-1.8	-0.8	-2.1	-2.5	-1.9	-1.9	-2.2	-1.5	-1.6	-2.4	-2.0	-2.9	-2.5
Health satisfaction	2.8	3.6	7.6	1.1	1.1	2.4	2.3	2.1	-1.9	-0.4	1.0	2.2	2.8	2.5	1.8	0.1	1.0	2.1	2.1	1.9	2.6
Time employed in main current job	2.7	3.1	9.9	3.2	0.5	-0.9	0.7	-0.1	1.5	0.1	2.1	1.3	1.6	1.4	2.7	0.8	2.1	1.8	2.8	2.6	1.2
Medication: Ibuprofen	2.7	3.2	12.9	-2.0	-1.9	-1.5	-0.6	-0.2	-1.4	-0.9	-2.4	-2.2	-1.3	-1.3	-1.6	-3.6	-2.3	-1.5	-1.1	-2.1	-1.8
Illnesses of siblings: Diabetes	2.7	3.4	11.6	-1.4	-3.4	-1.6	-2.5	-2.3	-1.3	-0.6	-2.1	-2.4	-1.7	-1.0	-1.6	-1.4	-1.1	-2.4	-0.6	-1.4	-1.9
Systolic Blood Pressure	2.6	13.0	39.7	-4.4	-1.5	-3.6	-3.1	-0.5	-6.3	-5.8	-4.5	-3.3	-1.8	-1.5	-3.4	-3.8	-2.2	-5.3	-2.4	-3.8	-1.3
Tinnitus: Yes, now most or all of the time	2.6	3.0	7.0	-2.6	-1.4	-1.2	-1.3	-0.8	-0.5	-0.3	-2.6	-1.3	-1.9	-1.6	-1.4	-1.6	-2.4	-1.6	-2.3	-2.0	-2.2
Lupus	2.4	3.6	8.8	2.9	0.2	3.0	-0.2	-1.6	0.5	0.2	2.6	-0.1	2.3	1.4	1.8	0.3	1.7	2.3	2.9	2.8	1.6
Age at first live birth	2.4	4.2	15.1	2.2	1.9	0.3	1.2	-0.2	3.9	2.9	2.5	2.4	1.0	0.7	1.6	2.8	1.2	3.1	1.2	2.4	0.8
Medication: Seretide 50 evohaler	2.4	2.8	7.7	2.6	-0.5	2.1	0.3	-0.9	-1.1	-0.5	1.9	1.1	2.0	1.3	2.8	1.8	2.3	-0.1	2.2	1.8	1.1
Age at last live birth	2.4	3.5	7.2	2.7	1.4	0.2	0.9	-0.1	2.7	2.2	2.4	2.0	1.3	1.1	2.3	2.5	1.3	2.7	1.7	2.1	0.5
Asthma (self-reported)	2.4	4.8	10.3	2.2	2.4	3.2	2.5	2.0	0.3	1.2	2.3	2.3	2.4	2.8	3.1	1.3	2.7	1.0	1.9	1.9	1.6
Pain type(s) experienced in last month: Hip pain	2.4	3.1	6.3	0.4	1.9	0.3	2.5	2.0	0.3	-0.8	0.8	2.0	2.5	2.3	2.5	-0.3	1.2	1.5	2.1	2.4	2.2
Medication: Ibuprofen (e.g. Nurofen)	2.3	3.0	9.4	-1.8	-2.0	-1.5	-0.8	-0.3	-1.7	-1.0	-2.4	-1.9	-1.2	-1.4	-1.5	-3.1	-2.1	-2.0	-0.7	-1.9	-1.7
Medication for pain relief, constipation, heartburn	2.3	4.0	19.6	2.6	1.8	0.7	0.4	-0.4	4.4	2.3	3.0	1.7	-0.2	0.0	1.3	3.3	2.0	1.8	0.8	1.7	0.7
Asthma	2.2	4.4	9.8	2.2	2.1	3.0	2.2	1.7	-0.1	0.9	2.2	2.1	2.4	2.8	3.1	1.2	2.7	0.8	2.1	1.9	1.5
Lung FEV1/FVC ratio	2.1	10.4	28.6	-2.9	-2.1	-1.4	-2.6	-1.6	-1.9	-0.8	-3.0	-2.3	-5.0	-4.3	-5.3	-0.6	-3.8	-3.1	-4.0	-4.9	-2.9
Hypothyroidism/myxoedema (self-reported)	2.1	4.2	13.4	2.5	2.1	0.9	1.3	0.7	2.8	0.1	2.6	1.5	1.8	1.5	2.6	0.7	2.2	1.8	2.6	3.7	1.7
Number of full brothers	2.1	2.7	10.5	-2.3	-0.9	-1.3	-0.3	1.0	-3.2	-0.4	-2.0	-1.0	-0.8	-1.3	-2.2	-1.6	-2.0	-0.9	-1.4	-2.6	-0.2
Respiratory disease	2.0	4.4	11.3	1.4	2.0	3.4	2.2	1.9	-0.8	-0.2	1.5	1.8	3.1	3.1	3.3	0.5	2.7	0.5	1.9	2.0	1.8
Schizophrenia (2018)	1.9	4.0	9.2	-2.8	-2.1	-1.5	-2.2	-0.6	-2.1	-0.2	-3.0	-1.7	-1.6	-1.3	-2.2	-2.4	-2.5	-1.2	-2.3	-2.3	-1.7
Mouth/teeth dental problems: Dentures	1.9	3.2	10.2	-2.2	-2.9	0.5	-1.3	-1.6	-3.2	-1.4	-2.0	-1.9	-0.6	-1.1	-1.2	-1.8	-1.8	-2.0	-1.4	-1.9	-0.9
Birth weight	1.9	4.2	16.8	-2.2	-1.0	-3.4	-0.6	0.7	-4.1	-3.7	-3.1	1.1	-0.3	-1.4	-1.4	-0.2	-2.5	-1.0	-1.1	-1.5	1.0
Eye problems/disorders: None of the above	1.9	2.2	8.1	0.8	2.0	-0.2	2.1	2.1	0.6	-0.8	0.5	2.8	0.7	0.4	-0.1	2.2	0.7	1.6	0.4	0.5	2.8
Mood swings	1.9	3.4	7.2	-2.1	-2.4	-0.4	-1.4	-0.7	-2.1	0.2	-2.3	-2.6	-1.4	-1.6	-1.7	-2.7	-2.5	-1.7	-1.2	-1.7	-1.9
Mother’s age at death	1.9	2.3	6.7	2.3	2.0	-1.0	1.3	0.4	2.6	1.7	2.4	1.4	-0.2	-0.9	1.3	2.5	1.8	-0.3	0.1	0.5	-0.4
Medication: Paracetamol	1.9	2.9	17.6	-1.8	-1.8	0.2	-0.4	-0.5	-2.6	-0.5	-1.9	-2.3	-0.4	-1.0	-1.2	-4.2	-2.2	-0.9	-0.2	-1.0	-1.5
Hearing difficulty/problems: Yes	1.8	2.7	13.5	-0.8	-3.7	0.7	-2.2	-2.4	-1.9	-1.0	-1.4	-1.8	-1.0	-1.6	-0.2	-1.1	-1.7	-1.7	-0.0	-0.7	-1.7
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	9.0	-0.5	1.0	0.1	1.3	2.0	-1.4	-2.3	-0.6	1.9	1.9	2.0	0.8	0.0	1.0	0.2	1.5	1.8	3.0
Systolic blood pressure, automated reading	1.8	5.2	15.4	-2.6	-0.4	-2.1	-1.3	-0.1	-3.9	-3.6	-2.8	-1.4	-1.6	-1.5	-2.5	-2.2	-1.0	-3.2	-2.5	-2.9	-0.6
Pulse wave peak to peak time	1.8	2.1	4.8	1.6	2.2	1.0	1.5	1.7	1.4	0.4	1.3	0.5	1.0	1.5	0.9	-0.7	1.4	1.8	2.2	1.9	1.6
Average weekly beer plus cider intake	1.8	2.6	9.2	-1.9	-1.6	-0.2	-0.7	-0.5	-2.0	-0.0	-1.6	-2.3	-1.4	-1.7	-2.0	-3.0	-2.2	-0.8	-0.5	-1.5	-1.3
Supplements: Vitamin C	1.7	2.0	6.5	-1.0	-0.5	-0.5	-0.6	-0.5	1.8	0.4	-0.6	-0.8	-2.3	-2.1	-1.0	-0.4	-1.4	-1.2	-2.5	-1.9	-2.5
Mineral and other dietary supplements	1.7	2.3	6.0	1.2	0.8	2.4	1.2	1.2	-1.5	-0.5	1.2	0.8	2.2	1.9	1.0	0.1	0.9	1.7	2.5	2.0	1.9
Bipolar Disorder (2018)	1.6	2.6	7.3	1.4	2.1	2.7	1.2	1.3	1.2	0.7	1.6	1.0	1.4	2.1	1.7	0.8	2.0	1.4	1.7	1.7	1.6
Ever had hysterectomy (womb removed)	1.6	1.8	3.7	-1.2	-1.2	-1.7	-0.3	-0.5	-0.7	1.0	-1.1	-0.9	-1.9	-1.8	-1.9	-1.2	-1.4	-1.4	-1.6	-1.7	-1.4
Hair/balding pattern: Pattern 2	1.6	2.1	6.8	2.3	0.1	1.1	0.2	-1.4	2.2	1.5	2.6	-1.1	1.0	0.2	1.2	-1.3	1.2	1.7	1.5	1.6	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	8.4	-1.5	-0.7	0.0	-0.8	-0.4	-2.9	-2.2	-1.5	-1.4	0.4	-0.8	-1.0	-1.6	-1.1	-2.1	-0.6	-1.3	-0.3
Blood clot in the leg (DVT)	1.6	2.0	4.2	1.4	1.9	0.8	1.3	1.6	1.1	-0.3	1.3	1.4	2.0	1.5	1.6	0.0	1.2	2.0	1.1	1.6	1.7
Age at First Birth	1.5	2.2	10.7	1.7	1.2	-0.1	0.3	-0.4	3.3	2.3	1.8	1.3	0.4	0.2	0.6	2.8	1.0	2.1	-0.0	0.6	0.7
Rheumatoid Arthritis	1.5	2.1	5.4	-1.5	-2.3	0.8	-2.2	-1.6	-0.6	0.1	-1.5	-1.0	-1.5	-1.8	-1.3	-0.3	-2.0	-0.8	-1.3	-1.5	-1.5
Serious illness, injury or assault to yourself	1.5	1.8	7.2	-0.0	0.4	1.5	0.2	1.1	-0.8	-1.3	-0.5	1.7	1.2	2.4	0.7	1.2	1.2	0.8	1.8	1.4	2.7
Medication: Paracetamol	1.5	2.5	11.4	-1.6	-1.8	-0.1	-0.3	-0.4	-3.4	-0.9	-1.8	-1.8	0.2	-0.8	-1.0	-3.4	-2.0	-1.0	0.1	-0.8	-0.8
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	7.1	0.6	-0.6	-1.6	-0.5	-1.5	2.7	1.3	0.6	-0.2	-2.2	-2.0	-0.9	1.3	-0.6	-0.3	-0.9	-0.7	-1.9
Average weekly red wine intake	1.5	2.1	9.5	2.6	0.2	-0.8	-0.2	-0.8	3.1	0.3	1.5	1.2	0.9	0.9	1.8	1.7	1.3	1.6	1.2	1.9	0.4
Schizophrenia (2014)	1.4	3.0	6.0	-2.2	-2.4	-1.6	-2.0	-1.1	-1.7	-0.1	-2.4	-1.3	-1.6	-0.8	-1.8	-1.7	-1.7	-1.1	-2.4	-2.0	-1.6
Diabetes (father)	1.4	1.7	4.2	1.1	1.9	0.9	1.5	1.8	1.3	-0.4	1.2	0.7	0.9	1.2	0.5	-0.9	0.6	2.0	1.8	1.7	1.5
Falls in the last year	1.4	1.9	6.0	0.6	0.2	0.5	2.0	1.1	-0.6	0.5	0.9	0.9	2.5	2.2	1.7	-0.6	1.4	1.5	1.5	1.5	1.7
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	6.8	0.5	1.0	0.3	0.8	1.7	-2.6	-1.3	-0.1	1.2	1.8	1.9	1.5	0.3	1.5	0.0	0.8	0.2	2.2
Medication: Amlodipine	1.4	1.9	3.6	-1.8	-0.7	-1.8	-1.1	-0.1	-0.7	-0.6	-1.9	-0.8	-1.8	-0.7	-1.9	-0.4	-1.4	-1.8	-1.8	-1.9	-1.3
Had major operations	1.4	1.6	4.8	1.0	0.8	0.4	-0.0	0.9	-0.2	-0.3	0.3	1.4	1.6	1.6	1.7	0.5	1.0	1.6	2.0	2.2	1.9
Pack years adult smoking proportion	1.3	2.0	9.5	-2.4	-0.2	0.0	0.0	1.2	-3.1	-2.0	-2.0	-0.7	1.0	1.6	-0.7	-1.6	0.1	-1.1	-0.8	-0.7	1.2
Age when periods started (menarche)	1.3	3.1	7.2	-2.5	-1.4	0.1	-1.7	-1.0	-0.7	-1.5	-1.9	-2.5	-1.4	-1.5	-1.7	-2.7	-1.9	-2.2	-1.4	-1.4	-2.0
Pulse wave Arterial Stiffness index	1.3	1.5	3.9	-1.3	-2.0	-1.0	-1.4	-1.7	-0.9	-0.3	-1.0	-0.2	-0.7	-1.4	-0.6	0.9	-1.2	-1.4	-1.8	-1.4	-1.4
Wheeze or whistling in the chest in last year	1.3	2.4	8.3	-0.2	1.8	2.0	2.4	2.8	-2.9	-1.5	-0.0	1.1	1.5	1.4	0.8	-0.8	1.0	-0.4	-0.2	-0.7	1.8
Neck or shoulder pain in last month	1.3	1.8	6.7	-1.2	-2.6	1.3	-1.0	-1.5	-2.3	-1.6	-0.9	-1.6	1.4	0.7	0.6	-1.9	-0.6	-0.7	0.3	-0.4	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	5.7	-1.7	-0.7	-0.7	-0.5	0.6	-2.4	-1.3	-1.5	-1.4	-0.5	-0.6	-0.7	-2.2	-1.5	-1.3	-0.3	-1.1	-1.0
Long-standing illness, disability or infirmity	1.3	1.9	7.2	-1.8	-0.0	-0.3	0.6	2.5	-2.7	-1.6	-1.9	1.1	1.2	2.0	0.0	-0.5	0.1	-0.6	0.5	0.5	2.0
Back pain experienced in last month	1.3	2.0	8.3	-2.2	-1.3	1.3	-0.3	0.4	-2.4	-1.5	-2.2	-0.6	0.6	0.2	-0.4	-2.9	-1.9	-0.2	-0.4	-0.7	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	3.5	1.3	1.7	0.7	1.2	1.4	1.0	-0.4	1.1	1.3	1.9	1.4	1.4	0.1	1.0	1.8	1.2	1.6	1.6
Pack years of smoking	1.3	1.9	8.1	-2.4	-0.4	-0.2	0.0	1.1	-2.8	-1.9	-2.0	-0.7	0.7	1.4	-0.8	-1.5	0.1	-1.5	-1.1	-1.0	0.9
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	4.6	1.9	-0.2	1.1	-0.1	-0.5	-0.1	0.6	1.8	-0.6	1.6	0.3	2.1	-0.3	1.2	1.0	1.9	1.1	0.1
Illnesses of siblings	1.2	1.7	5.8	0.8	1.8	-0.5	1.5	2.0	1.1	-0.9	0.4	2.4	0.5	0.6	1.0	1.9	0.4	0.5	1.7	1.4	1.6
Illnesses of mother	1.2	1.5	5.0	1.6	-0.1	1.2	0.8	0.2	0.7	0.6	1.3	0.4	1.3	1.6	1.0	-0.7	0.5	2.0	2.2	2.1	0.7
Birth weight of first child	1.2	2.2	12.4	-1.8	-1.3	-2.2	-0.7	0.8	-3.5	-2.2	-2.3	-0.1	0.2	0.4	-0.7	-0.8	-0.8	-1.7	-0.3	-0.7	1.0
Pulse wave reflection index	1.2	1.5	3.8	-1.4	-0.3	-1.6	-0.9	-0.6	0.4	0.5	-1.1	-0.5	-1.3	-1.8	-1.8	0.3	-1.4	-0.3	-1.9	-1.9	-1.1
Emphysema/chronic bronchitis	1.2	1.4	5.3	0.3	0.1	1.4	0.4	0.4	-1.2	-2.3	-0.1	0.3	1.9	1.7	1.8	-0.2	1.4	-0.5	1.3	0.9	0.7
Migraine (self-reported)	1.2	1.5	5.2	0.9	1.4	0.2	1.5	1.3	-0.4	-0.1	1.1	1.0	2.3	0.9	1.8	0.1	1.6	0.7	1.4	0.9	1.5
Pulse rate, automated reading	1.2	4.0	14.9	-1.5	-2.5	-0.1	-1.6	-1.5	-3.9	-3.2	-2.0	-1.0	-1.0	-1.3	-0.8	-0.8	-2.2	-3.1	-0.9	-1.6	-2.4
Number of full sisters	1.2	1.4	3.9	-1.9	-0.6	-0.9	-0.8	-0.1	-2.0	-1.8	-1.8	-0.4	-0.1	0.3	-0.7	0.1	-0.3	-2.0	-1.5	-1.6	-0.3
Knee pain experienced in last month	1.2	1.9	13.6	-0.6	-0.1	1.0	1.5	1.6	-3.7	-1.5	-1.0	1.0	1.3	1.0	0.2	-1.4	-0.2	0.1	0.8	-0.2	2.0
Illnesses of father: Heart disease	1.2	1.7	5.6	-1.9	-0.6	-0.2	-1.0	0.3	-2.2	-0.8	-1.7	-0.5	-1.0	-1.0	-2.4	-0.3	-1.5	-1.1	-1.4	-1.7	0.2
Eye problems/disorders: Cataract	1.2	1.4	6.0	0.2	-1.8	1.0	-1.0	-2.4	-0.8	-0.0	0.5	-1.2	0.8	0.5	1.9	-0.2	1.1	-1.7	0.5	0.2	-1.5
Ever taken oral contraceptive pill	1.2	1.3	3.4	0.6	-1.7	-0.2	-1.5	-1.9	-1.1	0.0	-0.1	-1.2	-1.2	-1.6	-0.5	0.3	-0.6	-1.8	-0.1	-1.1	-1.6
High cholesterol (Self-reported)	1.2	2.1	5.5	1.7	2.4	0.3	2.0	2.2	1.4	0.2	1.7	2.2	0.8	0.1	1.2	1.6	1.0	1.5	0.4	0.6	1.5
Pain experienced in last month	1.2	1.9	7.1	1.0	-0.0	-2.6	-1.1	-1.5	2.7	0.9	1.0	-0.9	-2.2	-1.9	-1.2	1.2	0.2	-0.4	-0.4	-0.1	-1.4
Relative age of first facial hair	1.1	2.2	5.9	2.0	0.5	0.2	0.8	-0.8	2.2	2.4	2.1	1.4	1.1	0.4	1.3	1.4	0.1	2.2	1.8	2.1	-0.3
Supplements: Zinc	1.1	1.2	3.8	1.0	1.9	-1.6	1.1	1.0	1.7	1.9	1.0	1.1	-0.4	-0.1	-0.0	0.6	0.3	1.5	-0.8	0.2	0.4
Qualifications: CSEs or equivalent	1.1	1.4	5.2	0.7	0.4	2.3	0.3	1.4	-2.2	0.1	0.4	0.5	1.2	1.3	0.8	0.1	0.5	0.4	2.2	1.0	1.4
Chronic bronchitis/emphysema (father)	1.1	1.3	4.3	0.2	0.9	-0.7	1.0	1.3	-1.5	-0.9	0.1	1.2	1.8	1.5	2.1	0.6	1.0	-0.3	0.9	0.5	1.1
Mouth/teeth dental problems	1.1	1.7	12.2	1.4	1.9	-1.7	0.8	0.6	3.5	1.3	1.5	0.6	-1.1	-0.9	-0.2	0.6	0.0	1.3	0.5	0.8	-0.7
Pain all over the body in last month	1.1	1.2	3.6	0.2	0.2	-0.6	0.8	1.2	-1.0	-1.1	-0.6	1.8	0.6	1.2	1.3	1.9	0.6	-0.3	1.5	0.9	1.4
Medication: Ramipril	1.1	1.4	4.1	-0.6	-0.0	-2.0	-0.6	0.2	-0.3	-1.0	-0.8	-0.6	-1.9	-1.6	-0.9	-0.2	-0.5	-2.0	-1.3	-1.8	-1.2
Medication: Lansoprazole	1.1	1.3	4.4	0.4	-0.3	2.0	0.1	-0.2	-0.3	-0.1	0.5	1.3	1.5	2.1	1.4	0.9	1.1	0.8	1.2	1.7	1.2
Supplements: Fish oil (including cod liver oil)	1.1	1.5	4.2	-1.5	-1.1	-1.0	-1.0	-0.8	1.1	-0.4	-1.6	-0.5	-2.0	-1.2	-0.9	-0.3	-0.7	-1.5	-1.7	-1.4	-1.5
Alzheimer’s Disease (including proxy)	1.0	1.5	3.7	-0.4	-1.4	-1.7	-1.4	-1.9	0.2	-0.7	-0.5	-0.1	-0.7	-1.1	0.0	1.9	-0.5	-1.3	-1.7	-1.8	-1.6
Supplements: Glucosamine	1.0	1.4	4.4	-1.5	-0.6	-1.8	-0.8	-0.2	0.3	0.3	-1.7	-0.0	-1.0	-1.0	-0.7	-0.6	-2.1	-0.6	-1.9	-1.3	-1.2
Number of incorrect matches in round	1.0	1.7	5.8	-0.7	0.7	-1.5	-0.0	0.8	2.0	2.0	-0.6	0.3	-1.5	-1.5	-1.0	-0.5	-1.7	1.1	-2.4	-1.3	-1.0
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	4.5	-1.2	0.9	0.1	0.5	2.1	-1.0	-1.5	-2.1	0.4	-1.1	0.2	-1.7	-1.5	-0.4	-1.0	0.5	-0.1	1.0
Happiness	1.0	1.2	4.1	1.1	1.1	1.1	0.7	0.4	-0.4	1.2	1.1	0.7	1.4	2.0	0.9	0.7	0.9	1.8	0.9	0.9	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.3	1.4	0.6	1.5	0.2	-0.9	1.8	0.9	1.8	1.1	-0.2	-0.5	0.8	1.7	0.8	1.0	-0.7	0.6	-0.9
Shortness of breath walking on level ground	1.0	1.2	5.1	-0.9	1.1	0.1	1.3	2.2	-2.0	-1.5	-1.1	0.3	0.2	0.4	-0.5	-1.2	-0.6	-0.4	-0.2	-0.6	1.2
Commuting to job workplace: Car/motor vehicle	1.0	1.1	5.2	0.6	1.4	0.4	0.6	1.2	-1.2	-2.3	0.2	0.1	0.8	0.7	0.6	-0.3	0.9	0.1	1.8	0.9	1.6
Ever had prostate specific antigen (PSA) test	1.0	1.1	5.4	0.2	-1.0	-2.3	-0.8	-1.1	1.2	0.3	-0.5	0.6	-1.1	-1.3	-0.4	1.2	-0.9	-1.0	-1.3	-0.8	-1.2
Alcohol drinker status: Previous	1.0	1.1	5.1	-0.8	-1.0	1.5	-0.0	-0.0	-2.2	-0.9	-0.7	-1.0	1.4	0.8	0.8	-2.3	0.1	-0.7	0.2	0.1	-0.1
Coronary Artery Disease (CAD)	0.9	1.0	3.7	0.9	1.9	0.3	1.4	1.4	0.5	0.1	1.3	1.0	1.2	0.8	1.2	0.7	1.0	0.9	0.7	0.6	0.7
Primary Biliary Cirrhosis	0.9	1.2	6.8	1.0	0.6	0.2	-0.3	-0.5	2.4	2.6	1.6	-0.2	0.6	-0.1	0.3	-0.4	0.1	1.8	0.2	1.4	-0.1
Vitamin and mineral supplements	0.9	1.3	7.7	0.0	-0.3	0.6	0.3	0.7	-2.8	-2.1	-0.3	0.4	1.3	1.2	0.4	-0.1	0.4	-0.6	1.5	0.9	1.5
Multivitamins +/- minerals	0.9	1.2	7.0	1.1	0.7	-0.4	0.2	-0.4	2.6	2.6	1.1	0.0	-0.4	-0.2	0.3	-0.1	0.4	1.7	-0.6	0.1	-0.5
High blood pressure (mother)	0.9	1.3	5.1	-0.7	1.3	-0.1	0.4	0.6	-0.1	1.1	-0.1	-0.6	-1.7	-1.6	-0.9	0.2	-0.6	-1.0	-2.3	-2.1	-1.5
Qualifications: None of the above	0.9	2.0	7.8	-1.9	-1.7	2.1	-0.3	-0.1	-2.8	-0.4	-1.1	-1.0	-0.2	-1.4	-0.5	-0.7	-1.1	-1.4	-1.6	-2.2	-0.7
Lung cancer (father)	0.9	1.0	4.8	1.8	-0.5	1.1	0.2	-0.7	-1.0	-0.2	1.3	0.1	1.8	0.1	2.2	0.6	1.2	-0.4	0.9	0.5	0.1
Medication: Ventolin 100micrograms inhaler	0.9	1.1	3.9	1.0	1.0	2.0	1.4	1.5	-0.9	-0.4	0.8	0.0	1.0	0.8	1.2	-1.0	1.1	0.0	1.5	0.3	0.6
High blood pressure (siblings)	0.9	1.3	4.7	-0.4	-0.0	-0.2	-0.4	-0.9	-0.0	1.9	0.2	-1.0	-1.0	-1.4	-1.3	-1.0	-1.0	0.7	-2.2	-1.7	-1.6
Commuting to job workplace: Walk	0.9	1.0	3.4	-0.2	-1.4	-0.5	-0.8	-1.3	0.8	0.9	-0.2	-0.3	-1.2	-1.1	-0.2	0.5	-1.1	-0.5	-1.7	-1.2	-1.8
Medication: Gliclazide	0.9	1.0	3.2	-0.9	-1.0	-1.4	-1.3	-0.9	-0.7	-1.1	-1.2	-0.4	-0.9	-1.0	-1.1	-0.1	-0.6	-1.8	-0.6	-0.7	-0.9
Wears glasses or contact lenses	0.9	1.0	3.4	1.1	-0.6	0.2	0.4	-0.8	1.6	1.1	1.3	0.7	0.6	1.1	1.4	1.4	1.8	-0.0	0.2	0.8	-0.1
Fractured/broken bones in last 5 years	0.9	1.2	4.9	-0.1	0.8	0.9	1.5	1.8	-2.2	-0.8	-0.2	0.5	1.2	1.5	0.5	-1.5	0.8	0.2	0.5	-0.0	1.3
Age started oral contraceptive pill	0.9	1.1	3.6	-0.3	0.2	-1.4	-0.4	-1.1	1.8	0.4	0.1	-0.7	-0.8	-1.0	-0.5	0.5	0.5	-1.6	-1.9	-0.8	-1.8
Heart disease (siblings)	0.9	1.1	2.9	-1.2	-1.3	1.2	-1.6	-1.4	-1.6	-0.5	-1.0	-1.7	0.1	-0.2	-1.2	-1.0	-0.1	-1.2	-0.1	-0.8	0.2
Schizophrenia vs Biploar Disorder	0.8	1.1	3.5	-0.8	-1.6	-0.5	-0.3	-0.7	-1.1	0.6	-0.9	-0.4	-0.9	-0.5	-1.4	-0.7	-1.5	0.3	-1.6	-1.9	-1.3
Ovarian Cancer	0.8	1.1	4.7	-0.1	1.1	1.9	1.3	2.2	-1.3	-0.4	-0.5	1.2	0.6	0.1	-0.2	-0.3	-0.8	0.5	1.1	0.4	1.5
Prostate Cancer	0.8	1.2	2.4	1.4	1.2	1.3	0.4	1.5	-0.9	1.0	1.2	0.8	1.1	1.0	0.3	0.2	0.7	1.5	1.3	0.8	1.5
LDL Cholesterol	0.8	1.3	5.4	0.7	1.5	-0.6	0.9	1.4	2.3	1.6	0.6	1.4	-1.6	-0.8	-0.7	1.4	-0.4	1.0	-0.1	-0.0	0.2
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.5	-0.4	0.8	-0.5	0.9	1.9	-1.4	-0.4	-0.6	1.5	0.9	-0.2	0.3	0.7	-0.5	-0.3	1.1	0.4	1.7
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.9	-0.3	-0.4	0.4	-1.2	-0.8	-0.2	0.9	-0.5	-0.3	-1.7	-1.5	-1.3	0.8	-0.5	-1.3	-0.6	-0.8	-1.3
Severe depression (siblings)	0.8	0.9	3.6	-1.9	-0.3	-1.0	-1.0	0.1	-0.8	-1.3	-1.4	-0.7	-0.3	0.3	-0.9	-0.9	-0.5	-1.0	-1.2	-0.7	-0.4
Townsend deprivation index at recruitment	0.8	1.1	4.2	-1.7	-1.2	-1.2	-0.1	1.1	-2.0	-0.5	-1.9	-0.3	0.6	0.5	-0.1	-1.6	-0.7	-0.8	-0.4	-0.6	0.7
Current tobacco smoking	0.8	1.3	8.5	-1.1	-0.3	0.9	0.3	1.1	-1.9	-1.0	-1.1	-1.3	-0.3	-0.7	-0.9	-2.9	-1.0	-0.9	-0.2	-0.8	-0.5
Average weekly fortified wine intake	0.8	1.0	3.1	0.9	-0.0	0.9	0.8	-0.0	0.1	0.3	1.0	0.7	1.4	1.6	0.9	0.0	1.8	0.3	1.2	1.2	1.3
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.7	0.1	0.3	-1.9	-0.3	-0.1	0.7	1.3	-0.4	0.5	-1.9	-1.5	-1.6	0.6	-1.0	0.2	-0.3	-0.3	-0.7
Exposure to tobacco smoke at home	0.8	0.9	6.8	-0.0	-0.7	-0.7	0.3	-0.4	-2.6	-1.9	-0.4	0.0	0.5	-0.5	0.5	-0.4	0.1	-0.7	-0.8	-1.2	-0.3
Breastfed as a baby	0.8	1.0	3.8	1.3	1.1	-0.8	0.3	0.0	1.5	0.7	0.8	1.0	-1.4	-1.7	-0.4	2.0	-0.3	0.1	0.1	-0.7	-0.4
Peak expiratory flow (PEF)	0.8	1.9	6.0	-1.1	-0.2	-2.3	-0.5	0.1	-1.1	0.7	-1.4	-0.7	-1.8	-1.1	-2.0	-0.6	-1.4	-1.0	-2.0	-2.5	-1.0
Overall health rating	0.8	1.7	7.4	0.2	1.6	1.7	1.9	2.7	-2.2	0.9	0.3	1.0	1.3	1.3	0.8	-0.4	0.8	0.1	0.6	0.2	1.7
Family relationship satisfaction	0.8	0.9	3.2	1.5	1.1	0.7	1.3	1.0	0.2	1.8	1.1	0.9	0.2	0.7	0.4	0.4	0.5	1.8	0.1	0.3	0.8
Handedness (chirality/laterality): Left-handed	0.8	1.0	4.2	0.6	1.9	0.6	0.8	2.0	0.2	0.4	0.6	-0.1	0.6	1.1	0.5	-0.9	0.8	1.2	0.7	0.8	1.3
Smoking status: Current	0.8	1.2	7.0	-0.9	-0.3	1.3	0.3	1.1	-1.8	-0.9	-1.0	-1.2	-0.5	-0.9	-1.0	-2.7	-0.9	-1.0	0.1	-0.7	-0.4
Financial situation satisfaction	0.8	0.9	4.1	-0.6	0.5	1.5	0.7	1.9	-2.0	0.4	-0.7	0.5	0.3	0.8	-0.9	-0.7	-0.4	0.3	0.8	0.1	1.3
Medication: Atorvastatin	0.8	1.0	5.0	-0.1	0.6	-0.7	0.8	2.2	-0.6	0.0	-0.7	1.9	0.1	0.8	-0.6	1.2	0.2	0.1	0.7	0.3	1.9
Illnesses of father: High blood pressure	0.8	1.0	3.3	-0.3	1.1	0.5	0.6	1.3	-0.6	1.3	-0.1	-1.1	-1.0	-1.1	-1.4	-1.8	-1.1	0.5	-0.7	-1.2	-0.3
Triglycerides	0.7	1.2	3.4	1.3	1.4	1.2	1.5	0.7	1.4	1.0	1.9	0.8	0.4	0.3	0.8	1.4	1.5	0.7	0.5	0.8	0.7
Hand grip strength (right)	0.7	1.9	6.1	-0.8	-2.1	-1.1	-2.3	-2.5	0.7	-0.3	-1.1	-1.3	-1.7	-1.4	-1.5	-0.0	-1.7	-0.7	-0.8	-0.8	-1.4
High blood pressure	0.7	1.9	4.8	-1.4	2.0	-1.4	0.2	1.2	0.8	0.7	-0.8	-0.6	-2.1	-1.5	-2.2	-1.6	-1.4	-0.1	-1.9	-1.4	-0.7
Impedance of leg (left)	0.7	3.3	8.1	-2.2	-2.8	-0.8	-2.2	-1.6	-2.3	-2.7	-2.5	-2.1	-0.5	-0.6	-0.8	-1.1	-1.9	-2.5	1.3	-0.5	-0.9
Heart attack	0.7	0.9	3.4	0.5	1.8	0.1	0.6	1.6	-0.2	-0.9	0.4	1.3	0.5	0.9	-0.2	1.5	1.1	-0.0	0.4	0.6	1.7
Length of working week for main job	0.7	0.8	3.5	-0.5	-1.2	-0.5	-0.7	0.1	-0.9	-0.9	-1.1	-1.1	-0.6	0.5	-1.2	-1.9	-0.9	-0.1	0.7	0.2	0.4
Headache pain in last month	0.7	1.2	6.5	-1.2	-0.7	1.1	-0.1	0.3	-2.3	-1.1	-1.1	-0.8	1.5	1.0	0.6	-2.5	-0.5	-0.3	0.6	0.4	0.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	6.9	0.9	-1.2	2.6	0.2	-0.7	-0.2	0.4	0.8	-0.8	1.3	0.9	1.2	-1.2	0.6	0.9	1.4	1.0	-0.2
Exposure to tobacco smoke outside home	0.7	0.9	3.7	0.5	-0.9	1.9	-0.5	-1.1	-1.5	0.1	0.8	-1.1	0.8	-0.2	1.2	-0.6	1.0	-1.2	0.7	0.3	-0.3
Medication: Blood pressure	0.7	1.3	8.8	-1.4	1.4	-3.0	0.0	1.3	-0.2	-1.0	-1.4	0.9	-1.0	-0.1	-1.3	0.5	-0.8	-0.8	-1.1	-0.5	0.4
Alcohol intake frequency.	0.7	1.7	5.2	-0.8	1.1	1.8	1.4	1.4	-1.9	-0.5	0.0	-0.5	2.3	1.7	1.4	-1.5	1.5	-1.0	-0.2	0.3	1.1
Medication: Aspirin	0.7	0.9	4.4	-0.4	1.0	-1.1	0.0	1.6	-1.3	-2.1	-0.9	0.9	0.4	0.7	0.2	0.9	0.1	-0.9	0.2	0.2	1.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.8	-1.7	-1.7	0.7	-1.4	-1.1	-1.2	0.0	-2.0	-0.2	-0.0	0.2	-0.8	0.0	-1.3	-0.3	-1.4	-1.1	-0.1
Number of self-reported non-cancer illnesses	0.7	1.3	6.6	0.3	2.2	1.1	1.8	2.6	-0.3	-0.3	0.2	1.6	0.4	0.6	0.5	-0.2	0.9	0.2	0.8	0.6	1.6
Basal cell carcinoma (self-reported)	0.7	0.9	4.3	-0.5	-1.3	-0.3	-0.6	-1.5	-1.0	-2.1	-0.5	-0.5	0.2	-1.1	0.3	-0.3	-1.0	-1.1	0.7	-0.1	-0.9
Mean Putamen Volume	0.6	0.7	1.9	-1.4	0.2	1.4	0.4	1.2	-1.0	-0.9	-1.1	-0.6	-0.2	-0.1	-0.8	-0.6	-0.1	-1.1	-0.2	-0.8	-0.2
BMI	0.6	3.3	6.3	1.6	2.5	1.5	1.6	2.5	0.5	2.0	1.8	2.2	1.5	2.0	1.3	0.8	1.8	2.4	1.3	1.7	2.4
Number of treatments/medications taken	0.6	1.1	4.1	-1.6	-0.1	-0.5	0.4	1.2	-2.0	-0.9	-1.8	0.1	-0.4	-0.4	-0.7	-1.4	-1.0	-1.3	-0.6	-1.3	0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.5	-1.3	0.0	-1.4	0.1	0.5	0.6	-0.4	-0.7	-0.7	-0.6	-0.5	-0.7	-1.1	0.2	-1.6	-1.4	-0.9	-0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.6	-0.8	-0.4	0.7	-0.1	0.5	-0.1	-0.2	-0.6	-1.0	-1.6	-0.7	-1.2	-0.9	-0.3	-1.6	-0.6	-0.9	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	4.2	-0.4	-0.4	-0.2	0.1	-0.2	-1.3	-2.0	-0.2	-0.4	2.0	1.7	0.6	-1.9	0.6	0.7	1.3	1.6	1.5
Alcohol usually taken with meals	0.6	1.0	7.4	1.5	-0.0	-1.0	-1.1	-1.1	2.7	0.8	0.9	-0.1	-0.2	-0.3	0.5	1.2	0.8	0.2	0.3	1.1	-0.7
Hearing difficulty/problems with background noise	0.6	1.0	2.7	0.7	-0.2	1.3	0.7	0.5	-0.2	-0.1	0.2	1.3	1.0	1.4	1.6	1.2	1.2	0.2	0.9	1.3	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.1	0.0	0.7	-0.0	1.4	1.8	0.3	1.1	0.3	1.0	1.2	1.3	1.2	0.1	0.5	1.0	0.9	0.8	1.4
Hair/balding pattern: Pattern 3	0.6	0.9	3.0	-1.0	-0.5	-1.4	-0.2	-0.2	-1.5	-1.7	-1.1	-0.8	-0.4	-0.7	-1.0	-1.4	-0.5	-1.5	-0.3	-0.5	-0.6
Qualifications: College or University degree	0.6	1.8	12.8	1.1	-0.0	-1.5	-1.3	-1.9	3.6	0.0	0.4	-0.0	-0.4	-0.4	-0.9	0.2	-0.6	1.3	1.5	2.3	-0.2
Mouth/teeth dental problems: Loose teeth	0.6	0.7	3.2	-1.0	-1.0	0.4	-0.4	0.2	-1.8	-0.8	-1.7	0.5	-0.4	-0.4	-0.5	0.5	-0.4	-0.5	-0.1	-0.5	1.2
Heart disease (mother)	0.6	0.7	2.0	-1.2	0.3	-1.4	-0.7	0.4	-1.2	-1.0	-1.4	-0.3	0.1	0.6	-0.7	-1.2	0.3	-0.9	0.1	0.2	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.4	0.9	0.2	1.5	0.5	-0.1	-0.4	0.2	0.6	1.6	0.3	0.8	1.1	1.5	1.0	0.4	0.2	0.4	0.7
Ever had bowel cancer screening	0.6	0.7	4.1	-0.7	-0.1	-2.0	-0.1	-0.2	-0.3	-1.4	-0.7	0.6	0.8	0.1	0.6	-0.2	0.6	-1.4	-1.0	-0.0	0.2
Unable to work because of sickness or disability	0.6	0.7	5.4	-0.9	0.1	-0.9	0.9	0.8	-2.3	-0.7	-0.5	0.0	1.0	-0.0	0.5	-1.0	-1.1	0.1	-0.3	-0.5	0.5
Commuting to job workplace: Cycle	0.6	0.7	2.0	-0.8	-1.4	0.6	-1.0	-1.2	-1.3	-0.5	-0.8	-0.8	-0.3	-0.9	-0.8	-0.3	-1.0	-0.7	-0.1	-0.8	-0.1
Myopia	0.6	0.8	3.3	0.9	0.6	0.4	0.2	-0.4	1.8	1.0	1.1	0.9	0.6	1.0	0.4	1.8	1.2	0.7	-0.0	0.5	0.4
Cholesterol lowering medication	0.6	1.0	3.5	0.1	0.3	1.9	0.5	1.5	-1.0	-0.9	-0.2	1.0	1.5	0.7	1.1	0.0	0.6	0.1	0.9	0.4	1.6
Supplements: Calcium	0.6	0.7	4.4	-0.9	-0.2	-2.1	-0.7	-0.3	0.7	-0.1	-0.7	0.3	-0.4	0.5	0.6	1.3	0.7	-1.6	-0.2	0.1	-0.5
Alzheimer’s Disease (in mother)	0.5	0.6	3.1	-0.0	0.4	-1.8	0.2	0.4	0.4	-1.1	-0.4	1.2	0.0	-0.3	0.4	1.7	-0.3	-0.4	-0.6	-0.6	-0.3
Crohns Disease (2017)	0.5	1.2	4.0	0.7	0.7	0.2	0.9	0.9	-1.3	-1.4	0.2	1.3	1.9	1.0	1.3	-0.0	0.8	0.8	0.9	0.7	2.0
Reaction Time	0.5	0.9	4.8	1.2	0.5	0.7	1.0	0.0	0.2	2.2	1.9	-0.0	0.0	-1.0	0.5	0.8	0.7	0.2	-1.0	-1.0	-0.4
Breast Cancer	0.5	1.3	4.9	-1.3	1.0	1.3	0.9	2.2	-1.3	-2.1	-1.0	0.6	0.6	1.6	-0.4	-0.7	0.1	-0.1	0.2	0.1	1.4
Neuroticism (2016)	0.5	0.8	2.5	-1.5	0.3	0.2	0.4	0.8	-0.1	-0.4	-0.9	-0.2	-0.7	-1.4	-0.6	-0.7	-1.6	-0.5	-1.4	-0.9	-0.9
Smoking Status	0.5	1.1	2.1	-1.4	-0.9	-0.2	-1.1	0.6	-1.1	-0.6	-1.4	-0.8	-1.1	-1.4	-1.0	-1.3	-1.0	-1.1	-1.0	-1.2	-0.5
Cardiovascular Disease	0.5	1.7	4.1	-1.8	0.2	-1.1	-1.1	-0.1	-1.1	-1.0	-1.1	-1.6	-1.2	-1.3	-1.8	-2.0	-1.6	-1.0	-1.4	-1.6	-0.7
Sensitivity / hurt feelings	0.5	0.9	3.6	0.8	0.9	1.9	1.6	1.3	0.3	1.5	0.8	0.2	0.4	0.4	0.5	-1.3	0.8	0.6	0.4	0.3	0.9
Angina	0.5	0.6	2.6	-0.6	0.5	-1.6	0.1	1.3	-0.8	-0.5	-0.8	1.0	0.2	0.5	-0.4	1.0	0.3	-0.6	-0.6	-0.4	1.1
Impedance of leg (right)	0.5	2.3	6.3	-1.5	-2.5	-0.5	-1.8	-1.6	-2.1	-2.4	-1.8	-1.9	-0.1	-0.4	-0.3	-1.0	-1.6	-1.7	1.7	-0.2	-0.7
Stomach or abdominal pain in last month	0.5	0.7	2.4	-1.2	0.6	1.2	0.2	1.0	-0.2	-0.8	-0.7	0.6	0.9	1.6	0.0	0.0	-0.6	0.8	0.4	0.6	1.1
Medication: Atenolol	0.5	0.6	2.1	-0.7	0.8	-1.3	0.1	0.9	0.7	1.5	-0.5	0.4	-0.8	-0.5	-1.2	-0.3	-0.8	0.1	-0.7	-0.2	0.3
Waist circumference	0.5	1.9	4.5	1.2	1.7	1.6	1.8	1.7	0.2	2.1	1.8	1.3	0.6	0.8	0.9	0.5	0.8	2.0	0.7	1.0	1.6
Nervous feelings	0.5	1.0	3.2	-1.4	-0.8	-0.4	-0.3	-0.5	0.1	1.1	-0.7	-1.8	-0.8	-0.2	-1.0	-1.3	-0.7	-1.0	-0.9	-1.4	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	7.1	-0.2	-0.9	0.4	-0.2	-0.6	-0.8	-1.5	-0.2	-1.0	1.4	1.0	0.1	-2.7	-0.2	1.0	1.2	1.2	0.6
Financial difficulties in last 2 years	0.5	0.6	3.3	-1.0	0.0	-0.1	0.3	1.1	-1.5	0.2	-0.9	-0.1	0.8	1.8	0.3	-1.0	-0.0	-0.1	0.3	0.2	0.6
Medication: Cholesterol lowering	0.5	0.7	3.6	-0.2	0.7	-1.9	-0.4	0.3	0.5	-0.4	-0.4	0.6	-1.2	-1.0	-0.7	1.4	-0.3	-0.9	-1.2	-0.8	-0.2
Depression (self-reported)	0.5	0.6	3.0	0.4	-0.3	0.6	0.4	-0.0	-0.9	-1.0	0.5	0.6	1.4	0.8	1.7	1.1	0.8	-0.2	0.6	0.4	0.8
Prospective memory result	0.5	0.7	2.5	0.7	0.6	0.5	0.9	0.6	0.5	1.1	0.9	0.8	0.8	0.7	0.6	0.1	0.6	1.6	1.2	0.9	0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.0	0.9	0.6	0.8	0.6	0.4	-0.3	0.6	1.0	0.3	0.8	0.2	0.9	0.6	-0.0	1.4	1.3	0.3	0.8
Glaucoma (self-reported)	0.5	0.6	1.9	0.9	1.4	-1.2	0.3	0.9	-0.3	0.1	0.5	-0.0	0.4	0.8	0.3	-0.9	1.1	0.2	0.8	0.9	0.6
Gout (self-reported)	0.5	0.6	2.7	-0.3	0.1	-0.7	-0.1	0.0	0.6	0.5	0.1	-0.4	-1.6	-1.3	-1.1	0.2	-0.5	-0.1	-1.3	-1.4	-0.8
Forced vital capacity (FVC), Best measure	0.5	1.8	5.4	0.9	0.6	0.6	0.5	-0.1	0.8	1.0	1.0	0.6	1.6	2.0	1.3	0.3	0.7	2.2	2.3	2.3	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.1	-0.3	-0.5	0.1	0.7	-0.2	-0.6	-0.4	0.2	0.9	1.4	1.2	1.4	0.9	1.4	-1.3	-0.2	0.5	0.6
Angina (self-reported)	0.5	0.7	2.1	-0.6	0.5	-1.4	0.2	1.4	-1.0	-0.7	-0.7	1.1	0.4	0.7	-0.1	1.1	0.6	-0.7	-0.5	-0.2	1.3
Mean time to correctly identify matches	0.5	1.0	3.9	0.9	0.5	-0.3	0.6	-0.1	0.8	2.0	1.6	0.4	-0.4	-1.2	0.6	1.4	0.9	-0.3	-1.4	-1.0	-0.8
Chest pain or discomfort	0.5	0.7	2.4	0.0	0.1	-0.2	0.4	0.8	-1.3	-1.0	-0.3	1.0	1.5	1.1	0.6	0.2	0.7	-0.6	1.0	0.7	1.6
Hypertension (Self-reported)	0.5	1.5	3.5	-1.4	1.9	-1.5	0.3	1.2	0.7	0.3	-0.8	-0.5	-1.6	-1.0	-1.8	-1.7	-1.0	0.0	-1.7	-1.2	-0.4
Osteoporosis (self-reported)	0.5	0.6	3.5	-0.6	-0.5	0.9	-0.9	-0.4	-1.9	-1.4	-0.3	-0.6	0.3	-0.4	0.2	0.1	0.1	-1.4	0.0	-0.3	-0.1
Medication: Aspirin	0.5	0.6	2.3	-0.4	0.6	-1.5	-0.4	1.4	-1.3	-1.4	-1.0	0.3	-0.3	0.0	-0.3	0.5	-0.4	-0.9	-0.0	-0.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.0	-1.3	-1.7	-1.6	-1.3	-1.0	-0.7	0.2	-1.4	0.2	-0.7	-1.1	-0.8	1.5	-1.1	-1.1	-0.3	-0.8	-0.5
Medication: Lisinopril	0.5	0.7	3.1	-1.1	0.6	-1.8	0.2	0.2	0.1	-0.0	-0.6	-0.0	-0.3	-0.3	-1.0	0.0	-0.8	-0.6	-1.7	-1.1	-0.8
Arm fat-free mass (left)	0.5	2.4	7.5	1.9	2.2	2.0	1.3	1.0	1.7	2.0	2.2	1.6	0.6	0.5	1.3	1.0	0.8	2.7	0.2	1.2	1.0
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.1	1.3	-2.0	1.4	-0.0	-1.3	-0.7	-0.3	0.8	0.2	1.6	1.1	2.0	0.9	1.1	0.1	2.0	1.3	0.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.2	0.2	1.4	-0.0	0.5	1.5	-0.6	-0.9	-0.0	1.0	-0.0	0.5	-0.7	1.1	0.6	-0.3	0.0	0.1	1.3
Impedance of whole body	0.5	2.7	6.2	-2.1	-2.5	-1.9	-2.2	-1.5	-1.6	-1.9	-2.2	-2.3	-0.7	-0.6	-1.1	-1.2	-1.6	-2.0	0.7	-0.6	-1.0
Arm predicted mass (left)	0.5	2.7	8.8	1.9	2.5	1.8	1.5	1.3	1.6	2.1	2.2	1.8	0.8	0.8	1.3	1.0	0.8	3.0	0.2	1.3	1.4
Depressed Affect (Nagel 2018)	0.4	0.9	3.2	-1.8	-1.7	-0.2	-0.9	-0.4	-0.7	-0.9	-1.8	-0.5	-0.3	-0.1	0.1	-0.3	-1.1	-1.3	-0.8	-0.8	-0.7
Depression (Nagel 2018)	0.4	0.6	2.7	-1.6	-0.8	-0.7	0.2	0.3	-0.9	-0.6	-1.2	-0.8	0.2	0.8	-0.2	-1.4	-0.7	-0.7	-0.5	-0.4	-0.1
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.1	1.5	0.8	0.6	-0.1	-1.1	1.5	1.4	1.4	0.5	-0.8	-0.6	-0.1	1.8	0.7	0.1	-0.1	0.6	-0.4
Fasting Glucose	0.4	0.5	1.7	-0.0	-1.3	-0.4	1.1	-1.3	-0.3	-0.5	-0.1	0.3	0.9	0.7	0.5	-0.9	0.3	0.3	0.8	0.5	0.1
HbA1C	0.4	0.4	1.4	-0.8	-0.8	-0.5	-0.7	-0.4	-0.6	-1.2	-0.9	0.7	0.4	0.1	-0.5	1.0	-0.3	-0.3	0.3	0.6	0.7
HDL Cholesterol	0.4	0.7	1.9	-0.9	-1.3	-0.9	-1.4	-0.7	-0.0	0.1	-1.3	-0.5	-1.0	-0.7	-0.6	-0.8	-1.1	-0.6	-0.2	-0.2	-0.8
Waist Hip Ratio (WHR)	0.4	2.0	5.7	0.1	0.6	2.4	0.9	1.2	-0.1	0.6	1.2	0.8	2.1	1.6	1.3	-0.4	0.5	2.1	2.0	1.9	1.7
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.0	-1.4	-0.7	1.1	0.1	0.8	-0.3	1.2	-1.1	0.2	0.3	1.3	-0.2	-0.5	-0.8	0.5	-0.1	0.1	0.6
Medication for hormone replacement therapy	0.4	0.5	1.8	-0.6	0.5	-0.4	0.7	1.2	-0.8	-1.4	-0.7	0.6	0.1	0.7	0.3	-0.1	0.3	-0.8	-0.7	-0.8	0.2
Medication: Metformin	0.4	0.6	2.0	-0.2	0.1	-0.8	-0.1	1.1	-0.9	-0.7	-1.0	1.4	-0.1	0.6	0.0	1.0	0.3	-0.8	0.4	0.3	1.4
Leg fat-free mass (left)	0.4	2.3	9.0	1.8	2.3	0.5	1.5	1.1	1.9	2.5	2.2	1.4	0.2	0.3	0.5	0.6	0.7	3.0	-0.2	0.9	1.0
Maternal smoking around birth	0.4	0.5	1.6	0.3	-1.0	-0.5	-0.4	-0.5	-1.3	-1.3	-0.2	-0.6	0.6	0.5	0.8	-0.3	0.3	0.2	1.2	0.4	1.0
Fed-up feelings	0.4	0.7	2.8	-1.7	-0.9	0.3	-0.4	0.2	-1.4	-0.8	-1.4	0.0	0.9	0.5	0.4	-0.6	-1.1	-0.7	0.1	0.3	0.4
Taking other prescription medications	0.4	0.5	2.6	-0.9	-0.6	1.0	-0.2	0.5	-1.6	-0.7	-1.0	-0.1	-0.2	0.0	-0.1	-0.3	-0.1	-1.2	-0.7	-0.9	0.2
Leg predicted mass (left)	0.4	2.2	8.5	1.8	2.3	0.5	1.4	1.1	1.9	2.5	2.2	1.3	0.2	0.3	0.5	0.6	0.7	2.9	-0.3	0.9	0.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	2.5	0.6	0.7	-0.8	0.6	0.4	-0.0	0.6	0.6	1.0	0.5	0.1	0.8	1.6	0.3	0.6	0.8	-0.0	0.5
Allergy	0.4	1.0	3.9	-0.1	-0.5	-1.5	-0.7	-1.1	0.6	1.1	0.3	-0.3	-0.9	-2.0	-1.1	0.5	-1.4	1.0	-1.4	-0.9	-0.7
Trunk fat-free mass	0.4	2.4	8.4	2.2	2.3	1.8	1.5	0.8	2.0	1.8	2.2	1.7	0.4	0.3	1.0	0.8	0.5	2.9	0.0	1.2	0.7
Pulse rate	0.4	0.7	3.6	-0.5	-0.3	0.2	0.8	0.3	-1.9	-0.5	-0.4	1.0	-0.7	-0.6	-0.6	0.8	-1.2	-0.4	-1.1	-1.2	-0.3
Noisy workplace	0.4	0.5	2.0	-0.3	0.5	0.8	0.3	1.4	-0.8	-0.2	-0.7	1.1	0.2	0.3	0.0	1.0	-0.1	-0.1	-0.5	-0.9	0.8
Impedance of arm (left)	0.4	2.0	5.7	-1.7	-2.0	-2.4	-1.7	-1.2	-1.1	-1.4	-1.8	-1.9	-0.8	-0.7	-1.4	-1.2	-1.4	-1.4	0.1	-0.7	-0.8
Arm fat mass (right)	0.4	1.8	8.5	1.8	1.3	0.9	1.0	1.2	0.3	2.9	1.6	1.5	0.2	0.4	0.6	1.2	0.8	2.3	0.3	0.6	1.4
Trunk predicted mass	0.4	2.4	8.7	2.2	2.3	1.8	1.5	0.8	2.0	1.7	2.2	1.7	0.4	0.3	1.0	0.7	0.5	2.9	0.1	1.2	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.8	-1.5	-1.0	1.7	-0.0	-0.8	-0.2	0.3	-0.6	-0.6	-0.3	-0.0	0.0	-0.1	-0.2	-1.1	-1.3	-0.8	-0.7
Chronic bronchitis/emphysema (mother)	0.4	0.4	2.8	-0.5	-0.1	-0.3	-0.1	0.3	0.2	-0.6	-1.0	1.4	-0.7	0.0	-0.3	1.7	-0.3	-0.3	-0.2	-0.2	0.6
Arm fat-free mass (right)	0.4	2.0	6.6	1.8	2.0	1.7	1.0	0.7	1.8	2.0	2.1	1.3	0.4	0.3	0.9	0.8	0.5	2.6	0.3	1.2	0.9
Worry too long after embarrassment	0.4	0.6	2.6	-0.8	-0.6	-1.0	-0.5	-0.6	-0.9	-0.4	-0.7	-0.3	-0.2	-0.7	-1.3	0.2	-0.3	-1.6	-0.8	-0.7	-0.1
Medication: Allopurinol	0.4	0.5	1.4	-0.5	0.1	-0.8	-0.3	0.2	0.9	0.9	-0.1	-0.9	-1.0	-0.4	-0.4	-0.8	-0.3	0.1	-1.1	-1.2	-1.2
Suffer from ‘nerves’	0.4	0.6	3.2	-0.5	-1.3	0.6	-0.1	-1.2	1.0	1.8	0.3	-0.7	0.1	0.4	0.6	0.4	0.2	-0.4	-0.3	-0.5	-1.2
Smoking status: Previous	0.4	0.5	3.1	0.0	-0.6	-1.8	-0.4	-0.6	0.7	0.6	0.0	0.7	-0.6	-0.4	0.4	1.5	0.4	-0.6	-0.7	-0.6	-0.1
Whole body fat-free mass	0.4	2.3	8.3	2.0	2.3	1.4	1.4	1.0	1.9	2.0	2.2	1.6	0.3	0.3	0.8	0.7	0.6	2.9	-0.1	1.0	0.8
Leg fat-free mass (right)	0.4	2.0	7.6	1.5	2.4	0.4	1.4	1.2	1.9	2.3	1.9	1.4	0.2	0.3	0.3	0.6	0.5	2.8	-0.4	0.8	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.6	1.3	0.8	-0.0	-0.1	0.1	0.6	-0.3	1.0	0.3	-0.1	-0.0	0.6	0.7	0.7	0.6	1.2	0.6	0.4
Whole body water mass	0.4	2.5	8.8	2.1	2.4	1.5	1.4	0.9	1.9	2.0	2.3	1.6	0.4	0.4	0.9	0.8	0.7	3.0	-0.0	1.1	0.9
Leg predicted mass (right)	0.4	2.0	7.5	1.4	2.4	0.4	1.4	1.3	1.9	2.3	1.9	1.4	0.2	0.3	0.3	0.5	0.5	2.7	-0.5	0.8	0.9
Arm fat mass (left)	0.4	1.5	9.3	1.7	1.0	0.9	0.7	0.8	0.3	3.0	1.6	1.3	0.0	0.1	0.4	1.1	0.6	2.2	0.2	0.4	1.1
Commuting to job workplace: Public transport	0.4	0.5	1.7	0.4	-0.0	0.0	-0.0	-0.0	1.1	1.0	0.4	0.5	1.1	1.1	0.9	0.1	0.8	0.8	0.6	1.3	0.6
Medication: Blood pressure	0.4	0.8	3.4	-0.6	1.0	-1.9	0.0	0.7	0.7	0.0	-0.4	-0.2	-1.1	-1.0	-0.7	-1.0	-1.0	-0.0	-1.3	-0.8	-0.7
Alcohol drinker status: Never	0.4	0.5	1.9	1.0	0.6	1.4	0.6	-0.1	-0.4	0.0	1.1	-0.5	0.6	0.1	0.1	-1.1	0.9	0.0	0.4	0.7	0.4
Basal metabolic rate	0.4	2.4	8.9	2.0	2.3	1.4	1.5	1.1	1.7	2.3	2.2	1.6	0.4	0.4	0.9	0.8	0.6	3.0	-0.0	1.0	1.0
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.0	1.3	1.3	-1.0	0.1	-0.3	1.7	1.7	1.3	0.4	-0.8	-1.0	-0.5	1.5	0.7	-0.2	-0.4	0.1	-0.4
Major Depression (MDD)	0.3	0.4	4.6	0.0	0.0	0.0	0.0	2.2	0.0	-1.4	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.3	0.3	0.8	0.5	-0.9	0.5	-0.0	-0.5	0.6	0.8	0.7	-0.4	-0.2	0.1	0.5	0.6	0.6	-0.6	-0.0	-0.2	-0.5
Body Mass Index (BMI) (2010)	0.3	0.4	2.0	-0.0	-0.4	-0.0	-0.7	-0.9	-0.6	-1.4	0.1	-0.2	1.1	0.8	0.8	-0.0	0.7	-0.1	-0.4	0.3	0.2
Blood Eosinophil Count	0.3	2.2	16.9	-0.7	-0.2	0.1	-0.2	0.6	-4.1	-2.7	-0.8	-0.3	1.5	1.0	1.0	-0.8	0.7	-2.2	1.2	0.3	1.2
Blood Platelet Count	0.3	3.7	19.1	2.8	0.2	4.4	0.2	-0.2	1.3	2.0	2.0	1.8	0.7	1.4	2.0	2.9	2.0	1.1	2.1	1.4	0.7
Chronotype (morning person)	0.3	0.6	2.4	-1.5	0.7	-0.3	0.8	1.3	-0.2	-0.7	-0.8	-0.5	-0.2	-0.4	-0.7	-1.6	-1.2	0.2	-0.5	-0.0	0.2
Medication: Co-codamol	0.3	0.3	1.3	-0.4	0.1	1.0	0.5	0.5	-1.0	0.5	-0.3	-0.7	-0.4	-0.1	-0.3	-0.5	-0.2	-0.2	1.2	-0.1	0.4
Diabetes (mother)	0.3	0.3	2.1	-0.2	-0.3	1.4	0.1	0.2	-1.2	0.1	-0.2	-0.4	0.0	-0.5	-0.8	-0.4	-0.1	-0.5	-0.4	-0.5	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.4	-1.2	-0.5	-0.5	0.3	0.5	-0.9	-0.6	-1.0	-0.4	0.3	0.6	-0.1	-1.0	-0.8	-0.2	-0.0	-0.2	0.4
Relative age voice broke	0.3	0.5	2.4	0.7	-1.0	0.1	-1.1	-1.5	-0.5	0.4	0.2	-0.7	0.0	-0.5	0.4	0.8	-0.4	-0.1	0.8	-0.2	-0.7
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.3	-0.9	-0.1	0.1	-0.2	0.7	-0.5	-1.5	-1.2	-0.8	-0.5	-0.0	-0.5	-1.4	-0.2	-1.5	0.4	-0.1	-0.3
Body mass index (BMI)	0.3	1.2	7.9	1.0	1.0	1.0	1.0	1.1	0.2	2.8	1.2	1.3	-0.1	0.1	0.3	1.0	0.6	1.4	-0.5	-0.0	0.8
Medication: Simvastatin	0.3	0.4	2.6	-0.4	0.7	0.1	-0.1	0.7	-0.8	-1.6	-0.4	0.1	0.2	-0.7	0.6	-0.1	-0.2	-1.0	-0.7	-0.6	-0.1
Fluid intelligence score	0.3	0.6	1.7	1.1	0.5	0.1	-0.6	-0.9	0.7	1.1	0.9	-0.5	-1.3	-1.2	-1.1	0.6	-0.4	0.3	-0.5	-0.3	-0.4
Weight	0.3	1.7	6.9	1.5	1.7	0.8	1.0	0.9	1.2	2.6	1.8	1.5	0.0	-0.0	0.5	1.2	0.4	2.2	-0.3	0.6	0.9
Impedance of arm (right)	0.3	1.3	3.5	-1.3	-1.8	-1.9	-1.4	-1.0	-1.2	-1.3	-1.5	-1.5	-0.2	-0.0	-0.5	-1.0	-0.9	-1.0	0.4	-0.3	-0.5
Hip circumference	0.3	1.1	3.5	1.6	1.7	1.0	0.9	1.2	0.3	1.9	1.5	1.1	-0.2	-0.0	0.3	0.7	0.3	1.6	0.4	0.6	1.0
Father’s age at death	0.3	0.4	3.1	0.5	0.1	-0.4	-0.4	-0.3	1.8	0.0	0.4	0.3	-0.7	-0.7	0.2	0.7	-0.3	0.3	-0.5	-0.3	-0.9
Worrier / anxious feelings	0.3	0.5	3.3	-0.1	0.4	1.8	0.4	0.6	0.4	1.5	0.2	0.1	0.0	0.2	-0.7	-0.6	-0.1	1.0	0.3	0.3	0.6
Forced expiratory volume in 1-second (FEV1)	0.3	0.8	2.5	-1.1	-0.2	-1.6	-0.8	-0.4	-0.1	1.2	-0.9	-1.1	-1.0	-0.7	-1.3	-0.8	-1.6	0.1	-0.5	-0.7	-0.6
Loud music exposure frequency	0.3	0.4	1.5	-0.7	-1.1	0.1	-0.2	0.0	-0.7	-1.2	-1.1	0.7	0.3	0.8	0.5	0.3	-0.4	-0.4	0.1	-0.1	0.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.7	0.4	-0.7	1.4	-0.5	-1.6	0.8	0.4	0.7	-0.2	0.1	0.2	0.3	0.8	0.6	-0.4	-0.1	0.7	-0.4
Number of children fathered	0.3	0.3	1.4	-1.0	-0.6	-0.4	0.4	0.6	-0.9	-1.2	-1.0	0.1	0.2	0.6	0.1	-0.5	-0.4	-0.2	-0.0	-0.3	0.3
Arm predicted mass (right)	0.3	1.7	5.1	1.7	2.1	1.5	0.9	0.7	1.7	1.9	2.0	1.1	0.1	0.1	0.6	0.9	0.4	2.2	0.2	0.9	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.7	0.8	0.5	0.8	-0.3	-0.5	0.2	-1.4	0.7	-0.5	0.5	0.8	1.0	-0.4	0.7	0.3	1.7	1.3	0.1
Qualifications: nursing, teaching	0.3	0.4	1.9	0.5	0.2	-0.7	-0.4	-0.4	1.1	-0.6	0.0	0.9	-0.9	-0.7	-0.4	1.4	-0.1	-0.1	-0.9	-0.5	-0.0
Medication for cholesterol	0.3	0.5	1.5	-0.0	-0.9	-0.0	-0.6	-1.2	0.2	0.6	-0.1	-1.2	-0.6	-0.7	-1.1	-0.6	-0.6	0.3	-0.2	-0.1	-0.9
Guilty feelings	0.3	0.4	1.8	-0.1	-1.3	-0.8	-0.4	-1.1	0.2	1.1	-0.5	-0.3	-0.4	-0.9	-0.4	-0.0	-0.8	-0.1	-0.3	-0.1	-0.6
Eye problems/disorders: Glaucoma	0.3	0.3	2.7	0.1	0.1	-0.1	-0.6	-0.0	-0.7	-0.2	-0.1	-1.0	0.2	0.4	0.3	-1.6	0.3	-0.2	0.9	0.6	-0.1
Irritability	0.3	0.5	1.3	-0.1	0.8	0.1	-0.1	0.7	1.1	0.9	-0.1	0.6	0.6	1.0	0.6	0.1	0.2	0.8	0.8	1.1	0.7
Risk taking	0.3	0.5	1.8	0.5	-0.8	-0.1	-0.3	-1.0	0.3	-1.1	-0.2	0.5	0.5	-0.7	1.4	0.2	-0.4	0.3	1.3	0.8	-0.1
Bipolar Disorder or Schizophrenia	0.2	0.6	1.9	-1.3	-0.3	0.5	-0.9	0.4	-0.8	0.3	-1.4	-0.8	-0.4	0.3	-0.7	-1.3	-0.6	-0.1	-0.7	-0.7	-0.3
Neuroticism (Nagel 2018)	0.2	0.4	1.8	-1.4	-1.2	0.0	-0.4	-0.4	0.3	0.4	-1.0	-0.4	0.0	0.1	-0.0	-0.6	-0.4	-0.9	-0.5	-0.1	-0.4
Worry (Nagel 2018)	0.2	0.5	1.5	-1.0	-1.0	0.5	-0.1	-0.5	1.0	1.2	-0.3	-0.6	-0.2	0.4	-0.1	-0.5	-0.1	-0.2	-1.0	-0.7	-0.9
Irritable Bowel Disease (IBD)	0.2	0.5	1.6	0.4	0.0	0.0	0.1	-0.0	-0.5	-0.8	0.1	0.8	1.0	0.7	0.9	0.5	0.5	0.3	0.9	1.0	1.3
Crohns Disease (2012)	0.2	0.3	1.8	0.1	-0.0	0.6	-0.4	0.4	-1.4	-0.5	-0.2	-0.1	0.6	0.6	0.3	-0.2	0.4	-0.6	-0.5	-0.7	0.3
Ulcerative Colitis	0.2	0.3	1.1	-0.2	-1.1	-0.7	-0.9	-0.8	0.3	-0.5	-0.6	-0.4	-0.7	-0.2	-0.5	0.4	-0.5	-0.8	0.2	0.2	-0.3
Blood Red Count	0.2	2.0	11.6	-1.6	-0.4	1.9	-0.2	0.7	-1.9	1.8	-1.1	-1.6	-0.4	0.1	-1.6	-3.4	-1.1	0.6	-1.0	-0.9	0.4
Heel T-Score	0.2	1.7	4.8	1.1	-0.4	1.9	0.7	-0.2	0.8	-0.1	1.2	0.4	2.1	1.6	1.6	-0.6	1.6	2.2	0.9	1.4	1.6
Allergy or Eczema	0.2	0.6	1.8	-0.9	0.5	0.7	1.1	1.2	-0.6	-1.3	-1.0	-0.3	0.1	0.9	-0.3	-1.4	0.4	-1.0	0.1	0.1	0.5
Neuroticism	0.2	0.4	1.4	-1.2	-0.8	-0.3	-0.9	-0.0	0.2	-0.9	-0.9	-0.3	0.7	0.6	0.5	-0.4	-0.2	-0.8	-0.6	-0.3	-0.1
Hand grip strength (left)	0.2	0.5	2.4	-0.5	-1.2	-0.4	-1.5	-1.1	0.6	-0.5	-1.0	-0.1	-0.7	0.1	-0.2	0.6	-0.8	-0.2	-0.3	-0.1	-0.4
Sitting height	0.2	1.7	7.0	1.6	1.9	0.2	0.1	-0.6	2.6	1.5	2.0	0.5	0.6	0.2	0.2	1.0	0.4	2.3	0.6	1.6	0.5
Past tobacco smoking	0.2	0.3	0.8	0.4	0.6	0.7	0.1	-0.4	0.4	-0.1	0.6	-0.7	0.7	0.5	-0.0	-0.9	-0.1	0.8	0.5	0.8	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	-0.6	-0.4	0.8	-0.3	0.0	-0.3	-0.6	-0.3	0.4	0.7	0.4	0.6	1.0	-0.2	-0.7	0.3	0.1	0.4
Had menopause	0.2	0.2	2.0	-0.0	0.3	-1.4	0.3	0.2	0.0	0.4	0.3	0.2	-0.0	-0.1	0.4	0.6	0.5	-0.1	-0.4	-0.2	0.2
Neuroticism score	0.2	0.4	1.4	-1.2	-0.5	0.0	-0.2	0.1	0.0	0.7	-0.9	-0.5	-0.3	-0.1	-0.3	-0.7	-1.0	-0.3	-1.2	-0.9	-0.6
Arm fat percentage (right)	0.2	0.9	7.0	1.2	0.5	0.0	0.6	1.0	-0.5	2.7	0.9	1.3	-0.3	0.0	0.2	1.2	0.5	1.3	-0.0	-0.0	1.0
Alcohol intake versus 10 years previously	0.2	0.3	1.2	-1.1	-0.1	-0.8	0.3	0.5	-0.6	-0.1	-0.8	0.3	0.5	-0.2	0.0	-0.1	-0.7	-0.6	-0.9	-0.7	0.0
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.9	-0.2	-0.6	-0.2	-1.1	-1.4	1.2	-0.2	-0.4	0.1	-0.6	-0.0	-0.4	1.1	-0.2	-0.8	-0.1	0.4	-0.4
Tense / ‘highly strung’	0.2	0.3	1.6	-0.8	0.5	0.7	0.6	0.3	1.3	0.8	0.1	0.6	-0.2	-0.2	-0.0	0.7	0.0	0.2	-0.8	-0.2	0.1
Hair/balding pattern: Pattern 4	0.2	0.6	1.9	-0.8	-0.8	-0.0	-0.9	-0.6	0.0	0.1	-0.9	0.2	-0.8	-0.9	-0.5	0.8	-1.4	-0.1	-1.2	-1.3	-0.6
Leg fat percentage (right)	0.2	0.6	4.3	1.0	0.0	0.7	0.3	0.3	-0.5	2.1	0.8	0.8	-0.1	-0.3	0.4	0.8	-0.0	1.0	0.6	0.3	0.5
Whole body fat mass	0.2	0.8	6.2	1.1	0.7	0.4	0.4	0.7	-0.1	2.5	1.0	1.0	-0.4	-0.2	0.0	0.9	0.2	1.6	0.0	0.2	0.9
Leg fat mass (right)	0.2	0.7	5.0	1.2	0.3	0.5	0.4	0.3	-0.1	2.2	1.0	0.9	-0.2	-0.1	0.4	0.8	0.2	1.5	0.4	0.4	0.6
Arm fat percentage (left)	0.2	0.8	7.8	1.1	0.3	-0.0	0.4	0.7	-0.4	2.8	0.9	0.9	-0.4	-0.2	-0.1	1.0	0.4	1.2	-0.1	-0.1	0.8
Loneliness, isolation	0.2	0.2	1.0	-0.4	-0.2	-0.2	0.0	0.5	0.4	1.0	-0.3	0.7	0.1	0.4	0.6	0.7	-0.5	0.8	-0.3	-0.4	0.1
Friendships satisfaction	0.2	0.2	1.2	-0.1	1.1	-0.0	0.4	0.7	0.3	0.7	0.0	0.3	-0.7	0.1	-0.8	0.1	0.1	0.2	-0.3	-0.2	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.8	0.3	-0.1	-0.1	0.3	-0.1	-0.4	-0.7	0.1	0.8	0.2	0.7	0.5	0.4	0.9	0.3	0.5	0.5	0.8
Breast cancer (self-reported)	0.2	0.2	0.7	-0.0	0.4	0.8	0.7	0.6	-0.8	-0.4	0.5	-0.3	0.3	-0.2	0.7	0.1	0.0	-0.4	-0.4	-0.5	-0.5
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	0.1	-0.8	-0.1	-0.0	-1.0	0.4	0.1	-0.2	0.1	-0.6	-0.6	-0.2	0.1	-0.3	-0.0	-0.4	0.0	-0.8
Average weekly champagne plus white wine intake	0.2	0.3	1.5	0.0	-0.6	-1.1	-0.7	-0.6	-0.1	-0.2	-0.4	0.1	-0.6	-0.9	-1.2	-0.4	-0.7	-0.3	0.3	0.1	-0.4
Miserableness	0.2	0.4	2.0	0.4	0.3	1.2	0.5	0.4	0.3	0.1	0.6	0.3	0.3	0.3	1.4	0.8	0.1	0.3	-0.6	-0.6	-0.4
Medication: Bendroflumethiazide	0.2	0.3	1.0	0.2	0.2	-1.0	0.3	-0.9	0.9	0.6	1.0	-0.0	-0.0	-0.8	0.2	0.8	-0.0	-0.1	0.3	-0.1	-0.8
Ever smoked	0.2	0.3	1.1	-0.3	0.0	-0.1	0.3	0.7	-0.1	0.4	-0.3	0.7	-0.7	-1.0	-0.2	0.6	-0.2	-0.3	-1.1	-0.8	-0.0
Diastolic blood pressure, automated reading	0.2	0.6	4.4	0.0	0.3	0.1	-0.4	-0.6	-2.1	-1.1	0.2	-0.7	0.4	0.3	-0.5	-1.1	1.2	-0.5	-0.2	-0.2	0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.8	0.3	0.6	-0.2	0.4	0.3	-0.5	-0.1	0.1	0.8	0.5	0.6	0.0	0.5	0.3	0.6	0.5	0.2	0.9
Leg fat mass (left)	0.2	0.6	4.8	0.9	0.4	0.4	0.3	0.5	-0.1	2.2	0.8	0.9	-0.3	-0.1	0.2	0.7	0.2	1.3	0.2	0.3	0.7
Ulcerative Colitis (UC)	0.1	0.2	1.0	-0.2	-0.8	0.2	-0.8	-1.0	0.3	0.1	-0.2	-0.2	-0.4	-0.4	0.1	0.7	-0.5	-0.5	0.1	0.4	-0.2
Height	0.1	2.5	14.5	1.4	1.8	0.8	0.1	-1.0	3.8	1.7	2.0	0.1	-1.4	-1.7	-0.9	-0.4	-1.0	2.9	-0.5	0.8	-1.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	1.4	-0.0	-0.3	1.2	-0.6	-0.2	-0.6	0.2	-0.2	0.4	-0.1	-0.0	-0.4	0.8	-0.1	-0.1	-0.4	-0.5	0.2
Lung FVC	0.1	0.7	3.5	-0.1	0.0	-0.8	-0.6	0.4	1.5	1.9	-0.3	0.3	0.2	0.9	0.4	0.3	0.4	0.9	1.3	1.1	1.1
Tanning	0.1	0.7	2.8	0.3	-1.1	-0.4	-1.0	-1.6	-0.4	0.6	0.3	-0.7	-0.5	-1.7	-0.3	0.1	-0.9	-0.0	-0.0	-0.9	-1.4
Trunk fat percentage	0.1	0.4	3.7	0.0	-0.3	-0.4	-0.3	0.4	-0.8	1.9	0.0	0.3	-0.8	-0.6	-0.6	0.7	-0.4	0.4	-0.2	-0.5	0.5
Trunk fat mass	0.1	0.6	4.9	0.8	0.4	0.1	0.1	0.5	-0.1	2.2	0.8	0.8	-0.5	-0.4	-0.1	0.9	0.0	1.2	-0.1	0.1	0.7
Forced vital capacity (FVC)	0.1	0.3	1.3	-0.0	-0.2	-1.1	-0.4	-0.6	0.2	0.8	0.1	-0.7	0.2	0.3	0.4	-0.7	-0.5	0.6	0.8	0.6	0.0
Diabetes (self-reported)	0.1	0.1	0.8	0.5	0.1	-0.5	-0.4	-0.2	-0.1	0.4	-0.0	0.7	-0.2	-0.2	-0.1	0.9	0.4	-0.2	0.2	0.0	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	2.0	0.0	0.3	0.2	-0.2	-0.2	0.4	1.2	0.2	-0.1	0.4	0.5	-0.2	0.2	-0.4	1.4	1.1	0.8	0.9
Standing height	0.1	1.1	6.0	1.1	1.4	-0.2	-0.1	-0.6	2.4	0.1	1.5	0.5	0.1	-0.2	0.4	0.6	-0.2	2.1	0.5	1.4	0.3
Body fat percentage	0.1	0.4	4.2	0.4	-0.2	-0.1	-0.1	0.4	-0.8	2.0	0.3	0.6	-0.6	-0.5	-0.2	0.8	-0.1	0.5	0.1	-0.2	0.6
Comparative body size at age 10	0.1	0.2	1.4	-0.4	0.2	-1.2	-0.2	-0.1	0.3	0.5	-0.4	0.6	-0.0	-0.0	-0.3	1.1	-0.0	0.2	-0.2	-0.2	0.3
Medication: Omeprazole	0.1	0.1	0.6	-0.1	0.3	-0.4	-0.0	0.1	-0.1	0.1	-0.2	0.6	-0.0	0.0	-0.1	0.7	-0.4	0.5	0.3	-0.3	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	-0.3	0.4	-0.2	0.1	0.4	-0.7	-0.4	-0.1	0.1	0.6	0.3	0.4	-0.2	0.7	-0.3	-0.5	-0.1	0.5
Comparative height size at age 10	0.1	0.4	1.4	0.3	1.0	-0.6	0.3	0.9	0.7	1.2	0.4	0.6	-0.3	-0.1	-0.2	0.0	-0.2	1.2	-0.3	0.4	0.7
Diabetes diagnosed by doctor	0.1	0.2	0.8	-0.0	-0.4	-0.1	-0.7	-0.0	-0.8	-0.3	-0.7	0.4	-0.1	-0.1	-0.1	0.4	0.2	-0.9	-0.0	-0.3	0.3
Leg fat percentage (left)	0.1	0.3	3.4	0.4	-0.1	0.5	0.2	0.5	-0.6	1.9	0.2	0.7	-0.4	-0.4	-0.0	0.6	-0.2	0.5	0.3	-0.0	0.5
Hair Pigment	0.0	1.2	4.1	1.2	1.0	-0.4	0.2	-0.5	2.0	2.0	1.5	0.7	0.4	-0.8	0.8	1.2	0.6	1.2	1.0	1.6	0.2

Hub : Genes

DENND3

Models

Trait associations