Hub : Genes

NCBP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Liver 0.405 0.142 0.0037 -0.010 NA 0.029 NA 0.025 0.790 NA 0.054 NA 0.068
2 TCGA Pheochromocytoma and Paraganglioma 0.162 0.096 0.0021 0.022 0.064 0.032 NA 0.036 0.045 0.0015 0.020 NA 0.014

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.5 0.9 1.7 1.3 -0.0
Bipolar Disorder or Schizophrenia 0.3 0.7 1.5 1.2 0.1
Depressed Affect (Nagel 2018) 0.7 1.4 2.8 -0.0 -1.7
Depression (Nagel 2018) 0.2 0.3 0.5 -0.7 -0.3
Intelligence (Savage-Jansen 2018) 0.2 0.5 0.5 0.7 -0.7
Neuroticism (Nagel 2018) 1.5 3.6 5.0 -1.5 -2.2
Schizophrenia (2018) 0.1 0.1 0.2 0.5 0.2
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 -0.4 -0.3
Worry (Nagel 2018) 1.2 2.5 4.0 -2.0 -1.0
Alzheimer’s Disease (in mother) 0.2 0.2 0.3 -0.6 0.2
Alzheimer’s Disease (in father) 0.2 0.2 0.3 0.4 0.5
Alzheimer’s Disease (including proxy) 0.0 0.0 0.0 0.1 0.1
Crohns Disease (2017) 1.1 2.4 3.5 1.1 -1.9
Irritable Bowel Disease (IBD) 0.9 2.1 2.4 1.4 -1.6
Ulcerative Colitis (UC) 0.3 0.6 0.8 0.9 -0.6
Major Depression (MDD) 0.7 0.8 1.0 -1.0 -0.8
Reaction Time 0.8 1.6 1.9 1.1 -1.4
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.3 -0.4 -1.5
Breast Cancer 0.7 1.7 3.4 1.8 0.2
Ovarian Cancer 0.2 0.2 0.3 -0.5 0.4
Prostate Cancer 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.5 0.7 1.0 0.6 -1.0
Bipolar Disorder (2011) 1.0 1.0 1.1 -1.0 0.9
Body Mass Index (BMI) (2010) 0.8 1.0 1.9 1.4 -0.4
Coronary Artery Disease (CAD) 0.6 0.7 1.2 -0.5 -1.1
Crohns Disease (2012) 0.8 1.2 2.4 0.1 -1.6
Mean Putamen Volume 1.2 1.3 2.4 1.6 -0.5
Fasting Glucose 1.3 1.6 2.2 -1.0 -1.5
HbA1C 1.4 1.6 3.2 -1.8 -0.1
HDL Cholesterol 0.7 1.2 2.4 1.6 0.1
LDL Cholesterol 1.4 2.2 4.4 -2.1 -0.2
Lupus 2.6 4.0 5.4 2.3 -1.6
Neuroticism (2016) 0.8 1.1 2.2 -0.2 -1.5
Primary Biliary Cirrhosis 0.8 1.2 2.3 0.2 -1.5
Rheumatoid Arthritis 0.1 0.1 0.2 -0.3 -0.5
Schizophrenia (2014) 0.1 0.2 0.3 0.3 0.6
Triglycerides 0.5 0.8 1.1 -1.1 0.6
Type 2 Diabetes (T2D) (2012) 1.5 1.8 1.9 1.3 1.4
Ulcerative Colitis 0.1 0.1 0.1 -0.2 -0.4
Blood Eosinophil Count 0.1 0.4 0.8 0.2 -0.9
Blood Platelet Count 0.2 2.6 4.0 -2.0 1.1
Blood Red Count 0.0 0.1 0.2 0.1 -0.4
Blood White Count 0.7 4.9 5.8 -2.0 2.4
Heel T-Score 0.5 4.0 6.1 -1.4 2.5
BMI 0.5 3.0 5.3 2.3 -0.8
Height 0.8 15.0 29.2 0.9 -5.4
Waist Hip Ratio (WHR) 0.0 0.0 0.1 0.1 -0.3
Systolic Blood Pressure 0.8 4.2 8.5 -2.9 -0.0
Smoking Status 0.2 0.5 1.0 -0.2 -1.0
Allergy or Eczema 0.5 1.4 2.7 -0.1 1.6
Cardiovascular Disease 0.2 0.6 1.2 -1.1 -0.3
Hypothyroidism (self reported) 9.7 22.2 44.4 -0.3 6.7
Respiratory disease 0.3 0.7 1.3 0.2 1.1
Type 2 Diabetes (T2D) (2018) 1.5 2.8 4.9 -2.2 -0.8
Lung FEV1/FVC ratio 3.3 16.7 28.7 -2.2 -5.4
Lung FVC 0.4 2.2 3.5 1.0 1.9
Neuroticism 1.6 3.8 4.0 -1.9 -2.0
Chronotype (morning person) 1.0 2.2 2.6 1.4 -1.6
Hair Pigment 0.2 7.0 12.9 1.1 3.6
Tanning 0.0 0.1 0.1 -0.3 -0.3
Hand grip strength (left) 0.0 0.0 0.1 -0.2 0.1
Number of treatments/medications taken 0.0 0.0 0.1 0.1 -0.2
Average weekly spirits intake 0.6 0.7 1.2 -0.5 -1.1
Sensitivity / hurt feelings 0.7 1.2 1.3 -1.1 -1.0
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.4 -0.4 -0.6
Hearing difficulty/problems: Yes 0.6 0.8 1.5 1.2 -0.4
Relative age of first facial hair 0.0 0.0 0.0 0.1 0.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 1.1 -0.1 -1.1
Ever used hormone-replacement therapy (HRT) 0.5 0.6 0.8 0.9 0.6
Ever had hysterectomy (womb removed) 0.2 0.2 0.4 -0.6 -0.2
Systolic blood pressure, automated reading 0.7 1.9 3.8 -1.9 -0.3
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 0.5 -0.1
Angina 0.2 0.2 0.2 -0.5 0.5
Medication for hormone replacement therapy 0.3 0.4 0.7 0.8 -0.2
Vitamin and mineral supplements 2.6 3.5 4.5 1.6 2.1
Supplements: Zinc 0.4 0.5 0.8 0.4 0.9
Medication: Co-codamol 0.6 0.7 1.3 1.1 0.3
Medication: Metformin 0.9 1.3 1.4 -1.2 -1.1
Diabetes (father) 2.5 3.1 5.5 -2.3 0.9
Diabetes (mother) 1.5 1.9 2.9 -1.7 -1.0
Severe depression (siblings) 0.2 0.3 0.3 0.5 0.6
Pack years adult smoking proportion 0.2 0.4 0.5 -0.5 0.7
Impedance of leg (right) 0.8 3.8 7.7 -0.1 2.8
Leg fat-free mass (left) 0.6 3.0 5.2 0.9 -2.3
Trunk fat percentage 0.3 1.3 2.5 1.6 0.1
Hand grip strength (right) 0.1 0.3 0.4 -0.4 0.6
Townsend deprivation index at recruitment 0.2 0.2 0.3 0.4 0.5
Current tobacco smoking 0.2 0.4 0.7 -0.2 -0.8
Average weekly fortified wine intake 0.6 0.7 1.1 1.0 0.5
Maternal smoking around birth 1.2 1.7 2.9 1.7 -0.7
Fed-up feelings 0.7 1.3 2.4 1.6 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.0 0.1 0.0
Relative age voice broke 0.0 0.1 0.1 -0.3 0.1
Taking other prescription medications 0.2 0.2 0.5 -0.1 0.7
Age when periods started (menarche) 1.4 3.5 4.5 2.1 1.6
Bilateral oophorectomy (both ovaries removed) 1.8 2.1 2.2 1.5 -1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.4 -0.6 0.1
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.8 -0.9 -0.2
Qualifications: CSEs or equivalent 0.9 1.1 2.1 1.5 -0.4
Serious illness, injury or assault to yourself 1.0 1.2 1.3 1.0 -1.1
High blood pressure 0.7 2.1 2.7 -1.2 -1.6
Hayfever, allergic rhinitis or eczema 0.6 1.3 2.1 0.6 1.5
Multivitamins +/- minerals 1.3 1.6 3.2 -0.1 -1.8
Stomach or abdominal pain in last month 0.8 0.9 1.2 1.1 -0.8
Supplements: Glucosamine 0.3 0.4 0.8 0.9 -0.1
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 1.9 -1.4 0.6
Medication: Atenolol 4.0 5.0 10.0 -3.2 0.1
Medication: Levothyroxine sodium 8.6 14.5 28.7 0.5 5.4
Sitting height 0.3 2.1 2.8 1.2 -1.7
Chronic bronchitis/emphysema (father) 1.1 1.3 2.6 1.6 -0.1
High blood pressure (mother) 1.7 2.3 4.0 -0.8 -2.0
Body mass index (BMI) 0.2 0.7 1.4 1.2 0.1
Impedance of leg (left) 0.7 3.5 6.7 0.5 2.6
Leg predicted mass (left) 0.5 2.9 5.0 0.8 -2.2
Trunk fat mass 0.3 1.3 2.4 1.6 -0.3
Waist circumference 0.1 0.4 0.8 0.9 0.3
Number of incorrect matches in round 0.7 1.1 2.0 -1.4 0.5
Past tobacco smoking 0.5 0.9 1.1 0.9 1.1
Alcohol usually taken with meals 0.9 1.4 1.7 1.3 -1.1
Nervous feelings 0.5 1.0 1.8 -0.3 -1.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.6 -0.1 0.8
Hearing difficulty/problems with background noise 1.0 1.6 2.9 0.6 -1.7
Hair/balding pattern: Pattern 2 0.5 0.6 1.2 -1.1 0.0
Had menopause 2.7 3.4 6.0 0.8 -2.5
Had other major operations 1.3 1.6 3.2 -0.1 1.8
Forced vital capacity (FVC) 0.2 0.9 1.3 1.1 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.1 -1.4 0.2
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 1.8 0.6 -1.4
Qualifications: None of the above 0.0 0.0 0.0 -0.0 -0.2
Financial difficulties in last 2 years 0.9 1.2 1.3 -1.1 -1.2
Mouth/teeth dental problems 0.9 1.4 2.5 0.5 1.6
Heart attack 0.5 0.6 0.9 0.9 0.5
Allergy 0.9 2.0 2.4 -1.2 -1.6
Pain all over the body in last month 0.2 0.3 0.3 -0.4 -0.6
Diabetes (self-reported) 1.1 1.8 3.5 -1.9 0.0
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.6 0.8 0.5
Medication: Ramipril 2.5 3.3 5.8 0.8 2.4
Medication: Simvastatin 0.2 0.2 0.4 -0.3 -0.6
Fluid intelligence score 1.5 3.0 4.5 1.2 -2.1
Illnesses of siblings 0.5 0.7 0.8 -0.9 0.8
Neuroticism score 0.9 1.8 2.4 -1.6 -1.1
Weight 0.4 1.8 2.2 1.5 -1.1
Impedance of arm (right) 0.0 0.0 0.1 -0.3 0.0
Arm fat percentage (right) 0.2 0.8 1.5 1.2 0.3
Trunk fat-free mass 0.4 2.4 4.7 0.4 -2.2
Hip circumference 0.2 0.7 1.3 1.1 0.2
Time employed in main current job 0.0 0.0 0.0 -0.1 0.2
Alcohol intake versus 10 years previously 0.7 1.0 1.3 1.2 -0.8
Father’s age at death 0.3 0.4 0.6 -0.8 0.4
Worrier / anxious feelings 0.6 1.2 1.4 -0.9 -1.2
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 2.4 -0.2 1.5
Falls in the last year 0.0 0.0 0.0 0.1 0.2
Hair/balding pattern: Pattern 3 0.2 0.3 0.4 0.7 0.3
Number of live births 1.3 1.8 2.6 -1.0 1.6
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 3.5 0.5 -1.9
Pulse rate 0.5 0.9 1.4 1.2 -0.6
Happiness 1.2 1.5 2.1 -1.0 -1.4
Noisy workplace 3.1 3.9 4.1 -2.0 1.9
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.2 -1.1 0.0
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 1.6 0.6 -1.3
Mouth/teeth dental problems: Dentures 1.0 1.7 3.3 -0.3 -1.8
Asthma 0.8 1.5 2.3 1.5 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.6 0.8 -0.4
Medication: Cholesterol lowering 0.2 0.4 0.7 -0.0 -0.9
Depression (self-reported) 2.8 3.4 6.7 -2.6 0.1
Medication: Lansoprazole 1.5 1.7 3.1 0.5 -1.8
Prospective memory result 0.3 0.4 0.7 0.9 -0.2
Lung cancer (father) 0.6 0.7 0.8 0.9 0.7
Illnesses of mother 0.9 1.1 1.6 0.8 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 3.4 0.4 -1.8
Pulse wave Arterial Stiffness index 0.2 0.3 0.4 0.3 0.7
Impedance of arm (left) 0.0 0.2 0.3 -0.6 0.4
Arm fat mass (right) 0.3 1.2 1.9 1.4 -0.6
Trunk predicted mass 0.5 2.6 5.0 0.4 -2.2
Standing height 0.4 4.2 7.8 0.7 -2.8
Length of working week for main job 0.5 0.6 1.1 1.1 0.2
Exposure to tobacco smoke at home 1.7 1.9 3.5 -1.9 -0.4
Breastfed as a baby 1.6 2.0 3.6 -1.9 -0.6
Tense / ‘highly strung’ 1.7 2.8 5.5 -2.4 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 1.9 -1.4 0.6
Hair/balding pattern: Pattern 4 0.3 0.8 0.9 0.9 -0.9
Birth weight of first child 1.2 2.1 2.6 1.3 1.6
Peak expiratory flow (PEF) 0.3 0.7 0.9 0.6 -0.9
Pulse wave reflection index 0.7 0.8 1.6 -1.3 0.1
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.6 0.8 -0.4
Loud music exposure frequency 1.7 1.9 2.4 -1.2 1.5
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.4 0.4 1.2
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.4 -0.1 -1.2
Blood clot in the leg (DVT) 0.4 0.5 0.9 0.3 1.0
Medication: Paracetamol 0.2 0.4 0.8 -0.9 -0.1
Headache pain in last month 0.0 0.0 0.1 0.3 -0.0
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.1 0.7 1.0
Glaucoma (self-reported) 0.8 1.0 1.3 -0.8 1.1
Gout (self-reported) 0.3 0.4 0.6 0.8 -0.4
Hypothyroidism/myxoedema (self-reported) 10.3 20.0 39.3 -0.9 6.3
Medication: Amlodipine 0.2 0.3 0.5 0.7 0.3
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.6 0.6 0.8
Birth weight 0.2 0.5 1.0 -1.0 0.2
Chronic bronchitis/emphysema (mother) 1.0 1.2 2.3 0.4 1.5
High blood pressure (siblings) 1.7 2.4 2.6 1.5 -1.6
Forced vital capacity (FVC), Best measure 0.1 0.4 0.5 0.7 -0.6
Body fat percentage 0.5 1.8 3.0 1.7 0.8
Leg fat percentage (right) 0.9 3.2 5.1 1.1 2.3
Arm fat-free mass (right) 0.5 2.5 3.3 1.3 -1.8
Exposure to tobacco smoke outside home 0.0 0.0 0.0 -0.1 -0.2
Comparative body size at age 10 0.2 0.6 0.6 0.7 -0.8
Number of full brothers 1.2 1.5 2.9 1.7 -0.2
Worry too long after embarrassment 1.7 2.8 4.6 -2.1 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.0 0.1 0.2
Wheeze or whistling in the chest in last year 0.6 1.1 2.1 1.4 -0.3
Number of children fathered 1.1 1.2 1.9 0.7 1.4
Reason for reducing amount of alcohol drunk: Health precaution 2.6 3.0 5.4 -0.7 2.3
Age at first live birth 0.5 1.0 1.9 0.2 -1.4
Pulse wave peak to peak time 0.5 0.6 1.1 -0.2 -1.0
Health satisfaction 0.8 1.1 1.7 1.3 0.7
Shortness of breath walking on level ground 1.9 2.3 4.6 2.1 0.0
Qualifications: College or University degree 0.2 0.7 1.0 -1.0 0.7
Eye problems/disorders: None of the above 0.2 0.3 0.4 -0.4 -0.6
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.3 0.5 -0.2
Emphysema/chronic bronchitis 1.1 1.2 2.3 1.5 -0.2
Medication for pain relief, constipation, heartburn 1.7 2.8 5.5 2.4 -0.3
Neck or shoulder pain in last month 1.3 1.9 3.8 2.0 -0.1
Medication: Blood pressure 0.7 1.3 1.8 -0.9 -1.3
Angina (self-reported) 0.2 0.3 0.5 -0.7 0.4
Migraine (self-reported) 0.6 0.8 1.6 -1.3 -0.0
Medication: Ibuprofen 2.1 2.6 3.0 1.7 -1.4
Medication: Allopurinol 0.3 0.5 0.8 0.9 -0.3
Medication: Omeprazole 0.5 0.6 0.8 -0.6 -0.9
Medication: Seretide 50 evohaler 0.3 0.4 0.5 -0.4 0.7
Mean time to correctly identify matches 0.2 0.4 0.6 -0.4 -0.8
Heart disease (mother) 0.2 0.2 0.4 0.6 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.0 1.3 -0.9 1.1
Whole body fat mass 0.3 1.4 2.8 1.7 -0.3
Leg fat mass (right) 0.4 1.6 2.3 1.5 1.0
Arm predicted mass (right) 0.6 3.1 3.9 1.5 -2.0
Pulse rate, automated reading 0.7 2.3 2.9 1.7 -1.3
Alcohol intake frequency. 1.1 2.6 5.2 2.3 -0.2
Comparative height size at age 10 1.3 7.4 14.4 0.7 -3.8
Number of full sisters 3.7 4.5 8.4 -2.9 0.8
Suffer from ‘nerves’ 1.7 2.6 4.5 -2.1 -0.8
Overall health rating 0.6 1.4 1.6 1.3 1.0
Chest pain or discomfort 0.3 0.4 0.8 0.9 0.3
Had major operations 2.1 2.4 4.2 -0.8 2.1
Age at last live birth 0.1 0.2 0.3 0.0 -0.6
Family relationship satisfaction 0.1 0.1 0.1 -0.4 -0.2
Leg pain on walking 0.1 0.1 0.1 -0.4 0.0
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.0 0.0 0.2 0.1
Commuting to job workplace: Car/motor vehicle 0.9 1.1 2.1 -0.2 1.4
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.7 -0.1 0.8
Medication: Aspirin 0.6 0.8 1.5 -0.4 1.2
Supplements: Vitamin C 1.5 1.7 3.0 -0.7 -1.7
Knee pain experienced in last month 1.0 1.5 1.6 -1.2 -1.3
Hypertension (Self-reported) 0.7 2.1 2.6 -1.2 -1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 0.3 -0.4
Illnesses of father: Heart disease 0.9 1.2 1.8 1.3 0.8
Illnesses of siblings: Diabetes 0.1 0.1 0.3 0.5 0.1
Smoking status: Previous 0.1 0.2 0.4 -0.6 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 0.9 -0.6 -1.0
Whole body fat-free mass 0.6 3.2 5.7 0.8 -2.4
Leg fat-free mass (right) 0.8 4.4 7.5 1.2 -2.7
Arm fat percentage (left) 0.2 0.9 1.5 1.2 0.6
Average weekly red wine intake 0.2 0.2 0.4 0.6 0.3
Handedness (chirality/laterality): Left-handed 1.1 1.3 1.8 -0.9 -1.3
Mood swings 0.2 0.3 0.5 0.3 -0.7
Loneliness, isolation 0.1 0.1 0.1 0.3 -0.2
Long-standing illness, disability or infirmity 0.1 0.1 0.1 0.4 -0.4
Ever had bowel cancer screening 0.2 0.2 0.2 -0.5 -0.4
Diabetes diagnosed by doctor 1.1 1.7 3.5 -1.9 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.4 0.6 0.4
Friendships satisfaction 0.3 0.4 0.7 -0.8 -0.2
Qualifications: nursing, teaching 0.7 1.1 1.5 -1.2 0.9
Commuting to job workplace: Walk 0.3 0.3 0.5 0.7 -0.4
Eye problems/disorders: Cataract 0.2 0.2 0.4 0.4 0.6
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 1.3 0.8 1.1
Medication for cholesterol 0.0 0.0 0.0 0.2 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 -0.5 -0.2
Back pain experienced in last month 0.1 0.1 0.2 0.1 -0.5
Mineral and other dietary supplements 0.3 0.5 0.8 -0.4 0.9
Breast cancer (self-reported) 0.2 0.2 0.4 -0.6 0.1
Asthma (self-reported) 0.8 1.6 2.6 1.6 0.8
Osteoporosis (self-reported) 0.1 0.1 0.2 -0.2 -0.4
Osteoarthritis (self-reported) 0.1 0.1 0.2 -0.5 0.2
Medication: Aspirin 0.5 0.6 1.2 -0.2 1.1
Medication: Gliclazide 0.2 0.2 0.2 -0.5 -0.4
Illnesses of father: None of the above (group 1) 1.0 1.2 2.0 -0.7 -1.4
Smoking status: Current 0.5 0.7 1.3 -0.4 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.8 -1.3 0.2
Whole body water mass 0.6 3.2 5.6 0.9 -2.4
Leg predicted mass (right) 0.8 4.3 7.2 1.2 -2.7
Arm fat mass (left) 0.2 1.0 1.8 1.3 -0.5
Number of self-reported non-cancer illnesses 0.5 0.8 1.5 -0.4 1.2
Average weekly champagne plus white wine intake 0.8 1.1 2.0 0.5 -1.4
Miserableness 1.3 2.2 2.4 -1.5 -1.4
Guilty feelings 1.6 2.4 4.2 0.8 -2.1
Wears glasses or contact lenses 0.9 1.0 2.0 -0.3 1.4
Ever taken oral contraceptive pill 0.4 0.4 0.6 -0.4 0.8
Hearing aid user 5.2 5.9 8.8 3.0 1.7
Mother’s age at death 0.7 0.9 1.4 -0.6 1.2
Financial situation satisfaction 1.5 1.8 2.4 1.1 -1.6
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.3 0.6 0.2
Commuting to job workplace: Public transport 0.2 0.2 0.3 -0.1 -0.6
Eye problems/disorders: Glaucoma 0.5 0.5 1.0 -1.0 0.3
Medication: Blood pressure 0.8 1.4 1.5 -1.2 -1.2
Pain type(s) experienced in last month: Hip pain 1.1 1.4 1.6 1.1 -1.3
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.6 0.2 -1.3
High cholesterol (Self-reported) 0.5 0.8 1.5 0.4 1.2
Medication: Bendroflumethiazide 0.3 0.4 0.8 0.3 -0.9
Medication: Paracetamol 0.2 0.3 0.5 0.3 -0.7
Medication: Lisinopril 4.8 6.2 12.3 0.3 -3.5
Medication: Atorvastatin 0.2 0.3 0.6 -0.2 0.8
Illnesses of father: High blood pressure 0.3 0.4 0.4 -0.6 -0.6
Alcohol drinker status: Never 3.3 4.0 7.7 2.8 0.6
Ever smoked 0.3 0.6 0.8 -0.9 -0.6
Basal metabolic rate 0.5 2.8 4.7 1.0 -2.2
Leg fat percentage (left) 0.8 3.0 4.1 1.4 2.0
Arm fat-free mass (left) 0.6 2.8 4.0 1.3 -2.0
Number of operations (self-reported) 0.8 1.3 2.5 0.1 1.6
Average weekly beer plus cider intake 1.6 2.3 4.6 -0.3 2.1
Irritability 0.1 0.2 0.3 -0.6 0.3
Risk taking 1.0 1.5 3.0 -1.7 -0.1
Ever had prostate specific antigen (PSA) test 1.6 1.9 3.4 -0.6 -1.8
Fractured/broken bones in last 5 years 0.2 0.3 0.5 0.4 0.7
Age started oral contraceptive pill 0.3 0.4 0.8 0.9 0.1
Diastolic blood pressure, automated reading 0.2 0.6 0.8 0.6 0.9
Ever depressed for a whole week 0.7 0.8 1.6 -0.3 -1.3
Unable to work because of sickness or disability 0.5 0.7 1.3 -1.1 -0.1
Commuting to job workplace: Cycle 0.4 0.5 0.7 0.8 -0.5
Myopia 2.6 3.8 4.2 -2.1 -1.8
Vascular/heart problems diagnosed by doctor 0.5 1.4 1.7 1.3 1.1
Cholesterol lowering medication 0.1 0.2 0.2 -0.3 0.5
Medication: Omeprazole (e.g. Zanprol) 1.7 2.0 3.5 -0.8 -1.9
Pain experienced in last month 1.1 1.8 3.5 -0.4 1.9
Supplements: Calcium 0.5 0.5 0.9 -0.9 0.4
Basal cell carcinoma (self-reported) 0.7 0.8 1.1 -1.0 0.8
Heart attack/myocardial infarction (self-reported) 0.5 0.6 0.9 0.9 0.6
Deep venous thrombosis (DVT) (self-reported) 0.7 0.8 1.6 -0.3 1.3
Heart disease (siblings) 0.1 0.1 0.2 0.5 -0.1
Alcohol drinker status: Previous 1.1 1.2 2.3 0.3 -1.5
Pack years of smoking 0.4 0.7 0.7 -0.8 0.8
Impedance of whole body 0.2 0.9 1.8 0.3 1.3
Leg fat mass (left) 0.4 1.6 2.7 1.6 0.7
Arm predicted mass (left) 0.7 3.3 4.5 1.5 -2.1