TWAS hub - TSTD2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1210	0.0510	3.4e-03	0.003	NA	0.018	NA	0.021	2.1e-01	NA	3.7e-02	NA	2.8e-02
2	GTEx	Adrenal Gland	0.2431	0.0833	2.3e-03	0.109	NA	0.032	NA	0.074	9.8e-05	NA	2.5e-02	NA	1.2e-03
3	GTEx	Artery Tibial	0.0803	0.0295	1.1e-03	0.036	NA	0.042	NA	0.054	7.9e-04	NA	2.9e-04	NA	4.3e-05
4	GTEx	Esophagus Gastroesophageal Junction	0.2150	0.0690	4.0e-04	0.037	NA	0.067	NA	0.055	1.8e-02	NA	2.0e-03	NA	4.8e-03
5	GTEx	Heart Left Ventricle	0.2142	0.0660	1.3e-05	0.164	NA	0.135	NA	0.148	4.4e-09	NA	1.2e-07	NA	2.7e-08
6	GTEx	Nerve Tibial	0.1000	0.0394	1.6e-03	-0.004	NA	0.001	NA	-0.003	9.8e-01	NA	2.6e-01	NA	5.9e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Hypothyroidism (self reported)	12.3	28.3	116.6	-3.1	-4.1	-2.6	-10.8	0.9	-4.4
Medication: Lisinopril	9.9	12.9	26.8	5.2	4.3	4.4	0.6	3.0	1.9
Hypothyroidism/myxoedema (self-reported)	9.6	18.7	76.0	-2.6	-3.5	-2.0	-8.7	1.3	-3.3
Medication: Levothyroxine sodium	8.8	15.0	57.2	-2.7	-3.4	-2.3	-7.6	0.3	-2.9
Depression (self-reported)	5.1	6.2	10.9	1.5	2.1	2.9	2.5	3.3	2.1
Lung FEV1/FVC ratio	4.8	24.4	43.3	6.6	6.3	6.1	2.7	3.2	3.0
Diabetes (mother)	4.4	5.6	8.0	2.8	2.2	2.7	0.5	2.4	2.8
Birth weight of first child	4.2	7.6	11.7	-3.4	-3.1	-3.2	-1.2	-2.9	-2.0
Medication: Blood pressure	4.2	7.4	10.5	3.2	2.9	3.2	0.2	2.7	2.7
High blood pressure	3.7	10.2	14.7	3.8	3.8	3.8	1.2	3.1	2.6
Medication: Simvastatin	3.6	5.3	8.4	2.5	2.7	2.9	0.9	2.7	1.4
Fasting Glucose	3.5	4.2	7.5	2.7	2.1	2.3	0.5	2.4	1.3
Falls in the last year	3.5	4.7	6.2	-0.3	-2.5	-2.5	-2.2	-2.3	-2.4
Happiness	3.4	4.1	9.0	1.3	3.0	2.5	2.1	1.5	0.9
Mouth/teeth dental problems: Mouth ulcers	3.4	5.4	9.1	-1.2	-2.5	-2.7	-3.0	-2.4	-1.8
Loud music exposure frequency	3.3	3.6	7.4	-2.7	-2.2	-2.1	0.1	-1.6	-1.5
Medication for cholesterol, blood pressure or diabetes	3.3	5.5	7.6	-2.8	-2.2	-2.8	-0.2	-2.5	-2.6
Hypertension (Self-reported)	3.2	9.0	13.0	3.6	3.6	3.6	1.0	2.8	2.5
Vascular/heart problems diagnosed by doctor	2.9	7.9	11.2	-3.4	-3.1	-3.2	-1.0	-2.9	-2.7
Eye problems/disorders: None of the above	2.8	3.2	5.4	1.3	1.7	2.1	1.9	2.3	1.2
High blood pressure (mother)	2.7	3.7	6.7	2.4	2.6	2.6	0.8	1.5	0.7
Prospective memory result	2.7	3.3	7.6	0.3	2.8	2.4	1.7	1.6	0.9
Medication: Gliclazide	2.3	2.5	3.9	1.5	1.9	2.0	0.9	1.6	1.6
Systolic blood pressure, automated reading	2.2	6.3	9.1	2.4	2.6	3.0	1.0	3.0	2.5
Family relationship satisfaction	2.2	2.7	5.6	0.7	2.4	2.0	1.5	1.8	0.9
Smoking status: Current	2.1	3.3	6.3	0.7	2.5	2.3	2.3	1.1	1.1
Financial situation satisfaction	2.1	2.6	5.9	0.5	2.3	1.7	2.4	0.6	0.9
Medication: Blood pressure	2.1	4.1	5.7	2.2	2.4	2.1	1.7	1.7	2.0
Type 2 Diabetes (T2D) (2018)	2.0	3.7	6.4	2.5	1.5	2.2	1.1	2.3	1.5
Medication: Atenolol	2.0	2.5	5.0	1.5	0.9	1.6	0.6	1.9	2.2
Allergy or Eczema	1.9	5.0	8.0	-1.5	-2.7	-2.8	-2.0	-1.7	-2.4
Hayfever, allergic rhinitis or eczema	1.9	4.2	6.2	-1.4	-2.2	-2.5	-1.8	-1.7	-2.4
Reaction Time	1.8	3.4	5.3	1.7	2.2	2.3	1.0	2.0	1.5
HbA1C	1.8	2.0	6.1	1.7	0.8	1.1	0.9	2.5	0.6
Vitamin and mineral supplements	1.8	2.4	6.5	-2.5	-1.9	-1.9	0.4	-0.8	-0.0
Had menopause	1.8	2.2	7.3	2.7	1.9	1.3	-0.7	0.2	0.1
Medication: Cholesterol lowering	1.8	2.9	5.2	2.3	1.6	2.1	-0.3	1.6	1.5
Supplements: Vitamin C	1.8	2.1	4.0	1.8	2.0	2.0	0.5	1.1	0.1
Average weekly beer plus cider intake	1.8	2.6	6.1	-2.5	-2.0	-1.9	-0.9	-1.2	0.2
Rheumatoid Arthritis	1.7	2.3	3.2	1.2	1.8	1.7	-0.8	1.6	1.7
Type 2 Diabetes (T2D) (2012)	1.7	2.0	4.3	-1.7	-2.1	-1.8	-0.8	-0.8	-0.4
Cardiovascular Disease	1.7	5.6	9.3	1.6	2.4	2.8	1.6	2.4	3.0
Medication: Metformin	1.6	2.2	6.2	2.5	1.4	1.7	0.1	1.4	0.3
Had other major operations	1.6	1.9	3.0	-1.7	-1.5	-1.6	-1.1	-1.4	-0.8
Diabetes (self-reported)	1.6	2.4	7.6	2.8	0.6	1.2	-1.1	1.8	0.8
Had major operations	1.6	1.8	4.2	-1.2	-2.1	-1.4	-1.8	-0.0	0.0
Eye problems/disorders: Cataract	1.6	1.9	2.7	-0.6	-1.6	-1.6	-1.4	-1.3	-1.5
Current tobacco smoking	1.5	2.5	4.5	0.5	2.1	2.0	2.0	1.0	0.9
Time employed in main current job	1.5	1.7	4.2	-0.1	1.2	1.4	0.9	1.3	2.1
Lung cancer (father)	1.5	1.7	3.6	-1.0	-1.5	-1.9	-0.8	-1.4	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	3.4	0.7	1.5	1.5	1.0	1.9	1.4
Friendships satisfaction	1.5	1.9	3.6	0.7	1.9	1.6	1.5	1.6	0.3
Smoking Status	1.4	3.4	5.8	1.0	2.2	2.3	2.4	1.7	0.7
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	2.2	-0.4	-1.3	-1.4	-1.2	-1.5	-1.3
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.9	0.6	-0.6	-1.0	-1.2	-1.7	-2.0
Medication for cholesterol	1.4	2.1	2.7	-1.0	-1.6	-1.5	-1.2	-1.6	-1.6
Myopia	1.4	2.0	5.5	2.3	1.5	1.6	-0.8	1.0	0.4
Schizophrenia (2018)	1.3	2.7	5.2	0.0	-1.4	-2.1	-2.3	-1.8	-1.2
Body Mass Index (BMI) (2010)	1.3	1.8	2.8	-0.2	1.7	1.3	1.7	0.8	1.7
Medication: Amlodipine	1.3	1.8	4.0	1.1	1.1	1.4	0.3	1.6	2.0
High blood pressure (siblings)	1.3	1.8	4.3	1.2	2.1	1.9	1.0	0.6	0.7
Mean time to correctly identify matches	1.3	2.6	3.8	1.9	1.7	1.9	0.3	2.0	1.2
Bipolar Disorder (2011)	1.2	1.2	2.6	0.3	0.8	1.1	0.9	1.6	1.4
Crohns Disease (2012)	1.2	1.9	4.7	2.2	1.6	1.6	0.2	1.0	0.8
Number of treatments/medications taken	1.2	2.2	2.9	1.6	1.6	1.7	-1.1	1.6	1.2
Illnesses of mother	1.2	1.5	5.6	-2.4	-1.1	-1.0	0.4	-1.0	-0.4
Alcohol intake frequency.	1.2	2.8	5.4	0.4	2.3	1.9	1.2	1.3	2.1
Systolic Blood Pressure	1.1	5.6	9.1	1.9	2.0	2.6	1.8	3.0	2.7
Ever had hysterectomy (womb removed)	1.1	1.3	2.4	1.1	1.2	1.4	0.7	1.6	0.4
Medication: Co-codamol	1.1	1.3	2.2	-1.4	-1.2	-1.5	0.1	-1.4	-0.6
Hearing difficulty/problems with background noise	1.1	1.8	6.8	-0.4	-0.9	-1.3	-1.1	-2.6	-0.3
Father’s age at death	1.1	1.5	2.6	-0.2	-1.6	-1.5	-1.3	-0.9	-1.3
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	4.7	-0.9	-1.4	-1.2	-1.2	-0.6	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	4.4	-0.0	0.1	0.9	0.4	2.1	1.5
Medication for pain relief, constipation, heartburn	1.1	1.9	4.9	-1.6	-0.3	-1.1	0.2	-2.2	-1.5
Diabetes diagnosed by doctor	1.1	1.8	5.4	2.3	0.5	1.1	-0.8	1.8	0.5
Commuting to job workplace: Public transport	1.1	1.3	2.6	0.7	1.2	1.2	1.6	0.8	1.0
Medication: Bendroflumethiazide	1.1	1.7	3.1	1.4	1.8	1.5	0.9	1.0	1.1
Fractured/broken bones in last 5 years	1.1	1.4	6.0	1.0	-0.6	-0.2	-2.5	0.5	-1.0
Major Depression (MDD)	1.0	1.2	2.4	0.9	1.0	1.0	1.2	0.6	1.5
Blood White Count	1.0	7.4	16.9	-0.2	0.8	1.9	3.4	3.5	4.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.4	1.1	1.5	1.2	1.2	0.6	-0.4
Impedance of leg (left)	1.0	4.8	10.1	-3.2	-3.0	-2.6	-0.6	-1.2	-1.0
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.4	1.2	1.8	1.3	0.6	0.6	0.4
Noisy workplace	1.0	1.2	5.3	0.0	-0.3	0.7	0.6	2.3	1.0
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.0	1.7	1.4	1.4	-0.4	0.9	-0.0
Depression (Nagel 2018)	0.9	1.4	2.6	0.4	1.0	1.1	1.6	1.2	1.4
Mean Putamen Volume	0.9	1.1	2.4	-0.0	-0.2	-0.8	-1.2	-1.4	-1.6
Blood Platelet Count	0.9	10.6	23.4	-3.7	-2.9	-1.6	4.8	-0.0	-4.0
Hearing difficulty/problems: Yes	0.9	1.4	3.2	-0.3	-0.8	-1.2	-1.8	-1.5	-0.8
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.4	1.1	1.2	1.2	-0.1	0.3	1.5
Number of incorrect matches in round	0.9	1.5	3.8	0.4	1.0	1.2	1.2	1.9	1.2
Allergy	0.9	2.1	4.0	1.2	1.7	2.0	1.1	1.2	1.3
Pain all over the body in last month	0.9	1.0	1.8	1.3	1.1	1.0	-1.2	0.6	0.7
Blood clot in the leg (DVT)	0.9	1.2	2.7	-0.3	0.4	0.8	1.6	1.4	1.3
Neck or shoulder pain in last month	0.9	1.2	4.9	-0.2	-0.4	-1.0	-0.1	-1.1	-2.2
Knee pain experienced in last month	0.9	1.3	3.0	1.1	-0.3	-0.6	-1.7	-1.3	-1.3
Number of self-reported non-cancer illnesses	0.9	1.5	3.7	0.6	0.8	1.4	-0.6	1.9	1.4
Basal cell carcinoma (self-reported)	0.9	1.1	2.1	0.2	-1.3	-1.1	-1.2	0.2	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.4	-0.4	0.1	0.7	1.6	1.4	1.4
Crohns Disease (2017)	0.8	1.7	3.6	1.9	1.9	1.5	0.8	0.2	0.6
HDL Cholesterol	0.8	1.3	2.1	-1.1	-1.1	-1.4	1.5	-1.0	-0.5
Chronotype (morning person)	0.8	1.9	4.6	1.2	2.1	1.6	1.2	0.5	1.0
Supplements: Glucosamine	0.8	1.0	3.6	0.7	-0.5	-0.6	-1.9	-0.4	-1.1
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.7	0.8	0.4	0.8	-1.1	1.3	1.3
Financial difficulties in last 2 years	0.8	1.1	2.8	1.3	0.6	0.6	1.7	0.8	0.8
Pulse wave reflection index	0.8	1.0	2.4	1.1	-0.0	0.8	-1.4	1.5	0.2
Number of children fathered	0.8	0.9	2.9	-1.7	-1.0	-0.7	-0.1	-0.1	0.9
Age at last live birth	0.8	1.2	2.1	-0.7	-1.2	-0.9	-1.1	-1.2	-1.4
Mineral and other dietary supplements	0.8	1.1	2.2	-1.5	-1.1	-1.2	1.1	-0.8	-0.1
Hearing aid user	0.8	0.9	4.1	-2.0	-0.4	-0.6	-0.8	-0.6	-0.1
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.7	0.4	-0.1	-0.8	-0.7	-1.4	-1.6
Cholesterol lowering medication	0.8	1.2	2.8	1.3	0.8	1.2	0.0	1.7	0.8
Neuroticism (2016)	0.7	0.9	3.3	1.2	-0.3	-0.3	-0.6	-0.7	-1.8
Impedance of leg (right)	0.7	3.5	8.0	-2.8	-2.7	-2.1	-0.6	-0.6	-0.6
Hand grip strength (right)	0.7	1.9	3.0	-1.4	-1.7	-1.6	-0.2	-0.8	-1.7
Multivitamins +/- minerals	0.7	0.9	3.2	1.8	0.9	0.8	-0.6	0.1	-0.7
Hair/balding pattern: Pattern 2	0.7	0.9	1.6	-0.4	-1.0	-1.1	-1.3	-1.2	-0.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.9	-0.1	-0.8	-1.0	-1.4	-0.7	-1.1
Length of working week for main job	0.7	0.8	2.9	-1.0	0.1	0.1	1.7	-0.2	0.9
Wheeze or whistling in the chest in last year	0.7	1.2	3.5	-0.9	-0.7	-1.3	-0.5	-1.9	-0.7
Qualifications: College or University degree	0.7	2.1	5.1	-0.5	-2.3	-1.7	-1.5	-0.9	-1.1
Medication: Ibuprofen	0.7	0.9	2.0	1.4	1.4	1.1	-0.0	0.3	-0.2
Number of full sisters	0.7	0.8	2.6	0.9	0.1	0.8	0.4	1.6	0.9
Medication: Aspirin	0.7	0.9	3.0	0.8	-0.0	0.7	-0.1	1.7	1.2
Mother’s age at death	0.7	0.9	3.8	0.1	-0.5	-0.2	-1.9	0.4	-1.1
Number of operations (self-reported)	0.7	1.0	4.9	-0.2	-1.0	-0.5	-2.2	0.1	-0.0
Impedance of whole body	0.7	3.8	6.4	-2.3	-2.5	-2.4	0.1	-1.3	-1.9
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.2	0.0	-0.6	-1.2	-1.7	-1.8	-1.6
Schizophrenia (2014)	0.6	1.4	3.6	-0.1	-1.0	-1.5	-1.9	-1.0	-1.0
Neuroticism	0.6	1.4	2.7	1.5	1.2	1.3	1.6	0.7	-0.1
Supplements: Zinc	0.6	0.6	2.0	-1.4	-0.5	-0.2	-0.8	-0.2	0.8
Diabetes (father)	0.6	0.8	2.5	0.5	0.3	0.7	-0.3	1.1	1.6
Maternal smoking around birth	0.6	0.9	1.9	-0.1	-0.1	-1.1	0.4	-1.4	-1.4
Taking other prescription medications	0.6	0.9	4.2	0.0	-0.7	-0.4	-2.0	0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	5.4	-0.4	0.8	0.8	0.9	0.8	2.3
Waist circumference	0.6	2.3	3.2	1.4	1.7	1.6	0.4	1.7	1.8
Number of live births	0.6	0.9	1.9	-0.4	-1.2	-0.5	-1.4	0.6	1.0
Asthma	0.6	1.2	2.8	-1.7	-0.5	-1.0	1.0	-1.2	0.9
Exposure to tobacco smoke at home	0.6	0.7	1.4	0.8	-0.7	-1.2	-1.0	-0.8	-0.4
Health satisfaction	0.6	0.8	2.8	-0.5	-0.0	-0.5	-1.2	-0.4	-1.7
Medication: Aspirin	0.6	0.9	2.8	0.9	-0.4	0.4	-0.3	1.7	1.1
Loneliness, isolation	0.6	0.8	2.2	-0.8	-0.5	-1.1	0.3	-1.5	-0.7
Ever had bowel cancer screening	0.6	0.7	2.3	0.3	-0.7	-0.4	-1.5	-0.3	-1.2
Breast cancer (self-reported)	0.6	0.7	1.8	-0.3	-0.5	-0.4	-1.4	-1.1	-0.6
Asthma (self-reported)	0.6	1.2	2.7	-1.6	-0.4	-1.0	0.9	-1.3	0.8
Average weekly champagne plus white wine intake	0.6	0.9	4.3	0.2	0.7	0.4	2.1	0.2	0.5
Miserableness	0.6	1.0	1.5	1.0	1.2	1.2	1.2	0.5	-0.7
Irritability	0.6	1.0	2.6	-0.1	0.6	0.9	1.6	1.4	0.7
Ever had prostate specific antigen (PSA) test	0.6	0.7	3.2	1.8	0.4	0.1	-0.4	-0.4	-0.5
Bipolar Disorder (2018)	0.5	0.7	1.8	0.1	1.4	1.0	0.4	0.5	1.1
Neuroticism (Nagel 2018)	0.5	1.1	4.0	2.0	0.8	0.9	0.6	0.4	-0.6
Schizophrenia vs Biploar Disorder	0.5	0.6	1.4	-0.8	-0.4	-0.8	-0.7	-1.2	-0.6
Ulcerative Colitis (UC)	0.5	0.9	2.9	-1.0	-0.0	-0.1	1.7	-1.1	-0.2
Lupus	0.5	0.8	2.3	0.1	0.4	-0.5	-0.0	-1.5	-1.5
Triglycerides	0.5	0.8	1.2	0.7	0.9	1.1	-1.0	1.1	0.4
Waist Hip Ratio (WHR)	0.5	2.4	4.1	1.4	1.0	1.3	1.6	1.7	2.0
Pack years adult smoking proportion	0.5	0.7	2.2	-0.2	0.1	0.5	1.0	0.9	1.5
Townsend deprivation index at recruitment	0.5	0.7	1.7	-1.3	0.0	-0.3	1.2	-0.7	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.0	0.5	1.0	0.9	0.9	1.0	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.6	-0.9	-1.2	-1.2	-1.0	-0.4	-0.2
Medication: Ramipril	0.5	0.6	2.2	-1.5	-0.6	-0.6	-0.1	0.2	0.9
Fluid intelligence score	0.5	1.0	1.9	1.1	0.6	-0.0	-0.9	-1.4	-1.4
Illnesses of siblings	0.5	0.7	1.1	-1.0	-1.0	-1.0	-0.5	-0.6	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.8	-1.3	-0.9	-0.8	-0.5	-0.3	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	2.8	1.7	1.5	1.1	1.2	0.3	-1.3
Gout (self-reported)	0.5	0.7	1.5	0.2	0.9	1.0	1.2	0.9	0.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.3	-1.1	-1.0	-0.8	-0.6	0.0	0.1
Age at first live birth	0.5	0.9	2.4	-0.4	-0.7	-0.6	-0.1	-1.5	-1.5
Medication: Allopurinol	0.5	0.7	1.3	0.6	0.7	0.8	1.1	1.1	0.3
Comparative height size at age 10	0.5	3.0	4.5	2.1	1.8	0.7	1.9	-1.3	-2.1
Chest pain or discomfort	0.5	0.7	1.3	-0.7	-1.1	-1.1	0.0	-1.1	-0.3
Leg pain on walking	0.5	0.6	1.1	-0.9	-0.7	-0.9	0.7	-1.0	-0.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.0	-1.4	-0.8	-0.8	-0.4	-0.3	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.7	-1.3	-0.0	-0.1	1.1	-0.2	-0.3
Guilty feelings	0.5	0.8	1.7	1.3	0.8	0.7	-0.3	-0.6	-1.1
Wears glasses or contact lenses	0.5	0.6	1.8	-0.6	-0.1	0.5	-0.1	0.9	1.4
Ever taken oral contraceptive pill	0.5	0.6	1.8	-1.3	-0.5	-0.4	0.7	0.0	0.9
High cholesterol (Self-reported)	0.5	1.0	2.9	0.6	0.4	1.2	-0.9	1.7	0.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.7	0.3	-0.9	-1.0	-0.4	-1.3	-0.5
Supplements: Calcium	0.5	0.5	2.5	-0.2	-0.3	-0.0	0.3	0.6	1.6
Pack years of smoking	0.5	0.7	2.2	-0.0	-0.0	0.5	0.7	1.1	1.5
Depressed Affect (Nagel 2018)	0.4	0.9	2.0	1.0	1.2	0.8	1.4	-0.0	-0.3
Primary Biliary Cirrhosis	0.4	0.5	1.0	1.0	0.7	0.4	0.9	0.2	-0.9
Blood Red Count	0.4	3.4	4.9	2.0	1.0	1.9	-2.2	1.6	2.1
Respiratory disease	0.4	1.0	1.9	-1.4	-0.7	-0.8	0.7	-0.5	1.4
Lung FVC	0.4	1.9	5.0	-0.3	-1.6	-1.3	-1.5	0.1	-2.2
Average weekly spirits intake	0.4	0.5	1.2	1.1	0.1	0.2	1.1	0.5	-0.2
Sensitivity / hurt feelings	0.4	0.6	1.9	1.4	0.3	0.6	-0.1	0.8	-0.8
Leg fat-free mass (left)	0.4	2.2	5.3	1.5	2.3	1.3	1.9	-0.2	0.4
Leg predicted mass (left)	0.4	2.3	5.3	1.5	2.3	1.3	2.1	-0.1	0.5
Alcohol usually taken with meals	0.4	0.7	2.7	0.2	-0.5	-0.7	0.1	-0.9	-1.6
Mouth/teeth dental problems	0.4	0.6	1.8	-0.7	0.2	0.6	0.7	1.3	0.6
Impedance of arm (right)	0.4	2.0	4.3	-0.8	-1.7	-1.7	0.1	-1.2	-2.1
Worrier / anxious feelings	0.4	0.7	1.1	1.0	0.8	1.0	0.9	0.6	0.7
Hair/balding pattern: Pattern 3	0.4	0.5	1.3	1.1	0.1	0.2	0.0	1.1	-0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.5	1.2	1.3	1.0	1.6	0.2	-0.9
Pulse rate	0.4	0.7	2.3	-0.4	-0.3	-0.9	0.3	-1.5	-0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.7	0.1	-0.8	-0.6	1.0	0.1	-1.9
Mouth/teeth dental problems: Dentures	0.4	0.7	1.8	1.3	1.1	0.8	-0.4	-0.2	0.1
Breastfed as a baby	0.4	0.5	1.3	1.1	-0.3	0.4	-0.6	1.1	-0.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.8	-0.9	0.3	-0.1	-0.2	-1.3	0.1
Arm fat-free mass (right)	0.4	2.1	5.3	1.1	2.3	1.4	1.7	0.1	1.0
Number of full brothers	0.4	0.5	1.1	-0.3	0.5	-0.1	-0.9	-0.9	-1.1
Worry too long after embarrassment	0.4	0.6	1.7	0.5	-0.7	-0.7	-0.3	-0.8	-1.3
Shortness of breath walking on level ground	0.4	0.4	1.6	-1.3	0.2	-0.0	0.6	-0.8	-0.2
Medication: Seretide 50 evohaler	0.4	0.5	1.4	0.1	-0.2	0.3	0.5	1.0	1.2
Arm predicted mass (right)	0.4	1.9	5.2	1.1	2.3	1.3	1.7	-0.2	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.0	0.1	0.1	0.6	0.7	0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.7	0.6	0.9	0.6	1.7	0.5	-0.2
Leg fat-free mass (right)	0.4	2.3	5.4	1.6	2.3	1.2	2.0	-0.5	0.1
Average weekly red wine intake	0.4	0.6	1.3	-0.5	-0.7	-0.9	-0.7	-1.2	-0.6
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.2	1.1	0.9	0.6	0.4	0.1	-0.4
Long-standing illness, disability or infirmity	0.4	0.6	1.2	1.1	0.5	0.8	0.2	0.9	1.0
Osteoporosis (self-reported)	0.4	0.5	1.9	0.1	0.0	-0.3	-1.4	-0.9	-0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.6	-0.2	-0.1	-0.4	1.3	-0.7	-0.8
Leg predicted mass (right)	0.4	2.2	5.3	1.6	2.3	1.2	2.0	-0.5	0.1
Medication: Atorvastatin	0.4	0.4	1.2	0.5	-1.1	-0.5	-0.9	0.1	0.4
Alcohol drinker status: Never	0.4	0.5	1.7	-0.3	1.3	0.7	0.2	0.6	0.4
Pain experienced in last month	0.4	0.6	1.4	-0.7	-1.0	-0.1	0.4	1.2	0.8
Bipolar Disorder or Schizophrenia	0.3	0.8	2.3	0.1	-0.3	-1.0	-1.5	-1.1	-0.3
Irritable Bowel Disease (IBD)	0.3	0.7	1.7	0.3	0.9	0.6	1.3	-1.1	0.0
Breast Cancer	0.3	0.7	1.4	0.2	1.2	1.1	0.1	1.1	0.4
Ovarian Cancer	0.3	0.4	1.1	0.6	0.1	0.3	0.7	1.1	0.5
Ulcerative Colitis	0.3	0.4	1.0	-0.8	0.1	0.0	0.8	-1.0	-0.1
Height	0.3	5.8	13.5	1.1	0.8	-1.1	3.2	-3.7	-2.9
Hand grip strength (left)	0.3	0.7	2.0	-1.4	-0.5	-0.4	0.8	-0.4	-0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	0.5	0.2	0.5	-0.8	1.0	0.3
Medication for hormone replacement therapy	0.3	0.4	0.8	0.3	0.6	0.6	0.7	0.5	0.9
Severe depression (siblings)	0.3	0.3	0.8	-0.3	-0.6	-0.6	-0.5	-0.1	-0.9
Average weekly fortified wine intake	0.3	0.3	1.6	-0.1	0.3	0.3	0.1	0.3	1.3
Fed-up feelings	0.3	0.5	2.4	-0.3	0.7	0.2	1.5	-0.3	-0.4
Age when periods started (menarche)	0.3	0.7	3.4	-1.8	-0.5	-0.5	-0.1	-0.6	-0.1
Qualifications: CSEs or equivalent	0.3	0.4	1.2	-0.5	-0.0	-0.5	-0.6	-1.1	-0.6
Stomach or abdominal pain in last month	0.3	0.4	1.1	-0.3	0.1	-0.5	0.6	-1.0	-0.7
Forced vital capacity (FVC)	0.3	1.2	4.3	-0.5	-0.4	-0.8	1.0	-1.0	-2.1
Medication: Lansoprazole	0.3	0.3	0.9	0.5	0.7	0.2	-0.5	-1.0	0.2
Impedance of arm (left)	0.3	1.3	2.5	-0.9	-1.4	-1.3	0.6	-0.6	-1.6
Tense / ‘highly strung’	0.3	0.5	1.2	0.7	0.2	0.6	0.3	0.8	1.1
Peak expiratory flow (PEF)	0.3	0.7	1.5	0.8	0.6	0.6	1.2	0.5	-0.9
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	-0.1	-0.4	-0.8	0.3	-0.9	-0.8
Headache pain in last month	0.3	0.4	0.6	-0.6	-0.7	-0.8	-0.4	-0.8	-0.5
Glaucoma (self-reported)	0.3	0.4	1.0	-0.6	-0.2	0.1	-1.0	0.5	-0.7
Pulse wave peak to peak time	0.3	0.3	0.6	0.5	0.3	-0.1	0.7	-0.5	-0.8
Angina (self-reported)	0.3	0.4	1.1	-0.2	-0.5	-0.2	1.0	0.1	0.8
Migraine (self-reported)	0.3	0.3	1.0	1.0	-0.3	0.4	0.2	0.9	-0.2
Medication: Omeprazole	0.3	0.3	0.5	-0.4	-0.7	-0.6	0.4	-0.6	0.7
Pulse rate, automated reading	0.3	1.0	3.0	0.3	0.1	-0.7	-0.6	-1.7	-1.3
Suffer from ‘nerves’	0.3	0.5	1.3	0.7	-0.6	-0.5	-0.7	-0.6	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.7	-0.6	-0.1	-0.1	1.3	-0.2	0.6
Illnesses of siblings: Diabetes	0.3	0.4	1.7	0.5	0.0	0.2	-1.3	0.2	-0.3
Whole body fat-free mass	0.3	1.9	4.4	1.6	2.1	1.2	1.7	-0.3	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.1	-0.2	0.7	0.4	1.0	0.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.6	1.0	-0.4	-0.3	-0.5	0.5	-1.3
Whole body water mass	0.3	1.9	4.5	1.5	2.1	1.2	1.7	-0.3	0.3
Eye problems/disorders: Glaucoma	0.3	0.3	0.8	0.2	0.5	0.8	-0.1	0.9	0.2
Medication: Paracetamol	0.3	0.4	1.5	0.7	0.1	0.1	-1.2	-0.1	-0.7
Basal metabolic rate	0.3	1.6	4.0	1.4	2.0	1.1	1.5	-0.3	0.4
Age started oral contraceptive pill	0.3	0.4	1.3	0.1	-0.2	-0.4	-1.1	-0.2	-0.9
Alcohol drinker status: Previous	0.3	0.4	1.6	0.1	0.5	-0.1	-0.4	-1.3	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	0.7	0.6	0.1	-0.5	-0.9	-0.8
Age at First Birth	0.2	0.3	1.1	0.5	0.0	-0.1	-0.1	-0.6	-1.0
Coronary Artery Disease (CAD)	0.2	0.3	0.8	0.9	0.5	0.2	-0.5	-0.4	-0.0
Blood Eosinophil Count	0.2	1.5	2.6	0.7	1.3	1.3	1.2	0.9	1.6
Heel T-Score	0.2	1.3	3.5	-1.4	0.0	1.1	0.5	1.9	0.8
BMI	0.2	0.9	2.8	1.0	1.7	1.1	0.2	0.4	0.6
Hair Pigment	0.2	5.3	20.7	-2.8	-1.5	-0.5	-4.5	0.5	0.5
Relative age of first facial hair	0.2	0.4	1.3	-0.1	-0.5	-0.5	-1.1	-0.3	-0.5
Angina	0.2	0.3	0.8	-0.4	-0.6	-0.3	0.9	-0.1	0.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	1.0	-0.3	-0.2	-0.2	1.0	0.0	-0.4
Sitting height	0.2	1.1	2.5	0.2	0.2	-0.6	1.6	-1.5	-1.1
Body mass index (BMI)	0.2	0.8	1.7	0.8	1.3	0.8	-0.3	0.6	1.3
Past tobacco smoking	0.2	0.4	1.7	-0.6	-0.5	-0.4	-1.3	-0.2	0.0
Nervous feelings	0.2	0.4	0.8	0.9	0.9	0.6	-0.5	-0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.6	0.0	0.2	0.3	-0.3	0.4	1.6
Heart attack	0.2	0.2	0.7	0.0	-0.8	-0.6	0.1	0.1	0.6
Neuroticism score	0.2	0.5	1.2	0.6	0.6	0.6	1.1	0.2	-0.7
Weight	0.2	0.8	2.3	1.0	1.5	0.7	0.9	-0.1	0.4
Trunk fat-free mass	0.2	1.3	2.7	1.4	1.6	1.0	1.3	-0.3	0.1
Alcohol intake versus 10 years previously	0.2	0.3	0.8	0.5	0.2	-0.0	-0.7	-0.4	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	0.7	0.6	0.4	-0.6	0.2	-0.4
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.3	-0.1	0.2	-0.7	0.4	0.7
Arm fat mass (right)	0.2	0.7	1.9	1.2	1.4	0.7	0.0	0.1	0.5
Trunk predicted mass	0.2	1.4	3.0	1.5	1.7	1.0	1.4	-0.3	0.2
Standing height	0.2	2.3	5.4	0.7	0.4	-0.5	2.3	-1.8	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.5	0.2	0.4	0.8	0.4	0.6
Hair/balding pattern: Pattern 4	0.2	0.4	1.0	0.7	0.2	0.2	-1.0	-0.2	-0.9
Medication: Paracetamol	0.2	0.3	1.1	0.5	-0.1	0.0	-1.0	0.3	-0.8
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	-0.3	0.4	0.6	0.2	0.7	0.5
Birth weight	0.2	0.5	1.0	0.1	0.9	1.0	-0.7	0.5	0.8
Forced vital capacity (FVC), Best measure	0.2	0.7	2.4	0.3	0.3	0.1	1.2	0.1	-1.6
Leg fat percentage (right)	0.2	0.6	1.6	-0.5	-0.1	-0.1	-1.1	0.7	1.3
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.8	0.1	0.1	0.3	0.9	0.1	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	-0.4	-0.6	0.0	-0.7	0.3	0.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	1.3	-1.1	-0.4	-0.2	0.3	0.1	0.4
Illnesses of father: Heart disease	0.2	0.2	0.6	0.2	0.4	0.6	-0.8	0.6	0.1
Mood swings	0.2	0.3	0.9	-0.1	0.1	-0.3	0.7	-0.7	-1.0
Qualifications: nursing, teaching	0.2	0.3	0.5	-0.7	-0.6	0.2	0.6	0.6	0.4
Commuting to job workplace: Walk	0.2	0.2	0.5	0.7	-0.5	-0.1	-0.7	0.2	0.2
Osteoarthritis (self-reported)	0.2	0.3	0.9	0.8	-0.2	0.3	0.1	0.9	0.1
Arm fat mass (left)	0.2	0.7	2.1	1.0	1.5	0.8	0.2	0.2	0.8
Illnesses of father: High blood pressure	0.2	0.3	1.3	1.2	0.2	0.4	-0.4	0.2	0.3
Ever smoked	0.2	0.3	1.5	-0.2	0.4	0.3	1.2	-0.2	-0.1
Arm fat-free mass (left)	0.2	1.1	3.0	1.2	1.7	0.8	0.9	-0.5	0.3
Risk taking	0.2	0.3	1.1	-0.1	0.2	0.4	0.6	0.3	1.0
Diastolic blood pressure, automated reading	0.2	0.7	1.4	0.1	0.5	0.7	-0.9	1.0	1.2
Ever depressed for a whole week	0.2	0.2	0.7	0.8	0.5	0.3	0.3	-0.4	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.8	-0.1	-0.9	-0.8	-0.1	-0.1	0.5
Heart disease (siblings)	0.2	0.3	0.4	0.6	0.6	0.6	0.3	0.2	0.6
Arm predicted mass (left)	0.2	1.2	3.5	1.2	1.9	0.9	1.1	-0.6	0.4
Worry (Nagel 2018)	0.1	0.2	0.6	0.8	0.1	0.5	0.3	0.6	0.4
Alzheimer’s Disease (in mother)	0.1	0.2	0.7	0.3	-0.2	-0.1	0.8	0.4	-0.1
Alzheimer’s Disease (including proxy)	0.1	0.1	0.5	0.2	0.1	0.2	0.7	0.3	-0.3
LDL Cholesterol	0.1	0.2	0.5	0.7	0.1	0.2	-0.3	0.7	-0.3
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.6	0.2	0.6	0.5	0.8	0.1	0.2
Relative age voice broke	0.1	0.1	0.3	-0.2	-0.2	-0.0	0.5	0.5	0.1
Serious illness, injury or assault to yourself	0.1	0.2	0.6	0.8	0.4	0.5	-0.1	-0.0	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.4	-0.0	0.0	-0.3	-0.3	-0.3	-0.6
Trunk fat mass	0.1	0.3	1.2	0.6	1.1	0.3	0.4	-0.2	0.4
Qualifications: None of the above	0.1	0.2	0.6	-0.3	-0.4	-0.7	-0.2	-0.8	0.0
Arm fat percentage (right)	0.1	0.2	0.5	0.5	0.7	0.3	-0.2	0.2	0.5
Hip circumference	0.1	0.6	1.3	0.6	1.2	0.8	0.1	0.8	0.8
Exposure to tobacco smoke outside home	0.1	0.1	0.4	-0.3	0.0	-0.2	-0.2	-0.5	-0.7
Comparative body size at age 10	0.1	0.3	0.9	0.1	0.9	0.1	0.6	-0.6	-0.6
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.5	-0.1	-0.2	-0.1	-0.3	0.3
Heart disease (mother)	0.1	0.1	0.2	-0.3	-0.4	-0.3	-0.4	-0.3	-0.0
Whole body fat mass	0.1	0.4	1.4	0.6	1.2	0.4	0.3	-0.1	0.6
Leg fat mass (right)	0.1	0.3	1.0	0.0	0.8	0.3	-0.3	0.3	1.0
Overall health rating	0.1	0.3	1.3	-1.1	0.1	-0.3	0.5	0.1	-0.1
Smoking status: Previous	0.1	0.2	0.4	0.1	-0.6	-0.4	0.4	-0.1	-0.5
Arm fat percentage (left)	0.1	0.3	0.7	0.3	0.8	0.4	0.0	0.4	0.8
Back pain experienced in last month	0.1	0.2	0.6	0.4	0.5	-0.0	0.8	-0.1	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.8	-0.1	0.1	0.2	-0.9	0.2	-0.3
Leg fat percentage (left)	0.1	0.5	1.3	-0.6	-0.2	-0.2	-0.9	0.4	1.1
Unable to work because of sickness or disability	0.1	0.1	0.3	0.6	-0.0	0.3	0.2	0.4	0.4
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.1	-0.4	-0.3	-0.3	-0.5	-0.2
Leg fat mass (left)	0.1	0.4	1.1	0.0	0.9	0.4	0.0	0.4	1.1
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.2	-0.2	-0.0	0.1	0.2	-0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.3	1.0	0.0	0.0	0.3	1.0	0.2	0.6
Trunk fat percentage	0.0	0.1	0.3	0.2	0.6	-0.1	0.0	-0.4	0.0
Body fat percentage	0.0	0.1	0.2	-0.3	0.3	-0.2	-0.2	-0.2	0.4

Hub : Genes

TSTD2

Models

Trait associations