[Hub]/) : Traits : Lung FEV1/FVC ratio :

chr10:30,411,253-32,016,090

Best TWAS P=1.49e-13 · Best GWAS P=4.11e-14 conditioned to 0.333

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Aorta ZNF438 0.12 0.00 enet 10 0.03 1.3e-02 -6.7 -6.0 1.6e-09 0.83 0.05 0.80 FALSE
2 GTEx Artery Tibial ZNF438 0.14 0.03 lasso 9 0.08 6.1e-07 2.6 -5.8 8.8e-09 0.73 0.12 0.83 FALSE
3 GTEx Esophagus Muscularis ZNF438 0.08 0.07 enet 9 0.07 4.7e-05 -7.4 -7.4 1.5e-13 0.89 0.01 0.99 TRUE
4 GTEx Pituitary ZNF438 0.29 0.01 enet 17 0.03 5.2e-02 5.3 6.1 1.3e-09 -0.48 0.07 0.18 FALSE
5 GTEx Testis ZNF438 0.23 0.21 enet 20 0.23 1.9e-10 5.8 -6.7 3.0e-11 0.76 0.12 0.87 FALSE
6 The Cancer Genome Atlas Lung Adenocarcinoma ZNF438 0.07 0.03 lasso 5 0.04 1.9e-05 6.0 5.3 1.1e-07 -0.26 0.90 0.02 TRUE
7 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ZNF438 0.07 0.01 blup 123 0.03 1.9e-02 2.8 -5.1 3.1e-07 0.74 0.04 0.39 FALSE