Best TWAS P=1.49e-13 · Best GWAS P=4.11e-14 conditioned to 0.333
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ZNF438 | 0.12 | 0.00 | enet | 10 | 0.03 | 1.3e-02 | -6.7 | -6.0 | 1.6e-09 | 0.83 | 0.05 | 0.80 | FALSE |
| 2 | GTEx | Artery Tibial | ZNF438 | 0.14 | 0.03 | lasso | 9 | 0.08 | 6.1e-07 | 2.6 | -5.8 | 8.8e-09 | 0.73 | 0.12 | 0.83 | FALSE |
| 3 | GTEx | Esophagus Muscularis | ZNF438 | 0.08 | 0.07 | enet | 9 | 0.07 | 4.7e-05 | -7.4 | -7.4 | 1.5e-13 | 0.89 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Pituitary | ZNF438 | 0.29 | 0.01 | enet | 17 | 0.03 | 5.2e-02 | 5.3 | 6.1 | 1.3e-09 | -0.48 | 0.07 | 0.18 | FALSE |
| 5 | GTEx | Testis | ZNF438 | 0.23 | 0.21 | enet | 20 | 0.23 | 1.9e-10 | 5.8 | -6.7 | 3.0e-11 | 0.76 | 0.12 | 0.87 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | ZNF438 | 0.07 | 0.03 | lasso | 5 | 0.04 | 1.9e-05 | 6.0 | 5.3 | 1.1e-07 | -0.26 | 0.90 | 0.02 | TRUE |
| 7 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ZNF438 | 0.07 | 0.01 | blup | 123 | 0.03 | 1.9e-02 | 2.8 | -5.1 | 3.1e-07 | 0.74 | 0.04 | 0.39 | FALSE |