Hub : Genes

ZNF438

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0600 0.0220 4.1e-04 0.051 0.023 0.034 0.022 0.030 7.9e-07 7.5e-04 4.3e-05 8.7e-04 1.3e-04
2 GTEx Artery Aorta 0.1240 0.0510 6.3e-03 -0.004 NA 0.027 NA 0.008 6.9e-01 NA 1.3e-02 NA 1.1e-01
3 GTEx Artery Tibial 0.1363 0.0423 1.5e-05 0.031 NA 0.065 NA 0.081 1.6e-03 NA 8.0e-06 NA 6.1e-07
4 GTEx Esophagus Muscularis 0.0850 0.0300 6.5e-04 0.070 NA 0.070 NA 0.063 4.4e-05 NA 4.7e-05 NA 1.1e-04
5 GTEx Pituitary 0.2890 0.1090 7.6e-03 0.010 NA 0.033 NA 0.016 1.7e-01 NA 5.2e-02 NA 1.3e-01
6 GTEx Testis 0.2300 0.0630 1.1e-06 0.211 NA 0.227 NA 0.205 1.0e-09 NA 1.9e-10 NA 1.8e-09
7 GTEx Thyroid 0.1330 0.0410 6.0e-05 0.033 NA 0.063 NA 0.043 1.4e-03 NA 1.4e-05 NA 2.8e-04
8 GTEx Whole Blood 0.0750 0.0320 1.6e-03 0.003 NA -0.003 NA -0.003 1.6e-01 NA 7.5e-01 NA 8.8e-01
9 ROSMAP Brain Pre-frontal Cortex 0.1134 0.0323 1.2e-07 0.051 0.061 0.043 0.064 0.068 3.7e-07 2.9e-08 2.8e-06 1.3e-08 4.6e-09
10 YFS Blood 0.0202 0.0076 1.1e-03 0.003 0.008 0.004 0.009 0.004 2.6e-02 9.8e-04 1.2e-02 3.4e-04 2.0e-02
11 TCGA Breast Invasive Carcinoma 0.0295 0.0126 2.1e-05 0.001 0.022 0.015 NA 0.010 1.5e-01 1.8e-05 4.0e-04 NA 3.1e-03
12 TCGA Glioblastoma Multiforme 0.2040 0.1010 4.6e-03 0.125 0.088 0.063 NA 0.079 1.3e-04 1.3e-03 5.5e-03 NA 2.2e-03
13 TCGA Head and Neck Squamous Cell Carcinoma 0.0961 0.0368 6.2e-06 0.038 0.035 0.024 NA 0.036 4.1e-05 6.8e-05 9.3e-04 NA 5.9e-05
14 TCGA Kidney Renal Clear Cell Carcinoma 0.0423 0.0227 1.7e-03 0.021 0.021 0.020 NA 0.025 1.8e-03 1.7e-03 2.2e-03 NA 6.8e-04
15 TCGA Brain Lower Grade Glioma 0.0948 0.0383 1.8e-06 0.030 0.034 0.035 NA 0.032 2.2e-04 8.1e-05 7.1e-05 NA 1.4e-04
16 TCGA Lung Adenocarcinoma 0.0735 0.0292 5.2e-06 0.029 0.028 0.031 NA 0.039 2.0e-04 2.6e-04 1.3e-04 NA 1.9e-05
17 TCGA Pheochromocytoma and Paraganglioma 0.0690 0.0400 9.5e-03 0.014 0.033 0.024 NA 0.029 8.5e-02 1.9e-02 3.7e-02 NA 2.4e-02
18 TCGA Prostate Adenocarcinoma 0.0563 0.0292 5.5e-04 0.022 0.021 0.017 NA 0.023 1.9e-03 2.4e-03 5.8e-03 NA 1.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Bipolar Disorder (2018) 0.2 0.4 2.1 0.0 -1.0 -0.3 -0.6 1.4 -0.1 0.6 0.0 1.0 0.1 0.8 0.1 0.3 -0.6 0.5 -0.4 -0.3 0.5
Bipolar Disorder or Schizophrenia 0.3 0.7 3.9 0.9 -0.7 0.8 -0.0 0.8 0.8 1.3 0.0 2.0 1.0 1.2 0.0 0.2 -0.3 0.6 -0.8 0.2 0.8
Depressed Affect (Nagel 2018) 0.7 1.4 6.1 0.9 -0.2 1.8 1.4 -0.6 1.2 2.5 0.0 2.0 0.5 1.1 -0.4 -0.7 0.4 0.1 -1.2 1.3 1.3
Depression (Nagel 2018) 0.5 0.8 3.4 0.8 -0.2 1.8 0.7 0.2 0.5 1.3 0.0 1.8 1.1 0.6 -0.3 -0.6 -0.0 0.5 -1.2 0.4 0.9
Intelligence (Savage-Jansen 2018) 1.5 4.6 14.4 -0.2 3.5 2.0 3.0 -3.8 3.1 0.7 0.0 0.5 0.3 -2.0 0.1 -2.4 0.8 -2.7 -3.3 1.9 0.7
Neuroticism (Nagel 2018) 1.3 3.0 14.3 1.4 -0.3 1.6 1.8 -0.1 1.6 3.8 0.0 2.8 -0.6 2.6 -0.0 -0.3 1.2 1.0 -0.7 1.8 2.9
Schizophrenia (2018) 0.3 0.7 3.0 1.1 -0.2 1.3 0.5 -0.2 1.1 1.0 0.0 1.7 1.3 0.9 -0.1 0.0 0.1 0.4 -0.7 0.5 0.6
Schizophrenia vs Biploar Disorder 0.3 0.4 1.9 0.8 0.1 0.6 0.7 -0.8 0.9 -0.0 0.0 0.5 1.4 -0.1 -0.7 -0.7 0.2 -0.0 -0.5 0.1 0.1
Worry (Nagel 2018) 1.3 2.7 14.6 1.0 -0.4 0.6 1.2 0.4 1.4 3.8 0.0 2.6 -1.3 2.9 0.1 -0.5 0.8 1.3 0.1 1.5 2.8
Alzheimer’s Disease (in mother) 0.3 0.3 2.0 -0.9 0.5 -0.1 -0.2 -0.3 -0.6 -0.2 0.0 -0.4 -0.8 -0.7 0.6 -0.1 -0.3 -0.6 -1.4 0.1 -0.2
Alzheimer’s Disease (in father) 0.8 0.8 3.6 1.2 0.3 1.9 0.4 -0.1 0.2 0.4 0.0 1.8 1.4 0.9 0.7 -0.3 0.0 0.9 -0.7 0.9 0.9
Alzheimer’s Disease (including proxy) 0.2 0.4 2.1 -0.3 0.3 0.7 0.3 -0.1 -1.0 0.6 0.0 0.2 -0.5 0.1 1.5 0.2 -0.1 0.0 -1.2 0.6 0.1
Crohns Disease (2017) 0.6 1.3 12.1 -0.5 -0.2 -1.0 -0.8 0.6 -3.5 -1.1 0.0 -1.6 -0.7 -0.5 1.4 1.2 0.0 -0.0 1.1 -0.4 -0.2
Irritable Bowel Disease (IBD) 0.5 1.2 7.1 -0.9 -1.1 -2.3 -0.7 0.5 -2.7 -0.6 0.0 -1.7 -1.0 -0.3 0.9 0.5 -0.2 -0.2 0.7 -0.7 -0.5
Ulcerative Colitis (UC) 0.8 1.5 8.8 -1.6 -1.7 -3.0 -0.9 -0.2 -1.6 -0.9 0.0 -1.8 -0.1 -0.6 -0.5 -0.6 -1.0 -0.7 0.1 -1.3 -1.2
Major Depression (MDD) 0.4 0.5 1.5 -1.2 -0.6 -0.9 -0.4 0.4 -0.3 0.6 0.0 -0.7 0.0 -0.2 -0.8 -0.8 -1.1 -1.0 -0.5 -0.7 -0.8
Reaction Time 1.0 1.9 6.4 1.1 -0.6 1.6 -0.2 2.2 -0.1 0.2 0.0 1.1 -1.1 2.2 0.4 1.8 1.2 2.5 2.3 0.7 0.8
Verbal and Numeric Reasoning (VNR) 1.5 3.5 16.9 -0.5 1.3 1.4 1.9 -3.0 2.7 0.9 0.0 0.8 1.0 -1.5 -0.8 -3.0 -0.4 -2.6 -4.1 0.8 0.7
Breast Cancer 1.3 3.0 10.7 0.8 3.0 1.7 2.7 0.1 3.3 1.1 0.0 0.2 -2.2 -0.1 1.5 0.2 2.4 -0.1 0.4 2.9 1.2
Ovarian Cancer 2.3 3.1 8.6 -0.4 2.7 1.8 2.5 -1.9 2.9 1.2 0.0 -0.4 -0.5 -1.3 0.2 -2.3 0.6 -2.3 -2.7 2.0 0.4
Prostate Cancer 0.7 0.9 2.4 1.3 0.3 1.1 0.2 -0.0 -1.0 0.9 0.0 1.5 0.5 1.2 1.5 0.8 0.3 1.6 0.5 0.9 1.1
Age at First Birth 1.0 1.4 6.2 -0.9 0.7 0.4 1.2 -1.3 1.3 -0.2 0.0 0.1 1.3 -1.2 -1.2 -2.5 -1.0 -2.0 -1.7 0.5 -0.4
Bipolar Disorder (2011) 1.0 1.0 2.5 -0.9 -1.1 -1.1 -1.3 -0.1 -1.1 -1.3 0.0 -0.4 1.3 -1.0 -0.3 -0.4 -1.6 -0.6 -0.9 -1.2 -1.4
Body Mass Index (BMI) (2010) 0.2 0.2 1.0 -0.4 0.0 -0.5 -0.7 0.4 -0.3 0.0 0.0 -0.3 -0.4 -0.3 0.7 0.4 -0.4 0.1 -0.8 -0.4 -1.0
Coronary Artery Disease (CAD) 1.2 1.4 5.0 -0.0 2.2 -0.0 2.2 -1.2 2.1 1.3 0.0 -0.6 -1.0 -0.5 0.2 -0.7 1.5 -0.7 0.0 1.8 0.5
Crohns Disease (2012) 1.2 1.9 10.8 -1.5 -1.3 -1.4 -1.5 0.5 -3.3 -1.8 0.0 -2.1 0.3 -0.9 0.6 0.6 -1.2 -0.4 0.9 -1.2 -1.1
Mean Putamen Volume 0.6 0.7 2.9 -0.0 0.3 -0.0 0.1 1.2 -1.1 0.0 0.0 -0.5 -1.7 0.6 0.8 1.6 0.9 0.8 1.1 0.2 0.7
Fasting Glucose 0.8 0.9 2.7 1.3 0.6 1.6 1.1 -0.9 0.0 0.7 0.0 1.4 0.3 0.5 1.6 0.7 1.0 0.8 -0.3 1.2 0.7
HbA1C 1.1 1.2 7.0 -1.2 -1.2 -2.6 -1.3 0.9 -1.4 0.0 0.0 -1.0 -1.4 0.5 -0.8 -0.5 -0.9 -0.1 0.5 -1.3 0.1
HDL Cholesterol 0.5 0.8 2.7 0.9 1.7 1.6 1.0 -1.2 0.1 -0.1 0.0 0.3 0.1 0.2 0.5 0.6 0.8 0.2 0.9 1.6 1.0
LDL Cholesterol 1.0 1.5 3.8 1.1 0.8 0.7 1.3 0.4 0.5 2.0 0.0 1.2 -0.7 1.8 1.7 1.1 1.2 1.6 1.2 1.9 0.9
Lupus 0.6 1.0 3.4 1.0 0.2 1.0 0.0 1.3 0.9 0.5 0.0 1.7 -1.1 1.9 0.4 0.4 0.2 1.3 -0.2 0.9 1.3
Neuroticism (2016) 1.3 1.8 5.7 1.2 0.6 1.1 1.9 0.7 0.8 2.2 0.0 1.4 -1.6 1.6 0.6 0.4 1.8 0.8 0.3 1.7 2.4
Primary Biliary Cirrhosis 0.3 0.5 2.1 0.7 1.1 0.2 -0.3 -0.4 -0.2 -0.6 0.0 -0.4 -0.6 -0.1 1.4 1.4 0.6 0.5 0.6 0.6 0.2
Rheumatoid Arthritis 2.8 3.8 16.7 1.9 2.7 2.2 4.1 -0.2 3.0 1.7 0.0 0.9 -0.9 -0.5 1.0 0.2 3.2 -0.3 0.2 2.8 1.9
Schizophrenia (2014) 0.3 0.6 4.5 0.4 -0.5 0.8 -0.2 -0.3 0.7 -0.4 0.0 0.9 2.1 -0.3 -0.6 -0.3 -0.5 -0.4 -1.4 -0.3 -0.2
Triglycerides 0.3 0.4 1.6 -0.3 -1.3 -1.1 -0.5 0.7 0.2 0.6 0.0 0.4 -0.2 0.5 -0.4 -0.5 -0.9 0.5 -0.6 -0.9 -0.6
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.3 0.2 -1.0 -0.9 -1.3 0.9 -1.4 0.2 0.0 -0.0 -0.6 1.4 1.1 1.5 0.3 1.5 0.9 -0.2 0.4
Ulcerative Colitis 1.2 1.8 9.7 -0.9 -2.7 -3.1 -1.5 0.5 -2.1 0.5 0.0 -0.9 -0.4 0.9 -0.3 0.2 -1.2 0.1 1.2 -1.5 -0.5
Blood Eosinophil Count 0.1 0.5 3.2 -0.2 -0.4 1.3 -0.4 -0.4 0.8 -0.2 0.0 -0.3 1.8 -0.9 -0.7 -0.9 0.1 -0.8 -0.5 -0.6 -0.3
Blood Platelet Count 0.4 4.5 14.5 -2.3 0.0 -3.2 -1.3 0.2 -2.2 -3.8 0.0 -3.8 -0.3 -2.9 0.1 0.3 -1.6 -1.6 0.5 -1.8 -3.6
Blood Red Count 0.1 0.6 3.2 0.4 -1.8 -0.8 -0.1 1.2 0.4 0.7 0.0 0.2 -0.8 1.0 -0.8 0.3 0.9 1.0 -0.1 -1.1 -0.2
Blood White Count 0.7 5.2 10.6 -3.1 -2.0 -3.3 -3.0 -0.7 -2.5 -2.7 0.0 -2.5 2.0 -2.0 -1.3 -0.9 -3.1 -1.3 -0.7 -2.7 -3.2
Heel T-Score 2.2 17.6 66.9 2.7 -6.7 -3.8 -5.0 1.0 -7.2 2.8 0.0 4.4 1.9 8.2 0.1 2.1 -2.6 5.4 4.0 -2.4 3.6
BMI 0.3 1.9 4.5 -1.7 -1.1 -0.8 -0.3 -0.8 -0.1 -0.9 0.0 -1.5 2.1 -1.9 -1.4 -1.3 -0.8 -1.9 -1.9 -1.6 -1.9
Height 0.8 15.5 43.0 4.8 4.0 3.5 3.5 1.0 1.9 -0.5 0.0 1.4 -3.2 3.0 4.0 5.1 6.6 5.2 6.3 4.7 3.9
Waist Hip Ratio (WHR) 1.5 6.6 19.5 4.4 1.3 3.0 2.2 -0.5 2.5 3.2 0.0 3.5 -0.3 2.7 2.5 1.6 3.4 3.2 0.8 2.9 2.9
Systolic Blood Pressure 0.5 2.7 9.4 -1.8 1.9 -0.8 0.1 -0.7 -1.1 -2.9 0.0 -2.9 1.8 -3.1 0.4 -0.9 -0.5 -1.9 -0.4 -0.2 -2.3
Smoking Status 1.2 2.8 14.6 0.5 -0.7 -0.5 -1.1 2.1 -1.4 0.5 0.0 -0.5 -2.2 2.0 1.8 2.6 1.4 2.4 3.8 0.1 1.1
Allergy or Eczema 0.5 1.3 4.3 -0.8 0.9 -0.7 1.8 -1.2 1.3 1.3 0.0 -0.5 -1.5 -0.9 -0.1 -1.7 0.1 -2.1 -1.7 0.8 0.0
Cardiovascular Disease 0.3 1.1 6.7 1.0 0.4 -0.1 -0.2 0.4 -0.3 0.4 0.0 -0.1 -1.4 0.9 0.5 1.8 1.5 1.7 2.6 0.3 0.1
Hypothyroidism (self reported) 0.3 0.6 2.7 -0.5 -0.8 -0.2 -1.4 0.8 -1.6 -1.0 0.0 0.3 0.7 0.3 -0.4 0.1 -1.0 0.5 0.4 -1.0 -0.6
Respiratory disease 2.1 4.7 22.6 1.2 3.2 2.3 4.0 -0.6 4.8 1.4 0.0 0.7 -0.9 -0.1 0.8 -1.4 2.6 -0.7 -1.5 3.3 1.4
Type 2 Diabetes (T2D) (2018) 0.5 1.0 2.6 0.3 -1.1 -0.2 -1.6 1.5 -1.1 -0.4 0.0 0.8 -0.1 1.6 -0.6 0.8 -0.7 1.6 1.5 -0.7 0.4
Lung FEV1/FVC ratio 3.7 18.8 54.6 -2.5 -6.0 -5.8 -7.4 6.1 -6.7 -3.5 0.0 -3.1 -3.0 2.1 -0.6 4.0 -2.6 3.1 5.3 -5.1 -1.7
Lung FVC 3.0 15.5 40.4 4.9 1.7 3.7 3.5 1.2 2.3 6.4 0.0 4.6 -3.0 5.4 5.0 2.9 4.5 4.2 1.4 4.2 5.3
Neuroticism 0.9 2.2 8.0 1.5 0.3 1.1 1.0 0.5 1.2 2.8 0.0 2.1 -0.8 2.3 0.4 0.4 1.3 1.7 0.3 1.5 2.8
Chronotype (morning person) 1.9 4.4 11.8 2.1 1.5 1.0 1.8 0.9 0.8 2.3 0.0 1.4 -2.1 2.8 2.5 2.0 2.6 2.3 2.5 2.7 3.4
Hair Pigment 0.0 1.0 2.7 -1.1 -1.1 -0.6 -1.6 -0.7 -1.5 -1.1 0.0 -1.6 1.1 -0.7 -0.7 -0.5 -0.7 -0.8 0.9 -1.1 -0.8
Tanning 0.0 0.3 0.9 0.1 0.6 0.2 0.5 0.6 0.3 -0.4 0.0 -0.6 -0.3 -0.6 0.4 1.0 0.8 -0.2 0.3 0.2 -0.9
Hand grip strength (left) 1.0 2.6 9.9 -2.4 -0.7 -3.1 -1.0 0.6 -2.6 -1.8 0.0 -2.7 -0.8 -1.1 0.1 -0.1 -1.1 -1.4 1.2 -1.2 -1.8
Number of treatments/medications taken 0.1 0.1 0.6 0.4 -0.2 0.2 0.3 0.0 -0.3 0.8 0.0 0.2 0.7 0.5 -0.5 -0.2 0.2 0.4 0.4 -0.3 -0.0
Average weekly spirits intake 1.4 1.7 4.3 1.4 1.2 0.9 1.0 0.9 0.9 0.4 0.0 0.0 -1.4 1.0 1.6 1.8 2.1 1.2 1.8 1.6 2.0
Sensitivity / hurt feelings 0.6 1.0 3.5 0.6 -0.3 1.0 0.7 -0.8 1.5 1.3 0.0 1.8 0.5 0.8 -0.4 -1.0 -0.2 0.0 -1.9 1.0 1.4
Frequency of depressed mood in last 2 weeks 1.4 1.9 4.3 1.9 0.9 2.1 1.7 1.1 1.7 1.3 0.0 1.7 -0.6 1.3 0.7 0.8 2.0 1.8 0.5 1.5 1.4
Hearing difficulty/problems: Yes 1.6 2.5 7.2 -2.0 0.7 -0.3 -1.0 -1.7 -1.3 -2.1 0.0 -2.5 1.8 -2.7 -0.4 -1.4 -1.5 -2.1 -1.2 -0.8 -1.5
Relative age of first facial hair 0.8 1.6 4.8 0.7 1.5 2.2 1.8 -1.3 2.2 1.6 0.0 1.5 0.7 -0.0 -0.1 -1.0 0.4 -0.9 -1.9 1.3 -0.2
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 6.6 0.2 -0.2 -0.2 -0.3 -1.0 -0.2 0.4 0.0 0.7 1.6 -0.5 -0.9 -1.3 -1.1 -1.1 -2.6 -0.3 -0.2
Ever used hormone-replacement therapy (HRT) 2.7 3.5 11.7 -1.9 0.4 -0.8 0.4 -1.4 -0.3 -1.8 0.0 -1.6 1.7 -3.4 -1.9 -2.6 -1.8 -2.9 -2.3 -1.2 -2.6
Ever had hysterectomy (womb removed) 0.3 0.4 2.8 0.0 -0.0 0.1 0.0 0.1 -0.7 -0.8 0.0 -0.6 0.7 -0.8 -0.5 0.3 0.0 0.0 0.4 -0.7 -1.7
Systolic blood pressure, automated reading 1.0 2.9 9.7 -1.8 0.7 -0.4 0.3 -0.8 -0.3 -2.5 0.0 -2.4 2.9 -3.1 -0.3 -2.0 -1.2 -2.1 -1.6 -0.6 -2.1
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 2.7 1.1 1.1 1.6 1.1 -1.3 1.2 -1.0 0.0 0.0 0.9 -0.1 0.2 0.1 1.3 0.2 0.1 0.9 -0.0
Angina 1.1 1.4 4.8 -0.1 1.9 1.2 2.2 -1.5 1.7 0.1 0.0 -1.0 0.6 -0.6 0.6 -1.6 1.1 -0.9 -0.8 1.7 1.0
Medication for hormone replacement therapy 2.2 2.5 6.2 -2.4 -0.0 -1.1 -0.1 -0.5 -0.1 -1.7 0.0 -1.8 0.8 -2.4 -1.4 -2.5 -2.0 -2.5 -1.8 -0.9 -1.9
Vitamin and mineral supplements 0.6 0.8 2.8 0.4 -0.5 -1.3 -1.7 0.2 -1.4 -1.2 0.0 -1.0 0.2 -0.5 -0.3 0.7 -0.2 0.4 1.5 -1.2 0.1
Supplements: Zinc 0.6 0.6 3.0 -0.3 -0.1 1.7 0.8 0.4 1.0 -0.3 0.0 0.7 1.0 -0.3 -0.2 -0.8 -0.2 -0.7 -1.7 0.4 -0.1
Medication: Co-codamol 0.6 0.7 1.7 -1.2 -0.9 -1.1 -0.8 0.4 -0.7 -0.1 0.0 -0.2 0.1 -0.6 -1.2 -1.0 -1.3 -0.6 -0.5 -1.2 -0.9
Medication: Metformin 0.6 0.8 4.0 1.0 -0.1 0.2 -0.7 1.6 -0.2 -0.8 0.0 0.4 -0.1 1.0 0.4 1.3 0.6 2.0 1.5 0.0 0.4
Diabetes (father) 0.6 0.8 3.0 -0.8 -1.3 -0.6 -1.7 0.8 -0.3 0.0 0.0 0.4 0.6 0.0 -1.2 -0.8 -1.4 -0.3 -1.2 -1.2 -0.2
Diabetes (mother) 0.7 0.9 2.4 1.2 -0.7 0.6 0.3 0.8 1.4 0.9 0.0 1.6 0.8 1.4 -0.9 0.5 0.4 1.5 0.5 0.2 1.2
Severe depression (siblings) 1.6 1.8 6.9 -0.4 -0.7 -0.5 -1.5 2.3 -2.0 -0.8 0.0 -1.4 -1.4 1.0 1.3 1.8 0.0 1.7 2.6 -0.3 -0.4
Pack years adult smoking proportion 0.1 0.2 0.7 -0.1 0.6 -0.5 -0.1 0.5 -0.6 0.1 0.0 -0.1 -0.7 -0.0 -0.3 0.8 0.1 0.4 0.4 -0.2 -0.3
Impedance of leg (right) 0.4 2.0 7.6 -0.2 2.1 0.0 2.1 -2.8 2.4 0.3 0.0 0.1 0.4 -1.5 0.3 -1.6 0.2 -1.9 -1.6 1.5 0.4
Leg fat-free mass (left) 0.7 3.4 11.3 1.7 0.2 1.0 0.4 2.4 -0.1 -0.4 0.0 0.2 -1.9 2.0 1.8 3.4 3.0 3.0 2.9 1.0 1.6
Trunk fat percentage 0.1 0.4 1.4 0.8 -0.8 0.8 -0.0 -0.5 -0.1 0.1 0.0 1.2 1.1 0.7 0.1 0.7 0.3 0.6 -0.6 0.1 0.2
Hand grip strength (right) 0.5 1.2 4.9 -1.1 0.0 -1.8 -0.6 0.6 -2.0 -1.2 0.0 -1.7 -1.0 -0.3 1.1 1.1 0.1 -0.3 2.2 -0.2 -0.7
Townsend deprivation index at recruitment 0.7 1.0 3.2 1.5 1.7 0.8 0.6 0.5 0.4 -0.2 0.0 0.3 -0.5 0.1 1.5 1.8 1.6 1.4 0.8 0.6 -0.2
Current tobacco smoking 0.3 0.5 2.9 -0.8 -0.5 -1.0 -0.8 0.9 -0.5 0.2 0.0 -0.9 -0.9 0.3 -0.4 0.2 0.0 0.3 1.7 -0.3 0.3
Average weekly fortified wine intake 1.0 1.2 3.2 -1.8 -0.5 -0.9 -1.3 0.3 -1.4 -1.1 0.0 -1.6 0.0 -1.2 -1.2 -0.9 -1.5 -1.3 -0.2 -1.3 -0.8
Maternal smoking around birth 0.7 1.0 2.8 1.7 0.4 0.9 0.2 0.9 0.7 1.0 0.0 0.8 -0.6 0.9 1.3 1.5 1.5 1.6 1.0 0.7 1.0
Fed-up feelings 1.0 1.8 6.0 1.4 -0.2 1.5 1.8 0.1 2.0 2.5 0.0 2.3 0.0 1.3 -0.4 -0.2 1.1 0.6 -1.0 1.5 1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 5.3 1.3 -0.1 2.1 0.7 0.5 1.3 1.4 0.0 2.3 0.9 1.3 -0.6 -0.1 0.6 1.2 -0.6 0.7 1.4
Relative age voice broke 3.1 4.7 13.0 2.5 3.2 2.7 3.1 -0.5 3.4 1.9 0.0 2.2 -1.4 1.4 1.9 0.4 2.5 0.7 0.2 3.6 2.0
Taking other prescription medications 0.1 0.2 1.8 0.7 -0.3 0.5 -0.4 0.2 -0.4 -0.1 0.0 -0.1 1.3 0.1 -0.6 -0.0 0.1 0.3 0.2 -0.6 -0.1
Age when periods started (menarche) 0.4 1.1 4.5 0.5 -2.1 -0.3 -0.1 -0.1 0.2 0.3 0.0 2.1 1.4 0.7 -1.5 -1.3 -1.4 0.5 -0.7 -0.4 0.9
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.5 0.8 0.7 -0.6 0.8 0.8 0.1 -1.1 0.0 -0.7 -0.0 -0.8 0.8 1.1 1.2 0.3 0.6 0.3 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 2.9 6.5 24.4 2.1 -3.9 -1.9 -3.1 1.8 -3.3 1.1 0.0 2.6 -0.3 4.9 0.8 2.5 -0.5 4.1 3.0 -1.2 2.2
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 4.5 2.0 -0.1 1.7 1.3 1.1 0.3 1.3 0.0 1.9 -1.6 2.1 0.9 1.0 1.5 1.8 1.1 1.7 2.1
Qualifications: CSEs or equivalent 3.0 3.9 9.9 -1.3 -3.1 -2.7 -3.1 2.7 -2.7 -0.5 0.0 -1.5 -2.3 1.6 -0.0 2.0 -0.9 1.6 2.0 -2.0 -1.2
Serious illness, injury or assault to yourself 1.3 1.5 4.7 1.2 -0.5 -0.1 1.3 -1.3 1.7 2.0 0.0 2.2 0.9 0.6 -0.9 -1.3 0.3 -0.7 -1.8 0.7 1.7
High blood pressure 1.0 2.7 6.4 2.4 0.8 0.9 0.6 1.5 0.0 1.9 0.0 1.2 -1.8 2.0 1.7 2.3 2.2 2.5 2.0 0.9 1.4
Hayfever, allergic rhinitis or eczema 0.5 1.0 3.0 -0.6 1.0 0.0 1.5 -1.4 1.7 0.8 0.0 -0.5 -0.8 -0.8 0.2 -1.1 0.3 -1.6 -1.5 1.1 0.1
Multivitamins +/- minerals 0.5 0.7 2.4 -0.4 -0.3 0.3 -0.1 1.6 0.1 0.3 0.0 0.2 -1.4 1.2 1.4 1.2 0.3 1.1 0.7 0.5 -0.1
Stomach or abdominal pain in last month 0.5 0.7 2.8 0.9 0.9 1.0 1.7 -1.0 1.1 0.4 0.0 1.0 0.3 0.1 0.6 0.3 1.0 0.4 0.0 1.2 0.6
Supplements: Glucosamine 3.2 4.2 8.3 2.9 0.7 2.9 1.6 0.6 1.0 1.8 0.0 2.4 -0.2 2.9 2.0 2.1 2.6 2.7 1.9 1.9 2.6
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 1.5 -0.6 1.2 0.6 0.7 0.4 0.4 -0.2 0.0 -0.7 -0.2 -0.8 -0.1 -0.7 -0.1 -1.0 -0.4 0.5 -0.4
Medication: Atenolol 1.0 1.3 3.5 -0.8 1.6 0.1 0.7 -1.9 0.6 -1.7 0.0 -1.9 1.3 -1.7 -0.5 -0.1 0.6 -1.4 -0.2 0.1 -1.5
Medication: Levothyroxine sodium 1.0 1.8 6.1 1.3 -0.0 1.0 -0.8 2.1 -1.1 0.3 0.0 0.8 -0.7 2.1 1.4 2.2 1.0 2.5 1.8 0.4 0.6
Sitting height 0.5 3.6 31.7 -1.3 0.6 -0.3 -1.6 2.0 -0.4 -5.6 0.0 -2.9 0.1 -2.5 -1.1 1.1 0.1 0.0 2.0 -1.0 -1.2
Chronic bronchitis/emphysema (father) 0.2 0.3 0.7 0.8 -0.1 0.2 0.2 0.8 0.0 0.4 0.0 0.6 -0.1 0.7 0.8 0.7 0.6 0.8 0.0 0.5 0.3
High blood pressure (mother) 0.3 0.5 1.4 0.3 -0.5 -0.9 -0.3 0.7 0.4 1.0 0.0 0.7 -1.2 1.1 -0.6 0.4 0.2 0.8 0.8 -0.2 1.0
Body mass index (BMI) 0.0 0.2 1.0 -0.1 -0.6 -0.0 -0.0 -0.0 -0.0 -0.3 0.0 -0.1 1.0 -0.3 -0.6 -0.0 -0.0 -0.3 -0.9 -0.5 -0.6
Impedance of leg (left) 0.4 2.1 7.3 0.1 2.0 0.4 2.2 -2.7 2.5 0.7 0.0 0.7 0.6 -1.2 0.3 -1.7 0.3 -1.7 -1.8 1.8 0.7
Leg predicted mass (left) 0.6 3.4 10.8 1.7 0.2 1.1 0.4 2.4 -0.1 -0.3 0.0 0.2 -1.9 2.0 1.7 3.3 3.0 3.0 2.8 1.0 1.6
Trunk fat mass 0.1 0.5 2.3 1.0 -0.5 0.7 0.1 0.4 -0.1 -0.4 0.0 0.7 0.5 0.8 0.5 1.5 1.1 1.3 0.5 0.2 0.4
Waist circumference 0.2 0.9 2.2 1.5 0.3 1.5 1.2 -1.2 1.3 0.5 0.0 1.2 1.2 0.2 0.6 0.5 1.4 0.7 -0.6 0.8 0.5
Number of incorrect matches in round 0.5 0.8 3.2 -0.9 -1.5 -1.8 -1.0 -0.3 -1.0 0.1 0.0 -0.3 0.3 -0.2 -0.6 -0.7 -1.4 -0.5 -0.4 -1.5 -0.9
Past tobacco smoking 1.4 2.5 9.6 -0.6 -0.0 0.3 -0.3 -2.1 1.0 -0.7 0.0 0.6 3.1 -1.6 -2.2 -2.4 -1.8 -1.8 -2.8 -0.6 -0.6
Alcohol usually taken with meals 2.7 4.4 8.9 -3.0 -0.7 -2.2 -1.7 -0.8 -1.3 -3.0 0.0 -2.9 1.1 -3.0 -2.0 -1.5 -2.5 -2.5 -1.1 -2.5 -2.5
Nervous feelings 0.7 1.3 5.3 0.5 0.2 0.7 1.0 -0.3 1.9 2.0 0.0 1.4 -0.6 1.5 -0.0 -1.2 0.6 0.5 -0.1 1.4 2.3
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 2.7 0.8 0.9 1.6 1.6 -0.0 1.6 0.7 0.0 0.3 -0.2 0.2 0.2 -0.2 1.3 0.2 -1.0 1.3 0.7
Hearing difficulty/problems with background noise 0.1 0.2 1.0 0.3 0.4 0.8 -0.4 -0.0 -0.4 -0.4 0.0 0.0 1.0 -0.6 0.3 -0.1 -0.4 0.1 -0.7 -0.2 -0.5
Hair/balding pattern: Pattern 2 0.6 0.8 3.6 0.6 1.1 0.4 1.3 -1.5 0.5 1.9 0.0 0.7 0.0 0.6 1.1 -0.1 0.8 0.1 -0.4 1.2 0.4
Had menopause 0.4 0.5 1.8 -0.3 -0.3 0.2 -0.8 -0.7 -1.3 -0.8 0.0 -0.0 0.9 -0.3 -0.1 -1.1 -1.3 -0.5 -0.7 -0.3 -0.4
Had other major operations 0.8 0.9 3.6 1.6 0.8 1.4 0.6 -1.2 0.2 1.1 0.0 1.9 1.1 0.7 0.4 0.2 0.4 0.8 -0.7 0.5 1.3
Forced vital capacity (FVC) 4.2 16.0 27.5 4.7 2.1 2.5 3.2 2.5 1.9 5.0 0.0 4.0 -4.7 5.2 4.6 4.0 5.1 4.8 3.6 4.4 5.0
Heel bone mineral density (BMD) T-score, automated (right) 3.1 7.0 27.2 2.3 -3.8 -2.2 -3.0 1.8 -3.6 1.7 0.0 3.1 -0.4 5.2 0.4 2.4 -0.8 4.1 2.8 -1.2 1.9
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.8 -1.3 -1.1 -0.6 -1.0 0.3 -1.7 -0.2 0.0 -1.4 -0.1 0.3 -0.5 0.4 0.1 -0.1 1.1 -1.1 0.4
Qualifications: None of the above 2.6 5.6 13.8 3.5 0.3 1.7 1.4 2.4 1.9 1.9 0.0 2.9 -1.5 3.0 1.5 2.6 2.8 3.7 2.6 2.0 3.1
Financial difficulties in last 2 years 0.5 0.7 2.7 1.0 -0.1 0.3 0.5 0.5 0.8 1.3 0.0 1.6 0.3 1.3 0.3 0.2 0.6 1.1 -0.1 0.6 1.2
Mouth/teeth dental problems 2.0 3.0 8.9 -3.0 -1.9 -2.7 -2.2 0.3 -1.9 -0.7 0.0 -2.3 0.2 -1.2 -1.0 -0.8 -2.0 -1.8 -0.7 -2.5 -1.8
Heart attack 0.5 0.7 3.0 1.1 1.7 0.7 1.2 -1.1 0.4 -1.4 0.0 -0.5 0.4 -0.8 0.5 0.1 0.9 -0.2 -0.0 1.1 0.4
Allergy 0.9 2.0 6.8 -0.4 -2.1 -1.4 -2.6 1.4 -2.6 -1.0 0.0 -0.1 0.9 0.1 -0.8 1.0 -1.4 1.0 1.0 -2.2 -1.0
Pain all over the body in last month 1.2 1.3 3.0 -1.3 -0.9 -0.3 -1.5 0.9 0.1 -1.6 0.0 -0.6 0.7 -1.0 -1.7 -1.0 -1.7 -0.7 -1.4 -1.4 -1.4
Diabetes (self-reported) 1.1 1.7 7.9 1.5 -0.4 0.9 -0.9 1.6 -0.4 -0.2 0.0 1.0 -1.1 2.0 0.9 1.8 0.8 2.8 1.9 0.4 0.8
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.6 -0.5 -0.0 -0.0 0.7 -1.2 1.3 0.9 0.0 -0.3 -0.4 -0.6 -0.2 -0.5 0.2 -0.9 -0.9 0.1 0.2
Medication: Ramipril 0.3 0.3 0.9 -0.1 -0.2 -0.8 -0.6 0.0 -0.9 -1.0 0.0 -0.6 0.9 -0.5 -0.1 0.5 -0.5 -0.5 0.4 -0.9 -0.4
Medication: Simvastatin 0.7 1.1 3.4 0.9 1.4 0.6 0.2 0.4 0.1 -1.0 0.0 -0.7 -1.1 0.1 1.1 1.4 1.4 1.1 1.8 1.0 1.2
Fluid intelligence score 0.6 1.2 5.5 -1.1 -0.0 -0.5 0.3 -1.6 0.6 -0.1 0.0 -0.3 0.3 -1.3 -0.7 -2.0 -0.9 -2.2 -2.3 -0.4 0.0
Illnesses of siblings 0.8 1.2 3.8 -1.3 -0.9 -1.2 -0.8 -0.2 -0.4 -0.0 0.0 -0.0 0.2 -1.0 -1.8 -1.4 -1.3 -1.5 -1.9 -1.2 -0.9
Neuroticism score 1.0 2.2 8.5 1.3 0.2 1.3 1.5 0.2 1.5 2.9 0.0 2.3 -0.7 2.0 -0.3 -0.1 1.2 1.2 0.0 1.6 2.7
Weight 0.2 1.1 4.3 1.3 0.3 0.8 0.8 0.8 0.4 -0.5 0.0 0.3 -0.4 0.8 1.0 1.9 2.1 1.6 1.3 0.7 0.9
Impedance of arm (right) 0.4 1.7 7.5 1.4 -1.4 0.6 -0.6 -0.4 -0.8 1.8 0.0 2.7 -0.5 2.7 0.6 0.9 -0.1 1.8 0.8 0.5 1.4
Arm fat percentage (right) 0.1 0.4 1.7 0.4 -1.3 0.3 -0.8 0.3 -0.8 -0.2 0.0 0.8 0.9 0.6 -0.3 0.8 -0.2 0.7 -0.4 -0.6 -0.5
Trunk fat-free mass 0.6 3.4 10.4 1.4 1.6 0.4 0.9 2.2 0.7 -1.5 0.0 -0.8 -2.1 0.7 1.9 3.1 3.2 2.4 3.2 1.3 1.3
Hip circumference 0.1 0.2 1.1 0.0 0.4 0.5 0.5 -0.5 0.5 -1.0 0.0 -0.5 0.6 -0.4 0.3 0.6 1.1 -0.0 -0.2 0.3 0.2
Time employed in main current job 0.9 1.0 4.1 -0.1 -0.1 0.2 -0.4 -1.5 -0.6 -1.6 0.0 0.3 2.0 -1.0 -1.0 -1.5 -1.6 -1.0 -0.9 -0.5 -0.5
Alcohol intake versus 10 years previously 1.8 2.7 8.1 2.3 1.6 2.0 2.8 -0.6 1.5 1.5 0.0 1.9 -1.1 1.3 1.4 1.5 2.9 1.2 0.6 2.1 0.9
Father’s age at death 3.3 4.4 12.5 -3.1 -1.8 -2.9 -2.6 1.9 -3.5 -1.7 0.0 -2.7 -0.3 -1.6 -1.2 -0.9 -2.6 -1.7 -0.1 -2.5 -2.0
Worrier / anxious feelings 1.7 3.2 9.2 2.2 0.7 1.5 2.0 -0.2 1.9 2.6 0.0 2.5 -1.2 2.3 0.4 0.3 2.1 1.6 0.6 2.2 3.0
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 3.6 0.5 0.8 1.5 1.8 -0.2 1.9 1.2 0.0 0.9 -0.3 0.2 0.4 -0.9 1.0 -0.0 -1.5 1.6 0.8
Falls in the last year 0.6 0.8 2.2 1.1 1.3 1.3 1.2 -0.1 1.0 0.2 0.0 0.7 -0.1 0.4 1.1 0.5 0.8 0.7 -0.4 1.5 0.8
Hair/balding pattern: Pattern 3 0.4 0.7 1.8 -0.8 -0.2 0.3 0.1 -0.9 0.4 -1.3 0.0 -1.3 0.5 -1.2 -1.3 -0.6 -0.4 -1.1 -0.1 -0.4 -1.1
Number of live births 1.2 1.6 6.0 -0.8 -0.2 0.6 -0.2 -1.8 0.5 -0.9 0.0 0.3 2.5 -1.2 -1.7 -1.9 -1.4 -1.6 -2.2 -0.6 -0.7
Forced expiratory volume in 1-second (FEV1) 4.0 13.4 29.5 3.6 -0.0 0.4 0.8 3.9 -0.3 3.7 0.0 2.6 -5.2 5.4 4.1 5.1 4.0 5.3 4.9 2.5 4.0
Pulse rate 0.9 1.5 7.5 -0.9 -1.5 -1.4 -1.4 2.7 -1.9 0.2 0.0 -0.9 -1.2 0.4 0.3 1.0 -0.3 1.1 1.5 -1.3 -0.4
Happiness 0.7 0.8 3.9 0.6 -0.8 -0.0 0.1 -0.6 0.5 -0.1 0.0 0.5 1.6 -1.0 -2.0 -0.9 -0.2 -0.7 -1.7 -1.2 -0.0
Noisy workplace 0.4 0.5 3.9 0.5 -0.3 0.1 -0.6 0.5 0.3 -0.6 0.0 0.2 -0.5 0.8 -0.9 0.7 0.1 1.2 2.0 0.0 0.2
Qualifications: A levels/AS levels or equivalent 1.6 3.5 8.9 -2.5 -1.0 -1.9 -0.6 -1.2 -0.0 -1.0 0.0 -1.8 1.4 -2.1 -2.9 -2.9 -2.0 -3.0 -1.9 -1.6 -1.8
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.4 -1.5 0.2 -0.8 -0.0 -0.6 0.3 0.2 0.0 -1.3 -0.1 -0.7 -0.1 -1.5 -1.0 -1.5 -1.2 0.4 0.1
Mouth/teeth dental problems: Dentures 1.2 2.0 7.5 2.1 2.7 2.3 2.3 -0.8 1.6 -0.5 0.0 1.2 0.4 -0.7 0.8 0.2 1.7 0.3 -0.0 2.0 0.3
Asthma 1.5 3.1 12.8 1.3 2.0 2.1 3.3 -0.8 3.6 1.1 0.0 1.1 -0.7 0.4 0.4 -1.1 1.9 -0.5 -1.7 2.7 1.3
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.1 5.3 -2.1 -2.1 -2.3 -2.2 0.2 -1.0 -1.0 0.0 -1.4 0.9 -0.4 -1.4 -0.9 -1.9 -0.5 -1.0 -2.1 -1.0
Medication: Cholesterol lowering 0.4 0.6 2.4 0.1 1.2 0.2 0.0 0.7 -0.4 -0.4 0.0 -1.1 -0.8 0.2 1.2 1.0 1.0 0.6 1.6 0.5 0.6
Depression (self-reported) 0.6 0.7 3.0 1.0 0.9 1.7 0.9 0.1 0.8 1.4 0.0 1.0 0.5 0.9 0.4 0.0 0.5 0.7 -0.2 0.9 0.8
Medication: Lansoprazole 1.2 1.3 5.7 0.4 0.2 0.2 -0.5 1.1 -1.2 0.2 0.0 -0.2 -1.2 1.5 1.5 1.9 1.1 1.8 2.4 0.6 1.1
Prospective memory result 0.7 0.9 2.9 1.2 0.4 0.8 -0.3 1.1 0.2 0.6 0.0 1.0 -0.7 1.7 1.1 1.4 0.7 1.7 0.5 0.8 0.7
Lung cancer (father) 0.2 0.3 1.3 0.5 0.5 0.0 0.9 -0.5 1.1 -0.4 0.0 0.2 1.1 -0.6 -0.5 -0.1 0.3 -0.3 0.1 0.3 -0.3
Illnesses of mother 0.6 0.8 2.7 -1.4 -0.3 -0.9 -0.1 -0.5 -0.3 -1.0 0.0 -1.2 0.2 -1.2 -0.1 -1.0 -0.8 -1.6 -0.8 -0.4 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 4.8 15.4 32.3 4.0 0.2 1.2 1.1 3.9 0.0 3.7 0.0 2.8 -5.2 5.7 4.5 5.6 4.6 5.7 5.7 2.8 4.0
Pulse wave Arterial Stiffness index 0.3 0.3 1.1 0.6 0.5 0.3 0.9 -0.1 1.1 0.7 0.0 0.9 -0.4 0.5 -0.5 -0.3 0.7 0.4 0.1 0.0 0.6
Impedance of arm (left) 0.4 1.8 7.8 1.6 -1.3 0.9 -0.3 -0.7 -0.4 2.2 0.0 2.6 -0.5 2.8 0.7 0.9 0.2 1.8 0.7 0.7 1.4
Arm fat mass (right) 0.1 0.5 2.5 0.8 -0.6 0.5 -0.1 0.6 -0.3 -0.4 0.0 0.5 0.4 0.8 0.4 1.6 1.0 1.2 0.5 -0.0 0.2
Trunk predicted mass 0.6 3.5 10.6 1.4 1.5 0.4 0.9 2.3 0.7 -1.5 0.0 -0.7 -2.1 0.8 1.8 3.1 3.2 2.5 3.3 1.2 1.4
Standing height 0.9 9.0 26.5 3.0 1.7 1.5 1.7 2.0 0.9 -0.0 0.0 1.1 -3.3 2.9 3.3 4.5 4.7 4.4 5.2 2.8 3.5
Length of working week for main job 1.6 1.8 4.6 1.6 1.3 1.0 1.5 0.8 0.4 1.3 0.0 1.0 -1.7 0.9 2.2 1.4 1.9 1.3 0.7 1.9 1.3
Exposure to tobacco smoke at home 0.3 0.3 1.5 -0.0 1.2 0.2 0.5 -1.2 0.1 -0.3 0.0 -0.4 0.5 -0.8 0.4 -0.1 0.5 -0.7 -0.2 0.3 0.6
Breastfed as a baby 1.0 1.3 5.5 -1.6 -0.6 -1.2 -1.0 -0.6 -1.6 -0.3 0.0 -0.6 0.7 -0.8 -0.5 -1.7 -2.4 -1.5 -0.8 -0.8 -0.9
Tense / ‘highly strung’ 0.5 0.9 4.0 0.8 0.5 1.0 1.1 -0.5 1.3 2.0 0.0 1.3 -0.2 1.0 0.3 -0.1 0.9 0.7 -0.2 1.2 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 6.6 0.3 -0.9 0.8 0.7 -0.6 1.4 2.6 0.0 1.6 0.9 0.9 -1.8 -1.6 -0.5 -0.1 -1.0 0.1 0.2
Hair/balding pattern: Pattern 4 0.4 0.9 4.6 -0.8 0.2 -0.4 -2.1 1.2 -2.0 -1.0 0.0 -0.7 -0.1 -0.1 0.1 -0.2 -1.6 -0.1 -0.3 -0.6 0.7
Birth weight of first child 0.8 1.4 6.4 -0.2 -1.1 -0.6 -1.9 2.5 -1.7 -1.5 0.0 0.2 -1.1 0.7 -0.1 1.6 -0.6 1.4 1.2 -0.9 -0.0
Peak expiratory flow (PEF) 0.4 1.0 3.5 0.5 -1.0 -1.1 -0.4 0.8 -1.3 1.3 0.0 0.9 -1.4 1.9 0.4 1.3 0.2 1.2 1.0 -0.0 0.8
Pulse wave reflection index 0.5 0.6 2.2 0.7 1.0 1.0 1.2 -0.2 1.5 -0.2 0.0 0.4 -0.8 0.4 0.2 0.4 1.3 0.4 0.3 0.8 0.5
Ever highly irritable/argumentative for 2 days 1.6 2.0 4.7 1.5 1.1 1.5 1.0 0.7 0.8 1.0 0.0 0.9 -1.7 1.4 1.5 1.6 2.2 2.0 1.6 1.5 1.6
Loud music exposure frequency 0.6 0.7 1.7 -0.8 -1.0 -0.8 -0.7 -0.7 -0.4 -0.1 0.0 -0.4 1.3 -0.8 -0.9 -0.7 -1.2 -0.8 -1.2 -0.8 -0.6
Qualifications: O levels/GCSEs or equivalent 1.1 1.8 5.7 -2.1 -0.1 -0.9 -0.9 -0.7 -0.8 -1.5 0.0 -2.2 -0.0 -2.0 -0.7 -0.7 -1.0 -2.4 -1.1 -0.9 -1.8
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 2.0 1.1 -0.8 -0.4 0.1 0.5 0.6 0.8 0.0 1.2 -0.1 1.1 -0.4 0.0 0.0 1.3 0.6 0.3 1.4
Blood clot in the leg (DVT) 2.2 2.9 9.1 2.5 1.4 2.1 1.1 -0.2 -0.0 1.1 0.0 1.3 -0.9 1.6 3.0 1.9 2.0 2.1 1.1 2.2 2.0
Medication: Paracetamol 0.3 0.5 2.0 -0.7 -1.0 -1.4 -0.1 1.1 -0.4 0.3 0.0 -0.7 -0.7 0.2 -1.1 -0.0 0.1 -0.0 0.5 -0.8 -0.5
Headache pain in last month 0.7 1.1 3.7 0.2 -1.6 -0.8 0.4 1.5 0.6 1.3 0.0 1.5 0.3 0.6 -1.9 -1.7 -0.6 0.1 -1.1 -0.7 1.1
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 3.2 0.1 -0.6 -0.1 0.5 -1.5 0.8 -0.0 0.0 1.2 1.7 -0.5 -0.8 -1.4 -1.0 -0.9 -1.8 -0.1 -0.3
Glaucoma (self-reported) 1.0 1.1 4.2 0.9 1.1 0.5 0.3 1.2 -0.3 -0.2 0.0 -0.2 -1.4 0.8 0.9 2.0 1.7 1.0 2.1 0.7 0.9
Gout (self-reported) 0.8 1.1 3.6 -0.5 1.5 0.2 0.8 -1.2 0.6 -0.8 0.0 -1.2 1.8 -1.9 0.1 -0.9 0.2 -1.4 -1.5 0.1 -0.7
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 1.9 0.5 -0.2 0.8 -0.4 0.9 -0.6 0.5 0.0 1.4 0.3 1.3 0.3 0.3 -0.3 1.1 0.5 0.1 0.6
Medication: Amlodipine 1.1 1.6 4.7 0.9 -1.2 -0.5 -1.9 1.4 -1.2 0.5 0.0 0.6 -1.6 1.8 0.4 1.7 0.3 2.2 1.8 -0.7 0.8
Medication: Ventolin 100micrograms inhaler 1.0 1.3 5.2 0.5 0.9 0.8 1.3 -1.4 2.3 -0.0 0.0 0.6 1.6 -0.8 -0.7 -1.6 0.0 -1.3 -2.1 0.9 -0.0
Birth weight 1.0 2.3 10.7 0.5 -1.7 -0.7 -2.5 1.6 -3.3 -1.6 0.0 -0.3 0.3 0.6 0.7 2.3 -0.4 1.6 2.1 -1.4 -0.2
Chronic bronchitis/emphysema (mother) 0.4 0.5 2.6 0.2 0.6 0.9 0.0 1.6 0.1 -0.1 0.0 -0.1 -0.3 0.9 0.4 0.5 0.6 0.9 1.4 0.8 0.6
High blood pressure (siblings) 0.6 0.9 2.1 0.8 0.4 1.1 1.5 0.6 0.6 1.0 0.0 0.4 -1.0 1.2 0.6 0.3 1.2 1.0 1.4 1.4 0.9
Forced vital capacity (FVC), Best measure 5.0 18.4 31.9 5.2 2.3 3.4 3.3 2.5 2.2 4.9 0.0 4.0 -4.6 5.5 5.1 4.7 5.6 5.2 4.5 4.7 5.2
Body fat percentage 0.1 0.3 1.7 0.5 -0.6 0.6 0.2 -0.6 0.1 -0.2 0.0 0.7 1.3 0.0 -0.2 0.2 0.2 0.0 -0.9 -0.0 -0.2
Leg fat percentage (right) 0.4 1.5 4.4 -0.5 0.8 -0.1 1.3 -1.4 1.1 -1.1 0.0 -0.6 1.9 -2.1 -0.7 -1.4 -0.3 -1.9 -2.1 0.1 -1.1
Arm fat-free mass (right) 0.4 2.1 8.9 1.3 1.5 0.9 1.5 1.3 1.4 -1.1 0.0 -0.5 -0.9 0.2 1.6 2.1 3.0 1.6 1.9 1.3 1.2
Exposure to tobacco smoke outside home 0.7 1.0 3.2 0.7 0.1 1.4 1.4 0.3 1.2 1.8 0.0 1.2 -0.6 0.9 0.5 -0.3 1.0 0.1 -1.3 0.7 1.6
Comparative body size at age 10 0.3 0.8 2.3 -0.3 1.2 1.2 1.4 -0.4 0.8 1.5 0.0 0.2 0.1 0.4 0.7 -0.6 0.9 -0.5 -0.6 1.3 1.3
Number of full brothers 0.1 0.2 1.5 -0.2 -1.2 -0.2 -0.5 -0.4 0.1 0.2 0.0 -0.5 0.6 0.0 0.2 0.2 0.2 0.3 -0.2 -0.5 -0.3
Worry too long after embarrassment 0.6 1.0 4.7 0.1 -1.2 -0.3 -1.0 0.8 -0.4 1.5 0.0 0.3 -1.4 2.2 -0.1 0.7 0.5 1.2 0.5 -0.2 1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 4.9 1.1 -0.0 1.3 1.4 1.3 1.6 2.2 0.0 1.8 -0.6 1.3 -0.4 -0.4 0.6 0.4 -0.0 1.2 1.9
Wheeze or whistling in the chest in last year 1.2 2.2 6.4 -0.3 1.1 1.0 2.5 -2.2 2.4 1.0 0.0 0.3 1.1 -1.3 -0.6 -2.5 0.2 -1.9 -2.1 1.1 0.3
Number of children fathered 1.2 1.3 5.3 -0.8 -1.7 -0.3 -1.9 0.6 -0.7 -1.1 0.0 0.7 1.1 -0.5 -1.7 -0.6 -2.3 -0.3 -0.0 -1.6 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 2.2 -0.0 -0.1 0.3 0.4 -0.4 1.5 1.1 0.0 0.1 -1.0 0.3 0.2 -0.0 0.2 -0.4 -0.2 0.4 -0.4
Age at first live birth 1.0 1.8 5.5 -2.3 -0.9 -1.3 -0.4 -1.2 0.3 0.1 0.0 -0.7 1.2 -1.0 -1.7 -2.2 -1.7 -2.1 -1.4 -1.2 -0.9
Pulse wave peak to peak time 0.2 0.2 0.9 -0.2 -0.3 -0.2 -0.6 0.0 -0.9 -0.5 0.0 -0.7 0.1 -0.2 0.8 0.7 -0.2 -0.1 0.3 0.2 -0.3
Health satisfaction 1.2 1.5 4.6 0.7 -1.1 -0.2 0.7 -0.8 1.4 1.9 0.0 2.1 0.9 0.7 -2.0 -1.9 -0.7 -0.5 -1.6 -0.2 1.4
Shortness of breath walking on level ground 1.0 1.2 2.7 0.8 1.1 1.0 1.4 -1.6 1.5 0.9 0.0 1.2 1.2 0.4 -0.6 -1.5 0.1 -0.7 -1.4 1.4 1.0
Qualifications: College or University degree 0.8 2.5 11.3 -1.4 1.5 0.3 1.5 -2.5 0.6 0.4 0.0 -0.9 0.5 -1.8 -0.8 -2.8 -0.7 -3.4 -2.5 0.7 -0.5
Eye problems/disorders: None of the above 0.8 0.9 2.7 -1.6 0.2 -0.3 -0.4 -0.9 0.0 -1.1 0.0 -1.5 0.6 -1.7 -0.2 -0.9 -0.9 -1.4 -0.8 -0.6 -1.4
Mouth/teeth dental problems: Loose teeth 0.8 1.0 3.3 1.0 -0.5 -0.8 -0.3 0.4 -0.6 0.0 0.0 0.4 -0.8 1.6 1.2 1.6 0.6 1.8 1.8 0.1 0.7
Emphysema/chronic bronchitis 0.3 0.4 1.3 -1.0 0.3 0.3 -0.2 -0.3 0.2 -0.9 0.0 -1.1 1.0 -0.9 -0.1 -0.8 -0.6 -0.5 0.1 0.1 -0.0
Medication for pain relief, constipation, heartburn 0.3 0.6 2.1 -0.0 1.3 1.2 0.6 -1.0 0.5 -0.8 0.0 0.1 0.6 -1.4 0.5 -0.2 -0.0 -1.1 -0.9 0.5 -0.7
Neck or shoulder pain in last month 0.1 0.1 0.8 0.3 0.6 -0.1 0.5 0.4 -0.2 -0.2 0.0 0.1 0.9 -0.0 0.1 -0.2 0.3 0.5 0.0 0.2 0.3
Medication: Blood pressure 0.7 1.3 5.7 -0.1 -0.5 -0.4 -0.9 2.4 -1.1 0.9 0.0 -0.6 -2.1 1.2 0.7 1.5 0.6 1.4 1.6 -0.2 0.3
Angina (self-reported) 1.0 1.3 3.6 -0.2 1.8 0.9 1.9 -1.6 1.4 0.0 0.0 -1.1 1.0 -0.8 0.5 -1.8 0.8 -1.2 -1.0 1.4 0.8
Migraine (self-reported) 1.2 1.5 4.3 -0.8 -2.1 -1.2 -1.6 1.0 -0.2 -1.5 0.0 -0.5 1.1 -0.7 -2.0 -0.9 -1.6 -0.2 -0.5 -1.8 -1.6
Medication: Ibuprofen 1.9 2.3 5.5 -1.9 -2.2 -2.4 -2.1 0.0 -1.1 -0.6 0.0 -0.9 1.4 -0.7 -1.5 -1.0 -2.2 -0.8 -1.3 -2.3 -1.6
Medication: Allopurinol 0.1 0.2 0.7 0.1 0.9 -0.1 -0.1 0.6 -0.7 -0.6 0.0 -0.6 0.2 -0.2 0.6 0.4 0.3 0.3 0.3 0.1 0.2
Medication: Omeprazole 0.1 0.2 1.2 1.1 -0.2 -0.3 -0.0 -0.1 0.1 0.3 0.0 0.4 0.8 0.4 -0.0 -0.0 -0.2 0.4 -0.1 -0.3 0.1
Medication: Seretide 50 evohaler 0.5 0.6 2.8 1.2 0.7 1.3 0.7 -0.6 1.7 -0.0 0.0 0.5 1.0 -0.4 0.2 -0.3 0.8 0.0 -0.9 0.8 0.6
Mean time to correctly identify matches 1.0 1.9 7.6 1.5 -0.3 1.4 -0.4 1.6 -0.9 0.0 0.0 0.7 -1.0 2.0 0.8 2.1 1.2 2.5 2.8 0.7 0.9
Heart disease (mother) 0.2 0.3 1.2 0.9 -0.6 -0.2 -0.0 -0.1 0.2 1.0 0.0 0.9 0.5 0.4 -1.1 0.1 -0.1 0.5 0.0 -0.5 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 2.7 -1.2 1.2 -0.0 0.8 -0.9 0.3 -0.3 0.0 -1.6 -0.2 -0.7 -0.0 -0.8 0.5 -1.1 0.5 0.6 -0.3
Whole body fat mass 0.1 0.4 1.6 0.9 -0.5 0.7 0.4 0.5 0.1 -0.4 0.0 0.6 0.5 0.6 0.4 1.3 1.1 1.1 0.3 0.2 0.4
Leg fat mass (right) 0.1 0.4 1.1 0.3 0.6 0.4 1.0 -0.2 0.7 -0.9 0.0 -0.3 0.9 -0.8 0.3 0.4 1.0 -0.2 -0.5 0.3 -0.2
Arm predicted mass (right) 0.5 2.3 9.5 1.3 1.4 0.7 1.4 1.6 1.1 -1.2 0.0 -0.7 -1.2 0.2 1.6 2.4 3.1 1.7 2.2 1.2 1.1
Pulse rate, automated reading 0.7 2.3 7.7 -1.4 -2.1 -2.8 -1.9 1.7 -2.6 -0.9 0.0 -1.6 -0.0 -0.6 -0.7 0.3 -1.1 0.3 0.6 -2.3 -1.6
Alcohol intake frequency. 0.8 1.9 5.3 2.2 -0.5 0.7 0.7 -0.2 1.0 1.8 0.0 2.1 0.0 2.2 0.4 1.2 1.6 2.0 0.4 1.0 2.3
Comparative height size at age 10 1.1 5.8 22.7 1.4 -0.9 -0.9 -0.3 4.5 -1.8 -0.6 0.0 0.5 -2.9 2.5 1.5 4.0 2.3 3.6 4.8 -0.0 1.6
Number of full sisters 3.1 3.7 9.3 2.4 0.6 2.3 1.7 0.8 1.4 2.4 0.0 1.4 -1.4 2.5 1.9 1.7 2.6 1.9 1.3 2.5 3.0
Suffer from ‘nerves’ 0.8 1.2 5.3 0.2 -0.9 -0.6 0.8 1.3 0.8 2.3 0.0 0.8 -1.9 1.9 -0.0 -0.5 0.8 0.7 0.5 0.7 1.7
Overall health rating 1.1 2.4 6.5 2.5 0.4 0.8 1.4 0.3 2.5 1.7 0.0 1.9 -0.3 1.9 0.3 0.9 2.1 1.9 0.3 1.4 2.4
Chest pain or discomfort 0.7 1.0 5.5 0.7 1.2 1.3 1.3 -0.3 2.3 0.2 0.0 0.1 0.4 -0.2 1.2 -0.8 0.8 -0.2 -1.0 1.8 0.8
Had major operations 0.2 0.2 1.8 -0.1 -0.1 0.1 -0.4 1.4 0.8 0.1 0.0 -0.0 -0.5 0.2 -0.8 0.3 0.2 0.5 -0.3 -0.4 -0.1
Age at last live birth 0.9 1.3 4.0 -1.7 -0.5 -0.3 -0.3 -0.7 1.1 -0.6 0.0 -0.7 0.8 -1.4 -2.0 -1.3 -0.8 -1.9 -1.2 -1.2 -1.2
Family relationship satisfaction 0.4 0.5 2.7 0.8 0.1 -0.2 0.4 -0.0 1.1 1.6 0.0 0.8 -0.3 0.8 -0.2 -0.2 0.4 0.6 0.1 0.5 1.4
Leg pain on walking 2.4 3.0 11.8 2.8 -0.9 0.1 1.3 0.7 2.3 2.2 0.0 3.4 -0.8 2.7 -0.1 0.8 1.2 2.3 0.7 0.9 2.2
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 5.6 -1.2 -0.8 -0.7 -2.4 0.8 -1.5 -2.2 0.0 -2.2 -0.0 -0.1 0.3 1.4 -0.5 0.6 1.6 -1.2 -1.1
Commuting to job workplace: Car/motor vehicle 1.4 1.6 6.0 1.5 -1.1 0.7 -1.2 1.1 -0.0 0.3 0.0 1.7 -0.5 2.0 0.1 1.9 0.4 2.4 2.0 0.2 1.1
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 2.0 -0.3 0.9 0.4 -0.5 -1.0 -0.6 -1.4 0.0 0.0 0.8 -1.3 -0.7 0.0 -1.0 -0.6 -0.2 -0.6 -1.2
Medication: Aspirin 2.1 2.8 8.5 2.0 1.0 1.3 0.5 0.7 0.2 0.8 0.0 0.1 -1.4 2.1 1.8 2.3 2.5 2.5 2.9 1.5 2.0
Supplements: Vitamin C 1.0 1.2 3.5 -0.2 0.1 0.6 1.8 -0.9 1.5 0.7 0.0 1.4 1.5 -0.3 -1.4 -1.9 -0.3 -1.2 -1.7 0.5 0.2
Knee pain experienced in last month 0.9 1.4 4.9 1.2 0.3 0.7 1.7 -0.8 1.9 1.8 0.0 2.2 -0.3 1.4 -0.3 -0.4 0.9 0.6 -0.5 1.2 1.7
Hypertension (Self-reported) 0.7 1.8 5.1 2.0 0.7 0.8 0.3 1.3 -0.1 1.2 0.0 0.7 -1.3 1.3 1.7 2.2 1.9 2.2 1.7 0.6 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.3 2.7 8.1 -0.8 -2.1 -2.3 -2.4 2.9 -2.8 -0.7 0.0 -0.2 -0.6 1.3 -0.4 0.9 -1.5 1.5 2.0 -2.0 -0.9
Illnesses of father: Heart disease 0.3 0.4 2.2 0.6 0.7 -0.1 0.6 -0.1 0.2 0.6 0.0 -0.2 -1.5 0.5 0.2 0.1 0.6 0.5 1.3 0.9 0.8
Illnesses of siblings: Diabetes 1.6 2.0 6.5 1.5 0.0 0.5 -0.7 1.2 -0.6 0.7 0.0 0.5 -1.4 2.2 2.2 2.5 1.1 2.4 2.0 0.6 0.7
Smoking status: Previous 1.8 2.7 8.7 0.8 -0.6 -0.4 -0.7 2.5 -1.8 0.5 0.0 -0.1 -2.4 1.9 2.2 3.0 1.2 2.3 2.7 -0.1 0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.3 8.7 1.2 -0.1 -0.3 1.0 1.4 0.6 1.2 0.0 0.8 -2.2 2.4 1.0 1.7 1.9 2.1 3.0 1.4 1.3
Whole body fat-free mass 0.6 3.3 10.0 1.6 1.0 0.7 0.8 2.3 0.5 -1.0 0.0 -0.3 -1.9 1.2 1.8 3.1 3.2 2.7 3.0 1.2 1.5
Leg fat-free mass (right) 0.6 3.4 10.5 1.8 0.1 1.1 0.2 2.4 -0.2 -0.3 0.0 0.3 -1.7 2.1 1.7 3.2 2.9 3.0 2.8 1.0 1.6
Arm fat percentage (left) 0.1 0.4 1.8 0.6 -1.3 0.5 -0.6 0.1 -0.5 0.1 0.0 0.9 1.1 0.7 -0.2 0.7 -0.1 0.6 -0.7 -0.5 -0.3
Average weekly red wine intake 1.8 2.7 5.9 -1.9 0.1 -0.8 -0.6 -1.3 0.3 -1.9 0.0 -0.7 2.0 -2.1 -1.7 -2.4 -2.4 -2.4 -2.2 -1.0 -1.8
Handedness (chirality/laterality): Left-handed 0.2 0.3 1.2 -0.1 0.4 0.7 -0.9 -0.1 -0.7 -0.8 0.0 -0.4 0.1 -0.7 0.8 0.3 -0.1 0.0 -1.1 -0.1 0.1
Mood swings 0.8 1.5 4.8 0.7 0.3 1.8 1.7 -0.7 2.2 2.0 0.0 2.0 -0.4 0.8 -0.7 -0.5 0.9 -0.0 -0.9 1.4 1.4
Loneliness, isolation 0.8 1.1 4.9 1.4 -1.2 0.6 0.6 0.6 0.6 2.2 0.0 2.0 0.1 1.2 -0.6 -0.0 0.6 1.2 -0.4 0.2 1.3
Long-standing illness, disability or infirmity 0.3 0.5 1.5 0.3 0.0 -0.7 -0.3 1.0 -0.3 0.1 0.0 -0.8 -1.2 0.7 0.3 1.1 0.8 0.7 1.1 0.1 0.7
Ever had bowel cancer screening 1.2 1.5 5.3 -0.1 2.3 1.5 2.2 -1.2 1.6 0.8 0.0 0.5 -0.1 -0.7 0.2 -1.7 0.3 -1.0 -0.9 1.9 0.5
Diabetes diagnosed by doctor 1.1 1.8 7.9 1.4 -0.8 0.6 -0.9 1.8 -0.5 0.2 0.0 1.3 -1.0 2.5 0.6 1.5 0.6 2.8 2.1 0.2 1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 1.8 -0.9 -0.9 -0.2 -0.7 -0.5 -0.8 -0.9 0.0 -1.4 0.0 -0.7 -0.6 0.0 -0.3 -0.5 0.2 -0.9 -0.6
Friendships satisfaction 1.9 2.4 7.5 2.4 -0.8 0.7 0.7 0.5 0.4 2.0 0.0 2.3 -0.9 2.7 0.1 1.1 1.4 2.5 1.2 0.7 2.3
Qualifications: nursing, teaching 1.1 1.8 5.1 -1.8 -1.1 -2.0 -1.2 -0.2 -1.5 0.5 0.0 -0.4 0.9 -0.1 -1.2 -2.0 -2.3 -1.6 -2.1 -1.2 -0.7
Commuting to job workplace: Walk 0.6 0.6 2.3 -0.3 1.2 0.4 0.6 -1.0 0.3 0.4 0.0 -0.6 0.3 -1.0 1.1 -0.6 -0.3 -1.2 -1.5 0.6 -0.5
Eye problems/disorders: Cataract 0.3 0.3 1.0 0.0 -0.9 -0.4 -0.4 0.4 -0.3 0.6 0.0 0.9 0.3 0.8 -1.0 -0.5 -0.8 0.3 -0.2 -0.2 -0.0
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 2.8 0.0 -0.4 1.2 1.2 1.7 0.4 1.1 0.0 0.2 -1.1 1.1 0.6 -0.1 1.1 0.2 0.1 1.0 1.0
Medication for cholesterol 0.2 0.3 1.2 -0.5 -0.4 -0.8 0.1 1.1 -0.1 0.6 0.0 -0.6 -1.1 0.4 0.8 0.5 0.2 0.1 -0.2 0.4 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 3.2 -0.2 -0.9 -0.1 -1.2 1.3 -0.7 -1.8 0.0 -0.1 0.8 -0.6 -1.0 0.2 -0.8 -0.1 0.1 -1.2 -0.3
Back pain experienced in last month 1.4 2.0 9.0 1.1 -0.3 -0.8 1.3 1.0 1.8 3.0 0.0 2.3 -0.9 1.9 -0.1 -0.7 0.4 1.3 0.3 0.8 2.5
Mineral and other dietary supplements 1.5 2.0 7.0 -1.7 -0.6 -2.6 -1.9 0.6 -1.4 -1.3 0.0 -2.0 -0.5 -1.6 -1.3 -0.4 -1.4 -1.1 -0.1 -2.0 -1.6
Breast cancer (self-reported) 1.7 2.0 7.9 2.8 0.1 1.9 0.7 -1.2 0.2 2.2 0.0 2.6 1.0 1.4 1.0 0.6 0.8 1.4 -0.2 1.1 1.5
Asthma (self-reported) 1.9 3.7 16.3 1.4 2.3 2.3 3.7 -1.0 4.0 1.4 0.0 1.1 -0.7 0.3 0.5 -1.2 2.1 -0.6 -1.9 2.9 1.2
Osteoporosis (self-reported) 0.6 0.8 2.5 -0.7 0.7 1.0 0.4 -1.2 0.0 -0.2 0.0 -0.9 0.7 -1.6 -1.1 -1.1 -0.3 -1.3 -1.0 0.2 -1.1
Osteoarthritis (self-reported) 1.4 1.8 5.2 2.0 0.4 0.3 1.4 0.9 1.3 2.3 0.0 1.8 -1.0 1.8 0.8 1.0 1.6 1.7 -0.1 1.3 1.6
Medication: Aspirin 1.9 2.5 5.9 2.0 1.2 1.4 0.8 0.0 0.4 1.3 0.0 0.5 -1.1 2.1 1.8 1.9 2.2 2.1 2.4 1.8 1.9
Medication: Gliclazide 0.3 0.3 1.1 0.5 -0.5 0.5 -1.1 0.6 -0.2 -0.9 0.0 0.1 0.6 0.6 0.2 0.8 0.2 1.1 0.0 -0.3 0.2
Illnesses of father: None of the above (group 1) 1.1 1.4 4.6 -0.9 -0.1 -0.4 0.1 -1.2 0.2 -1.4 0.0 -0.6 2.1 -2.0 -1.4 -1.5 -0.9 -1.5 -0.8 -1.2 -1.5
Smoking status: Current 0.3 0.4 2.9 -0.7 -0.3 -0.8 -0.7 0.9 -0.4 0.2 0.0 -0.8 -1.1 0.4 -0.2 0.2 0.1 0.2 1.7 -0.1 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.1 6.5 14.4 3.0 2.3 2.6 2.0 1.2 1.6 3.2 0.0 2.1 -2.5 2.8 3.8 2.5 3.3 2.5 1.4 3.4 2.9
Whole body water mass 0.6 3.2 9.9 1.5 1.0 0.8 0.8 2.2 0.5 -1.0 0.0 -0.3 -1.8 1.2 1.8 3.1 3.1 2.6 3.0 1.1 1.5
Leg predicted mass (right) 0.6 3.3 10.7 1.8 0.1 1.1 0.2 2.4 -0.2 -0.4 0.0 0.3 -1.7 2.1 1.6 3.3 2.9 3.0 2.8 0.9 1.6
Arm fat mass (left) 0.1 0.4 1.6 0.8 -0.8 0.5 0.1 0.5 -0.1 -0.2 0.0 0.6 0.5 0.8 0.2 1.3 0.9 1.1 0.2 -0.1 0.2
Number of self-reported non-cancer illnesses 0.1 0.1 0.8 0.2 0.2 0.5 -0.1 0.1 -0.4 -0.1 0.0 -0.3 0.9 0.0 -0.1 -0.3 -0.0 0.4 -0.1 0.0 -0.1
Average weekly champagne plus white wine intake 2.8 3.8 13.3 -3.6 0.4 -2.0 -0.2 -1.1 -0.2 0.2 0.0 -1.9 -0.2 -2.3 -2.1 -3.1 -2.5 -3.6 -1.9 -1.0 -1.9
Miserableness 1.7 2.9 7.0 2.0 0.6 2.2 1.5 0.5 1.9 2.6 0.0 2.3 -1.3 2.1 0.8 1.0 1.6 1.6 0.6 2.1 2.6
Guilty feelings 2.0 3.1 8.2 1.9 0.7 1.6 2.4 0.3 1.9 2.9 0.0 1.7 -1.4 1.8 0.8 0.6 2.8 1.5 0.3 2.1 2.7
Wears glasses or contact lenses 0.9 1.0 3.5 -0.9 -1.7 -1.9 -1.3 0.3 -1.3 -0.4 0.0 -0.8 0.2 -0.7 -1.0 -0.8 -1.4 -0.6 -0.0 -1.4 -0.3
Ever taken oral contraceptive pill 0.7 0.8 2.8 -1.6 -0.3 -1.2 -1.2 0.4 -1.1 -1.2 0.0 -1.7 -0.7 -0.2 -0.2 0.3 -0.6 -0.3 0.7 -0.7 -0.9
Hearing aid user 1.6 1.9 6.0 -1.4 1.4 0.4 0.6 -1.6 0.7 0.0 0.0 -1.1 1.2 -2.4 -1.0 -1.7 -0.8 -2.5 -2.4 0.1 -0.9
Mother’s age at death 0.8 1.0 2.6 -1.6 -1.2 0.4 -0.5 -0.8 -1.0 -1.2 0.0 -1.2 1.0 -1.3 -0.9 -1.0 -1.0 -1.3 -0.4 -1.2 -1.0
Financial situation satisfaction 0.5 0.6 1.6 1.2 -0.3 0.1 0.1 1.0 0.3 0.6 0.0 0.6 -0.7 0.7 1.2 1.1 1.1 1.3 0.1 0.3 1.2
Tinnitus: Yes, now most or all of the time 0.8 1.0 4.3 -0.5 0.4 0.7 0.4 -1.0 -0.3 -0.8 0.0 -0.9 1.3 -2.1 -0.9 -1.3 -0.2 -1.6 -1.4 -0.6 -0.5
Commuting to job workplace: Public transport 0.4 0.5 2.1 -1.1 0.0 -0.2 0.1 -0.4 -0.7 0.1 0.0 -0.9 0.5 -0.7 -0.1 -1.5 -0.7 -1.0 -0.9 -0.6 -0.4
Eye problems/disorders: Glaucoma 0.8 0.9 3.8 0.5 0.3 0.3 -0.2 1.7 -0.8 -0.2 0.0 -0.5 -1.1 0.8 0.6 2.0 1.2 1.1 1.8 0.2 0.3
Medication: Blood pressure 0.3 0.6 2.6 1.6 0.9 1.6 0.5 -0.8 0.7 -0.1 0.0 0.8 0.6 0.2 0.3 0.6 1.1 0.5 0.5 0.3 0.9
Pain type(s) experienced in last month: Hip pain 1.2 1.5 5.7 1.5 -1.8 0.1 0.3 0.9 0.9 0.9 0.0 2.4 0.1 2.1 -1.1 0.3 0.5 1.9 0.2 -0.1 2.0
Supplements: Fish oil (including cod liver oil) 2.1 2.7 8.0 2.2 1.4 2.8 2.4 -0.9 1.7 1.0 0.0 1.8 0.4 1.2 2.2 0.7 1.7 1.4 0.2 2.7 1.3
High cholesterol (Self-reported) 0.1 0.2 1.8 -0.2 0.5 -0.4 -0.4 -0.4 0.1 -0.3 0.0 -0.2 -0.4 -0.1 -0.6 -0.1 -0.3 0.0 1.4 0.1 0.1
Medication: Bendroflumethiazide 0.6 1.0 2.8 0.0 -0.8 -1.0 -0.8 1.5 -1.4 0.3 0.0 -0.3 -1.6 1.0 0.5 1.2 0.3 1.2 1.7 -1.0 -0.4
Medication: Paracetamol 0.2 0.2 1.3 0.1 -0.7 -1.1 0.3 0.3 -0.2 0.9 0.0 -0.0 -0.4 0.3 -0.6 0.3 0.6 0.3 0.3 -0.6 -0.3
Medication: Lisinopril 2.4 3.1 8.0 1.1 -0.4 0.6 -0.5 2.7 -0.7 1.3 0.0 -0.1 -2.8 2.2 1.8 2.8 2.4 2.2 2.7 0.7 1.6
Medication: Atorvastatin 0.8 1.0 3.3 0.9 1.4 1.3 1.8 -1.2 0.4 0.4 0.0 0.0 0.5 0.4 0.7 0.3 1.4 0.6 1.6 1.5 0.9
Illnesses of father: High blood pressure 1.0 1.2 2.9 -1.5 -1.4 -1.7 -1.7 1.0 -1.3 -1.0 0.0 -1.5 -1.3 0.1 -0.6 0.6 -0.9 -0.1 0.1 -1.1 -1.0
Alcohol drinker status: Never 0.2 0.2 0.8 -0.5 -0.7 -0.1 -0.3 -0.3 -0.1 0.7 0.0 -0.2 0.7 0.3 0.1 -0.7 -0.3 -0.3 -0.9 -0.2 0.6
Ever smoked 1.0 1.7 7.1 0.1 -0.8 -0.9 -0.1 2.1 -1.3 0.6 0.0 -0.6 -2.7 1.3 1.6 1.8 1.0 1.3 2.3 -0.1 0.0
Basal metabolic rate 0.5 2.8 9.5 1.6 1.0 0.8 0.9 1.9 0.6 -0.9 0.0 -0.1 -1.6 1.1 1.7 2.9 3.1 2.4 2.6 1.2 1.4
Leg fat percentage (left) 0.5 1.7 5.8 -0.4 0.6 0.1 1.3 -1.5 1.1 -1.0 0.0 -0.3 2.2 -2.0 -0.8 -1.6 -0.3 -2.0 -2.4 0.1 -1.0
Arm fat-free mass (left) 0.4 2.0 7.9 1.2 1.6 0.7 1.5 1.3 1.2 -1.0 0.0 -0.4 -1.2 0.3 1.5 2.1 2.8 1.5 1.9 1.4 1.1
Number of operations (self-reported) 0.1 0.2 0.5 0.3 -0.3 -0.0 -0.7 0.5 -0.5 0.2 0.0 0.6 0.7 0.6 -0.7 0.3 -0.5 0.6 0.2 -0.7 -0.1
Average weekly beer plus cider intake 0.8 1.1 4.4 0.2 -0.7 0.9 -1.1 1.2 -2.1 0.3 0.0 -0.2 -0.6 1.3 1.7 1.6 0.3 1.5 1.3 0.2 0.4
Irritability 0.3 0.5 1.6 -0.1 0.3 0.3 0.1 1.2 -0.6 0.9 0.0 -0.0 -1.2 0.7 0.3 0.8 0.5 0.7 1.0 0.6 1.2
Risk taking 1.1 1.6 7.4 -1.5 1.2 -0.1 -0.8 0.1 -1.3 -2.4 0.0 -2.7 0.6 -2.0 0.5 0.2 -0.3 -1.2 0.1 -0.7 -1.9
Ever had prostate specific antigen (PSA) test 1.0 1.2 4.0 -0.5 1.1 0.3 0.5 -1.6 0.4 -0.1 0.0 -0.4 1.6 -2.0 -1.2 -1.5 -0.6 -1.9 -1.6 -0.2 -0.4
Fractured/broken bones in last 5 years 1.6 2.0 7.8 0.5 2.8 1.7 2.3 -0.6 2.3 1.6 0.0 1.3 -0.8 0.0 0.7 -1.2 0.6 -0.6 -1.2 2.2 1.0
Age started oral contraceptive pill 1.1 1.4 4.5 -1.4 -1.6 -1.5 -0.2 0.4 -0.7 -0.5 0.0 -0.1 0.2 -0.4 -2.1 -1.9 -1.6 -1.4 -1.6 -1.2 -0.9
Diastolic blood pressure, automated reading 1.7 5.2 19.8 2.6 -1.1 -0.0 -0.6 3.7 -1.6 0.4 0.0 1.2 -1.1 2.5 2.7 4.5 2.2 4.3 3.0 -0.2 0.8
Ever depressed for a whole week 2.4 3.0 8.0 -2.4 -2.3 -2.5 -2.8 2.0 -2.3 -1.4 0.0 -2.5 -0.6 -0.1 -1.1 0.6 -1.3 -0.0 1.3 -2.4 -1.0
Unable to work because of sickness or disability 1.4 1.9 5.0 1.6 0.9 1.7 0.6 1.1 0.9 0.5 0.0 0.5 -1.5 2.0 1.6 1.7 2.2 1.8 1.4 1.3 1.3
Commuting to job workplace: Cycle 2.6 3.1 7.9 1.2 2.8 2.5 2.5 -1.4 2.4 2.1 0.0 1.1 0.5 -0.2 0.9 -2.0 0.8 -0.9 -2.6 2.4 1.0
Myopia 0.5 0.7 2.5 0.2 1.4 1.0 0.0 0.5 0.9 -1.6 0.0 -0.4 -0.8 -0.6 1.4 0.9 1.0 0.2 -0.8 0.4 0.3
Vascular/heart problems diagnosed by doctor 1.2 3.1 8.6 -2.6 -1.7 -1.7 -1.5 -0.6 -0.8 -1.7 0.0 -0.8 1.7 -1.7 -2.0 -2.2 -2.9 -2.2 -2.0 -1.7 -1.7
Cholesterol lowering medication 0.4 0.6 2.8 1.2 -0.1 0.5 0.2 -0.9 -0.2 -0.1 0.0 1.1 0.3 1.0 -0.4 0.1 0.4 1.0 1.5 0.6 1.7
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 2.1 1.4 0.0 -0.0 0.2 0.4 0.5 1.0 0.0 1.2 0.0 1.1 0.0 0.2 0.1 1.0 0.3 0.3 1.0
Pain experienced in last month 0.4 0.6 2.3 -0.4 0.9 0.5 -0.9 -0.6 -0.6 -1.3 0.0 -1.5 -0.1 -0.9 1.2 1.1 0.3 -0.6 0.3 0.3 -1.0
Supplements: Calcium 1.6 1.8 4.6 0.7 0.6 2.1 2.1 -1.2 1.9 1.9 0.0 1.9 0.6 0.0 -0.6 -1.7 -0.1 -0.9 -1.6 1.5 0.8
Basal cell carcinoma (self-reported) 1.8 2.1 7.0 0.1 -0.6 -0.2 -2.0 1.9 -2.2 -2.2 0.0 -0.9 -0.7 -0.1 0.6 2.6 0.1 1.5 2.3 -1.5 -1.2
Heart attack/myocardial infarction (self-reported) 0.6 0.7 3.2 1.3 1.8 0.7 1.2 -0.8 0.4 -1.3 0.0 -0.4 0.1 -0.6 0.5 0.3 1.1 0.1 0.2 1.2 0.5
Deep venous thrombosis (DVT) (self-reported) 2.1 2.7 9.1 2.4 1.5 1.8 1.1 -0.1 0.1 0.8 0.0 1.2 -1.1 1.5 3.0 2.0 2.0 2.1 1.2 2.2 1.8
Heart disease (siblings) 0.5 0.6 3.1 0.6 1.1 0.8 1.0 -1.8 1.1 0.2 0.0 -0.2 0.5 -0.1 1.0 -0.1 0.6 -0.1 0.2 0.9 0.7
Alcohol drinker status: Previous 0.3 0.4 1.1 1.0 0.7 -0.1 0.9 -0.8 1.1 -0.1 0.0 0.0 0.3 -0.0 0.6 0.4 1.0 0.3 -0.5 0.5 0.5
Pack years of smoking 0.1 0.2 0.6 -0.1 0.7 -0.4 -0.2 0.7 -0.8 -0.1 0.0 -0.1 -0.6 -0.3 -0.1 0.8 -0.1 0.3 0.2 -0.2 -0.5
Impedance of whole body 0.2 1.0 4.5 1.1 -0.0 0.5 0.9 -1.7 0.9 1.8 0.0 2.1 -0.1 1.3 0.5 -0.2 0.2 0.3 -0.4 1.2 1.2
Leg fat mass (left) 0.1 0.3 1.0 0.3 0.2 0.3 0.8 -0.1 0.6 -1.0 0.0 -0.2 1.0 -0.7 0.1 0.3 0.8 -0.2 -0.6 0.2 -0.2
Arm predicted mass (left) 0.4 2.0 8.3 1.3 1.5 0.6 1.5 1.3 1.3 -1.0 0.0 -0.4 -1.2 0.2 1.5 2.1 2.9 1.5 1.9 1.3 1.2