[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr10:110,937,872-112,588,355

Best TWAS P=7.3e-10 · Best GWAS P=2.68e-10 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ADD3 0.06 0.03 bslmm 385 0.04 8.5e-06 -2.8 -5.5 5.0e-08 0.61 0.16 0.23 FALSE
2 GTEx Adipose Visceral Omentum ADD3 0.06 0.03 enet 7 0.04 4.1e-03 -6.1 -6.2 7.3e-10 0.96 0.03 0.95 TRUE
3 GTEx Artery Aorta ADD3 0.12 0.10 lasso 3 0.11 9.4e-07 -5.3 -5.4 6.1e-08 0.85 0.05 0.95 FALSE
4 GTEx Brain Cerebellar Hemisphere ADD3 0.40 0.34 lasso 6 0.45 4.2e-13 -5.3 -5.7 1.5e-08 0.89 0.18 0.82 FALSE
5 GTEx Brain Cerebellum ADD3 0.36 0.31 lasso 11 0.33 1.4e-10 -5.3 -5.4 5.2e-08 0.84 0.39 0.61 FALSE
6 GTEx Breast Mammary Tissue ADD3 0.08 0.05 lasso 3 0.04 3.4e-03 -5.3 -5.6 1.7e-08 0.85 0.03 0.83 FALSE
7 GTEx Breast Mammary Tissue (Female) ADD3 0.07 0.02 lasso 1 0.09 1.3e-03 -5.3 -5.3 1.4e-07 0.84 0.04 0.45 FALSE
8 GTEx Colon Sigmoid ADD3 0.10 0.04 lasso 7 0.03 3.3e-02 -4.9 -5.3 1.2e-07 0.91 0.03 0.90 FALSE
9 GTEx Heart Left Ventricle ADD3 0.10 0.02 enet 17 0.03 1.2e-02 -6.1 -5.3 1.2e-07 0.79 0.03 0.96 FALSE
10 GTEx Lung ADD3 0.07 0.05 lasso 4 0.04 2.2e-04 -5.1 -5.2 2.0e-07 0.79 0.33 0.62 FALSE
11 GTEx Nerve Tibial ADD3 0.08 0.07 lasso 3 0.04 4.3e-04 -5.3 -5.8 7.6e-09 0.88 0.03 0.97 FALSE
12 GTEx Pituitary ADD3 0.27 0.05 enet 9 0.08 4.0e-03 -4.2 -5.3 1.2e-07 0.86 0.12 0.66 FALSE
13 GTEx Spleen XPNPEP1 0.25 0.04 lasso 5 0.05 2.4e-02 -4.2 -5.2 2.4e-07 0.69 0.04 0.54 FALSE
14 GTEx Spleen ADD3 0.36 0.27 lasso 5 0.28 7.2e-08 -5.3 -6.0 1.7e-09 0.90 0.06 0.91 FALSE
15 GTEx Thyroid ADD3 0.06 0.00 enet 4 0.01 1.2e-01 -5.4 -5.7 1.2e-08 0.89 0.04 0.77 FALSE
16 ROSMAP Brain Pre-frontal Cortex ADD3 0.04 0.03 lasso 4 0.02 2.1e-03 -5.7 -5.8 7.3e-09 0.97 0.02 0.97 FALSE