[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr10:110,937,872-112,588,355

Best TWAS P=7.3e-10 · Best GWAS P=2.68e-10 conditioned to 1

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Adipose Visceral Omentum	ADD3	0.06	0.03	enet	7	0.04	4.1e-03	-6.1	-6.2	7.3e-10	0.96	0.03	0.95	TRUE
14	GTEx	Spleen	ADD3	0.36	0.27	lasso	5	0.28	7.2e-08	-5.3	-6.0	1.7e-09	0.90	0.06	0.91	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	ADD3	0.04	0.03	lasso	4	0.02	2.1e-03	-5.7	-5.8	7.3e-09	0.97	0.02	0.97	FALSE
11	GTEx	Nerve Tibial	ADD3	0.08	0.07	lasso	3	0.04	4.3e-04	-5.3	-5.8	7.6e-09	0.88	0.03	0.97	FALSE
15	GTEx	Thyroid	ADD3	0.06	0.00	enet	4	0.01	1.2e-01	-5.4	-5.7	1.2e-08	0.89	0.04	0.77	FALSE
4	GTEx	Brain Cerebellar Hemisphere	ADD3	0.40	0.34	lasso	6	0.45	4.2e-13	-5.3	-5.7	1.5e-08	0.89	0.18	0.82	FALSE
6	GTEx	Breast Mammary Tissue	ADD3	0.08	0.05	lasso	3	0.04	3.4e-03	-5.3	-5.6	1.7e-08	0.85	0.03	0.83	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ADD3	0.06	0.03	bslmm	385	0.04	8.5e-06	-2.8	-5.5	5.0e-08	0.61	0.16	0.23	FALSE
5	GTEx	Brain Cerebellum	ADD3	0.36	0.31	lasso	11	0.33	1.4e-10	-5.3	-5.4	5.2e-08	0.84	0.39	0.61	FALSE
3	GTEx	Artery Aorta	ADD3	0.12	0.10	lasso	3	0.11	9.4e-07	-5.3	-5.4	6.1e-08	0.85	0.05	0.95	FALSE
8	GTEx	Colon Sigmoid	ADD3	0.10	0.04	lasso	7	0.03	3.3e-02	-4.9	-5.3	1.2e-07	0.91	0.03	0.90	FALSE
9	GTEx	Heart Left Ventricle	ADD3	0.10	0.02	enet	17	0.03	1.2e-02	-6.1	-5.3	1.2e-07	0.79	0.03	0.96	FALSE
12	GTEx	Pituitary	ADD3	0.27	0.05	enet	9	0.08	4.0e-03	-4.2	-5.3	1.2e-07	0.86	0.12	0.66	FALSE
7	GTEx	Breast Mammary Tissue (Female)	ADD3	0.07	0.02	lasso	1	0.09	1.3e-03	-5.3	-5.3	1.4e-07	0.84	0.04	0.45	FALSE
10	GTEx	Lung	ADD3	0.07	0.05	lasso	4	0.04	2.2e-04	-5.1	-5.2	2.0e-07	0.79	0.33	0.62	FALSE
13	GTEx	Spleen	XPNPEP1	0.25	0.04	lasso	5	0.05	2.4e-02	-4.2	-5.2	2.4e-07	0.69	0.04	0.54	FALSE