Best TWAS P=1.44e-10 · Best GWAS P=2e-08 conditioned to 0.848
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | AP006621.5 | 0.52 | 0.14 | enet | 38 | 0.13 | 3.6e-04 | 3.9 | 5.3 | 1.1e-07 | -0.02 | 0.15 | 0.22 | FALSE |
| 2 | GTEx | Whole Blood | IFITM3 | 0.09 | 0.02 | enet | 12 | 0.07 | 5.2e-07 | -4.0 | -5.3 | 1.1e-07 | 0.62 | 0.02 | 0.92 | FALSE |
| 3 | NTR | Blood | IFITM3 | 0.19 | 0.10 | bslmm | 303 | 0.12 | 9.4e-38 | -5.6 | -6.4 | 1.4e-10 | 0.87 | 0.00 | 1.00 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | IFITM3 | 0.10 | 0.06 | lasso | 5 | 0.08 | 1.1e-10 | 4.7 | -5.2 | 2.1e-07 | 0.53 | 0.03 | 0.97 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | RP11-326C3.7 | 0.07 | 0.06 | lasso | 2 | 0.04 | 2.9e-06 | -5.3 | 5.3 | 1.5e-07 | -0.67 | 0.01 | 0.99 | FALSE |
| 6 | YFS | Blood | IFITM3 | 0.70 | 0.26 | enet | 78 | 0.43 | 2.0e-158 | -5.6 | -5.2 | 2.1e-07 | 0.72 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IFITM3 | 0.10 | 0.10 | lasso | 3 | 0.11 | 1.6e-21 | 4.7 | -5.4 | 5.6e-08 | 0.60 | 0.11 | 0.89 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | TSPAN4 | 0.09 | 0.04 | enet | 9 | 0.03 | 1.9e-04 | 4.6 | 5.7 | 1.2e-08 | -0.02 | 0.00 | 0.95 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IFITM3 | 0.04 | 0.01 | lasso | 4 | 0.01 | 1.2e-02 | -5.3 | -5.8 | 8.6e-09 | 0.68 | 0.01 | 0.77 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | IFITM3 | 0.08 | 0.01 | enet | 16 | 0.03 | 3.8e-04 | -2.9 | -5.5 | 4.5e-08 | 0.44 | 0.02 | 0.55 | FALSE |