TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Lung FEV1/FVC ratio
:
←
→
chr11:3,177,939-4,855,124
Best TWAS P=2.28e-10 · Best GWAS P=2.41e-10 conditioned to 1
3.2M
3.4M
3.6M
3.8M
4M
4.2M
4.4M
4.6M
4.8M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Lung
STIM1
0.19
0.20
lasso
5
0.19
3.5e-14
6.3
6.3
2.3e-10
1.00
0.01
0.99
TRUE
1
GTEx
Brain Putamen basal ganglia
RRM1
0.20
0.11
lasso
4
0.10
2.2e-03
4.1
6.0
2.4e-09
0.96
0.03
0.88
FALSE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
STIM1
0.03
0.04
blup
142
0.03
8.8e-05
5.8
-5.9
4.8e-09
-0.93
0.03
0.97
FALSE