Best TWAS P=8.8e-10 · Best GWAS P=1.78e-14 conditioned to 0.000772
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Muscle Skeletal | PLEKHA1 | 0.10 | 0.04 | lasso | 3 | 0.04 | 8.2e-05 | 6.08 | 5.2 | 1.5e-07 | -0.33 | 0.72 | 0.05 | FALSE |
| 2 | GTEx | Skin Sun Exposed Lower leg | PLEKHA1 | 0.16 | 0.02 | lasso | 5 | 0.01 | 4.0e-02 | 5.41 | 5.9 | 4.6e-09 | -0.32 | 0.46 | 0.03 | FALSE |
| 3 | METSIM | Adipose | PLEKHA1 | 0.05 | 0.03 | lasso | 4 | 0.04 | 3.6e-07 | -3.80 | 5.2 | 2.4e-07 | -0.44 | 0.95 | 0.01 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | PLEKHA1 | 0.06 | 0.05 | lasso | 4 | 0.05 | 1.3e-06 | 6.00 | 6.1 | 1.3e-09 | -0.41 | 0.98 | 0.01 | TRUE |
| 5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ARMS2 | 0.23 | 0.20 | lasso | 2 | 0.21 | 7.0e-09 | 5.17 | 5.8 | 6.9e-09 | -0.34 | 0.83 | 0.11 | FALSE |
| 6 | The Cancer Genome Atlas | Rectum Adenocarcinoma | PLEKHA1 | 0.45 | -0.01 | blup | 102 | 0.07 | 8.7e-03 | 4.24 | 6.1 | 8.8e-10 | -0.43 | 0.01 | 0.21 | TRUE |
| 7 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | ATE1 | 0.24 | -0.01 | blup | 126 | 0.03 | 5.0e-02 | 0.88 | -5.1 | 3.1e-07 | -0.04 | 0.02 | 0.05 | TRUE |