[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr11:8,233,876-11,227,175

Best TWAS P=1.4e-12 · Best GWAS P=3.48e-15 conditioned to 3.02e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Adipose Subcutaneous	TMEM9B	0.16	0.04	lasso	6	0.07	2.4e-06	6.2	7.1	1.4e-12	-0.56	0.39	0.44	TRUE
7	GTEx	Artery Tibial	DENND5A	0.17	0.08	lasso	6	0.08	4.2e-07	6.9	7.0	2.9e-12	0.09	0.00	1.00	TRUE
15	GTEx	Testis	SBF2	0.10	0.01	lasso	5	0.02	5.0e-02	-5.8	5.9	4.8e-09	0.02	0.34	0.06	TRUE
19	NTR	Blood	ADM	0.04	0.04	enet	13	0.04	1.6e-13	-5.8	5.5	3.2e-08	0.04	0.95	0.05	TRUE
5	GTEx	Artery Tibial	TMEM41B	0.16	0.03	enet	16	0.04	7.1e-04	-4.0	5.3	1.1e-07	0.02	0.49	0.09	TRUE
8	GTEx	Cells Transformed fibroblasts	AMPD3	0.20	0.02	lasso	8	0.01	5.5e-02	7.1	-5.2	1.9e-07	-0.01	0.01	0.98	TRUE
3	GTEx	Adipose Visceral Omentum	TMEM9B	0.12	0.03	enet	18	0.06	2.8e-04	2.0	7.0	2.8e-12	-0.25	0.05	0.39	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	DENND5A	0.19	0.03	blup	71	0.08	4.7e-08	-4.0	6.8	1.3e-11	0.07	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM9B	0.24	0.00	blup	52	0.03	1.4e-04	5.9	6.7	1.6e-11	-0.73	0.00	0.31	FALSE
16	GTEx	Thyroid	TMEM9B	0.20	0.03	enet	17	0.09	3.8e-07	-6.7	6.6	4.4e-11	-0.73	0.04	0.96	FALSE
17	GTEx	Thyroid	SCUBE2	0.17	0.02	lasso	7	0.04	2.4e-04	4.9	6.5	8.5e-11	-0.30	0.61	0.17	FALSE
11	GTEx	Heart Left Ventricle	SCUBE2	0.17	0.06	lasso	8	0.12	5.2e-07	4.7	6.5	9.4e-11	-0.51	0.37	0.61	FALSE
13	GTEx	Nerve Tibial	SCUBE2	0.23	0.11	enet	13	0.14	4.1e-10	4.7	6.5	9.7e-11	-0.43	0.98	0.01	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	C11orf17	0.09	0.02	lasso	4	0.01	1.3e-02	6.0	6.5	1.1e-10	-0.36	0.00	0.85	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	C11orf17	0.10	0.03	lasso	2	0.05	9.2e-07	5.9	6.4	1.6e-10	-0.46	0.00	1.00	FALSE
6	GTEx	Artery Tibial	SCUBE2	0.10	0.00	enet	14	0.01	5.8e-02	5.0	6.2	5.4e-10	-0.09	0.05	0.07	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM9B	0.34	0.08	blup	52	0.11	3.2e-11	5.8	6.1	1.3e-09	-0.39	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DENND5A	0.11	0.05	enet	11	0.09	8.5e-11	7.0	6.1	1.4e-09	0.07	0.52	0.48	FALSE
10	GTEx	Esophagus Muscularis	TMEM9B	0.12	0.06	lasso	7	0.10	9.5e-07	5.9	6.0	1.7e-09	-0.37	0.64	0.15	FALSE
23	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM9B	0.12	0.01	lasso	4	0.02	2.5e-02	5.9	6.0	2.5e-09	-0.37	0.00	0.91	FALSE
14	GTEx	Prostate	SBF2	0.21	0.05	lasso	7	0.03	6.7e-02	-5.8	-5.8	5.6e-09	-0.01	0.12	0.30	FALSE
12	GTEx	Nerve Tibial	TMEM9B	0.21	0.01	enet	37	0.05	3.5e-04	-4.6	5.8	6.7e-09	-0.49	0.18	0.27	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NRIP3	0.04	0.04	blup	58	0.04	1.8e-05	5.9	5.7	1.0e-08	-0.28	0.01	0.99	FALSE
18	METSIM	Adipose	NRIP3	0.03	0.02	lasso	11	0.02	1.3e-04	2.9	5.6	2.2e-08	-0.08	0.64	0.01	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM41B	0.10	0.00	enet	8	0.01	9.7e-03	-4.1	5.6	2.5e-08	0.07	0.00	0.36	FALSE
20	YFS	Blood	ADM	0.08	0.11	enet	25	0.12	9.4e-36	-5.8	5.5	3.2e-08	0.02	0.95	0.05	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM9B	0.45	0.07	blup	52	0.12	4.2e-12	-2.2	5.5	4.8e-08	-0.66	0.91	0.06	FALSE
9	GTEx	Esophagus Muscularis	AKIP1	0.21	0.01	enet	25	0.07	2.6e-05	-6.5	5.4	7.1e-08	-0.63	0.10	0.66	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	DENND5A	0.12	0.02	blup	71	0.05	2.0e-04	4.1	5.4	7.1e-08	0.03	0.03	0.25	FALSE
4	GTEx	Artery Tibial	AKIP1	0.12	0.07	enet	32	0.09	1.0e-07	-6.7	5.3	1.1e-07	-0.57	0.05	0.95	FALSE