Hub : Genes

RERG

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.112	0.0360	7.8e-05	0.074	0.043	0.064	0.054	0.076	2.3e-09	5.3e-06	2.8e-08	3.3e-07	1.4e-09
2	GTEx	Nerve Tibial	0.100	0.0405	2.4e-03	0.008	NA	0.009	NA	0.009	8.4e-02	NA	7.3e-02	NA	7.3e-02
3	GTEx	Spleen	0.285	0.1030	7.2e-03	-0.007	NA	0.041	NA	0.028	5.2e-01	NA	3.3e-02	NA	6.6e-02
4	GTEx	Testis	0.180	0.0700	2.5e-03	0.013	NA	0.045	NA	0.009	8.0e-02	NA	4.7e-03	NA	1.2e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.223	0.0439	3.2e-10	0.099	0.095	0.097	0.097	0.044	1.2e-12	3.4e-12	1.9e-12	2.0e-12	2.4e-06
6	TCGA	Colon Adenocarcinoma	0.091	0.0450	1.1e-03	0.039	0.031	0.008	NA	0.002	2.6e-03	6.6e-03	1.1e-01	NA	2.3e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.7	1.1	2.9	-1.1	0.1	-0.9	0.3	-1.2	-1.7
Bipolar Disorder or Schizophrenia	0.7	1.6	7.9	-0.5	0.9	-0.7	0.4	-0.2	-2.8
Depressed Affect (Nagel 2018)	0.3	0.7	2.3	1.1	0.2	-0.3	0.6	1.5	0.6
Depression (Nagel 2018)	0.3	0.5	1.3	-0.8	-0.2	-1.1	0.6	-0.6	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.6	-0.1	-0.2	-0.1	0.6	-0.7	-0.1
Neuroticism (Nagel 2018)	0.2	0.5	2.4	-0.1	-0.6	-0.1	-0.3	0.1	1.5
Schizophrenia (2018)	0.5	1.1	5.0	0.2	1.0	-0.2	0.4	0.6	-2.2
Schizophrenia vs Biploar Disorder	0.7	0.9	2.7	0.6	1.6	1.1	0.6	1.0	-0.3
Worry (Nagel 2018)	0.2	0.5	1.4	-1.2	-0.9	0.2	-0.1	-0.8	0.3
Alzheimer’s Disease (in mother)	0.5	0.6	1.3	0.6	0.6	1.1	0.9	0.6	0.4
Alzheimer’s Disease (in father)	1.6	1.7	7.1	-1.0	1.3	-0.1	2.7	-0.5	-0.6
Alzheimer’s Disease (including proxy)	1.0	1.4	6.2	0.4	1.1	0.4	2.5	0.7	0.0
Crohns Disease (2017)	0.6	1.3	5.1	-1.2	0.2	0.2	-0.3	-1.1	-2.3
Irritable Bowel Disease (IBD)	0.5	1.2	4.6	-1.1	0.9	-0.5	0.1	-0.5	-2.2
Ulcerative Colitis (UC)	0.6	1.1	2.8	-1.0	1.1	-0.9	0.7	-0.2	-1.7
Major Depression (MDD)	0.4	0.5	1.5	0.5	0.6	-0.8	1.2	-0.1	0.3
Reaction Time	0.6	1.1	2.7	0.7	1.0	0.3	-0.6	1.5	1.6
Verbal and Numeric Reasoning (VNR)	0.3	0.8	4.5	-0.1	2.1	0.2	0.1	-0.6	-0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.2	0.3	0.5	0.3	-0.5	-0.7	-0.7	0.4	0.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.5	0.7	2.4	0.2	-1.2	-0.7	-1.6	-0.1	0.1
Bipolar Disorder (2011)	0.8	0.8	2.2	-1.0	-0.9	-0.9	0.3	-1.5	-0.0
Body Mass Index (BMI) (2010)	0.4	0.5	1.8	0.1	1.3	0.3	1.0	0.4	0.2
Coronary Artery Disease (CAD)	1.2	1.4	4.8	-0.6	0.2	-1.8	0.2	0.0	-2.2
Crohns Disease (2012)	1.2	1.9	9.5	-0.6	0.8	0.5	0.6	-0.1	-3.1
Mean Putamen Volume	0.4	0.5	0.9	0.5	0.4	-0.1	0.8	0.9	-0.9
Fasting Glucose	1.3	1.6	4.0	-0.9	1.4	-0.5	1.5	-0.2	-2.0
HbA1C	0.3	0.3	0.7	0.8	-0.2	0.4	0.4	0.6	0.7
HDL Cholesterol	0.1	0.2	0.5	0.6	-0.5	0.5	0.2	0.7	-0.1
LDL Cholesterol	0.7	1.1	2.2	0.8	0.9	0.8	-1.5	1.0	1.1
Lupus	1.4	2.2	5.7	1.3	-0.7	1.3	-1.3	1.3	2.4
Neuroticism (2016)	0.6	0.9	1.8	1.0	-1.1	-0.2	0.2	1.3	1.3
Primary Biliary Cirrhosis	0.7	1.0	2.5	1.0	0.9	1.6	0.3	0.9	0.7
Rheumatoid Arthritis	1.5	2.0	5.1	-0.6	2.3	1.4	2.1	-0.5	-0.4
Schizophrenia (2014)	0.8	1.7	6.4	0.7	0.9	-0.6	0.7	1.2	-2.5
Triglycerides	0.7	1.1	3.0	1.7	-0.4	0.9	0.0	1.4	0.8
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.7	1.1	-0.7	0.7	1.6	1.3	0.1
Ulcerative Colitis	0.6	0.8	1.4	-0.8	1.2	-1.0	0.9	-0.4	-1.0
Blood Eosinophil Count	0.1	0.9	1.8	-0.6	-0.2	-1.3	1.4	-0.4	-1.1
Blood Platelet Count	0.4	4.4	14.3	-1.8	1.8	3.8	0.7	-2.1	0.8
Blood Red Count	1.0	9.8	36.0	-3.5	1.7	-1.1	0.9	-2.3	-6.0
Blood White Count	0.3	2.0	4.7	-2.1	0.1	-0.5	0.0	-1.7	-2.2
Heel T-Score	1.3	10.6	29.5	-3.7	5.4	-0.0	2.3	-2.9	-2.7
BMI	0.3	1.5	3.4	1.2	1.9	-0.3	-0.0	1.5	1.2
Height	0.1	1.1	3.3	0.7	1.1	-0.8	-1.0	-0.3	1.8
Waist Hip Ratio (WHR)	0.4	2.0	7.3	1.2	-1.0	-0.6	-1.0	1.0	2.7
Systolic Blood Pressure	0.3	1.5	3.0	1.5	-0.4	1.2	-0.9	1.3	1.7
Smoking Status	0.6	1.5	2.3	-1.4	-1.5	0.9	1.1	-1.1	-1.2
Allergy or Eczema	0.6	1.6	3.9	-1.8	-0.7	0.2	-0.6	-2.0	1.3
Cardiovascular Disease	0.1	0.5	1.7	0.0	1.3	-0.5	0.1	0.7	-0.6
Hypothyroidism (self reported)	0.7	1.7	5.5	1.1	-1.0	-2.3	-0.5	0.9	1.1
Respiratory disease	0.3	0.7	3.7	-0.3	-0.5	-1.9	0.4	0.1	-0.3
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.8	2.0	0.6	0.2	-1.2	1.3	1.7
Lung FEV1/FVC ratio	4.1	20.7	66.6	8.2	-0.1	-1.2	-1.1	5.5	4.9
Lung FVC	0.2	0.8	2.3	1.1	-0.8	0.6	0.2	-0.1	1.5
Neuroticism	0.3	0.7	1.3	0.5	-1.1	-0.1	1.0	0.9	1.1
Chronotype (morning person)	0.2	0.5	1.1	0.5	-0.2	0.2	1.1	1.1	0.2
Hair Pigment	0.0	0.4	1.2	-0.4	1.1	0.6	-0.6	0.3	-0.2
Tanning	0.0	0.5	1.0	-0.7	-1.0	-0.4	0.8	-0.4	-0.9
Hand grip strength (left)	3.6	9.6	32.0	-1.9	5.7	3.1	0.9	-2.5	-2.3
Number of treatments/medications taken	0.4	0.7	1.0	-0.6	-1.0	-1.0	-1.0	-0.2	1.0
Average weekly spirits intake	1.8	2.2	7.2	1.2	-0.7	0.1	-1.6	1.2	2.7
Sensitivity / hurt feelings	0.5	0.8	3.9	0.6	-0.2	0.1	0.0	0.6	2.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	-0.8	-0.6	0.2	0.0	-0.7	0.2
Hearing difficulty/problems: Yes	1.5	2.3	6.6	2.1	0.7	-0.4	0.0	2.6	1.4
Relative age of first facial hair	0.6	1.3	4.2	0.2	1.4	-0.7	2.1	-0.0	-1.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	0.5	-0.1	-0.2	-0.8	0.8	0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.4	0.7	-0.3	-0.7	-0.1	1.2	0.3
Ever had hysterectomy (womb removed)	0.5	0.5	1.0	0.9	-0.4	1.0	-0.0	1.0	0.3
Systolic blood pressure, automated reading	0.4	1.0	1.8	1.3	0.2	-0.3	-1.3	1.3	0.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.0	-1.4	0.8	0.4	0.6	-1.0	-1.1
Angina	0.9	1.1	3.1	-0.1	1.2	0.2	-1.7	-0.1	1.5
Medication for hormone replacement therapy	0.3	0.3	0.9	0.3	-0.5	1.0	0.5	-0.1	0.7
Vitamin and mineral supplements	0.2	0.2	0.4	0.7	0.2	-0.5	0.6	0.5	-0.2
Supplements: Zinc	1.6	1.8	3.8	-1.9	-0.3	-1.0	-0.1	-1.9	-1.6
Medication: Co-codamol	0.6	0.6	2.5	1.0	0.2	0.3	0.2	1.6	0.6
Medication: Metformin	0.8	1.1	2.4	1.5	0.8	0.4	-0.3	1.5	1.2
Diabetes (father)	0.2	0.2	0.8	0.3	-0.9	-0.1	-0.2	0.6	0.1
Diabetes (mother)	0.4	0.6	2.4	0.1	0.4	0.0	-0.9	-0.0	1.5
Severe depression (siblings)	1.7	1.9	4.3	0.4	-1.5	-1.9	-1.0	0.1	2.1
Pack years adult smoking proportion	1.2	1.8	3.4	1.8	0.4	1.2	1.8	1.6	0.3
Impedance of leg (right)	0.4	1.7	4.4	1.5	-1.3	0.4	-0.3	1.3	2.1
Leg fat-free mass (left)	0.0	0.2	0.9	0.4	1.0	0.3	-0.3	-0.0	0.4
Trunk fat percentage	0.9	3.7	6.6	2.4	-0.2	-1.1	-1.5	2.6	2.5
Hand grip strength (right)	3.6	9.7	34.0	-1.9	5.8	3.1	0.1	-2.7	-1.9
Townsend deprivation index at recruitment	1.0	1.4	4.6	-0.4	0.0	1.6	2.1	-0.3	-0.9
Current tobacco smoking	0.7	1.2	3.2	0.7	0.4	1.0	1.8	0.6	-1.4
Average weekly fortified wine intake	2.3	2.7	11.0	-0.3	-1.7	-3.3	-1.3	-0.4	0.5
Maternal smoking around birth	0.3	0.4	1.3	-0.6	-0.1	-0.7	-0.2	-0.5	1.2
Fed-up feelings	0.8	1.5	2.9	1.2	-1.3	-0.5	-0.0	1.7	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	0.4	-0.8	-0.1	0.7	0.2	0.2
Relative age voice broke	0.6	0.9	2.8	0.4	0.9	-1.2	1.7	0.2	-0.5
Taking other prescription medications	0.9	1.3	4.8	-2.2	-0.6	-0.8	-0.0	-1.5	-0.3
Age when periods started (menarche)	0.2	0.4	0.9	0.4	0.9	0.2	0.9	0.2	-0.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.9	1.6	-0.4	-0.5	0.4	1.7	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	4.9	0.5	2.2	-0.2	1.0	0.7	0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.1	0.7	-0.1	-1.0	0.3	0.1	-0.0
Qualifications: CSEs or equivalent	1.0	1.3	2.3	0.9	-1.5	1.3	-0.6	1.1	1.1
Serious illness, injury or assault to yourself	1.2	1.5	4.0	0.3	0.1	0.1	1.9	1.1	-2.0
High blood pressure	0.3	0.9	3.1	-0.7	1.8	-0.5	-0.7	-0.2	-1.1
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	-1.1	-0.4	0.6	0.5	-1.0	0.8
Multivitamins +/- minerals	0.7	0.9	2.6	-1.4	0.4	0.8	-0.1	-1.6	-0.3
Stomach or abdominal pain in last month	0.3	0.4	1.1	0.6	0.6	1.1	-0.5	0.6	0.1
Supplements: Glucosamine	1.7	2.2	5.3	-1.4	-2.3	-1.4	-1.5	-1.2	-0.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.3	-0.9	1.1	0.3	0.5	-1.1	-0.8
Medication: Atenolol	1.0	1.3	4.0	-1.0	-1.4	-2.0	-0.1	-0.4	0.6
Medication: Levothyroxine sodium	0.5	0.9	2.4	-0.4	-1.6	-1.4	-0.0	-0.6	0.6
Sitting height	0.7	4.9	11.0	-2.6	3.0	0.8	0.6	-3.3	-1.4
Chronic bronchitis/emphysema (father)	1.9	2.2	6.5	-2.5	-0.9	-0.6	0.4	-2.1	-0.9
High blood pressure (mother)	1.0	1.4	2.5	-1.6	0.0	-0.7	1.4	-1.0	-1.6
Body mass index (BMI)	0.4	1.7	2.8	1.4	1.0	-0.6	-1.7	1.4	1.5
Impedance of leg (left)	0.2	1.1	3.4	1.2	-0.9	0.5	0.1	0.9	1.9
Leg predicted mass (left)	0.1	0.3	0.9	0.5	1.0	0.4	-0.2	0.1	0.4
Trunk fat mass	0.7	3.2	6.0	2.2	0.4	-0.9	-1.6	2.2	2.4
Waist circumference	0.7	2.6	5.9	1.6	0.4	-0.9	-2.0	1.4	2.4
Number of incorrect matches in round	0.4	0.7	2.0	1.2	-0.5	-0.1	-0.0	1.4	-0.7
Past tobacco smoking	0.9	1.7	4.2	2.1	1.5	0.7	0.4	1.7	0.6
Alcohol usually taken with meals	1.5	2.4	9.7	-0.7	0.8	-3.1	-1.4	-0.8	-0.9
Nervous feelings	0.5	0.9	1.5	-1.2	-1.2	0.5	0.8	-1.1	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.3	-0.0	-1.2	0.7	1.0	0.1	0.9
Hearing difficulty/problems with background noise	0.5	0.8	1.6	-0.8	1.0	1.1	1.3	-0.2	0.4
Hair/balding pattern: Pattern 2	1.9	2.4	5.1	-1.0	0.2	2.3	2.2	-1.1	-1.5
Had menopause	0.7	0.8	1.8	-0.3	1.4	-0.2	1.2	0.1	-1.3
Had other major operations	0.3	0.4	1.5	-0.3	0.2	-1.2	-0.8	-0.4	0.0
Forced vital capacity (FVC)	0.3	1.2	4.6	1.4	-0.2	0.5	-0.5	-0.1	2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	3.6	1.7	1.3	-0.9	0.4	1.9	1.2
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.9	1.4	0.4	0.2	0.5	1.7	-0.7
Qualifications: None of the above	1.0	2.1	3.6	1.5	1.3	1.9	1.3	1.8	-0.5
Financial difficulties in last 2 years	0.3	0.4	0.6	-0.7	-0.1	0.8	0.6	-0.8	0.5
Mouth/teeth dental problems	0.1	0.2	0.7	0.8	0.1	0.0	-0.3	0.3	0.4
Heart attack	0.8	1.0	2.5	-0.4	-1.6	-0.7	-0.7	-0.3	1.5
Allergy	0.2	0.5	1.1	1.0	0.5	0.0	-0.6	1.1	-0.5
Pain all over the body in last month	0.6	0.6	1.9	-0.6	-0.5	-0.5	0.9	-0.2	-1.4
Diabetes (self-reported)	0.7	1.0	1.8	1.2	0.7	-0.1	-1.1	1.1	1.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.5	0.9	0.4	-1.1	-0.3	1.2	0.8
Medication: Ramipril	0.4	0.5	1.2	-0.8	1.1	0.1	-0.6	0.1	-0.9
Medication: Simvastatin	0.5	0.8	3.4	0.5	0.6	-0.1	-1.8	0.7	0.1
Fluid intelligence score	0.2	0.4	0.9	0.3	0.9	-0.2	-1.0	-0.3	0.7
Illnesses of siblings	0.7	1.0	1.9	-0.7	-1.1	-0.2	1.3	-0.7	-1.4
Neuroticism score	0.2	0.3	0.9	-0.0	-0.5	0.8	0.3	0.4	1.0
Weight	0.3	1.6	2.4	1.5	1.2	-0.4	-1.3	1.2	1.6
Impedance of arm (right)	0.3	1.6	5.5	0.5	-2.3	-1.6	0.9	0.7	-0.0
Arm fat percentage (right)	0.8	3.3	6.0	2.2	0.2	-0.9	-1.7	2.3	2.4
Trunk fat-free mass	0.2	1.0	3.8	-0.2	1.9	1.2	-0.5	-0.8	-0.1
Hip circumference	0.3	1.5	2.3	1.3	1.5	-1.3	-1.2	1.1	0.6
Time employed in main current job	0.0	0.1	0.2	-0.1	0.4	0.2	-0.3	-0.1	0.1
Alcohol intake versus 10 years previously	0.3	0.5	1.7	-0.8	0.2	0.2	0.6	-1.3	0.2
Father’s age at death	0.4	0.5	1.0	-1.0	-0.9	-0.5	0.2	-0.8	-0.8
Worrier / anxious feelings	0.1	0.2	0.5	-0.7	0.3	-0.1	-0.7	-0.5	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.2	0.5	-0.7	-0.5	0.1	0.6	-0.6	0.2
Falls in the last year	2.1	2.9	6.6	1.8	0.9	1.5	2.6	2.1	0.0
Hair/balding pattern: Pattern 3	1.2	1.7	3.5	-0.5	-1.8	-1.9	-1.8	-0.4	0.4
Number of live births	1.8	2.5	7.7	0.5	1.4	0.7	2.8	0.8	-1.9
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	10.6	3.1	-0.1	0.4	-0.7	0.9	3.3
Pulse rate	0.5	0.9	3.5	-0.3	-0.8	-1.9	-0.6	-0.4	-0.8
Happiness	0.4	0.5	1.8	-0.2	0.2	0.6	1.3	-0.6	-0.5
Noisy workplace	2.1	2.6	5.5	2.1	-1.9	-0.1	-0.3	2.3	1.3
Qualifications: A levels/AS levels or equivalent	0.7	1.5	5.5	-1.4	-0.4	-0.6	-0.6	-2.4	0.7
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	3.9	-1.0	0.2	2.0	1.1	-1.0	0.4
Mouth/teeth dental problems: Dentures	0.2	0.4	1.3	0.4	0.4	1.1	-0.1	0.4	0.8
Asthma	0.2	0.3	0.9	-0.9	0.0	-0.6	0.2	-0.7	0.1
Medication: Ibuprofen (e.g. Nurofen)	2.8	3.6	7.0	2.7	-2.4	0.9	0.2	2.2	1.7
Medication: Cholesterol lowering	0.9	1.4	3.1	-1.2	-0.0	-1.0	-1.8	-0.9	-1.5
Depression (self-reported)	0.6	0.8	3.2	-1.0	-1.8	-0.2	-0.2	-0.6	-0.1
Medication: Lansoprazole	0.4	0.5	1.1	0.3	-0.0	-0.9	-0.1	1.0	-0.9
Prospective memory result	0.6	0.7	2.4	0.2	-1.0	-1.6	-0.4	0.5	-0.5
Lung cancer (father)	0.9	1.1	1.5	1.2	-1.1	1.2	-0.0	1.1	1.1
Illnesses of mother	0.9	1.1	2.3	1.5	0.2	1.0	-1.1	1.1	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.6	14.7	3.0	-0.5	0.5	-1.6	0.9	3.8
Pulse wave Arterial Stiffness index	1.5	1.7	3.1	0.9	-1.5	-0.1	-1.7	1.1	1.8
Impedance of arm (left)	0.4	2.0	6.4	0.7	-2.5	-1.9	0.7	0.8	0.2
Arm fat mass (right)	0.6	2.6	3.9	1.9	1.0	-0.7	-1.8	1.9	2.0
Trunk predicted mass	0.2	0.9	3.4	-0.2	1.9	1.1	-0.4	-0.8	-0.3
Standing height	0.0	0.2	0.6	0.1	0.7	0.0	0.4	-0.8	0.0
Length of working week for main job	1.2	1.3	2.7	1.6	0.1	1.1	1.3	1.3	0.8
Exposure to tobacco smoke at home	0.7	0.8	2.7	-0.3	-1.6	-1.0	-0.0	-0.4	-0.8
Breastfed as a baby	1.0	1.3	3.5	1.0	-0.4	-1.9	-0.9	0.9	-1.1
Tense / ‘highly strung’	0.7	1.1	3.5	-0.3	-1.5	-0.8	-1.9	0.0	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.5	1.1	0.5	0.7	0.8	1.6	0.2
Hair/balding pattern: Pattern 4	0.3	0.8	1.8	0.0	0.2	-1.3	-1.4	0.0	1.2
Birth weight of first child	0.6	1.1	2.3	1.4	-0.5	0.1	-0.9	1.5	1.1
Peak expiratory flow (PEF)	0.4	0.8	3.5	0.9	-0.0	-0.0	-0.7	-0.4	1.9
Pulse wave reflection index	0.3	0.4	1.0	-1.0	-0.2	0.6	0.4	-0.5	0.8
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.5	-0.9	0.7	-0.3	-1.6	-0.8	-0.6
Loud music exposure frequency	0.8	0.9	3.5	-0.8	-0.1	-0.9	0.3	-0.3	-1.9
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.0	-0.5	-1.3	-1.4	-1.1	-1.1	1.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.6	-1.1	0.3	-0.8	0.2	-0.2	-1.9
Blood clot in the leg (DVT)	1.1	1.4	4.9	0.9	1.5	2.2	0.2	0.8	0.2
Medication: Paracetamol	0.4	0.7	1.1	-0.7	-0.3	-1.0	-0.9	-0.7	1.0
Headache pain in last month	1.2	2.0	5.4	0.9	-2.3	0.0	-0.9	0.7	2.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.4	1.1	-1.0	0.6	1.2	0.7	1.0
Glaucoma (self-reported)	0.8	1.0	2.3	-1.5	-1.2	0.5	-0.2	-1.3	0.2
Gout (self-reported)	0.8	1.1	3.2	-1.8	0.1	-0.5	-0.0	-1.5	-1.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	2.4	0.1	-0.6	-1.5	-0.1	-0.0	0.7
Medication: Amlodipine	0.5	0.7	2.4	-1.0	-0.3	-0.7	-0.5	-0.4	-1.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	-0.8	0.5	0.4	1.1	-0.4	0.3
Birth weight	0.1	0.3	0.7	0.3	-0.8	0.4	-0.6	0.0	0.7
Chronic bronchitis/emphysema (mother)	1.9	2.2	7.2	0.7	-1.1	-0.1	-2.0	0.8	2.7
High blood pressure (siblings)	0.3	0.4	0.8	-0.0	0.9	0.8	-0.7	0.3	0.3
Forced vital capacity (FVC), Best measure	0.5	1.8	6.6	1.5	-0.9	0.3	-1.2	0.0	2.6
Body fat percentage	1.1	4.4	8.2	2.6	0.2	-1.1	-1.6	2.8	2.9
Leg fat percentage (right)	1.6	6.0	10.2	3.0	0.6	-1.1	-2.2	3.2	3.2
Arm fat-free mass (right)	0.2	1.2	5.1	0.6	2.3	1.2	-0.6	-0.0	0.4
Exposure to tobacco smoke outside home	0.2	0.3	1.1	-0.3	-0.5	-1.1	-0.4	-0.1	0.5
Comparative body size at age 10	0.4	1.1	3.5	0.0	0.3	0.2	-1.7	-0.3	1.9
Number of full brothers	1.1	1.4	4.0	1.7	-0.6	-0.6	-0.0	2.0	0.9
Worry too long after embarrassment	0.6	1.0	2.5	-0.9	0.0	1.6	0.1	-1.2	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.6	1.0	-0.4	1.4	0.5	1.6	0.6
Wheeze or whistling in the chest in last year	0.3	0.6	1.4	-0.4	-0.7	1.0	-0.3	0.2	1.2
Number of children fathered	2.1	2.3	6.6	2.1	0.3	-1.5	-0.7	2.6	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	4.0	-0.1	-0.3	0.8	-2.0	-0.3	0.5
Age at first live birth	0.4	0.6	1.4	-0.1	-1.1	0.3	-0.3	-1.0	1.2
Pulse wave peak to peak time	1.7	2.0	3.2	-1.0	1.7	-0.0	1.8	-1.2	-1.8
Health satisfaction	0.1	0.2	0.4	-0.6	-0.2	-0.5	-0.1	-0.3	-0.5
Shortness of breath walking on level ground	0.5	0.5	1.0	-0.8	-0.5	1.0	-0.8	-0.7	0.5
Qualifications: College or University degree	0.2	0.7	2.6	-0.4	-0.5	-0.1	-1.1	-1.6	0.5
Eye problems/disorders: None of the above	1.9	2.2	6.2	1.5	2.5	1.1	0.7	1.3	1.2
Mouth/teeth dental problems: Loose teeth	0.9	1.1	1.9	-1.1	0.2	-1.1	0.7	-1.4	-1.3
Emphysema/chronic bronchitis	1.5	1.7	5.0	0.5	-1.7	-2.2	-1.1	0.6	0.6
Medication for pain relief, constipation, heartburn	0.5	0.9	2.1	-0.9	0.5	-0.0	1.0	-1.0	-1.4
Neck or shoulder pain in last month	0.8	1.2	3.7	1.1	-0.7	1.1	0.5	0.7	1.9
Medication: Blood pressure	0.4	0.7	1.9	-1.2	1.4	0.0	0.0	-0.7	-0.5
Angina (self-reported)	0.8	1.0	2.3	-0.4	1.5	0.5	-1.3	-0.4	1.2
Migraine (self-reported)	0.7	0.9	3.2	0.6	-1.8	-1.0	-0.6	0.4	0.3
Medication: Ibuprofen	3.0	3.6	8.0	2.8	-2.3	0.8	0.7	2.2	1.5
Medication: Allopurinol	0.4	0.5	2.6	0.1	0.3	1.6	0.5	0.3	-0.4
Medication: Omeprazole	0.3	0.4	1.1	-1.0	-0.7	-0.1	-0.7	-0.7	-0.1
Medication: Seretide 50 evohaler	0.7	0.8	2.0	0.6	-0.7	-0.7	-1.4	1.1	0.3
Mean time to correctly identify matches	1.5	2.8	7.4	2.0	0.8	-0.4	-1.2	2.7	1.8
Heart disease (mother)	0.3	0.3	1.1	-0.2	0.5	-0.4	1.1	-0.5	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	4.8	-0.8	1.0	-2.2	-1.3	-0.5	-1.1
Whole body fat mass	0.8	3.3	6.3	2.2	0.9	-0.8	-1.7	2.1	2.5
Leg fat mass (right)	1.3	4.9	9.6	2.7	1.0	-0.7	-2.1	2.6	3.1
Arm predicted mass (right)	0.2	1.1	4.6	0.4	2.1	1.1	-0.5	-0.2	0.5
Pulse rate, automated reading	1.0	3.1	5.8	-2.4	0.7	-0.8	-1.6	-2.1	-2.1
Alcohol intake frequency.	0.5	1.2	3.7	-0.1	0.3	1.7	1.9	-0.3	-0.5
Comparative height size at age 10	0.1	0.3	0.6	-0.7	0.7	-0.4	-0.2	-0.8	-0.0
Number of full sisters	0.1	0.1	0.3	-0.3	-0.0	-0.6	-0.5	0.1	-0.1
Suffer from ‘nerves’	1.0	1.5	4.1	-1.2	-0.9	2.0	1.3	-0.9	0.7
Overall health rating	0.6	1.2	4.4	0.6	-1.3	-0.1	-0.3	0.9	2.1
Chest pain or discomfort	0.4	0.6	1.4	-0.3	-1.2	1.0	-0.1	0.1	0.9
Had major operations	0.7	0.8	2.1	0.5	0.0	-1.5	1.1	0.7	0.7
Age at last live birth	0.4	0.5	2.2	0.7	-1.5	0.3	0.5	0.2	0.2
Family relationship satisfaction	0.5	0.6	1.6	0.2	1.2	0.4	1.2	-0.1	-0.8
Leg pain on walking	1.2	1.5	4.8	1.6	0.0	-0.8	-0.8	2.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.6	-0.6	-1.3	-0.2	-0.2	0.2	-0.3
Commuting to job workplace: Car/motor vehicle	0.9	1.0	4.9	0.3	0.9	2.2	-0.4	0.6	0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.8	-0.3	-0.8	-1.4	-1.0	-0.6	-0.6
Medication: Aspirin	0.2	0.3	0.7	0.6	0.3	-0.2	-0.2	0.8	0.9
Supplements: Vitamin C	0.8	0.9	1.5	0.3	-1.2	-1.2	-1.0	1.1	-0.6
Knee pain experienced in last month	1.4	2.2	4.8	1.7	1.7	0.5	-0.8	2.2	1.2
Hypertension (Self-reported)	0.3	0.8	2.6	-0.6	1.6	-0.5	-0.8	-0.0	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.9	-0.5	0.9	0.2	0.7	0.0	-1.4
Illnesses of father: Heart disease	0.2	0.3	1.0	-0.3	0.1	-0.7	-1.0	-0.1	0.7
Illnesses of siblings: Diabetes	0.8	0.9	3.0	-0.2	-0.2	-0.7	-1.7	-0.0	1.4
Smoking status: Previous	1.4	2.1	4.9	-1.7	-2.2	-1.2	-1.3	-1.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	7.0	1.0	0.1	2.6	0.9	0.5	0.4
Whole body fat-free mass	0.1	0.7	2.7	-0.1	1.6	0.9	-0.3	-0.6	-0.0
Leg fat-free mass (right)	0.0	0.3	1.3	0.1	1.1	0.4	0.0	-0.3	0.0
Arm fat percentage (left)	1.0	4.0	7.0	2.6	0.3	-1.1	-1.6	2.6	2.6
Average weekly red wine intake	0.6	0.8	1.8	0.7	1.1	-0.9	-1.3	0.5	0.5
Handedness (chirality/laterality): Left-handed	1.1	1.4	4.8	0.0	-2.2	1.2	-0.2	-0.1	1.3
Mood swings	0.8	1.4	4.3	1.6	0.2	-0.6	-0.8	2.1	0.8
Loneliness, isolation	0.7	0.9	2.5	1.0	-0.8	-0.3	0.1	1.1	1.6
Long-standing illness, disability or infirmity	0.8	1.3	3.3	0.4	-0.3	-1.8	-0.3	0.8	1.8
Ever had bowel cancer screening	0.3	0.4	1.5	-0.4	0.6	-0.3	-1.2	-0.0	-0.5
Diabetes diagnosed by doctor	0.8	1.4	2.7	1.6	0.3	0.3	-1.3	1.4	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.8	-0.2	-0.3	-0.4	-1.3	0.4	-1.0
Friendships satisfaction	0.2	0.3	0.9	0.7	0.4	0.2	1.0	0.3	-0.0
Qualifications: nursing, teaching	1.3	2.0	5.8	-1.5	-0.3	-0.9	-2.4	-1.7	0.5
Commuting to job workplace: Walk	1.4	1.5	4.3	-1.1	-0.5	-0.0	2.1	-0.7	-1.6
Eye problems/disorders: Cataract	0.9	1.1	2.2	-1.0	-1.3	-1.5	0.0	-1.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.5	-0.6	-0.8	-1.3	0.9	-0.2	-1.6
Medication for cholesterol	0.1	0.2	0.8	-0.6	-0.1	-0.1	-0.1	-0.9	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.5	0.4	-0.3	0.3	-1.6	0.6	1.4
Back pain experienced in last month	1.8	2.6	7.7	-0.2	2.8	2.0	1.8	0.0	-0.7
Mineral and other dietary supplements	0.5	0.7	1.1	0.9	0.7	0.8	1.0	1.0	-0.2
Breast cancer (self-reported)	0.6	0.7	1.6	-0.7	1.3	0.5	0.8	-0.2	-1.1
Asthma (self-reported)	0.1	0.3	0.8	-0.6	-0.3	-0.9	0.2	-0.4	0.3
Osteoporosis (self-reported)	1.2	1.5	4.0	-1.1	-1.2	-2.0	-0.9	-1.1	0.4
Osteoarthritis (self-reported)	0.5	0.6	1.1	0.9	0.1	-1.0	1.1	0.9	-0.2
Medication: Aspirin	0.6	0.8	2.1	0.9	0.1	-0.8	-0.5	0.9	1.4
Medication: Gliclazide	2.4	2.7	6.9	2.6	-1.3	-0.1	-0.4	2.5	1.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	1.1	-1.0	-0.0	-0.4	0.3	0.8
Smoking status: Current	0.6	1.0	3.0	0.5	0.2	1.1	1.7	0.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	5.7	2.4	0.6	0.4	-1.2	0.9	2.0
Whole body water mass	0.1	0.8	3.2	-0.2	1.8	1.0	-0.3	-0.7	-0.0
Leg predicted mass (right)	0.0	0.2	1.2	0.0	1.1	0.4	0.0	-0.4	-0.0
Arm fat mass (left)	0.7	2.8	4.6	2.1	1.0	-0.7	-1.7	2.0	1.9
Number of self-reported non-cancer illnesses	0.7	1.2	3.7	-1.5	0.2	-1.9	-0.8	-0.6	-0.3
Average weekly champagne plus white wine intake	0.4	0.5	1.8	0.3	-1.3	-0.7	-0.8	-0.1	0.2
Miserableness	0.7	1.2	2.4	0.9	0.8	1.5	1.0	1.5	0.2
Guilty feelings	0.4	0.6	2.8	-0.1	-0.5	0.2	-0.2	-0.5	1.7
Wears glasses or contact lenses	1.5	1.7	3.8	2.0	-0.8	-0.7	-0.4	1.6	1.7
Ever taken oral contraceptive pill	0.8	0.9	2.3	-0.2	-0.5	0.6	1.5	-0.5	1.5
Hearing aid user	0.1	0.2	0.6	-0.0	0.4	-0.4	-0.2	0.3	-0.8
Mother’s age at death	0.2	0.2	0.3	-0.5	0.5	0.6	0.4	-0.5	-0.3
Financial situation satisfaction	0.3	0.4	1.5	0.0	-0.2	1.2	0.9	0.3	-0.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.7	-0.8	-0.6	0.7	-0.8	-0.7	0.8
Commuting to job workplace: Public transport	1.6	1.9	6.2	-1.3	-1.0	-2.5	-0.4	-1.6	-0.1
Eye problems/disorders: Glaucoma	0.8	1.0	3.0	-1.3	-1.7	0.1	-0.5	-1.0	-0.0
Medication: Blood pressure	0.4	0.8	3.1	-0.2	1.8	0.2	0.4	0.4	-1.0
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.9	1.1	0.9	-0.6	-0.2	1.4	0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.7	-0.2	0.5	0.1	-0.7	-0.2	0.9
High cholesterol (Self-reported)	0.2	0.4	1.3	0.2	-0.3	-0.8	-1.2	0.3	-0.0
Medication: Bendroflumethiazide	0.4	0.7	1.3	0.3	0.7	-1.0	1.0	0.3	-1.1
Medication: Paracetamol	1.0	1.6	3.9	-2.0	-0.4	-1.0	-0.9	-1.9	0.3
Medication: Lisinopril	0.5	0.7	2.4	-0.9	1.5	0.2	0.6	-0.8	-0.1
Medication: Atorvastatin	1.3	1.6	3.5	-1.8	-1.2	-0.3	1.2	-1.9	-0.1
Illnesses of father: High blood pressure	0.7	0.8	2.5	0.3	1.3	0.3	0.4	0.6	-1.6
Alcohol drinker status: Never	0.6	0.7	1.6	-0.6	0.7	-0.7	0.9	-0.7	-1.2
Ever smoked	0.8	1.4	2.3	-1.5	-0.4	0.0	1.5	-1.1	-1.5
Basal metabolic rate	0.1	0.6	2.6	0.3	1.6	0.8	-0.6	-0.2	0.4
Leg fat percentage (left)	1.5	5.4	9.7	2.8	0.8	-1.0	-2.0	3.0	3.1
Arm fat-free mass (left)	0.2	1.1	4.6	0.1	2.1	1.4	-0.6	-0.3	0.0
Number of operations (self-reported)	0.6	0.9	3.9	0.1	-0.1	-2.0	1.1	0.2	0.3
Average weekly beer plus cider intake	0.6	0.8	1.6	-1.1	-0.5	-0.2	0.9	-1.0	-1.2
Irritability	0.4	0.7	1.2	0.8	-0.7	0.3	-1.0	1.1	1.0
Risk taking	0.2	0.3	0.8	0.6	-0.0	0.3	0.6	0.2	0.9
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.9	-0.4	0.2	-0.3	-1.4	-0.8	0.1
Fractured/broken bones in last 5 years	1.2	1.6	5.4	-0.2	-1.7	-2.3	0.8	0.5	-0.6
Age started oral contraceptive pill	0.4	0.5	1.1	-0.8	0.1	-0.9	-0.0	-1.1	0.6
Diastolic blood pressure, automated reading	0.6	1.9	8.8	-0.4	1.5	-0.2	0.1	0.1	-3.0
Ever depressed for a whole week	2.8	3.5	7.5	2.4	1.4	1.4	1.7	2.7	-1.1
Unable to work because of sickness or disability	0.5	0.6	2.1	0.9	-0.3	0.6	0.4	1.4	-0.3
Commuting to job workplace: Cycle	0.0	0.0	0.2	-0.1	0.0	0.1	-0.2	-0.4	0.1
Myopia	0.3	0.5	1.3	0.5	0.5	0.2	1.0	0.3	1.2
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.0	0.6	-1.4	0.6	1.4	0.0	0.3
Cholesterol lowering medication	0.2	0.3	1.0	0.1	-1.0	0.2	0.4	0.2	0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.6	-1.6	-0.2	-0.7	-1.3	-1.1	-0.6
Pain experienced in last month	0.5	0.9	3.3	0.7	-1.0	-1.8	-0.6	0.3	-0.2
Supplements: Calcium	1.7	1.8	5.1	-1.2	-2.3	-1.9	-0.3	-0.9	0.3
Basal cell carcinoma (self-reported)	1.6	1.9	4.2	-2.0	1.4	-1.1	0.7	-1.9	-0.5
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.2	-0.8	-1.5	-0.3	-0.6	-0.8	1.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.8	0.8	1.5	1.9	0.3	0.7	-0.1
Heart disease (siblings)	0.7	0.8	3.5	0.7	-0.4	-0.7	-0.4	0.6	1.9
Alcohol drinker status: Previous	0.9	1.0	3.6	0.6	-0.0	-0.3	1.9	0.6	-1.3
Pack years of smoking	0.9	1.3	3.0	1.7	0.3	0.4	1.3	1.5	0.5
Impedance of whole body	0.3	1.3	4.3	0.9	-2.1	-0.9	0.5	0.9	0.8
Leg fat mass (left)	1.2	4.8	8.9	2.7	1.1	-0.7	-2.2	2.5	3.0
Arm predicted mass (left)	0.1	0.7	2.6	0.2	1.6	1.0	-0.8	-0.2	0.1